Disc type mouse local irradiation device
By designing a disc-type mouse local irradiation device, the problems of irradiation dose error and inconsistent anesthesia in mouse local irradiation experiments were solved. This approach achieves simple operation, precise irradiation dose, and consistent anesthesia effect, thereby improving the accuracy of experimental data.
Patent Information
- Application Number
- CN202511967221.0
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-12-24
- Publication Date
- 2026-03-17
AI Technical Summary
Existing local irradiation experiments on mice are cumbersome to perform. The different distances of multiple mice from the radiation source lead to large errors in irradiation dosage, inconsistent anesthetic effects, and affect the accuracy of experimental data.
A disc-shaped local irradiation device for mice is designed, comprising a base, a circular shield, a support sleeve, and a top cover. The irradiation window is adjusted by a window adjustment plate and positioning bolts to ensure that the mice are at the same distance from the radiation source. An anesthetic gas inlet and outlet are provided to achieve a continuous anesthetic effect.
Simplify operations, reduce irradiation dose errors, improve data accuracy, ensure consistent anesthesia in multiple mice, and enhance the reliability of experimental results.
Smart Images
Figure CN121668580A_ABST
Abstract
Description
Technical Field
[0001] This invention relates to the field of targeted irradiation experimental devices for mice, and more particularly to a disc-type local irradiation device for mice. Background Technology
[0002] In fields such as tumor radiobiology research, radiotherapy protocol translation, and exploration of radiation damage repair mechanisms, mice are commonly used laboratory animals, and their localized, precise irradiation experiments are a crucial link connecting basic research and clinical applications. By locally irradiating specific target areas (such as tumor tissue or organs) in mice, clinical radiotherapy scenarios can be simulated, and the correlation between irradiation dose and biological effects can be analyzed, providing reliable experimental data for optimizing radiotherapy protocols and developing radiation protection drugs.
[0003] In laboratory local irradiation experiments on live mice, the mice must first be anesthetized. Their limbs are then secured with tape or restraints to prevent movement during irradiation. The mice are then placed inside the irradiation equipment, and non-target areas are shielded with lead sheets (3-8 mm thick). The equipment is then activated, and the mice are irradiated for the set time and dose. This existing method of local irradiation of mice is cumbersome. When using the same equipment to irradiate multiple mice simultaneously, the distance between the mice and the radiation source varies, leading to significant errors in irradiation dosage and data. Furthermore, irradiating multiple mice simultaneously requires each mouse to be individually connected to anesthesia masks. These masks are miniaturized anesthesia delivery devices specifically designed for mouse head sizes. Due to individual differences among mice and operational errors in connection, varying degrees of anesthesia can occur. Mice with insufficient anesthesia may struggle or shift position, affecting the accuracy of the experimental data. Summary of the Invention
[0004] The purpose of this invention is to overcome the shortcomings of the prior art and provide a disc-type local irradiation device for mice that is simple and convenient to operate, ensures that multiple mice are at the same distance from the radiation source, has a small error in the irradiation dose, and has a good anesthesia effect.
[0005] The technical solution adopted by this invention to overcome the shortcomings of the prior art is as follows:
[0006] A disc-type local irradiation device for mice includes a base. The base is characterized by a circular shield plate fixedly mounted on it via a support frame. The circular shield plate has at least three vertically penetrating irradiation slots arranged in a circular array. A support sleeve is provided on the base surrounding the circular shield plate. A circular upper cover plate is provided on the support sleeve above the circular shield plate. An adjustment groove is provided on the upper side of the upper cover plate opposite to the irradiation slots. A window adjustment plate is provided within the adjustment groove, and a positioning bolt is provided on the window adjustment plate. The support sleeve has an anesthetic gas inlet and an anesthetic gas outlet.
[0007] The circular shielding plate described in this invention has five irradiation slots. The base has an upwardly protruding positioning pin, and the lower side of the support sleeve has a positioning hole that mates with the positioning pin. The positioning pin is inserted into the positioning hole. The support sleeve is fixedly connected to the upper cover plate or is integrally formed. After the support sleeve is fitted onto the outside of the circular shielding plate and the positioning pin is inserted into the positioning hole, the window adjustment plate is located above the irradiation slot and can completely block it.
[0008] In this invention, the length of the irradiation slot is less than the length of the window adjustment plate, the length of the adjustment groove is not less than twice the length of the shielding plate, and the width of the window adjustment plate is greater than the width of the irradiation slot. The window adjustment plate has a long, vertically extending positioning groove. The positioning bolt includes a screw and a locking head. The screw can slide freely within the positioning groove. The upper cover plate below the positioning groove has a positioning threaded hole that mates with the screw of the positioning bolt. When the screw of the positioning bolt is tightened in conjunction with the positioning threaded hole, the locking head can lock and fix the window adjustment plate within the adjustment groove. The positioning groove increases the sliding range of the window adjustment plate within the adjustment groove.
[0009] The invention is further improved by providing at least two positioning threaded holes on the upper cover plate below the positioning slide groove along the length of the slide groove. This further expands the sliding range of the window adjustment plate within the adjustment slide groove.
[0010] The circular shield and window adjustment plate described in this invention both include a lead plate layer and an outer cladding layer, with the outer cladding layer enclosing the lead plate layer. This avoids direct contact with the human body during use, preventing injury.
[0011] In use, the supporting sleeve, top cover, and window adjustment plate are lifted upwards or removed directly from the circular shielding plate. Anesthetized mice are placed between the circular shielding plate and the base under the irradiation window. The supporting sleeve, top cover, and window adjustment plate are then placed on top of the circular shielding plate from top to bottom, covering the outside of the shielding plate. A positioning pin is inserted into the positioning hole on the lower side of the supporting sleeve. The window adjustment plate is slid to offset the irradiation slot vertically, forming an irradiation window. The radiation from top to bottom can pass through the irradiation window and directly irradiate the mouse's body below. During use, the mouse is usually placed horizontally under the irradiation window, with the area to be irradiated positioned directly below the window. The window adjustment plate is mainly used to adjust the size of the irradiation window according to the width of the irradiated area. After placing the mice in the irradiation window and adjusting the position, the disc-shaped mouse local irradiation device is placed inside the irradiation equipment. The anesthetic gas inlet and outlet are connected to the anesthesia machine. The position of the circular shield inside the irradiation equipment is adjusted so that the radiation source of the irradiation equipment is aligned with the axis of the circular shield. Subsequent operations of the mouse irradiation experiment are then performed. This invention features a simple structure and convenient operation. When using the same irradiation equipment to simultaneously irradiate multiple mice, the distance error between the mice and the radiation source is small, the irradiation dose error is small, and the data is accurate. The anesthetic gas inlet and outlet settings allow for a continuous input of the required concentration of anesthetic gas, resulting in a high degree of consistency in the anesthesia level of the mice. Attached Figure Description
[0012] Figure 1 This is a three-dimensional structural diagram of the present invention.
[0013] Figure 2 This is a top view of the structure of the present invention.
[0014] Figure 3 yes Figure 2 A schematic diagram of the AA cross-sectional structure.
[0015] Figure 4 This is a three-dimensional structural diagram of the support sleeve and the upper cover plate in this invention.
[0016] Figure 5 yes Figure 4 A three-dimensional structural diagram from another perspective.
[0017] Figure 6 This is a three-dimensional structural diagram of the base, support frame, and circular shield in this invention. Detailed Implementation
[0018] like Figures 1-6 The disc-shaped local irradiation device for mice shown has a disc-shaped base 7, on which a circular shield 11 is fixedly mounted via a support frame. Figure 3 , Figure 6As can be seen, the support frame consists of five support columns 12 arranged in a circular array between the base 7 and the circular shielding plate 11. The upper end of each support column 12 is fixedly connected to the circular shielding plate 11, and the lower end is fixedly connected to the base 7. The support structure is simple, occupies little space, and facilitates the placement of mice between the circular shielding plate 11 and the base 7. The circular shielding plate 11 has five elongated rectangular irradiation slots 10 arranged in a circular array, running radially and vertically. The irradiation slots 10 are located in the middle of two adjacent support columns 12. A support sleeve 6 is provided on the base 7 on the outer periphery of the circular shield 11. A circular upper cover plate 1 is provided on the support sleeve 6 above the circular shield 11. An adjustment groove 5 is provided on the upper side of the upper cover plate 1 opposite to the irradiation slot 10, which is radially arranged along the circular shield. A window adjustment plate 2 that can slide radially along the circular shield is provided in the adjustment groove 5. A positioning bolt 3 is provided on the window adjustment plate 2. An anesthetic gas inlet 8 and an anesthetic gas outlet 14 are provided on the support sleeve 6. Two upwardly protruding positioning pins 15 are provided on the base 7 opposite to the support sleeve. A positioning insertion hole 13 that cooperates with the positioning pins 15 is provided on the lower side of the support sleeve 6. The positioning pins 15 can slide up and down relative to each other and are inserted into the positioning insertion hole 13. The support sleeve 6 is fixedly connected to the upper cover plate 1 or is made into one piece. After the support sleeve 6 is sleeved on the outside of the circular shield 11 and the positioning pins 15 are inserted into the positioning insertion hole 13, the window adjustment plate 2 is located on the upper side of the irradiation slot 10 and can completely block it. The length of the irradiation slot 10 (its radial dimension in the circular shield) is less than the length of the window adjustment plate 2. The length of the adjustment groove 5 (its radial dimension in the circular shield) is not less than twice the length of the window adjustment plate 2. The width of the window adjustment plate 2 (its circumferential dimension in the circular shield) is greater than the width of the irradiation slot. A long, vertically extending positioning groove 4, not opposite to the irradiation slot 10, is provided on the window adjustment plate 2, running radially along the circular shield. The positioning bolt 3 includes a screw and a locking head. The screw can slide freely radially within the positioning groove 4. The upper cover plate 1 below the positioning groove 4 has a positioning threaded hole 9 that mates with the screw of the positioning bolt 3. When the screw of the positioning bolt 3 is tightened in conjunction with the positioning threaded hole 9, the locking head locks the window adjustment plate 2 securely within the adjustment groove. The positioning groove 4 increases the sliding range of the window adjustment plate within the adjustment groove, expanding the size range of the irradiation window and broadening its applicability.
[0019] The invention is further improved by providing three positioning threaded holes 9 on the upper cover plate 1 below the positioning groove 4 along the length of the positioning groove (the radial dimension of the circular shield plate), further expanding the sliding range of the window adjustment plate within the adjustment groove. Both the circular shield plate 11 and the window adjustment plate 2 include a lead plate layer and an outer cladding layer, with the outer cladding layer enclosing the lead plate layer. This avoids direct contact with the human body during use, preventing injury. To reduce the impact of scattering on the experiment, the base, support sleeve, and upper cover plate in this invention can also be manufactured using radiation-shielding materials including a lead plate layer and an outer cladding layer.
[0020] In use, the supporting sleeve, top cover, and window adjustment plate are lifted upwards or removed directly from the circular shield. A lead pad to prevent scattering is placed on the upper side of the base. The anesthetized mouse is placed between the circular shield and the base onto the lead pad under the irradiation window. The supporting sleeve, top cover, and window adjustment plate are then placed on top of the circular shield from top to bottom on the outside of the circular shield. The positioning pin is inserted into the positioning hole on the lower side of the supporting sleeve. The window adjustment plate is slid to offset the window adjustment plate from the irradiation slot in the vertical direction, forming an irradiation window. The radiation from top to bottom can pass through the irradiation window and directly irradiate the mouse's body below. During use, the mouse is usually placed horizontally under the irradiation window (i.e., the mouse's front-to-back direction is perpendicular to the radial direction of the circular shield). The part to be irradiated (head, chest, abdomen, or hind legs) is placed directly below the irradiation window. At this time, the window adjustment plate is mainly used to adjust the size of the irradiation window according to the width of the irradiated part. After placing the mice in the irradiation window and adjusting the position, the disc-shaped mouse local irradiation device is placed inside the irradiation equipment. The anesthetic gas inlet and outlet are connected to the anesthesia machine. The position of the circular shield inside the irradiation equipment is adjusted so that the radiation source of the irradiation equipment is aligned with the axis of the circular shield. Subsequent operations of the mouse irradiation experiment are then performed. This invention features a simple structure and convenient operation. When using the same irradiation equipment to simultaneously irradiate multiple mice, the distance error between the mice and the radiation source is small, the irradiation dose error is small, and the data is accurate. The anesthetic gas inlet and outlet settings allow for a continuous input of the required concentration of anesthetic gas, resulting in a high degree of consistency in the anesthesia level of the mice.
Claims
1. A circular disc type mouse local irradiation device provided with a base, characterized in that, The base is fixedly installed with a circular shielding plate through a support frame, the circular shielding plate is provided with at least three irradiation slots penetrating from top to bottom in a circular array, a support sleeve is arranged on the base at the outer periphery of the circular shielding plate, a circular upper cover plate is arranged on the support sleeve above the circular shielding plate, an adjusting sliding groove is arranged on the upper cover plate at the position opposite to the irradiation slots, a window adjusting plate is arranged in the adjusting sliding groove, a positioning bolt is arranged on the window adjusting plate, and a narcotic gas inlet and a narcotic gas outlet are arranged on the support sleeve.
2. The disc mouse local irradiation device according to claim 1, wherein The circular shielding plate is provided with five irradiation slots, the base is provided with an upwardly protruding positioning pin, the lower side of the support sleeve is provided with a positioning insertion hole matched with the positioning pin, and the positioning pin is inserted into the positioning insertion hole.
3. The disc mouse local irradiation device according to claim 1, wherein The length of the irradiation slot is less than the length of the window adjusting plate, the length of the adjusting sliding groove is not less than twice the length of the shielding plate, the width of the window adjusting plate is greater than the width of the irradiation slot, the window adjusting plate is provided with a long strip-shaped positioning sliding groove penetrating from top to bottom, the positioning bolt comprises a screw rod and a locking head, the screw rod can freely slide in the positioning sliding groove, and the upper cover plate below the positioning sliding groove is provided with a positioning thread hole matched with the screw rod of the positioning bolt.
4. The disc mouse local irradiation device according to claim 3, wherein The upper cover plate below the positioning sliding groove is provided with at least two positioning thread holes along the length direction of the positioning sliding groove.
5. The disc mouse local irradiation device according to claim 3, wherein The circular shielding plate and the window adjusting plate both comprise a lead plate layer and an outer wrapping layer, and the outer wrapping layer wraps the lead plate layer.