Use of PTN in the preparation of a product for treating cognitive impairment resulting from severe infection
The siRNA therapy strategy targeting the PTN signaling pathway addresses long-term cognitive impairment caused by severe infection, achieving precise intervention in chronic inflammation of the central nervous system, improving cognitive function, and providing broad therapeutic applicability.
CN121695284BActive Publication Date: 2026-06-23INSTITUTE OF BASIC MEDICAL SCIENCES CHINESE ACADEMY OF MEDICAL SCIENCES
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- INSTITUTE OF BASIC MEDICAL SCIENCES CHINESE ACADEMY OF MEDICAL SCIENCES
- Filing Date
- 2026-02-24
- Publication Date
- 2026-06-23
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Figure CN121695284B_ABST
Abstract
The application discloses application of PTN in preparation of products for treating cognitive impairment caused by severe infection. The inhibitor of PTN provided by the application can inhibit chronic neuroinflammation, thereby preventing and inhibiting formation and development of late cognitive impairment caused by severe infection, and meanwhile, inhibition of expression or function of PTN can effectively block damage of infiltrating macrophages to microglia cells, thereby providing a new direction for treatment of related diseases.
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