Ventilation method and ventilation equipment

Abstract

The embodiment of the invention discloses a ventilation method and ventilation equipment. The accuracy and safety of ventilation control can be improved. Wherein the ventilation equipment comprises a nitric oxide output module, or the ventilation equipment is in communication connection with the nitric oxide output module; the ventilation equipment is used for outputting first gas containing air and oxygen to the patient end; the nitric oxide output module is used for outputting second gas containing nitric oxide to the patient end; the gas outlet of the second gas is connected between the conveyed first gas and the patient end; the ventilation method comprises the following steps: determining a target gas flow rate corresponding to a patient end based on a target ventilation parameter corresponding to ventilation equipment; acquiring a second gas flow rate corresponding to the second gas; determining a target first gas flow rate corresponding to the first gas based on the second gas flow rate and the target gas flow rate; and outputting the first gas at the target first gas flow rate, so that the gas provided to the patient end meets the requirements of the target ventilation parameters.

Description

Technical Field

[0001] This invention relates to the field of medical device technology. In particular, it relates to a ventilation method and ventilation device. Background Technology

[0002] Currently, when ventilators and other ventilation equipment are used in conjunction with nitric oxide (NO) therapy devices, the NO therapy device injects NO gas into the patient's end. Since the ventilator and other ventilation equipment can only control the parameters of their own output gas, the injected NO gas will cause changes in the gas parameters at the patient's end, making it impossible to meet the expected ventilation parameters on the ventilator. This will result in the inability to achieve the desired therapeutic effect, may also trigger ventilator alarms, and may even pose a risk of harm to the patient. Summary of the Invention

[0003] The present invention aims to provide a ventilation method and ventilation device that can improve the accuracy and safety of ventilation control.

[0004] The technical solution of this invention is implemented as follows:

[0005] This invention provides a ventilation method applied to a ventilation device. The ventilation device includes a nitric oxide output module, or the ventilation device is communicatively connected to the nitric oxide output module. The ventilation device further includes a breathing circuit connected to a patient, the ventilation device being used to output a first gas containing air and oxygen to the patient through the breathing circuit; the nitric oxide output module is used to output a second gas containing nitric oxide to the patient. The method includes:

[0006] Based on the target ventilation parameters corresponding to the ventilation equipment, determine the target gas flow rate at the patient end;

[0007] Obtain the flow rate of the second gas corresponding to the second gas;

[0008] Based on the second gas flow rate and the target gas flow rate, determine the target first gas flow rate corresponding to the first gas;

[0009] The first gas is output at the target first gas flow rate so that the gas supplied to the patient meets the requirements of the target ventilation parameters.

[0010] This invention provides a ventilation method applied to a ventilation device. The ventilation device includes a nitric oxide output module, or the ventilation device is communicatively connected to the nitric oxide output module. The ventilation device further includes a breathing circuit connected to a patient, wherein the ventilation device is used to input air and oxygen into the breathing circuit respectively, and the air and oxygen are mixed in the breathing circuit to form a first gas which is output to the patient. The nitric oxide output module is used to output a second gas containing nitric oxide to the patient. The method includes:

[0011] Based on the target gas flow rate and target oxygen concentration corresponding to the ventilation equipment, determine the target carrier gas flow rate and the target oxygen flow rate corresponding to the oxygen.

[0012] Obtain the flow rate of the second gas corresponding to the second gas;

[0013] Determine the target air velocity corresponding to the air based on the target carrier gas velocity and the second gas velocity;

[0014] Air is supplied to the breathing circuit at the target airflow rate, and oxygen is supplied to the breathing circuit at the target oxygenflow rate, so that the oxygen concentration at the patient end meets the target oxygen concentration requirement.

[0015] This invention provides a ventilation method applied to a nitric oxide output module, wherein the nitric oxide output module is communicatively connected to a ventilation device, or the ventilation device includes the nitric oxide output module. The ventilation device is used to output a first gas containing air and oxygen to the patient end via a breathing circuit connected to the patient end at a target first gas flow rate; the nitric oxide output module is used to output a second gas containing nitric oxide to the patient end at a target second gas flow rate; the nitric oxide output module is further used to detect the nitric oxide concentration of the gas at the patient end to determine the nitric oxide concentration at the patient end; the method includes:

[0016] Based on the nitric oxide concentration at the patient end and the target nitric oxide concentration, the flow rate of the target second gas and / or the nitric oxide concentration in the second gas are adjusted to ensure that the nitric oxide concentration at the patient end meets the requirement of the target nitric oxide concentration.

[0017] And / or,

[0018] The nitric oxide concentration at the patient end is transmitted to the ventilation device, so that the ventilation device adjusts the target first gas flow rate based on the nitric oxide concentration at the patient end and the target nitric oxide concentration, so that the nitric oxide concentration at the patient end meets the requirement of the target nitric oxide concentration.

[0019] This invention provides a ventilation method applied to a ventilation device, the ventilation device comprising: a nitric oxide output module, or the ventilation device being communicatively connected to the nitric oxide output module; the ventilation device being used to output a first gas containing air and oxygen to the patient end via a breathing circuit connected to the patient end at a target first gas flow rate; the nitric oxide output module being used to output a second gas containing nitric oxide to the patient end; the nitric oxide output module being further used to detect the nitric oxide concentration of the gas at the patient end, and determine the nitric oxide concentration at the patient end; the method comprising:

[0020] Obtain the nitric oxide concentration at the patient end;

[0021] Based on the nitric oxide concentration at the patient end and the target nitric oxide concentration, the target first gas flow rate is adjusted so that the nitric oxide concentration at the patient end meets the requirement of the target nitric oxide concentration.

[0022] This invention provides a ventilation device, which includes: a nitric oxide output module and a breathing circuit connected to a patient; the ventilation device is used to output a first gas containing air and oxygen to the patient through the breathing circuit; the nitric oxide output module is used to output a second gas containing nitric oxide to the patient; a gas flow sensor is provided at the gas outlet of the second gas; wherein, the gas flow sensor provided at the gas outlet of the second gas is used to obtain the second gas flow rate corresponding to the second gas.

[0023] The ventilation device is also used to determine the target gas flow rate corresponding to the patient end based on the target ventilation parameters set by the user; to determine the target first gas flow rate corresponding to the first gas based on the second gas flow rate and the target gas flow rate; and to output the first gas at the target first gas flow rate so that the gas provided to the patient end meets the requirements of the target ventilation parameters.

[0024] This invention provides a ventilation device, which is communicatively connected to a nitric oxide output module. The ventilation device includes: a breathing circuit connected to a patient; the ventilation device is used to output a first gas containing air and oxygen to the patient through the breathing circuit; the nitric oxide output module is used to output a second gas containing nitric oxide to the patient; a gas flow sensor is provided at the gas outlet of the second gas; wherein, the nitric oxide output module is used to obtain the second gas flow rate corresponding to the second gas through the gas flow sensor provided at the gas outlet of the second gas, and transmit it to the ventilation device.

[0025] The ventilation device is also used to determine the target gas flow rate corresponding to the patient end based on the target ventilation parameters set by the user; to determine the target first gas flow rate corresponding to the first gas based on the second gas flow rate and the target gas flow rate; and to output the first gas at the target first gas flow rate so that the gas provided to the patient end meets the requirements of the target ventilation parameters.

[0026] This invention provides a ventilation device, which includes: a nitric oxide output module and a breathing circuit connected to a patient end. The ventilation device is used to input air and oxygen into the breathing circuit respectively, and the air and oxygen are mixed in the breathing circuit to form a first gas which is output to the patient end. The nitric oxide output module is used to output a second gas containing nitric oxide to the patient end. A gas flow sensor is provided at the gas outlet of the second gas to obtain the flow rate of the second gas.

[0027] The ventilation equipment is also used to: determine the target carrier gas flow rate and the target oxygen flow rate corresponding to oxygen based on the target gas flow rate and target oxygen concentration set by the user; determine the target air flow rate corresponding to air based on the target carrier gas flow rate and the second gas flow rate; input air into the breathing circuit at the target air flow rate and input oxygen into the breathing circuit at the target oxygen flow rate, so that the oxygen concentration at the patient end meets the requirements of the target oxygen concentration.

[0028] This invention provides a ventilation device that is communicatively connected to a nitric oxide output module. The ventilation device includes a breathing circuit connected to a patient. The ventilation device is used to input air and oxygen into the breathing circuit, where the air and oxygen are mixed to form a first gas, which is then output to the patient. The nitric oxide output module is used to output a second gas containing nitric oxide to the patient. The nitric oxide output module is used to obtain the second gas flow rate corresponding to the second gas through a gas flow sensor installed at the gas outlet of the second gas, and transmit this information to the ventilation device.

[0029] The ventilation equipment is also used to: determine the target carrier gas flow rate and the target oxygen flow rate corresponding to oxygen based on the target gas flow rate and target oxygen concentration set by the user; determine the target air flow rate corresponding to air based on the target carrier gas flow rate and the second gas flow rate; input air into the breathing circuit at the target air flow rate and input oxygen into the breathing circuit at the target oxygen flow rate, so that the oxygen concentration at the patient end meets the requirements of the target oxygen concentration.

[0030] This invention provides a nitric oxide output module, which is communicatively connected to a ventilation device. The ventilation device outputs a first gas containing air and oxygen to the patient via a breathing circuit connected to the patient at a target first gas flow rate. The nitric oxide output module outputs a second gas containing nitric oxide to the patient at a target second gas flow rate. The nitric oxide output module is also used to detect the nitric oxide concentration of the gas at the patient and determine the nitric oxide concentration at the patient. Furthermore, the nitric oxide output module is used to:

[0031] Based on the nitric oxide concentration at the patient end and the target nitric oxide concentration, the target second gas flow rate and / or the nitric oxide concentration in the second gas are adjusted to ensure that the nitric oxide concentration at the patient end meets the target nitric oxide concentration requirement; and / or, the nitric oxide concentration at the patient end is transmitted to the ventilation device so that the ventilation device adjusts the target first gas flow rate based on the nitric oxide concentration at the patient end and the target nitric oxide concentration to ensure that the nitric oxide concentration at the patient end meets the target nitric oxide concentration requirement.

[0032] This invention provides a ventilation device, comprising: a nitric oxide output module, wherein the ventilation device is used to output a first gas containing air and oxygen to the patient end via a breathing circuit connected to the patient end at a target first gas flow rate; the nitric oxide output module is used to output a second gas containing nitric oxide to the patient end; the nitric oxide output module is further used to detect the nitric oxide concentration of the gas at the patient end and determine the nitric oxide concentration at the patient end; the ventilation device is further used to:

[0033] Obtain the nitric oxide concentration at the patient end; based on the nitric oxide concentration at the patient end and the target nitric oxide concentration, adjust the target first gas flow rate so that the nitric oxide concentration at the patient end meets the requirement of the target nitric oxide concentration.

[0034] This invention provides a ventilation method and a ventilation device. The ventilation device, through a breathing circuit connected to a patient, outputs a first gas containing air and oxygen to the patient. A nitric oxide output module outputs a second gas containing nitric oxide to the patient. Based on the target ventilation parameters corresponding to the ventilation device, the desired target gas flow rate input to the patient can be determined. The second gas flow rate is obtained, and the target first gas flow rate is determined based on the second gas flow rate and the target gas flow rate. This achieves the goal of determining the target first gas flow rate for outputting the first gas by combining the target ventilation parameters set on the ventilation device and the effect of the second gas addition on the first gas flow rate. Thus, by outputting the first gas at the target first gas flow rate, the ventilation device ensures that the gas supplied to the patient meets the requirements of the target ventilation parameters, thereby reducing the impact of nitric oxide injection on the gas parameters of the mixed gas actually reaching the patient when the ventilation device is used in conjunction with the nitric oxide output module. Therefore, the accuracy and safety of ventilation control are improved. Attached Figure Description

[0035] Figure 1-1 A schematic diagram of a ventilation device provided in an embodiment of the present invention;

[0036] Figure 1-2 A schematic diagram of the structure of a ventilation device provided in an embodiment of the present invention. Figure 2 ;

[0037] Figure 2 A schematic flowchart of a ventilation method provided in an embodiment of the present invention;

[0038] Figure 3 A schematic diagram of the structure of a ventilation device provided in an embodiment of the present invention. Figure 3 ;

[0039] Figure 4-1 A schematic diagram of the structure of a ventilation device provided in an embodiment of the present invention is shown in Figure 4.

[0040] Figure 4-2 This is a schematic diagram of the structure of a ventilation device provided in an embodiment of the present invention;

[0041] Figure 5-1 A schematic diagram illustrating the relationship between the first gas flow rate and the second gas flow rate provided in an embodiment of the present invention;

[0042] Figure 5-2 This is a schematic diagram illustrating the relationship between the first gas flow rate and the second gas flow rate in an embodiment of the present invention. Figure 2 ;

[0043] Figure 6 A schematic diagram of the structure of a ventilation device provided in an embodiment of the present invention. Figure 6 ;

[0044] Figure 7 A schematic flowchart of a ventilation method provided in an embodiment of the present invention. Figure 2 ;

[0045] Figure 8-1 A schematic diagram of the structure of a ventilation device provided in an embodiment of the present invention. Figure 7 ;

[0046] Figure 8-2 Eighth schematic diagram of a ventilation device provided in an embodiment of the present invention;

[0047] Figure 9-1 Schematic diagram nine of a ventilation device provided in an embodiment of the present invention;

[0048] Figure 9-2 This is a schematic diagram of the structure of a ventilation device provided in an embodiment of the present invention. Detailed Implementation

[0049] To make the objectives, technical solutions, and advantages of the present invention clearer, the present invention will be further described in detail below with reference to the accompanying drawings. The described embodiments should not be regarded as limitations on the present invention. All other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0050] In the following description, references are made to “some embodiments,” which describe a subset of all possible embodiments. However, it is understood that “some embodiments” may be the same subset or different subsets of all possible embodiments and may be combined with each other without conflict.

[0051] In the following description, the terms "first, second, third" are used merely to distinguish similar objects and do not represent a specific ordering of objects. It is understood that "first, second, third" may be interchanged in a specific order or sequence where permitted, so that the embodiments of the invention described herein can be implemented in an order other than that illustrated or described herein.

[0052] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains. The terminology used herein is for the purpose of describing embodiments of the invention only and is not intended to limit the invention.

[0053] Inhaled nitric oxide (NO) is widely used to treat respiratory diseases. The treatment typically involves injecting NO gas into the inspiratory branch of a ventilation system using a NO therapy device. The NO gas flow rate needs to be manually or automatically adjusted based on parameters such as the ventilation system's flow rate to control the NO concentration entering the patient's lungs. Usually, during treatment, a certain amount of airflow is also drawn from the inspiratory branch near the patient to monitor the actual concentrations of NO, carbon dioxide (NO2), and oxygen (O2).

[0054] Current NO therapy devices are mostly standalone products. These devices can only control and output adjustable high concentrations of NO and need to be used in conjunction with ventilation equipment such as ventilators to treat patients. However, because NO therapy devices and ventilators work independently, the following problems arise when they work together:

[0055] First, since NO gas is injected into the patient's inspiratory bronchus, and ventilation equipment such as ventilators can only control the gas parameters of the gas they output to the inspiratory bronchus, the NO gas injected into the inspiratory bronchus will cause changes in gas parameters such as oxygen concentration, tidal volume, and gas pressure in the inspiratory bronchus. This results in the oxygen concentration in the gas actually reaching the patient being inconsistent with the setting value on the ventilator, the tidal volume being inaccurate and unstable, the gas pressure being inaccurate and unstable, and it may even trigger the equipment alarm.

[0056] Second, the NO therapy device draws gas at a certain flow rate from the inspiratory branch to monitor the NO, NO2, and oxygen concentrations entering the inspiratory branch. The drawn gas may cause deviations in the calculation of parameters such as tidal volume in the inspiratory branch, potentially triggering false alarms from ventilation equipment such as ventilators.

[0057] In summary, current ventilation equipment, such as ventilators, when used in conjunction with NO treatment devices, suffers from inaccurate ventilation control, which may affect treatment outcomes, trigger ventilator alarms, or pose a risk of harm to patients, thereby reducing the accuracy and safety of ventilation control.

[0058] This invention provides a ventilation method and ventilation device that improve the accuracy and safety of ventilation control. The ventilation device provided in this invention includes, for example: Figure 1-1 The ventilation device 100-1 shown, or including, for example Figure 1-1 The ventilation device 100-2 is shown. Ventilation device 100-1 includes a nitric oxide output module 20; ventilation device 100-2 is communicatively connected to the nitric oxide output module 20. For either ventilation device 100-1 or ventilation device 100-2, the ventilation device further includes a breathing circuit 10-1 connected to the patient. The ventilation device is used to output a first gas containing air and oxygen to the patient through the breathing circuit 10-1. Figure 1-1 and Figure 1-2 As shown, air and oxygen enter the breathing circuit 10-1 respectively and mix to form a first gas. Exemplarily, the ventilation device can be connected to an air source via the air branch in the breathing circuit 10-1 and to an oxygen source via the oxygen branch in the breathing circuit 10-1 to obtain the air and oxygen in the first gas. The nitric oxide output module 20 is used to output a second gas containing nitric oxide to the patient. That is, the gas inhaled by the patient is a mixture of the first and second gases. The gas outlet of the second gas in the nitric oxide module 10 can be connected to any position on the inhalation tubing at the patient's end. Exemplarily, the gas outlet of the second gas can be connected to an air source, an oxygen source, or the gas outlet of the ventilation device, or, as... Figure 1-2 and Figure 1-2 As shown, the gas outlet of the second gas in the nitric oxide output module 20 is connected between the gas outlet 10-3 of the first gas and the patient end. The specific selection depends on the actual situation, and this embodiment of the invention does not impose limitations.

[0059] It should be noted that, Figure 1-2 and Figure 1-2 The shown example of the second gas outlet of the nitric oxide output module 20 being connected to the patient end via the breathing circuit 10-1 is merely one example of how the second gas outlet can be connected to the patient end. In some embodiments, the second gas outlet may also be connected between the first gas outlet 10-3 and the patient end via an accessory of the ventilation device or other tubing. The specific choice depends on the actual situation, and this embodiment of the invention does not impose any limitations.

[0060] In some embodiments, the nitric oxide output module may include a NO therapy device, and the ventilation equipment may include a ventilator, exemplarily a pneumatic ventilator or an electric ventilator. That is, the ventilator may integrate the NO therapy device, or the ventilator may be communicatively connected to the NO therapy device; thus, the ventilator can be used in conjunction with the NO therapy device, and through the ventilation method provided in this embodiment of the invention, accurate ventilation control can be achieved, meeting the requirements of the target ventilation parameters set by the operator, achieving the expected therapeutic effect, and improving the safety of the ventilation treatment process.

[0061] Based on the ventilation equipment provided in the embodiments of the present invention, the embodiments of the present invention also provide a ventilation method, such as... Figure 2 As shown, it includes:

[0062] S101. Based on the target ventilation parameters corresponding to the ventilation equipment, determine the target gas flow rate at the patient end.

[0063] In this embodiment of the invention, the ventilation parameters set by the operator on the ventilation device are obtained as target ventilation parameters. Target ventilation parameters represent the desired ventilation values ​​to be achieved by the gas supplied to the patient. In some embodiments, target ventilation parameters may include target pressure or target tidal volume. Based on the target ventilation parameters, the gas flow rate that the mixture of the first and second gases should achieve when delivered to the patient to reach the target ventilation parameters can be calculated, and this rate is taken as the target gas flow rate at the patient.

[0064] For example, based on the target pressure and the calculated relationship between gas flow rate and pressure, the required gas flow rate through the breathing circuit to reach the patient's end can be calculated to ensure that the gas pressure reaching the patient's end meets the target pressure, thereby determining the target gas flow rate at the patient's end. Based on the target tidal volume, the amount of gas reaching the patient's end per unit time to achieve the target tidal volume can be calculated, thereby determining the target gas flow rate at the patient's end.

[0065] S102. Obtain the second gas flow rate corresponding to the second gas.

[0066] In some embodiments, a gas flow sensor is provided at the gas outlet of the second gas. For example, such as... Figure 3 As shown, a gas flow sensor 10-4 is installed at the gas outlet of the nitric oxide output module 20, where the second gas is output. The flow rate of the second gas can be measured using the gas flow sensor at the gas outlet.

[0067] S103. Based on the second gas flow rate and the target gas flow rate, determine the target first gas flow rate corresponding to the first gas.

[0068] In this embodiment of the invention, the target gas flow rate represents the theoretical flow rate that the gas delivered to the patient should achieve to meet the target ventilation parameters. When the ventilation device is used in conjunction with the nitric oxide output module, the gas at the patient's end is a mixture of a first gas and a second gas. Therefore, based on the target gas flow rate and the second gas flow rate, the flow rate of the first gas output by the ventilation device to meet the target gas flow rate can be calculated and used as the target first gas flow rate.

[0069] S104. Output the first gas at the target first gas flow rate so that the gas supplied to the patient meets the requirements of the target ventilation parameters.

[0070] In this embodiment of the invention, the ventilation device outputs a first gas at a target first gas flow rate, thereby enabling the mixture of the first gas and the second gas to reach the target gas flow rate corresponding to the patient end, so that the gas supplied to the patient end meets the requirements of the target ventilation parameters.

[0071] It is understood that, based on the target ventilation parameters corresponding to the ventilation device, the embodiment of the present invention can determine the target gas flow rate expected to be input to the patient; obtain the second gas flow rate corresponding to the second gas; and jointly determine the target first gas flow rate corresponding to the first gas based on the second gas flow rate and the target gas flow rate. This achieves the determination of the target first gas flow rate for outputting the first gas by combining the target ventilation parameters set on the ventilation device and the influence of the addition of the second gas on the first gas flow rate. In this way, the ventilation device outputs the first gas at the target first gas flow rate, which ensures that the gas supplied to the patient meets the requirements of the target ventilation parameters, thereby reducing the impact of the injection of nitric oxide gas on the gas parameters of the mixed gas actually reaching the patient when the ventilation device is used in conjunction with the nitric oxide output module. Therefore, the accuracy and safety of ventilation control are improved. In some embodiments, the gas supplied to the patient meeting the requirements of the target ventilation parameters indicates that the error between the gas parameters supplied to the patient and the corresponding target ventilation parameters is less than a preset error threshold.

[0072] In some embodiments, the breathing circuit of the ventilation device includes at least one gas flow sensor; the at least one gas flow sensor is used to detect the flow rate of a first gas. For example, as... Figure 4-1 As shown, a gas flow sensor 10-5 can be installed between the gas outlet 10-3 of the first gas and the gas outlet of the second gas to measure the actual flow rate of the first gas. Alternatively, it can be as follows: Figure 4-2As shown, a gas flow sensor, gas flow sensor 10-6, and a gas flow sensor 10-7 are respectively installed on the air branch and oxygen branch of the intake branch 10-2. The actual flow rate of the first gas is calculated based on the air flow rate measured by gas flow sensor 10-6 and the oxygen flow rate measured by gas flow sensor 10-7.

[0073] In some embodiments, a first gas flow rate determined by at least one gas flow sensor characterizes the actual gas flow rate of the first gas output by the ventilation device. The ventilation device may transmit the first gas flow rate to its integrated or connected nitric oxide output module, so that the nitric oxide output module adjusts a second gas flow rate according to the actual measured first gas flow rate, so that the concentration of nitric oxide reaching the patient reaches the expected nitric oxide concentration.

[0074] In other words, to deliver an accurate nitric oxide concentration, the nitric oxide output module needs to adjust its own output second gas flow rate based on the actual flow rate of the first gas output by the ventilator. In some embodiments, the nitric oxide output module can adjust its own output second gas flow rate either periodically or in real time, as follows:

[0075] In some embodiments, the nitric oxide output module adjusts the second gas flow rate based on the average value of the first gas flow rate within a preset period, or the nitric oxide output module adjusts the second gas flow rate based on the first gas flow rate at each moment.

[0076] For example, in adjusting the second gas flow rate based on the average value of the first gas flow rate within a preset period, the first gas flow rate can be sampled multiple times within the preset period using at least one gas flow sensor. The average value of the first gas flow rate within the preset period is obtained by summing the flow rate values ​​obtained from the multiple samples and the number of samples. It can be understood that the average value of the first gas flow rate within the preset period represents the average flow rate of the first gas output by the ventilation device within the preset period. The nitric oxide output module adjusts the second gas flow rate based on the average flow rate of the first gas output by the ventilation device within the preset period, thereby achieving the desired effect. Figure 5-1 As shown, this enables the timing or periodic adjustment of the second gas flow rate. Figure 5-1 The diagram shows the second gas flow rate obtained by the nitric oxide output module in a preset cycle, which is adjusted according to the first gas flow rate. It can be seen that the second gas flow rate remains unchanged within the preset cycle under timed or periodic adjustment.

[0077] For example, in a method of adjusting the second gas flow rate based on the first gas flow rate at each moment, the nitric oxide output module can adjust the second gas flow rate based on the first gas flow rate delivered by the ventilation equipment at each moment, thereby achieving the desired effect. Figure 5-2 As shown, the nitric oxide output module tracks the gas flow rate output from the ventilation equipment in real time and dynamically. It can be seen that, under real-time adjustment, the second gas flow rate changes with the first gas flow rate at each moment.

[0078] In some embodiments, the nitric oxide output module can adjust the second gas flow rate based on the first gas flow rate and the target nitric oxide concentration. The target nitric oxide concentration represents a pre-set expected nitric oxide concentration. For example, based on the first gas flow rate at each moment, or the average value of the first gas flow rate over a preset period, the amount of gas output by the ventilator per unit time can be determined; based on the target nitric oxide concentration, the amount of carrier gas corresponding to achieving that concentration can be determined; based on the amount of carrier gas and the amount of gas output by the ventilator per unit time, the amount of second gas containing nitric oxide required to be output per unit time can be determined, thereby determining the second gas flow rate and adjusting it.

[0079] It is understandable that by adjusting the second gas flow rate according to the first gas flow rate, the nitric oxide output module can improve the accuracy of the nitric oxide concentration provided to the patient. Furthermore, based on the adjustment of the second gas flow rate by the nitric oxide output module, the second gas flow rate obtained in S102 above is the real-time flow rate of the second gas output by the nitric oxide output module.

[0080] In some embodiments, the target ventilation parameter includes a target pressure. For example, in the pressure-controlled ventilation (PCV) mode of a ventilator, the target pressure may include a preset peak inspiratory pressure (PIP) on the ventilator. The ventilator delivers air at the target pressure to effectively control airway pressure; excessively high or low airway pressure can harm the patient. Here, a pressure sensor may be provided in the breathing circuit; for example, the pressure sensor may be located near the patient. The process in S101 above, which determines the target gas flow rate at the patient end based on the target ventilation parameter corresponding to the ventilation device, may include: acquiring the airway pressure of the breathing circuit through the pressure sensor; and determining the target gas flow rate based on the airway pressure and the target pressure. In other words, the ventilation device can compare the airway pressure measured and fed back by the pressure sensor with the target pressure to determine the target gas flow rate, so that the airway pressure at the patient end meets the target pressure requirement. In some embodiments, the target pressure may include a target pressure value or a target pressure range; the airway pressure at the patient end meeting the target pressure requirement indicates that the error between the airway pressure at the patient end and the target pressure value is less than a preset pressure error threshold, or that the airway pressure at the patient end is within the target pressure range. The specific choice is made according to the actual situation, and the embodiments of the present invention do not limit it.

[0081] In some embodiments, determining the target first gas flow rate corresponding to the first gas in S103 based on the second gas flow rate and the target gas flow rate includes: determining the target first gas flow rate based on the difference between the target gas flow rate and the second gas flow rate. That is, the target first gas flow rate can be obtained by subtracting the second gas flow rate from the target gas flow rate. In this way, when the ventilation device outputs the first gas according to the target first gas flow rate, the sum of the first gas flow rate and the second gas flow rate can be kept below the target first gas flow rate determined based on the target pressure, thereby improving the safety of the ventilation process.

[0082] In some embodiments, when the ventilation device operates independently, it adjusts the flow rate of the output first gas in real time based on a comparison between the airway pressure fed back by the pressure sensor and the target pressure, so that the airway pressure at the patient's end reaches the target pressure. However, when the ventilation device is used in conjunction with a nitric oxide output module, the ventilation device cannot adjust the output flow rate of the nitric oxide output module. Furthermore, when the nitric oxide output module tracks the flow rate of the first gas output from the ventilation device, it needs to first acquire the first gas flow rate, determine the second gas flow rate based on the first gas flow rate, and then output the second gas according to the second gas flow rate. It can be seen that the adjustment of the second gas flow rate by the nitric oxide output module is actually lagging behind by one control cycle. Therefore, for the first control cycle, the flow rate of the second gas output by the nitric oxide output module cannot follow the change in the flow rate of the first gas output by the ventilation device, which may lead to excessively high airway pressure or even loss of control. Here, the control cycle represents the period during which the ventilation device periodically or periodically calculates and executes the target first gas flow rate. When calculating the target first gas velocity based on the target pressure, since the second gas velocity cannot follow the change of the first gas velocity in the first control cycle, in order to prevent the gas pressure from becoming too high instantaneously, the ventilation equipment temporarily does not output the first gas in the first control cycle.

[0083] Therefore, in some embodiments, based on the target ventilation parameters corresponding to the ventilation device, the target gas flow rate corresponding to the patient is determined and executed in the first control cycle of the ventilation device; that is, in the first control cycle, the ventilation device first determines the target gas flow rate corresponding to the patient and temporarily does not execute the output of the first gas. In each control cycle after the first control cycle, the ventilation device acquires the second gas flow rate corresponding to the second gas; based on the second gas flow rate and the target gas flow rate, the target first gas flow rate corresponding to the first gas is determined; and the first gas is output at the target first gas flow rate. Furthermore, the nitric oxide output module can adjust the second gas flow rate according to the first gas flow rate measured by at least one sensor, and begin to follow the output flow rate of the ventilation device.

[0084] This can prevent airway pressure overshoot caused by mismatch between the first and second gas flow rates during the first control cycle, thus improving the safety of the ventilation process.

[0085] In some embodiments, when the nitric oxide output module is used in conjunction with a ventilation device, the second gas flow rate may exceed the patient's required flow rate in order to achieve the target nitric oxide concentration at the patient's end. Alternatively, due to potential response delays in the nitric oxide output module or the actuators on the ventilation device, the sum of the second and first gas flow rates reaching the patient may exceed the patient's required flow rate, leading to excessively high airway pressure at the patient's end. The following ventilation methods can be used to avoid injury to the patient caused by excessive airway pressure, as follows:

[0086] In some embodiments, such as Figure 6 As shown, the expiratory branch 10-8 of the breathing circuit 10-1 is equipped with an expiratory valve 10-9; after the ventilation device outputs the first gas at the target first gas flow rate, it can obtain the second gas flow rate measured by the gas flow sensor 10-4 installed at the gas outlet of the second gas; and through at least one gas flow sensor installed on the breathing circuit (such as...) Figure 4-1 The 10-5 shown in the figure, or Figure 4-2 As shown in 10-6 and 10-7, the first gas flow rate corresponding to the first gas is determined. In this way, the ventilation device can determine the total gas flow rate based on the first gas flow rate and the second gas flow rate; based on the target gas flow rate and the total gas flow rate, the expiratory valve 10-9 is opened to reduce the airway pressure corresponding to the patient.

[0087] For example, when the total gas flow rate is greater than the target gas flow rate, the expiratory valve is opened to expel excess gas from the breathing circuit, thereby reducing the corresponding airway pressure at the patient's end. When the pressure sensor on the breathing circuit detects that the airway pressure is less than or equal to the target pressure, the expiratory valve is closed.

[0088] It is understood that, according to the actual total gas flow rate and the theoretical target gas flow rate, the expiratory valve can be controlled to expel excess gas, so that the actual airway pressure is consistent with the target pressure, avoiding damage to the patient caused by excessively high airway pressure at the patient end, thereby improving the safety of the ventilation equipment and the nitric oxide output module used together.

[0089] In some embodiments, the target ventilation parameter includes a target tidal volume. When the ventilation device is used in conjunction with a nitric oxide output module, the second gas output by the nitric oxide output module to the patient can affect the actual tidal volume reaching the patient, potentially causing drastic fluctuations or even instability in the tidal volume. Using the ventilation method provided in this embodiment, the process of determining the target first gas flow rate corresponding to the first gas in S103 above, based on the second gas flow rate and the target gas flow rate, can include: determining the target first gas flow rate based on the difference between the target gas flow rate and the second gas flow rate. That is, the ventilation device can use the target gas flow rate calculated according to the set target tidal volume. Here, the target gas flow rate represents the theoretical delivery flow rate of the first gas output by the ventilation device to achieve the target tidal volume at the patient. Furthermore, the ventilation device acquires the second gas flow rate output by the nitric oxide output module in real time and uses the difference between the target gas flow rate and the second gas flow rate as the target first gas flow rate. In this way, the ventilation device outputs the first gas at the target first gas flow rate. When used in conjunction with the nitric oxide output module, the first gas flow rate and the second gas flow rate can reach the theoretical delivery flow rate. This allows the flow rate of the first gas output by the ventilation device to be adjusted according to the second gas flow rate output by the nitric oxide output module, so that the tidal volume at the patient end meets the target tidal volume requirement set on the ventilation device.

[0090] In some embodiments, the target tidal volume may include a preset target tidal volume value or a preset target tidal volume range; the tidal volume corresponding to the patient terminal meets the requirements of the target tidal volume, indicating that the error between the tidal volume corresponding to the patient terminal and the target tidal volume is less than a preset tidal volume error threshold, or that the tidal volume corresponding to the patient terminal is within the target tidal volume range. The specific selection is made according to the actual situation, and the embodiments of the present invention do not limit it.

[0091] In some embodiments, the nitric oxide output module samples gas at a certain flow rate from the patient's breathing tubing via a monitoring pathway to monitor NO, NO2, and oxygen concentrations at the patient's end. For ventilation equipment, especially neonatal ventilation, this sampling flow rate can cause deviations in tidal volume calculations, resulting in tidal volume fluctuations. In the ventilation method provided by this invention, when the nitric oxide output module samples gas from the patient's breathing tubing at a sampling flow rate for detection, the process by which the ventilation equipment determines a target first gas flow rate based on the difference between a target gas flow rate and a second gas flow rate can include: acquiring the sampling flow rate; and determining the target first gas flow rate based on the difference between the target gas flow rate and the second gas flow rate, and the sum of this difference and the sampling flow rate.

[0092] For example, based on the connection method between the nitric oxide output module and the patient end, the breathing circuit of the patient end may include a breathing circuit connected to the nitric oxide output module, for example, including an inspiratory branch on the breathing circuit; or, including other accessories or gas lines connecting the nitric oxide output module and the patient end, the specific selection is made according to the actual situation, and the embodiments of the present invention are not limited.

[0093] In other words, the ventilation device can acquire the sampling flow rate of the gas drawn from the patient's breathing tubing by the nitric oxide output module for testing, and the second gas flow rate of the second gas output from the nitric oxide output module to the patient. Based on the target tidal volume, the target gas flow rate is calculated. Thus, the ventilation device can determine the first gas flow rate based on the target gas flow rate, the sampling flow rate, and the second gas flow rate. The ventilation device calculates the difference between the target gas flow rate and the second gas flow rate, and sums this difference with the sampling flow rate to obtain the target first gas flow rate. In this way, the ventilation device outputs the first gas at the target first gas flow rate. When used in conjunction with the nitric oxide output module, the flow rate of the first gas output by the ventilation device can be adjusted and compensated based on the second gas flow rate output by the nitric oxide output module and the sampling flow rate of the drawn gas, ensuring that the tidal volume at the patient's end meets the target tidal volume requirement set on the ventilation device.

[0094] In some embodiments, where the target ventilation parameter includes a target tidal volume, the ventilation device performs the process described above in the first control cycle of determining the target gas flow rate at the patient end based on the target ventilation parameter corresponding to the ventilation device. After determining the target gas flow rate at the patient end, the ventilation device outputs the first gas at the target gas flow rate. That is, in the first control cycle, the ventilation device first calculates the theoretical delivery flow rate based on the target tidal volume and outputs the first gas at the theoretical delivery flow rate. In each control cycle after the first control cycle, the ventilation device acquires the second gas flow rate corresponding to the second gas; based on the second gas flow rate and the target gas flow rate, it determines the target first gas flow rate corresponding to the first gas; and outputs the first gas at the target first gas flow rate. In other words, in each control cycle after the first control cycle, the ventilation device adjusts the target first gas flow rate based on the real-time acquired second gas flow rate, or based on the real-time acquired second gas flow rate and the sampling flow rate, so that when the ventilation device outputs the first gas at the target first gas flow rate, the tidal volume at the patient end can meet the target tidal volume requirement.

[0095] It is understood that, in the embodiments of the present invention, the target first gas flow rate can be determined based on the target tidal volume and the second gas flow rate, or based on the target tidal volume, the second gas flow rate and the sampling flow rate, and the first gas is output at the target first gas flow rate, so that the actual tidal volume at the patient end can meet the requirements of the target tidal volume, thereby improving the accuracy of ventilation control and the accuracy and stability of the tidal volume at the patient end.

[0096] In some embodiments, due to potential execution delays in the actuators of the ventilation device or the nitric oxide output module, the actual gas output velocity lags behind the calculated target velocity. Therefore, the ventilation device can detect the actual tidal volume at the patient end and adjust the target first gas velocity accordingly to achieve the target tidal volume. Exemplarily, the actual tidal volume at the patient end can be measured by placing a gas flow sensor near the patient end in the breathing circuit; alternatively, the actual tidal volume at the patient end can also be measured using a combination of gas flow sensors 10⁻⁴, 10⁻⁶, 10⁻⁷, and 10⁻⁹, or a combination of 10⁻⁴, 10⁻⁵, and 10⁻⁹. The ventilation device can acquire the tidal volume at the patient end corresponding to at least one inspiratory cycle; wherein the tidal volume corresponding to each inspiratory cycle can be calculated cumulatively based on the first gas velocity and the second gas velocity measured by the gas flow sensor within the inspiratory cycle. The ventilation device adjusts the target first gas velocity based on the target tidal volume and the tidal volume corresponding to at least one inspiratory cycle.

[0097] For example, the ventilation device can adjust the target first gas flow rate based on the difference between the tidal volume corresponding to each inspiratory cycle and the target tidal volume, so that the actual tidal volume at the patient's end meets the target tidal volume requirement. Alternatively, the ventilation device can adjust the target first gas flow rate based on the average tidal volume corresponding to multiple inspiratory cycles and the excess of the target tidal volume, so that the actual tidal volume at the patient's end meets the target tidal volume requirement. The inspiratory cycle can be customized according to actual needs, and this embodiment of the invention does not limit it. That is, the ventilation device can fine-tune the flow rate of the first gas output by the ventilation device at regular intervals or periods based on the target tidal volume and the actual tidal volume at the patient's end.

[0098] It is understood that the embodiments of the present invention can fine-tune the target first gas flow rate according to the target tidal volume and the actual tidal volume, thereby improving the accuracy of ventilation control and the accuracy and stability of the tidal volume at the patient end.

[0099] In some embodiments, the target ventilation parameter includes a target oxygen concentration. When a ventilation device is used in conjunction with a nitric oxide output module, the nitric oxide output module injects a second gas into the patient's breathing tubing, exemplarily, air containing a certain NO concentration. This can lead to a low oxygen concentration in the mixed gas entering the patient's end, affecting the treatment effect. This invention provides a ventilation method that, when a ventilation device and a nitric oxide output module are used in conjunction, compensates for the oxygen concentration at the patient's end to ensure that the oxygen concentration at the patient's end meets the target oxygen concentration requirement. The embodiments of this invention are described below.

[0100] In some embodiments, for Figure 1-1 Ventilation equipment 100-1 or Figure 1-2 The ventilation device 100-2 includes a nitric oxide output module 20, or the ventilation device is communicatively connected to the nitric oxide output module 20. Furthermore, the ventilation device also includes a breathing circuit 10-1 connected to the patient, the ventilation device being used to input air and oxygen into the breathing circuit 10-1 respectively, the air and oxygen mixing in the breathing circuit 10-1 to form a first gas which is then output to the patient; the nitric oxide output module 20 is used to output a second gas containing nitric oxide to the patient; the ventilation method provided in this embodiment of the invention can be as follows... Figure 7 As shown, including S201-S204, as follows:

[0101] S201. Based on the target gas flow rate and target oxygen concentration corresponding to the ventilation equipment, determine the target carrier gas flow rate and the target oxygen flow rate corresponding to the oxygen.

[0102] In this embodiment of the invention, the target gas flow rate and target oxygen concentration corresponding to the ventilation device are the gas flow rate and oxygen concentration set by the operator on the ventilation device. Based on the target gas flow rate and target oxygen concentration, the theoretical flow rate of oxygen entering the breathing circuit to meet the target oxygen concentration requirement at the patient end can be calculated, as well as the theoretical flow rate of other gases besides oxygen, i.e., the carrier gas of oxygen; the theoretical flow rate corresponding to oxygen is taken as the target oxygen flow rate, and the theoretical flow rate corresponding to the carrier gas is taken as the target carrier gas flow rate.

[0103] S202, Obtain the second gas flow rate corresponding to the second gas.

[0104] Here, the process of obtaining the second gas flow rate in S202 is the same as that in S102 above, and will not be repeated here.

[0105] S203. Determine the target air velocity corresponding to the air based on the target carrier gas velocity and the second gas velocity.

[0106] In this embodiment of the invention, since the target carrier gas flow rate characterizes the theoretical flow rate of other gases besides oxygen in order to make the oxygen concentration at the patient end meet the target oxygen concentration requirement, and other gases besides oxygen include air and the second gas output by the nitric oxide output module, the theoretical flow rate of air can be determined based on the target carrier gas flow rate and the second gas flow rate, and used as the target air flow rate.

[0107] In some embodiments, the target air velocity can be determined based on the difference between the target carrier gas velocity and the second gas velocity. Alternatively, the target air velocity can be determined based on the difference between the target carrier gas velocity and the second gas velocity, combined with a preset empirical fluctuation value. The specific choice depends on the actual situation, and this embodiment of the invention does not impose limitations.

[0108] S204. Introduce air into the breathing circuit at the target air flow rate and oxygen into the breathing circuit at the target oxygen flow rate so that the oxygen concentration at the patient end meets the target oxygen concentration requirement.

[0109] In this embodiment of the invention, the ventilation device controls the air flow rate with a target air flow rate to input air into the breathing circuit, and controls the oxygen flow rate with a target oxygen flow rate to input oxygen into the breathing circuit. Combined with the nitric oxide output module inputting a second gas into the breathing circuit with a second gas flow rate, the oxygen concentration of the gas output to the patient can meet the target oxygen concentration requirements.

[0110] In some embodiments, the target oxygen concentration may include a preset target oxygen concentration value or a preset target oxygen concentration range; the oxygen concentration at the patient end meeting the target oxygen concentration requirement indicates that the error between the oxygen concentration at the patient end and the target oxygen concentration is less than a preset oxygen concentration error threshold, or that the oxygen concentration at the patient end is within the target oxygen concentration range. The specific selection is made according to the actual situation, and the embodiments of the present invention do not limit it.

[0111] It is understood that, in the embodiments of the present invention, the target first gas flow rate can be determined based on the target oxygen concentration, the target gas flow rate and the second gas flow rate, and the first gas is output at the target first gas flow rate, so that the actual oxygen concentration provided to the patient can meet the requirements of the target oxygen concentration, thereby improving the accuracy of ventilation control and the accuracy and stability of the oxygen concentration at the patient end.

[0112] It should be noted that when the ventilation equipment and the nitric oxide output module are used in conjunction, the ventilation equipment can determine the first gas flow rate corresponding to the first gas through at least one gas flow sensor installed on the breathing circuit; the first gas flow rate is then transmitted to the nitric oxide output module, so that the nitric oxide output module adjusts the second gas flow rate according to the first gas flow rate. Specifically, the nitric oxide output module adjusts the second gas flow rate based on the average value of the first gas flow rate within a preset period, or it adjusts the second gas flow rate based on the first gas flow rate at each moment. In other words, the nitric oxide output module can adjust its own output second gas flow rate according to the first gas flow rate output by the ventilation equipment, thereby performing timed or dynamic tracking of the first gas flow rate and improving the accuracy and stability of the nitric oxide gas concentration at the patient end.

[0113] In practical applications, the second gas flow rate is tracked in real time based on the first gas flow rate. However, considering that the actuators of nitric oxide output modules, such as proportional valves in NO therapy devices, require response time and cannot be completely tracked, and that the actuators of ventilation equipment, such as ventilators, also have delays, the actual air flow rate and the target air flow rate, as well as the actual oxygen flow rate and the target oxygen flow rate, cannot be completely tracked. Due to these factors, the actual oxygen concentration in the mixed gas reaching the patient is inaccurate. Therefore, this embodiment of the invention can calculate the actual oxygen concentration at the patient's end based on the second gas flow rate, the actual air flow rate output by the ventilation equipment, and the actual oxygen flow rate output. Based on the actual oxygen concentration and the target oxygen concentration, the ratio of the output air flow rate and oxygen flow rate is adjusted periodically or at fixed intervals to ensure that the actual oxygen concentration reaches the target oxygen concentration.

[0114] In some embodiments, such as Figure 8-1 and 8-2 As shown, the inspiratory branch 10-2 in the breathing circuit 10-1 includes: an air branch 10-21, an oxygen branch 10-22, and a main inspiratory branch 10-23. The air branch 10-21 and the oxygen branch 10-22 are respectively used to input air and oxygen into the main inspiratory branch 10-23. The air and oxygen are mixed in the main inspiratory branch 10-23 to form a first gas, which is then output to the patient. For example, the oxygen branch 10-22 may include a high-pressure oxygen branch of the ventilator; the air branch 10-21 may include a low-pressure air branch of the ventilator. Multiple gas flow sensors (such as...) are installed on the air branch 10-21 and the oxygen branch 10-22. Figure 8-1 The gas flow sensors shown in 10-6 and 10-7, or, as... Figure 8-2Gas flow sensors 10-7 and 10-10 (shown in the diagram) are used to detect air flow rate and oxygen flow rate, respectively. For example, air flow rate is measured by gas flow sensor 10-6, and oxygen flow rate is measured by gas flow sensor 10-7. Alternatively, oxygen flow rate is measured by gas flow sensor 10-7, and air flow rate is obtained by the difference between the gas flow rates measured by gas flow sensor 10-10 and gas flow sensor 10-7. The second gas flow rate is measured by gas flow sensor 10-4 installed at the gas outlet of the second gas. After the ventilation device inputs air into the breathing circuit at the target air flow rate and oxygen into the breathing circuit at the target oxygen flow rate, the following method can also be performed:

[0115] Obtain airflow rate and oxygen flow rate; determine the corresponding oxygen concentration at the patient end based on the airflow rate, oxygen flow rate, and second gas flow rate; adjust the target airflow rate and / or target oxygen flow rate based on the corresponding oxygen concentration at the patient end and the target oxygen concentration.

[0116] Here, the ventilation equipment calculates the actual oxygen concentration received by the patient based on the measured airflow rate, oxygen flow rate, and second gas flow rate, which is then used as the corresponding oxygen concentration at the patient's end. The ventilation equipment adjusts the target airflow rate and / or target oxygen flow rate based on the difference between the patient's oxygen concentration and the target oxygen concentration. This adjusts the ratio of oxygen to other gases in the inspiratory branch of the gas mixture, ensuring that the actual oxygen concentration received by the patient meets the target oxygen concentration requirement.

[0117] Understandably, ventilation equipment adjusts the target airflow rate and / or target oxygen flow rate based on the actual oxygen concentration, further improving the accuracy and stability of ventilation parameters during ventilation.

[0118] In practical applications, the second gas output by the nitric oxide output module may, upon reaching the patient, experience a discrepancy between the actual nitric oxide concentration provided and the expected concentration due to losses or leaks in the gas transmission tubing. This invention provides a ventilation method applied to a nitric oxide output module. Referring to the structural schematic diagram of any of the ventilation devices in the foregoing embodiments, the nitric oxide output module is communicatively connected to the ventilation device; alternatively, the ventilation device includes a nitric oxide output module, which is used to output a first gas containing air and oxygen to the patient at a target first gas flow rate via a breathing circuit connected to the patient; the nitric oxide output module is used to output a second gas containing nitric oxide to the patient at a target second gas flow rate.

[0119] Here, the target second gas flow rate of the nitric oxide output module may include the second gas flow rate preset by the user on the nitric oxide output module; or, in conjunction with the foregoing embodiments, the target second gas flow rate may include the second gas flow rate determined by the nitric oxide output module adjusting its own output second gas flow rate according to the first gas flow rate output by the ventilation equipment.

[0120] In this embodiment, the nitric oxide output module is also used to detect the nitric oxide concentration of the gas at the patient end and determine the nitric oxide concentration at the patient end. For example, the concentration of nitric oxide in the gas at the patient end, i.e., the mixture of the first gas and the second gas, can be detected by a gas concentration sensor installed at the patient end to determine the nitric oxide concentration at the patient end; alternatively, the nitric oxide output module can draw gas from the breathing tubing at the patient end through a gas monitoring path; the gas monitoring path is connected to a gas concentration sensor to detect the nitric oxide concentration in the drawn gas in real time, which is used as the nitric oxide concentration at the patient end.

[0121] In this embodiment, the nitric oxide output module can adjust the target second gas flow rate and / or the nitric oxide concentration in the second gas based on the nitric oxide concentration at the patient's end and the target nitric oxide concentration. Since the nitric oxide concentration at the patient's end reflects the actual nitric oxide concentration supplied to the patient, it can be determined whether the nitric oxide concentration at the patient's end meets the target nitric oxide concentration requirement based on the patient's nitric oxide concentration and the target nitric oxide concentration. Here, the target nitric oxide concentration represents the expected nitric oxide concentration supplied to the patient. For example, the target nitric oxide concentration can be obtained by acquiring the nitric oxide concentration preset by the user on the nitric oxide output module. The target nitric oxide concentration may include a preset target nitric oxide concentration value or a preset target nitric oxide concentration range, which is selected according to the actual situation, and this embodiment of the invention does not limit this.

[0122] For example, when the nitric oxide concentration at the patient end is greater than the target nitric oxide concentration, the target second gas flow rate and / or the nitric oxide concentration in the second gas are reduced; when the nitric oxide concentration at the patient end is less than the target nitric oxide concentration, the target second gas flow rate and / or the nitric oxide concentration in the second gas are reduced, so that the nitric oxide concentration at the patient end meets the target nitric oxide concentration requirement. In some embodiments, the nitric oxide concentration at the patient end meeting the target nitric oxide concentration requirement indicates that the error between the nitric oxide concentration at the patient end and the target nitric oxide concentration value is less than a preset concentration error threshold, or that the nitric oxide concentration at the patient end is within the target nitric oxide concentration range. The specific selection is made according to the actual situation, and the embodiments of the present invention are not limited thereto.

[0123] In this way, by adjusting the target second gas flow rate and / or the nitric oxide concentration in the second gas output by the nitric oxide output module based on the real-time detection of the nitric oxide concentration at the patient end, precise closed-loop control is achieved, improving the accuracy and stability of the nitric oxide concentration in the gas supplied to the patient end.

[0124] Alternatively, the nitric oxide output module can transmit the nitric oxide concentration at the patient's end to the ventilation equipment, allowing the ventilation equipment to adjust the target first gas flow rate based on the nitric oxide concentration at the patient's end, thus ensuring that the nitric oxide concentration at the patient's end meets the target nitric oxide concentration requirement. The nitric oxide concentration can be transmitted by the nitric oxide output module to the ventilation equipment, or it can be read by the ventilation equipment from the gas concentration sensor of the nitric oxide output module. Since the gas at the patient's end is a mixture of a first gas and a second gas, adjusting the target first gas flow rate based on the nitric oxide concentration at the patient's end can also achieve the effect of ensuring that the nitric oxide concentration at the patient's end meets the target nitric oxide concentration requirement. For example, if the nitric oxide concentration at the patient's end is greater than the target nitric oxide concentration, the target first gas flow rate is increased; if the nitric oxide concentration at the patient's end is less than the target nitric oxide concentration, the target first gas flow rate is decreased.

[0125] Alternatively, the nitric oxide output module can adjust the target second gas flow rate and / or the nitric oxide concentration in the second gas based on the nitric oxide concentration at the patient's end, and transmit the nitric oxide concentration at the patient's end to the ventilation equipment, so that the ventilation equipment adjusts the target first gas flow rate according to the nitric oxide concentration at the patient's end. In other words, the nitric oxide output module and the ventilation equipment work together to ensure that the nitric oxide concentration at the patient's end meets the target nitric oxide concentration requirement. The specific selection depends on the actual situation, and this embodiment of the invention does not limit the choice.

[0126] It should be noted that the above-mentioned nitric oxide output module adjusts the target second gas flow rate and / or the nitric oxide concentration in the second gas, and the ventilation device adjusts the target first gas flow rate. This adjustment can be made in real time based on the real-time detected nitric oxide concentration at the patient end, or it can be adjusted periodically. The specific choice depends on the actual situation, and the embodiments of the present invention do not limit this.

[0127] Accordingly, embodiments of the present invention provide a ventilation method applied to a ventilation device, the ventilation device including: a nitric oxide output module, or the ventilation device being communicatively connected to the nitric oxide output module; the ventilation device being used to output a first gas containing air and oxygen to the patient end at a target first gas flow rate via a breathing circuit connected to the patient end; the nitric oxide output module being used to output a second gas containing nitric oxide to the patient end; the nitric oxide output module being further used to detect the nitric oxide concentration of the gas at the patient end, and determine the nitric oxide concentration at the patient end; the method includes:

[0128] Obtain the nitric oxide concentration at the patient end; adjust the target first gas flow rate based on the nitric oxide concentration at the patient end.

[0129] Here, this embodiment describes a method applied to a ventilation device. The process of the ventilation device acquiring the nitric oxide concentration at the patient's end and adjusting the target first gas flow rate based on the nitric oxide concentration at the patient's end is consistent with the execution process of the ventilation device described in the above embodiment, and will not be repeated here.

[0130] Understandably, by adjusting the target second gas flow rate and / or the nitric oxide concentration in the second gas based on the real-time detected nitric oxide concentration at the patient end, and by adjusting the target first gas flow rate of the first gas output by the ventilation equipment, closed-loop regulation is achieved through concentration feedback, thereby improving the accuracy and stability of the nitric oxide concentration in the gas supplied to the patient end.

[0131] This invention provides a ventilation device, such as... Figure 9-1 As shown, the ventilation device 100-3 includes: a nitric oxide output module 20 and a breathing circuit 10-1 connected to the patient end; the ventilation device 100-3 is used to output a first gas containing air and oxygen to the patient end through the breathing circuit 10-1; the nitric oxide output module 20 is used to output a second gas containing nitric oxide to the patient end; a gas flow sensor 10-4 is provided at the gas outlet of the second gas; wherein,

[0132] A gas flow sensor 10-4 is installed at the gas outlet of the second gas to obtain the flow rate of the second gas.

[0133] The ventilation device 100-3 is further configured to determine the target gas flow rate corresponding to the patient end based on the target ventilation parameters set by the user; determine the target first gas flow rate corresponding to the first gas based on the second gas flow rate and the target gas flow rate; and output the first gas at the target first gas flow rate so that the gas provided to the patient end meets the requirements of the target ventilation parameters.

[0134] This invention provides a ventilation device, such as... Figure 9-2 As shown, the ventilation device 100-4 is communicatively connected to the nitric oxide output module 20; the ventilation device 100-4 includes: a breathing circuit 10-1 connected to the patient end; the ventilation device 100-4 is used to output a first gas containing air and oxygen to the patient end through the breathing circuit 10-1; the nitric oxide output module 20 is used to output a second gas containing nitric oxide to the patient end; a gas flow sensor 10-4 is provided at the gas outlet of the second gas; wherein,

[0135] The nitric oxide output module 20 is used to obtain the second gas flow rate corresponding to the second gas through the gas flow sensor 10-4 set at the gas outlet of the second gas, and transmit it to the ventilation device 100-4.

[0136] The ventilation device 100-4 is further configured to determine the target gas flow rate corresponding to the patient end based on the target ventilation parameters set by the user; determine the target first gas flow rate corresponding to the first gas based on the second gas flow rate and the target gas flow rate; and output the first gas at the target first gas flow rate so that the gas provided to the patient end meets the requirements of the target ventilation parameters.

[0137] In some embodiments, the target ventilation parameter includes: target pressure; the ventilation device 100-3 or the ventilation device 100-4 is further configured to determine the target first gas velocity based on the difference between the target gas velocity and the second gas velocity.

[0138] In some embodiments, the target ventilation parameters include: target pressure; at least one gas flow sensor is provided on the breathing circuit; an expiratory valve is provided in the expiratory branch of the breathing circuit; the at least one gas flow sensor is used to detect the flow rate of the first gas; the second gas flow rate is measured by a gas flow sensor provided at the gas outlet of the second gas; the ventilation device 100-3 or the ventilation device 100-4 is further used to determine the first gas flow rate corresponding to the first gas after outputting the first gas at the target first gas flow rate by means of the at least one gas flow sensor; determine the total gas flow rate according to the first gas flow rate and the second gas flow rate; and control the opening of the expiratory valve according to the target gas flow rate and the total gas flow rate to reduce the gas pressure corresponding to the patient end.

[0139] In some embodiments, the target ventilation parameter includes: target pressure; the ventilation device 100-3 or the ventilation device 100-4 is further configured to perform, in the first control cycle: a process of determining the target gas flow rate corresponding to the patient end based on the target ventilation parameter corresponding to the ventilation device; and in each control cycle after the first control cycle: a process of obtaining the second gas flow rate corresponding to the second gas; determining the target first gas flow rate corresponding to the first gas based on the second gas flow rate and the target gas flow rate; and outputting the first gas at the target first gas flow rate.

[0140] In some embodiments, the target ventilation parameters include: target pressure; a pressure sensor is provided on the breathing circuit; the ventilation device 100-3 or the ventilation device 100-4 is further configured to obtain the airway pressure of the breathing circuit through the pressure sensor; and determine the target gas flow rate based on the airway pressure and the target pressure.

[0141] In some embodiments, the target ventilation parameter includes: target tidal volume; the ventilation device 100-3 or the ventilation device 100-4 is further configured to determine the target first gas velocity based on the difference between the target gas velocity and the second gas velocity.

[0142] In some embodiments, the nitric oxide output module 20 is further configured to extract gas from the breathing tubing at the patient end at a sampling flow rate for detection, and the ventilation device 100-3 or the ventilation device 100-4 is further configured to acquire the sampling flow rate; and determine the target first gas flow rate based on the difference between the target gas flow rate and the second gas flow rate, and the difference between the difference and the sampling flow rate.

[0143] In some embodiments, the ventilation device 100-3 or the ventilation device 100-4 is further configured to, after determining the target first gas flow rate, acquire the tidal volume at the patient end corresponding to at least one inspiratory cycle; and adjust the target first gas flow rate according to the target tidal volume and the tidal volume corresponding to the at least one inspiratory cycle.

[0144] In some embodiments, the target ventilation parameter includes a target tidal volume; the ventilation device 100-3 or the ventilation device 100-4 is further configured to perform, in the first control cycle: determining the target gas flow rate corresponding to the patient end based on the target ventilation parameter corresponding to the ventilation device, and outputting the first gas at the target gas flow rate after determining the target gas flow rate corresponding to the patient end; and in each control cycle after the first control cycle, performing: acquiring the second gas flow rate corresponding to the second gas; determining the target first gas flow rate corresponding to the first gas based on the second gas flow rate and the target gas flow rate; and outputting the first gas at the target first gas flow rate.

[0145] In some embodiments, the ventilation device 100-3 or the ventilation device 100-4 is further configured to determine the first gas flow rate corresponding to the first gas by means of at least one gas flow sensor provided on the breathing circuit; and transmit the first gas flow rate to the nitric oxide output module 20 so that the nitric oxide output module 20 adjusts the second gas flow rate according to the first gas flow rate.

[0146] In some embodiments, the nitric oxide output module 20 is further configured to adjust the second gas flow rate according to the average value of the first gas flow rate within a preset period, or the nitric oxide output module 20 is further configured to adjust the second gas flow rate according to the first gas flow rate at each moment.

[0147] based on Figure 9-1 This invention provides a ventilation device 100-3, comprising: a nitric oxide output module 20, and a breathing circuit 10-1 connected to the patient end. The ventilation device 100-3 is used to input air and oxygen into the breathing circuit 10-1, respectively, wherein the air and oxygen are mixed in the breathing circuit 10-1 to form a first gas, which is then output to the patient end. The nitric oxide output module 20 is used to output a second gas containing nitric oxide to the patient end.

[0148] A gas flow sensor 10-4 is installed at the gas outlet of the second gas to obtain the flow rate of the second gas.

[0149] The ventilation device 100-3 is further configured to determine a target carrier gas flow rate and a target oxygen flow rate corresponding to oxygen based on the target gas flow rate and target oxygen concentration set by the user; determine a target air flow rate corresponding to air based on the target carrier gas flow rate and the second gas flow rate; input air into the breathing circuit 10-1 at the target air flow rate, and input oxygen into the breathing circuit 10-1 at the target oxygen flow rate, so that the oxygen concentration at the patient end meets the requirement of the target oxygen concentration.

[0150] based on Figure 9-2 This invention provides a ventilation device 100-4, comprising: a nitric oxide output module 20, and a breathing circuit 10-1 connected to the patient end. The ventilation device 100-5 is used to input air and oxygen into the breathing circuit 10-1, respectively, wherein the air and oxygen are mixed in the breathing circuit 10-1 to form a first gas, which is then output to the patient end. The nitric oxide output module 20 is used to output a second gas containing nitric oxide to the patient end.

[0151] A gas flow sensor 10-4 is installed at the gas outlet of the second gas to obtain the flow rate of the second gas.

[0152] The ventilation device 100-4 is further configured to determine a target carrier gas flow rate and a target oxygen flow rate corresponding to oxygen based on the target gas flow rate and target oxygen concentration set by the user; determine a target air flow rate corresponding to air based on the target carrier gas flow rate and the second gas flow rate; input air into the breathing circuit 10-1 at the target air flow rate, and input oxygen into the breathing circuit 10-1 at the target oxygen flow rate, so that the oxygen concentration at the patient end meets the requirement of the target oxygen concentration.

[0153] In some embodiments, the ventilation device 100-3 or the ventilation device 100-4 is further configured to determine the target air velocity based on the difference between the target carrier gas velocity and the second gas velocity.

[0154] In some embodiments, the breathing circuit 10-1 is provided with a gas flow sensor for detecting air flow rate and oxygen flow rate respectively; the second gas flow rate is measured by a gas flow sensor 10-4 provided at the gas outlet of the second gas; the ventilation device 100-3 or the ventilation device 100-4 is further used to input air into the breathing circuit 10-1 at the target air flow rate and oxygen into the breathing circuit 10-1 at the target oxygen flow rate, and then obtain the air flow rate and oxygen flow rate; determine the oxygen concentration corresponding to the patient end based on the air flow rate, the oxygen flow rate and the second gas flow rate; and adjust the target air flow rate and / or the target oxygen flow rate based on the oxygen concentration corresponding to the patient end and the target oxygen concentration.

[0155] In some embodiments, the ventilation device 100-3 or the ventilation device 100-4 is further configured to determine the first gas flow rate corresponding to the first gas by means of at least one gas flow sensor provided on the breathing circuit 10-1; and transmit the first gas flow rate to the nitric oxide output module 20 so that the nitric oxide output module 20 adjusts the second gas flow rate according to the first gas flow rate.

[0156] In some embodiments, the nitric oxide output module 20 is further configured to adjust the second gas flow rate according to the average value of the first gas flow rate within a preset period, or the nitric oxide output module 20 is further configured to adjust the second gas flow rate according to the first gas flow rate at each moment.

[0157] This invention provides a nitric oxide output module, see reference. Figure 9-1 or Figure 9-2 The nitric oxide output module 20 is communicatively connected to the ventilation device 100-4, or the ventilation device 100-3 includes the nitric oxide output module 30. The ventilation device 100-3 or the ventilation device 100-4 is used to output a first gas containing air and oxygen to the patient end at a target first gas flow rate via a breathing circuit connected to the patient end; the nitric oxide output module 20 is used to output a second gas containing nitric oxide to the patient end at a target second gas flow rate. In this embodiment, the nitric oxide output module 20 is also used to detect the nitric oxide concentration of the gas at the patient end to determine the nitric oxide concentration at the patient end; the nitric oxide output module 20 is also used for:

[0158] Based on the nitric oxide concentration at the patient end and the target nitric oxide concentration, the target second gas flow rate and / or the nitric oxide concentration in the second gas are adjusted to ensure that the nitric oxide concentration at the patient end meets the target nitric oxide concentration requirement; and / or, the nitric oxide concentration at the patient end is transferred to the ventilation device 100-3 or the ventilation device 100-4, so that the ventilation device 100-3 or the ventilation device 100-4 adjusts the target first gas flow rate based on the nitric oxide concentration at the patient end and the target nitric oxide concentration to ensure that the nitric oxide concentration at the patient end meets the target nitric oxide concentration requirement.

[0159] This invention provides a ventilation device, see reference. Figure 9-1 or Figure 9-2 The ventilation device 100-3 includes a nitric oxide output module 20, or the ventilation device 100-4 is communicatively connected to the nitric oxide output module 20; the ventilation device 100-3 or the ventilation device 100-4 is used to output a first gas containing air and oxygen to the patient end through a breathing circuit connected to the patient end at a target first gas flow rate; the nitric oxide output module 20 is used to output a second gas containing nitric oxide to the patient end. In this embodiment, the nitric oxide output module 20 is also used to detect the nitric oxide concentration of the gas at the patient end and determine the nitric oxide concentration at the patient end; the ventilation device 100-3 or the ventilation device 100-4 is also used to:

[0160] Obtain the nitric oxide concentration at the patient end; based on the nitric oxide concentration at the patient end and the target nitric oxide concentration, adjust the target first gas flow rate so that the nitric oxide concentration at the patient end meets the requirement of the target nitric oxide concentration.

[0161] It should be noted that the descriptions of the above embodiments of the ventilation equipment and nitric oxide output module are similar to the descriptions of the above embodiments of the ventilation method applied to the ventilation equipment and the nitric oxide output module, and have similar beneficial effects. For any technical details not disclosed in the embodiments of the ventilation equipment and nitric oxide output module of this invention, please refer to the descriptions of the embodiments of the ventilation method applied to the ventilation equipment and the nitric oxide output module of this invention for understanding.

[0162] Those skilled in the art will understand that embodiments of the present invention can be provided as methods, systems, or computer program products. Therefore, the present invention can take the form of hardware embodiments, software embodiments, or embodiments combining software and hardware aspects. Furthermore, the present invention can take the form of a computer program product embodied on one or more computer-usable storage media (including, but not limited to, disk storage and optical storage) containing computer-usable program code.

[0163] This invention is described with reference to flowchart illustrations and / or block diagrams of methods, apparatus (systems), and computer program products according to embodiments of the invention. It will be understood that each block of the flowchart illustrations and / or block diagrams, and combinations of blocks in the flowchart illustrations and / or block diagrams, can be implemented by computer program instructions. These computer program instructions can be provided to a processor of a general-purpose computer, special-purpose computer, embedded processor, or other programmable data processing apparatus to produce a machine, such that the instructions, which execute via the processor of the computer or other programmable data processing apparatus, create means for implementing the functions specified in one or more blocks of the flowchart illustrations and / or one or more blocks of the block diagrams.

[0164] These computer program instructions may also be stored in a computer-readable storage medium that can direct a computer or other programmable data processing device to function in a particular manner, such that the instructions stored in the computer-readable storage medium produce an article of manufacture including instruction means that implement the functions specified in one or more flowcharts and / or one or more block diagrams.

[0165] These computer program instructions may also be loaded onto a computer or other programmable data processing apparatus to cause a series of operational steps to be performed on the computer or other programmable apparatus to produce a computer-implemented process, such that the instructions, which execute on the computer or other programmable apparatus, provide steps for implementing the functions specified in one or more flowcharts and / or one or more block diagrams.

[0166] The above description is merely a preferred embodiment of the present invention and is not intended to limit the scope of protection of the present invention. Any modifications, equivalent substitutions, and improvements made within the spirit and scope of the present invention are included within the scope of protection of the present invention.

Claims

1. A method of ventilation, applied to a ventilation device, characterized in that, The ventilation device comprises: a nitric oxide output module, or the ventilation device is communicatively connected with the nitric oxide output module; the ventilation device further comprises: a breathing circuit connected with a patient end, the ventilation device is used for outputting a first gas containing air and oxygen to the patient end through the breathing circuit; the nitric oxide output module is used for outputting a second gas containing nitric oxide to the patient end; the second gas is connected between the first gas and the patient end; the method comprises: determining a target gas flow rate corresponding to the patient end based on a target ventilation parameter corresponding to the ventilation device; obtaining a second gas flow rate corresponding to the second gas; determining a target first gas flow rate corresponding to the first gas based on the second gas flow rate and the target gas flow rate; outputting the first gas at the target first gas flow rate, so that the gas provided to the patient end meets the requirements of the target ventilation parameter.

2. The method of claim 1, wherein, The target ventilation parameter comprises: a target pressure; the determination of the target first gas flow rate based on the second gas flow rate and the target gas flow rate comprises: determining the target first gas flow rate according to the difference between the target gas flow rate and the second gas flow rate.

3. The method of claim 1, wherein, The target ventilation parameter comprises: a target pressure; at least one gas flow sensor is arranged on the breathing circuit; an expiratory branch of the breathing circuit is provided with an expiratory valve; the at least one gas flow sensor is used for detecting the flow rate of the first gas; the second gas flow rate is measured by a gas flow sensor arranged at the gas outlet of the second gas; after the first gas is outputted at the target first gas flow rate, the method further comprises: determining a first gas flow rate corresponding to the first gas by the at least one gas flow sensor; determining a total gas flow rate according to the first gas flow rate and the second gas flow rate; controlling the expiratory valve to be opened according to the target gas flow rate and the total gas flow rate, so as to reduce the gas pressure corresponding to the patient end.

4. The method of claim 1, wherein, The target ventilation parameter comprises: a target pressure; the determination of the target gas flow rate corresponding to the patient end based on the target ventilation parameter corresponding to the ventilation device is performed in a first control period of the ventilation device; The obtaining of the second gas flow rate corresponding to the second gas, the determination of the target first gas flow rate corresponding to the first gas based on the second gas flow rate and the target gas flow rate, and the outputting of the first gas at the target first gas flow rate are performed in each control period after the first control period.

5. The method according to any one of claims 1 to 4, characterized in that, The target ventilation parameter comprises: a target pressure; a pressure sensor is arranged on the breathing circuit; the determination of the target gas flow rate corresponding to the patient end based on the target ventilation parameter corresponding to the ventilation device comprises: obtaining an airway pressure of the breathing circuit by the pressure sensor; determining the target gas flow rate according to the airway pressure and the target pressure.

6. The method of claim 1, wherein, The target ventilation parameter comprises a target tidal volume; the determining the target first gas flow rate based on the second gas flow rate and the target gas flow rate comprises: determining the target first gas flow rate based on a difference between the target gas flow rate and the second gas flow rate.

7. The method of claim 6, wherein, The nitric oxide output module is further configured to draw gas from the breathing circuit of the patient end at a sampling flow rate for detection, and the determining the target first gas flow rate based on the difference between the target gas flow rate and the second gas flow rate comprises: obtaining the sampling flow rate; determining the target first gas flow rate based on a sum of the difference between the target gas flow rate and the second gas flow rate and the sampling flow rate.

8. The method according to claim 6 or 7, characterized in that, After the determining the target first gas flow rate, the method further comprises: obtaining a tidal volume corresponding to at least one inspiration cycle of the patient end; adjusting the target first gas flow rate based on the target tidal volume and the tidal volume corresponding to the at least one inspiration cycle.

9. The method according to claim 6 or 7, characterized in that, The target ventilation parameter comprises a target tidal volume; the determining the target gas flow rate corresponding to the patient end based on the target ventilation parameter corresponding to the ventilation device is performed in a first control cycle of the ventilation device; wherein, after the determining the target gas flow rate corresponding to the patient end, the method further comprises: outputting the first gas at the target gas flow rate. The obtaining the second gas flow rate corresponding to the second gas; the determining the target first gas flow rate corresponding to the first gas based on the second gas flow rate and the target gas flow rate; the outputting the first gas at the target first gas flow rate is performed in each control cycle after the first control cycle.

10. The method according to any one of claims 1 to 4, or claim 6 or 7, wherein, The method further comprises: determining a first gas flow rate corresponding to the first gas by at least one gas flow sensor arranged on the breathing circuit; transferring the first gas flow rate to the nitric oxide output module, so that the nitric oxide output module adjusts the second gas flow rate based on the first gas flow rate.

11. The method of claim 10, wherein, The nitric oxide output module adjusts the second gas flow rate based on an average value of the first gas flow rate in a preset period, or the nitric oxide output module adjusts the second gas flow rate based on the first gas flow rate at each moment.

12. A method of ventilation for use with a ventilation device, the method comprising: The ventilation device comprises a nitric oxide output module, or the ventilation device is communicatively connected with a nitric oxide output module; the ventilation device further comprises a breathing circuit connected with the patient end, the ventilation device is configured to input air and oxygen into the breathing circuit respectively, and the air and the oxygen are mixed into the first gas in the breathing circuit and output to the patient end; the nitric oxide output module is configured to output the second gas containing nitric oxide to the patient end; the second gas is connected between the first gas delivered and the patient end; the method comprises: determining a target carrier gas flow rate and a target oxygen flow rate corresponding to oxygen based on a target gas flow rate and a target oxygen concentration corresponding to the ventilation device; obtaining a second gas flow rate corresponding to the second gas; determining a target air flow rate corresponding to air according to the target carrier gas flow rate and the second gas flow rate; inputting air into the breathing circuit at the target air flow rate and inputting oxygen into the breathing circuit at the target oxygen flow rate so as to make the oxygen concentration at the patient end meet the requirement of the target oxygen concentration.

13. The method of claim 12, wherein, The method further comprises: determining the target air flow rate according to the difference between the target carrier gas flow rate and the second gas flow rate.

14. The method according to claim 12 or 13, characterized in that, The breathing circuit is provided with gas flow sensors for detecting air flow rate and oxygen flow rate respectively; the second gas flow rate is measured by a gas flow sensor arranged at the gas outlet of the second gas; after the air is inputted into the breathing circuit at the target air flow rate and the oxygen is inputted into the breathing circuit at the target oxygen flow rate, the method further comprises: obtaining air flow rate and oxygen flow rate; determining the oxygen concentration corresponding to the patient end according to the air flow rate, the oxygen flow rate and the second gas flow rate; adjusting the target air flow rate and / or the target oxygen flow rate according to the oxygen concentration corresponding to the patient end and the target oxygen concentration.

15. A method of ventilation for use with a nitric oxide delivery module, comprising: The ventilation device is connected in communication with the nitric oxide output module, and is configured to output a first gas containing air and oxygen to the patient end at a target first gas flow rate through a breathing circuit connected with the patient end; the nitric oxide output module is configured to output a second gas containing nitric oxide to the patient end at a target second gas flow rate; the second gas is connected between the first gas being delivered and the patient end; the nitric oxide output module is further configured to detect the concentration of nitric oxide in the gas at the patient end to determine the concentration of nitric oxide at the patient end; the method comprises: adjusting the target second gas flow rate and / or the concentration of nitric oxide in the second gas based on the concentration of nitric oxide at the patient end and a target concentration of nitric oxide so as to make the concentration of nitric oxide at the patient end meet the requirement of the target concentration of nitric oxide; and / or, transmitting the concentration of nitric oxide at the patient end to the ventilation device so that the ventilation device adjusts the target first gas flow rate based on the concentration of nitric oxide at the patient end and the target concentration of nitric oxide so as to make the concentration of nitric oxide at the patient end meet the requirement of the target concentration of nitric oxide.

16. A method of ventilation for use with a ventilation device, the method comprising: The ventilation device comprises a nitric oxide output module; the ventilation device is configured to output a first gas containing air and oxygen to the patient end at a target first gas flow rate through a breathing circuit connected with the patient end; the nitric oxide output module is configured to output a second gas containing nitric oxide to the patient end; the second gas is connected between the first gas being delivered and the patient end; the nitric oxide output module is further configured to detect the concentration of nitric oxide in the gas at the patient end to determine the concentration of nitric oxide at the patient end; the method comprises: obtaining the concentration of nitric oxide at the patient end; Adjust the target first gas flow rate based on the patient end nitric oxide concentration and the target nitric oxide concentration, so that the patient end nitric oxide concentration meets the requirements of the target nitric oxide concentration.

17. A ventilation device, characterized in that The ventilation device comprises a nitric oxide output module and a breathing circuit connected with the patient end; the ventilation device is used to output a first gas containing air and oxygen to the patient end through the breathing circuit; the nitric oxide output module is used to output a second gas containing nitric oxide to the patient end; a gas flow sensor is arranged at the gas outlet of the second gas; wherein, The gas flow sensor arranged at the gas outlet of the second gas is used to obtain the second gas flow rate corresponding to the second gas; The ventilation device is further used to determine the target gas flow rate corresponding to the patient end based on the target ventilation parameter set by the user; determine the target first gas flow rate corresponding to the first gas based on the second gas flow rate and the target gas flow rate; output the first gas at the target first gas flow rate, so that the gas provided to the patient end meets the requirements of the target ventilation parameter.

18. A ventilation device, characterized in that The ventilation device is in communication connection with a nitric oxide output module; the ventilation device comprises a breathing circuit connected with the patient end; the ventilation device is used to output a first gas containing air and oxygen to the patient end through the breathing circuit; the nitric oxide output module is used to output a second gas containing nitric oxide to the patient end; the second gas is connected between the first gas to be delivered and the patient end; a gas flow sensor is arranged at the gas outlet of the second gas; wherein, The nitric oxide output module is used to obtain the second gas flow rate corresponding to the second gas through the gas flow sensor arranged at the gas outlet of the second gas, and transmit it to the ventilation device; The ventilation device is further used to determine the target gas flow rate corresponding to the patient end based on the target ventilation parameter set by the user; determine the target first gas flow rate corresponding to the first gas based on the second gas flow rate and the target gas flow rate; output the first gas at the target first gas flow rate, so that the gas provided to the patient end meets the requirements of the target ventilation parameter.

19. A ventilation device, characterized in that The ventilation device comprises a nitric oxide output module and a breathing circuit connected with the patient end; the ventilation device is used to output a first gas containing air and oxygen to the patient end through the breathing circuit; the nitric oxide output module is used to output a second gas containing nitric oxide to the patient end; the second gas is connected between the first gas to be delivered and the patient end; wherein, The gas flow sensor arranged at the gas outlet of the second gas is used to obtain the second gas flow rate corresponding to the second gas; The gas flow sensor arranged at the gas outlet of the second gas is used to obtain the second gas flow rate corresponding to the second gas; The ventilation device is further configured to: determine a target carrier gas flow rate and a target oxygen flow rate corresponding to oxygen based on a target gas flow rate and a target oxygen concentration set by a user; determine a target air flow rate corresponding to air according to the target carrier gas flow rate and the second gas flow rate; and input air into the breathing circuit at the target air flow rate and input oxygen into the breathing circuit at the target oxygen flow rate, so that the oxygen concentration at the patient end meets the requirement of the target oxygen concentration.

20. A ventilation device, characterized in that The ventilation device is in communication with a nitric oxide output module; the ventilation device comprises a breathing circuit connected to the patient end; the ventilation device is configured to input air and oxygen into the breathing circuit respectively, and the air and oxygen are mixed in the breathing circuit to form a first gas output to the patient end; the nitric oxide output module is configured to output a second gas containing nitric oxide to the patient end; the second gas is connected between the first gas being delivered and the patient end; wherein, The nitric oxide output module is configured to acquire a second gas flow rate corresponding to the second gas through a gas flow sensor arranged at a gas outlet of the second gas, and transmit the second gas flow rate to the ventilation device; The ventilation device is further configured to: determine a target carrier gas flow rate and a target oxygen flow rate corresponding to oxygen based on a target gas flow rate and a target oxygen concentration set by a user; determine a target air flow rate corresponding to air according to the target carrier gas flow rate and the second gas flow rate; and input air into the breathing circuit at the target air flow rate and input oxygen into the breathing circuit at the target oxygen flow rate, so that the oxygen concentration at the patient end meets the requirement of the target oxygen concentration.

21. A nitric oxide output module, comprising: The nitric oxide output module is in communication with the ventilation device, and the ventilation device is configured to output a first gas containing air and oxygen to the patient end at a target first gas flow rate through a breathing circuit connected to the patient end; the nitric oxide output module is configured to output a second gas containing nitric oxide to the patient end at a target second gas flow rate; the second gas is connected between the first gas being delivered and the patient end; the nitric oxide output module is further configured to detect the concentration of nitric oxide in the gas at the patient end to determine the concentration of nitric oxide at the patient end; the nitric oxide output module is further configured to: adjust the target second gas flow rate and / or the concentration of nitric oxide in the second gas based on the concentration of nitric oxide at the patient end and a target concentration of nitric oxide at the patient end, so that the concentration of nitric oxide at the patient end meets the requirement of the target concentration of nitric oxide; and / or transmit the concentration of nitric oxide at the patient end to the ventilation device, so that the ventilation device adjusts the target first gas flow rate based on the concentration of nitric oxide at the patient end and the target concentration of nitric oxide at the patient end, so that the concentration of nitric oxide at the patient end meets the requirement of the target concentration of nitric oxide.

22. A ventilation device, characterized in that The ventilation device comprises: a nitric oxide output module; the ventilation device is used to output a first gas containing air and oxygen to a patient end at a target first gas flow rate through a breathing circuit connected with the patient end; the nitric oxide output module is used to output a second gas containing nitric oxide to the patient end; the second gas is connected between the first gas delivered and the patient end; the nitric oxide output module is also used to detect the concentration of nitric oxide in the gas of the patient end, and determine the concentration of nitric oxide of the patient end; the ventilation device is also used to: obtain the concentration of nitric oxide of the patient end; based on the concentration of nitric oxide of the patient end and a target concentration of nitric oxide, adjust the target first gas flow rate so that the concentration of nitric oxide of the patient end meets the requirement of the target concentration of nitric oxide.

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