Transdermal patch containing lidocaine as well as preparation method and application of transdermal patch

By adjusting the lidocaine content and using cross-linked acrylic pressure-sensitive adhesive and penetration enhancer, the preparation process was optimized, resolving the contradiction between drug permeation and adhesive application performance in existing lidocaine transdermal patches, and achieving a stable transdermal drug delivery system.

CN121818581APending Publication Date: 2026-04-10DEMOTECH INC
2 Cites 0 Cited by

Patent Information

Application Number
CN202610200314.9
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2023-12-28
Publication Date
2026-04-10

AI Technical Summary

Technical Problem

Existing lidocaine transdermal patches, while meeting the clinical treatment requirements for drug permeation, struggle to simultaneously possess good colloidal application performance and stability, especially prone to crystallization, cold flow, and skin irritation issues during long-term application.

Method used

Transdermal patches were prepared by adjusting the lidocaine content in the polymer matrix layer to 21% to 33%, combining cross-linked acrylic pressure-sensitive adhesive and penetration enhancer, optimizing viscosity and Tg value, avoiding the use of crystallization inhibitors, tackifiers and plasticizers, controlling the content of cross-linking agents, and drying in a ventilated environment at 50℃~60℃.

Benefits of technology

It achieves drug permeation levels sufficient for clinical treatment, possesses excellent colloidal patch performance and stability, reduces crystallization and cold flow phenomena, minimizes skin irritation, and is suitable for long-term use.

✦ Generated by Eureka AI based on patent content.
Patent Text Reader

Abstract

The invention discloses a transdermal patch containing lidocaine, the transdermal patch comprises a polymer matrix layer, the polymer matrix layer comprises active ingredients lidocaine, an acrylic acid pressure-sensitive adhesive and a penetration enhancer, the weight content of the lidocaine is 21-33%, the weight content of the acrylic acid pressure-sensitive adhesive is 45-75%, the weight content of the penetration enhancer is 1-10%, and the weight content of the penetration enhancer is 1-10%. The weight content of the penetration enhancer is 3%-25%. The transdermal patch disclosed by the invention is simple in prescription and process, good in drug permeability and colloid application performance and high in stability, can be continuously used for a long time without causing skin irritation, and is suitable for treating peripheral nerve related pains, especially patients requiring long-term administration such as post-herpes zoster neuralgia.
Need to check novelty before this filing date? Find Prior Art