Aqueous stable novaluron composition

Abstract

The present invention relates to a stable liquid agrochemical composition comprising novaluron and the use thereof.

Description

[0001] Throughout this application, different publications are referenced. The disclosures of these documents in their entireties are hereby incorporated by reference into this application in order to more fully describe the state of the art to which this application pertains. TECHNICAL FIELD

[0002] The present invention relates to a stable aqueous composition comprising fluroxamide, at least two wetting agents and at least two dispersants. BACKGROUND

[0003] Fluroxamide, i.e. (±)-1-[3-chloro-4-(1,1,2-trifluoro-2-trifluoromethoxyethoxy)phenyl]-3-(2,6- difluorobenzoyl)urea, is used as an insect growth regulator (IGR). The most commonly used formulations for solid water-insoluble pesticides are suspension concentrates, emulsifiable concentrates and emulsion in water formulations, which are liquid formulations and wherein the pesticide is dissolved in an organic carrier.

[0004] Fluroxamide is a solid at ambient temperature, has very low water solubility and very low wettability. Therefore, formulating high amounts of fluroxamide, especially in water-based compositions, is highly challenging.

[0005] WO 2022 / 264064 discloses water-dispersible solid compositions comprising fluroxamide and silicone-based surfactants. However, there is still a need for stable, high-load, easy-to-handle and efficient liquid compositions of fluroxamide. SUMMARY

[0006] The present invention provides a stable high-load agrochemical composition comprising: (a) an amount of fluroxamide; (b) a system of at least two wetting agents; and (c) a system of at least two dispersants.

[0007] The present invention further provides the use of at least two wetting agents and at least two dispersants for increasing the stability of a liquid composition comprising fluroxamide.

[0008] The present invention further provides the use of a composition as disclosed herein for treating a plant.

[0009] The present invention further provides a method of treating a plant using a composition as disclosed herein.

[0010] The present invention further provides a method for preparing a composition as disclosed herein. DETAILED DESCRIPTION

[0011] Definitions

[0012] Before the present subject matter is described, it is to be understood that unless otherwise indicated herein, the subject matter described herein is not limited to specific terms used herein unless otherwise indicated herein.

[0013] As used herein, the term "effective amount" means an amount of fluroxamide as described herein, which when ingested, contacted or sensed, is sufficient to achieve a good level of control, i.e., to control a harmful insect on a crop plant without causing any significant damage to the treated crop plant.

[0014] As used herein, "agriculturally acceptable additives" are compounds known and accepted in the art for use in forming compositions for agricultural or horticultural use.

[0015] As used herein, the term "plant" includes reference to the whole plant, plant organs (e.g., leaves, stems, twigs, roots, trunks, limbs, shoots, fruits, etc.), plant cells, a locus of a plant, or propagating material thereof.

[0016] As used herein, the term "plant" includes reference to a crop plant (including field crops (soybean, corn, wheat, rice, etc.), vegetable crops (potato, cabbage, etc.), and fruit trees (peach trees, etc.).

[0017] As used herein, the term "propagating material" is understood to mean all generative parts of the plant such as seeds and spores; vegetative structures such as bulbs, corms, tubers, rhizomes, roots stems, basal shoots, stolons, and buds.

[0018] As used herein, the term "locus" includes not only areas where insects can already be present, but also areas where insects have not yet appeared and areas under cultivation.

[0019] As used herein, the term "treated plant" is understood to mean controlling or protecting a plant from an insect attack or a disease caused by an unwanted insect or preventing an insect attack or a plant disease caused by an unwanted insect.

[0020] As described herein, the terms "wetter" and "wetting agent" are interchangeable.

[0021] As used herein, the term "ha" means hectare.

[0022] The terms "a" and "an" as used herein include both singular and plural unless otherwise specifically indicated. Thus, the terms "a" and "at least one" can be used interchangeably in the application.

[0023] Throughout this application, the description of different embodiments uses the term "comprising"; however, the skilled person will understand that in some specific instances the language "consisting essentially of" or "consisting of" can alternatively be used to describe the embodiments.

[0024] The term "about" as used herein specifically includes ± 10% of the specified value. In addition, the endpoints of all ranges directed to the same component or property are inclusive of the endpoint, are independently combinable, and include all intermediate points and ranges. It is to be understood that where a parameter range is provided, all integers within that range, and tenths thereof, are also provided by the application. For example, "10-50%" includes 10%, 10.1%, 10.2%, etc. up to 50%.

[0025] Formulating fluroxypyr in water, and in particular high load fluroxypyr, is challenging. Fluroxypyr has very low water solubility and very low wettability. Such formulations often face issues such as high viscosity, problems during the milling process, settling and instability, especially after storage (14 days at 54°C).

[0026] It was found that fluroxypyr can be formulated into stable liquid compositions comprising a system of at least two wetting agents and a system of at least two dispersants.

[0027] Composition:

[0028] According to one aspect, the present application provides a stable high load agrochemical composition comprising: (a) an amount of fluroxypyr; (b) a system of at least two wetting agents; and (c) a system of at least two dispersants.

[0029] According to some embodiments, the wetting agent is selected from the group consisting of silicone-based surfactants and alkyl polyoxyalkylene glycol ether phosphates.

[0030] According to some embodiments, the wetting agent system is a combination of at least one silicone-based surfactant and at least one alkyl polyoxyalkylene glycol ether phosphate.

[0031] The wetting agent system can optionally further comprise an alcohol ethoxylate. In some embodiments, the alcohol ethoxylate is a secondary alcohol ethoxylate.

[0032] In some embodiments, the silicone-based surfactant is an organically modified trisiloxane.

[0033] In some embodiments, the silicone-based surfactant is selected from Silwet. ® L77, Silwet 806, BREAK-THRU ® S 240, BREAK-THRU ® S 233 / Compound 3-(8-methoxyoctoxy)propyl-methyl-bis(trimethylsiloxy)silane and compounds having the following structures: Where n = 1-4, y = 3-10, z = 0-5, and R is an alkyl group or H or OH having 1-4 carbon atoms.

[0034] In some specific embodiments, the silicone-based surfactant is BreakThru S-240.

[0035] In some other embodiments, the alkyl polyalkylene glycol ether phosphate acid form is selected from Hostaphart. ® 1306 (alkyl polyethylene glycol ether phosphate mono / diester (50 / 50), acid form), Hostaphat ® CC 100 (Cetyl phosphate, acid form, mono / diester approximately 98%), SERVOXYL VPDZ 3 / 100 (Trinyl polyethylene glycol ether (3EO) phosphate), PROTE-PONP-TD-06-Z (Alkyl ether phosphate), LUBRHOPHOS LP 700 (Phosphate with aromatic base), RHODAFAC BG 510 (Phosphate with aliphatic base), DERMALIX C (Alkyl phosphate in aqueous / organic media), SANDOCLEANSKBB (Alkyl phosphate), PROTE-PON TD-09-K30 (Alkyl ether potassium phosphate), PAE 147 (Phosphated alcohol ethoxylate), LIBRAPHOS AD (Sodium salt of Libraphos EP 120), NIKKOL DDP-2 (DiPOE(2) alkyl ether phosphate; free acid form), MARLOPHOR NP7-ACID (Nonylphenol polyethylene glycol ether phosphate), MARLOWET 5301 (coconut oil polyethylene glycol ether phosphate), ATLAS G-2203 (potassium salt of phosphate), FOSFODET 1214 N / 16 (ethoxylated fatty alcohol phosphate).

[0036] In some embodiments, the alkyl polyalkylene glycol ether phosphate form is Hostaphart. ® 1306.

[0037] In some other embodiments, the alcohol ethoxylate is selected from Tergitol 15-S-7, Tergitol 15-S-9, Tergitol 15-S-12 and compounds having the following structures: , where m + n = 15 and x is the number of repeating ethoxylate (EO) units.

[0038] In some embodiments, the alcohol ethoxylate is Tergitol 15-S-7.

[0039] In some embodiments, the dispersant is selected from polyelectrolyte comb copolymers, EO-PO copolymers, polymethyl methacrylate-polyethylene glycol graft copolymers, tristyrylphenol ethoxylate in phosphate form, and polyoxyethylene sorbitol ester.

[0040] In some other embodiments, the dispersant system comprises a combination of a polyelectrolyte comb copolymer surfactant and at least one other dispersant.

[0041] In some embodiments, at least one other dispersant is selected from polyelectrolyte comb copolymers, EO-PO copolymers, polymethyl methacrylate-polyethylene glycol graft copolymers, tristyrylphenol ethoxylate in phosphate form, and polyoxyethylene sorbitol ester.

[0042] In some embodiments, the polyelectrolyte comb copolymer is the polyelectrolyte disclosed in application publication WO 2017 / 098325, the entire contents of which are incorporated herein by reference.

[0043] In some embodiments, the polyelectrolyte comb copolymer comprises a hydrophobic anchoring portion and at least one hydrophilic charged stabilizing portion.

[0044] In some embodiments, the hydrophilic charged stabilizing portion comprises at least one charged monomer, preferably an anionic monomer having a sulfonate group.

[0045] In some embodiments, the molar ratio of the hydrophobic anchoring portion to the hydrophilic charged stabilizing portion is 1:2-4.

[0046] In some embodiments, the weight ratio of the hydrophobic anchoring portion to the hydrophilic charged stabilizing portion is less than 0.6.

[0047] In some embodiments, at least 60% by weight of the hydrophilic charged stabilizing portion is a charged monomer.

[0048] In some embodiments, the polyelectrolyte comb copolymer is PolyAgroA.

[0049] PolyAgro A is a block copolymer formulation that forms a polyelectrolyte layer. The composition of PolyAgro A is shown in the table below:

[0050]

[0051] PolyAgro A is a diblock copolymer with a total weight of 17,000 g / mol, composed of hydrophobic blocks (anchoring blocks: ANCHOR) and hydrophilic blocks (stabilizing blocks: STAB). The stabilized hydrophilic blocks are made from sodium 2-acryloylamino-2-methylpropane-1-sulfonate (AMPS) monomer, accounting for 77% of the total monomers in the polymer. The remaining 23% of the monomers are anchoring hydrophobic blocks made from ethyl acrylate monomers. The total number of monomers in the polymer (degree of polymerization, DPn) is 85.

[0052] Such polymers can be obtained from Rhodia Operations (a Paris-based company and a member of the Solvay Group).

[0053] Such polymers can also be prepared as described in application publication number WO 2017 / 098325. WO 2017 / 098325 was filed by Solvay Group members Rhodia Operations and Adama Makhteshi Ltd.

[0054] As described in WO 2017 / 098325, the block copolymer forming the polyelectrolyte layer used in the formulations of the present invention can be prepared according to the following procedure.

[0055] a) Macro CTA

[0056] 11.26 g of O-ethyl-S-(1-methoxycarbonylethyl) xanthate (CH3CH(CO2CH3))S(C=S)OEt), 264.08 g of ethanol, 356.32 g of deionized water, 1400 g of AMPS(Na) solution (50% active), and 1.52 g of 4,4'-azobis(4-cyanopentanoic acid) were added to a 2 L double-jacketed reactor equipped with a mechanical stirrer and a reflux condenser. The reactor contents were heated to 70°C with stirring and nitrogen. The reaction mixture was then aged at 70°C for one hour, followed by cooling to ambient temperature and discharge. The measured solids content was 37.6% (115°C, 60 min). GPC Mals: Mn = 16300 Mw = 2600 IP = 1.6.

[0057] b) Chain extension

[0058] 2127 g of macroCTA solution (see a) and 330 g of deionized water were added to a 5 L double-jacketed reactor equipped with a mechanical stirrer and a reflux condenser. The reactor contents were heated to 70°C with stirring and a nitrogen flow. Once 70°C was reached, 106.67 g of ethyl acrylate (EA) was added over 2 hours, followed by the addition of 37.37 g of 10 wt% 4,4'-azobis(4-cyanopentanoic acid) solution over 2 hours. After the initiator solution was introduced, the reaction solution was further aged for one hour. Subsequently, 44.85 g of 10 wt% 4,4'-azobis(4-cyanopentanoic acid) solution was added in a single batch, and the mixture was aged again at 70°C for one hour, then cooled to ambient temperature and discharged. The measured solids content was 40.0% (115°C, 60 minutes).

[0059] Ethanol was removed from the polymer solution using a rotary evaporator. Water was then added back to obtain a polymer solution with a final solids content of 40.4%.

[0060] 2600 g of polymer solution was placed in a 5 L double-jacketed reactor equipped with a mechanical stirrer and a reflux condenser. The pH of the solution was increased to 8.5 using a 50% NaOH solution. The mixture was heated to 70°C with stirring, followed by the addition of 48.4 g of a 30% hydrogen peroxide solution over 1 hour. At the end of the addition, the solution was aged for another 3 hours, then cooled and discharged. Residual monomer was measured by HPLC and GC (AMPS = 22 ppm, EA = 2 ppm). The measured solids content was 37.5%.

[0061] In some other embodiments, the EO-PO copolymer is selected from Ethylan NS 500 (polyalkoxylated butyl ether), Antarox B / 848 (ethylene oxide, methyl-, and ethylene oxide polymer), Ultraic 5000 HM (ethoxylated and propoxylated alcohols), Toximul 8350 (polyethylene glycol-polypropylene glycol monobutyl ether), Tergitol XD (ethylene oxide / propylene oxide block copolymer), Atlas G-5000-SO-(CQ) (ethylene oxide, 2-methyl-, and ethylene oxide polymer, monobutyl ether), Atlas G-5002L-LQ-(CQ) (ethylene oxide, monobutyl ether), SYNERGEN 848 (block polyoxyalkylene oxide), Ethylan 992, and Ultraric 5000 HM (EU source) (polyethylene glycol-polypropylene glycol monobutyl ether).

[0062] In some other embodiments, the polymethyl methacrylate-polyethylene glycol graft copolymer is selected from Atlox 4913, STEP-FLOW 3000, STEP-FLOW 4000 and Tersperse 2500.

[0063] In some embodiments, the tristyrylphenol ethoxylate phosphate form is selected from Soprophor 3D33, Soprophor FL, Surfom 1322 SC, Agnique PE TSP 16T and Dispersogen TP 160T.

[0064] In some embodiments, polyoxyethylene sorbitol ester is selected from Tween 20, Hostacerin L 20, Hostacerin L 20 SG Vita, Alkamuls T 20, Emulsogen 4156, and Alkest TW 20.

[0065] In some embodiments, the dispersant and the wetting agent are the same.

[0066] In some embodiments, the dispersant and the wetting agent are different.

[0067] In some embodiments, the composition is highly loaded.

[0068] In some embodiments, high loading means that the composition contains an amount of active ingredient greater than 30% w / w based on the total weight of the composition.

[0069] In some embodiments, the amount of fluorourea is 5-60% w / w based on the total weight of the composition. In some embodiments, the amount of fluorourea is 10-60% w / w based on the total weight of the composition. In some embodiments, the amount of fluorourea is 15-60% w / w based on the total weight of the composition. In some embodiments, the amount of fluorourea is 20-60% w / w based on the total weight of the composition. In some embodiments, the amount of fluorourea is 25-60% w / w based on the total weight of the composition. In some embodiments, the amount of fluorourea is 30-60% w / w based on the total weight of the composition. In some embodiments, the amount of fluorourea is 35-60% w / w based on the total weight of the composition. In some embodiments, the amount of fluorourea is 35-55% w / w based on the total weight of the composition. In some embodiments, the amount of fluorourea is 35-50% w / w based on the total weight of the composition. In some embodiments, the amount of fluorourea is 40-60% w / w based on the total weight of the composition. In some embodiments, the amount of fluorourea is 40-55% w / w based on the total weight of the composition. In some embodiments, the amount of fluorourea is 40-50% w / w based on the total weight of the composition. In some embodiments, the amount of fluorourea is 40% w / w based on the total weight of the composition. In some embodiments, the amount of fluorourea is 50% w / w based on the total weight of the composition. In some embodiments, the amount of fluorourea is 55% w / w based on the total weight of the composition. In some embodiments, the amount of fluorourea is 60% w / w based on the total weight of the composition. This amount can be any intermediate value or range selected from the specified amounts.

[0070] In some embodiments, the amount of fluorourea is between about 350 g / L and about 750 g / L based on the total weight of the composition. In some embodiments, the amount of fluorourea is between about 400 g / L and about 800 g / L based on the total weight of the composition. In some embodiments, the amount of fluorourea is between about 400 g / L and about 700 g / L based on the total weight of the composition. In some embodiments, the amount of fluorourea is between about 400 g / L and about 600 g / L based on the total weight of the composition. The amount of fluorourea can be an intermediate range selected from any of the ratios specified above. In some embodiments, the amount of fluorourea is about 780 g / L based on the total weight of the composition. In some embodiments, the amount of fluorourea is about 750 g / L based on the total weight of the composition. In some embodiments, the amount of fluorourea is about 700 g / L based on the total weight of the composition. In some embodiments, the amount of fluorourea is about 650 g / L based on the total weight of the composition. In some embodiments, the amount of fluorourea is about 600 g / L based on the total weight of the composition. In some embodiments, the amount of fluorourea is about 550 g / L based on the total weight of the composition. In some embodiments, the amount of fluorourea is about 500 g / L based on the total weight of the composition. In some embodiments, the amount of fluorourea is about 450 g / L based on the total weight of the composition. In some embodiments, the amount of fluorourea is about 400 g / L based on the total weight of the composition. In some embodiments, the amount of fluorourea is about 350 g / L based on the total weight of the composition. This amount can be any intermediate value or intermediate range selected from the specified amount.

[0071] In some embodiments, the total amount of the wetting agent system is 1.5-10% w / w based on the total weight of the composition. In some embodiments, the total amount of the wetting agent system is 1.5-7.5% w / w based on the total weight of the composition. In some embodiments, the total amount of the wetting agent system is 1.5-6% w / w based on the total weight of the composition. In some embodiments, the total amount of the wetting agent system is about 4.5% w / w based on the total weight of the composition. In some embodiments, the total amount of the wetting agent system is about 7.5% w / w based on the total weight of the composition. This amount can be any intermediate value or range selected from the specified amounts.

[0072] In some embodiments, the total amount of the dispersant system is 2-12% w / w based on the total weight of the composition. In some embodiments, the total amount of the dispersant system is 2-10% w / w based on the total weight of the composition. In some embodiments, the total amount of the dispersant system is 2-8% w / w based on the total weight of the composition. In some embodiments, the total amount of the dispersant system is about 5% w / w based on the total weight of the composition. This amount can be any intermediate value or range selected from the specified amounts.

[0073] In some embodiments, the amount of alkyl polyethylene glycol ether phosphate mono / diester (50 / 50) acid is 1-4% w / w based on the total weight of the composition. This amount can be any intermediate value or range selected from the specified amount.

[0074] In some embodiments, the amount of polyether trisiloxane is 0.5-2% w / w based on the total weight of the composition. This amount can be any intermediate value or range selected from the specified amount.

[0075] In some embodiments, the amount of EO-PO copolymer is 1-4% w / w based on the total weight of the composition. This amount can be any intermediate value or range selected from the specified amount.

[0076] In some embodiments, the amount of polymethyl methacrylate-polyethylene glycol graft copolymer is 1-4% w / w based on the total weight of the composition. This amount can be any intermediate value or range selected from the specified amount.

[0077] In some embodiments, the amount of the polyelectrolyte comb copolymer is 1-4% w / w based on the total weight of the composition. This amount can be any intermediate value or range selected from the specified amount.

[0078] In some embodiments, the amount of tristyrylphenol ethoxylate in phosphate form is 1-4% w / w based on the total weight of the composition. This amount can be any intermediate value or range selected from the specified amount.

[0079] In some embodiments, the amount of polyoxyethylene sorbitol ester is 1-4% w / w based on the total weight of the composition. This amount can be any intermediate value or range selected from the specified amount.

[0080] In some embodiments, the weight ratio of the wetting agent system to fluorourea in the composition is 1:40 to 1.6:1. In some embodiments, the weight ratio of the wetting agent system to fluorourea in the composition is 1:40 to 1.5:1. In some embodiments, the weight ratio of the wetting agent system to fluorourea in the composition is 1:40 to 1.2:1. In some embodiments, the weight ratio of the wetting agent system to fluorourea in the composition is 1:40 to 1:1.6. In some embodiments, the weight ratio of the wetting agent system to fluorourea in the composition is 1:40 to 1:2.5. In some embodiments, the weight ratio of the wetting agent system to fluorourea in the composition is 1:40 to 1:3.33. In some embodiments, the weight ratio of the wetting agent system to fluorourea in the composition is 1:40 to 1:4.2. In some embodiments, the weight ratio of the wetting agent system to fluorourea in the composition is 1:40 to 1:5. In some embodiments, the weight ratio of the wetting agent system to fluorourea in the composition is 1:40 to 1:6. In some embodiments, the weight ratio of the wetting agent system to fluorourea in the composition is 1:36 to 1:1.6. In some embodiments, the weight ratio of the wetting agent system to fluorourea in the composition is 1:33 to 1:1.6. In some embodiments, the weight ratio of the wetting agent system to fluorourea in the composition is about 1:9. In some embodiments, the weight ratio of the wetting agent system to fluorourea in the composition is about 1:12. In some embodiments, the weight ratio of the wetting agent system to fluorourea in the composition is about 1:13. The weight ratio can be any intermediate value or range selected from the specified ratio.

[0081] In some embodiments, the weight ratio of the wetting agents in the composition is from 8:1 to 1:2. The weight ratio can be any intermediate range selected from the specified ratio.

[0082] In some embodiments, the weight ratio of the dispersants in the composition is from 4:1 to 1:4. The weight ratio can be any intermediate range selected from the specified ratio.

[0083] In some embodiments, the weight ratio of alkyl polyethylene glycol ether phosphate mono / diester (50 / 50) acid to fluorourea in the composition is 1:60 to 1:1.25. In some embodiments, the weight ratio of alkyl polyethylene glycol ether phosphate mono / diester (50 / 50) acid to fluorourea in the composition is 1:60 to 1:2.5. In some embodiments, the weight ratio of alkyl polyethylene glycol ether phosphate mono / diester (50 / 50) acid to fluorourea in the composition is 1:60 to 1:3.75. In some embodiments, the weight ratio of alkyl polyethylene glycol ether phosphate mono / diester (50 / 50) acid to fluorourea in the composition is 1:60 to 1:5. In some embodiments, the weight ratio of alkyl polyethylene glycol ether phosphate mono / diester (50 / 50) acid to fluorourea in the composition is 1:60 to 1:6.25. In some embodiments, the weight ratio of alkyl polyethylene glycol ether phosphate mono / diester (50 / 50) acid to fluorourea in the composition is 1:60 to 1:7.5. In some embodiments, the weight ratio of alkyl polyethylene glycol ether phosphate mono / diester (50 / 50) acid to fluorourea in the composition is 1:60 to 1:8.75. In some embodiments, the weight ratio of alkyl polyethylene glycol ether phosphate mono / diester (50 / 50) acid to fluorourea in the composition is 1:55 to 1:8.75. In some embodiments, the weight ratio of alkyl polyethylene glycol ether phosphate mono / diester (50 / 50) acid to fluorourea in the composition is 1:50 to 1:8.75. In some embodiments, the weight ratio of alkyl polyethylene glycol ether phosphate mono / diester (50 / 50) acid to fluorourea in the composition is about 1:30. In some embodiments, the weight ratio of the alkyl polyethylene glycol ether phosphate mono / diester (50 / 50) acid form to the fluorourea in the composition is about 1:26. In some embodiments, the weight ratio of the alkyl polyethylene glycol ether phosphate mono / diester (50 / 50) acid form to the fluorourea in the composition is about 1:20. The weight ratio can be any intermediate value or intermediate range selected from the specified ratio.

[0084] In some embodiments, the weight ratio of polyether trisiloxane to fluorourea in the composition is 1:120 to 1:2.5. In some embodiments, the weight ratio of polyether trisiloxane to fluorourea in the composition is 1:120 to 1:5. In some embodiments, the weight ratio of polyether trisiloxane to fluorourea in the composition is 1:120 to 1:7.5. In some embodiments, the weight ratio of polyether trisiloxane to fluorourea in the composition is 1:120 to 1:10. In some embodiments, the weight ratio of polyether trisiloxane to fluorourea in the composition is 1:120 to 1:12.5. In some embodiments, the weight ratio of polyether trisiloxane to fluorourea in the composition is 1:120 to 1:15. In some embodiments, the weight ratio of polyether trisiloxane to fluorourea in the composition is 1:120 to 1:17.5. In some embodiments, the weight ratio of polyether trisiloxane to fluorourea in the composition is from 1:110 to 1:17.5. In some embodiments, the weight ratio of polyether trisiloxane to fluorourea in the composition is from 1:100 to 1:17.5. In some embodiments, the weight ratio of polyether trisiloxane to fluorourea in the composition is about 1:60. In some embodiments, the weight ratio of polyether trisiloxane to fluorourea in the composition is about 1:53. In some embodiments, the weight ratio of polyether trisiloxane to fluorourea in the composition is about 1:40.

[0085] In some embodiments, the weight ratio between the alkyl polyethylene glycol ether phosphate mono / diester (50 / 50) acid form and the polyether trisiloxane in the composition is from 8:1 to 1:2. The weight ratio can be any intermediate value or range selected from the specified ratio.

[0086] In some embodiments, when the wetting agent system further comprises an alcohol ethoxylate, the amount of the alcohol ethoxylate is 1-4% w / w based on the total weight of the composition. This amount can be any intermediate value or range selected from the specified amounts.

[0087] In some embodiments, the weight ratio of the dispersant system to fluorourea in the composition is from 1:30 to 1.6:1. The weight ratio can be an intermediate range selected from any of the specified ratios. In some embodiments, the weight ratio of the dispersant system to fluorourea in the composition is from 1:30 to 1:1.25. In some embodiments, the weight ratio of the dispersant system to fluorourea in the composition is from 1:30 to 1:1.875. In some embodiments, the weight ratio of the dispersant system to fluorourea in the composition is from 1:30 to 1:2.5. In some embodiments, the weight ratio of the dispersant system to fluorourea in the composition is from 1:30 to 1:3.125. In some embodiments, the weight ratio of the dispersant system to fluorourea in the composition is from 1:30 to 1:3.75. In some embodiments, the weight ratio of the dispersant system to fluorourea in the composition is from 1:30 to 1:4.375. In some embodiments, the weight ratio of the dispersant system to fluorourea in the composition is from 1:27.5 to 1:4.375. In some embodiments, the weight ratio of the dispersant system to fluorourea in the composition is from 1:25 to 1:4.375. In some embodiments, the weight ratio of the dispersant system to fluorourea in the composition is 1:8. In some embodiments, the weight ratio of the dispersant system to fluorourea in the composition is 1:10. In some embodiments, the weight ratio of the dispersant system to fluorourea in the composition is 1:12. The weight ratio can be any intermediate value or range selected from the specified ratio.

[0088] In some embodiments, the weight ratio of the dispersants in the composition is from 4:1 to 1:4.

[0089] In some embodiments, the weight ratio between the polyelectrolyte comb copolymer and the additional dispersant in the composition is from 4:1 to 1:4.

[0090] In some embodiments, the weight ratio of the polyelectrolyte comb copolymer to fluorourea in the composition is 1:60 to 1:1.25. In some embodiments, the weight ratio of the polyelectrolyte comb copolymer to fluorourea in the composition is 1:60 to 1:2.5. In some embodiments, the weight ratio of the polyelectrolyte comb copolymer to fluorourea in the composition is 1:60 to 1:3.75. In some embodiments, the weight ratio of the polyelectrolyte comb copolymer to fluorourea in the composition is 1:60 to 1:5. In some embodiments, the weight ratio of the polyelectrolyte comb copolymer to fluorourea in the composition is 1:60 to 1:6.25. In some embodiments, the weight ratio of the polyelectrolyte comb copolymer to fluorourea in the composition is 1:60 to 1:7.5. In some embodiments, the weight ratio of the polyelectrolyte comb copolymer to fluorourea in the composition is 1:60 to 1:8.75. In some embodiments, the weight ratio of the polyelectrolyte comb copolymer to fluorourea in the composition is from 1:55 to 1:8.75. In some embodiments, the weight ratio of the polyelectrolyte comb copolymer to fluorourea in the composition is from 1:50 to 1:8.75. In some embodiments, the weight ratio of the polyelectrolyte comb copolymer to fluorourea in the composition is about 1:30. In some embodiments, the weight ratio of the polyelectrolyte comb copolymer to fluorourea in the composition is about 1:26. In some embodiments, the weight ratio of the polyelectrolyte comb copolymer to fluorourea in the composition is about 1:20. The weight ratio can be any intermediate value or intermediate range selected from the specified ratios. The weight ratio can be an intermediate range selected from any of the specified ratios.

[0091] In some embodiments, the weight ratio of the additional dispersant to fluorourea in the composition is 1:60 to 1:1.25. In some embodiments, the weight ratio of the additional dispersant to fluorourea in the composition is 1:60 to 1:2.5. In some embodiments, the weight ratio of the additional dispersant to fluorourea in the composition is 1:60 to 1:3.75. In some embodiments, the weight ratio of the additional dispersant to fluorourea in the composition is 1:60 to 1:5. In some embodiments, the weight ratio of the additional dispersant to fluorourea in the composition is 1:60 to 1:6.25. In some embodiments, the weight ratio of the additional dispersant to fluorourea in the composition is 1:60 to 1:7.5. In some embodiments, the weight ratio of the additional dispersant to fluorourea in the composition is 1:60 to 1:8.75. In some embodiments, the weight ratio of the additional dispersant to fluorourea in the composition is from 1:55 to 1:8.75. In some embodiments, the weight ratio of the additional dispersant to fluorourea in the composition is from 1:50 to 1:8.75. In some embodiments, the weight ratio of the additional dispersant to fluorourea in the composition is about 1:30. In some embodiments, the weight ratio of the additional dispersant to fluorourea in the composition is about 1:26. In some embodiments, the weight ratio of the additional dispersant to fluorourea in the composition is about 1:20. In some embodiments, the weight ratio of the additional dispersant to fluorourea in the composition is about 1:16. In some embodiments, the weight ratio of the additional dispersant to fluorourea in the composition is about 1:13. The weight ratio can be any intermediate value or range selected from the specified ratio.

[0092] In some embodiments, the composition is a suspension concentrate (SC). In some embodiments, the composition is an aqueous suspension. In some embodiments, the composition is a suspension emulsion (SE). In some embodiments, fluorourea is dispersed in an aqueous carrier. In some embodiments, fluorourea is partially dispersed in an aqueous carrier and partially dissolved in an organic carrier.

[0093] In some embodiments, the composition is a highly loaded SC composition.

[0094] In some embodiments, the composition is a highly loaded SE composition.

[0095] In some embodiments, the density of the SC composition is between 1 and 1.5 g / ml. The density may be an intermediate range selected from the specified range.

[0096] In some embodiments, the density of the SE composition is between 1 and 1.5 g / ml. The density may be an intermediate range selected from the specified range.

[0097] In some embodiments, the density of the SC composition is about 1.3 g / ml.

[0098] In some embodiments, the density of the SE composition is about 1.3 g / ml.

[0099] In some embodiments, the density of the SC composition is about 1.2 g / ml.

[0100] In some embodiments, the density of the SE composition is about 1.2 g / ml.

[0101] In some embodiments, the composition further comprises at least one agriculturally acceptable additive. Agriculturally acceptable additives include, but are not limited to, one or more carriers, one or more defoamers, one or more antifreeze agents, one or more stabilizers, one or more preservatives, one or more thickeners, and any combination thereof.

[0102] In some embodiments, the composition further comprises one or more adjuvants. In some embodiments, the adjuvant is a penetrant. In some embodiments, the adjuvant enhances the penetration of the active ingredient. In some embodiments, the adjuvant is a spreader. In some embodiments, the adjuvant improves the dispersion of the active ingredient on the leaf.

[0103] In some embodiments, agriculturally acceptable additives are compounds known in the art and accepted for forming liquid compositions for agricultural or horticultural use.

[0104] In some embodiments, the carrier is water.

[0105] In some embodiments, one or more defoamers are selected from Silcolapse 432 and SAG 1572.

[0106] In some embodiments, one or more antifreeze agents are selected from propylene glycol and glycerin.

[0107] In some embodiments, one or more stabilizers are magnesium aluminum silicate (montmorillonite clay) selected from Van Gel B.

[0108] In some embodiments, one or more preservatives are selected from Proxel GXL, Nipacide BIT AS 20, Amebact B 20, Biotrend CMT1.5, Rocima BT 25 microbial agent, and Wancide 520XL.

[0109] In some embodiments, one or more thickeners are selected from one or more polysaccharides: xanthan gum, Kelzan, Kelzan Advanced Performance, AG RH 23, Kelzan AP-AS, Kelzan HP, Rheozan, Rhodopol 23, Rhodopol 50 MC, Rhodopol MD 50, Rhodopol G, Rhodicare D, XCDBiopolymer, AG-RHO POL 23 / W.

[0110] In some embodiments, one or more thickeners are carboxymethyl cellulose, Cabosil, Bentone MA, or Bentone LT.

[0111] In some embodiments, one or more adjuvants are selected from Silwet. ® L77, Silwet 806, BREAK-THRU ® S 240, BREAK-THRU ® S 233 is a silicone-based surfactant.

[0112] In some embodiments, one or more adjuvants are Alkamuls AP, Synergen SOC, soybean methyl oleate, or Steposol ME.

[0113] In some embodiments, the amount of additive is 8-15% w / w based on the total weight of the composition.

[0114] In some embodiments, the amount of the adjuvant is 4-20% w / w based on the total weight of the composition. In some embodiments, the amount of the adjuvant is about 10% w / w based on the total weight of the composition. In some embodiments, the amount of the adjuvant is about 5% w / w based on the total weight of the composition.

[0115] In some embodiments, the present invention provides a suspension concentrate composition comprising:

[0116] a) Based on approximately 35-60% w / w of fluorouracil by weight of the total composition,

[0117] b) A system of at least two wetting agents in an amount of about 1.5-6% w / w of the total weight of the composition; and

[0118] c) A system of at least two dispersants in an amount of about 2-8% w / w of the total weight of the composition.

[0119] In some embodiments, the present invention provides a suspension concentrate composition comprising:

[0120] a) Based on a total weight of approximately 35-50% w / w of fluorourea in the composition,

[0121] b) A system of at least two wetting agents in an amount of about 1.5-6% w / w of the total weight of the composition;

[0122] c) A system of at least two dispersants in an amount of about 2-8% w / w of the total weight of the composition; and

[0123] d) An amount of adjuvants based on approximately 4-20% w / w of the total weight of the composition.

[0124] In some embodiments, the present invention provides a water-dispersible composition comprising:

[0125] a) Based on approximately 58% w / w of the total weight of the composition, fluorouracil,

[0126] b) Based on approximately 1.5% w / w of Tergitol 15-S-7 by total weight of the composition,

[0127] c) Hostaphat at approximately 2% w / w of the total weight of the composition. ® 1306,

[0128] d) Based on approximately 1% w / w of the total weight of the composition, BreakThru S-240,

[0129] e) Based on 3% w / w of the total weight of the composition, and

[0130] f) PolyAgroA in an amount of approximately 2% w / w based on the total weight of the composition.

[0131] In some embodiments, the suspension concentrate is physically stable.

[0132] In some embodiments, the physical stability of a suspension refers to the state when the fluorourea particles are dispersed and / or dissolved and do not float on the water surface.

[0133] In some embodiments, physical stability is evaluated after storage at 54°C for 14 days.

[0134] In some embodiments, the viscosity of the composition is less than 3000 cps. In some embodiments, the viscosity of the composition is less than 2500 cps. In some embodiments, the viscosity of the composition is less than 2000 cps. In some embodiments, the viscosity of the composition is less than 1500 cps. In some embodiments, the viscosity of the composition is less than 1000 cps. In some embodiments, the viscosity of the composition is less than 800 cps. In some embodiments, the viscosity of the composition is less than 700 cps. In some embodiments, the viscosity of the composition is less than 600 cps. In some embodiments, the viscosity of the composition is less than 500 cps. Viscosity can be an intermediate range selected from any specified value.

[0135] In some embodiments, one or more adjuvants are added to the SC composition “as is”, and the amount of one or more adjuvants is 1-20% w / w. In some embodiments, the amount of adjuvant is 5%-10% w / w based on the total weight of the composition.

[0136] In some embodiments, the adjuvant is formulated separately as an emulsion concentrate (EC).

[0137] In some embodiments, the SC composition comprises an auxiliary EC composition.

[0138] In some embodiments, the adjuvant is dissolved in an organic solvent.

[0139] In some embodiments, the organic solvent is an oil.

[0140] In some embodiments, the amount of the adjuvant is 30-50% w / w based on the total weight of the EC composition containing the adjuvant.

[0141] In some embodiments, the adjuvant EC formulation further comprises an emulsifier.

[0142] In some embodiments, the emulsifier is selected from benzenesulfonic acid, mono-C11-13-branched alkyl derivatives, and NINATE. ® Calcium salts of 401-ND.

[0143] In some embodiments, the emulsifier is sodium dioctyl sulfosuccinate selected from Emcol 4500, Lankropol KO2, Geropon CYA / 75, and DOSS 75E.

[0144] In some embodiments, the auxiliary EC formulation comprises oil.

[0145] In some embodiments, the oil is soybean oil selected from soybean oil fatty acid methyl esters and Steposol ME.

[0146] In some embodiments, the present invention provides an SE composition.

[0147] In some embodiments, the SE composition is a mixture of the SC fluorourea composition and the EC fluorourea composition. In some embodiments, the fluorourea is partially dispersed in water and partially dissolved in the oil phase.

[0148] In some embodiments, the SE composition is a mixture of the SC fluorourea composition and the EC adjuvant mixture. In some embodiments, the fluorourea is partially dispersed in water and partially dissolved in the EC adjuvant mixture.

[0149] In some embodiments, the amount of fluorourea dispersed in water in the SE formulation is between 25% and 60% by weight of the composition.

[0150] In some embodiments, the amount of fluorourea dissolved in the EC mixture in the SE formulation is between 1% and 10% by weight of the composition.

[0151] In some embodiments, the present invention provides an SE composition comprising:

[0152] a) Based on a total weight of approximately 35-50% w / w of fluorourea in the composition,

[0153] b) A system of at least two wetting agents in an amount of about 1.5-6% w / w of the total weight of the composition.

[0154] c) At least two dispersants in amounts of about 2-8% w / w of the total weight of the composition, and

[0155] d) An amount of adjuvants of approximately 4-7% w / w based on the total weight of the composition.

[0156] In some embodiments, the present invention provides an SE composition comprising:

[0157] a) Based on approximately 35% w / w of the total weight of the composition, fluorouracil.

[0158] b) A system of at least two wetting agents in an amount of about 1.4% w / w of the total weight of the composition;

[0159] c) A system of at least two dispersants in an amount of about 5% w / w of the total weight of the composition; and

[0160] d) An amount of adjuvants based on approximately 4% w / w of the total weight of the composition.

[0161] Use of stabilizing system:

[0162] In another aspect, the present invention provides the use of at least two wetting agents and at least two dispersants for increasing the stability of liquid compositions containing fluorourea.

[0163] According to some embodiments, the wetting agent is selected from silicone-based surfactants and alkyl polyalkylene glycol ether phosphate acids.

[0164] According to some embodiments, the wetting agent system is a combination of at least one silicone-based surfactant and at least one alkyl polyalkylene glycol ether phosphate acid.

[0165] The wetting agent system may optionally further comprise an alcohol ethoxylate. In some embodiments, the alcohol ethoxylate is a secondary alcohol ethoxylate.

[0166] In some embodiments, the silicone-based surfactant is an organically modified trisiloxane.

[0167] In some embodiments, the silicone-based surfactant is selected from Silwet. ® L77, Silwet 806, BREAK-THRU ® S 240, BREAK-THRU ® S 233 / Compound 3-(8-methoxyoctoxy)propyl-methyl-bis(trimethylsiloxy)silane and compounds having the following structures: Where n = 1-4, y = 3-10, z = 0-5, and R is an alkyl group or H or OH having 1-4 carbon atoms.

[0168] In some specific embodiments, the silicone-based surfactant is BreakThru S-240.

[0169] In some other embodiments, the alkyl polyalkylene glycol ether phosphate acid form is selected from Hostaphart. ® 1306 (alkyl polyethylene glycol ether phosphate mono / diester (50 / 50), acid form), Hostaphat ®CC 100 (Cetyl phosphate, acid form, mono / diester approximately 98%), SERVOXYL VPDZ 3 / 100 (Trinyl polyethylene glycol ether (3EO) phosphate), PROTE-PONP-TD-06-Z (Alkyl ether phosphate), LUBRHOPHOS LP 700 (Phosphate with aromatic base), RHODAFAC BG 510 (Phosphate with aliphatic base), DERMALIX C (Alkyl phosphate in aqueous / organic media), SANDOCLEANSKBB (Alkyl phosphate), PROTE-PON TD-09-K30 (Alkyl ether potassium phosphate), PAE 147 (Phosphated alcohol ethoxylate), LIBRAPHOS AD (Sodium salt of Libraphos EP 120), NIKKOL DDP-2 (DiPOE(2) alkyl ether phosphate; free acid form), MARLOPHOR NP7-ACID (Nonylphenol polyethylene glycol ether phosphate), MARLOWET 5301 (coconut oil polyethylene glycol ether phosphate), ATLAS G-2203 (potassium salt of phosphate), FOSFODET 1214 N / 16 (ethoxylated fatty alcohol phosphate).

[0170] In some embodiments, the alkyl polyalkylene glycol ether phosphate form is Hostaphart. ® 1306.

[0171] In some other embodiments, the alcohol ethoxylate is selected from Tergitol 15-S-7, Tergitol 15-S-9, Tergitol 15-S-12 and compounds having the following structures: , where m + n = 15 and x is the number of repeating ethoxylate (EO) units.

[0172] In some embodiments, the alcohol ethoxylate is Tergitol 15-S-7.

[0173] In some embodiments, the dispersant is selected from polyelectrolyte comb copolymers, EO-PO copolymers, polymethyl methacrylate-polyethylene glycol graft copolymers, tristyrylphenol ethoxylate in phosphate form, and polyoxyethylene sorbitol ester.

[0174] In some other embodiments, the dispersant system comprises a combination of a polyelectrolyte comb copolymer surfactant and at least one other dispersant.

[0175] In some embodiments, at least one other dispersant is selected from polyelectrolyte comb copolymers, EO-PO copolymers, polymethyl methacrylate-polyethylene glycol graft copolymers, tristyrylphenol ethoxylate in phosphate form, and polyoxyethylene sorbitol ester.

[0176] In some embodiments, the polyelectrolyte comb copolymer is the polyelectrolyte disclosed in application publication WO 2017 / 098325, the entire contents of which are incorporated herein by reference.

[0177] In some embodiments, the polyelectrolyte comb copolymer comprises a hydrophobic anchoring portion and at least one hydrophilic charged stabilizing portion.

[0178] In some embodiments, the hydrophilic charged stabilizing portion comprises at least one charged monomer, preferably an anionic monomer having a sulfonate group.

[0179] In some embodiments, the molar ratio of the hydrophobic anchoring portion to the hydrophilic charged stabilizing portion is 1:2-4.

[0180] In some embodiments, the weight ratio of the hydrophobic anchoring portion to the hydrophilic charged stabilizing portion is less than 0.6.

[0181] In some embodiments, the polyelectrolyte comb copolymer is PolyAgroA.

[0182] In some other embodiments, the EO-PO copolymer is selected from Ethylan NS 500 (polyalkoxylated butyl ether), Antarox B / 848 (ethylene oxide, methyl-, and ethylene oxide polymer), Ultraic 5000 HM (ethoxylated and propoxylated alcohols), Toximul 8350 (polyethylene glycol-polypropylene glycol monobutyl ether), Tergitol XD (ethylene oxide / propylene oxide block copolymer), Atlas G-5000-SO-(CQ) (ethylene oxide, 2-methyl-, and ethylene oxide polymer, monobutyl ether), Atlas G-5002L-LQ-(CQ) (ethylene oxide, monobutyl ether), SYNERGEN 848 (block polyoxyalkylene oxide), Ethylan 992, and Ultraric 5000 HM (EU source) (polyethylene glycol-polypropylene glycol monobutyl ether).

[0183] In some other embodiments, the polymethyl methacrylate-polyethylene glycol graft copolymer is selected from Atlox 4913, STEP-FLOW 3000, STEP-FLOW 4000 and Tersperse 2500.

[0184] In some embodiments, the tristyrylphenol ethoxylate phosphate form is selected from Soprophor 3D33, Soprophor FL, Surfom 1322 SC, Agnique PE TSP 16T and Dispersogen TP 160T.

[0185] In some embodiments, polyoxyethylene sorbitol ester is selected from Tween 20, Hostacerin L 20, Hostacerin L 20 SG Vita, Alkamuls T 20, Emulsogen 4156, and Alkest TW 20.

[0186] In some embodiments, the dispersant and the wetting agent are the same.

[0187] In some embodiments, the dispersant and the wetting agent are different.

[0188] In some embodiments, the composition is highly loaded.

[0189] In some embodiments, high loading means that the composition contains an amount of active ingredient greater than 30% w / w based on the total weight of the composition.

[0190] In some embodiments, the amount of fluorourea is 5-60% w / w based on the total weight of the composition. In some embodiments, the amount of fluorourea is 10-60% w / w based on the total weight of the composition. In some embodiments, the amount of fluorourea is 15-60% w / w based on the total weight of the composition. In some embodiments, the amount of fluorourea is 20-60% w / w based on the total weight of the composition. In some embodiments, the amount of fluorourea is 25-60% w / w based on the total weight of the composition. In some embodiments, the amount of fluorourea is 30-60% w / w based on the total weight of the composition. In some embodiments, the amount of fluorourea is 35-60% w / w based on the total weight of the composition. In some embodiments, the amount of fluorourea is 35-55% w / w based on the total weight of the composition. In some embodiments, the amount of fluorourea is 35-50% w / w based on the total weight of the composition. In some embodiments, the amount of fluorourea is 40-60% w / w based on the total weight of the composition. In some embodiments, the amount of fluorourea is 40-55% w / w based on the total weight of the composition. In some embodiments, the amount of fluorourea is 40-50% w / w based on the total weight of the composition. In some embodiments, the amount of fluorourea is 40% w / w based on the total weight of the composition. In some embodiments, the amount of fluorourea is 50% w / w based on the total weight of the composition. In some embodiments, the amount of fluorourea is 55% w / w based on the total weight of the composition. In some embodiments, the amount of fluorourea is 60% w / w based on the total weight of the composition.

[0191] In some embodiments, the amount of fluorourea is between about 350 g / L and about 750 g / L based on the total weight of the composition. In some embodiments, the amount of fluorourea is between about 400 g / L and about 800 g / L based on the total weight of the composition. In some embodiments, the amount of fluorourea is between about 400 g / L and about 700 g / L based on the total weight of the composition. In some embodiments, the amount of fluorourea is between about 400 g / L and about 600 g / L based on the total weight of the composition. The amount of fluorourea can be an intermediate range selected from any of the ratios specified above. In some embodiments, the amount of fluorourea is about 780 g / L based on the total weight of the composition. In some embodiments, the amount of fluorourea is about 750 g / L based on the total weight of the composition. In some embodiments, the amount of fluorourea is about 700 g / L based on the total weight of the composition. In some embodiments, the amount of fluorourea is about 650 g / L based on the total weight of the composition. In some embodiments, the amount of fluorourea is about 600 g / L based on the total weight of the composition. In some embodiments, the amount of fluorourea is about 550 g / L based on the total weight of the composition. In some embodiments, the amount of fluorourea is about 500 g / L based on the total weight of the composition. In some embodiments, the amount of fluorourea is about 450 g / L based on the total weight of the composition. In some embodiments, the amount of fluorourea is about 400 g / L based on the total weight of the composition. In some embodiments, the amount of fluorourea is about 350 g / L based on the total weight of the composition. This amount can be any intermediate value or intermediate range selected from the specified amount.

[0192] In some embodiments, the total amount of the wetting agent system is 1.5-10% w / w based on the total weight of the composition. In some embodiments, the total amount of the wetting agent system is 1.5-7.5% w / w based on the total weight of the composition. In some embodiments, the total amount of the wetting agent system is 1.5-6% w / w based on the total weight of the composition. In some embodiments, the total amount of the wetting agent system is about 4.5% w / w based on the total weight of the composition. In some embodiments, the total amount of the wetting agent system is about 7.5% w / w based on the total weight of the composition. This amount can be any intermediate value or range selected from the specified amounts.

[0193] In some embodiments, the total amount of the dispersant system is 2-12% w / w based on the total weight of the composition. In some embodiments, the total amount of the dispersant system is 2-10% w / w based on the total weight of the composition. In some embodiments, the total amount of the dispersant system is 2-8% w / w based on the total weight of the composition. In some embodiments, the total amount of the dispersant system is about 5% w / w based on the total weight of the composition. This amount can be any intermediate value or range selected from the specified amounts.

[0194] In some embodiments, the amount of alkyl polyethylene glycol ether phosphate mono / diester (50 / 50) acid is 1-4% w / w based on the total weight of the composition. This amount can be any intermediate value or range selected from the specified amount.

[0195] In some embodiments, the amount of polyether trisiloxane is 0.5-2% w / w based on the total weight of the composition. This amount can be any intermediate value or range selected from the specified amount.

[0196] In some embodiments, the amount of EO-PO copolymer is 1-4% w / w based on the total weight of the composition. This amount can be any intermediate value or range selected from the specified amount.

[0197] In some embodiments, the amount of polymethyl methacrylate-polyethylene glycol graft copolymer is 1-4% w / w based on the total weight of the composition. This amount can be any intermediate value or range selected from the specified amount.

[0198] In some embodiments, the amount of the polyelectrolyte comb copolymer is 1-4% w / w based on the total weight of the composition. This amount can be any intermediate value or range selected from the specified amount.

[0199] In some embodiments, the amount of tristyrylphenol ethoxylate in phosphate form is 1-4% w / w based on the total weight of the composition. This amount can be any intermediate value or range selected from the specified amount.

[0200] In some embodiments, the amount of polyoxyethylene sorbitol ester is 1-4% w / w based on the total weight of the composition. This amount can be any intermediate value or range selected from the specified amount.

[0201] In some embodiments, the weight ratio of the wetting agent system to fluorourea in the composition is 1:40 to 1.6:1. In some embodiments, the weight ratio of the wetting agent system to fluorourea in the composition is 1:40 to 1.5:1. In some embodiments, the weight ratio of the wetting agent system to fluorourea in the composition is 1:40 to 1.2:1. In some embodiments, the weight ratio of the wetting agent system to fluorourea in the composition is 1:40 to 1:1.6. In some embodiments, the weight ratio of the wetting agent system to fluorourea in the composition is 1:40 to 1:2.5. In some embodiments, the weight ratio of the wetting agent system to fluorourea in the composition is 1:40 to 1:3.33. In some embodiments, the weight ratio of the wetting agent system to fluorourea in the composition is 1:40 to 1:4.2. In some embodiments, the weight ratio of the wetting agent system to fluorourea in the composition is 1:40 to 1:5. In some embodiments, the weight ratio of the wetting agent system to fluorourea in the composition is 1:40 to 1:6. In some embodiments, the weight ratio of the wetting agent system to fluorourea in the composition is 1:36 to 1:1.6. In some embodiments, the weight ratio of the wetting agent system to fluorourea in the composition is 1:33 to 1:1.6. In some embodiments, the weight ratio of the wetting agent system to fluorourea in the composition is about 1:9. In some embodiments, the weight ratio of the wetting agent system to fluorourea in the composition is about 1:12. In some embodiments, the weight ratio of the wetting agent system to fluorourea in the composition is about 1:13. The weight ratio can be any intermediate value or range selected from the specified ratio.

[0202] In some embodiments, the weight ratio between the two wetting agents in the composition is from 8:1 to 1:2. The weight ratio can be selected from an intermediate range of the specified ratio.

[0203] In some embodiments, the weight ratio between the two dispersants in the composition is from 4:1 to 1:4. The weight ratio can be selected from an intermediate range of the specified ratio.

[0204] In some embodiments, the weight ratio of alkyl polyethylene glycol ether phosphate mono / diester (50 / 50) acid to fluorourea in the composition is 1:60 to 1:1.25. In some embodiments, the weight ratio of alkyl polyethylene glycol ether phosphate mono / diester (50 / 50) acid to fluorourea in the composition is 1:60 to 1:2.5. In some embodiments, the weight ratio of alkyl polyethylene glycol ether phosphate mono / diester (50 / 50) acid to fluorourea in the composition is 1:60 to 1:3.75. In some embodiments, the weight ratio of alkyl polyethylene glycol ether phosphate mono / diester (50 / 50) acid to fluorourea in the composition is 1:60 to 1:5. In some embodiments, the weight ratio of alkyl polyethylene glycol ether phosphate mono / diester (50 / 50) acid to fluorourea in the composition is 1:60 to 1:6.25. In some embodiments, the weight ratio of alkyl polyethylene glycol ether phosphate mono / diester (50 / 50) acid to fluorourea in the composition is 1:60 to 1:7.5. In some embodiments, the weight ratio of alkyl polyethylene glycol ether phosphate mono / diester (50 / 50) acid to fluorourea in the composition is 1:60 to 1:8.75. In some embodiments, the weight ratio of alkyl polyethylene glycol ether phosphate mono / diester (50 / 50) acid to fluorourea in the composition is 1:55 to 1:8.75. In some embodiments, the weight ratio of alkyl polyethylene glycol ether phosphate mono / diester (50 / 50) acid to fluorourea in the composition is 1:50 to 1:8.75. In some embodiments, the weight ratio of alkyl polyethylene glycol ether phosphate mono / diester (50 / 50) acid to fluorourea in the composition is about 1:30. In some embodiments, the weight ratio of the alkyl polyethylene glycol ether phosphate mono / diester (50 / 50) acid form to the fluorourea in the composition is about 1:26. In some embodiments, the weight ratio of the alkyl polyethylene glycol ether phosphate mono / diester (50 / 50) acid form to the fluorourea in the composition is about 1:20. The weight ratio can be any intermediate value or intermediate range selected from the specified ratio.

[0205] In some embodiments, the weight ratio of polyether trisiloxane to fluorourea in the composition is 1:120 to 1:2.5. In some embodiments, the weight ratio of polyether trisiloxane to fluorourea in the composition is 1:120 to 1:5. In some embodiments, the weight ratio of polyether trisiloxane to fluorourea in the composition is 1:120 to 1:7.5. In some embodiments, the weight ratio of polyether trisiloxane to fluorourea in the composition is 1:120 to 1:10. In some embodiments, the weight ratio of polyether trisiloxane to fluorourea in the composition is 1:120 to 1:12.5. In some embodiments, the weight ratio of polyether trisiloxane to fluorourea in the composition is 1:120 to 1:15. In some embodiments, the weight ratio of polyether trisiloxane to fluorourea in the composition is 1:120 to 1:17.5. In some embodiments, the weight ratio of polyether trisiloxane to fluorourea in the composition is from 1:110 to 1:17.5. In some embodiments, the weight ratio of polyether trisiloxane to fluorourea in the composition is from 1:100 to 1:17.5. In some embodiments, the weight ratio of polyether trisiloxane to fluorourea in the composition is about 1:60. In some embodiments, the weight ratio of polyether trisiloxane to fluorourea in the composition is about 1:53. In some embodiments, the weight ratio of polyether trisiloxane to fluorourea in the composition is about 1:40.

[0206] In some embodiments, the weight ratio between the alkyl polyethylene glycol ether phosphate mono / diester (50 / 50) acid form and the polyether trisiloxane in the composition is from 8:1 to 1:2. The weight ratio can be any intermediate value or range selected from the specified ratio.

[0207] In some embodiments, when the wetting agent system further comprises an alcohol ethoxylate, the amount of the alcohol ethoxylate is 1-4% w / w based on the total weight of the composition. This amount can be any intermediate value or range selected from the specified amounts.

[0208] In some embodiments, the weight ratio of the dispersant system to fluorourea in the composition is from 1:30 to 1.6:1. The weight ratio can be an intermediate range selected from any of the specified ratios. In some embodiments, the weight ratio of the dispersant system to fluorourea in the composition is from 1:30 to 1:1.25. In some embodiments, the weight ratio of the dispersant system to fluorourea in the composition is from 1:30 to 1:1.875. In some embodiments, the weight ratio of the dispersant system to fluorourea in the composition is from 1:30 to 1:2.5. In some embodiments, the weight ratio of the dispersant system to fluorourea in the composition is from 1:30 to 1:3.125. In some embodiments, the weight ratio of the dispersant system to fluorourea in the composition is from 1:30 to 1:3.75. In some embodiments, the weight ratio of the dispersant system to fluorourea in the composition is from 1:30 to 1:4.375. In some embodiments, the weight ratio of the dispersant system to fluorourea in the composition is from 1:27.5 to 1:4.375. In some embodiments, the weight ratio of the dispersant system to fluorourea in the composition is from 1:25 to 1:4.375. In some embodiments, the weight ratio of the dispersant system to fluorourea in the composition is 1:8. In some embodiments, the weight ratio of the dispersant system to fluorourea in the composition is 1:10. In some embodiments, the weight ratio of the dispersant system to fluorourea in the composition is 1:12. The weight ratio can be any intermediate value or range selected from the specified ratio.

[0209] In some embodiments, the weight ratio of the dispersants in the composition is from 4:1 to 1:4.

[0210] In some embodiments, the weight ratio between the polyelectrolyte comb copolymer and the additional dispersant in the composition is from 4:1 to 1:4.

[0211] In some embodiments, the weight ratio of the polyelectrolyte comb copolymer to fluorourea in the composition is 1:60 to 1:1.25. In some embodiments, the weight ratio of the polyelectrolyte comb copolymer to fluorourea in the composition is 1:60 to 1:2.5. In some embodiments, the weight ratio of the polyelectrolyte comb copolymer to fluorourea in the composition is 1:60 to 1:3.75. In some embodiments, the weight ratio of the polyelectrolyte comb copolymer to fluorourea in the composition is 1:60 to 1:5. In some embodiments, the weight ratio of the polyelectrolyte comb copolymer to fluorourea in the composition is 1:60 to 1:6.25. In some embodiments, the weight ratio of the polyelectrolyte comb copolymer to fluorourea in the composition is 1:60 to 1:7.5. In some embodiments, the weight ratio of the polyelectrolyte comb copolymer to fluorourea in the composition is 1:60 to 1:8.75. In some embodiments, the weight ratio of the polyelectrolyte comb copolymer to fluorourea in the composition is from 1:55 to 1:8.75. In some embodiments, the weight ratio of the polyelectrolyte comb copolymer to fluorourea in the composition is from 1:50 to 1:8.75. In some embodiments, the weight ratio of the polyelectrolyte comb copolymer to fluorourea in the composition is about 1:30. In some embodiments, the weight ratio of the polyelectrolyte comb copolymer to fluorourea in the composition is about 1:26. In some embodiments, the weight ratio of the polyelectrolyte comb copolymer to fluorourea in the composition is about 1:20. The weight ratio can be any intermediate value or intermediate range selected from the specified ratios. The weight ratio can be an intermediate range selected from any of the specified ratios.

[0212] In some embodiments, the weight ratio of the additional dispersant to fluorourea in the composition is 1:60 to 1:1.25. In some embodiments, the weight ratio of the additional dispersant to fluorourea in the composition is 1:60 to 1:2.5. In some embodiments, the weight ratio of the additional dispersant to fluorourea in the composition is 1:60 to 1:3.75. In some embodiments, the weight ratio of the additional dispersant to fluorourea in the composition is 1:60 to 1:5. In some embodiments, the weight ratio of the additional dispersant to fluorourea in the composition is 1:60 to 1:6.25. In some embodiments, the weight ratio of the additional dispersant to fluorourea in the composition is 1:60 to 1:7.5. In some embodiments, the weight ratio of the additional dispersant to fluorourea in the composition is 1:60 to 1:8.75. In some embodiments, the weight ratio of the additional dispersant to fluorourea in the composition is from 1:55 to 1:8.75. In some embodiments, the weight ratio of the additional dispersant to fluorourea in the composition is from 1:50 to 1:8.75. In some embodiments, the weight ratio of the additional dispersant to fluorourea in the composition is about 1:30. In some embodiments, the weight ratio of the additional dispersant to fluorourea in the composition is about 1:26. In some embodiments, the weight ratio of the additional dispersant to fluorourea in the composition is about 1:20. In some embodiments, the weight ratio of the additional dispersant to fluorourea in the composition is about 1:16. In some embodiments, the weight ratio of the additional dispersant to fluorourea in the composition is about 1:13. The weight ratio can be any intermediate value or range selected from the specified ratio.

[0213] In some embodiments, the composition is a suspension concentrate (SC). In some embodiments, the composition is an aqueous suspension. In some embodiments, the composition is a suspension emulsion (SE). In some embodiments, fluorourea is dispersed in an aqueous carrier. In some embodiments, fluorourea is partially dispersed in an aqueous carrier and partially dissolved in an organic carrier.

[0214] In some embodiments, the composition is a highly loaded SC composition.

[0215] In some embodiments, the composition is a highly loaded SE composition.

[0216] In some embodiments, the density of the SC composition is between 1 and 1.5 g / ml. The density may be an intermediate range selected from the specified range.

[0217] In some embodiments, the density of the SE composition is between 1 and 1.5 g / ml. The density may be an intermediate range selected from the specified range.

[0218] In some embodiments, the density of the SC composition is about 1.3 g / ml.

[0219] In some embodiments, the density of the SE composition is about 1.3 g / ml.

[0220] In some embodiments, the density of the SC composition is about 1.2 g / ml.

[0221] In some embodiments, the density of the SE composition is about 1.2 g / ml.

[0222] In some embodiments, the composition further comprises at least one agriculturally acceptable additive. Agriculturally acceptable additives include, but are not limited to, one or more carriers, one or more defoamers, one or more antifreeze agents, one or more stabilizers, one or more preservatives, one or more thickeners, and any combination thereof.

[0223] In some embodiments, the composition further comprises one or more adjuvants. In some embodiments, the adjuvant is a penetrant. In some embodiments, the adjuvant enhances the penetration of the active ingredient. In some embodiments, the adjuvant is a spreader. In some embodiments, the adjuvant improves the dispersion of the active ingredient on the leaf.

[0224] In some embodiments, agriculturally acceptable additives are compounds known in the art and accepted for forming liquid compositions for agricultural or horticultural use.

[0225] In some embodiments, the carrier is water.

[0226] In some embodiments, one or more defoamers are selected from Silcolapse 432 and SAG 1572.

[0227] In some embodiments, one or more antifreeze agents are selected from propylene glycol and glycerin.

[0228] In some embodiments, one or more stabilizers are magnesium aluminum silicate (montmorillonite clay) selected from Van Gel B.

[0229] In some embodiments, one or more preservatives are selected from Proxel GXL, Nipacide BIT AS 20, Amebact B 20, Biotrend CMT1.5, Rocima BT 25 microbial agent, and Wancide 520XL.

[0230] In some embodiments, one or more thickeners are selected from one or more polysaccharides: xanthan gum, Kelzan, Kelzan Advanced Performance, AG RH 23, Kelzan AP-AS, Kelzan HP, Rheozan, Rhodopol 23, Rhodopol 50 MC, Rhodopol MD 50, Rhodopol G, Rhodicare D, XCDBiopolymer, AG-RHO POL 23 / W.

[0231] In some embodiments, one or more thickeners are carboxymethyl cellulose, Cabosil, Bentone MA, or Bentone LT.

[0232] In some embodiments, one or more adjuvants are selected from Silwet. ® L77, Silwet 806, BREAK-THRU ® S 240, BREAK-THRU ® S 233 is a silicone-based surfactant.

[0233] In some embodiments, one or more adjuvants are Alkamuls AP, Synergen SOC, soybean methyl oleate, or Steposol ME.

[0234] In some embodiments, the amount of additive is 8-15% w / w based on the total weight of the composition.

[0235] In some embodiments, the amount of the adjuvant is 4-20% w / w based on the total weight of the composition. In some embodiments, the amount of the adjuvant is about 10% w / w based on the total weight of the composition. In some embodiments, the amount of the adjuvant is about 5% w / w based on the total weight of the composition.

[0236] In some embodiments, the present invention provides a suspension concentrate composition comprising:

[0237] a) Based on approximately 35-60% w / w of fluorouracil by weight of the total composition,

[0238] b) A system of at least two wetting agents in an amount of about 1.5-6% w / w of the total weight of the composition; and

[0239] c) A system of at least two dispersants in an amount of about 2-8% w / w of the total weight of the composition.

[0240] In some embodiments, the present invention provides a suspension concentrate composition comprising:

[0241] a) Based on a total weight of approximately 35-50% w / w of fluorourea in the composition,

[0242] b) A system of at least two wetting agents in an amount of about 1.5-6% w / w of the total weight of the composition; and

[0243] c) A system of at least two dispersants in an amount of about 2-8% w / w of the total weight of the composition.

[0244] In some embodiments, the present invention provides a water-dispersible composition comprising:

[0245] a) Based on approximately 58% w / w of the total weight of the composition, fluorouracil,

[0246] b) Based on approximately 1.5% w / w of Tergitol 15-S-7 by total weight of the composition,

[0247] c) Hostaphat at approximately 2% w / w of the total weight of the composition. ® 1306,

[0248] d) Based on approximately 1% w / w of the total weight of the composition, BreakThru S-240,

[0249] e) Based on 3% w / w of the total weight of the composition, and

[0250] f) PolyAgroA in an amount of approximately 2% w / w based on the total weight of the composition.

[0251] In some embodiments, the suspension concentrate is physically stable.

[0252] In some embodiments, the physical stability of a suspension refers to the state when the fluorourea particles are dispersed and / or dissolved and do not float on the water surface.

[0253] In some embodiments, physical stability is evaluated after storage at 54°C for 14 days.

[0254] In some embodiments, the viscosity of the composition is less than 3000 cps. In some embodiments, the viscosity of the composition is less than 2500 cps. In some embodiments, the viscosity of the composition is less than 2000 cps. In some embodiments, the viscosity of the composition is less than 1500 cps. In some embodiments, the viscosity of the composition is less than 1000 cps. In some embodiments, the viscosity of the composition is less than 800 cps. In some embodiments, the viscosity of the composition is less than 700 cps. In some embodiments, the viscosity of the composition is less than 600 cps. In some embodiments, the viscosity of the composition is less than 500 cps. Viscosity can be an intermediate range selected from any specified value.

[0255] In some embodiments, one or more adjuvants are added to the SC composition “as is”, and the amount of one or more adjuvants is 1-20% w / w. In some embodiments, the amount of adjuvant is 5%-10% w / w based on the total weight of the composition.

[0256] In some embodiments, the adjuvant is formulated separately as an emulsion concentrate (EC).

[0257] In some embodiments, the SC composition comprises an auxiliary EC composition.

[0258] In some embodiments, the adjuvant is dissolved in an organic solvent.

[0259] In some embodiments, the organic solvent is an oil.

[0260] In some embodiments, the amount of the adjuvant is 30-50% w / w based on the total weight of the EC composition containing the adjuvant.

[0261] In some embodiments, the adjuvant EC formulation further comprises an emulsifier.

[0262] In some embodiments, the emulsifier is selected from benzenesulfonic acid, mono-C11-13-branched alkyl derivatives, and NINATE. ® Calcium salts of 401-ND.

[0263] In some embodiments, the emulsifier is sodium dioctyl sulfosuccinate selected from Emcol 4500, Lankropol KO2, Geropon CYA / 75, and DOSS 75E.

[0264] In some embodiments, the auxiliary EC formulation comprises oil.

[0265] In some embodiments, the oil is soybean oil selected from soybean oil fatty acid methyl esters and Steposol ME.

[0266] In some embodiments, the present invention provides an SE composition.

[0267] In some embodiments, the SE composition is a mixture of the SC fluorourea composition and the EC fluorourea composition. In some embodiments, the fluorourea is partially dispersed in water and partially dissolved in the oil phase.

[0268] In some embodiments, the SE composition is a mixture of the SC fluorourea composition and the EC adjuvant mixture. In some embodiments, the fluorourea is partially dispersed in water and partially dissolved in the EC adjuvant mixture.

[0269] In some embodiments, the amount of fluorourea dispersed in water in the SE formulation is between 25% and 60% by weight of the composition.

[0270] In some embodiments, the amount of fluorourea dissolved in the EC mixture in the SE formulation is between 1% and 10% by weight of the composition.

[0271] In some embodiments, the present invention provides an SE composition comprising:

[0272] a) Based on a total weight of approximately 35-50% w / w of fluorourea in the composition,

[0273] b) A system of at least two wetting agents in an amount of about 1.5-6% w / w of the total weight of the composition.

[0274] c) At least two dispersants in amounts of about 2-8% w / w of the total weight of the composition, and

[0275] d) An amount of adjuvants of approximately 4-7% w / w based on the total weight of the composition.

[0276] In some embodiments, the present invention provides an SE composition comprising:

[0277] e) Based on approximately 35% w / w of the total weight of the composition, fluorouracil,

[0278] f) A system of at least two wetting agents in an amount of about 1.4% w / w of the total weight of the composition;

[0279] g) A system of at least two dispersants in an amount of about 5% w / w of the total weight of the composition; and

[0280] h) An auxiliary agent in an amount of approximately 4% w / w based on the total weight of the composition.

[0281] Use:

[0282] In another aspect, the present invention provides the use of the compositions described herein for treating plants.

[0283] In some embodiments, the plant is a pest-sensitive crop.

[0284] In some embodiments, the pesticide-sensitive crop is cucumber. In some embodiments, the pesticide-sensitive crop is lettuce. In some embodiments, the pesticide-sensitive crop is pepper. In some embodiments, the pesticide-sensitive crop is cabbage. In some embodiments, the pesticide-sensitive crop is gourd. In some embodiments, the pesticide-sensitive crop is wine grape. In some embodiments, the pesticide-sensitive crop is cotton. In some embodiments, the pesticide-sensitive crop is corn. In some embodiments, the pesticide-sensitive crop is soybean.

[0285] In some embodiments, the composition is obtained using one of the preparation methods described herein.

[0286] In another aspect, the present invention provides a method for treating plants, the method comprising (1) obtaining a composition as described herein and (2) contacting the plant with an effective amount of the composition.

[0287] The present invention also provides a method for controlling harmful insects, the method comprising applying an effective amount of the composition described herein to plants or areas infested by harmful insects in order to control the harmful insects.

[0288] In some embodiments, the composition is applied at a ratio of about 100 ppm to about 1000 ppm of fluorouracil. In some embodiments, the composition is applied at a ratio of about 100 ppm to about 500 ppm of fluorouracil. In some embodiments, the composition is applied at a ratio of about 200 ppm to about 400 ppm of fluorouracil. In some embodiments, the composition is applied at a ratio of about 200 ppm of fluorouracil. In some embodiments, the composition is applied at a ratio of about 200-500 ppm of fluorouracil.

[0289] In some embodiments, the composition is applied at a ratio of about 40 g / ha to about 180 g / ha of fluorouracil.

[0290] In some embodiments, the composition is applied at a ratio of about 50 g / ha to about 150 g / ha of fluorouracil.

[0291] In some embodiments, the pesticide-sensitive crop is cucumber. In some embodiments, the pesticide-sensitive crop is lettuce. In some embodiments, the pesticide-sensitive crop is pepper. In some embodiments, the pesticide-sensitive crop is cabbage. In some embodiments, the pesticide-sensitive crop is gourd. In some embodiments, the pesticide-sensitive crop is wine grape. In some embodiments, the pesticide-sensitive crop is cotton. In some embodiments, the pesticide-sensitive crop is corn. In some embodiments, the pesticide-sensitive crop is soybean.

[0292] In some embodiments, when the pest-sensitive crop is cucumber, the composition is applied at a ratio of about 40 g / ha to about 180 g / ha of flufenoxuron. In some embodiments, when the pest-sensitive crop is cucumber, the suspension is applied at a ratio of about 40 gr / ha to about 150 g / ha of flufenoxuron. In some embodiments, when the pest-sensitive crop is cucumber, the suspension is applied at a ratio of about 50 gr / ha to about 115 g / ha of flufenoxuron. In some embodiments, when the pest-sensitive crop is cotton, the composition is applied at a ratio of about 10 gr / ha to about 105 gr / ha of flufenoxuron. In some embodiments, when the pest-sensitive crop is corn, the composition is applied at a ratio of about 10 gr / ha to about 87.6 gr / ha of flufenoxuron. In some embodiments, when the pest-sensitive crop is soybean, the composition is applied at a ratio of about 35 gr / ha to about 87.6 gr / ha of flufenoxuron.

[0293] In some embodiments, when the pest-sensitive crop is lettuce, the composition is applied at a ratio of about 50 gr / ha to about 180 g / ha of flufenoxuron. In some embodiments, when the pest-sensitive crop is lettuce, the composition is applied at a ratio of about 50 gr / ha to about 150 g / ha of flufenoxuron. In some embodiments, when the pest-sensitive crop is lettuce, the composition is applied at a ratio of about 65 gr / ha to about 115 g / ha of flufenoxuron.

[0294] In some embodiments, when the pest-sensitive crop is pepper, the composition is applied at a ratio of about 40 g / ha to about 180 g / ha of flufenoxuron. In some embodiments, when the pest-sensitive crop is pepper, the composition is applied at a ratio of about 40 g / ha to about 150 g / ha of flufenoxuron. In some embodiments, when the pest-sensitive crop is pepper, the composition is applied at a ratio of about 50 g / ha to about 115 g / ha of flufenoxuron.

[0295] In some embodiments, when the pest-sensitive crop is cabbage, the composition is applied at a ratio of about 50 g / ha to about 200 g / ha of flufenoxuron. In some embodiments, when the pest-sensitive crop is cabbage, the composition is applied at a ratio of about 65 g / ha to about 115 g / ha of flufenoxuron.

[0296] In some embodiments, when the biocide-sensitive crop is gourd, the composition is applied at a ratio of about 40 g / ha to about 150 g / ha of flufenoxuron. In some embodiments, when the biocide-sensitive crop is gourd, the composition is applied at a ratio of about 50 g / ha to about 115 g / ha of flufenoxuron.

[0297] In some embodiments, when the biopesticide-sensitive crop is wine grape, the composition is applied at a ratio of about 40 g / ha to about 130 g / ha of flufenoxuron. In some embodiments, when the biopesticide-sensitive crop is wine grape, the composition is applied at a ratio of about 50 g / ha to about 100 g / ha of flufenoxuron.

[0298] In some embodiments, the composition is applied once during the growing season.

[0299] In some embodiments, the composition is applied at least once during the growing season.

[0300] In some embodiments, the composition is applied two or more times during the growing season.

[0301] In some embodiments, the composition is applied to the soil. In some embodiments, the composition or combination is applied to the leaves.

[0302] In some embodiments, the composition is applied at a ratio of about 100 ppm to about 1000 ppm of fluorouracil. In some embodiments, the composition is applied at a ratio of about 100 ppm to about 500 ppm of fluorouracil. In some embodiments, the composition is applied at a ratio of about 200 ppm to about 400 ppm of fluorouracil. In some embodiments, the composition is applied at a ratio of about 200 ppm of fluorouracil. In some embodiments, the composition is applied at a ratio of about 200-500 ppm of fluorouracil.

[0303] In some embodiments, the composition is applied to the soil. In some embodiments, the composition is applied to the leaves.

[0304] The compositions, uses, and methods described herein are particularly effective for controlling insects, especially those belonging to the orders Lepidoptera, Coleoptera, Homoptera, Heteroptera, Diptera, Thysanoptera, Orthoptera, Psyllids, Fleas, Trichophagoptera, Thysanura, Isoptera, Pseudoratida, and Hymenoptera, as well as representatives of the orders Ixodidae (hard ticks, soft ticks, Tetranychidae, and Dermatophytes), and leafrollers.

[0305] The compositions, uses, and methods described herein are also effective in controlling flies (e.g., houseflies), termites, cockroaches, and mosquito larvae.

[0306] The compositions, uses, and methods described herein are also suitable for controlling plant-destructive feeding insects in ornamental and useful plant crops, particularly cotton (e.g., against the sea tussock moth and tobacco shoot moth), and fruits and vegetables (e.g., against the apple leafroller (Laspeyresia pomonella), codling moth, apple leafminer (Lithocolletis blancardella), apple leafminer (Stigmella malella), cotton brown leafroller (adoxophyes orana), pear psylla (Psylla piri), apple heteromorphic leafroller (Cryptophlebia leucotreta), citrus leafminer (phyllocnistis citrella), pear fruit moth (Cydia molesta), peach branch moth (Anarsialineatella), potato beetle, and Mexican bean ladybug (Epilachna varivestis)), as well as controlling several mites, such as the olive mite (oleivora).

[0307] The compositions disclosed herein can be applied to control and / or prevent various insects in the presence of plants.

[0308] In some embodiments, the plant is a crop. In some embodiments, the plant is a pest-sensitive crop. In some embodiments, the crop is a soft crop such as vegetables and fruits.

[0309] The method of this invention can be used on any crop, including but not limited to monocotyledonous plants such as sugarcane, cereals, rice, corn, and / or dicotyledonous crops such as sugar beets (e.g., beets or forage beets); fruits (e.g., pome, drupe, or soft fruits, such as apples, pears, plums, peaches, almonds, cherries, strawberries, raspberries, or blackberries); legumes (e.g., beans, lentils, peas, or soybeans); and oil crops (e.g., rapeseed, mustard, poppies, olives, sunflowers, coconuts, castor oil plants, cocoa beans, or peanuts). Cucumber-like plants (such as zucchini, cucumber, or cantaloupe); fiber plants (such as cotton, flax, hemp, or jute); citrus fruits (such as wine grapes, oranges, lemons, grapefruits, or tangerines); vegetables (such as spinach, lettuce, cabbage, carrots, tomatoes, potatoes, gourds, or peppers); Lauraceae (such as avocados, cinnamon, or camphor); tobacco; nuts; coffee; tea; vines; hops; durian; bananas; natural rubber plants; and ornamental plants (such as flowering plants, shrubs, broad-leaved trees, or evergreen trees, such as pines and cypresses).

[0310] In some embodiments, the plant is a monocotyledonous plant, more preferably a cereal. In one specific embodiment, the cereal crop is wheat. In another specific embodiment, the cereal crop is black wheat. In another specific embodiment, the cereal crop is rye. In another specific embodiment, the cereal crop is oats. In another embodiment, the cereal crop is barley. In another embodiment, the crop plant is rice. In yet another embodiment, the crop plant is sugarcane. In still another embodiment, the crop plant is corn.

[0311] The compositions, uses, and methods described herein are further effective for controlling ectoparasites in livestock and breeding animals, such as Green bottle flies, for example, by treating animal skin, cattle sheds, barns, stables, and pasture.

[0312] Method of preparation:

[0313] In another aspect, the present invention provides a method for preparing the composition described herein, the method comprising mixing a wetting agent, a dispersant, a fluorourea and water.

[0314] In some embodiments, the method includes optionally adjusting the pH of the composition.

[0315] In some embodiments, the pH of the composition is between 5 and 8.

[0316] In some embodiments, concentrated NaOH solution and / or concentrated HCl solution are used to adjust the pH.

[0317] In some embodiments, the method includes: (1) mixing a wetting agent, a dispersant, an additive and water, and (2) adding fluorourea.

[0318] In some embodiments, fluorourea is added gradually.

[0319] In some embodiments, the mixture is ground. The grinding method is wet grinding.

[0320] In some embodiments, the grinding method yields a particle size D90 between 2 and 10 micrometers, preferably between 4 and 7 micrometers.

[0321] In some embodiments, the method includes high shear.

[0322] In some embodiments, the method includes mixing the SC composition as described herein with an adjuvant formulated "as is".

[0323] In some embodiments, the method includes mixing an SC composition as described herein with an adjuvant formulated as an EC as described herein.

[0324] In some embodiments, a method for preparing EC formulations includes mixing an adjuvant with a solvent and at least one emulsifier.

[0325] Example

[0326] Example 1: Fluorouracil 56.1% + Tergitol 15-S-7 + Atlox 4913

[0327]

[0328] Production method:

[0329] 1. Add Van Gel B to the water and apply high shear.

[0330] 2. Add half of Tergitol 15-S-7, Atlox 4913, Silcolapse 432, and propylene glycol and apply high shear.

[0331] 3. Add fluorourea gradually while stirring.

[0332] 4. Apply high shear

[0333] 5. Grind the mixture until the particle size is less than 5 micrometers (D90 < 5 micrometers).

[0334] 6. Calculate the grinding factor.

[0335] 7. If necessary, adjust the pH to 6-7 using concentrated NaOH / HCl solution.

[0336] 8. Seal the formulation by adding Silcolapse 432, 2% xanthan gum solution, Proxel GXL and the remaining water while stirring.

[0337] Example 2: Fluorouracil 56.1% + Tergitol 15-S-7 + Ethylan NS 500

[0338]

[0339] Production method:

[0340] 1. Add Van Gel B to the water and apply high shear.

[0341] 2. Add Tergitol 15-S-7, Ethylan NS 500, half of Silcolapse 432, propylene glycol and apply high shear.

[0342] 3. Add fluorourea gradually while stirring.

[0343] 4. Apply high shear

[0344] 5. Grind the mixture until the particle size is less than 5 micrometers (D90 < 5 micrometers).

[0345] 6. Calculate the grinding factor.

[0346] 7. If necessary, adjust the pH to 6-7 using concentrated NaOH / HCl solution.

[0347] 8. Seal the formulation by adding Silcolapse 432, 2% xanthan gum solution, Proxel GXL and the remaining water while stirring.

[0348] Example 3: Fluorouracil 56.1% + Tergitol 15-S-7 + Ethylan NS 500 + PolyAgroA

[0349]

[0350] Production method:

[0351] 1. Add Van Gel B to the water and apply high shear.

[0352] 2. Add Tergitol 15-S-7, Ethylan NS 500, half of Silcolapse 432, PolyAgroA, propylene glycol and apply high shear.

[0353] 3. Add fluorourea gradually while stirring.

[0354] 4. Apply high shear

[0355] 5. Grind the mixture until the particle size is less than 5 micrometers (D90 < 5 micrometers).

[0356] 6. Calculate the grinding factor.

[0357] 7. If necessary, adjust the pH to 6-7 using concentrated NaOH / HCl solution.

[0358] 8. Seal the formulation by adding Silcolapse 432, 2% xanthan gum solution, Proxel GXL and the remaining water while stirring.

[0359] Example 4: Fluorouracil 57.9% + Tergitol 15-S-7 + Ethylan NS 500 + PolyAgroA + BreakThru S-240.

[0360]

[0361] Production method:

[0362] 1. Add Van Gel B to the water and apply high shear.

[0363] 2. Add Tergitol 15-S-7, BreakThru S-240, Ethylan NS 500, half of Silcolapse 432, PolyAgroA, propylene glycol and apply high shear.

[0364] 3. Add fluorourea gradually while stirring.

[0365] 4. Apply high shear

[0366] 5. Grind the mixture until the particle size is less than 5 micrometers (D90 < 5 micrometers).

[0367] 6. Calculate the grinding factor.

[0368] 7. If necessary, adjust the pH to 6-7 using concentrated NaOH / HCl solution.

[0369] 8. Seal the formulation by adding Silcolapse 432, 2% xanthan gum solution, Proxel GXL and the remaining water while stirring.

[0370] Example 5: Fluorouracil 57.9% + Tergitol 15-S-7 + Ethylan NS 500 + PolyAgroA + Hostaphat 1306.

[0371]

[0372] Production method:

[0373] 1. Add Van Gel B to the water and apply high shear.

[0374] 2. Add Tergitol 15-S-7, Hostaphat 1306, Ethylan NS 500, half of Silcolapse 432, PolyAgroA, propylene glycol and apply high shear.

[0375] 3. Add fluorourea gradually while stirring.

[0376] 4. Apply high shear

[0377] 5. Grind the mixture until the particle size is less than 5 micrometers (D90 < 5 micrometers).

[0378] 6. Calculate the grinding factor.

[0379] 7. If necessary, adjust the pH to 6-7 using concentrated NaOH / HCl solution.

[0380] 8. Seal the formulation by adding Silcolapse 432, 2% xanthan gum solution, Proxel GXL and the remaining water while stirring.

[0381] Example 6: Fluorouracil 57.9% + Tergitol 15-S-7 + Hostapaht 1306 + BreakThru S-240 + Ethylan NS 500 + PolyAgroA

[0382]

[0383] Production method:

[0384] 1. Add Van Gel B to the water and apply high shear.

[0385] 2. Add Tergitol 15-S-7, Hostaphat 1306, BreakThru S-240, Ethylan NS 500, half of Silcolapse 432, PolyAgroA, propylene glycol and apply high shear.

[0386] 3. Add fluorourea gradually while stirring.

[0387] 4. Apply high shear

[0388] 5. Grind the mixture until the particle size is less than 5 micrometers (D90 < 5 micrometers).

[0389] 6. Calculate the grinding factor.

[0390] 7. If necessary, adjust the pH to 6-7 using concentrated NaOH / HCl solution.

[0391] 8. Seal the formulation by adding Silcolapse 432, 2% xanthan gum solution, Proxel GXL and the remaining water while stirring, and optionally leave a 5% gap in the water addition for the next step.

[0392] 9. Optionally, add 5% of the adjuvant by applying high shear.

[0393] Chemically stable formulations were obtained, as shown in the table below:

[0394] Stability test of Example 6 (fluorourea 57.9% + Tergitol 15-S-7 + Hostapaht 1306 + BreakThru S-240 + Ethylan NS 500 + PolyAgroA)

[0395]

[0396] Example 7: Fluorouracil 57.9% + Tergitol 15-S-7 + Hostaphat 1306 + BreakThru S-240 + PolyAgroA.

[0397]

[0398] Production method:

[0399] 1. Add Van Gel B to the water and apply high shear.

[0400] 2. Add Tergitol 15-S-7, Hostaphat 1306, half of Silcolapse 432, PolyAgroA, propylene glycol and apply high shear.

[0401] 3. Add fluorourea gradually while stirring.

[0402] 4. Apply high shear

[0403] 5. Grind the mixture until the particle size is less than 5 micrometers (D90 < 5 micrometers).

[0404] 6. Calculate the grinding factor.

[0405] 7. If necessary, adjust the pH to 6-7 using concentrated NaOH / HCl solution.

[0406] 8. Seal the formulation by adding Silcolapse 432, 2% xanthan gum solution, Proxel GXL and the remaining water while stirring, and optionally leave a 5% gap in the water addition for the next step.

[0407] 9. Optionally, add 5% of the adjuvant by applying high shear.

[0408] Example 8: Fluorouracil 57.9% + Tergitol 15-S-7 + Hostaphat 1306 + BreakThru S-240 + Ethylan NS 500.

[0409]

[0410] Production method:

[0411] 1. Add Van Gel B to the water and apply high shear.

[0412] 2. Add Tergitol 15-S-7, Hostaphat 1306, BreakThru S-240, Ethylan NS 500, half of Silcolapse 432, propylene glycol and apply high shear.

[0413] 3. Add fluorourea gradually while stirring.

[0414] 4. Apply high shear

[0415] 5. Grind the mixture until the particle size is less than 5 micrometers (D90 < 5 micrometers).

[0416] 6. Calculate the grinding factor.

[0417] 7. If necessary, adjust the pH to 6-7 using concentrated NaOH / HCl solution.

[0418] 8. Seal the formulation by adding Silcolapse 432, 2% xanthan gum solution, Proxel GXL and the remaining water while stirring.

[0419] Comparison between Examples 6 and 8:

[0420]

[0421] Formulations containing PolyAgroA (Example 6) are superior to formulations without PolyAgroA (Example 8). PolyAgroA reduces viscosity and is advantageous in terms of water dissolution.

[0422] Example 9: Fluorouracil 57.9% + Tergitol 15-S-7 + Hostaphat 1306 + BreakThru S-240 + Ethylan NS 500 + Atlox 4913

[0423]

[0424] Production method:

[0425] 1. Add Van Gel B to the water and apply high shear.

[0426] 2. Add Tergitol 15-S-7, Ethylan NS 500, half of Silcolapse 432, Atlox 4913, propylene glycol and apply high shear.

[0427] 3. Add fluorourea gradually while stirring.

[0428] 4. Apply high shear

[0429] 5. Grind the mixture until the particle size is less than 5 micrometers (D90 < 5 micrometers).

[0430] 6. Calculate the grinding factor.

[0431] 7. If necessary, adjust the pH to 6-7 using concentrated NaOH / HCl solution.

[0432] 8. Seal the formulation by adding Silcolapse 432, 2% xanthan gum solution, Proxel GXL and the remaining water while stirring.

[0433] Example 10: Fluorouracil 57.9% + Hostapaht 1306 + BreakThru S-240 + Ethylan NS500 + PolyAgroA

[0434]

[0435] Production method:

[0436] 1. Add Van Gel B to the water and apply high shear.

[0437] 2. Add Hostaphat 1306, BreakThru S-240, Ethylan NS 500, PolyAgroA, half of Silcolapse 432, propylene glycol and apply high shear.

[0438] 3. Add fluorourea gradually while stirring.

[0439] 4. Apply high shear

[0440] 5. Grind the mixture until the particle size is less than 5 micrometers (D90 < 5 micrometers).

[0441] 6. Calculate the grinding factor.

[0442] 7. If necessary, adjust the pH to 6-7 using concentrated NaOH / HCl solution.

[0443] 8. Seal the formulation by adding Silcolapse 432, 2% xanthan gum solution, Proxel GXL and the remaining water while stirring.

[0444] Example 11: Fluorouracil 57.9% + Tergitol 15-S-7 + Hostapaht 1306 + BreakThru S-240 + Atlox 4913 + PolyAgroA

[0445]

[0446] Production method:

[0447] 1. Add Van Gel B to the water and apply high shear.

[0448] 2. Add Tergitol 15-S-7, Hostaphat 1306, BreakThru S-240, Atlox 4913, half of Silcolapse 432, PolyAgroA, propylene glycol and apply high shear.

[0449] 3. Add fluorourea gradually while stirring.

[0450] 4. Apply high shear

[0451] 5. Grind the mixture until the particle size is less than 5 micrometers (D90 < 5 micrometers).

[0452] 6. Calculate the grinding factor.

[0453] 7. If necessary, adjust the pH to 6-7 using concentrated NaOH / HCl solution.

[0454] 8. Seal the formulation by adding Silcolapse 432, 2% xanthan gum solution, Proxel GXL and the remaining water while stirring, and optionally leave a 5% gap in the water addition for the next step.

[0455] 9. Optionally, add 5% of the adjuvant by applying high shear.

[0456] Example 12: Fluorouracil 57.9% + Tergitol 15-S-7 + Hostapaht 1306 + BreakThru S-240 + Soprophor 3D33 + PolyAgroA

[0457]

[0458] Production method:

[0459] 1. Add Van Gel B to the water and apply high shear.

[0460] 2. Add Tergitol 15-S-7, Hostaphart 1306, BreakThru S-240, Soprophor 3D33, half of Silcolapse 432, PolyAgroA, propylene glycol and apply high shear.

[0461] 3. Add fluorourea gradually while stirring.

[0462] 4. Apply high shear

[0463] 5. Grind the mixture until the particle size is less than 5 micrometers (D90 < 5 micrometers).

[0464] 6. Calculate the grinding factor.

[0465] 7. If necessary, adjust the pH to 6-7 using concentrated NaOH / HCl solution.

[0466] 8. Seal the formulation by adding Silcolapse 432, 2% xanthan gum solution, Proxel GXL and the remaining water while stirring.

[0467] Example 13: Fluorouracil 57.9% + Tergitol 15-S-7 + Hostapaht 1306 + BreakThru S-240 + Tween 20 + PolyAgroA

[0468]

[0469] Production method:

[0470] 1. Add Van Gel B to the water and apply high shear.

[0471] 2. Add Tergitol 15-S-7, Hostaphat 1306, BreakThru S-240, Tween 20, half of Silcolapse 432, PolyAgroA, propylene glycol and apply high shear.

[0472] 3. Add fluorourea gradually while stirring.

[0473] 4. Apply high shear

[0474] 5. Grind the mixture until the particle size is less than 5 micrometers (D90 < 5 micrometers).

[0475] 6. Calculate the grinding factor.

[0476] 7. If necessary, adjust the pH to 6-7 using concentrated NaOH / HCl solution.

[0477] 8. Seal the formulation by adding Silcolapse 432, 2% xanthan gum solution, Proxel GXL and the remaining water while stirring, and optionally leave a 5% gap in the water addition for the next step.

[0478] 9. Optionally, add 5% of the adjuvant by applying high shear.

[0479] Examples 1-13 are summarized in Table 1:

[0480]

[0481]

[0482] Examples of EC formulations as excipients:

[0483] Example 14:

[0484]

[0485] Example 15:

[0486]

[0487] Example 16:

[0488]

[0489] Example 17:

[0490]

[0491] Example 18:

[0492]

[0493] Example 19:

[0494]

[0495] Example 20:

[0496]

[0497] Example 21:

[0498]

[0499] Examples of SC formulations containing the excipient EC:

[0500] Example 22:

[0501] Phase 1: SC preparation (68%)

[0502] 1. Place the materials in the table below into a container and mix until a homogeneous solution is obtained.

[0503]

[0504] 2. Grind the mixture to obtain the desired particle size distribution (D90 < 5 microns).

[0505] 3. pH adjustment (using NaOH solution)

[0506] Phase 2: EC preparation (10%)

[0507] Mix the following materials to obtain a clear solution.

[0508]

[0509] Phase 3: Final (22%)

[0510] 1. Add the oil phase (10%) to the milling mixture from stage 1.

[0511] 2. Apply high shear

[0512] 3. Add the following materials to the container and mix to obtain a homogeneous suspension.

[0513]

[0514] Example 23: Fluorouracil formulations mixed with excipients targeting Spodoptera frugiperda Assessment of larvae.

[0515] Insect

[0516] Collected in June 2021 from a cornfield near Negev (located in the northern Negev Desert, near the city of Ashkelon). Spodoptera frugiperda Field strains were fed under standard feeding conditions of 27°C, 55% RH and 14 h photoperiod with a mixture of corn-pollen and premixed diet (Ward's Stonefly Heliothis Diet, USA).

[0517] Insecticide

[0518] The following compares standard Rimon (fluorourea) 100 EC with Rimon Supra 100 SC and other formulations containing excipients:

[0519]

[0520] Bioassay :

[0521] Corn leaves were immersed in the aqueous solution of the preparation or in water as a control. After immersion for 15 seconds, the corn leaves were allowed to air dry for 2 hours. Then, fall armyworm larvae (third instar, 8–10 mm) were reared on the treated corn leaves in a controlled growth chamber (27 ± 2°C and 50% RH, photoperiod 14:10 h light:dark) placed in Petri dishes; filter paper was also added to the dishes (to avoid excessive moisture). For each concentration, 10 larvae were tested, and the experiment was repeated at least three times separately.

[0522] Compared with the control, the larval mortality rate and the larval weight gain (LWG) determined five days after exposure to the preparation were compared.

[0523] Results

[0524]

Claims

1. A stable liquid agricultural chemical composition comprising: (a) Fluorouracil; (b) A system containing at least two wetting agents; and (c) A system of at least two dispersants.

2. The composition of claim 1, wherein, The wetting agent is selected from silicone-based surfactants and alkyl polyalkylene glycol ether phosphoric acid.

3. The composition of claim 2, wherein, The silicone-based surfactant is selected from Silwet. ® L77, Silwet 806, BREAK-THRU ® S 240 and BREAK-THRU ® S 233, Where n = 1-4, y = 3-10, z = 0-5, and R is an alkyl group or H or OH having 1-4 carbon atoms.

4. The composition of claim 3, wherein, The silicone-based surfactant is BreakThru S-240.

5. The composition of claim 2, wherein, The alkyl polyalkylene glycol ether phosphate form is selected from Hostaphat. ® 1306 (alkyl polyethylene glycol ether phosphate mono / diester (50 / 50), acid form), Hostaphat ® CC 100 (Cetyl phosphate, acid form, mono / diester approximately 98%), SERVOXYL VPDZ 3 / 100 (Trinyl polyethylene glycol ether (3EO) phosphate), PROTE-PON P-TD-06-Z (alkyl ether phosphate), LUBRHOPHOS LP 700 (phosphate with aromatic base), RHODAFAC BG 510 (phosphate with aliphatic base), DEMALIX C (alkyl phosphate in aqueous / organic media), SANDOCLEAN SKBB (alkyl phosphate), PROTE-PON TD-09-K30 (alkyl ether potassium phosphate), PAE147 (phosphorylated alcohol ethoxylate), LIBRAPHOS AD (sodium salt of Libraphos EP 120), NIKKOL DDP-2 (diPOE(2) alkyl ether phosphate; free acid form), MARLOPHOR NP7-ACID (nonylphenol polyethylene glycol ether phosphate), MARLOWET 5301 (coconut oil polyethylene glycol ether phosphate), ATLAS G-2203 (potassium salt of phosphate), FOSFODET1214 N / 16 (ethoxylated fatty alcohol phosphate).

6. The composition of claim 5, wherein, The alkyl polyalkylene glycol ether phosphate form is Hostaphart. ® 1306.

7. The composition of claim 2, wherein, The wetting agent system further includes alcohol ethoxylates.

8. The composition of claim 7, wherein, The alcohol ethoxylate is selected from Tergitol 15-S-7, Tergitol 15-S-9, Tergitol 15-S-12, and those having the following structure. The compound, where m + n = 15 and x is the number of repeating ethoxylate (EO) units.

9. The composition of claim 8, wherein, The alcohol ethoxylate is Tergitol 15-S-7.

10. The composition according to claim 1 or 2, wherein, The dispersant system comprises a polyelectrolyte comb copolymer.

11. The composition of claim 10, wherein, The polyelectrolyte comb copolymer is PolyAgroA.

12. The composition of claim 10 or 11, further comprising a dispersant selected from polyelectrolyte comb copolymers, EO-PO copolymers, polymethyl methacrylate-polyethylene glycol graft copolymers, tristyrylphenol ethoxylate in phosphate form, and polyoxyethylene sorbitol ester.

13. The composition of claim 12, wherein, The EO-PO copolymers are selected from Ethylan NS 500 (polyalkoxylated butyl ether), Antarox B / 848 (ethylene oxide, methyl-, and polymers with ethylene oxide), Ultraic 5000 HM (ethoxylated and propoxylated alcohols), Toximul 8350 (polyethylene glycol-polypropylene glycol monobutyl ether), Tergitol XD (ethylene oxide / propylene oxide block copolymer), Atlas G-5000-SO-(CQ) (ethylene oxide, 2-methyl-, and polymers with ethylene oxide, monobutyl ether), Atlas G-5002L-LQ-(CQ) (ethylene oxide, monobutyl ether), SYNERGEN 848 (block polyoxyalkylene oxide), Ethylan 992, and Ultraric 5000 HM (EU source) (polyethylene glycol-polypropylene glycol monobutyl ether).

14. The composition of claim 12, wherein, The polymethyl methacrylate-polyethylene glycol graft copolymer is selected from Atlox 4913, STEP-FLOW 3000 and STEP-FLOW 4000.

15. The composition of claim 12, wherein, The tristyrylphenol ethoxylate phosphate form is selected from Soprophor 3D33, Soprophor FL, Surfom 1322 SC, Agnique PE TSP 16T and Dispersogen TP 160T.

16. The composition of claim 12, wherein, The polyoxyethylene sorbitol ester is selected from Tween 20, Hostacerin L 20, Hostacerin L 20 SG Vita, Alkamuls T 20, Emulsogen 4156, and AlkestTW 20.

17. The composition according to any one of claims 1-16, wherein, The composition further comprises at least one agriculturally acceptable additive.

18. The composition of claim 17, wherein, The at least one additive is selected from carriers, defoamers, antifreeze agents, stabilizers, preservatives, thickeners, auxiliary agents, or combinations thereof.

19. The composition of claim 18, wherein, The carrier is an aqueous carrier.

20. The composition of claim 19, wherein, The composition is a suspension concentrate (SC) or a suspension emulsion (SE).

21. The composition according to any one of claims 1-20, wherein, The amount of the fluorourea is 35-60% w / w based on the total weight of the composition.

22. The composition according to any one of claims 1-21, wherein, The amount of the wetting agent system is between 1.5% and 10% w / w based on the total weight of the composition.

23. The composition according to any one of claims 1-22, wherein, The amount of the dispersant system is between 2-12% w / w based on the total weight of the composition.

24. The composition according to any one of claims 1-23, wherein, The pH of the composition is between 6 and 8.

25. Use of at least two wetting agents and at least two dispersants for increasing the stability of a liquid composition containing fluorourea.

26. The use as described in claim 25, wherein, The amount of the fluorourea is 35-60% w / w based on the total weight of the composition.

27. The use as described in claim 25 or 26, wherein, The wetting agent is selected from silicone-based surfactants and alkyl polyalkylene glycol ether phosphate acids.

28. The use as described in claim 27, wherein, The silicone-based surfactant is selected from Silwet. ® L77, Silwet 806, BREAK-THRU ® S 240 and BREAK-THRU ® S 233.

29. The use as described in claim 28, wherein, The silicone-based surfactant is BreakThru S-240.

30. The use as described in claim 27, wherein, The alkyl polyalkylene glycol ether phosphate form is selected from Hostaphat. ® 1306 (alkyl polyethylene glycol ether phosphate mono / diester (50 / 50), acid form), Hostaphat ® CC 100 (Cetyl phosphate, acid form, mono / diester approximately 98%), SERVOXYL VPDZ 3 / 100 (Trinyl polyethylene glycol ether (3EO) phosphate), PROTE-PON P-TD-06-Z (alkyl ether phosphate), LUBRHOPHOS LP 700 (phosphate with aromatic base), RHODAFAC BG 510 (phosphate with aliphatic base), DEMALIX C (alkyl phosphate in aqueous / organic media), SANDOCLEAN SKBB (alkyl phosphate), PROTE-PON TD-09-K30 (alkyl ether potassium phosphate), PAE147 (phosphorylated alcohol ethoxylate), LIBRAPHOS AD (sodium salt of Libraphos EP 120), NIKKOL DDP-2 (diPOE(2) alkyl ether phosphate; free acid form), MARLOPHOR NP7-ACID (nonylphenol polyethylene glycol ether phosphate), MARLOWET 5301 (coconut oil polyethylene glycol ether phosphate), ATLAS G-2203 (potassium salt of phosphate), FOSFODET1214 N / 16 (ethoxylated fatty alcohol phosphate).

31. The use as described in claim 30, wherein, The alkyl polyalkylene glycol ether phosphate form is Hostaphart. ® 1306.

32. The use as described in claim 27, further comprising an alcohol ethoxylate.

33. The use as described in claim 32, wherein, The alcohol ethoxylates are selected from Tergitol 15-S-7, Tergitol 15-S-9 and Tergitol 15-S-12.

34. The use as described in claim 33, wherein, The alcohol ethoxylate is Tergitol 15-S-7.

35. The use as described in claim 25 or 26, wherein, The dispersant comprises a polyelectrolyte comb copolymer.

36. The use as described in claim 35, wherein, The polyelectrolyte comb copolymer is PolyAgroA.

37. The use as described in claim 35 or 36, further comprising a dispersant selected from polyelectrolyte comb copolymers, EO-PO copolymers, polymethyl methacrylate-polyethylene glycol graft copolymers, tristyrylphenol ethoxylate in phosphate form, and polyoxyethylene sorbitol esters.

38. The composition of claim 37, wherein, The EO-PO copolymers are selected from Ethylan NS 500 (polyalkoxylated butyl ether), Antarox B / 848 (ethylene oxide, methyl-, and polymers with ethylene oxide), Ultraic 5000 HM (ethoxylated and propoxylated alcohols), Toximul 8350 (polyethylene glycol-polypropylene glycol monobutyl ether), Tergitol XD (ethylene oxide / propylene oxide block copolymer), Atlas G-5000-SO-(CQ) (ethylene oxide, 2-methyl-, and polymers with ethylene oxide, monobutyl ether), Atlas G-5002L-LQ-(CQ) (ethylene oxide, monobutyl ether), SYNERGEN 848 (block polyoxyalkylene oxide), Ethylan 992, and Ultraric 5000 HM (EU source) (polyethylene glycol-polypropylene glycol monobutyl ether).

39. The composition of claim 37, wherein, The polymethyl methacrylate-polyethylene glycol graft copolymer is selected from Atlox 4913, STEP-FLOW 3000 and STEP-FLOW 4000.

40. The composition of claim 37, wherein, The tristyrylphenol ethoxylate phosphate form is selected from Soprophor 3D33, Soprophor FL, Surfom 1322 SC, Agnique PE TSP 16T and Dispersogen TP 160T.

41. The composition of claim 37, wherein, The polyoxyethylene sorbitol ester is selected from Tween 20, Hostacerin L 20, Hostacerin L 20 SG Vita, Alkamuls T 20, Emulsogen 4156, and AlkestTW 20.

42. The use as described in any one of claims 25-41, wherein, The liquid composition is an aqueous composition.

43. The use as described in claim 42, wherein, The aqueous composition is a suspension concentrate (SC) or a suspension emulsion (SE).

44. The use as described in any one of claims 20-33, wherein, The amount of the wetting agent system is between 1.5% and 10% w / w based on the total weight of the composition.

45. The use as described in any one of claims 20-34, wherein, The amount of the dispersant system is between 2-12% w / w based on the total weight of the composition.

46. ​​Use of the composition according to any one of claims 1-24 for treating plants.

47. A method for treating plants, the method comprising (1) obtaining a composition as described in any one of claims 1-24, and (2) contacting the plant with an effective amount of the composition.

48. A method for preparing a composition according to any one of claims 1-24, the method comprising mixing a wetting agent, a dispersant, a fluorourea and water.

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