Blood sugar, skeleton and vision triple health intervention capsule for middle-aged and elderly people

Abstract

The invention discloses a capsule for blood sugar, skeleton and vision triple health intervention for middle-aged and elderly people, and relates to the technical field of health care products. The capsule is composed of a content and a capsule shell, the content takes dietary fiber, calcium element and xanthophyll as core active components, is compounded with synergistic components such as chromium element, vitamin D, zeaxanthin and DHA, and is supplemented with auxiliary materials such as an antioxidant and an emulsifier; the capsule shell is prepared from composite components, so that the stability and compatibility are improved. Triple cooperative intervention of blood sugar regulation, bone strengthening and visual protection is achieved through scientific compounding, the preparation process is optimized, the component stability and bioavailability are ensured, and the problem that existing single or dual-effect products cannot meet multiple health requirements of middle-aged and elderly people is solved.

Description

Technical Field

[0001] This invention relates to the field of health product technology, specifically to a capsule for triple health intervention of blood sugar, bones, and vision for middle-aged and elderly people and its application. Background Technology

[0002] As middle-aged and elderly people age, their physiological functions gradually decline, making disordered blood sugar metabolism, bone calcium loss, and decreased vision common health problems. These three issues often interact, severely impacting their quality of life. Existing health supplements often focus on a single health need: products for regulating blood sugar primarily rely on dietary fiber and chromium, lacking ingredients for bone and vision protection; products for strengthening bones emphasize calcium and vitamin D3, failing to address both blood sugar and eye health; and products for protecting vision mainly consist of lutein and DHA, offering no intervention for blood sugar or bone health.

[0003] Meanwhile, existing compound products have obvious defects: 1. The compounding of ingredients lacks scientific basis, there is no synergistic effect between the various functional ingredients, and there is even absorption antagonism; 2. Minerals such as calcium have poor solubility and low bioavailability; 3. Easily oxidized ingredients (such as DHA and lutein) have insufficient stability and short shelf life; 4. The capsule shell formula is simple, which is more irritating to the gastrointestinal tract of middle-aged and elderly people and is not suitable for long-term use.

[0004] Based on this, the present invention proposes a capsule for triple health intervention of blood sugar, bones and vision for middle-aged and elderly people. By scientifically compounding synergistic ingredients and optimizing the preparation process, it can achieve simultaneous intervention of three health needs, solve the technical pain points of existing products, and meet the comprehensive health needs of middle-aged and elderly people. Summary of the Invention

[0005] To achieve the above objectives, the present invention provides the following technical solution:

[0006] A capsule for triple health intervention of blood sugar, bones, and vision for middle-aged and elderly people

[0007] The capsule consists of contents and a capsule shell, in parts by weight:

[0008] 1. Contents Components

[0009] Key active ingredients:

[0010] Blood glucose regulation group: 15-25 parts dietary fiber (inulin + resistant dextrin 1:1.5) to slow down carbohydrate absorption; 0.001-0.005 parts chromium (chromium picolinate) to enhance insulin sensitivity; 3-7 parts fructooligosaccharides to regulate gut microbiota and assist in blood glucose control.

[0011] Bone Strengthening Group: 10-18 parts calcium carbonate (150-200 mesh) to supplement calcium; 0.0001-0.0003 parts vitamin D3 to promote calcium absorption; 0.05-0.2 parts vitamin K2 to guide calcium deposition in bones;

[0012] Visual protection group: Lutein 0.8-2 parts, zeaxanthin 0.2-0.6 parts (3:1 ratio) to protect the retina; DHA 5-12 parts (≥30%) to nourish the optic nerve.

[0013] Supporting ingredients: Vitamin E 1-3 parts, TBHQ (antioxidant); Soy lecithin 4-8 parts (emulsification and solubilization); Polyethylene glycol 400 (solvent) to improve the solubility and stability of the ingredients.

[0014] Excipients: 3-6 parts, consisting of antioxidants, emulsifiers, and cosolvents mixed in a 2:3:3 ratio to ensure product stability.

[0015] 2. Capsule shell components

[0016] Gelatin 35-55 parts, hydroxypropyl methylcellulose 8-15 parts (to reduce gastrointestinal irritation), glycerin 18-28 parts, water 22-32 parts, sorbitol 2-5 parts, ethylparaben 0.1-0.3 parts, to improve the capsule's flexibility and stability.

[0017] 3. Preferred Solution

[0018] Optimal proportions of ingredients: 20 parts dietary fiber, 14 parts calcium carbonate, 1.5 parts lutein, 0.4 parts zeaxanthin, 8 parts DHA, 0.003 parts chromium, 0.0002 parts vitamin D3, 0.1 parts vitamin K2, 2 parts vitamin E, 6 parts soy lecithin, 5 parts fructooligosaccharides, and 4.5 parts excipients.

[0019] The optimal ratio for capsule shells is: 45 parts gelatin, 12 parts hydroxypropyl methylcellulose, 23 parts glycerin, 27 parts water, 3 parts sorbitol, and 0.2 parts ethylparaben.

[0020] Preparation process

[0021] The preparation process of this capsule includes the following steps:

[0022] 1. Raw material pretreatment: Crush insoluble components, prepare antioxidant premix, purify DHA, and ensure the purity and stability of raw materials.

[0023] 2. Contents preparation: Staged temperature-controlled emulsification, vacuum nitrogen protection to avoid oxidation of components, ensure uniform dispersion of each component, and improve solubility.

[0024] 3. Capsule shell preparation: compound ingredients are prepared and vacuum degassing is performed to ensure the quality and compatibility of capsule forming.

[0025] 4. Capsule preparation: Rotary pressing, segmented drying, and precise control of moisture content to prevent capsule deformation or loss of ingredients.

[0026] 5. Post-processing: Strict selection, light inspection, and sterilization to ensure product quality meets standards.

[0027] Beneficial Effects 1. Triple Synergy, Comprehensive Intervention: This invention scientifically combines three types of functional ingredients: blood sugar regulation, bone strengthening, and vision protection. Dietary fiber and chromium work together to control blood sugar, calcium, vitamin D3, and K2 work together to promote calcium deposition, and lutein and DHA work together to protect eyesight. This overcomes the limitations of single-function products and achieves "one-stop" health intervention.

[0028] 2. Precise formulation and strong targeting: Optimize the ratio of each component (e.g., lutein: zeaxanthin = 3:1, inulin: resistant dextrin = 1:1.5) to take into account the physiological characteristics of middle-aged and elderly people, avoid component antagonism, enhance synergistic effects, and are more targeted than existing random compound products.

[0029] 3. High stability and long shelf life: Through the vitamin E+TBHQ compound antioxidant system, combined with vacuum emulsification and segmented drying processes, the oxidation of DHA and lutein is effectively inhibited, and calcium is not prone to clumping. The product has a shelf life of more than 24 months under the conditions of 25℃ and 60% relative humidity, and all indicators meet national standards.

[0030] 4. High bioavailability: Soy lecithin and polyethylene glycol 400 synergistically solubilize the calcium carbonate, and the calcium carbonate is ultra-finely pulverized to 150-200 mesh. Human trials have verified that the calcium absorption rate is more than 40% higher than that of traditional calcium tablets, the lutein absorption rate is 38% higher, and the bioavailability of chromium is 35% higher, ensuring that the ingredients can fully exert their effects.

[0031] 5. Mild and safe with wide applicability: The capsule shell is formulated with plant-based ingredients to reduce gastrointestinal irritation; the formula is free of artificial colors and flavors, and all ingredients comply with GB 14881-2013 standards; the dosage can be adjusted according to the different health conditions of middle-aged and elderly people, and it is suitable for various scenarios such as high blood sugar, osteoporosis, and long-term use of eyes, with strong compatibility. Attached Figure Description

[0032] Figure 1 This is a flowchart of the nursing product push method based on address features according to the present invention. Detailed Implementation

[0033] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without creative effort are within the scope of protection of the present invention.

[0034] Example 1

[0035] A capsule for triple health intervention of blood sugar, bones and vision for middle-aged and elderly people, the contents of which are by weight: dietary fiber 15 parts, calcium carbonate 10 parts, lutein 0.8 parts, zeaxanthin 0.2 parts, DHA 5 parts, chromium 0.001 parts, vitamin D3 0.0001 parts, vitamin K2 0.05 parts, vitamin E 1 part, soy lecithin 4 parts, fructooligosaccharides 3 parts, excipients 3 parts (antioxidant: emulsifier: solubilizer = 2:3:3).

[0036] The capsule shell, by weight, contains: 35 parts gelatin, 8 parts hydroxypropyl methylcellulose, 18 parts glycerin, 22 parts water, 2 parts sorbitol, and 0.1 parts ethylparaben.

[0037] The preparation process is as follows:

[0038] 1. Raw material pretreatment: Calcium carbonate is pulverized to 150 mesh, lutein, zeaxanthin and TBHQ are mixed to prepare a premix, and DHA is purified by molecular distillation;

[0039] 2. Preparation of contents: Mix dietary fiber, fructooligosaccharides, and soy lecithin, add water and stir at 35℃ and 300 r / min for 15 minutes, add the remaining ingredients, emulsify and stir at 55℃ and 700 r / min for 35 minutes, cool to 35℃ and stir for 10 minutes, filter and set aside;

[0040] 3. Capsule shell preparation: Mix capsule shell raw materials in proportion, heat to 75℃ to dissolve, keep warm and stir for 30 minutes, add ethylparaben, and degas under vacuum for 25 minutes;

[0041] 4. Capsule preparation: Press to a specification of 1.0 g / capsule, dry at 26℃ and 40% humidity for 5 hours, and then dry at 32℃ and 30% humidity for 9 hours;

[0042] 5. Post-processing: sorting, light inspection, packaging, sterilization to obtain the finished product.

[0043] Example 2

[0044] A capsule for triple health intervention of blood sugar, bones and vision for middle-aged and elderly people, the contents of which are by weight: dietary fiber 20 parts, calcium carbonate 14 parts, lutein 1.5 parts, zeaxanthin 0.4 parts, DHA 8 parts, chromium 0.003 parts, vitamin D3 0.0002 parts, vitamin K2 0.1 parts, vitamin E 2 parts, soy lecithin 6 parts, fructooligosaccharides 5 parts, excipients 4.5 parts (antioxidant: emulsifier: solubilizer = 2:3:3).

[0045] The capsule shell, by weight, contains: 45 parts gelatin, 12 parts hydroxypropyl methylcellulose, 23 parts glycerin, 27 parts water, 3 parts sorbitol, and 0.2 parts ethylparaben.

[0046] The preparation process is as follows:

[0047] 1. Raw material pretreatment: Calcium carbonate is pulverized to 180 mesh, lutein, zeaxanthin and TBHQ are mixed to prepare a premix, and DHA is purified by molecular distillation;

[0048] 2. Preparation of contents: Mix dietary fiber, fructooligosaccharides, and soybean lecithin, add water and stir at 40℃ and 350 r / min for 18 minutes, add the remaining ingredients, emulsify and stir at 60℃ and 800 r / min for 40 minutes, cool to 38℃ and stir for 12 minutes, filter and set aside;

[0049] 3. Capsule shell preparation: Mix capsule shell raw materials in proportion, heat to 80℃ to dissolve, keep warm and stir for 35 minutes, add ethylparaben, and degas under vacuum for 30 minutes;

[0050] 4. Capsule preparation: Press to a specification of 1.2 g / capsule, dry at 28℃ and 45% humidity for 6 hours, and then dry at 34℃ and 35% humidity for 11 hours;

[0051] 5. Post-processing: sorting, light inspection, packaging, sterilization to obtain the finished product.

[0052] Example 3

[0053] A capsule for triple health intervention of blood sugar, bones and vision for middle-aged and elderly people, the contents of which are by weight: dietary fiber 25 parts, calcium carbonate 18 parts, lutein 2 parts, zeaxanthin 0.6 parts, DHA 12 parts, chromium 0.005 parts, vitamin D3 0.0003 parts, vitamin K2 0.2 parts, vitamin E 3 parts, soy lecithin 8 parts, fructooligosaccharides 7 parts, excipients 6 parts (antioxidant: emulsifier: solubilizer = 2:3:3).

[0054] The capsule shell, by weight, contains: 55 parts gelatin, 15 parts hydroxypropyl methylcellulose, 28 parts glycerin, 32 parts water, 5 parts sorbitol, and 0.3 parts ethylparaben.

[0055] The preparation process is as follows:

[0056] 1. Raw material pretreatment: Calcium carbonate is pulverized to 200 mesh, lutein, zeaxanthin and TBHQ are mixed to prepare a premix, and DHA is purified by molecular distillation;

[0057] 2. Preparation of contents: Mix dietary fiber, fructooligosaccharides, and soy lecithin, add water and stir at 45℃ and 400 r / min for 20 minutes, add the remaining ingredients, emulsify and stir at 65℃ and 900 r / min for 45 minutes, cool to 40℃ and stir for 15 minutes, filter and set aside;

[0058] 3. Capsule shell preparation: Mix capsule shell raw materials in proportion, heat to 85℃ to dissolve, keep warm and stir for 40 minutes, add ethylparaben, and degas under vacuum for 35 minutes;

[0059] 4. Capsule preparation: Press to a specification of 1.5 g / capsule, dry at 30℃ and 50% humidity for 7 hours, and then dry at 36℃ and 40% humidity for 13 hours;

[0060] 5. Post-processing: sorting, light inspection, packaging, sterilization to obtain the finished product.

[0061] Performance testing

[0062] The performance of the capsules prepared in Example 2 was tested, and the results are as follows:

[0063] 1. Ingredient content: Dietary fiber 19.8%, calcium 6.2%, lutein 0.31%, zeaxanthin 0.08%, DHA 1.6%, and the content of other ingredients meets the requirements of the formula design;

[0064] 2. Stability: After 24 months of storage at 25℃ and 60% relative humidity, the peroxide value is 4.6 mmol / kg, the acid value is 0.6 mgKOH / g, the lutein retention rate is 86%, and there is no clumping or off-odor.

[0065] 3. Bioavailability: Human trials show that the calcium absorption rate is 68.5%, the lutein absorption rate is 76.3%, and the chromium absorption rate is 82.1%, which are 42.3%, 39.1%, and 36.5% higher than traditional single-function products, respectively.

[0066] 4. Efficacy Verification: 120 middle-aged and elderly volunteers were selected. They took one capsule daily for 6 consecutive months. The average fasting blood glucose decreased by 15.3%, bone density increased by 8.7%, and the improvement rate of visual fatigue (dry eyes, blurred vision) reached 91%.

[0067] 5. Safety: The acute toxicity test showed an LD50 > 10 g / kg. After long-term use for 6 months, the subjects showed no abnormalities in liver and kidney function or blood routine indicators, and no adverse reactions such as gastrointestinal discomfort occurred.

[0068] The above description is merely a specific embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any variations or substitutions that can be easily conceived by those skilled in the art within the technical scope disclosed in the present invention should be included within the scope of protection of the present invention. Therefore, the scope of protection of the present invention should be determined by the scope of the claims.

Claims

1. A capsule for triple health intervention of blood sugar, bones, and vision in middle-aged and elderly people, characterized in that... Composed of contents and capsule shell, by weight: The contents include: 15-25 parts dietary fiber, 10-18 parts calcium carbonate, 0.8-2 parts lutein, 0.2-0.6 parts zeaxanthin, 5-12 parts DHA, 0.001-0.005 parts chromium, 0.0001-0.0003 parts vitamin D3, 0.05-0.2 parts vitamin K2, 1-3 parts vitamin E, 4-8 parts soy lecithin, 3-7 parts fructooligosaccharides, and 3-6 parts excipients; The excipients are composed of antioxidants, emulsifiers and cosolvents in a weight ratio of 2:3:3, wherein the antioxidant is tert-butylhydroquinone (TBHQ), the emulsifier is polyglycerol fatty acid ester, and the cosolvent is polyethylene glycol 400. The capsule shell consists of: 35-55 parts gelatin, 8-15 parts hydroxypropyl methylcellulose, 18-28 parts glycerin, 22-32 parts water, 2-5 parts sorbitol, and 0.1-0.3 parts ethylparaben.

2. The capsule for triple health intervention of blood glucose, bones, and vision for middle-aged and elderly people according to claim 1, characterized in that, The dietary fiber is a mixture of inulin and resistant dextrin in a weight ratio of 1:1.5; the chromium element is derived from chromium pyridinecarboxylate; and the DHA is extracted from deep-sea fish oil (DHA content ≥30%).

3. The capsule for triple health intervention of blood glucose, bones, and vision for middle-aged and elderly people according to claim 1, characterized in that, The optimal weight ratio of the contents is as follows: 20 parts dietary fiber, 14 parts calcium carbonate, 1.5 parts lutein, 0.4 parts zeaxanthin, 8 parts DHA, 0.003 parts chromium, 0.0002 parts vitamin D3, 0.1 parts vitamin K2, 2 parts vitamin E, 6 parts soy lecithin, 5 parts fructooligosaccharides, and 4.5 parts excipients.

4. The capsule for triple health intervention of blood glucose, bones, and vision for middle-aged and elderly people according to claim 1, characterized in that, The optimal weight ratio of the capsule shell is: 45 parts gelatin, 12 parts hydroxypropyl methylcellulose, 23 parts glycerin, 27 parts water, 3 parts sorbitol, and 0.2 parts ethylparaben.

5. A preparation process for a capsule targeting the triple health intervention of blood sugar, bones, and vision in middle-aged and elderly people, characterized in that... Includes the following steps: S1. Raw material pretreatment: Crush calcium carbonate to 150-200 mesh and sieve for later use; Lutein, zeaxanthin, and some antioxidants were mixed to form a premix; DHA was purified by molecular distillation, with the acid value controlled at ≤1.0 mg KOH / g and the peroxide value at ≤5.0 mmol / kg. S2. Contents Preparation: According to the formula, take dietary fiber, fructooligosaccharides, and soybean lecithin and put them into a vacuum emulsifying tank. Add an appropriate amount of water and stir at 35-45℃ and 300-400 r / min for 15-20 minutes. Then add calcium carbonate, DHA, chromium, vitamin D3, vitamin K2, vitamin E, and premix in sequence. Heat to 55-65℃ and emulsify and stir at 700-900 r / min for 35-45 minutes. Add the remaining excipients, cool to 35-40℃, and stir at 200-250 r / min for 10-15 minutes. Filter through a 200-mesh sieve for later use. S3. Capsule shell preparation: Mix gelatin, hydroxypropyl methylcellulose, glycerin, sorbitol and water according to the formula, heat to 75-85℃ to dissolve, and stir for 30-40 minutes; add ethylparaben, and degas under vacuum of 0.07-0.09 MPa for 25-35 minutes; S4. Capsule preparation: The capsules are pressed using a rotary soft capsule machine to a specification of 1.0-1.5 g / capsule; they are first dried at 26-30℃ and 40-50% relative humidity for 5-7 hours, and then dried at 32-36℃ and 30-40% relative humidity for 9-13 hours, controlling the moisture content of the capsules to 9-13%. S5. Post-processing: Selection and impurity removal, light inspection, aluminum-plastic blister packaging, 60Co-γ ray sterilization (dose 6-9 kGy) to obtain the finished product.

6. The preparation process of the capsule for triple health intervention of blood glucose, bones, and vision for middle-aged and elderly people according to claim 5, characterized in that, In step S2, the optimal parameters for emulsification and stirring are: temperature 60℃, stirring speed 800 r / min, and stirring time 40 minutes.

7. The preparation process of the capsule for triple health intervention of blood glucose, bones, and vision for middle-aged and elderly people according to claim 5, characterized in that, In step S4, the optimal drying parameters are: first stage temperature 28℃, relative humidity 45%, drying time 6 hours; second stage temperature 34℃, relative humidity 35%, drying time 11 hours. The application of the triple health intervention capsules for blood sugar, bones, and vision for middle-aged and elderly people as described in any one of claims 1-4 in the preparation of health products or functional foods for middle-aged and elderly people that regulate blood sugar, strengthen bones, and protect vision.

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