Multi-effect acne-removing composition containing medicinal phellinus igniarius extract and application of multi-effect acne-removing composition

Abstract

The invention relates to the technical field of cosmetics, and particularly discloses a multi-effect acne-removing composition containing a medicinal phellinus igniarius extract and application of the multi-effect acne-removing composition. By compounding the phellinus igniarius extract, the calendula fermentation extract, the kadsura longepedunculata extract and the trifolium pretense extract, the composition is used for improving and preventing'mood acnes' caused or aggravated by mood fluctuations such as pressure, anxiety and depression, and has certain effects of fading acne marks and brightening skin color. The multi-effect acne-removing composition is applied to preparation of cosmetics, and the effects of inhibiting mood acnes, repairing and fading acne marks and brightening the skin color of the cosmetics are achieved.

Description

Technical Field

[0001] This application relates to the field of cosmetic technology, and in particular to a multi-effect acne-removing composition containing medicinal Fomitopsis pinnatifida extract and its application. Background Technology

[0002] Emotional acne is a unique skin condition mediated by psychological and emotional factors through the brain-skin axis, fundamentally different from acne vulgaris in both clinical manifestations and pathogenesis. This condition has distinct clinical characteristics: In terms of location, it commonly occurs on the lower face, such as the chin and perilip area, which are abnormally sensitive to stress hormones (e.g., cortisol), and in severe cases, it can spread to the neck; morphologically, the lesions mainly manifest as clusters of deep-seated, red, swollen, and tender inflammatory papules that mature slowly and easily leave stubborn acne scars after resolution. It is also commonly accompanied by problems such as "oily outside, dry inside," redness, sensitivity, and slow healing due to impaired skin barrier function. Its occurrence is clearly related to emotional fluctuations, erupting after short-term acute stress or worsening with long-term chronic stress. Furthermore, emotional acne often responds poorly to or even causes intolerance to conventional acne-fighting ingredients such as salicylic acid and retinoic acid. The pathophysiological root of all this lies in the unique "neurogenic inflammation" response triggered by emotional stress—the release of neuropeptides such as substance P from sensory nerve endings directly leads to severe inflammation, and together with abnormally elevated cortisol, it causes hypersecretion of sebum, skin microecological disorder, and inhibition of barrier repair ability, forming a complex vicious cycle.

[0003] Currently, mainstream acne treatments reveal inherent limitations and flaws when faced with the complexities of emotional acne. Existing technologies primarily rely on single mechanisms of action, such as the exfoliating effect of salicylic acid, the antibacterial effect of benzoyl peroxide, and the keratinization regulation of retinoic acid. These ingredients were not designed with the core role of the brain-skin axis in mind. Therefore, while they can improve follicular blockage and excessive microbial proliferation to some extent, they struggle to effectively inhibit the neurogenic inflammatory pathway driven by substance P, a hallmark and core of emotional acne. More seriously, these ingredients, especially retinoic acid and benzoyl peroxide, are inherently irritating to the skin. When applied to skin already weakened by emotional stress, they not only fail to address deep redness and pain but also easily further damage the skin barrier, exacerbating dryness, flaking, and sensitivity, leading to a vicious cycle of "the more you treat, the more sensitive you become." In addition, existing treatments generally neglect the high sensitivity of the sebaceous glands in the mandibular region to stress hormones, lack targeted source regulation, and fail to provide the barrier repair function urgently needed by emotional acne-prone skin, resulting in less effective treatment and a high recurrence rate. Summary of the Invention

[0004] The purpose of this application is to overcome the shortcomings of the prior art and provide a multi-effect acne-removing composition containing medicinal Fomitopsis extract, which has a multi-stage and multi-pathway synergistic effect from "preventing the cause" to "intervention process" and "repairing traces", as well as its application.

[0005] To achieve the above objectives, the technical solution adopted in this application is as follows: This application provides a multi-effect acne-removing composition containing medicinal Fomitopsis pinnatifida extract, the multi-effect acne-removing composition comprising the following components in parts by weight: 0.05-5 parts of medicinal Fomitopsis pilosula extract, 0.05-3 parts of Calendula officinalis fermented extract, 0.01-1 parts of Schisandra chinensis extract and 0.05-2 parts of red clover extract; The calendula fermented extract is a calendula extract using bumblebee stamina yeast. Starmerella bombicola The product obtained from fermentation.

[0006] In the technical solution of this application, a compound of the above-mentioned mass fractions of *Polyporus medica* extract, calendula fermented extract, *Schisandra chinensis* extract, and red clover extract is used to improve and prevent "emotional acne" caused or aggravated by emotional fluctuations (such as stress, anxiety, depression, etc.), and also has a certain effect of fading acne scars and brightening skin tone. The multi-effect acne-removing composition containing *Polyporus medica* extract provided by this application achieves a multi-stage, multi-pathway synergistic effect from "preventing triggers" to "intervening in the process" to "repairing scars," thereby achieving the effects of multi-effect inhibition of emotional acne, repair, fading acne scars, and brightening skin tone.

[0007] Among them, the combination of medicinal Ferula fuciformis extract and Calendula officinalis fermented extract achieves a strong anti-Propionibacterium acnes effect. It can not only directly inhibit Propionibacterium acnes and regulate 5α-reductase activity to control sebum secretion, but also the Calendula officinalis fermented extract has better anti-inflammatory ability. The sophorolipids produced by its metabolism can destroy the biofilm formed by Propionibacterium acnes, so that the antibacterial components of Ferula fuciformis can act more deeply on the pathogens.

[0008] The combination of medicinal Ferula scabra extract, Calendula officinalis fermented extract, and Schisandra chinensis extract has a synergistic anti-inflammatory effect: the lignans in Schisandra chinensis extract block the inflammatory cascade response caused by bacterial infection from the upstream by inhibiting key inflammatory signaling pathways such as NF-κB, complementing the anti-inflammatory effect of Calendula officinalis fermented extract, and together with Ferula scabra, reduce the damage of inflammation to the skin.

[0009] The synergistic effect of red clover extract and schisandra chinensis extract in reducing emotional stress is due to their combined action on the "skin-nerve-endocrine" axis, achieving multi-level regulation from exogenous soothing to endogenous stabilization.

[0010] As a preferred embodiment of the multi-effect acne-removing composition containing medicinal Fomitopsis pinnatifida extract described in this application, the multi-effect acne-removing composition comprises the following components in parts by weight: 1.5-3 parts of medicinal Fomitopsis pilosula extract, 0.1-0.5 parts of Calendula officinalis fermented extract, 0.05-0.2 parts of Schisandra chinensis extract and 0.5-1 parts of red clover extract.

[0011] In this application, a medicinal acne-removing composition is made with Phytotrichum candida extract. The Phytotrichum candida extract, through its rich triterpenoid compounds, significantly inhibits 5α-reductase activity, blocking the conversion of testosterone to dihydrotestosterone at the source. It directly targets the problem of excessive sebum secretion caused by stress hormones, thereby effectively reducing oil production. This regulatory effect not only helps to tighten enlarged pores and improve the oily texture of oily skin, but also fundamentally relieves the follicle blockage caused by excess sebum, creating a good skin environment for subsequent ingredients to work.

[0012] This application incorporates calendula fermented extract into its multi-effect acne-removing composition. The large-molecule anti-inflammatory polysaccharides and flavonoids in calendula are degraded into smaller molecular fragments that more easily penetrate the skin barrier, significantly enhancing its ability to soothe redness and swelling and inhibit the release of inflammatory factors. Simultaneously, the sophorolipids in the calendula fermented extract, as a top-tier biosurfactant, greatly improve the transdermal absorption rate of the soothing and anti-inflammatory components of calendula. It also precisely regulates the skin microecology, inhibits the excessive proliferation of Propionibacterium acnes, and strengthens the damaged skin barrier from within. For stress-related acne, this means it can not only quickly extinguish the "fire" caused by neurogenic inflammation but also build a more resilient and stable skin environment by repairing the barrier and regulating the microbiota.

[0013] Schisandra chinensis extract, with its rich lignans, exerts an adaptogenic regulatory effect, balancing the skin's abnormal response to emotional stress. These active substances directly intervene in the neurogenic inflammatory process induced by neuropeptides such as substance P by inhibiting the activation of key inflammatory signaling pathways such as NF-κB, effectively reducing acne symptoms such as redness and tenderness. At the same time, its powerful antioxidant capacity can neutralize excess free radicals caused by stress, blocking the chain reaction of emotional stress on the skin from multiple levels.

[0014] The isoflavones in red clover extract have a mild phytoestrogen-like effect, which can regulate hormonal imbalances caused by emotional fluctuations, especially balancing the abnormal stimulation of sebaceous glands by stress hormones such as cortisol. By specifically inhibiting the TLR-2 / NF-κB inflammatory signaling pathway, it significantly reduces the production and release of key pro-inflammatory factors such as IL-8 and IL-6, while enhancing the integrity of the skin barrier, building a protective system against external stimuli, and comprehensively improving the inflammatory state and sensitive constitution of emotional acne.

[0015] This application uses medicinal Fertilizer Extract, Calendula Fermentata Extract, Schisandra chinensis Extract and Red Clover Extract within the above-mentioned preferred mass range, which can better improve and prevent "emotional acne" caused or aggravated by emotional fluctuations such as stress, anxiety, and depression, and also has better effects in fading acne marks and brightening skin tone.

[0016] As a preferred embodiment of the multi-effect acne-removing composition containing medicinal fusiforme extract described in this application, the sum of the mass of the medicinal fusiforme extract and the calendula fermented extract accounts for 65% to 75% of the total mass of the multi-effect acne-removing composition.

[0017] When the combined mass of medicinal Ferula meliflora extract and Calendula officinalis fermented extract in the multi-effect acne treatment composition is within the above range, it can better improve and prevent "emotional acne" caused or aggravated by emotional fluctuations such as stress, anxiety, and depression.

[0018] For example, based on the total mass of the multi-effect acne-removing composition, the sum of the masses of the medicinal Ferula meliflora extract and the calendula fermented extract can be any point value or any two points between 65% and 75%, such as 65%, 66%, 67%, 68%, 69%, 70%, 71%, 72%, 73%, 74%, and 75%.

[0019] As a preferred embodiment of the multi-effect acne-removing composition containing medicinal Ferula melitica extract described in this application, the method for preparing the calendula fermented extract includes the following steps: S1. Activate the bumblebee yeast to obtain the activated bacterial solution; S2. Crush the dried calendula flowers, mix the crushed calendula flowers with deionized water, and perform hot extraction to obtain the basic calendula flower extract. S3. Inoculate the bacterial culture from step S1 into the calendula basic extract obtained in step S2 for fermentation culture to obtain fermentation broth. Centrifuge the fermentation broth, take the supernatant, filter and sterilize to obtain calendula fermentation extract.

[0020] This application utilizes *Saccharomyces cerevisiae* fermentation to deeply transform calendula, degrading the large molecules of its original active ingredients into smaller fragments such as oligosaccharides and aglycones. This significantly improves transdermal absorption, enhancing its soothing and repairing effects on damaged skin barriers, making it particularly suitable for rebuilding the skin's microecological balance under stress. It also generates fermentation products rich in biosurfactants such as sophorolipids. Sophorolipids, as natural biosurfactants, further promote the penetration of active ingredients, making them especially suitable for "oily on the outside, dry on the inside" skin with a damaged barrier. Sophorolipids possess excellent antibacterial and anti-inflammatory properties, selectively inhibiting *Propionibacterium acnes* by disrupting cell membrane integrity without affecting beneficial bacteria, thus meeting the repair needs of emotional acne microecological imbalances.

[0021] Furthermore, the combination of calendula fermentation extract and medicinal fusiforme extract obtained by the above preparation method can better combat Propionibacterium acnes. In particular, the product obtained by fermenting calendula with bumblebee Saccharomyces cerevisiae not only enhances the anti-inflammatory ability of calendula itself, but the sophorolipids produced by its metabolism can also destroy the biofilm formed by Propionibacterium acnes, allowing the antibacterial components of fusiforme to act more deeply on the pathogens.

[0022] Preferably, in step S1, the bumblebee *Saccharomyces cerevisiae* is dissolved in sterile water, inoculated onto a plate for activation culture, a single colony is selected and inoculated onto a new plate for continued culture, cultured to the late logarithmic growth stage, and the activated bumblebee *Saccharomyces cerevisiae* is picked and dissolved in sterile water to form an activated bacterial solution.

[0023] In some specific embodiments, the plate is a sterile malt extract agar (MEA) plate.

[0024] In step S1, the activation and culturing conditions include: activation temperature of 26-30℃ and culturing time of 24-48h. The conditions for continued culturing include: culturing temperature of 26-30℃, rotation speed of 150-200 rpm, and culturing time of 24-36h.

[0025] As a preferred embodiment of the multi-effect acne-removing composition containing medicinal Fomitopsis pinnatifida extract described in this application, in step S2, the mass-to-volume ratio of pulverized calendula and deionized water is 1g:(10~20)mL.

[0026] As a preferred embodiment of the multi-effect acne-removing composition containing medicinal Fomitopsis pinnatifida extract described in this application, in step S2, the hot extraction temperature is 60~80℃ and the hot extraction time is 1~3h; preferably, the hot extraction temperature is 80℃ and the hot extraction time is 1~3h.

[0027] In the technical solution of this application, the pulverized calendula and deionized water within the above-mentioned mass ratio range, and the above-mentioned hot extraction conditions, can maximize the dissolution of initial components such as polysaccharides and flavonoids in the calendula petals, providing sufficient substrate for subsequent microbial transformation; and the calendula fermentation extract obtained therefrom can better inhibit Propionibacterium acnes.

[0028] In a preferred embodiment of the multi-effect acne-removing composition containing medicinal Fomitopsis pinnatifida extract described in this application, in step S3, the inoculation amount of the bacterial solution is 5-15%; preferably, the inoculation amount of the bacterial solution is 8%.

[0029] In a preferred embodiment of the multi-effect acne-removing composition containing medicinal Fomitopsis pinnatifida extract described in this application, the fermentation culture conditions in step S3 include: The rotation speed is 200~500 rpm, the aeration rate is 1.0~1.5 vvm, the dissolved oxygen level is 20~30%, the temperature is 25~28℃, and the fermentation time is 96~120h.

[0030] This application uses the above-mentioned fermentation culture conditions and maintains a fermentation cycle of 96-120 hours, which provides sufficient time window for the bumblebee yeast. By utilizing the hydrolytic enzymes such as β-glucosidase secreted by the yeast, the large molecular glycosides such as rutin in calendula can be gradually converted into small molecular aglycones such as quercetin, thereby enhancing the soothing and acne-removing effects of calendula.

[0031] As a preferred embodiment of the multi-effect acne-removing composition containing medicinal Fomitopsis pinnatifida extract described in this application, the pH value of the calendula basic extract in step S3 is adjusted to 3.5~4.0.

[0032] As a preferred embodiment of the multi-effect acne-removing composition containing medicinal Fomitopsis pilosula extract described in this application, the calendula basic extract in step S3 is further supplemented with 120~150 g / L glucose and 0.5~2.0 g / L ammonium sulfate.

[0033] This application adjusts the pH of the calendula basic extract to 3.5-4.0, which can effectively promote the synthesis and accumulation of sophorolipids and prevent contamination by other microorganisms; it ensures the specificity of the fermentation direction and the stability of the final product quality, so that the calendula fermentation extract can better inhibit Propionibacterium acnes.

[0034] The calendula basic extract of this application also contains 120~150 g / L of glucose. The glucose serves as a carbon source, creating a hypertonic and high-carbon environment that drives the efficient synthesis of sophorolipids by bumblebee Saccharomyces cerevisiae.

[0035] Preferably, in step S3, the centrifugation temperature is 4°C, the centrifugation speed is 10,000 rpm, and the centrifugation time is 20 min.

[0036] Preferably, in step S3, the particle size for filtration and sterilization is 0.22 μm.

[0037] This application also provides the use of the above-mentioned multi-effect acne-removing composition containing medicinal Fomitopsis pilosula extract in the preparation of cosmetics.

[0038] Preferably, the above-mentioned multi-effect acne-removing composition containing medicinal Fomitopsis pinnatifida extract is used in the preparation of cosmetics that inhibit emotional acne, repair, fade acne scars, and brighten skin tone.

[0039] The multi-effect acne-removing composition containing medicinal Fomitopsis pilosula extract provided in this application can be used to improve and prevent "emotional acne" caused or aggravated by emotional fluctuations such as stress, anxiety, and depression, and has the effect of fading acne marks and brightening skin tone. Therefore, it can be applied in the preparation of cosmetics to achieve the effects of cosmetics inhibiting emotional acne, repairing, fading acne marks, and brightening skin tone.

[0040] In some specific embodiments, the cosmetic includes at least one of toner, lotion, cream, mask, serum, and spray.

[0041] This application also provides a face cream comprising the following components in weight percentages: The multi-effect acne-removing composition containing medicinal Fomitopsis pilosula extract contains 0.5-5% thickener, 0.05-0.3% humectant, 0.5-1% emulsifier, 0.5-5% preservative, 0.5-3% pH adjuster, and the balance being water.

[0042] As a preferred embodiment of the face cream described in this application, at least one of the following is satisfied: a) The thickener comprises at least one of xanthan gum, carbomer, hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, ammonium acryloyldimethyl taurate / VP copolymer, sclerotium gum and cetyl alcohol; b) The moisturizer includes at least one of allantoin, betaine, beta-glucan, trehalose, caprylyl glycol, dipropylene glycol, sodium hyaluronate, 1,2-butanediol, glycerin and ceramide; c) The emulsifier includes at least one of C14-22 alcohol, C12-20 alkyl glucoside, cetearyl glucoside and sucrose stearate; d) The oil comprises at least one of caprylic / capric triglyceride, isononyl isononanoate, pentaerythritol tetraester, polydimethylsiloxane, and pentaerythritol distearate; e) The preservative includes at least one of 1,2-propanediol, 1,2-hexanediol, p-hydroxyacetophenone, and acrylate / C10-30 alkanol acrylate crosspolymers; f) The pH adjuster includes at least one of arginine, tromethamine, and disodium EDTA.

[0043] Compared with the prior art, this application has the following beneficial effects: This application provides a multi-effect acne-removing composition containing *Polyporus medica* extract and its application. This composition, through a compounding of *Polyporus medica* extract, calendula fermented extract, *Schisandra chinensis* extract, and red clover extract, is used to improve and prevent "emotional acne" caused or aggravated by emotional fluctuations such as stress, anxiety, and depression, and also has certain effects in fading acne scars and brightening skin tone. The multi-effect acne-removing composition containing *Polyporus medica* extract provided in this application achieves a multi-stage, multi-pathway synergistic effect from "preventing triggers" to "intervening in the process" and then to "repairing marks," thereby achieving the effects of multi-effect inhibition of emotional acne, repair, fading acne scars, and brightening skin tone. When this multi-effect acne-removing composition is applied to the preparation of cosmetics, it achieves the effects of cosmetics inhibiting emotional acne, repairing, fading acne scars, and brightening skin tone. Attached Figure Description

[0044] Figure 1 The improvement in facial appearance of subjects before and after using the product was observed in Application Example 1 and Control Application Example 7. Detailed Implementation

[0045] To better illustrate the purpose, technical solution, and advantages of this application, the following description will be provided in conjunction with the accompanying drawings and specific embodiments.

[0046] In the following examples and comparative examples, unless otherwise specified, the experimental methods used are conventional methods, and the materials and reagents used are commercially available unless otherwise specified. Furthermore, the raw materials used in each parallel experiment are the same.

[0047] In the following embodiments and comparative examples: The medicinal extract of *Fomitopsis pinnatifida* was purchased from BASF under the trade name Laricyl. ® LS 8865.

[0048] Schisandra chinensis extract is from Laboratoires Expanscience, marketed under the brand name SWEETONE. ® The red clover extract is produced in-house, and the extraction process follows the patent ZL2025103265125 Red Clover Extract 1.

[0049] The unfermented calendula extract is from Hezheng Biotechnology Co., Ltd., product number L2-SCB2436-X.

[0050] The green tea extract was purchased from Sunsource Biotechnology, under the trade name Green Tea Extract.

[0051] Forsythia extract: LQTQW01, Shaanxi Shize Tiancheng Biotechnology Co., Ltd.

[0052] Bidens trifoliata extract was purchased from CHEMYUNION under the brand name Revinage. ® .

[0053] The bumblebee yeast mentioned in the following calendula extract is from the China General Microbiological Culture Collection Center (CGC). Starmerella bombicola (CGMCC 2.3237).

[0054] The brewing yeast was obtained from the China General Microbiological Culture Collection Center ( Saccharomyces cerevisiae (CGMCC 2.10).

[0055] Calendula fermented extract 1 Homemade, the preparation method includes the following steps: S1. Dissolve the purchased Starmerella bombicola (CGMCC 2.3237) in an appropriate amount of sterile water and inoculate it onto a sterile malt extract agar (MEA) plate (Solepro, Cat: M8570). Activate the culture by incubating at 28°C for 48 hours. Pick a single colony and inoculate it onto a new 50 mL MEA medium plate. Incubate at 28°C and 180 rpm for 24 hours. Repeat the inoculation 2-3 times, culturing until the late logarithmic growth phase (OD50). 600 =12), pick the activated yeast cells and put them into sterile water to form a 10% bacterial solution for later use.

[0056] S2. Crush the dried organic calendula petals, mix the crushed calendula with deionized water at a ratio of 1:20 (g / mL), and hot extract at 80℃ for 1 hour. After filtration, obtain the basic calendula extract.

[0057] S3. Under aseptic conditions, the pH of the calendula basic extract was adjusted to 4.0. The bacterial culture was inoculated into the calendula basic extract at an inoculation rate of 15% of the weight of the calendula basic extract. 150 g / L of glucose was added to the calendula basic extract as a carbon source, while the nitrogen source ammonium sulfate was limited to 2 g / L.

[0058] S4. In the fermenter, control the stirring speed at 500 rpm, the aeration rate at 1.5 vvm, maintain the dissolved oxygen level at 30%, control the temperature at 28℃, and ferment for 120 hours.

[0059] S5. After fermentation, the fermentation broth was pasteurized at 85°C for 30 min; then centrifuged at 4°C and 10,000 rpm for 20 min, the supernatant was collected, and then filtered through a 0.22 μm filter membrane for sterilization. The resulting clear, slightly yellow liquid is the Calendula fermentation extract 1.

[0060] Calendula fermented extract 2 Homemade, the preparation method includes the following steps: S1. Dissolve the purchased Starmerella bombicola (CGMCC 2.3237) in an appropriate amount of sterile water and inoculate it onto a sterile malt extract agar (MEA) plate (Solepro, Cat: M8570). Activate the culture by incubating at 28°C for 48 hours. Pick a single colony and inoculate it onto a new 50 mL MEA medium plate. Incubate at 28°C and 180 rpm for 24 hours. Repeat the inoculation 2-3 times, culturing until the late logarithmic growth phase (OD50). 600 =10), pick the activated yeast cells and put them into sterile water to form a 10% bacterial solution for later use.

[0061] S2. Crush the dried organic calendula petals, mix the crushed calendula with deionized water at a ratio of 1:10 (g / mL), and hot extract at 60℃ for 1 hour. After filtration, obtain the basic calendula extract.

[0062] S3. Under aseptic conditions, the pH of the calendula basic extract was adjusted to 3.5. The bacterial culture was inoculated into the calendula basic extract at an inoculation rate of 5% of the weight of the calendula basic extract. 120 g / L of glucose was added to the calendula basic extract as a carbon source, while the nitrogen source ammonium sulfate was limited to 2 g / L.

[0063] S4. In the fermenter, control the stirring speed at 200 rpm, the aeration rate at 1.0 vvm, maintain the dissolved oxygen level at 20%, control the temperature at 25℃, and ferment for 96 hours.

[0064] S5. After fermentation, the fermentation broth was pasteurized at 85°C for 30 min; then centrifuged at 4°C and 10,000 rpm for 20 min, the supernatant was collected, and then filtered through a 0.22 μm filter membrane for sterilization. The resulting clear, slightly yellow liquid is the Calendula fermentation extract 2.

[0065] Calendula fermented extract 3 : Homemade, the preparation method includes the following steps: S1. Dissolve the purchased Starmerella bombicola (CGMCC 2.3237) in an appropriate amount of sterile water and inoculate it onto a sterile malt extract agar (MEA) plate (Solepro, Cat: M8570). Activate the culture by incubating at 28°C for 48 hours. Pick a single colony and inoculate it onto a new 50 mL MEA medium plate. Incubate at 28°C and 180 rpm for 24 hours. Repeat the inoculation 2-3 times, culturing until the late logarithmic growth phase (OD50). 600 = 11), pick the activated yeast and put it in sterile water to form a 10% bacterial solution for later use.

[0066] S2. Crush the dried organic calendula petals, mix the crushed calendula with deionized water at a ratio of 1:15 (g / mL), and hot extract at 80℃ for 1 hour. After filtration, obtain the basic calendula extract.

[0067] S3. Under aseptic conditions, the pH of the calendula basic extract was adjusted to 4.0. The bacterial solution was inoculated into the calendula basic extract at an inoculation rate of 8% of the weight of the calendula basic extract. 120 g / L of glucose was added to the calendula basic extract as a carbon source, while the nitrogen source ammonium sulfate was limited to below 2 g / L.

[0068] S4. In the fermenter, control the stirring speed at 300 rpm, the aeration rate at 1.5 vvm, maintain the dissolved oxygen level at 25%, control the temperature at 28℃, and ferment for 110 hours.

[0069] S5. After fermentation, the fermentation broth was pasteurized at 85°C for 30 min; then centrifuged at 4°C and 10,000 rpm for 20 min, the supernatant was collected, and then filtered through a 0.22 μm filter membrane for sterilization. The resulting clear, slightly yellow liquid is the Calendula fermentation extract 3.

[0070] Calendula fermented extract 4 Homemade, the only difference between this preparation method and Calendula fermented extract 1 is that in step S2, the pulverized calendula is mixed with deionized water at a ratio of 1:20 (g / mL), and the rest of the steps are the same as the preparation method of Calendula fermented extract 1.

[0071] Calendula fermented extract 5 Homemade, the only difference between this preparation method and Calendula fermented extract 1 is that in step S2, it is hot-extracted at 100℃ for 1 hour, and the rest of the steps are the same as the preparation method of Calendula fermented extract 1.

[0072] Calendula fermented extract 6 Homemade, the only difference between this and Calendula fermented extract 1 is that the pH of the calendula base extract is adjusted to 3.0 in step S3. The rest of the steps are the same as the preparation method of Calendula fermented extract 1.

[0073] Calendula fermented extract 7 Homemade, the only difference between this and Calendula fermented extract 1 is that the pH of the calendula base extract is adjusted to 5.0 in step S3. The rest of the steps are the same as the preparation method of Calendula fermented extract 1.

[0074] Calendula fermented extract 8 Homemade, the only difference between this and Calendula fermented extract 1 is that in step S1, common brewer's yeast is replaced with bumblebee saccharomyces cerevisiae. The rest of the steps are the same as the preparation method of Calendula fermented extract 1.

[0075] Examples 1-8 and Comparative Examples 1-8 The embodiments and comparative examples of this application provide a multi-effect acne treatment composition, the components (parts by weight) of which are shown in Table 1.

[0076] Table 1 The preparation method of the multi-effect acne-removing composition provided in Example 1 is as follows: the components are mixed and homogenized to obtain the multi-effect acne-removing composition.

[0077] The preparation methods of the multi-effect acne-removing compositions provided in Examples 2-8 and Comparative Examples 1-8 are the same as those in Example 1.

[0078] Example 9 This application provides a multi-effect acne treatment composition, the only difference between the multi-effect acne treatment composition and Example 3 is that calendula fermentation extract 2 is used instead of calendula fermentation extract 1.

[0079] Example 10 This application provides a multi-effect acne-removing composition, the only difference between the multi-effect acne-removing composition and Example 3 is that calendula fermented extract 3 is used instead of calendula fermented extract 1.

[0080] Example 11 This application provides a multi-effect acne treatment composition, the only difference between the multi-effect acne treatment composition and Example 3 is that calendula fermentation extract 4 is used instead of calendula fermentation extract 1.

[0081] Example 12 This application provides a multi-effect acne treatment composition, the only difference between the multi-effect acne treatment composition and Example 3 is that calendula fermentation extract 5 is used instead of calendula fermentation extract 1.

[0082] Example 13 This application provides a multi-effect acne treatment composition, the only difference between the multi-effect acne treatment composition and Example 3 is that calendula fermentation extract 6 is used instead of calendula fermentation extract 1.

[0083] Example 14 This application provides a multi-effect acne treatment composition, the only difference between the multi-effect acne treatment composition and Example 3 is that calendula fermentation extract 7 is used instead of calendula fermentation extract 1.

[0084] Comparative Example 9 This application provides a comparative example of a multi-effect acne treatment composition, the only difference between the multi-effect acne treatment composition and Example 3 is that green tea extract is used instead of medicinal fumonis extract.

[0085] Comparative Example 10 This application provides a comparative example of a multi-effect acne treatment composition, the only difference between the multi-effect acne treatment composition and Example 3 being the use of unfermented calendula extract instead of fermented calendula extract 1.

[0086] Comparative Example 11 This application provides a comparative example of a multi-effect acne-removing composition, the only difference between the multi-effect acne-removing composition and Example 3 is that the forsythia extract is used instead of the schisandra extract.

[0087] Comparative Example 12 This application provides a comparative example of a multi-effect acne treatment composition, the only difference between the multi-effect acne treatment composition and Example 3 is that Bidens trifoliata extract is used instead of red clover extract.

[0088] Comparative Example 13 This application provides a comparative example of a multi-effect acne treatment composition, the only difference between the multi-effect acne treatment composition and Example 3 is that the mass fraction of the medicinal Fomitopsis pilosula extract is 6 parts.

[0089] Comparative Example 14 This application provides a comparative example of a multi-effect acne-removing composition, the only difference between the multi-effect acne-removing composition and Example 3 is that the mass of Calendula fermented extract 1 is 4 parts.

[0090] Comparative Example 15 This application provides a comparative example of a multi-effect acne-removing composition, the only difference between the multi-effect acne-removing composition and Example 3 is that the mass fraction of Schisandra chinensis extract is 2 parts.

[0091] Comparative Example 16 This application provides a comparative example of a multi-effect acne treatment composition, the only difference between the multi-effect acne treatment composition and Example 3 is that the red clover extract is in parts by weight of 3.

[0092] Comparative Example 17 This application provides a comparative example of a multi-effect acne treatment composition, the only difference between the multi-effect acne treatment composition and Example 3 is that calendula fermentation extract 8 is used instead of calendula fermentation extract 1.

[0093] Application Examples 1-16 and Comparative Application Examples 1-17 This application provides a face cream in both application examples and comparative application examples. The components (mass percentage) of the face cream are shown in Table 2. In application examples 1 to 14, the multi-effect acne-removing compositions used are the multi-effect acne-removing compositions prepared in examples 1 to 14, respectively. In comparative application examples 1 to 17, the multi-effect acne-removing compositions used are the multi-effect acne-removing compositions prepared in comparative examples 1 to 14, respectively. In application examples 15 to 16, the multi-effect acne-removing compositions used are the multi-effect acne-removing compositions prepared in example 3.

[0094] Table 2 The method for preparing the face cream provided in Example 1 includes the following steps: (1) Mix the humectant and thickener with water and stir. Heat to 85±2℃ and homogenize at 1200 rpm for 4 min. After homogenization, keep warm for later use to obtain pre-prepared component A. (2) Mix the oil phase, heat to 85±2℃, and homogenize at 1200 rpm for 4 min. After homogenization, keep warm for later use to obtain the pre-prepared component B. (3) Mix the preservatives and heat to 60±2℃ to melt them, to obtain the pre-prepared component C; (4) Heat the pre-prepared component A to 80±2℃, add the pre-prepared component B at 250 rpm and stir to mix. Then cool down to 60±2℃ and add the pre-prepared component C at 250 rpm and stir to mix. Then cool down to 40℃ and add the multi-effect acne removal composition and continue stirring for 8 min. Finally, add the remaining pH adjuster to adjust the pH to 6.0, then stop stirring, discharge the product, and obtain the face cream.

[0095] The preparation methods of the face creams provided in Application Examples 2-16, Comparative Application Examples 1-17, and Blank Application Examples are consistent with those in Application Example 1.

[0096] Experimental Example 1: An experiment demonstrating how a multi-effect acne-reducing composition reduces neuronal overactivity and inflammation under stress. The stress factor cortisol induces increased neurosensory transmission in keratinocytes, marked by increases in calcitonin gene-related peptide (CGRP) and substance P, thus triggering mood-related acne. Therefore, after sample treatment, lower levels of CGRP and substance P indicate lower neuronal activity in cells under stress, and a stronger ability of the composition to combat mood-related acne.

[0097] Test substance preparation: Dilute the composition (Examples 1-14, Comparative Examples 1-17) to 0.05% using DMEM cell culture medium, and record it as the sample solution; refrigerate. The cell line used in this application is human keratinocytes (HaCaT) (provided by Guangzhou Customs Testing Center). The testing conditions were: incubator temperature 37±1℃, saturated humidity, and carbon dioxide 5±1%. Cells were cultured and treated according to groups, and then the contents of calcitonin gene-related peptide (CGRP) and substance P were determined. The testing methods are as follows: (1) Inoculate the cell suspension into culture flasks at a density of 1×10⁻⁶ cells / year. 6 Cells / mL, cultured in DMEM high glucose medium (Gibco) containing 10% fetal bovine serum for 24 hours; (2) The control group and the sample group were treated with 200 μL of PBS buffer containing 200 ng / mL cortisol for 30 minutes, and then the PBS buffer containing cortisol was discarded and the sample group was washed with PBS 3 times. (3) The control group was given DMEM high glucose culture medium containing 10% fetal bovine serum, and the sample groups were given DMEM high glucose culture medium containing 0.05% of the composition prepared in the example or comparative example (diluted with DEME) and 10% fetal bovine serum, respectively. After culturing for 24 hours, the cells were collected. (4) Determination of CGRP and substance P content: CGRP content was detected using the calcitonin gene-related peptide (CGRP) ELISA kit (Feien Biotech, catalog number EH1076) and substance P ELISA kit (Elabscience, catalog number E-EL-0067).

[0098] The ability of the composition to combat mood-related acne was expressed by the reduction in the levels of calcitonin gene-related peptide (CGRP) and substance P.

[0099] CGRP inhibition rate (%) = (1 - CGRP sample group / CGRP control group) × 100%; Inhibition rate of substance P (%) = (1 - substance P sample group / substance P control group) × 100%.

[0100] The results are shown in Table 3.

[0101] Table 3 As shown in Table 3, the multi-effect acne-removing composition of this application can reduce excessive inflammation caused by neurons under stress, and the composition has a strong ability to resist emotional acne. Specifically, the multi-effect acne-removing compositions prepared in Examples 1 to 14 showed CGRP inhibition rates of 54.9% to 83.2% and substance P inhibition rates of 63.3% to 92.3% in the tests.

[0102] As can be seen from Examples 1 to 8, the mass fraction of the components and the mass percentage of some components in the multi-effect acne-removing composition will affect the anti-emotional acne effect of the multi-effect acne-removing composition. When the mass fraction of the components is further selected within the range of this application, the prepared multi-effect acne-removing composition has a better ability to resist emotional acne.

[0103] As can be seen from Examples 3 and 9-14, different preparation methods for the calendula fermentation extract significantly affect the anti-emotional acne ability of the multi-effect acne-removing composition. In Comparative Example 17, which used common brewer's yeast instead of bumblebee *Saccharomyces cerevisiae* to prepare the calendula fermentation extract, the resulting multi-effect acne-removing composition showed lower CGRP inhibition rates and substance P inhibition rates, indicating poorer anti-emotional acne ability.

[0104] As can be seen from Examples 3 and Comparative Examples 1-8, when one or two of the components are not added, or when the mass fraction of one component is added to another component without adding the other component, the multi-effect acne-removing composition of this application cannot achieve the effect of anti-emotional acne. As can be seen from Examples 3 and Comparative Examples 13-16, when the amount of the component is excessive, the anti-emotional acne effect of the multi-effect acne-removing composition is not as good as that of Example 3. The above data show that the multi-effect acne-removing composition formed by the combination of specific components and their contents can better improve the anti-emotional acne ability. As can be seen from Examples 3 and Comparative Examples 9-12, when other components are used to replace the components in this application, the effect of the product also shows a certain downward trend, indicating that specific components can better improve the anti-emotional acne ability of the multi-effect composition. The medicinal styracidium extract, calendula fermented extract, schisandra chinensis extract and red clover extract within the mass fraction range of this application are compounded to improve and prevent "emotional acne" caused or aggravated by emotional fluctuations such as stress, anxiety, and depression.

[0105] Experimental Example 2: Inhibition Rate Test of Propionibacterium acnes Experimental Methods: Liquid thioglycolate medium (FT medium, Huankai Microbiology, REF: 028033) was prepared. Propionibacterium acnes was inoculated into the medium and cultured at 37℃ for 48 hours to form a bacterial suspension. The multi-effect acne-removing compositions of Examples 1-14 and Comparative Examples 1-17 were prepared as 1% (v / v) sample solutions using PBS. 180 μL of the bacterial suspension was added to a 96-well plate, followed by 40 μL of each sample solution to form sample groups. Control groups (bacterial suspension without sample solution) were also set up. After culturing for 24 hours, the OD value of each well was measured using a microplate reader. A lower OD value indicates clearer liquid, lower bacterial activity, and better antibacterial effect. The antibacterial rate was calculated using the following formula: Antibacterial rate (%) = (OD value of control group - OD value of sample group) / OD value of control group × 100%; Antibacterial rate data are shown in Table 4.

[0106] Table 4 As shown in Table 4, the multi-effect acne-removing composition of this application can effectively inhibit Propionibacterium acnes. Specifically, the multi-effect acne-removing compositions prepared in Examples 1-15 showed an inhibition rate of 71.9% to 100.0% against Propionibacterium acnes in the test.

[0107] As can be seen from Examples 1-8, the mass fraction of the components and the mass percentage of some components (medicinal Fertilizer Extract and Calendula Fermentation Extract) in the multi-effect acne-removing composition will affect the effect of the multi-effect acne-removing composition on inhibiting Propionibacterium acnes. When the mass fraction of the components is further selected within the range of this application, the prepared multi-effect acne-removing composition has better inhibition of Propionibacterium acnes.

[0108] As can be seen from Examples 3 and 9-14, the different preparation methods used for calendula extract significantly affect its inhibitory effect on Propionibacterium acnes in the multi-effect acne-removing composition. In Comparative Example 17, which used common Saccharomyces cerevisiae instead of Bumblebee Propionibacterium sarmentosum to prepare the calendula fermentation extract, the resulting multi-effect acne-removing composition showed a lower inhibition rate of Propionibacterium acnes.

[0109] As can be seen from Examples 3 and Comparative Examples 1-8, when one or two of the components are not added, or when a component is not added and its mass is added to another component, the multi-effect acne-removing composition of this application cannot achieve the effect of inhibiting Propionibacterium acnes. As can be seen from Examples 3 and Comparative Examples 13-16, when the amount of the components is excessive, the effect of the multi-effect acne-removing composition in inhibiting Propionibacterium acnes is not as good as in Example 3. The above data show that the multi-effect acne-removing composition formed by using specific components and their contents can better inhibit Propionibacterium acnes. Among them, compared with Comparative Examples 1-2, Comparative Examples 5-6 and Examples 1-14, it can be seen that the combination of medicinal Fomitopsis pilosula extract and Calendula officinalis extract achieves a stronger anti-Propionibacterium acnes effect. As can be seen from Examples 3 and Comparative Examples 9-12, when other components are used to replace the components in this application, the effect of the obtained multi-effect composition also shows a certain downward trend, indicating that the multi-effect composition formed by specific component combinations can better resist Propionibacterium acnes.

[0110] Experiment 3: Tests on suppressing emotional acne, fading acne scars, and brightening skin tone. One hundred and two volunteers with significant acne, blackheads, and papules were recruited and were under prolonged stress. The volunteers' stress levels were measured using the Perceived Stress Scale (CPSS-14) translated by Professor Yang Yanzhong. Those with a total score of 44 or higher (moderate to high stress) were selected for this test. Volunteers were randomly divided into 34 groups of three. Under normal circumstances, volunteers continuously used the product on their entire face for 14 days. Each morning and evening, after cleansing and moisturizing, volunteers applied an appropriate amount of face cream (Application Examples 1-16, Control Examples 1-17, and Blank Example) to their face, massaging until absorbed. The product was used on the entire face twice a day, morning and evening. Follow-up visits were conducted after 14 days.

[0111] On the day of their visit, volunteers washed their faces with water without applying any products and sat quietly for 20 minutes in an air-conditioned room with a temperature of 21±1℃ and humidity of 50±10%. The improvement in facial skin was assessed using instruments, including acne counting (calculating the total number of blackheads and papules using VISIA and doctor evaluation) and Tewameter. TM The Hex assay was used to measure transepidermal water loss (TEWL), the Colorimeter CL 400 was used to measure the color of acne scars (ITA° value) and the brightness (L* value) of the cheekbone, and the VISIA assay was used to measure the area of ​​the red area. Additionally, at the initial stage and 14 days later, 3 mL of saliva was collected from volunteers and the cortisol level was measured using a cortisol detection kit (Beyotime, catalog number PC169) according to the instructions.

[0112] Improvement rate of TEWL, number of acne, color of acne scars, and cortisol before and after use = (mean before use - mean after use) / mean before use × 100%; Improvement rate of skin tone brightness before and after use = (mean after use - mean before use) / mean before use × 100%.

[0113] The calculation results are shown in Table 5. The improvement rate presented in Table 5 is the improvement rate at the follow-up visit on day 14.

[0114] Table 5 From the results in Table 5 and Figure 1 It is known that when the multi-effect acne-removing composition of this application is applied to a face cream, the resulting face cream can effectively inhibit emotional acne, lighten acne scars, and brighten skin tone. Specifically, the face creams prepared using Examples 1 to 16 showed a TEWL improvement rate of 12.3% to 29.3%, an acne number improvement rate of 66.4% to 40.3%, a skin tone brightness improvement rate of 6.3% to 45.2%, an acne scar color improvement rate of 32.1% to 64.3%, and a cortisol improvement rate of 8.1% to 25.7% in the tests.

[0115] As can be seen from Application Examples 1 to 8, the mass fraction of the components in the multi-effect acne-removing composition and the mass percentage of some components in the face cream will affect the face cream's effect on inhibiting emotional acne, fading acne marks, and brightening skin tone. When the mass fraction of the components is further selected within the range of this application, the prepared multi-effect acne-removing composition is better at inhibiting emotional acne, fading acne marks, and brightening skin tone.

[0116] As can be seen from Application Examples 3 and 9-16, the effects of different preparation methods on the efficacy of calendula extract in inhibiting mood-related acne, fading acne scars, and brightening skin tone in face creams are significantly affected. In contrast, Application Example 17, which used common brewer's yeast instead of bumblebee *Saccharomyces cerevisiae* to prepare calendula fermented extract, showed lower TEWL (transient acne lesions) improvement rates, acne count improvement rates, skin tone brightness improvement rates, acne scar color improvement rates, and cortisol improvement rates in the prepared multi-effect acne-reducing composition. This indicates that using calendula fermented extract obtained from bumblebee *Saccharomyces cerevisiae* fermentation in face creams can enhance the effects of inhibiting mood-related acne, fading acne scars, and brightening skin tone.

[0117] As can be seen from Application Example 3 and Comparative Application Examples 1-8, when one or two of the components are not added, or when a component is not added and its mass fraction is added to another component, the multi-effect acne-removing composition of this application cannot achieve the effects of inhibiting emotional acne, fading acne scars, and brightening skin tone. As can be seen from Application Example 3 and Comparative Application Examples 13-16, when the component fraction is excessive, the multi-effect acne-removing composition is less effective than Application Example 3 in inhibiting emotional acne, fading acne scars, and brightening skin tone. The above data indicate that a multi-effect acne-removing composition formed by combining specific components and their concentrations can better inhibit emotional acne, fade acne scars, and brighten skin tone. Among these, the comparative applications... Compared with Examples 1-2, Comparative Application Examples 5-6, and Comparative Application Examples 8 and 1-14, it can be seen that the combination of *Polyporus medicata* extract and calendula extract achieves a strong anti-proteus acnes effect. The combination of *Polyporus medicata* extract, calendula extract, and Schisandra chinensis extract has a synergistic anti-inflammatory effect. Comparative Application Examples 3-4 and 7-8 show the synergistic effect of red clover extract and Schisandra chinensis extract in reducing emotional stress. From Application Example 3 and Comparative Application Examples 9-12, it can be seen that when other components are used to replace the components in this application, the effects of the obtained face cream in inhibiting emotional acne, fading acne marks, and brightening skin tone also show a certain downward trend.

[0118] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of this application and are not intended to limit the scope of protection of this application. Although this application has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can be made to the technical solutions of this application without departing from the substance and scope of the technical solutions of this application.

Claims

1. A multi-effect acne-removing composition containing medicinal Fomitopsis pinnatifida extract, characterized in that, The multi-effect acne treatment composition comprises the following components in parts by weight: 0.05-5 parts of medicinal Fomitopsis pilosula extract, 0.05-3 parts of Calendula officinalis fermented extract, 0.01-1 parts of Schisandra chinensis extract and 0.05-2 parts of red clover extract; The calendula fermented extract is a calendula extract using bumblebee stamina yeast. Starmerella bombicola The product obtained from fermentation.

2. The multi-effect acne-removing composition containing medicinal Fomitopsis pinnatifida extract as described in claim 1, characterized in that, The multi-effect acne treatment composition comprises the following components in parts by weight: 1.5-3 parts of medicinal Fomitopsis pilosula extract, 0.1-0.5 parts of Calendula officinalis fermented extract, 0.05-0.2 parts of Schisandra chinensis extract and 0.5-1 parts of red clover extract.

3. The multi-effect acne-removing composition containing medicinal Fomitopsis pinnatifida extract as described in claim 1, characterized in that, Based on the total mass of the multi-effect acne-removing composition, the sum of the masses of the medicinal Ferula melitica extract and Calendula fermentation product accounts for 65% to 75%.

4. The multi-effect acne-removing composition containing medicinal Fomitopsis pinnatifida extract as described in claim 1, characterized in that, The preparation method of the calendula fermentation extract includes the following steps: S1. Activate the bumblebee yeast to obtain the activated bacterial solution; S2. Crush the dried calendula flowers, mix the crushed calendula flowers with deionized water, and perform hot extraction to obtain the basic calendula flower extract. S3. Inoculate the bacterial culture from step S1 into the calendula basic extract obtained in step S2 for fermentation culture to obtain fermentation broth. Centrifuge the fermentation broth, take the supernatant, filter and sterilize to obtain calendula fermentation extract.

5. The multi-effect acne-removing composition containing medicinal Fomitopsis pinnatifida extract as described in claim 4, characterized in that, In step S2, the mass-to-volume ratio of the pulverized calendula flowers to deionized water is 1g:(10~20)mL; And / or, In step S2, the hot extraction temperature is 60~80℃ and the hot extraction time is 1~3h.

6. The multi-effect acne-removing composition containing medicinal Fomitopsis pinnatifida extract as described in claim 4, characterized in that, In step S3, the inoculation amount of the bacterial solution is 5-15%; And / or, the conditions for fermentation culture include: The rotation speed is 200~500 rpm, the aeration rate is 1.0~1.5 vvm, the dissolved oxygen level is 20~30%, the temperature is 25~28℃, and the fermentation time is 96~120h.

7. The multi-effect acne-removing composition containing medicinal Fomitopsis pinnatifida extract as described in claim 4, characterized in that, In step S3, the pH value of the calendula basic extract is adjusted to 3.5~4.0; And / or, In step S3, the calendula basic extract also contains 120-150 g / L of glucose and 0.5-2.0 g / L of ammonium sulfate.

8. The use of the multi-effect acne-removing composition containing medicinal fusiforme extract as described in any one of claims 1 to 7 in the preparation of cosmetics.

9. A face cream, characterized in that, The face cream comprises the following components by weight percentage: The multi-effect acne-removing composition containing medicinal Fomitopsis pilosula extract as described in any one of claims 1 to 7 comprises 0.5 to 5% thickener, 0.05 to 0.3% humectant, 0.5 to 1% emulsifier, 0.5 to 5% preservative, 0.5 to 3% pH adjuster, and the balance being water.

10. The face cream as described in claim 9, characterized in that, Satisfy at least one of the following: a) The thickener comprises at least one of xanthan gum, carbomer, hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, ammonium acryloyldimethyl taurate / VP copolymer, sclerotium gum and cetyl alcohol; b) The moisturizer includes at least one of allantoin, betaine, beta-glucan, trehalose, caprylyl glycol, dipropylene glycol, sodium hyaluronate, 1,2-butanediol, glycerin and ceramide; c) The emulsifier includes at least one of C14-22 alcohol, C12-20 alkyl glucoside, cetearyl glucoside and sucrose stearate; d) The oil comprises at least one of caprylic / capric triglyceride, isononyl isononanoate, pentaerythritol tetraester, polydimethylsiloxane, and pentaerythritol distearate; e) The preservative includes at least one of 1,2-propanediol, 1,2-hexanediol, p-hydroxyacetophenone, and acrylate / C10-30 alkanol acrylate crosspolymers; f) The pH adjuster includes at least one of arginine, tromethamine, and disodium EDTA.

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