Method for electrochemical synthesis of chalcone compounds
By utilizing the free radical relay mechanism of electrochemistry and TBHP synergistic catalysis, the problems of low yield and difficult wastewater treatment in traditional chalcone synthesis have been solved, achieving efficient, green, and compatible chalcone synthesis applicable to a variety of functional groups.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- WANHUA CHEM GRP CO LTD
- Filing Date
- 2025-12-12
- Publication Date
- 2026-04-14
AI Technical Summary
Existing methods for synthesizing chalcones require strong base or strong acid catalysis, resulting in low yields. They are also incompatible with acid/base sensitive functional groups and generate large amounts of difficult-to-treat wastewater.
An electrochemical synthesis method was adopted, in which compounds A and B reacted with tert-butyl hydrogen peroxide in an electrolyte solution by electrolysis. The free radical relay mechanism of electrochemistry and TBHP synergistic catalysis was utilized to achieve the efficient synthesis of chalcone. The reaction conditions were mild and applicable to a variety of functional groups.
This method achieves efficient and highly selective synthesis of chalcones with high yield and purity, compatibility with multiple functional groups, is environmentally friendly, easy to operate, and has good prospects for industrial application.
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Abstract
Description
Technical Field
[0001] This invention relates to the field of preparing chalcone compounds, and more specifically to a method for the electrochemical synthesis of chalcone compounds. Background Technology
[0002] Chalcones (Ar-CO-CH=CH-Ar') are core structural units in many natural products and bioactive molecules, with wide applications in medicine, pesticides, and materials science. Their traditional synthesis primarily relies on Claisen-Schmidt condensation reactions catalyzed by bases or acids. However, these reactions require strong base or strong acid catalysis and heating, and generally suffer from low yields. In particular, they exhibit poor compatibility with acid / base-sensitive functional groups (such as aldehydes, cyanos, nitros, and halogens), resulting in even lower yields or even failures in the synthesis of chalcones with these functional groups.
[0003] Therefore, developing a novel electrochemical synthesis method for chalcone with mild conditions, high efficiency, and good functional group compatibility has significant research value and application potential. Summary of the Invention
[0004] To address the shortcomings of existing technologies, the present invention aims to develop a novel electrochemical synthesis method for chalcone that is mild, green, efficient, and has good functional group compatibility.
[0005] Therefore, this application provides a method for the electrochemical synthesis of chalcone compounds, wherein compound A (general formula Ar-CH=CH2), compound B (general formula Ar'-CHO), and tert-butyl hydrogen peroxide are mixed with an electrolyte solution and reacted with an electron to obtain chalcone compounds; wherein the electrolyte solution comprises an electrolyte and a solvent, the solvent comprising C1-C4 carboxylic acids and water; Ar and Ar' are independently selected from unsubstituted or Rm-substituted aryl groups; Rm is selected from H, hydroxyl, -CN, -NO2, halogen, C1-C4 alkyl, halogen-substituted C1-C4 alkyl, C1-C4 alkoxy, C3-C6 cycloalkyl, C6-C8 aryl or heterocyclic aryl.
[0006] In this application, "halogen" is F, Cl, Br or I.
[0007] In some embodiments, the general structural formula of compound A is as follows: ; Wherein, R1 is selected from H, hydroxyl, -CN, -NO2, halogen, C1-C4 alkyl, halogen-substituted C1-C4 alkyl, C1-C4 alkoxy, C3-C6 cycloalkyl, C6-C8 aryl or heterocyclic aryl; preferably, R1 is selected from H, -CN, -NO2, halogen, halogen-substituted C1-C4 alkyl, C1-C4 alkyl or C1-C4 alkoxy; preferably, R1 is selected from H, F, Cl, Br, -NO2, -CF3, -CN, -OCH3 or C1-C2 alkyl; more preferably, R1 is selected from H or C1-C2 alkyl.
[0008] In some embodiments, the general structural formula of compound B is as follows: ; Wherein, R2 is selected from H, hydroxyl, -CN, CF3, -NO2, halogen, C1-C4 alkyl, halogen-substituted C1-C4 alkyl, C1-C4 alkoxy, C3-C6 cycloalkyl, C6-C8 aryl or heterocyclic aryl; preferably, R2 is selected from H, halogen, -NO2, C1-C4 alkyl or C1-C4 alkoxy; preferably, R2 is selected from H, F, -NO2, methoxy, ethoxy or C1-C2 alkyl; more preferably, R1 is selected from H or C1-C2 alkyl.
[0009] In some embodiments, compound A is selected from one or more compounds having the following structural formulas: ; and / or, Compound B is selected from one or more compounds having the following structural formulas: .
[0010] In some embodiments, the molar ratio of compound A, compound B and tert-butyl hydroperoxide is 2.5–3.5:1.5–2.5:1, preferably 3:2:1.
[0011] In some embodiments, the electrolyte is selected from one or more of tetrabutylammonium hexafluorophosphate, lithium perchlorate, or tetrabutylammonium tetrafluoroborate; and / or, the C1-C4 carboxylic acid is selected from one or more of formic acid, acetic acid, propionic acid, and butyric acid.
[0012] In some embodiments, the mass ratio of compound A to the electrolyte solution is 3:140-160; and / or, the mass ratio of C1-C4 carboxylic acids to water in the electrolyte solution is 1:5 to 4:1; and / or, the molar concentration of the electrolyte in the solvent is 0.05-0.3M.
[0013] In some embodiments, the electrolytic reaction is carried out in a single-chamber electrolytic cell under an inert or nitrogen atmosphere.
[0014] In some embodiments, the anode of the energized reaction is a platinum electrode, a graphite electrode, or a glassy carbon electrode; and / or, the cathode of the energized reaction is a platinum electrode, a copper electrode, a silver electrode, or a nickel electrode.
[0015] In some embodiments, the electrochemical reaction is carried out at room temperature for a time of 1 to 4 hours.
[0016] In some embodiments, the electrolytic reaction is carried out under constant potential conditions, and the electrolysis voltage is 1.0V to 1.5V, preferably 1.1V to 1.3V.
[0017] Under strongly basic Claisen-Schmidt reaction conditions, the following functional groups are generally unstable and incompatible, resulting in lower yields or even failures in the synthesis of chalcones containing these functional groups.
[0018] (1) Aldehyde group (-CHO): It undergoes the Cannizaro reaction.
[0019] (2) Ester group (-COOR), cyano group (-CN), nitro group (-NO2): may hydrolyze or undergo other side reactions under strong base conditions.
[0020] (3) Acidic groups: such as phenolic hydroxyl (-OH) and carboxyl (-COOH) will form salts under strong base conditions, which will change the properties of the reactants.
[0021] (4) Halogens (-Cl, -Br): may be unstable, especially under high temperature and strong alkali conditions.
[0022] The reaction system of this invention is applicable to the synthesis of chalcone compounds containing these functional groups.
[0023] Furthermore, the Claisen-Schmidt reaction requires acid neutralization of the large amount of strong alkali in the reaction solution, resulting in high-salinity organic-inorganic mixed wastewater, which is difficult and costly to treat. In contrast, the reaction system of this invention is neutral, requiring no subsequent neutralization step. Moreover, the solvent of this invention is recyclable, and the electrolyte system (acetic acid / water / electrolyte) theoretically has the potential for recycling after simple treatment (such as distillation), thereby reducing wastewater discharge at the source. Furthermore, the wastewater from this invention has low toxicity; the post-treatment wastewater mainly contains trace amounts of acetic acid and tert-butanol, and does not contain high concentrations of inorganic salts or toxic heavy metals, making its biochemical treatment far less difficult than that of neutralizing wastewater using traditional methods.
[0024] The technical solution of this invention has the following advantages: 1. The present invention provides a method for the electrochemical synthesis of chalcone compounds, which involves mixing compound A (general formula Ar-CH=CH2), compound B (general formula Ar'-CHO), tert-butyl hydroperoxide (TBHP), and an electrolyte solution, followed by an electrochemical reaction to obtain chalcone compounds. This invention achieves efficient and highly selective synthesis of chalcones through a novel free radical relay mechanism synergistically catalyzed by electrochemistry and TBHP. The method is characterized by mild conditions, simple operation, excellent yield and purity, good substrate functional group compatibility, and the absence of expensive catalysts, demonstrating promising prospects for industrial application.
[0025] Specifically: ① The reaction is novel and has a unique mechanism: it pioneers a free radical relay mechanism of "electrochemical / TBHP" synergistic catalysis (cathodic reduction of TBHP initiation → free radical addition → anodic oxidation dehydrogenation), providing a new and efficient pathway for chalcone synthesis. ② Extremely mild conditions: room temperature reaction, narrow potential window, and low energy consumption. ③ High yield and purity: significantly superior to traditional methods. ④ Excellent functional group compatibility: it has good tolerance to both electron-donating groups (-OCH3, -CH3) and electron-withdrawing groups (-Cl, -Br, -F, -NO2, -CF3, -CN, etc.), with broad substrate universality. ⑤ Green and environmentally friendly: the current is a green reagent, and the byproducts are only tert-butanol and water, resulting in high atom economy. ⑥ Low cost and simple operation: no expensive metal catalysts are required, and post-processing is simple, requiring only extraction, concentration, and purification. ⑦ Easy to scale up: gram-scale experiments have been successfully completed, with no significant decrease in yield and purity, demonstrating good prospects for industrial application. Furthermore, there are no metal residues.
[0026] 2. The electrochemical synthesis method for chalcone compounds provided by this invention, by selecting tetrabutylammonium hexafluorophosphate as the electrolyte, results in a more thorough reaction and a significantly improved yield.
[0027] 3. The method for electrochemical synthesis of chalcone compounds provided by the present invention can further improve the selectivity of the reaction and reduce the occurrence of side reactions by controlling the electrolysis voltage at 1.0V to 1.5V, especially 1.1-1.3V, thereby effectively improving the yield and purity of the product. Detailed Implementation
[0028] The following embodiments are provided to better understand the present invention, but the following embodiments do not constitute a limitation on the content and scope of protection of the present invention. Any product that is the same as or similar to the present invention, derived by any person under the guidance of the present invention or by combining the features of the present invention with other prior art, falls within the scope of protection of the present invention.
[0029] Unless otherwise specified, all experimental steps or conditions in the examples were performed according to conventional experimental procedures and conditions in the art. Reagents or instruments whose manufacturers are not specified are all commercially available products.
[0030] The HPLC analysis method is as follows: The analyte was dissolved in methanol to prepare a methanol solution with a concentration of approximately 0.5 mg / mL, which was then injected for detection. The chromatographic conditions were as follows: the column was a ZORBAX SB-C18 (4.6 × 250 mm, 5 μm); the column temperature was 30°C; mobile phase A was 0.1% trifluoroacetic acid aqueous solution, and mobile phase B was acetonitrile, with gradient elution (0 min, 50% B; 20 min, 95% B; 25 min, 95% B); the flow rate was 1.0 mL / min; and the detection wavelength was 220 nm.
[0031] Example 1 Synthesis of (E)-1,3-diphenyl-2-propen-1-one This embodiment provides a method for the electrochemical synthesis of chalcone compounds, and the reaction equation and preparation method are as follows:
[0032] (1) Preparation of crude product: In a 50 mL membrane-free single-chamber electrolytic cell, a magnetic stir bar, styrene (3.0 mmol, 312 mg), benzaldehyde (2.0 mmol, 212 mg), tert-butyl hydroperoxide (TBHP, 1.0 mmol, added as a 70% aqueous solution), tetrabutylammonium hexafluorophosphate (TBAPF6, 0.1 M, with a molar concentration of 0.1 M in the mixed solvent of acetic acid and water), and 15 g of a mixed solvent of acetic acid and water (mass ratio 1:1) were added. Platinum anode and platinum cathode were installed, and the system was evacuated and purged with nitrogen three times to remove oxygen. Subsequently, the electrolysis reaction was carried out at room temperature and 1.2 V with stirring for 2 hours. The reaction progress was monitored by TLC.
[0033] (2) Post-processing: After the reaction was completed, the reaction solution was extracted with ethyl acetate (3 × 20 mL). The organic phases were combined, washed successively with water and saturated brine, dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel column chromatography (petroleum ether / ethyl acetate (V / V) = 20:1) to give 396 mg of the white flaky crystalline product (E)-1,3-diphenyl-2-propen-1-one, with a yield of 95%. The product was further processed... 1 H NMR, 13 C NMR and HRMS confirmed consistency with the standard, and HPLC analysis showed a purity of 99.2%.
[0034] 1 H NMR(600 MHz, CDCl3): δ (ppm) = 8.04– 8.01(m, 2H), 7.82 (d, J = 15.7,1H), 7.68–7.63 (m, 2H), 7.59 (t, J = 7.6, 1H), 7.56–7.50 (m,3H), 7.45–7.40 (m,3H); 13 C NMR (150 MHz, CDCl3): δ (ppm) =190.6, 144.9, 138.2, 134.9, 132.8,130.6, 129.0, 128.7, 128.5, 128.5,122.1. Example 2 This embodiment provides a method for the electrochemical synthesis of chalcone compounds, which is basically the same as that in Example 1, except that p-chlorobenzaldehyde (2.0 mmol) is used instead of benzaldehyde in this embodiment, and the other conditions are the same as in Example 1. After reacting for 2.5 hours, the product is processed in the same way to obtain pure p-chlorochalcone with a yield of 94% and a purity of 98.6% as shown by HPLC analysis.
[0035] 1 H NMR (300 MHz, CDCl3) δ7.98-7.95(d, J = 9 Hz, 2H), 7.84-7.79(d, J = 15Hz, 1H), 7.66-7.62(m,2H), 7.51-7.46(t, J = 9 Hz, 2H), 7.51-7.46 (d, J = 15 Hz,1H), 7.43-7.41(m, 3H). 13 C NMR (75 MHz, CDCl3) δ 189.4, 145.6, 139.4,136.7, 134.9, 131.0,130.1, 129.2, 128.7, 121.7. Example 3 This embodiment provides a method for the electrochemical synthesis of chalcone compounds, which is basically the same as that in Example 1, except that p-methoxystyrene (3.0 mmol) is used instead of styrene in this embodiment, and the other conditions are the same as in Example 1. After reacting for 1.5 hours, p-methoxychalcone was obtained by the same post-processing method, with a yield of 95% and a purity of 96.4% as shown by HPLC analysis.
[0036] 1 H NMR (400 MHz, CDCl3) δ 8.02 – 7.90 (m, 2H), 7.71 (d, J = 15.6 Hz,1H), 7.58 – 7.50 (m, 2H), 7.45 (d, J = Hz, 1H), 7.38 – 7.24 (m, 3H), 6.94 – 6.79 (m, 2H), 3.78 (s, 3H). 13 C NMR (101 MHz, CDCl3) δ 187.6, 162.4, 142.9, 134.0, 130.0, 129.8,129.3, 127.9, 127.3, 120.8,112.8, 54.4. Example 4 Gram-scale experiment This embodiment provides a method for the electrochemical synthesis of chalcone compounds, comprising the following steps: (1) Preparation of crude product: In a 250 mL single-chamber electrolytic cell, a magnetic stir bar, styrene (30.0 mmol, 3120 mg), benzaldehyde (20.0 mmol, 2120 mg), tert-butyl hydroperoxide (TBHP, 10.0 mmol, added as a 70% aqueous solution), tetrabutylammonium hexafluorophosphate (TBAPF6, 0.1 M), and a mixed solvent of 150 g of acetic acid and water (mass ratio 1:1) were added. Platinum anode and platinum cathode were installed, and the system was evacuated and purged with nitrogen three times to remove oxygen. Subsequently, an electrolytic reaction was carried out at room temperature with a voltage of 1.2 V and stirred for 2.5 hours. The reaction progress was monitored by TLC.
[0037] (2) Post-processing: After the reaction was completed, the reaction solution was extracted with ethyl acetate (3 × 20 mL). The organic phases were combined, washed successively with water and saturated brine, dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel column chromatography (petroleum ether / ethyl acetate (V / V) = 20:1) to give 3.94 g of white flaky crystals (E)-1,3-diphenyl-2-propen-1-one, with a yield of 95%. The product was further processed... 1H NMR, 13 C NMR and HRMS confirmed consistency with the standard, and HPLC analysis showed a purity of 99.5%. This experiment demonstrates the scalability of the method.
[0038] Example 5 This embodiment is basically the same as Example 1, except that the same number of moles of lithium perchlorate (LiClO4) is used instead of tetrabutylammonium hexafluorophosphate. The yield of (E)-1,3-diphenyl-2-propen-1-one is 89%, and the purity is 97.9%.
[0039] Example 6 This example is basically the same as Example 1, except that the same number of moles of tetrabutylammonium tetrafluoroborate (TBABF4) is used instead of tetrabutylammonium hexafluorophosphate. The yield of (E)-1,3-diphenyl-2-propen-1-one is 91%, and the purity is 98.6%.
[0040] Examples 7-14 This embodiment provides a series of methods for the electrochemical synthesis of chalcone compounds. The preparation methods are the same as in Example 1, except that compounds A and B are different. The structural formulas of compounds A and B used in Examples 7-14 and the reaction results are shown in Table 1.
[0041] Table 1. Structural formulas of compounds A and B and reaction results.
[0042] Example 15 The reaction was basically the same as in Example 1, except that the voltage in step (1) was adjusted to 1.0V and the stirring time was extended to 10 hours. The results showed that the yield of product (E)-1,3-diphenyl-2-propen-1-one decreased to 68%, and the purity was 98.0%.
[0043] When the voltage drops to 1.0V, the defect manifests as sluggish reaction kinetics. Insufficient reaction initiation leads to a slow reaction rate and incomplete conversion. Even with extended reaction time, the yield is significantly lower than under optimal conditions, and byproducts are generated.
[0044] Example 16 The procedure was essentially the same as in Example 1, except that the voltage in step (1) was adjusted to 1.5V. The results showed that the yield of the product (E)-1,3-diphenyl-2-propen-1-one decreased to 75%, with a purity of 98.2%.
[0045] When the voltage is too high, such as 1.5V, although the conversion of the raw materials may be very fast, the selectivity of the target product is significantly reduced, resulting in a lower product yield, an increase in the occurrence of side reactions, and a slightly lower product purity.
[0046] Compared with Example 1, Examples 15-16 show that Example 1, by controlling the voltage within a preferred range, can further improve the selectivity of the reaction while maintaining a high conversion rate, reduce the occurrence of side reactions, and thus obtain chalcone compounds with higher yield and purity.
[0047] Example 17 This embodiment provides a method for the electrochemical synthesis of chalcone compounds, and the reaction equation and preparation method are as follows:
[0048] (1) Preparation of crude product: In a 50 mL single-chamber electrolytic cell, a magnetic stir bar, styrene (2 mmol, 312 mg), benzaldehyde (2.0 mmol, 212 mg), tert-butyl hydroperoxide (TBHP, 1.0 mmol, added as a 70% aqueous solution), tetrabutylammonium hexafluorophosphate (TBAPF6, 0.2 M, with a molar concentration of 0.2 M in the mixed solvent of acetic acid and water), and 15 g of a mixed solvent of formic acid and water (mass ratio 1:5) were added. Platinum anode and platinum cathode were installed, and the system was evacuated and purged with nitrogen three times to remove oxygen. Subsequently, a voltage of 1.3 V was applied at room temperature, and the reaction was stirred for 3 hours. The reaction progress was monitored by TLC.
[0049] (2) Post-processing: After the reaction was completed, the reaction solution was extracted with ethyl acetate (3 × 20 mL). The organic phases were combined, washed successively with water and saturated brine, dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel column chromatography (petroleum ether / ethyl acetate (V / V) = 20:1) to give 371 mg of the white flaky crystalline product (E)-1,3-diphenyl-2-propen-1-one, with a yield of 89%. The product was subjected to... 1 H NMR, 13 C NMR and HRMS confirmed consistency with the standard, and HPLC analysis showed a purity of 99.1%.
[0050] Example 18 The procedure was essentially the same as in Example 1, except that the molar amounts of styrene and benzaldehyde were adjusted to 2.5 mmol. The yield of (E)-1,3-diphenyl-2-propen-1-one was 80%, and the purity was 99.3%.
[0051] Example 19 The procedure was essentially the same as in Example 1, except that the molar amount of styrene was adjusted to 3.5 mmol and the molar amount of benzaldehyde was adjusted to 1.5 mmol. The yield of (E)-1,3-diphenyl-2-propen-1-one was 77%, and the purity was 98.6%.
[0052] Comparative Example 1 This comparative example was identical to Example 1 except that no voltage was applied. After stirring for 4 hours, TLC and HPLC monitoring showed that the starting material did not react, confirming the indispensability of the electrochemical process in this method.
[0053] Comparative Example 2 This comparative example is basically the same as Example 1, except that the same mass of ethanol is used instead of acetic acid, and the yield of (E)-1,3-diphenyl-2-propen-1-one is only 32%.
[0054] Comparative Example 3 The reaction was essentially the same as in Example 1, except that hydrogen peroxide (H2O2, 1.0 mmol, added as a 35% aqueous solution by mass) was used instead of tert-butyl hydrogen peroxide, and the reaction was stirred for 2 hours. TLC and HPLC monitoring showed that the starting material did not react. The reaction time was extended to 6 hours, and TLC and HPLC monitoring still showed that the starting material did not react.
[0055] Obviously, the above embodiments are merely illustrative examples for clear explanation and are not intended to limit the implementation. Those skilled in the art will recognize that other variations or modifications can be made based on the above description. It is neither necessary nor possible to exhaustively list all possible implementations here. However, obvious variations or modifications derived therefrom are still within the scope of protection of this invention.
Claims
1. A method for the electrochemical synthesis of chalcone compounds, characterized in that, Compound A (represented by the general formula Ar-CH=CH2), compound B (represented by the general formula Ar'-CHO), and tert-butyl hydrogen peroxide are mixed with an electrolyte solution and reacted with an electron pump to obtain chalcone compounds. The electrolyte solution comprises an electrolyte and a solvent, wherein the solvent comprises C1-C4 carboxylic acids and water. Ar and Ar' are independently selected from unsubstituted or Rm-substituted aryl groups. Rm is selected from H, hydroxyl, -CN, -NO2, halogen, C1-C4 alkyl, halogen-substituted C1-C4 alkyl, C1-C4 alkoxy, C3-C6 cycloalkyl, C6-C8 aryl, or heterocyclic aryl.
2. The method for electrochemical synthesis of chalcone compounds according to claim 1, characterized in that, The general structural formula of compound A is as follows: ； Wherein, R1 is selected from H, hydroxyl, -CN, -NO2, halogen, C1-C4 alkyl, halogen-substituted C1-C4 alkyl, C1-C4 alkoxy, C3-C6 cycloalkyl, C6-C8 aryl or heterocyclic aryl; preferably, R1 is selected from H, -CN, -NO2, halogen, halogen-substituted C1-C4 alkyl, C1-C4 alkyl or C1-C4 alkoxy; more preferably, R1 is selected from H, F, Cl, Br, -NO2, -CF3, -CN, -OCH3 or C1-C2 alkyl; even more preferably, R1 is selected from H or C1-C2 alkyl.
3. The method for electrochemical synthesis of chalcone compounds according to claim 1 or 2, characterized in that, The general structural formula of compound B is as follows: ； Wherein, R2 is selected from H, hydroxyl, -CN, CF3, -NO2, halogen, C1-C4 alkyl, halogen-substituted C1-C4 alkyl, C1-C4 alkoxy, C3-C6 cycloalkyl, C6-C8 aryl or heterocyclic aryl; preferably, R2 is selected from H, halogen, -NO2, C1-C4 alkyl or C1-C4 alkoxy; preferably, R2 is selected from H, F, -NO2, methoxy, ethoxy or C1-C2 alkyl; more preferably, R1 is selected from H or C1-C2 alkyl.
4. The method for electrochemical synthesis of chalcone compounds according to any one of claims 1-3, characterized in that, Compound A is selected from one or more compounds having the following structural formulas: ; and / or, Compound B is selected from one or more compounds having the following structural formulas: 。 5. The method for electrochemical synthesis of chalcone compounds according to any one of claims 1-4, characterized in that, The molar ratio of compound A, compound B and tert-butyl hydroperoxide is 2.5-3.5:1.5-2.5:1, preferably 3:2:
1.
6. The method for electrochemical synthesis of chalcone compounds according to any one of claims 1-5, characterized in that, The electrolyte is selected from one or more of tetrabutylammonium hexafluorophosphate, lithium perchlorate, or tetrabutylammonium tetrafluoroborate; And / or, the C1-C4 carboxylic acids are selected from one or more of formic acid, acetic acid, propionic acid, and butyric acid; And / or, the mass ratio of compound A to electrolyte solution is 3:140-160; And / or, in the electrolyte solution, the mass ratio of C1-C4 carboxylic acids to water is 1:5 to 4:1; And / or, the molar concentration of the electrolyte in the solvent is 0.05-0.3M.
7. The method for electrochemical synthesis of chalcone compounds according to any one of claims 1-6, characterized in that, The electrolytic reaction is carried out in a single-chamber electrolytic cell under an inert or nitrogen atmosphere.
8. The method for electrochemical synthesis of chalcone compounds according to any one of claims 1-7, characterized in that, The anode of the electrochemical reaction is a platinum electrode, a graphite electrode, or a glassy carbon electrode. And / or, the cathode of the energized reaction is a platinum electrode, a copper electrode, a silver electrode, or a nickel electrode.
9. The method for electrochemical synthesis of chalcone compounds according to any one of claims 1-8, characterized in that, The electrochemical reaction is carried out at room temperature for 1 to 4 hours.
10. The method for electrochemical synthesis of chalcone compounds according to any one of claims 1-9, characterized in that, The electrolysis reaction is carried out under constant potential conditions, and the electrolysis voltage is 1.0V to 1.5V, preferably 1.1V to 1.3V.