Bio-based efficient film-forming carrier for dissolving and stripping open and closed acnes and preparation method of bio-based efficient film-forming carrier

Abstract

The invention provides a bio-based efficient film-forming carrier for dissolving and stripping open and closed acnes, which is prepared from the following raw materials in percentage by weight: at least a phase A, a phase B and a phase C. The phase A at least comprises 0.1-1% of microcrystalline cellulose, 0.15-1% of cellulose gum, 3-8% of aureobasidium pullulans polysaccharide, 10-20% of alkaline blackhead exporting liquid, 2-5% of tromethamine and 30-80.25% of water; the phase B at least comprises 1-10% of caprylic / capric triglyceride and 0.5-5% of lauryl glucoside, and the phase C at least comprises 1-15% of cassava starch and 2-5% of 1, 2-pentanediol; the preparation method has the advantages that the reproducible bacterial nano cellulose is used as microcrystalline cellulose, so that a film forming system for dissolving and stripping open and closed acnes is milder and more effective, secondary injury to skin is avoided, and the film forming system is biodegradable, green and sustainable; the invention also provides a preparation method of the bio-based efficient film-forming carrier.

Description

[0001] This invention relates to the field of skincare technology, specifically to a bio-based high-efficiency film-forming carrier for dissolving and exfoliating open and closed comedones, and its preparation method. Background Technology

[0002] Open comedones and closed comedones are common skin problems, often appearing on the face, chest, and back. Open comedones are caused by the hair follicle and sebaceous gland being blocked by keratin and sebum, but the opening is open to the outside, appearing as small black dots on the surface. Closed comedones are caused by the hair follicle and sebaceous gland opening being blocked by keratinocytes, filled with keratin and sebum, and not open to the outside, appearing as raised whiteheads on the surface. If open and closed comedones are not treated, they may cause skin acne, and in severe cases, they may lead to skin diseases such as acne. Currently, the methods for removing comedones include acid peeling, peeling masks, or direct hand squeezing. Acid peeling and direct hand squeezing will cause secondary damage to the skin, making the skin sensitive, inducing inflammation, and causing pores to expand, making it easier for oil to be deposited again and further damaging the skin. The main component of the film-forming agent of traditional peeling masks is polyvinyl alcohol. The main disadvantages are: (1) chemical raw materials; (2) environmental pollution and unsustainability; (3) not breathable: PVA film has excellent barrier properties against oxygen, nitrogen, hydrogen, helium, argon and carbon dioxide. Under normal pressure, the barrier rate against oxygen is about 1000 times that of commonly used polyethylene film and 300 times that of polypropylene film; (4) not resistant to acids and alkalis: strong alkalis, strong acids, chlorine free radicals and other substances that can react chemically with PVA; (5) after forming a film on the skin, blackheads are completely removed by adhesion and peeling, which damages the skin barrier. Peeling is painful and has a poor experience.

[0003] Bacterial cellulose (BC) was first discovered in 1886 by the British scientist Brown. While culturing Acetobacter under static conditions, he observed a white, gel-like film forming on the surface of the culture medium. Analysis confirmed its composition as cellulose, with fibers at the nanometer scale, hence the name bacterial nanocellulose (BNC). While bacteria capable of producing cellulose include Acetobacter, Agrobacterium, Rhizobium, and Sarcinia, the most studied and highest-producing bacterium is *Acetobacter xylinus*, now renamed *Gluconacetobacter xylinus*. Because bacterial nanocellulose is chemically similar to plant cellulose but has superior performance, its applications in medicine, drug delivery systems, cosmetics, and food are increasingly favored. In the biomedical field, bacterial nanocellulose is mainly used in tissue transplantation, such as in artificial skin, blood vessels, wound dressings, and drug delivery agents in bone tissue. In environmental protection, bacterial nanocellulose can be used as membrane filters to separate various entities, namely microorganisms, organic pollutants, and metal cations, from polluted water. In the food industry, bacterial nanocellulose can be used in the production of natural colorants and thickeners. Compared to plant biomass as a source of cellulose, cellulose produced using microorganisms has excellent properties such as high water retention, high degree of polymerization, high crystallinity, high purity, good biocompatibility, and high mechanical strength.

[0004] Therefore, it is crucial to develop a method for cleaning acne that is minimally irritating to the skin, does not cause secondary skin damage, and is made of biodegradable, green, and sustainable materials. Summary of the Invention

[0005] To overcome the shortcomings of existing technologies and to prepare a highly efficient and rapid skin care product for dissolving and exfoliating acne without causing secondary damage to the skin, and with biodegradable and sustainable materials, this invention provides a bio-based high-efficiency film-forming carrier for dissolving and exfoliating open and closed comedones. The raw materials for preparing the bio-based high-efficiency film-forming carrier, by weight percentage, include at least phase A, phase B, and phase C, wherein: The raw materials for preparing phase A include, by percentage, at least 0.1-1% microcrystalline cellulose, 0.15-1% cellulose gum, 3-8% sprouting short stem enzyme polysaccharide, 10-20% alkaline blackhead removal solution, 2-5% tromethamine, and 30-80.25% water; the microcrystalline cellulose is renewable bacterial nanocellulose. The alkaline blackhead removal solution is prepared by weight percentage and includes at least 3-20% polyol, 0.02-0.12% penetration enhancer, 0.07-1.5% nanomicelles, 0.05-30% plant active ingredients, 0.5-5% pH adjuster, and 56.62-96.36% water. The raw materials for preparing phase B include, by percentage, at least 1-10% caprylic / capric triglycerides and 0.5-5% lauryl glucoside; The raw materials for preparing the C phase include at least 1-15% cassava starch and 2-5% 1,2-pentanediol by percentage.

[0006] Furthermore, the bacterial nanocellulose is composed of highly crystalline cellulose and has high water retention capacity, porosity, high purity, ultra-fine processing capability, and stretchability.

[0007] Furthermore, the bacterial nanocellulose is a polysaccharide biomaterial with a fiber diameter of 20-40 nm and a length of more than 20 micrometers, formed by glucose monomers linked by β-1,4 glycosidic bonds.

[0008] Furthermore, the bacterial nanocellulose has a nanoscale three-dimensional network structure, which has the functions of strong water retention capacity, uniform distribution without changing the liquid viscosity, and efficient bio-based transport carrier.

[0009] Furthermore, the bacterial nanocellulose is free of pectin, hemicellulose, and lignin, making it a safe and natural option for skin repair.

[0010] Further, the polyols include glycerol, 3-propanediol, butylene glycol, dipropylene glycol, and 2,3-butanediol; the penetration enhancers include menthol, borneol, lauroylimino dipropylene glycol, and ethanol; the nanomicelles include polyglycerol-6 polyricinoleate, phytosterols, sodium polyglutamate, phosphatidylcholine, lecithin, azelaic acid MEA, and ethoxydiethylene glycol; the plant active ingredients include *Inonotus obliquus* extract, *Sapona officinalis* root extract, *Arctium lappa* root extract, *Hamamelis virginiana* water, *Lentinus edodes* mycelium extract, *Codonopsis lanchoe* root extract, *Salix alba* bark extract, and *Viscum chinensis*. The extracts include: ALBUM leaf extract, Lavender (LAVANDULA ANGUSTIFOLIA) flower extract, Chrysanthemum sinense flower extract, Glycyrrhiza uralensis root extract, Vaccinium myrtillius leaf extract, Schisandra chinensis fruit extract, Portulaca oleracea extract, Fucus vesculosus extract, Chamomilla recutita flower extract, and Centella asiatica extract; the pH adjusters mainly include arginine and tromethamine.

[0011] This invention also provides a method for preparing a bio-based, highly efficient film-forming carrier for dissolving and exfoliating open and closed comedones, comprising the following steps: S1: Preparation method of phase A: Weigh 8g of water, add the weighed sprouting short stem enzyme polysaccharide while stirring, stir evenly, add the weighed alkaline blackhead removal liquid and tromethamine, stir evenly, add the weighed microcrystalline cellulose and cellulose gum, continue stirring, and when the temperature reaches 75 degrees Celsius, set aside for use; S2: Preparation method of phase B: Mix the weighed caprylic / capric triglyceride and lauryl glucoside evenly and set aside; S3: Preparation method of the C phase: Mix the weighed cassava starch and the 1,2-pentanediol evenly and set aside; S4: Pour phase B into phase A, homogenize with a homogenizer for 1 minute, and set aside; S5: The mixture from step S4 is stirred and cooled to 40 degrees Celsius, the C phase is added, and the pH is not adjusted. Stirring is continued and the mixture is cooled to room temperature. The resulting material is the bio-based high-efficiency film-forming carrier.

[0012] Furthermore, the homogenizer operates at a speed of 12,000 rpm.

[0013] Compared with existing technologies, this invention provides a bio-based high-efficiency film-forming carrier for dissolving and exfoliating open and closed comedones. The raw materials for preparation include at least phase A, phase B, and phase C by weight percentage. Phase A includes at least 0.1-1% microcrystalline cellulose, 0.15-1% cellulose gum, 3-8% sprouting short stem enzyme polysaccharide, 10-20% alkaline blackhead removal solution, 2-5% tromethamine, and 30-80.25% water. Phase B includes at least 1-10% caprylic / capric triglyceride and 0.5-5% lauryl glucoside. Phase C includes at least 1-15% tapioca starch and 2-5% 1,2-pentanediol. By using renewable bacterial nanocellulose as microcrystalline cellulose, the film-forming system for dissolving and exfoliating open and closed comedones is gentler and more effective, without causing secondary damage to the skin. Furthermore, this film-forming system is biodegradable and green and sustainable. Attached Figure Description

[0014] To more clearly illustrate the technical solutions in the embodiments of the present invention, the background technology and the drawings used in the embodiments will be briefly introduced below. Obviously, the drawings used in the embodiments described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0015] Figure 1 This is a schematic diagram of the raw material composition for preparing a bio-based high-efficiency film-forming carrier for dissolving and peeling open and closed acne, provided by an embodiment of the present invention.

[0016] Figure 2 This is a flowchart of a method for preparing a bio-based high-efficiency film-forming carrier for dissolving and peeling open and closed comedones, provided by an embodiment of the present invention.

[0017] Figure 3 This is a schematic diagram of the molecular structure of bacterial nanocellulose, a bio-based high-efficiency film-forming carrier for dissolving and peeling open and closed acne, provided by an embodiment of the present invention.

[0018] Figure 4 This is a schematic diagram of a three-dimensional water-locking structure of bacterial nanocellulose, a bio-based high-efficiency film-forming carrier for dissolving and peeling open and closed comedones, provided by an embodiment of the present invention.

[0019] Figure 5This is a schematic diagram of applying an appropriate amount of a bio-based high-efficiency film-forming carrier to the skin for dissolving and peeling open and closed acne, as provided in an embodiment of the present invention.

[0020] Figure 6 This is a schematic diagram of a bio-based high-efficiency film-forming carrier for dissolving and peeling open and closed acne, provided by an embodiment of the present invention, in which the film-forming carrier is evenly spread 1-3 mm.

[0021] Figure 7 This is a diagram illustrating the film-forming effect of a bio-based high-efficiency film-forming carrier for dissolving and peeling open and closed comedones, provided by an embodiment of the present invention. Figure 8 This is a schematic diagram of the nasal area of ​​a volunteer before use of a bio-based high-efficiency film-forming carrier for dissolving and peeling open and closed comedones, provided in an embodiment of the present invention.

[0022] Figure 9 This is a schematic diagram of a volunteer applying a bio-based, highly efficient film-forming carrier for dissolving and peeling open and closed comedones to the nose area, as provided in an embodiment of the present invention.

[0023] Figure 10 This is a schematic diagram of the nasal area after a volunteer removes a bio-based, highly efficient film-forming carrier for dissolving and peeling open and closed comedones, as provided in an embodiment of the present invention.

[0024] Figure 11 This is a schematic diagram of a bio-based high-efficiency film-forming carrier for dissolving and peeling open and closed comedones, as provided in an embodiment of the present invention, showing the removal of the film-forming carrier by volunteers. Detailed Implementation

[0025] To make the objectives, technical solutions, and advantages of this invention clearer, the invention will be further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative and not intended to limit the invention.

[0026] In the accompanying drawings of this embodiment, the same or similar reference numerals correspond to the same or similar components. In the description of this invention, it should be understood that if terms such as "upper," "lower," "left," and "right" indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, they are only for the convenience of describing this invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, the terms used to describe positional relationships in the drawings are only for illustrative purposes and should not be construed as limiting this invention. For those skilled in the art, the specific meaning of the above terms can be understood according to the specific circumstances.

[0027] The technical solution of the present invention will be described in detail below with reference to the accompanying drawings and specific embodiments.

[0028] The present invention provides a bio-based high-efficiency film-forming carrier for dissolving and exfoliating open and closed comedones, as described above. Figure 1 The raw materials for preparing the bio-based high-efficiency film-forming carrier include, by weight percentage, at least phase A, phase B, and phase C, wherein: The raw materials for preparing phase A include, by percentage, at least 0.1-1% microcrystalline cellulose, 0.15-1% cellulose gum, 3-8% sprouting short stem enzyme polysaccharide, 10-20% alkaline blackhead removal solution, 2-5% tromethamine, and 30-80.25% water; the microcrystalline cellulose is renewable bacterial nanocellulose; The raw materials for preparing alkaline blackhead removal solution include, by weight percentage, at least 3-20% polyol, 0.02-0.12% penetration enhancer, 0.07-1.5% nanomicelles, 0.05-30% plant active ingredients, 0.5-5% pH adjuster, and 56.62-96.36% water; The raw materials for preparing phase B include, by percentage, at least 1-10% caprylic / capric triglycerides and 0.5-5% lauryl glucoside; The raw materials for the preparation of phase C include at least 1-15% cassava starch and 2-5% 1,2-pentanediol by percentage. This invention also provides a method for preparing a bio-based high-efficiency film-forming carrier, comprising the following steps: S1: A phase preparation method: Weigh 8g of water, add the weighed sprouting short stem enzyme polysaccharide while stirring, stir evenly, add the weighed alkaline blackhead removal liquid and the tromethamine, stir evenly, add the weighed microcrystalline cellulose and cellulose gum, continue stirring, and when the temperature reaches 75 degrees Celsius, set aside for use. S2: B phase preparation method: Mix the weighed caprylic / capric triglyceride and lauryl glucoside evenly and set aside; S3: C phase preparation method: Mix the weighed tapioca starch and 1,2-pentanediol evenly and set aside; S4: Pour phase B into phase A, homogenize with a homogenizer for 1 minute, and set aside; S5: Stir and cool the mixture from step S4 to 40 degrees Celsius, add phase C, continue stirring without adjusting pH and cooling to room temperature, and discharge to obtain the bio-based high-efficiency film-forming carrier.

[0029] The above technical solution provides a bio-based high-efficiency film-forming carrier for dissolving and exfoliating open and closed comedones. The raw materials, by weight percentage, include at least phase A, phase B, and phase C. Phase A includes at least 0.1-1% microcrystalline cellulose, 0.15-1% cellulose gum, 3-8% sprouting stalk enzyme polysaccharide, 10-20% alkaline blackhead removal solution, 2-5% tromethamine, and 30-80.25% water. Phase B includes at least 1-10% caprylic / capric triglyceride and 0.5-5% lauryl glucoside. Phase C includes at least 1-15% tapioca starch and 2-5% 1,2-pentanediol. Compared with existing technologies, this invention uses renewable bacterial nanocellulose as microcrystalline cellulose, making the film-forming system for dissolving and exfoliating open and closed comedones gentler and more effective, without causing secondary damage to the skin. Furthermore, this film-forming system is biodegradable and environmentally sustainable. This invention also provides a method for preparing the bio-based high-efficiency film-forming carrier.

[0030] As one embodiment of the present invention, bacterial nanocellulose is composed of highly crystalline cellulose and has high water retention capacity, porosity, high purity, ultra-fine processing and stretchability.

[0031] As one embodiment of the present invention, such as Figure 3 As shown, bacterial nanocellulose is a polysaccharide biomaterial with a fiber diameter of 20-40 nm and a length of more than 20 micrometers, formed by glucose monomers linked by β-1,4 glycosidic bonds.

[0032] As one embodiment of the present invention, such as Figure 4 As shown, bacterial nanocellulose has a nanoscale three-dimensional network structure, which has the functions of strong water retention capacity, uniform distribution without changing the liquid viscosity, and efficient bio-based transport carrier.

[0033] As one embodiment of the present invention, bacterial nanocellulose is free of pectin, hemicellulose and lignin, making it a safe and green method for skin repair.

[0034] As one embodiment of the present invention, the polyols include glycerol, 3-propanediol, butylene glycol, dipropylene glycol, and 2,3-butanediol; the penetration enhancers include menthol, borneol, lauroylimino dipropylene glycol, and ethanol; the nanomicelles include polyglycerol-6 polyricinoleate, phytosterols, sodium polyglutamate, phosphatidylcholine, lecithin, azelaic acid MEA, and ethoxydiethylene glycol; the plant active ingredients include *Inonotus obliquus* extract, *Sapona officinalis* root extract, *Arctium lappa* root extract, *Hamamelis virigina* water, *Lentinus edodes* mycelium extract, *Codonopsis lanchoe* root extract, *Salixa alba* bark extract, and *Viscum album*. ALBUM leaf extract, Lavender (LAVANDULA ANGUSTIFOLIA) flower extract, Chrysanthemum sinense flower extract, Glycyrrhiza (GLYCYRRHIZAURALENSIS) root extract, Vaccinium (VACCINIUM MYRTILLUS) leaf extract, Schisandra chinensis (SCHISANDRA CHINENSIS) fruit extract, Portulaca oleracea extract, Fucus vesicola (FUCUS VESCULOSUS) extract, Chamomilla recutita (CHAMOMILLA RECUTITA) flower extract, Centella asiatica (CENTELLA ASIATICA) extract; pH adjusters mainly include arginine and tromethamine.

[0035] As an embodiment of the present invention, the alkaline blackhead removal solution is prepared as follows: 1. Using high-pressure microfluidic technology and high-performance surfactant raw materials, ultrafine nano micelles are prepared; 2. Extracting active plant components; 3. Finally, mix them together to form the final product.

[0036] In one embodiment of the present invention, the homogenizer speed is 12000 rpm.

[0037] Film formation verification: Apply an appropriate amount of the bio-based high-efficiency film-forming carrier to the skin and spread it evenly to a thickness of 1-3 mm. Figure 5 As shown; After 15-20 minutes, the bio-based high-efficiency film-forming carrier will form a film, such as... Figure 6 As shown; Gently peel off the bio-based high-efficiency film-forming carrier and observe its film-forming properties, such as... Figure 7 As shown.

[0038] Efficacy test: 1. Human testing: Ten volunteers aged 16-35 years with obvious blackheads on their noses were selected. The subjects should not be sensitive to commonly used cosmetics and should not have participated in other clinical trials in the past week. The skin image analyzer VISIA-CR (Canfield, USA) was used to test (Hue value, the lower the value, the better).

[0039] 2. Test Method: Subjects were asked to sit quietly for 15 minutes in the test environment (room temperature controlled at 21℃, relative humidity at 40%), and their faces were photographed. A 42℃ hot towel was applied to the nose for 5 minutes. The bio-based high-efficiency film-forming carrier was then applied to the test area of ​​the nose, with a thickness of approximately 1-3 mm. After 15 minutes, the film formed by the bio-based high-efficiency film-forming carrier was removed, and the changes in sebum (Hue value) in the volunteer's test area were scanned using a skin image analyzer VISIA-CR (Canfield, USA).

[0040] 3. Test Results: Before using the bio-based high-efficiency film-forming carrier, volunteers had obvious sebum secretion in the nasal area, and visible whiteheads / blackheads were also present. Figure 8 As shown; the bio-based high-efficiency film-forming carrier was evenly applied to the volunteer's nasal area, as... Figure 9 As shown; after 15 minutes, the membrane formed by the bio-based high-efficiency membrane-forming carrier was peeled off. Visibly overflowing sebum and previously visible whiteheads / blackheads had been dissolved and removed along with the membrane. Figure 10 As shown; the peeled membrane contains visible white sebum and skin flakes, which are metabolic products. Figure 11 As shown in Table 1, the changes in sebum in 10 volunteers show that the average sebum reduction before and after use was 5.53%, indicating that the bio-based high-efficiency film-forming carrier has a good sebum-dissolving effect.

[0041] Table 1 Mildness test: Human testing: Ten volunteers aged 16-35 years with obvious blackheads on their noses were selected. The participants were not sensitive to commonly used cosmetics and had not participated in other clinical trials in the past week. The skin image analyzer VISIA-CR (Canfield, USA) was used for testing.

[0042] Test method: Subjects were asked to sit quietly for 15 minutes in the test environment (room temperature controlled at 21℃, relative humidity 40%), take photos of their faces, apply a 42℃ hot towel to the nose for 5 minutes, apply the bio-based high-efficiency film-forming carrier to the test area of ​​the nose, and after 15 minutes, remove the bio-based high-efficiency film-forming carrier. The redness value of the volunteer's test area was scanned using a skin image analyzer VISIA-CR (Canfield, USA) to observe the gentleness of the system on the skin.

[0043] Test results: Subjects self-assessed that 100% experienced no discomfort after use and no pain upon tearing; Table 2 shows the changes in the red area before and after use in 10 volunteers. It can be seen that the average change rate of the red area was 0.013%, indicating that the bio-based high-efficiency film-forming carrier has good gentleness on the skin.

[0044] Table 2 The embodiments of the present invention have been described in detail above, but the invention is not limited to these embodiments. Those skilled in the art can make many equivalent modifications or substitutions without departing from the spirit of the invention, and these equivalent modifications or substitutions are all included within the protection scope defined by the claims of this application.

Claims

1. A bio-based high-efficiency film-forming vehicle for dissolving and exfoliating open and closed comedones, characterized in that, The raw materials for preparing the bio-based high-efficiency film-forming carrier include, by weight percentage, at least phase A, phase B, and phase C, wherein: The raw materials for preparing phase A include, by percentage, at least 0.1-1% microcrystalline cellulose, 0.15-1% cellulose gum, 3-8% sprouting short stem enzyme polysaccharide, 10-20% alkaline blackhead removal solution, 2-5% tromethamine, and 30-80.25% water; the microcrystalline cellulose is renewable bacterial nanocellulose. The alkaline blackhead removal solution is prepared by weight percentage and includes at least 3-20% polyol, 0.02-0.12% penetration enhancer, 0.07-1.5% nanomicelles, 0.05-30% plant active ingredients, 0.5-5% pH adjuster, and 56.62-96.36% water. The raw materials for preparing phase B include, by percentage, at least 1-10% caprylic / capric triglycerides and 0.5-5% lauryl glucoside; The raw materials for preparing the C phase include, by percentage, at least 1-15% cassava starch and 2-5% 1,2-pentanediol; The preparation method of the bio-based high-efficiency film-forming carrier includes the following steps: S1: Preparation method of phase A: Weigh 8g of water, add the weighed sprouting short stem enzyme polysaccharide while stirring, stir evenly, add the weighed alkaline blackhead removal liquid and tromethamine, stir evenly, add the weighed microcrystalline cellulose and cellulose gum, continue stirring, and when the temperature reaches 75 degrees Celsius, set aside for use; S2: Preparation method of phase B: Mix the weighed caprylic / capric triglyceride and lauryl glucoside evenly and set aside; S3: Preparation method of the C phase: Mix the weighed cassava starch and the 1,2-pentanediol evenly and set aside; S4: Pour phase B into phase A, homogenize with a homogenizer for 1 minute, and set aside; S5: The mixture from step S4 is stirred and cooled to 40 degrees Celsius, the C phase is added, and the pH is not adjusted. Stirring is continued and the mixture is cooled to room temperature. The resulting material is the bio-based high-efficiency film-forming carrier.

2. The bio-based high-performance film forming vehicle of claim 1, wherein, The bacterial nanocellulose is composed of highly crystalline cellulose and has high water retention capacity, porosity, high purity, ultra-fine processing and stretchability.

3. The bio-based high-efficiency film-forming carrier according to claim 1, characterized in that, The bacterial nanocellulose is a polysaccharide biomaterial with a fiber diameter of 20-40 nm and a length of more than 20 micrometers, formed by glucose monomers linked by β-1,4 glycosidic bonds.

4. The bio-based high-efficiency film-forming carrier according to claim 1, characterized in that, The bacterial nanocellulose has a nanoscale three-dimensional network structure, which has the functions of strong water retention capacity, uniform distribution without changing the viscosity of the liquid, and efficient transport carrier based on biotechnology.

5. The bio-based high-efficiency film-forming carrier according to claim 1, characterized in that, The bacterial nanocellulose contains no pectin, hemicellulose, or lignin, making it a safe and natural way to repair skin.

6. The bio-based high-efficiency film-forming carrier according to claim 1, characterized in that, The polyols include glycerol, 3-propanediol, butylene glycol, dipropylene glycol, and 2,3-butanediol; the penetration enhancers include menthol, borneol, lauroylimino dipropylene glycol, and ethanol; the nanomicelles include polyglycerol-6 polyricinoleate, phytosterols, sodium polyglutamate, phosphatidylcholine, lecithin, azelaic acid MEA, and ethoxydiethylene glycol; the plant active ingredients include Inonotus obliquus extract, Soapwort root extract, burdock root extract, witch hazel water, Lentinus edodes mycelium extract, sheep milk root extract, white willow bark extract, mistletoe leaf extract, lavender flower extract, Chrysanthemum morifolium flower extract, licorice root extract, Vaccinium bracteatum leaf extract, Schisandra chinensis fruit extract, Portulaca oleracea extract, Fucus veitchii extract, Matricaria champaca flower extract, and Centella asiatica extract; the pH adjusters mainly include arginine and tromethamine.

7. The method for preparing the bio-based high-efficiency film-forming carrier according to claim 1, characterized in that, The homogenizer operates at a speed of 12,000 rpm.

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