Oral drug fixed-point release capsule and visual drug release system

Abstract

The invention discloses an oral drug fixed-point release capsule and a visual drug release system, and relates to the field of oral capsules. According to the oral medicine fixed-point release capsule and the visual medicine release system, through the arrangement of the shell, the first sealing head, the second sealing head, the auxiliary clamping piece, the medicine pushing assembly and the positioning control assembly, medicine is loaded in the medicine cabin, after a patient orally takes the capsule, the positioning control assembly collects acid-base information in real time and transmits the acid-base information outwards, and then the medicine is released through the auxiliary clamping piece. The external control terminal judges the position of the capsule in the digestive system according to the acid-base information, and when the capsule reaches a designated position, the positioning control assembly receives and executes a drug release control instruction, triggers the drug pushing assembly and the auxiliary clamping piece to act, opens the second sealing head and pushes the drug out of the drug cabin, so that the drug acts at the designated position of the digestive system.

Description

Technical Field

[0001] This invention relates to oral capsule technology, specifically to an oral drug targeted release capsule and a visualized drug release system. Background Technology

[0002] Many drugs are destroyed and rendered ineffective in the highly acidic gastric juices, such as protein drugs and certain antibiotics. In order for oral drugs to reach specific tissues and exert their effects smoothly, they can be encapsulated in enteric-coated capsules, which can ensure that the drugs safely reach the intestines and are effectively absorbed.

[0003] However, existing capsule drugs need to pass through tissues such as the esophagus, stomach, small intestine, large intestine, and colon. Although the drug can reach some designated locations and dissolve and release the drug by relying on the capsule coating, the acid-base environment of the entire digestive system varies. The difference in acid-base environment places high demands on the preparation technology of the capsule coating. Even if some drugs that need to act in the later part of the digestive system are wrapped in a capsule coating, it is difficult for the drug as a whole to reach the designated location and act relatively intact. It is difficult to control the drug in the digestive system. Therefore, it is necessary to design a drug delivery carrier that can carry the drug to the designated location in the digestive system for release and action. Summary of the Invention

[0004] The purpose of this invention is to provide an oral drug targeted release capsule and a visualized drug release system to solve the problem that existing capsule encapsulation technology is difficult to flexibly control the release of drugs at a designated location in the digestive system.

[0005] To achieve the above objectives, the present invention provides the following technical solution: an oral drug targeted release capsule, comprising:

[0006] The outer casing has a first sealing head connected to one end and a second sealing head connected to the other end. A mobile power supply is installed inside the first sealing head.

[0007] An auxiliary snap-fit ​​component, disposed in the housing, is used to assist in connecting the second sealing head to the housing and to separate the second sealing head from the housing after triggering. It consists of a first mounting plate connected in the housing and an energy storage telescopic component connected between the first mounting plate and the second sealing head.

[0008] The drug delivery assembly, disposed in the housing, includes a mounting bracket connected to the housing, a micro motor connected to the mounting bracket, and a lead screw connected to the output shaft of the micro motor. A push plate that slides along the length of the housing is threaded onto the lead screw, and a drug compartment is configured between the push plate and the second sealing head.

[0009] A positioning control component is disposed between the first sealing head and the outer shell. It is used to position the outer shell, generate a drug release command based on the positioning information and set trigger conditions, and control the drug pushing component and auxiliary card connector to execute the drug release command.

[0010] Preferably, the energy storage telescopic component includes a slide cylinder connected to the first mounting plate and a lifting rod slidably connected in the slide cylinder. One end of the lifting rod extends out of the slide cylinder and is connected to a second sealing head. A lower baffle is connected to the inner wall of the slide cylinder, and an upper baffle is connected to the lifting rod. A spring is sleeved on the lifting rod, with the upper end of the spring abutting against the upper baffle and the lower end abutting against the lower baffle. A curved rod is connected to the end of the lifting rod, and a locking block is connected to the end of the curved rod.

[0011] Preferably, the push plate is slidably connected to the slide cylinder, and the side wall of the push plate abuts against the inner wall of the outer casing.

[0012] Preferably, the locking block is disposed on the side of the crank rod near the lead screw, and the side of the locking block near the lead screw is arc-shaped, with a rotating rod connected to the lead screw.

[0013] Preferably, the positioning control component includes a second mounting plate connected inside the first sealing head, the mobile power supply is connected to the second mounting plate, and a control module is also connected to the second mounting plate. The control module includes a motherboard, a computing chip, a memory and a wireless connection module. A pH probe is connected to the control module, and the end of the pH probe passes through the first sealing head and extends to the outside of the first sealing head.

[0014] Preferably, the first sealing head is threadedly connected to the outer shell, and the second sealing head is snapped into the outer shell.

[0015] Preferably, the outer shell, the first sealing head, and the second sealing head are arranged in a granular capsule shape.

[0016] Preferably, the outer shell, the first sealing head, and the second sealing head are made of rigid engineered silk fibroin or nickel-titanium alloy.

[0017] A visualized drug delivery system, comprising:

[0018] The execution end, such as a targeted release capsule for oral drugs, is used to carry the drug, collect and transmit the environmental pH value, receive drug release control instructions, and execute the drug release control instructions to release the drug;

[0019] Control terminal:

[0020] The data receiving and communication module is used to continuously receive real-time pH data streams from the execution end and send drug release control commands to the execution end;

[0021] The position algorithm and decision module is used to smooth the pH data stream and extract features, determine the real-time positioning of the execution end, and automatically generate drug release control instructions when the real-time position of the execution end reaches the preset treatment target position.

[0022] The user interaction and visualization interface module is used to display the real-time location and pH environment of the execution terminal in the form of charts and simulation animations, and supports preset drug release location and activation time of the execution terminal.

[0023] The data storage and management module is used to completely record all data from the treatment process.

[0024] Compared with existing technologies, the present invention provides an oral drug targeted release capsule and a visualized drug release system. By setting up a shell, a first sealing head, a second sealing head, an auxiliary locking component, a drug pushing component, and a positioning control, the drug is loaded in the drug compartment. After the patient takes the capsule orally, the positioning control component collects acid-base information in real time and transmits this information externally. An external control terminal determines the capsule's position in the digestive system based on the acid-base information. When the capsule reaches the designated position, the positioning control component receives and executes a drug release control command, triggering the drug pushing component and the auxiliary locking component to open the second sealing head and push the drug out of the drug compartment, allowing the drug to act at the designated location in the digestive system. Attached Figure Description

[0025] To more clearly illustrate the technical solutions in the embodiments of this application or the prior art, the drawings used in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments recorded in this invention. For those skilled in the art, other drawings can be obtained based on these drawings.

[0026] Figure 1 A schematic diagram of the overall sealing structure provided in an embodiment of the present invention;

[0027] Figure 2 This is a schematic diagram of the overall open structure provided in an embodiment of the present invention;

[0028] Figure 3 A schematic diagram of the overall cross-sectional structure provided for an embodiment of the present invention. Figure 1 ;

[0029] Figure 4 A schematic diagram of the overall cross-sectional structure provided for an embodiment of the present invention. Figure 2 ;

[0030] Figure 5 Provided for embodiments of the present invention Figure 4 Enlarged view of part A in the middle;

[0031] Figure 6This is a schematic diagram of the rotating rod working structure provided in an embodiment of the present invention.

[0032] Explanation of reference numerals in the attached figures:

[0033] 1. Outer shell; 2. First sealing head; 3. Second sealing head; 4. Mounting bracket; 5. Micro motor; 6. Lead screw; 7. First mounting plate; 8. Slide cylinder; 9. Lifting rod; 10. Lower baffle; 11. Upper baffle; 12. Spring; 13. Crank rod; 14. Locking block; 15. Second mounting plate; 16. Power supply; 17. Control module; 18. pH probe; 19. Push plate; 20. Rotating rod. Detailed Implementation

[0034] To enable those skilled in the art to better understand the technical solution of the present invention, the present invention will be further described in detail below with reference to the accompanying drawings.

[0035] As attached Figure 1 To be continued Figure 6 As shown:

[0036] Example:

[0037] This invention provides an oral drug targeted release capsule, comprising:

[0038] The outer shell 1 has a first sealing head 2 connected to one end and a second sealing head 3 connected to the other end. A mobile power supply 16 is provided inside the first sealing head 2. The first sealing head 2 is threadedly connected to the outer shell 1, and the second sealing head 3 is snapped into the outer shell 1. The outer shell 1, the first sealing head 2 and the second sealing head 3 are arranged in a granular capsule shape.

[0039] An auxiliary snap-fit ​​component, disposed in the housing 1, is used to assist in connecting the second sealing head 3 to the housing 1 and to separate the second sealing head 3 from the housing 1 after triggering. It consists of a first mounting plate 7 connected in the housing 1 and an energy storage telescopic component connected between the first mounting plate 7 and the second sealing head 3.

[0040] The drug pushing assembly, disposed in the housing 1, includes a mounting bracket 4 connected to the housing 1, a micro motor 5 connected to the mounting bracket 4, and a lead screw 6 connected to the output shaft of the micro motor 5. A push plate 19 that slides along the length direction of the housing 1 is threaded onto the lead screw 6. A drug compartment is configured between the push plate 19 and the second sealing head 3. When the micro motor 5 drives the lead screw 6 to rotate, the lead screw 6 drives the push plate 19 to move inside the housing 1, thereby pushing out the drug in the drug compartment.

[0041] A positioning control component is disposed between the first sealing head 2 and the outer shell 1, for positioning the outer shell 1, for collecting acid-base information and receiving and executing drug release control commands.

[0042] As can be seen from the above, by setting up the outer shell 1, the first sealing head 2, the second sealing head 3, the auxiliary card connector, the drug pushing component, and the positioning control component, the drug is loaded in the drug compartment. After the patient takes the capsule orally, the positioning control component collects acid-base information in real time and transmits the acid-base information outward. The external control terminal determines the position of the capsule in the digestive system based on the acid-base information. When the capsule reaches the designated position, the positioning control component receives and executes the drug release control command, triggering the drug pushing component and the auxiliary card connector to open the second sealing head 3 and push the drug out of the drug compartment, so that the drug acts at the designated position in the digestive system.

[0043] The energy storage telescopic component includes a slide cylinder 8 connected to the first mounting plate 7 and a lifting rod 9 slidably connected in the slide cylinder 8. One end of the lifting rod 9 extends out of the slide cylinder 8 and is connected to the second sealing head 3. A lower baffle 10 is connected to the inner wall of the slide cylinder 8. An upper baffle 11 is connected to the lifting rod 9. A spring 12 is sleeved on the lifting rod 9, and the upper end of the spring 12 abuts against the upper baffle 11 and the lower end abuts against the lower baffle 10. A curved rod 13 is connected to the end of the lifting rod 9, and a locking block 14 is connected to the end of the curved rod 13.

[0044] After the drug compartment is filled with medication, the second sealing head 3 can be pressed against the outer shell 1. The second sealing head 3 drives the lifting rod 9 and the upper baffle 11 to slide and compress the spring 12 inside the slide cylinder 8. The spring 12 is compressed and shortens to store energy. The sliding lifting rod 9 can also drive the curved rod 13 and the locking block 14 to extend out of the slide cylinder 8. Due to the curved rod 13, the curved rod 13 can drive the locking block 14 to engage with the first mounting plate 7, thereby limiting the sliding tendency of the lifting rod 9. This allows the second sealing head 3 to be stably engaged at the end of the outer shell 1, sealing the drug compartment. After the capsule reaches the designated position in the digestive system, the energy storage telescopic component can be triggered by the drug pushing component. By pushing the locking block 14, the curved rod 13 is bent. When the locking block 14 is pushed to the end of the slide cylinder 8, the compressed spring 12 resets and pushes the upper baffle 11. The upper baffle 11 drives the lifting rod 9 and the curved rod 13 to slide upward and push the second sealing head 3, so that the second sealing head 3 separates from the outer shell 1 and exposes the drug compartment. The medication in the drug compartment is released at the designated position in the fire protection system.

[0045] To facilitate the pusher plate 19 in pushing the medicine out of the capsule as much as possible, the pusher plate 19 is slidably connected to the slide cylinder 8, and the side wall of the pusher plate 19 abuts against the inner wall of the outer shell 1, so as to prevent the medicine from remaining in the medicine capsule through the gaps around the pusher plate 19.

[0046] The locking block 14 is located on the side of the crank 13 near the lead screw 6. The side of the locking block 14 near the lead screw 6 is arc-shaped. A rotating rod 20 is connected to the lead screw 6. When the crank 13 drives the locking block 14 to extend out of the slide cylinder 8, the curved crank 13 can lock the locking block 14 onto the first mounting plate 7. Both locking blocks 14 are close to the lead screw 6. When the positioning control component controls the micro motor 5 and the lead screw 6 to act according to the drug release control command, the micro motor 5 drives the lead screw 6 and the rotating rod 20 to rotate. The rotating rod 20 can push the locking block 14, causing the locking block 14 to separate from the first mounting plate 7 and retract into the slide cylinder 8 under the action of the spring 12 and the crank 13. At this time, the second sealing head 3 opens.

[0047] The positioning control component includes a second mounting plate 15 connected inside the first sealing head 2. The mobile power supply 16 is connected to the second mounting plate 15. A control module 17 is also connected to the second mounting plate 15. The control module 17 includes a motherboard, a computing chip, a memory, and a wireless connection module. A pH probe 18 is connected to the control module 17, and the end of the pH probe 18 passes through the first sealing head 2 and extends to the outside of the first sealing head 2.

[0048] pH probe 18 is the electronic eye of this system, its core function being to sense real-time changes in the pH of the digestive tract environment. It detects hydrogen ion concentration using miniature probes such as glass electrodes and converts the chemical signal into an electrical signal. This sensor boasts extremely high miniaturization, biocompatibility, and corrosion resistance, enabling it to adapt to complex digestive fluid environments. Its continuously measured pH data stream is the sole basis for the backend algorithm's real-time positioning. By identifying characteristic pH ranges and their dynamic trends, such as the strong acidity of the stomach, the near-neutral pH of the small intestine, and the weak acidity of the colon, the system can accurately determine the capsule's location, thereby triggering drug release at the optimal target point and achieving visualized and intelligent control of the drug delivery process.

[0049] The power bank 16 supplies power to the electronic components inside the capsule. The control module 17 receives the electrical signal from the pH probe 18 and transmits it wirelessly to an external terminal. The external terminal processes the electrical signal using an algorithm to determine the capsule's location. Once the capsule reaches the preset location, it generates a drug release control command and transmits it wirelessly to the control module 17. The control module 17 then controls the micro motor 5 to open the second sealing head 3, thereby releasing the drug from the capsule at the set location.

[0050] To enhance the overall corrosion resistance of the capsule while reducing its overall weight, the outer shell 1, the first sealing head 2, and the second sealing head 3 are made of rigid engineered silk fibroin or nickel-titanium alloy.

[0051] A visualized drug delivery system, comprising:

[0052] The execution end, such as a targeted release capsule for oral drugs, is used to carry the drug, collect and transmit the environmental pH value, receive drug release control instructions, and execute the drug release control instructions to release the drug;

[0053] Control terminal:

[0054] The data receiving and communication module is used to continuously receive real-time pH data streams from the execution end and send drug release control commands to the execution end;

[0055] The position algorithm and decision module is used to smooth the pH data stream and extract features, determine the real-time positioning of the execution end, and automatically generate drug release control instructions when the real-time position of the execution end reaches the preset treatment target position.

[0056] The user interaction and visualization interface module is used to display the real-time location and pH environment of the execution terminal in the form of charts and simulation animations, and supports preset drug release location and activation time of the execution terminal.

[0057] The data storage and management module is used to completely record all data from the treatment process.

[0058] The system control terminal is deployed on users' smartphones and other mobile devices in the form of a highly integrated dedicated APP. This APP is not only the control hub but also the interaction portal. When users use the system for the first time, they can scan the unique identification QR code pre-printed on the capsule shell 1 through the APP. This QR code is like the capsule's "digital ID card," containing a unique encrypted ID and pairing key. After scanning, the APP will automatically complete device binding, security verification, and establish an exclusive wireless control connection with the designated capsule. At the same time, the interface clearly displays the capsule number, binding status, and real-time signal strength, ensuring accurate and secure control and full-process visual tracking of "that one" capsule.

[0059] The foregoing has only described certain exemplary embodiments of the present invention by way of illustration. Undoubtedly, those skilled in the art can modify the described embodiments in various ways without departing from the spirit and scope of the present invention. Therefore, the foregoing drawings and descriptions are illustrative in nature and should not be construed as limiting the scope of protection of the claims of the present invention.

Claims

1. An oral drug site-specific release capsule, characterized in that, include: The outer shell (1) has a first sealing head (2) connected to one end and a second sealing head (3) connected to the other end. A mobile power supply (16) is installed inside the first sealing head (2). An auxiliary snap-fit ​​component is provided in the housing (1) to assist in connecting the second sealing head (3) and the housing (1) and to separate the second sealing head (3) and the housing (1) after triggering. It consists of a first mounting plate (7) connected in the housing (1) and an energy storage telescopic component connected between the first mounting plate (7) and the second sealing head (3). The drug delivery assembly is disposed in the housing (1) and includes a mounting bracket (4) connected to the housing (1), a micro motor (5) connected to the mounting bracket (4), and a lead screw (6) connected to the output shaft of the micro motor (5). A push plate (19) that slides along the length direction of the housing (1) is threaded onto the lead screw (6). The push plate (19) and the second sealing head (3) are configured as a drug compartment. The positioning control component is disposed between the first sealing head (2) and the outer shell (1) for positioning the outer shell (1), collecting acid and alkali information and receiving and executing drug release control commands.

2. A site-specific drug release capsule according to claim 1, wherein The energy storage telescopic component includes a slide cylinder (8) connected to the first mounting plate (7) and a lifting rod (9) slidably connected in the slide cylinder (8). One end of the lifting rod (9) extends out of the slide cylinder (8) and is connected to the second sealing head (3). A lower baffle (10) is connected to the inner wall of the slide cylinder (8). An upper baffle (11) is connected to the lifting rod (9). A spring (12) is sleeved on the lifting rod (9). The upper end of the spring (12) abuts against the upper baffle (11), and the lower end abuts against the lower baffle (10). A curved rod (13) is connected to the end of the lifting rod (9). A locking block (14) is connected to the end of the curved rod (13).

3. A site-specific drug release capsule according to claim 2, wherein The push plate (19) is slidably connected to the slide cylinder (8), and the side wall of the push plate (19) abuts against the inner wall of the outer shell (1).

4. A site-specific drug release capsule according to claim 2, wherein The locking block (14) is located on the side of the crank (13) near the lead screw (6). The locking block (14) is arc-shaped on the side of the lead screw (6). A rotating rod (20) is connected to the lead screw (6).

5. The site-specific drug release capsule according to claim 1, wherein The positioning control component includes a second mounting plate (15) connected inside the first sealing head (2), the mobile power supply (16) is connected to the second mounting plate (15), and a control module (17) is also connected to the second mounting plate (15). The control module (17) includes a motherboard, a computing chip, a memory and a wireless connection module. A pH probe (18) is connected to the control module (17), and the end of the pH probe (18) passes through the first sealing head (2) and extends to the outside of the first sealing head (2).

6. A site-specific drug release capsule according to claim 1, wherein The first sealing head (2) is threadedly connected to the outer shell (1), and the second sealing head (3) is snapped into the outer shell (1).

7. A site-specific drug release capsule according to claim 1, wherein The outer shell (1), the first sealing head (2), and the second sealing head (3) are arranged in a granular capsule shape.

8. The oral drug targeted-release capsule according to claim 1, characterized in that, The outer shell (1), the first sealing head (2), and the second sealing head (3) are made of rigid engineered silk fibroin or nickel-titanium alloy.

9. A visual drug delivery system, characterized in that, include: The execution end, as described in any one of claims 1-8, is an oral drug targeted release capsule: used to carry the drug, collect and transmit the environmental pH value, receive the drug release control command, and execute the drug release control command to release the drug; Control terminal: The data receiving and communication module is used to continuously receive real-time pH data streams from the execution end and send drug release control commands to the execution end; The position algorithm and decision module is used to smooth the pH data stream and extract features, determine the real-time positioning of the execution end, and automatically generate drug release control instructions when the real-time position of the execution end reaches the preset treatment target position. The user interaction and visualization interface module is used to display the real-time location and pH environment of the execution terminal in the form of charts and simulation animations, and supports preset drug release location and activation time of the execution terminal. The data storage and management module is used to completely record all data from the treatment process.

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