Medicine for treating arthritis, rheumatism ostalgia and acute muscle injury and preparation method thereof

Abstract

The invention discloses a medicine for treating arthritis, rheumatic bone pain and acute muscle injury and a preparation method thereof. The medicine is prepared from the following components in parts by weight: 5-10 parts of agilawood, 1-10 parts of resina liquidamberis, 1-8 parts of pseudo-ginseng, 1-8 parts of garden balsam stem, 5-15 parts of fructus cnidii, 5-10 parts of cicada slough, 10-20 parts of frankincense, 10-20 parts of mentholum and 5-15 parts of resina draconis. The traditional Chinese medicinal materials adopted in the prescription do not cause drug resistance and have no side effect.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine, specifically to a drug for treating joint inflammation, rheumatic bone pain, and as an adjunct treatment for acute muscle injury, and its preparation method. Background Technology

[0002] Traditional Chinese medicine (TCM) believes that osteoarthritis (referred to as "Bi syndrome" in TCM) is caused by stagnation of Qi and blood, obstruction of meridians, and invasion of soft tissues and bones by wind, cold, dampness, and other pathogenic factors. Therefore, to cure osteoarthritis, several issues must be addressed: First, stagnant Qi and blood must be activated, and blocked meridians must be cleared. Second, the pathogenic factors invading the bones must be expelled from the body. Third, normal physiological functions must be restored, the hyperplasia of degenerated joints softened, and the soft tissues of diseased bones and joints repaired. Common therapies, such as massage, traction, and electrotherapy, can promote local blood circulation and metabolism, and are suitable for the early stages of the disease. While they have some efficacy, they do not address the root cause. Oral Western medicine often only reduces inflammation and pain, but cannot target the lesions to eliminate pathogenic factors, and can cause varying degrees of side effects on the stomach, liver, and kidneys. In the later stages of the disease, surgery is often the only option, causing significant suffering for patients. Summary of the Invention

[0003] The purpose of this invention is to provide a drug for treating arthritis, rheumatic bone pain, and acute muscle injury, as well as a method for preparing the drug. This prescription uses traditional Chinese medicinal materials, which will not cause drug resistance and has no side effects.

[0004] To solve the above-mentioned technical problems, the present invention adopts the following technical solution: This invention provides a medicament for treating arthritis, rheumatic bone pain, and acute muscle injury, characterized in that it comprises the following components in parts by weight: Agarwood 5-10 parts, Liquidambar resin 1-10 parts, Panax notoginseng 1-8 parts, Clematis chinensis 1-8 parts, Cnidium monnieri 5-15 parts, Cicada slough 5-10 parts, Frankincense 10-20 parts, Menthol 10-20 parts, Dragon's blood 5-15 parts.

[0005] This invention also relates to a method for preparing the above-mentioned drug, the specific steps of which are as follows: Step 1: Take the selected weight parts of agarwood and styrax resin and mix them. Add 8-12 times the amount of water and steam distill for 8-15 hours. Collect the volatile oil and add conventional excipients to make a volatile oil inclusion complex for later use. Step 2: Take Panax notoginseng according to the selected weight proportions, add 6-10 times the amount of water to extract 1-3 times, each time for 0.5-2 hours. After discarding the water extract, collect the residue, dry it to obtain the processed Panax notoginseng product for later use. Step 3: Take the selected weight proportions of Clematis chinensis, Cnidium monnieri, Cicadae periostracum, and Boswellia carterii, mix and pulverize them with the prepared Panax notoginseng product, add the prepared volatile oil inclusion complex and conventional excipients, and prepare a clinically acceptable formulation according to conventional processes. Furthermore, in step 1, the conventional excipients for preparing the volatile oil inclusion complex include β-cyclodextrin, water, and ethanol. Furthermore, in step 1, the mass ratio of the volatile oil, β-cyclodextrin, water, and ethanol is 1:8-12:16-24:1-2. Furthermore, in step 1, the mass ratio of the volatile oil, β-cyclodextrin, water, and ethanol is 1:10:20:1. Furthermore, the frankincense is processed with vinegar. This invention can be formulated into oral preparations and topical preparations.

[0006] The beneficial effects of this invention are: the use of traditional Chinese medicinal materials in this invention will not cause drug resistance and has no side effects.

[0007] The beneficial effects of this invention will be further explained below in conjunction with the efficacy of its main components: Agarwood: [Properties and Channels Entered] It is pungent and bitter in taste, and slightly warm in nature; it enters the spleen, stomach, and kidney channels. [Functions and Indications] It promotes qi circulation and relieves pain, warms the middle jiao and stops vomiting, and regulates qi and relieves asthma; it is used for chest and abdominal distension and pain, vomiting and hiccups due to stomach cold, and shortness of breath due to kidney deficiency.

[0008] Liquidambar resin: [Properties and Channels Entered] Pungent, slightly bitter, neutral. Enters the Lung and Spleen channels. [Functions and Indications] Promotes blood circulation and relieves pain, detoxifies and promotes tissue regeneration, cools the blood and stops bleeding; used for traumatic injuries, carbuncles and boils, hematemesis, epistaxis, and external bleeding.

[0009] Panax notoginseng: [Properties and Channels Entered] Sweet and slightly bitter in taste, neutral in nature, and non-toxic. Enters the liver, stomach, and large intestine channels. [Functions and Indications] Stops bleeding, disperses blood stasis, reduces swelling, and relieves pain. Treats hematemesis, hemoptysis, epistaxis, hematochezia, bloody dysentery, metrorrhagia, abdominal masses, postpartum hemorrhage, lochia retention, traumatic bleeding, external bleeding, and carbuncles and boils with pain.

[0010] Clematis armandii: [Properties and Channels Entered] Sweet, pungent, warm. Enters the Lung and Liver channels. [Functions and Indications] Dispels wind and dampness, relaxes muscles and tendons, invigorates blood circulation and relieves pain, detoxifies and resolves rashes.

[0011] Cnidium monnieri: [Properties and Channels Entered] Pungent and bitter in taste, warm in nature. Enters the Kidney Channel. [Functions and Indications] Dries dampness and dispels wind, kills parasites and relieves itching, warms the kidneys and strengthens yang. Used for vaginal itching and leukorrhea, eczema and itching, dampness-induced arthralgia and lower back pain, kidney deficiency and impotence, and infertility due to cold uterus.

[0012] Cicada molting: [Properties and Channels Entered] Cold in nature, sweet in taste. [Functions and Indications] Disperses wind-heat, clears the lungs, and relieves spasms. Treats exogenous wind-heat, cough with hoarseness, measles with poor eruption, itchy rashes, infantile convulsions, red eyes, corneal opacity, boils and carbuncles, and tetanus.

[0013] Frankincense: [Properties and Channels Entered] Pungent, bitter, slightly warm. [Functions and Indications] Promotes blood circulation and qi flow, relieves pain, reduces swelling and promotes tissue regeneration. Indications: Abdominal pain, rheumatic pain, amenorrhea and dysmenorrhea, traumatic injuries with blood stasis, carbuncles and boils, intestinal abscesses, and slow-healing sores.

[0014] Dragon's Blood: [Properties and Channels Entered] Sweet, pungent, salty, neutral. Enters the Lung, Spleen, and Kidney channels. [Functions and Indications] Promotes blood circulation and removes blood stasis, relieves pain and stops bleeding, promotes wound healing and tissue regeneration. Used for traumatic injuries, pain due to blood stasis, stagnation of qi and blood in women, external bleeding, and slow-healing abscesses. Detailed Implementation

[0015] The technical solutions of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention.

[0016] Example 1 The medication for treating arthritis, rheumatic bone pain, and acute muscle injury consists of the following components by weight: Agarwood 6 parts, Liquidambar resin 2 parts, Panax notoginseng 5 parts, Clematis chinensis 7 parts, Cnidium monnieri 6 parts, Cicada slough 6 parts, Frankincense 15 parts, Menthol 12 parts, Dragon's blood 6 parts.

[0017] Example 2 The medication for treating arthritis, rheumatic bone pain, and acute muscle injury consists of the following components by weight: 8 parts agarwood, 8 parts styrax resin, 6 parts Panax notoginseng, 6 parts Clematis chinensis, 8 parts Cnidium monnieri, 6 parts cicada molting, 12 parts frankincense, 14 parts menthol, and 9 parts dragon's blood.

[0018] Example 3 The medication for treating arthritis, rheumatic bone pain, and acute muscle injury consists of the following components by weight: 6 parts agarwood, 2 parts styrax resin, 3 parts Panax notoginseng, 5 parts Clematis chinensis, 8 parts Cnidium monnieri, 8 parts cicada molting, 18 parts frankincense, 16 parts menthol, and 9 parts dragon's blood.

[0019] The preparation method of the medicinal wine described in Examples 1-3 above includes the following specific steps: Step 1: Mix the agarwood and styrax resin according to the weight proportions, add 8-12 times the amount of water and steam distill for 8-15 hours, collect the volatile oil, add conventional excipients to make volatile oil inclusion complex, and set aside for later use; Step 2: Take Panax notoginseng according to the weight proportions, add 6-10 times the amount of water and extract 1-3 times, each time for 0.5-2 hours. After discarding the water extract, collect the residue and dry it to obtain the processed Panax notoginseng product for later use. Step 3: Take the following ingredients by weight: Clematis armandii, Cnidium monnieri, Cicadae periostracum, and Boswellia carterii. Mix and pulverize them with the prepared Panax notoginseng product. Add the prepared volatile oil inclusion complex and conventional excipients. Prepare a clinically acceptable formulation according to conventional processes. Application examples: Case 1: Mr. Zhang, male, 42 years old, from Zhengzhou, was treated at the hospital for back and leg pain that made it difficult for him to walk. He applied topical medication four times and has now recovered.

[0020] Case 2: Li, male, 23 years old, from Zhengzhou, suffered from leg pain that made it difficult to walk. He recovered after three courses of treatment.

[0021] Case 3: Qin, female, 49 years old when she came to the clinic, from Fenghuang Town, suffered from back and leg pain that made it difficult for her to walk and work. After two courses of treatment with the medicinal liquid of this invention and oral medication, she recovered to normal.

[0022] Case 4: Xia, male, 47 years old, from Linzi. After being examined and treated at the hospital, he suffered from severe back and leg pain that made it difficult for him to walk. He received four treatments with oral medication and has now recovered.

[0023] Case 5: Li Moumou, 32 years old, from Linzi, suffered from leg pain that made it difficult to walk. After three courses of treatment, he recovered and has been engaged in the breeding industry.

[0024] Case 6: Qin, female, 49 years old when she came to the clinic, from Fenghuang Town, suffered from back and leg pain that made it difficult for her to walk and work. After treatment with this invention and two courses of treatment, she recovered to normal.

[0025] Based on modern Chinese medicine pharmacology and years of clinical trials, this invention has developed a pharmaceutical composition for treating osteoarthritis and its applications. The overall effective rate of this Chinese medicine is 100%, with a cure rate of 80-95%, and the medicinal materials do not induce drug resistance or have side effects.

[0026] Obviously, those skilled in the art can make various modifications and variations to this invention without departing from its spirit and scope. Therefore, if these modifications and variations fall within the scope of the claims of this invention and their equivalents, this invention also intends to include these modifications and variations.

Claims

1. A drug for treating arthritis, rheumatic bone pain, and acute muscle injury, characterized in that, It consists of the following components in parts by weight: Agarwood 5-10 parts, Liquidambar resin 1-10 parts, Panax notoginseng 1-8 parts, Clematis chinensis 1-8 parts, Cnidium monnieri 5-15 parts, Cicada slough 5-10 parts, Frankincense 10-20 parts, Menthol 10-20 parts, Dragon's blood 5-15 parts.

2. A method for preparing a drug for treating arthritis, rheumatic bone pain, and acute muscle injury, characterized in that, The specific steps are as follows: Step 1: Take the selected weight parts of agarwood and styrax resin and mix them. Add 8-12 times the amount of water and steam distill for 8-15 hours. Collect the volatile oil and add conventional excipients to make a volatile oil inclusion complex for later use. Step 2: Take Panax notoginseng according to the selected weight proportions, add 6-10 times the amount of water to extract 1-3 times, each time for 0.5-2 hours. After discarding the water extract, collect the residue, dry it to obtain the processed Panax notoginseng product for later use. Step 3: Take the selected weight proportions of Clematis chinensis, Cnidium monnieri, Cicadae periostracum, and Boswellia carterii, mix and pulverize them with the prepared Panax notoginseng product, add the prepared volatile oil inclusion complex and conventional excipients, and prepare a clinically acceptable formulation according to conventional processes.

3. The method for preparing the drug for treating arthritis, rheumatic bone pain, and acute muscle injury according to claim 2, characterized in that, In step 1, the conventional excipients for preparing the volatile oil inclusion complex include β-cyclodextrin, water, and ethanol.

4. The method for preparing the drug for treating arthritis, rheumatic bone pain, and acute muscle injury according to claim 3, characterized in that, In step 1, the mass ratio of the volatile oil, β-cyclodextrin, water and ethanol is 1:8-12:16-24:1-2.

5. The method for preparing the drug for treating arthritis, rheumatic bone pain, and acute muscle injury according to claim 4, characterized in that, In step 1, the mass ratio of the volatile oil, β-cyclodextrin, water, and ethanol is 1:10:20:

1.

6. The method for preparing the drug for treating arthritis, rheumatic bone pain, and acute muscle injury according to claim 5, characterized in that, The frankincense mentioned is processed with vinegar.

7. A pharmaceutical composition prepared by any one of claims 2-6.