Composition with effects of removing acnes and tightening pores and application thereof

Abstract

The invention belongs to the technical field of cosmetics, and relates to a composition with the effects of removing acnes and tightening pores and application of the composition, and the composition is prepared from Philionin, o-cymene-5-ol, bailionin, surfactin, madecassoside, jasmineshu and colloidal sulfur. According to the acne-removing composition, the paigonin, the surfactin, the madecassoside, the Jhenyeshu and the colloidal sulfur can relieve redness and swelling and stimulation caused by acne, the five components have a synergistic effect, and the paigonin, the o-cymene-5-ol and the colloidal sulfur have an antibacterial effect and can improve acne symptoms. The composition disclosed by the invention has an excellent acne removing effect and is mild and non-irritant in effect.

Description

Technical Field

[0001] This invention belongs to the field of cosmetic technology and relates to a composition with acne-removing and pore-tightening effects and its application. Background Technology

[0002] Acne, commonly known as pimples or zits, is a chronic inflammatory skin disease of the pilosebaceous unit, characterized by polymorphic lesions such as comedones, papules, pustules, and nodules, and often forms in areas with abundant sebaceous glands. With modern people placing greater emphasis on skin health, they seek acne treatment products that are safe and non-irritating while also ensuring efficacy.

[0003] There are many types of acne treatment products on the market. Products with significant effects are all somewhat irritating, and long-term use can lead to skin damage. (1) Glucocorticoid drugs for acne treatment, although they bring short-term acne treatment experience, long-term use will accumulate hormones on the skin, aggravate skin sensitivity, and the skin will develop tolerance to these drugs, leading to hormone-induced acne. It is necessary to use the drugs according to the doctor's advice, such as metronidazole and chloramphenicol, which have been banned in cosmetics. (2) Retinol has limitations in the application of cosmetic formulations, such as easy oxidation in the air and insolubility in water, which prevents retinol from fully exerting its excellent acne treatment effect. (3) Retinoic acid is also a common drug for treating acne. Its main component is all-trans retinoic acid, which is easily decomposed by light. Its side effects can cause local skin irritation reactions such as erythema, desquamation, pain, itching and stinging, and it is not suitable for sensitive skin.

[0004] The safety and efficacy of skincare products have always been a key research focus in the cosmetics industry. With the rapid increase in the number of people with sensitive skin in modern society, products that gently treat acne and have preventative effects are receiving more attention. Salicylic acid, derived from white willow, is a classic acne-fighting ingredient, and "acid-exfoliating" products often use large amounts of this ingredient to achieve good results. However, the use of high concentrations of non-plant-derived salicylic acid is not friendly to unhealthy skin, and medical acid exfoliation is expensive, with long treatment cycles and recovery periods; mild acne does not require medical acid exfoliation. Furthermore, using a single ingredient cannot improve acne caused by multiple factors, so multi-faceted acne-fighting products are more popular in the market. Summary of the Invention

[0005] In view of the shortcomings of the existing technology, the purpose of this invention is to provide a composition with acne-removing and pore-tightening effects and its application.

[0006] To achieve this objective, the present invention adopts the following technical solution:

[0007] In a first aspect, the present invention provides a composition having the effects of acne removal and pore tightening, the composition comprising Piocinone, o-cymene-5-ol, Belinone, Aotingmin, hydroxyascorbic acid, Xinminshu and colloidal sulfur.

[0008] Piocin is a safe and long-term usable novel high-efficiency bactericide that can exert antibacterial effects against bacteria and various fungi at low concentrations. It is particularly effective against Propionibacterium acnes, the cause of acne, and can significantly improve the symptoms of acne and multiple acne breakouts.

[0009] o-Cymenyl-5-ol is an isomer of thymol and has a clear bactericidal effect against Staphylococcus aureus.

[0010] Belinin can inhibit capsaicin receptor (TRPV1) and nerve action potential (AP), reducing skin irritation. At the same time, it can inhibit the expression of inflammatory factors (such as TNF-α and IL-1α) and inflammatory mediators (such as COX-2), reducing skin redness, swelling and pain, and repairing the skin barrier function.

[0011] Aotingmin is made from multi-strain lactobacillus fermentation technology, which provides comprehensive care for the skin by regulating the balance of gut flora and improving inflammation.

[0012] Hydroxyasiaticoside has a wide range of biological activities, including anti-inflammatory, wound healing, acne scar fading, and antioxidant activities.

[0013] Colloidal sulfur can effectively inhibit Gram-positive bacteria and some fungi, and has the effects of controlling oil, promoting skin metabolism, regulating the differentiation of keratinocytes, and relieving inflammation and irritation caused by rosacea.

[0014] Xinminshu can inhibit the release of inflammatory mediators, thereby relieving redness, rash, and erythema caused by vasodilation, vasoconstriction, and new blood vessel formation.

[0015] Piocin, o-cymene-5-ol, and colloidal sulfur can inhibit Propionibacterium acnes, bacteria, and various fungi that cause acne, and can effectively improve the symptoms of acne and multiple acne. Piocin and o-cymene-5-ol have a certain synergistic effect in the above-mentioned effects. Betaine, Aotin, asiaticoside, Xinminshu, and colloidal sulfur can relieve redness and irritation caused by acne, and there is a synergistic effect among the five ingredients.

[0016] Preferably, the composition comprises, by weight parts, 0.1-10 parts of piodin, 0.01-0.1 parts of o-cymene-5-ol, 0.1-10 parts of betaine, 0.1-5 parts of anomin, 0.01-1 parts of hydroxyascorbic acid, 0.001-1 parts of xinminshu, and 0.1-13 parts of colloidal sulfur.

[0017] The mass fractions of piocin can be selected from 0.1 parts, 0.5 parts, 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, etc.; the mass fractions of o-cymene-5-ol can be selected from 0.01 parts, 0.02 parts, 0.03 parts, 0.04 parts, 0.05 parts, 0.06 parts, 0.07 parts, 0.08 parts, 0.09 parts, 0.1 parts, etc.; the mass fractions of betaine can be selected from 0.1 parts, 0.5 parts, 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, etc.; the mass fractions of anomin can be selected from 0.1 parts, 0.5 parts, 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts, etc.; the mass fractions of hydroxyascorbic acid glycoside ... Choose from 0.01 parts, 0.02 parts, 0.05 parts, 0.08 parts, 0.1 parts, 0.2 parts, 0.3 parts, 0.4 parts, 0.5 parts, 0.6 parts, 0.7 parts, 0.8 parts, 0.9 parts, 1 part, etc. For Xinminshu, choose from 0.001 parts, 0.005 parts, 0.01 parts, 0.05 parts, 0.1 parts, 0.2 parts, 0.3 parts, 0.4 parts, 0.5 parts, 0.6 parts, 0.7 parts, 0.8 parts, 0.9 parts, 1 part, etc. For colloidal sulfur, choose from 0.1 parts, 0.5 parts, 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts, etc. Other specific values ​​within the above ranges can be selected, and will not be elaborated further here.

[0018] Preferably, the composition further includes Laricyl LS 8865 and nicotinamide.

[0019] Laricyl LS 8865 is an extract of medicinal mushrooms grown in Eastern Europe, which has the effects of minimizing pores, firming the skin, and moisturizing.

[0020] Niacinamide has the effects of whitening skin, preventing yellowing of skin, controlling oil and shrinking pores.

[0021] When used together, the two have a synergistic effect in shrinking pores.

[0022] Preferably, the composition further comprises, by weight, 0.1-10 parts of Laricyl LS 8865 and 0.1-3 parts of nicotinamide.

[0023] The mass fractions of Laricyl LS 8865 can be selected from 0.1, 0.2, 0.5, 0.8, 1, 2, 3, 4, 5, 6, 7, 8, 9, and 10 parts, while the mass fractions of nicotinamide can be selected from 0.1, 0.2, 0.5, 0.8, 1, 1.5, 2, 2.5, and 3 parts. Other specific values ​​within the above ranges can also be selected, which will not be elaborated here.

[0024] Secondly, the present invention provides the application of the composition according to the first aspect, which has the effects of acne removal and pore tightening, in the preparation of cosmetics.

[0025] Preferably, the cosmetic includes serum, lotion, and cream.

[0026] Thirdly, the present invention provides an essence with acne-removing and pore-tightening effects, the essence comprising the composition with acne-removing and pore-tightening effects described in the first aspect, a moisturizer, a thickener, a preservative, and water.

[0027] Preferably, the essence comprises, by weight, 0.7-60 parts of the composition with acne-removing and pore-tightening effects described in the first aspect, 1-16 parts of moisturizer, 0.1-9 parts of thickener, 0.3-4 parts of preservative, and 65-85 parts of water.

[0028] The composition with acne-reducing and pore-tightening effects can be selected in parts by weight of 0.7, 1, 2, 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, and 60, etc.; the moisturizer can be selected in parts by weight of 1, 2, 4, 6, 8, 10, 12, 14, and 16, etc.; and the thickener can be selected in parts by weight of 0.1, 0.2, 0.5, and 0.8. The quantities of water can be selected as follows: 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, etc. The quantities of preservative can be selected as 0.3 parts, 0.5 parts, 0.8 parts, 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, etc. The quantities of water can be selected as 65 parts, 68 parts, 70 parts, 72 parts, 75 parts, 78 parts, 80 parts, 82 parts, 85 parts, etc. Other specific values ​​within the above range can be selected, which will not be elaborated here.

[0029] Preferably, the moisturizer includes any one or a combination of at least two of butylene glycol, sodium hyaluronate, allantoin, or glycerin.

[0030] Preferably, the thickener comprises any one or a combination of at least two of ammonium acryloyl dimethyl taurate / behenol polyether-25 methacrylate crosspolymer, xanthan gum, or AT 100P.

[0031] Preferably, the preservative includes any one or a combination of at least two of 1,2-hexanediol, p-hydroxyacetophenone, or 1,2-pentanediol.

[0032] Fourthly, the present invention provides a method for preparing an essence with acne-removing and pore-tightening effects according to the third aspect, the preparation method comprising:

[0033] (1) Mix water, humectant, and thickener to obtain a first mixture;

[0034] (2) The first mixture is mixed with a preservative and a composition that has the effects of removing acne and tightening pores to obtain the final product.

[0035] Preferably, the mixing temperature in step (1) is 80-90℃, such as 80℃, 82℃, 84℃, 86℃, 88℃, 90℃, etc. Other specific values ​​within the above range can be selected, and will not be described in detail here.

[0036] Preferably, the mixing temperature in step (2) is 10-45℃, such as 10℃, 15℃, 20℃, 25℃, 30℃, 35℃, 40℃, 45℃, etc. Other specific values ​​within the above range can be selected, and will not be described in detail here.

[0037] Compared with the prior art, the present invention has the following beneficial effects:

[0038] The five ingredients—Belining, Aotingmin, Hydroxyacarboxylic Acid, Xinminshu, and Colloidal Sulfur—can alleviate inflammation and irritation caused by acne, and there is a synergistic effect among them. Piocin, o-cymene-5-ol, and Colloidal Sulfur have antibacterial effects and can improve acne symptoms. This invention's composition, while possessing excellent acne-removing efficacy, is gentle and non-irritating. Detailed Implementation

[0039] The technical solution of the present invention will be further illustrated below through specific embodiments. Those skilled in the art should understand that the embodiments described are merely illustrative of the present invention and should not be construed as limiting the invention in any way.

[0040]

[0041] Example 1

[0042] This embodiment provides a composition with acne-removing and pore-tightening effects. The composition comprises, by weight parts, 5 parts of Piaolin, 0.05 parts of o-cymene-5-ol, 5 parts of Belinin, 3 parts of Aotingmin, 0.5 parts of hydroxyascorbic acid, 0.5 parts of Xinminshu, and 6 parts of colloidal sulfur.

[0043] The preparation method is as follows: the raw materials are physically mixed to obtain the product.

[0044] Example 2

[0045] This embodiment provides a composition with acne-removing and pore-tightening effects. The composition includes, by weight parts, 2 parts of Piaolin, 0.1 parts of o-cymene-5-ol, 10 parts of Belinin, 0.1 parts of Aotingmin, 0.01 parts of hydroxyascorbic acid, 1 part of Xinminshu, and 3 parts of colloidal sulfur.

[0046] The preparation method is the same as in Example 1.

[0047] Example 3

[0048] This embodiment provides a composition with acne-removing and pore-tightening effects. The composition comprises, by weight parts, 10 parts of Piaolin, 0.01 parts of o-cymene-5-ol, 0.1 parts of Belinin, 5 parts of Aotingmin, 1 part of hydroxyascorbic acid, 0.01 parts of Xinminshu, and 13 parts of colloidal sulfur.

[0049] The preparation method is the same as in Example 1.

[0050] Example 4

[0051] This embodiment provides a composition with acne-removing and pore-tightening effects. The composition comprises, by weight parts, 5 parts of Piocin, 0.05 parts of o-cymene-5-ol, 5 parts of Belinin, 3 parts of Aotingmin, 0.5 parts of hydroxyascorbic acid, 0.5 parts of Xinminshu, 6 parts of colloidal sulfur, 2 parts of Laricyl LS 8865, and 1 part of niacinamide.

[0052] The preparation method is the same as in Example 1.

[0053] Example 5

[0054] This embodiment provides a composition with acne-removing and pore-tightening effects. The composition comprises, by weight parts, 5 parts of Piocin, 0.05 parts of o-cymene-5-ol, 5 parts of Belinin, 3 parts of Aotinmin, 0.5 parts of hydroxyascorbic acid, 0.5 parts of Xinminshu, 6 parts of colloidal sulfur, 0.1 parts of Laricyl LS 8865, and 3 parts of niacinamide.

[0055] The preparation method is the same as in Example 1.

[0056] Example 6

[0057] This embodiment provides a composition with acne-removing and pore-tightening effects. The composition comprises, by weight parts, 5 parts of Piazoline, 0.05 parts of o-cymene-5-ol, 5 parts of Belinine, 3 parts of Aotinmin, 0.5 parts of hydroxyascorbic acid, 0.5 parts of Xinminshu, 6 parts of colloidal sulfur, 10 parts of Laricyl LS 8865, and 0.1 parts of niacinamide.

[0058] The preparation method is the same as in Example 1.

[0059] Example 7

[0060] This embodiment provides a composition with acne-removing and pore-tightening effects. The only difference between this composition and Example 4 is that it does not contain Laricyl LS 8865, and the reduced mass of Laricyl is allocated to the mass of niacinamide. The other ingredients and contents remain unchanged.

[0061] The preparation method is the same as in Example 1.

[0062] Example 8

[0063] This embodiment provides a composition with acne-removing and pore-tightening effects. The only difference between this composition and Example 4 is that it does not contain niacinamide, and the reduced mass of niacinamide is allocated to the mass of Laricyl LS 8865. The other ingredients and contents remain unchanged.

[0064] The preparation method is the same as in Example 1.

[0065] Comparative Example 1

[0066] This comparative example provides a composition with acne-removing and pore-tightening effects. The only difference between this composition and Example 1 is that it does not contain piracetam and the mass fraction of o-cymene-5-ol is adjusted to 0.1 parts, while the other components and contents remain unchanged.

[0067] The preparation method is the same as in Example 1.

[0068] Comparative Example 2

[0069] This comparative example provides a composition with acne-removing and pore-tightening effects. The only difference between this composition and Example 1 is that it does not contain o-cymene-5-ol, and the reduced mass of o-cymene-5-ol is allocated to the mass of piracetam. The other components and contents remain unchanged.

[0070] The preparation method is the same as in Example 1.

[0071] Comparative Example 3

[0072] This comparative example provides a composition with acne-removing and pore-tightening effects. The only difference between this composition and Example 1 is that it does not contain Belinin, and the reduced mass of Belinin is proportionally allocated to the mass of Aotinmin, Hydroxyasiaticoside, Xinminshu and Colloidal Sulfur, while the other components and contents remain unchanged.

[0073] The preparation method is the same as in Example 1.

[0074] Comparative Example 4

[0075] This comparative example provides a composition with acne-removing and pore-tightening effects. The only difference between this composition and Example 1 is that it does not contain acetaminophen, and the reduced mass of acetaminophen is proportionally allocated to the mass of acetaminophen, hydroxyascorbic acid, acetaminophen and colloidal sulfur, while the other components and contents remain unchanged.

[0076] The preparation method is the same as in Example 1.

[0077] Comparative Example 5

[0078] This comparative example provides a composition with acne-removing and pore-tightening effects. The only difference between this composition and Example 1 is that it does not contain asiaticoside, and the reduced mass of asiaticoside is proportionally allocated to the mass of Belinin, Aotingmin, Xinminshu and colloidal sulfur, while the other components and contents remain unchanged.

[0079] The preparation method is the same as in Example 1.

[0080] Comparative Example 6

[0081] This comparative example provides a composition with acne-removing and pore-tightening effects. The only difference between this composition and Example 1 is that it does not contain Xinminshu, and its reduced mass is proportionally allocated to the mass of Beilining, Aotingmin, hydroxyascorbic acid and colloidal sulfur, while the other components and contents remain unchanged.

[0082] The preparation method is the same as in Example 1.

[0083] Comparative Example 7

[0084] This comparative example provides a composition with acne-removing and pore-tightening effects. The only difference between this composition and Example 1 is that it does not contain colloidal sulfur. The reduced mass of this sulfur is proportionally allocated to the mass of Belinin, Aotingmin, hydroxyascorbic acid, and Xinminshu, while the other components and contents remain unchanged.

[0085] The preparation method is the same as in Example 1.

[0086] Application Example 1

[0087] This application example provides a serum with acne-reducing and pore-tightening effects. The serum's formula is as follows:

[0088]

[0089] Its preparation method is as follows:

[0090] (1) Mix water, humectant, ammonium acryloyl dimethyl taurate / behenol polyether-25 methacrylate crosspolymer, and xanthan gum, and heat to 85°C while stirring until homogeneous;

[0091] (2) Cool the mixture obtained in step (1) to 60°C, add AT 100P and stir to dissolve evenly.

[0092] (3) Cool the mixture obtained in step (2) to 45°C and mix it with the preservative and the composition to obtain the final product.

[0093] Application Example 2

[0094] This application example provides a serum with acne-reducing and pore-tightening effects. The serum's formula is as follows:

[0095]

[0096] Its preparation method is as follows:

[0097] (1) Mix water, humectant, ammonium acryloyl dimethyl taurate / behenol polyether-25 methacrylate crosspolymer, and xanthan gum, and heat to 80°C while stirring until homogeneous;

[0098] (2) Cool the mixture obtained in step (1) to 60°C, add AT 100P and stir to dissolve evenly.

[0099] (3) Cool the mixture obtained in step (2) to 30°C and mix it with the preservative and the composition to obtain the final product.

[0100] Application Example 3

[0101] This application example provides a serum with acne-reducing and pore-tightening effects. The serum's formula is as follows:

[0102]

[0103] Its preparation method is as follows:

[0104] (1) Mix water, humectant, ammonium acryloyl dimethyl taurate / behenol polyether-25 methacrylate crosspolymer, and xanthan gum, and heat to 90°C while stirring until homogeneous;

[0105] (2) Cool the mixture obtained in step (1) to 60°C, add AT 100P and stir to dissolve evenly.

[0106] (3) Cool the mixture obtained in step (2) to 10°C and mix it with the preservative and the composition to obtain the final product.

[0107] Application Example 4 - 8

[0108] This application example provides 5 kinds of essence liquids with the effects of removing acne and tightening pores. The difference from Application Example 1 is only that the composition of Example 1 is replaced equally with the compositions described in Examples 4 - 8, and other ingredients and their contents remain unchanged.

[0109] The preparation method refers to Application Example 1.

[0110] Comparative Application Example 1 - 7

[0111] This application example provides 7 kinds of essence liquids with the effects of removing acne and tightening pores. The difference from Application Example 1 is only that the composition of Example 1 is replaced equally with the compositions described in Comparative Examples 1 - 7, and other ingredients and their contents remain unchanged.

[0112] The preparation method refers to Application Example 1.

[0113] Test Example 1

[0114] Antibacterial effect test: Referring to the "Disinfection Technical Specification" (2002 edition), a 24 - hour antibacterial test was carried out on the acne - removing essence liquids of Application Examples 1 - 8 and Comparative Application Examples 1 - 7 to test the inhibitory effect on bacteria. The results are shown in Tables 1 and 2.

[0115] Irritation test: The red blood cell hemolysis experiment (RBC) is one of the alternative methods for the rabbit eye irritation test. The basic principle is to evaluate the damage of chemicals to eye tissue cells by measuring the amount of hemoglobin released from cells and the degree of denaturation. The RBC experiment can be used to evaluate the eye irritation of cosmetics. Therefore, in order to evaluate the sensitivity of the acne - removing essence liquids of Application Examples 1 - 8 and Comparative Application Examples 1 - 7, the red blood cell hemolysis experiment was also carried out on the acne - removing essence liquids of Application Examples 1 - 8 and Comparative Application Examples 1 - 7. The results are shown in Table 3; this experiment uses the RBC experiment test method and judgment criteria of the European Alternative Method Validation Center. The specific judgment criteria are as follows: L / D > 100 indicates no irritation, 10 < L / D ≤ 100 indicates slight irritation, 1 < L / D ≤ 10 indicates mild irritation, 0.1 < L / D ≤ 1 indicates moderate irritation, and L / D ≤ 0.1 indicates severe irritation; where HD50 is the sample concentration when 50% of red blood cells undergo hemolysis, DI is the protein denaturation index, and L / D is the ratio of HD50 to DI.

[0116] Acne - removing effect test: 15 groups of acne - prone skin subjects were recruited, with 5 people in each group, aged between 20 - 30 years old and having acne of different degrees. The test areas were determined, and equal amounts of the acne - removing essence liquids of each application example and comparative application example were used for 7 days. During the use of the products, the Antera3D device was used to collect the changes in the volume, surface area, and skin red value of the acne of the volunteers after 3 days and 7 days of use, and the average test data was recorded in Tables 4 - 5.

[0117] Oil control effect test: Active pore count (NAP) and skin surface sebum percentage (SSP) tests were conducted on 75 volunteers aged 18-40, regardless of gender. The selection criteria were: sebum level ≥150μg / cm³ three hours after morning cleansing. 2 Users were randomly divided into 15 groups. After cleansing their faces, each group applied a pea-sized sample of the compositions provided in Examples 1-8 and the compositions provided in Comparative Examples 1-7 to their foreheads, gently patting until absorbed. The treatment was performed twice daily, morning and evening. Using an active skin surface analysis system, the number of active pores (NAP) and the percentage of surface sebum (SSP) were tested after week 4 and 7 days of discontinuation. The average value of the users' test results was taken, with the number of active pores (NAP) and the percentage of surface sebum (SSP) in the test area 30 minutes after cleansing as the initial values. The test results are shown in Table 6.

[0118] The inhibition rates of Escherichia coli, Staphylococcus aureus, and Propionibacterium acnes are shown in Table 1, and the inhibition rate of Candida albicans is shown in Table 2.

[0119] Table 1

[0120]

[0121] Table 2

[0122]

[0123] As shown in Table 1-2, the acne-removing essences obtained in Application Examples 1-8 all exhibited high inhibition rates against Escherichia coli, Propionibacterium acnes, Staphylococcus aureus, and Candida albicans. In contrast, the antibacterial rates of Comparative Application Examples 1-2 and Comparative Application Example 7 were significantly reduced. This indicates that there is a synergistic effect between the piodin and o-cymene-5-ol components in the composition with acne-removing and pore-tightening effects, resulting in a synergistic effect in antibacterial activity. Furthermore, the addition of colloidal sulfur can further enhance the antibacterial effect.

[0124] The L / D ratio and irritation grading results are shown in Table 3.

[0125] Table 3

[0126]

[0127] As shown in Table 3, the acne-removing serums obtained in Examples 1-8 were classified as non-irritating, while the acne-removing serums prepared in Examples 3-7 were classified as slightly irritating. This indicates that combining Pyrine, Aotin, hydroxyascorbic acid, Xinminshu, and colloidal sulfur can produce a significant synergistic effect in soothing and repairing, and can effectively alleviate skin sensitivity and external irritation caused by Pyrine and o-cymene-5-ol.

[0128] The acne-removing effect test results after 3 days of product use are shown in Table 4, and the acne-removing effect test results after 7 days of product use are shown in Table 5.

[0129] Table 4

[0130]

[0131] Table 5

[0132]

[0133] Analysis of the data in Tables 4 and 5 shows that the acne-reducing essences in Examples 1-8 exhibit significant effects in reducing acne and redness, with significantly higher reduction rates in total acne volume, total acne surface area, and skin redness compared to comparative Examples 1-7. Notably, the compositions in Comparative Examples 1-7, which possess acne-reducing and pore-tightening effects, lack one of the following: Pianonin, o-cymene-5-ol, Belinin, Aotinmin, asiaticoside, Xinminshu, or colloidal sulfur. Consequently, their effects are significantly lower than those in the examples. This demonstrates that the seven substances—Pianonin, o-cymene-5-ol, Belinin, Aotinmin, asiaticoside, Xinminshu, and colloidal sulfur—are essential in the acne-reducing and pore-tightening compositions of this application. Furthermore, Pianonin and o-cymene-5-ol, as well as Belinin, Aotinmin, asiaticoside, Xinminshu, and colloidal sulfur, exhibit certain synergistic effects in achieving the aforementioned effects. Table 4 shows the test data for 3 days, and Table 5 shows the test data for 7 days. The effect after 7 days of use is significantly improved compared to 3 days, while the difference in the comparative application examples is not significant. Therefore, in summary, it can be seen that the composition of this application, which has the effects of acne removal and pore tightening, contains Piocinone, o-cymene-5-ol, Belinone, Aotingmin, hydroxyascorbic acid, Xinminshu, and colloidal sulfur, which can synergistically enhance the effect, not only resulting in faster overall acne removal and redness reduction, but also reducing the likelihood of consumers being intolerant to acne and redness removal products.

[0134] The rate of change of the results of the active pore count (NAP) and skin surface sebum percentage (SSP) tests from the initial values ​​is shown in Table 6.

[0135] Table 6

[0136]

[0137] As shown in Table 6, all application examples and control examples reduced the number of active pores and the percentage of sebum on the skin surface. Relatively speaking, the compositions provided in application examples 4-6 were more effective in reducing the number of active pores and the percentage of sebum on the skin surface, and maintained a good effect of inhibiting sebum secretion and shrinking pores for a certain period of time after discontinuation of the drug. Application examples 7-8 lacked either Laricyl LS 8865 or nicotinamide, and their effects were significantly lower than those in application examples 4-6. Control example 7 lacked colloidal sulfur, and its effect was greatly reduced. This shows that Laricyl LS 8865 and nicotinamide work synergistically to effectively inhibit sebum secretion and shrink pores, and can maintain this effect for a certain period of time. The addition of colloidal sulfur can further enhance the above effects.

[0138] In summary, the various components of the composition of the present invention, which has the effects of removing acne and tightening pores, work synergistically to achieve the effects of removing acne and redness. Long-term use can shrink pores and reduce the sebum content of the skin.

[0139] The above description is only a specific embodiment of the present invention, but the protection scope of the present invention is not limited thereto. Those skilled in the art should understand that any changes or substitutions that can be easily conceived by those skilled in the art within the technical scope disclosed in the present invention fall within the protection and disclosure scope of the present invention.

Claims

1. A composition having the effects of acne removal and pore tightening, characterized in that, The composition includes piodin, o-cymene-5-ol, betaine, anomin, hydroxyascorbic acid, senna, and colloidal sulfur.

2. The composition with acne-removing and pore-tightening effects according to claim 1, characterized in that, The composition comprises, by weight parts, 0.1-10 parts of piodin, 0.01-0.1 parts of o-cymene-5-ol, 0.1-10 parts of betaine, 0.1-5 parts of anomin, 0.01-1 parts of asiaticoside, 0.001-1 parts of xinminshu, and 0.1-13 parts of colloidal sulfur.

3. The composition with acne-removing and pore-tightening effects according to claim 1 or 2, characterized in that, The composition also includes Laricyl LS 8865 and nicotinamide; Preferably, the composition further comprises, by weight, 0.1-10 parts of Laricyl LS 8865 and 0.1-3 parts of nicotinamide.

4. The use of the composition with acne-removing and pore-tightening effects according to any one of claims 1-3 in the preparation of cosmetics.

5. The application according to claim 4, characterized in that, The cosmetics include serums, lotions, and creams.

6. A serum with acne-removing and pore-tightening effects, characterized in that, The essence comprises the composition with acne-removing and pore-tightening effects as described in any one of claims 1-3, a moisturizer, a thickener, a preservative, and water.

7. The essence with acne-removing and pore-tightening effects according to claim 6, characterized in that, The essence comprises, by weight, 0.7-60 parts of the composition with acne-removing and pore-tightening effects as described in any one of claims 1-3, 1-16 parts of moisturizer, 0.1-9 parts of thickener, 0.3-4 parts of preservative, and 65-85 parts of water.

8. The serum with acne-removing and pore-tightening effects according to claim 6 or 7, characterized in that, The moisturizer includes any one or a combination of at least two of butylene glycol, sodium hyaluronate, allantoin, or glycerin. Preferably, the thickener comprises any one or a combination of at least two of ammonium acryloyl dimethyl taurate / behenol polyether-25 methacrylate crosspolymer, xanthan gum, or AT 100P; Preferably, the preservative includes any one or a combination of at least two of 1,2-hexanediol, p-hydroxyacetophenone, or 1,2-pentanediol.

9. A method for preparing an essence with acne-removing and pore-tightening effects according to any one of claims 6-8, characterized in that, The preparation method includes: (1) Mix water, humectant, and thickener to obtain a first mixture; (2) The first mixture is mixed with a preservative and a composition that has the effects of removing acne and tightening pores to obtain the final product.

10. The preparation method according to claim 9, characterized in that, The mixing temperature in step (1) is 80-90℃; Preferably, the mixing temperature in step (2) is 10-45°C.

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