Implant with honeycomb micro-nano topological structure on surface as well as preparation method and application of implant

By preparing a honeycomb-like micro/nano topological structure on the surface of a titanium-based implant and then subjecting it to hydrogenation treatment, the limitations of antibacterial coatings on the implant surface were overcome, achieving a non-invasive therapeutic effect that rapidly eliminates bacterial infection and promotes osseointegration.

CN121944237APending Publication Date: 2026-05-01THE UNIVERSITY OF HONG KONG SHENZHEN HOSPITAL
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Patent Information

Application Number
CN202411541028.6
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-10-31
Publication Date
2026-05-01

AI Technical Summary

Technical Problem

Existing antibacterial coatings on implant surfaces have problems such as limited capacity to carry antibacterial substances, difficulty in controlling antibacterial effects, and the risk of bacterial infection recurrence due to coating failure. Furthermore, traditional methods may have potential toxicity to normal cells.

Method used

A honeycomb-like micro/nano topological structure layer was prepared on the surface of a titanium-based implant using a template method, and then hydrogenated using a radio frequency plasma system to form a hydrogenated titanium dioxide surface with near-infrared light response. Near-infrared photocatalysis was used to generate reactive oxygen species to eliminate bacterial infection and regulate macrophage polarization.

Benefits of technology

It achieves rapid elimination of bacterial infection without secondary surgery, promotes bone integration, reduces inflammatory response, and provides a non-invasive and efficient implant surface modification strategy with the ability to eliminate bacterial infection and regulate bone integration through near-infrared light response.

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Abstract

The invention discloses an implant with a honeycomb-shaped micro-nano topological structure on the surface and a preparation method and application thereof, and the implant with the honeycomb-shaped micro-nano topological structure on the surface is a honeycomb-shaped micro-nano topological structure layer prepared on the surface of a titanium substrate through a template method. According to the invention, a unique hydrogenated titanium dioxide honeycomb-shaped surface micro-nano topological structure is designed on the surface of the titanium-based implant through a template method and plasma hydrotreating on the basis of not introducing an antibacterial substance coating and complex chemical components; the special surface treatment not only has excellent 800-815nm near-infrared light response photocatalytic performance and can generate a large number of reactive oxygen species to quickly eliminate bacterial infection, but also can regulate polarization of macrophages due to the unique surface morphology, effectively inhibit inflammatory response and regulate and control bone immune microenvironment to promote osteogenesis, and has a good application prospect. And therefore, more than two invasive operations are not required to be carried out on the patient, and the postoperative healing effect is better.
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