Bactericidal composition containing benziothiazolinone and Inpyrfluxam

Abstract

The invention provides a bactericidal active component composition containing benziothiazolinone and Inpyrfluxam, wherein the weight ratio of the benziothiazolinone to the Inpyrfluxam in the bactericidal active component composition is (1: 120) to (120: 1). The bactericidal composition disclosed by the invention has a synergistic effect on prevention and treatment of agricultural diseases within a limited ratio range. The invention also relates to a bactericide containing the bactericidal active ingredient composition, and a method and application of the bactericidal active ingredient composition or the bactericide for preventing and treating agricultural diseases.

Description

Technical Field

[0001] This invention belongs to the agricultural field, specifically relating to a bactericidal composition containing thiamethoxam and Inpyrfluxam and its application. Background Technology

[0002] Thiamethoxam (also known as 1,2-benzisothiazolin-3-one), belonging to the isothiazole heterocyclic compound class, is a novel, highly effective, low-toxicity, broad-spectrum fungicide. Its mechanism of action primarily involves binding to anions or sulfhydryl groups on the surface of pathogen cell membranes, disrupting the pathogen's nuclear structure, damaging protein and cell membrane synthesis systems, interfering with pathogen cell metabolism, inhibiting pathogen reproduction, and ultimately leading to pathogen death. This compound exhibits good control effects against bacterial and fungal diseases affecting crops.

[0003] Inpyrfluxam is a succinate dehydrogenase inhibitor (SDHI) fungicide. It works by interfering with complex II in the mitochondrial respiratory electron transport chain of pathogens, inhibiting mitochondrial function, preventing energy production, suppressing pathogen growth, and ultimately leading to pathogen death. It can be applied to wheat, corn, rice, sorghum, peanuts, potatoes, soybeans, rapeseed, sugar beets, fruit trees, and vegetables to control various diseases such as rice sheath blight, grape powdery mildew, wheat leaf blight, barley net blight, and wheat scab.

[0004] CN109452287A discloses a bactericidal composition containing Dichlobentiazox and Inpyrfluxam, used to control various diseases such as rice sheath blight, rice blast, grape powdery mildew, apple scab, and cucumber anthracnose.

[0005] CN116209355A discloses a fungicidal composition comprising chlorfluazuril, Inpyrfluxam, and a third active compound. It is used to control fungal diseases such as wheat leaf blight and barley net blotch.

[0006] Rice sheath blight is one of the most widespread and damaging diseases of rice, mainly caused by Rhizoctonia solani. The pathogen overwinters primarily as sclerotia in the soil, then floats on the water surface the following year to infect rice plants. The disease mainly occurs on leaf sheaths and leaves, initially appearing as small, water-soaked, dark green spots, which later expand into large oval or cloud-like spots with brown edges and a grayish-green center. Under high humidity, white, spiderweb-like mycelium can be seen on the diseased parts, later forming brown, easily detached sclerotia. The disease develops rapidly under high temperature and humidity conditions, especially after rice canopies have closed, when the field is shaded and humid. Fields with excessive nitrogen fertilizer application and overly dense planting tend to be more severely affected.

[0007] Fusarium head blight is a devastating ear disease that not only reduces yield but also poses a significant threat to human and animal health due to the toxins produced by the pathogen. Initially, water-soaked brown spots appear on the glumes, later expanding and causing partial or complete yellowing of the spikelets. In humid conditions, a pink or orange-yellow mold layer develops on the affected areas, and small black granules may appear in later stages. Infected grains become shriveled and lose their luster. The pathogen overwinters on crop residues such as corn stalks and rice stubble, and the disease's spread is closely related to weather conditions during the flowering period.

[0008] Currently, there are no reports of existing technologies involving the combination of thiamethoxam and Inpyrfluxam. Summary of the Invention

[0009] The purpose of this invention is to screen effective compound agents for common but difficult-to-control diseases in agricultural production, such as rice sheath blight and wheat scab, using existing technologies. Through research, the inventors discovered that the combination of thiamethoxam and Inpyrfluxam has a significant synergistic effect, effectively controlling a variety of agricultural diseases, including the aforementioned two diseases. Based on this, this invention was completed.

[0010] One aspect of this invention relates to a bactericidal active ingredient composition, wherein the bactericidal active ingredient composition contains two active ingredients: thiamethoxam and Inpyrfluxam.

[0011] In the bactericidal active ingredient composition of the present invention, the weight ratio of thiamethoxam to Inpyrfluxam is 1:120 to 120:1, preferably 1:60 to 60:1, and more preferably 1:30 to 30:1. Examples include: 30:1, 29:1, 28:1, 27:1, 26:1, 25:1, 24:1, 23:1, 22:1, 21:1, 20:1, 19:1, 18:1, 17:1, 16:1, 15:1, 14:1, 13:1, 12:1, 11:1, 10:1, 9:1, 8:1, 7:1, 6:1, 5:1, 4:1, 3:1, 2:1. 1:1, 1:2, 1:3, 1:4, 1:5, 1:6, 1:7, 1:8, 1:9, 1:10, 1:11, 1:12, 1:13, 1:14, 1:15, 1:16, 1:17, 1:18, 1:19, 1:20, 1:21, 1:22, 1:23, 1:24, 1:25, 1:26, 1:27, 1:28, 1:29, 1:30.

[0012] In a preferred embodiment of the present invention, the weight ratio of thiamethoxam to Inpyrfluxam is further preferably 1:15 to 15:1, even more preferably 7.5:1 to 1:1, for example 7.5:1, 7:1, 6.5:1, 6:1, 5.5:1, 5:1, 4.5:1, 4:1, 3.5:1, 3:1, 2.5:1, 2:1, 1.5:1, 1:1.

[0013] In addition to the two active ingredients, thiamethoxam and Inpyrfluxam, the bactericidal active ingredient composition of the present invention may also contain other known bactericides, such as: Triazoles: Tebuconazole, Hexaconazole, Propiconazole, Prothioconazole, Triadimefon, Bisbenzyltriazole, Cycloconazole, Tebuconazole, Zimbabenazole, Oxytetracycline, Cyproconazole, Flusilazole, Tebuconazole, Cycloconazole, Paclobutrazol, Tebuconazole, Silozoline, Flufenoxuron; Methoxyacrylates: azoxystrobin, pyraclostrobin, oxadiazon, pyraclostrobin, difenoconazole, cyproconazole, pyraclostrobin; Carboxamides; Benzoyl sulfadiazine, Benzoyl sulfadiazine, Mefenoxam, Cyclopyralid, Cyclopyralid, Fluopyram, Furazolidone, Isothiazamide, Propyrazosulfuron, Metalaxyl, Metalaxyl-M, Mefenoxam, Bromofluopyram, Fluopyram, Thiamethoxam; Carboxymorpholines: dimethomorpholine, flumethomorpholine; Benzimidazoles: Carbendazim, Benomyl, Thiamethoxam, Mefenoxam, Thiamethoxam; Dicarboxyimide derivatives: iprodione, procymidone, vinclozolin; Amides: thiamethoxam, flumorpholine, dimethomorpholine, silthiamethoxam, chlorpyrifos; Pyrroles: Seed dressing pyrrole, fludioxonil; Pyrimidine derivatives: pyrimethanil, fluazolidinium, sulfadiazine, cyprodinil, fluazolidinium, isopyram, pyrimethanil, pyrimethanil, chlorpyrifos, chlorpyrifos, dimethoprim; Carbamates: Mancozeb, Mancozeb, Mancozeb, Mancozeb, Mancozeb, Zinc thiram, Mancozeb, Zinc thiram; Organochlorine compounds: chlorothalonil, bacteriostatic agent, dichlorophenol, sulfadiazine, hexachlorobenzene, pendimethalin, pentachlorophenol and its salts, tetrachlorophthalide, pentachloronitrobenzene, methyl thiophanate.

[0014] In a preferred embodiment of the present invention, the bactericidal active ingredient composition consists of only two active ingredients: thiamethoxam and Inpyrfluxam.

[0015] In this invention, the combination of thiamethoxam and Inpyrfluxam, two active ingredients, exhibits a significant synergistic effect in the control of agricultural diseases. This synergistic effect is particularly pronounced in the control of wheat scab and rice sheath blight, making it the preferred formulation of this invention.

[0016] Another aspect of the present invention relates to a fungicide, wherein the fungicide comprises the fungicide active ingredient composition described in the present invention, and agriculturally acceptable adjuvants and / or carriers.

[0017] In one embodiment of the present invention, the total weight percentage of bactericidal active ingredients in the bactericide is 1-80%, preferably 5-60%, and more preferably 5-50%.

[0018] In one embodiment of the present invention, the bactericide can be prepared into agriculturally usable formulations such as emulsifiable concentrates, wettable powders, water-dispersible granules, suspension concentrates, microemulsions, and water-in-oil emulsions, preferably prepared as suspension concentrates, water-dispersible granules, or wettable powders.

[0019] In this invention, the processing and preparation methods of the pesticide formulations are all well known to those skilled in the art, and the processing equipment used is also commonly used in pesticide formulation processing.

[0020] In one embodiment of the present invention, the agriculturally acceptable adjuvant and / or carrier includes one or more of the following: solvent, cosolvent, dispersant, wetting agent, emulsifier, thickener, binder, antifreeze, defoamer, stabilizer, disintegrant, and filler. Wherein: The solvent includes one or more of the following: dimethylformamide, dimethyl sulfoxide, acetone, xylene, dichloromethane, ethyl acetate, cyclohexane, cyclohexanone, N-methylpyrrolidone, coconut oil fatty acid methyl ester, cyclohexanol, methyl glycol ether, and acetonitrile.

[0021] The co-solvent includes one or more of methanol, ethanol, isopropanol, and n-butanol.

[0022] The dispersant comprises one or more of the following: lignin sulfonate, nonylphenol polyoxyethylene ether, polyoxyethylene alkyl aryl ether, polyoxyethylene lanolin alcohol, fatty alcohol polyoxyethylene ether, fatty alcohol polyoxyethylene ether phosphate, alkyl naphthalene sulfonate, sodium salt of naphthalene sulfonic acid formaldehyde condensate, sodium p-hydroxyphenyl lignin sulfonate, fatty alcohol polyoxyethylene ether sulfate, alkylphenol polyoxyethylene ether formaldehyde condensate, alkyl dimethyl benzyl ammonium salt, p-methoxy fatty amide benzene sulfonic acid, p-methoxy fatty amide benzene sulfonate, and polyoxyethylene sorbitan fatty acid ester.

[0023] The wetting agent includes one or more of the following: sodium dodecyl sulfate, calcium dodecylbenzene sulfonate, sodium lauroyl sarcosinate, fatty alcohol polyoxyethylene ether, dioctyl sulfosuccinate, polyoxyethylene alkyl aryl ether phosphate, trisiloxane polyoxyethylene ether, sodium isooctyl succinate sulfonate, sodium oleoyl methyl taurate, triphenylethylphenol polyoxyethylene ether, castor oil polyoxyethylene ether, polyoxyethylene fatty acid ester, and sorbitan fatty acid ester.

[0024] The emulsifier includes one or more of the following: lignin sulfonate, sodium dodecyl sulfate, sodium dodecylbenzene sulfonate, calcium dodecylbenzene sulfonate, naphthalene sulfonate formaldehyde condensate, styrene-phenyl polyoxyethylene ether, fatty alcohol polyoxyethylene ether, polyoxyethylene alkyl ether, polyoxyethylene sorbitan fatty acid ester, nonylphenol polyoxyethylene ether phosphate, styrene polyoxyethylene ether ammonium sulfate, sorbitan monostearate, and dehydrated sorbitan monostearate polyoxyethylene ether.

[0025] The thickener includes one or more of the following: carboxymethyl cellulose, sodium carboxymethyl cellulose, gum arabic, xanthan gum, gelatin, magnesium aluminum silicate, and sodium alginate.

[0026] The adhesive includes one or more of gum arabic, xanthan gum, starch, carboxymethyl cellulose, carboxyethyl cellulose, and gelatin.

[0027] The antifreeze includes one or more of ethylene glycol, propylene glycol, glycerol, and polyethylene glycol.

[0028] The defoamer includes one or more of the following: butyl phosphate, isobutyl phosphate, n-octanol, and silicone.

[0029] The stabilizer includes one or more of the following: triphenyl phosphite, epoxidized soybean oil, epoxidized linseed oil, dialkyl succinate sulfonate, butyl glycidyl ether, etc.

[0030] The disintegrant includes one or more of the following: sodium bicarbonate, ammonium sulfate, sodium carboxymethyl starch, sodium sulfate, calcium sulfate, and urea.

[0031] The filler / carrier includes solid filler / carrier and liquid filler / carrier, specifically including one or more of the following: kaolin, bentonite, diatomaceous earth, attapulgite, montmorillonite, calcium carbonate, clay, water, soybean oil, corn oil, castor oil, rapeseed oil, and mineral oil.

[0032] Another aspect of the present invention relates to the use of the bactericidal active ingredient composition or the fungicide of the present invention for the prevention and control of agricultural diseases. Specifically, the bactericidal active ingredient composition or the fungicide is brought into contact with the agricultural crop / plant or the pathogenic microorganism causing the agricultural disease before or after the occurrence of the agricultural disease.

[0033] Applicable crops / plants include: corn, rice, wheat, barley, rye, oats, sorghum, cotton, soybeans, mung beans, kidney beans, peanuts, buckwheat, sugar beets, rapeseed, sunflowers, sugarcane, tobacco, eggplant, tomatoes, potatoes, cucumbers, pumpkins, zucchini, watermelons, winter melons, turnips, cabbage, kale, broccoli, apples, pears, peaches, plums, apricots, etc. Wheat and rice are preferred.

[0034] Agricultural diseases that can be controlled include those commonly occurring on the crops, such as those caused by Oomycetes fungi (e.g., *Plasmodiophora*). Plasmodium phylum ), genus Arachycetes ( Physoderma ), Saprolegnia ( Saprolegnia ), genus Amygdalina ( Achlya ), Pythium ( Pythium Phytophthora ( ) Phytophthora ), genus *Peronospora* Downy mildew ), genus Pseudomonas ( Downy mildew ), Monopodial molds ( Plasmopara ), genus *Platycodon* ( Bremen ), Genus *Dactylogyrus* Sclerospora Diseases caused by fungi of the Zygomycota (such as Rhizopus genus); diseases caused by fungi of the Zygomycota (such as Rhizopus genus). Rhizopus Mucor ( ) I am sick. ), genus *Pterocarya* Absidia ), genus *Cereus* ( Choanephora Diseases caused by fungi of the Ascomycota (such as the genus *Exocystis*). Taphrina ), Fungiales ( Eurotiales Aspergillus ( ) Aspergillus ), Penicillium ( Penicillium ), Powdery mildew ( Flower shop ), Monofilamentae ( Spheroid ), genus *Cyclocarya* ( Podosphere Powdery mildew ( Erysipelas ), genus *Cypripedium* Microsphere ), genus *Hylocereus* Hook ), genus *Symplocos* ( Phylactinia ), Long-beaked Shell ( Ceratocystis ), Gibberellins ( Gibberella ), Black Rot Species ( Waltz ), genus Cocci ( Mycosphaerella ), Coccidioides ( Guignard ), Black Star Fungus ( Ventura ), genus *Streptococcus* Monilinia asexual state is Necklaces ), Sclerotium genus ( Sclerotinia Diseases caused by fungi of the Basidiomycota (such as *Phyllostachys* genus); diseases caused by fungi of the Basidiomycota phylum (such as *Phyllostachys* genus). Powdery mildew ), genus *Russula* ( Gymnosporangium ), genus *Scattered rust* ( Melampsora ), genus Laminaria ( Phakopsora ), Ustilago maydis genus ( I burn. ), genus *Solanum* Tilletia ), smut fungi ( Sphacelotheca ), genus *Septata* ( Septobasidium ), Exobasidiomycetes ( Exobasidium ), genus *Apocynum* Thanatephorus Armillaria mellea ( Armillaria Diseases caused by fungi (such as Rhizoctonia spp.) within the Deuteromycetes; diseases caused by fungi of the Deuteromycetes (such as Rhizoctonia spp.). Rhizoctonia ), Sclerotium genus ( Sclerotium ), genus *Platymonas* ( Necklaces ), genus *Pyrrosia* Oedipus ), Botrytis ( Botrytis ), genus *Pseudomonas* Ramularia ), Pyreus genus ( Firefly ), Penicillium ( Penicillium Aspergillus ( ) Aspergillus ), Verticillium ( Verticillium wilt Cercospora ( Cercospora Alternaria, Cladosporium Cladosporium ), Black Star Spore ( Sword ), genus *Helicobacter* ( Drechslera ), Helicobacterium genus ( Bipolar ), genus Helicobacter ( Exerohyl Diseases caused by Fusarium graminearum, etc. Preferred for the control of wheat scab (Fusarium graminearum). Fusarium gramineae Rice sheath blight (Rhizoctonia solani) Rhizoctonia solani )).

[0035] In the applications described in this invention, the application method, timing, and dosage of the bactericidal active ingredient composition or bactericide are all determined by those skilled in the art.

[0036] Another aspect of the present invention relates to a method for using the bactericidal active ingredient composition or the bactericide of the present invention to control agricultural diseases. Specifically, the bactericidal active ingredient composition or the bactericide is brought into contact with the agricultural crop / plant or the pathogenic microorganism causing the agricultural disease before or after the occurrence of the agricultural disease.

[0037] In the method described in this invention, the applicable crops / plants and the agricultural diseases used for prevention and control are the same as those described above.

[0038] Beneficial effects The fungicidal composition containing thiamethoxam and Inpyrfluxam described in this invention exhibits a significant synergistic effect in the prevention and control of agricultural diseases, especially wheat scab and rice sheath blight. Detailed Implementation

[0039] The present invention will be further described below with reference to embodiments, but the present invention is not limited thereto.

[0040] All reagents used in the following embodiments of the present invention can be obtained commercially or in-house. The plant pathogenic fungi used were either cultured in the laboratory or collected from the field. Furthermore, unless otherwise specified, all percentages mentioned in the following embodiments are weight percentages.

[0041] I. Combined toxicity test 1. Determination of the combined virulence of thiamethoxam and inpyrfluxam against Fusarium graminearum, the causal agent of wheat blight. Tested pathogenic fungus: Fusarium graminearum ( Fusarium gramineae This bacterium is the pathogen that causes wheat scab.

[0042] Test reagents: Thiamethoxam technical grade, Inpyrfluxam technical grade.

[0043] Experimental method: The toxicity of the agent to the pathogenic fungus was determined by the growth rate method, referring to the agricultural industry standard NY / T1156.2006.

[0044] Prepare a stock solution of the drug, then mix it according to the predetermined ratio in Table 1. Prepare seven concentration gradients using an aqueous solution containing 1% Tween-80, and then add it to PDA medium at 45-50℃, with a drug-to-medium volume ratio of 1:9. Mix thoroughly and pour into sterile petri dishes. After cooling, form drug-containing media with different concentration gradients. Each concentration is repeated three times. An aqueous solution containing 1% Tween-80 is used as a control. Then, under aseptic conditions, inoculate the pathogenic bacterial pellets into the center of the drug-containing media. Place the petri dishes in an incubator at 25±1℃ and approximately 85% humidity. When the colony radius on the control plate reaches approximately 2 / 3 of the plate radius, measure the colony diameter of each treatment using the cross-cross method, and calculate the growth inhibition rate of each drug treatment on the pathogen using the following formula, and determine the EC50 of each treatment on the pathogen. 50 .

[0045]

[0046] Then, following Sun Yunpei's method, the EC values ​​of each treatment were measured. 50 Convert to Actual Toxicity Index (ATI); calculate the Theoretical Toxicity Index (TTI) based on the formulation ratio of the mixture, and calculate the Co-toxicity Coefficient (CTC) of the mixture according to the following formula. The results are shown in Table 1 below.

[0047]

[0048]

[0049] =

[0050]

[0051]

[0052] If the co-toxicity coefficient is greater than 120, it indicates a synergistic effect; if the co-toxicity coefficient is less than 80, it indicates an antagonistic effect; if the co-toxicity coefficient is between 80 and 120, it indicates an additive effect.

[0053] Table 1 Results of Indoor Toxicity Measurement

[0054] Table 1 shows that thiamethoxam and Inpyrfluxam have a synergistic effect on Fusarium graminearum in the ratio range of 120:1 to 1:120. The co-toxicity coefficient is highest and the synergistic effect is most significant in the range of 7.5:1 to 1:1, which is the most preferred ratio range in this invention.

[0055] 2. Combined virulence determination of thiamethoxam and inpyrfluxam against rice sheath blight pathogen. Test pathogenic fungus: Rhizoctonia solani ( Rhizoctonia solani The pathogen is the cause of rice sheath blight.

[0056] Test reagents: Thiamethoxam technical grade, Inpyrfluxam technical grade.

[0057] Experimental Methods: The toxicity of the agent against the pathogenic fungus was determined using the growth rate method, referring to the agricultural industry standard NY / T1156.2006. The specific method was as described above. The results are shown in Table 2 below.

[0058] Table 2 Results of Indoor Toxicity Measurement

[0059] Table 2 shows that thiamethoxam and Inpyrfluxam have additive and synergistic effects against Rhizoctonia solani in the range of 120:1 to 1:120. In the range of 15:1 to 1:15, the co-toxicity coefficient is greater than 120, indicating a synergistic effect. Among these, the synergistic effect is most significant in the range of 7.5:1 to 1:1, which is the most preferred range of this invention.

[0060] II. Formulation Examples Example 1: 16% wettable powder (15:1) Thiamethoxam 15%, Inpyrfluxam 1%, Nonylphenol polyoxyethylene ether 4%, Calcium dodecylbenzenesulfonate 4%, Bentonite to make up to 100%.

[0061] The preparation method is as follows: the components are mixed, ground and pulverized to obtain a wettable powder.

[0062] Example 2: 20% wettable powder (1:1) Thiamethoxam 10%, Inpyrfluxam 10%, sodium fatty alcohol polyoxyethylene ether sulfate 3%, trisiloxane polyoxyethylene ether 5%, bentonite to make up to 100%.

[0063] The preparation method is the same as in Example 1.

[0064] Example 3: 8.5% suspension (1:7.5) Thiamethoxam 1%, Inpyrfluxam 7.5%, Sodium lignosulfonate 3%, Trisiloxane polyoxyethylene ether 3%, Sodium alginate 5%, Propylene glycol 5%, Silicone 0.5%, Water balance.

[0065] The preparation method is as follows: add each component to water, mix and stir, disperse by high-speed shearing and grinding to obtain a suspension.

[0066] Example 4: 8.5% suspension (7.5:1) Thiamethoxam 7.5%, Inpyrfluxam 1%, Fatty alcohol polyoxyethylene ether phosphate 4%, Sodium lauroyl sarcosinate 3%, Magnesium aluminum silicate 5%, Ethylene glycol 5%, Silicone 0.5%, Water balance.

[0067] The preparation method is the same as in Example 3.

[0068] Example 5: 18% water-dispersible granules (5:1) Thiamethoxam 15%, Inpyrfluxam 3%, fatty alcohol polyoxyethylene ether 5%, sodium oleoyl methyl taurate 3%, sodium sulfate 4%, carboxymethyl cellulose 4%, kaolin balance.

[0069] The preparation method involves mixing all components except the binder evenly and pulverizing them, then adding the binder aqueous solution to granulate, and drying to obtain water-dispersible granules.

[0070] Example 6: 16% water-dispersible granules (1:15) Thiamethoxam 1%, Inpyrfluxam 15%, polyoxyethylene sorbitan fatty acid ester 4%, triphenylethylphenol polyoxyethylene ether 4%, sodium sulfate 5%, gum arabic 5%, kaolin balance.

[0071] The preparation method is the same as in Example 5.

[0072] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, and not to limit them; although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some or all of the technical features; and these modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. A bactericidal active ingredient composition, characterized in that, The bactericidal active ingredient composition contains two active ingredients, thiamethoxam and Inpyrfluxam, with a weight ratio of thiamethoxam to Inpyrfluxam of 1:120 to 120:

1.

2. The bactericidal active ingredient composition according to claim 1, characterized in that, The preferred weight ratio of thiamethoxam to Inpyrfluxam is 1:60 to 60:

1.

3. A bactericide, characterized in that, The fungicide comprises the fungicide active ingredient composition according to any one of claims 1-2, and agriculturally acceptable adjuvants and / or carriers.

4. The bactericide according to claim 3, characterized in that, The total weight percentage of active ingredients in the bactericide is 1-80%.

5. The bactericide according to claim 3, characterized in that, The agriculturally acceptable adjuvants and / or carriers include one or more of the following: solvents, cosolvents, dispersants, wetting agents, emulsifiers, thickeners, binders, antifreeze agents, defoamers, stabilizers, disintegrants, and fillers.

6. The bactericide according to claim 3, characterized in that, The bactericide can be formulated as one or more of the following: emulsifiable concentrate, wettable powder, water-dispersible granules, suspension concentrate, microemulsion, and water-in-oil emulsion.

7. The use of the bactericidal active ingredient composition according to any one of claims 1-2 or the bactericide according to any one of claims 3-6 for the prevention and control of agricultural diseases, characterized in that, Before or after an agricultural disease occurs, the fungicidal active ingredient composition or the fungicide is brought into contact with the agricultural crop / plant or the pathogenic microorganism that causes the agricultural disease.

8. A method for controlling agricultural diseases using the bactericidal active ingredient composition according to any one of claims 1-2 or the bactericide according to any one of claims 3-6, characterized in that, Before or after an agricultural disease occurs, the fungicidal active ingredient composition or the fungicide is brought into contact with the agricultural crop / plant or the pathogenic microorganism that causes the agricultural disease.

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