Bactericidal composition containing benziothiazolinone and Fluoxyticonazole

Abstract

The invention provides a bactericidal active component composition containing benziothiazolinone and Fluoxyticonazole, wherein the weight ratio of the benziothiazolinone to the Fluoxyticonazole in the bactericidal active component composition is (1: 40) to (40: 1). The bactericidal composition disclosed by the invention has a synergistic effect on prevention and treatment of agricultural diseases within a limited ratio range. The invention also relates to a bactericide containing the bactericidal active ingredient composition, and a method and application of the bactericidal active ingredient composition or the bactericide for preventing and treating agricultural diseases.

Description

Technical Field

[0001] This invention belongs to the agricultural field, specifically relating to a bactericidal composition containing thiamethoxam and fluoxytioconazole and its application. Background Technology

[0002] Thiamethoxam (also known as 1,2-benzisothiazolin-3-one), belonging to the isothiazole heterocyclic compound class, is a novel, highly effective, low-toxicity, broad-spectrum fungicide. Its mechanism of action primarily involves binding to anions or sulfhydryl groups on the surface of pathogen cell membranes, disrupting the pathogen's nuclear structure, damaging protein and cell membrane synthesis systems, interfering with pathogen cell metabolism, inhibiting pathogen reproduction, and ultimately leading to pathogen death. This compound exhibits good control effects against bacterial and fungal diseases affecting crops.

[0003] Fluoxytioconazole is a novel triazole fungicide, commercially developed by Corteva, and belongs to the ergosterol biosynthesis inhibitor class. Fluoxytioconazole can be used on various crops such as wheat, corn, soybeans, peanuts, sunflowers, and cucumbers to control powdery mildew, rust, leaf blight, and other crop diseases. Tian Lei et al. (Synthesis and fungicidal activity of novel fungicide fluoxytioconazole, Pesticides, Vol. 63, No. 10) disclosed that Fluoxytioconazole can be used to control a variety of crop diseases, and studied its mechanism of action and biological activity.

[0004] Wheat powdery mildew is an important foliar disease caused by the obligate parasitic fungus *Erysiphe bryophyte*, a member of the Poaceae family. Its typical symptom is the appearance of powdery mildew spots on the green tissues of wheat leaves, leaf sheaths, and stems, initially white and later turning grayish-white. These spots are the mycelium and conidia of the pathogen. In severe cases, the lesions merge and cover the entire leaf surface, and small black dots (cleistothecia) may appear in the later stages. This disease mainly spreads through air currents, spreading conidia and infecting the plant. This leads to impaired photosynthesis, nutrient loss, premature leaf withering, and a decrease in thousand-grain weight, posing a serious threat to wheat yield and quality.

[0005] Currently, there are no reports of existing technologies involving the combination of thiamethoxam and Fluoxytioconazole. Summary of the Invention

[0006] The purpose of this invention is to screen effective compound agents for common but difficult-to-control diseases in agricultural production, such as wheat powdery mildew, using existing technologies. Through research, the inventors discovered that the combination of thiamethoxam and fluoxytioconazole has a significant synergistic effect, effectively controlling various agricultural diseases, including wheat powdery mildew. Based on this, this invention was completed.

[0007] One aspect of the present invention relates to a bactericidal active ingredient composition, wherein the bactericidal active ingredient composition contains two active ingredients: thiamethoxam and Fluoxytioconazole.

[0008] In the bactericidal active ingredient composition of the present invention, the weight ratio of thiamethoxam to fluoxytioconazole is 1:40 to 40:1, preferably 1:20 to 20:1. For example: 20:1, 19:1, 18:1, 17:1, 16:1, 15:1, 14:1, 13:1, 12:1, 11:1, 10:1, 9:1, 8:1, 7:1, 6:1, 5:1, 4:1, 3:1, 2:1, 1:1, 1:2, 1:3, 1:4, 1:5, 1:6, 1:7, 1:8, 1:9, 1:10, 1:11, 1:12, 1:13, 1:14, 1:15, 1:16, 1:17, 1:18, 1:19, 1:20.

[0009] In a preferred embodiment of the present invention, the weight ratio of thiamethoxam to Fluoxytioconazole is further preferably 10:1 to 1:10, and even more preferably 1:1 to 1:5.

[0010] In addition to the two active ingredients, thiamethoxam and fluoxytioconazole, the bactericidal active ingredient composition of the present invention may also contain other known bactericides, such as: Triazoles: Tebuconazole, Hexaconazole, Propiconazole, Prothioconazole, Triadimefon, Bisbenzyltriazole, Cycloconazole, Tebuconazole, Zimbabenazole, Oxytetracycline, Cyproconazole, Flusilazole, Tebuconazole, Cycloconazole, Paclobutrazol, Tebuconazole, Silozoline, Flufenoxuron; Methoxyacrylates: azoxystrobin, pyraclostrobin, oxadiazon, pyraclostrobin, difenoconazole, cyproconazole, pyraclostrobin; Carboxamides; Benzoyl sulfadiazine, Benzoyl sulfadiazine, Mefenoxam, Cyclopyralid, Cyclopyralid, Fluopyram, Furazolidone, Isothiazamide, Propyrazosulfuron, Metalaxyl, Metalaxyl-M, Mefenoxam, Bromofluopyram, Fluopyram, Thiamethoxam; Carboxymorpholines: dimethomorpholine, flumethomorpholine; Benzimidazoles: Carbendazim, Benomyl, Thiamethoxam, Mefenoxam, Thiamethoxam; Dicarboxyimide derivatives: iprodione, procymidone, vinclozolin; Amides: thiamethoxam, flumorpholine, dimethomorpholine, silthiamethoxam, chlorpyrifos; Pyrroles: Seed dressing pyrrole, fludioxonil; Pyrimidine derivatives: pyrimethanil, fluazolidinium, sulfadiazine, cyprodinil, fluazolidinium, isopyram, pyrimethanil, pyrimethanil, chlorpyrifos, chlorpyrifos, dimethoprim; Carbamates: Mancozeb, Mancozeb, Mancozeb, Mancozeb, Mancozeb, Zinc thiram, Mancozeb, Zinc thiram; Organochlorine compounds: chlorothalonil, bacteriostatic agent, dichlorophenol, sulfadiazine, hexachlorobenzene, pendimethalin, pentachlorophenol and its salts, tetrachlorophthalide, pentachloronitrobenzene, methyl thiophanate.

[0011] In a preferred embodiment of the present invention, the bactericidal active ingredient composition consists of only two active ingredients: thiamethoxam and Fluoxytioconazole.

[0012] In this invention, the combination of thiamethoxam and fluoxytioconazole, two active ingredients, exhibits a significant synergistic effect in the control of agricultural diseases. This synergistic effect is particularly pronounced in the control of wheat powdery mildew, making it the preferred formulation of this invention.

[0013] Another aspect of the present invention relates to a fungicide, wherein the fungicide comprises the fungicide active ingredient composition described in the present invention, and agriculturally acceptable adjuvants and / or carriers.

[0014] In one embodiment of the present invention, the total weight percentage of bactericidal active ingredients in the bactericide is 1-80%, preferably 5-60%, and more preferably 10-50%.

[0015] In one embodiment of the present invention, the bactericide can be prepared into agriculturally usable formulations such as emulsifiable concentrates, wettable powders, water-dispersible granules, suspension concentrates, microemulsions, and water-in-oil emulsions, preferably prepared as a suspension concentrate.

[0016] In this invention, the processing and preparation methods of the pesticide formulations are all well known to those skilled in the art, and the processing equipment used is also commonly used in pesticide formulation processing.

[0017] In one embodiment of the present invention, the agriculturally acceptable adjuvant and / or carrier includes one or more of the following: solvent, cosolvent, dispersant, wetting agent, emulsifier, thickener, binder, antifreeze, defoamer, stabilizer, disintegrant, and filler. Wherein: The solvent includes one or more of the following: dimethylformamide, dimethyl sulfoxide, acetone, xylene, dichloromethane, ethyl acetate, cyclohexane, cyclohexanone, N-methylpyrrolidone, coconut oil fatty acid methyl ester, cyclohexanol, methyl glycol ether, and acetonitrile.

[0018] The co-solvent includes one or more of methanol, ethanol, isopropanol, and n-butanol.

[0019] The dispersant comprises one or more of the following: lignin sulfonate, nonylphenol polyoxyethylene ether, polyoxyethylene alkyl aryl ether, polyoxyethylene lanolin alcohol, fatty alcohol polyoxyethylene ether, fatty alcohol polyoxyethylene ether phosphate, alkyl naphthalene sulfonate, sodium salt of naphthalene sulfonic acid formaldehyde condensate, sodium p-hydroxyphenyl lignin sulfonate, fatty alcohol polyoxyethylene ether sulfate, alkylphenol polyoxyethylene ether formaldehyde condensate, alkyl dimethyl benzyl ammonium salt, p-methoxy fatty amide benzene sulfonic acid, p-methoxy fatty amide benzene sulfonate, and polyoxyethylene sorbitan fatty acid ester.

[0020] The wetting agent includes one or more of the following: sodium dodecyl sulfate, calcium dodecylbenzene sulfonate, sodium lauroyl sarcosinate, fatty alcohol polyoxyethylene ether, dioctyl sulfosuccinate, polyoxyethylene alkyl aryl ether phosphate, trisiloxane polyoxyethylene ether, sodium isooctyl succinate sulfonate, sodium oleoyl methyl taurate, triphenylethylphenol polyoxyethylene ether, castor oil polyoxyethylene ether, polyoxyethylene fatty acid ester, and sorbitan fatty acid ester.

[0021] The emulsifier includes one or more of the following: lignin sulfonate, sodium dodecyl sulfate, sodium dodecylbenzene sulfonate, calcium dodecylbenzene sulfonate, naphthalene sulfonate formaldehyde condensate, styrene-phenyl polyoxyethylene ether, fatty alcohol polyoxyethylene ether, polyoxyethylene alkyl ether, polyoxyethylene sorbitan fatty acid ester, nonylphenol polyoxyethylene ether phosphate, styrene polyoxyethylene ether ammonium sulfate, sorbitan monostearate, and dehydrated sorbitan monostearate polyoxyethylene ether.

[0022] The thickener includes one or more of the following: carboxymethyl cellulose, sodium carboxymethyl cellulose, gum arabic, xanthan gum, gelatin, magnesium aluminum silicate, and sodium alginate.

[0023] The adhesive includes one or more of gum arabic, xanthan gum, starch, carboxymethyl cellulose, carboxyethyl cellulose, and gelatin.

[0024] The antifreeze includes one or more of ethylene glycol, propylene glycol, glycerol, and polyethylene glycol.

[0025] The defoamer includes one or more of the following: butyl phosphate, isobutyl phosphate, n-octanol, and silicone.

[0026] The stabilizer includes one or more of the following: triphenyl phosphite, epoxidized soybean oil, epoxidized linseed oil, dialkyl succinate sulfonate, butyl glycidyl ether, etc.

[0027] The disintegrant includes one or more of the following: sodium bicarbonate, ammonium sulfate, sodium carboxymethyl starch, sodium sulfate, calcium sulfate, and urea.

[0028] The filler / carrier includes solid filler / carrier and liquid filler / carrier, specifically including one or more of the following: kaolin, bentonite, diatomaceous earth, attapulgite, montmorillonite, calcium carbonate, clay, water, soybean oil, corn oil, castor oil, rapeseed oil, and mineral oil.

[0029] In one embodiment of the present invention, the bactericide is preferably prepared as a suspension. The adjuvants used in the preparation of the suspension are as described above. In a preferred embodiment, in the preparation of the suspension, the dispersant is preferably nonylphenol polyoxyethylene ether, such as nonylphenol polyoxyethylene ether (10); the wetting agent is preferably sodium oleoyl methyl taurate, and the weight ratio of nonylphenol polyoxyethylene ether to sodium oleoyl methyl taurate is 1:1.2-1.5. Through formulation screening experiments, the inventors found that in the preparation of the suspension, when nonylphenol polyoxyethylene ether (such as nonylphenol polyoxyethylene ether (10)) is selected as the dispersant and sodium oleoyl methyl taurate is selected as the wetting agent, and the weight ratio of the two is 1:1.2-1.5, the suspension rate of the active ingredients thiamethoxam and Fluoxytioconazole in the bactericide can be significantly improved, which is very advantageous.

[0030] Another aspect of the present invention relates to the use of the bactericidal active ingredient composition or the fungicide of the present invention for the prevention and control of agricultural diseases. Specifically, the bactericidal active ingredient composition or the fungicide is brought into contact with the agricultural crop / plant or the pathogenic microorganism causing the agricultural disease before or after the occurrence of the agricultural disease.

[0031] Applicable crops / plants include: corn, rice, wheat, barley, rye, oats, sorghum, cotton, soybeans, mung beans, kidney beans, peanuts, buckwheat, sugar beets, rapeseed, sunflowers, sugarcane, tobacco, eggplant, tomatoes, potatoes, cucumbers, pumpkins, zucchini, watermelons, winter melons, turnips, Chinese cabbage, kale, broccoli, apples, pears, peaches, plums, apricots, etc. Wheat is preferred.

[0032] Agricultural diseases that can be controlled include those commonly occurring on the crops, such as those caused by Oomycetes fungi (e.g., *Plasmodiophora*). Plasmodium phylum ), genus Arachycetes ( Physoderma ), Saprolegnia ( Saprolegnia ), genus Amygdalina ( Achlya ), Pythium ( Pythium Phytophthora ( ) Phytophthora ), genus *Peronospora* Downy mildew ), genus Pseudomonas ( Downy mildew ), Monopodial molds ( Plasmopara ), genus *Platycodon* ( Bremen ), Genus *Dactylogyrus* SclerosporaDiseases caused by fungi of the Zygomycota (such as Rhizopus genus); diseases caused by fungi of the Zygomycota (such as Rhizopus genus). Rhizopus Mucor ( ) I am sick. ), genus *Pterocarya* Absidia ), genus *Cereus* ( Choanephora Diseases caused by fungi of the Ascomycota (such as the genus *Exocystis*). Taphrina ), Fungiales ( Eurotiales Aspergillus ( ) Aspergillus ), Penicillium ( Penicillium ), Powdery mildew ( Flower shop ), Monofilamentae ( Spheroid ), genus *Cyclocarya* ( Podosphere Powdery mildew ( Erysipelas ), genus *Cypripedium* Microsphere ), genus *Hylocereus* ( Hook ), genus *Symplocos* ( Phylactinia ), Long-beaked Shell ( Ceratocystis ), Gibberellins ( Gibberella ), Black Rot Species ( Waltz ), genus Cocci ( Mycosphaerella ), Coccidioides ( Guignard ), Black Star Fungus ( Ventura ), genus *Streptococcus* Monilinia asexual state is Necklaces ), Sclerotium genus ( Sclerotinia Diseases caused by fungi of the Basidiomycota (such as *Phyllostachys* genus); diseases caused by fungi of the Basidiomycota phylum (such as *Phyllostachys* genus). Powdery mildew ), genus *Russula* ( Gymnosporangium ), genus *Scattered rust* ( Melampsora ), genus Laminaria ( Phakopsora ), Ustilago maydis genus ( I burn. ), genus *Solanum* Tilletia ), Ustilago maydis genus ( Sphacelotheca ), genus *Septata* ( Septobasidium ), Exobasidiomycetes ( Exobasidium ), genus *Apocynum* Thanatephorus Armillaria mellea ( Armillaria Diseases caused by fungi (such as Rhizoctonia spp.) within the Deuteromycetes; diseases caused by fungi of the Deuteromycetes (such as Rhizoctonia spp.). Rhizoctonia ), Sclerotium genus ( Sclerotium ), genus *Platymonas* ( Necklaces ), genus *Pyrrosia* Oedipus ), Botrytis ( Botrytis ), genus *Pseudomonas* Ramularia ), Pyreus ( Firefly ), Penicillium ( Penicillium Aspergillus ( ) Aspergillus ), Verticillium ( Verticillium wilt Cercospora ( Cercospora Alternaria, Cladosporium Cladosporium ), Black Star Spore ( Sword ), genus *Helicobacter* ( Drechslera ), Helicobacterium genus ( Bipolar ), genus Helicobacter ( Exerohyl Diseases caused by *Phyllostachys edulis* (a type of fungus). Preferred for the control of wheat powdery mildew (*Phyllostachys edulis*). Flowering grass f. sp. tritici)).

[0033] In the applications described in this invention, the application method, timing, and dosage of the bactericidal active ingredient composition or bactericide are all determined by those skilled in the art.

[0034] Another aspect of the present invention relates to a method for using the bactericidal active ingredient composition or the bactericide of the present invention to control agricultural diseases. Specifically, the bactericidal active ingredient composition or the bactericide is brought into contact with the agricultural crop / plant or the pathogenic microorganism causing the agricultural disease before or after the occurrence of the agricultural disease.

[0035] In the method described in this invention, the applicable crops / plants and the agricultural diseases used for prevention and control are the same as those described above.

[0036] Beneficial effects The fungicidal composition containing thiamethoxam and fluoxytioconazole described in this invention exhibits a significant synergistic effect in the prevention and control of agricultural diseases, especially wheat powdery mildew. Detailed Implementation

[0037] The present invention will be further described below with reference to embodiments, but the present invention is not limited thereto.

[0038] All reagents used in the following embodiments of the present invention can be obtained commercially available or in-house. Furthermore, unless otherwise specified, all percentages mentioned in the following embodiments are weight percentages.

[0039] I. Combined toxicity test The combined toxicity of thiamethoxam and fluoxytioconazole against wheat powdery mildew was determined by pot experiment (referencing agricultural industry standard NY / T 1156.4-2006).

[0040] Tested pathogenic fungus: Powdery mildew (Phyllostachys bryony) Flowering grass f. sp. tritici) is the pathogen that controls wheat powdery mildew. Fresh spores of the pathogen are collected from diseased wheat leaves.

[0041] Test reagents: Thiamethoxam technical grade, Fluoxytioconazole technical grade. Prepare stock solutions of the reagents, then mix them according to the predetermined proportions in Table 1, and prepare 5 concentration gradients with an aqueous solution containing 1% Tween-80 for later use.

[0042] Experimental Methods: Two- to three-leaf stage wheat plants were selected and grown in pots in the laboratory. The pesticide was sprayed evenly onto the wheat plants using a spraying method until the leaves were just completely moistened, and then allowed to air dry. A control group (1% Tween-80 aqueous solution) without pesticide was included. 24 hours after pesticide treatment, fresh powdery mildew spores were collected and evenly inoculated onto the two- to three-leaf stage potted wheat seedlings. At least six pots were used per treatment, with ten seedlings per pot. The plants were then placed in alternating light / dark conditions for 12 hours each, at a temperature of 20±1℃ and a relative humidity of 90%. Each treatment was replicated three times.

[0043] Seven days after the onset of illness, the incidence of illness in the control group was graded according to the classification method. The following classification method was used: Level 0: No disease; Grade 1: The area of ​​lesions accounts for less than 5% of the total leaf area; Grade 3: The lesion area accounts for 6% to 15% of the total leaf area; Level 5: The lesion area accounts for 16%-25% of the total leaf area; Level 7: The lesion area accounts for 26% to 50% of the total leaf area; Level 9: The lesion area accounts for more than 50% of the total leaf area.

[0044] Based on the survey results, the disease index and prevention and control effects of each treatment were calculated:

[0045]

[0046] Regression analysis was performed based on the logarithmic values ​​of each drug concentration and the corresponding efficacy probability values ​​to calculate the EC50 of each drug. 50 Then, following Sun Yunpei's method, the EC values ​​for each treatment were measured. 50 Convert to Actual Toxicity Index (ATI); calculate the Theoretical Toxicity Index (TTI) based on the formulation ratio of the mixture, and calculate the Co-toxicity Coefficient (CTC) of the mixture according to the following formula. The results are shown in Table 1 below.

[0047]

[0048]

[0049] =

[0050]

[0051]

[0052] If the co-toxicity coefficient is greater than 120, it indicates a synergistic effect; if the co-toxicity coefficient is less than 80, it indicates an antagonistic effect; if the co-toxicity coefficient is between 80 and 120, it indicates an additive effect.

[0053] Table 1 Results of Indoor Toxicity Measurement

[0054] Table 1 shows that thiamethoxam and fluoxytioconazole have a synergistic effect on wheat powdery mildew in the range of 40:1 to 1:40, and the synergistic effect is more obvious in the range of 10:1 to 1:10. In particular, the synergistic effect is most obvious in the range of 1:1 to 1:5, and the co-toxicity coefficient exceeds 150, which is the best choice of the invention.

[0055] II. Formulation Examples Example 1: Suspension Thiamethoxam 7%, Fluoxytioconazole 7%, Sodium lignosulfonate 4%, Trisiloxane polyoxyethylene ether 5%, Sodium carboxymethyl cellulose 3%, Propylene glycol 4%, Silicone 0.6%, Water balance.

[0056] The preparation method is as follows: The prescribed amounts of thiamethoxam, fluoxytioconazole, sodium lignosulfonate, trisiloxane polyoxyethylene ether, silicone and some water are added to a shear mill and dispersed and sheared at 1500 r / min for 30 min. Then, it is transferred to a sand mill, zirconia beads are added and it is ground at 500 r / min for 3 h. Then, the prescribed amounts of sodium carboxymethyl cellulose, propylene glycol and the remaining water are added and mixed evenly to obtain the suspension.

[0057] Example 2 Suspension Thiamethoxam 4%, Fluoxytioconazole 10%, Nonylphenol polyoxyethylene ether (10) 5%, Calcium dodecylbenzenesulfonate 3.5%, Magnesium aluminum silicate 5%, Propylene glycol 4%, Silicone 0.6%, Water balance.

[0058] The preparation method is the same as in Example 1.

[0059] Example 3 Suspension Thiamethoxam 2%, Fluoxytioconazole 10%, Nonylphenol polyoxyethylene ether (10) 3%, Sodium oleoyl methyl taurate 4%, Magnesium aluminum silicate 5%, Propylene glycol 4%, Silicone 0.6%, Water balance.

[0060] The preparation method is the same as in Example 1.

[0061] Example 4 Suspension Thiamethoxam 2%, Fluoxytioconazole 15%, Polyoxyethylene sorbitan fatty acid ester 5%, Sodium oleoyl methyl taurate 6%, Gum arabic 5%, Glycerol 4%, Silicone 0.6%, Water balance.

[0062] The preparation method is the same as in Example 1.

[0063] Example 5 Suspension Agent Thiamethoxam 1%, Fluoxytioconazole 10%, Sodium Naphthalenesulfonic Acid Formaldehyde Condensate 4%, Triphenylethylphenol Polyoxyethylene Ether 4%, Xanthan Gum 4%, Ethylene Glycol 4%, Silicone 0.6%, Water balance.

[0064] The preparation method is the same as in Example 1.

[0065] Then, the suspension rate of the prepared suspensions from Examples 1-5 was determined. The method for determining the suspension rate was as follows: 1 mL of the prepared suspension sample was added to a beaker containing 50 mL of standard hard water (342 mg / L) and stirred with a glass rod. Then, the entire sample was washed into a 250 mL graduated cylinder with standard hard water and diluted to the mark. The stopper was then placed on the cylinder, and the cylinder was inverted 30 times within 1 minute, with the bottom of the cylinder as the axis. The stopper was then opened, and the cylinder was placed vertically in a constant temperature water bath at 30°C for 30 minutes. Then, 9 / 10 (225 mL) of the contents was removed using a pipette. During the aspiration, the pipette was moved down along the inner wall of the graduated cylinder as the liquid level dropped to avoid disturbing the lower sediment. The content of the active ingredient in the sample and the 25 mL of suspension remaining at the bottom of the graduated cylinder was determined. The experiment was repeated in triplicate. The suspension rate of the sample was calculated according to the following formula: Suspension rate = [(m1-m2) / m1] × (10 / 9) In the formula: m1 represents the mass of the effective component in the suspension sample; m2 represents the mass of the active ingredient remaining in the 25 mL suspension at the bottom of the graduated cylinder; The results are shown in Table 2 below.

[0066] Table 2 Results of suspension rate determination

[0067] It is easy to see from the results in Table 2 that the suspension rates of the suspending agents prepared in this invention are generally greater than 80%. However, in Example 3, when 3% nonylphenol polyoxyethylene ether (10) is used as the dispersant and 4% sodium oleoyl methyl taurate is used as the wetting agent, the suspension rates of the active ingredients thiamethoxam and Fluoxytioconazole can both reach more than 98%. This formulation is the preferred one in this invention.

[0068] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, and not to limit them; although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some or all of the technical features; and these modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. A bactericidal active ingredient composition, characterized in that, The bactericidal active ingredient composition contains two active ingredients, thiamethoxam and Fluoxytioconazole, with a weight ratio of thiamethoxam to Fluoxytioconazole of 1:40 to 40:

1.

2. The bactericidal active ingredient composition according to claim 1, characterized in that, The preferred weight ratio of thiamethoxam to Fluoxytioconazole is 1:20 to 20:

1.

3. A bactericide, characterized in that, The fungicide comprises the fungicide active ingredient composition according to any one of claims 1-2, and agriculturally acceptable adjuvants and / or carriers.

4. The bactericide according to claim 3, characterized in that, The total weight percentage of active ingredients in the bactericide is 1-80%.

5. The bactericide according to claim 3, characterized in that, The agriculturally acceptable adjuvants and / or carriers include one or more of the following: solvents, cosolvents, dispersants, wetting agents, emulsifiers, thickeners, binders, antifreeze agents, defoamers, stabilizers, disintegrants, and fillers.

6. The bactericide according to claim 3, characterized in that, The bactericide can be formulated as one or more of the following: emulsifiable concentrate, wettable powder, water-dispersible granules, suspension concentrate, microemulsion, and water-in-oil emulsion.

7. The bactericide according to claim 6, characterized in that, The bactericide is preferably formulated as a suspension.

8. The use of the bactericidal active ingredient composition according to any one of claims 1-2 or the bactericide according to any one of claims 3-7 for the prevention and control of agricultural diseases, characterized in that, Before or after an agricultural disease occurs, the fungicidal active ingredient composition or the fungicide is brought into contact with the agricultural crop / plant or the pathogenic microorganism that causes the agricultural disease.

9. A method for controlling agricultural diseases using the bactericidal active ingredient composition according to any one of claims 1-2 or the bactericide according to any one of claims 3-7, characterized in that, Before or after an agricultural disease occurs, the fungicidal active ingredient composition or the fungicide is brought into contact with the agricultural crop / plant or the pathogenic microorganism that causes the agricultural disease.

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