Epoxy azoxystrobin nano suspending agent as well as preparation method and application thereof

Abstract

The invention provides an epoxiconazole azoxystrobin nano suspending agent as well as a preparation method and application thereof, and belongs to the technical field of pesticides. The epoxiconazole and azoxystrobin nano suspending agent is prepared from the following components in percentage by mass: 5 to 20 percent of epoxiconazole, 10 to 30 percent of azoxystrobin, 2 to 5 percent of a wetting agent, 6 to 12 percent of a dispersing agent, 0.2 to 2 percent of a thickening agent, 1 to 5 percent of an anti-freezing agent, 0.01 to 0.5 percent of a preservative, 0.1 to 2 percent of a de-foaming agent and the balance of water. The epoxiconazole and azoxystrobin nano suspending agent is prepared by compounding epoxiconazole and azoxystrobin, has good particle size stability (the particle size D90 is less than or equal to 500nm), and can keep good particle size over-time stability under a low dilution multiple (within 100 times). The nano suspending agent can significantly enhance the prevention and treatment effect on fungal diseases, expand the prevention and treatment spectrum, delay the development of resistance to a single effective component, adapt to flight control pesticide application, and can give full play to the use advantages of the nano suspending agent.

Description

Technical Field

[0001] This invention relates to the field of pesticide technology, and in particular to a fluopyram nano-suspension agent, its preparation method, and its application. Background Technology

[0002] Suspension concentrates are multiphase dispersion systems formed by dispersing and homogenizing solid active ingredients and various adjuvants that are slightly soluble or insoluble in water in an aqueous medium. They are thermodynamically unstable systems. In 54℃ thermal storage tests, the Austronesian ripening effect typically causes a certain increase in the particle size of the active ingredient during the test. Nano-suspension concentrates, due to their smaller particle size, exhibit greater solubility of the active ingredient in the aqueous medium, thus exacerbating the Austronesian ripening effect and making it easier for D... 98 Particles larger than 1000 nm cannot exert the excellent effects of nano-formulations.

[0003] Due to their smaller particle size, nano-suspensions have better permeability than conventional suspensions. Therefore, while retaining the advantages of suspension production and use (such as no dust and no organic solvents), they can improve the utilization rate and speed of action of the agent, thereby enhancing the efficacy of prevention.

[0004] In current agricultural production, aerial spraying is becoming increasingly important, and the long-term stability of the formulations at low dilutions (20-100 times) directly affects the application effect. This is especially true for nano-suspensions; maintaining particle size within the nanometer range at low dilutions is crucial for achieving superior performance compared to ordinary suspensions. At low dilutions, on the one hand, the concentration of some adjuvants falls below the CMC value, hindering their dispersion and wetting functions. On the other hand, the decreased thickener concentration disrupts the three-dimensional network within the system, while the higher particle concentration intensifies inter-particle collisions, making it easier to overcome energy barriers and form larger particle clusters.

[0005] Currently, both flutriafol and azoxystrobin exist as single-agent nano-suspensions. For example, patent CN118511877A provides a flutriafol nano-suspension and its preparation method, which includes particle size stability testing during storage but not particle size stability testing under low-dilution conditions for aerial application. Patent CN102626084A relates to an azoxystrobin nano-aqueous suspension, but does not cover particle size stability testing during storage or under low-dilution conditions for aerial application. However, there are no reports on nano-suspensions combining flutriafol and azoxystrobin.

[0006] Therefore, there is an urgent need for a fluopyram nano-suspension agent with small particle size, good thermal storage stability, and good particle size stability after low-fold dilution. Summary of the Invention

[0007] The purpose of this invention is to provide a fluopyram nano-suspension agent, its preparation method, and its application. The fluopyram nano-suspension agent has a small particle size (particle size D). 90 (≤500nm), good thermal storage stability, and good particle size stability after low-fold dilution.

[0008] To achieve the above-mentioned objectives, the present invention provides the following technical solution: This invention provides a fluopyram nano-suspension agent, comprising the following components by weight percentage: Flutriafol 5-20%, azoxystrobin 10-30%, wetting agent 2-5%, dispersant 6-12%, thickener 0.2-2%, antifreeze 1-5%, preservative 0.01-0.5%, defoamer 0.1-2%, balance water; The dispersant comprises alkylphenol polyoxyethylene ether formaldehyde condensate sulfonate and block polyether phosphate.

[0009] Preferably, the alkylphenol polyoxyethylene ether formaldehyde condensate is Dispersogen 1494 liq; the block polyether phosphate is CF-20S; and the mass ratio of Dispersogen 1494 liq to CF-20S is 1:3 to 3:1.

[0010] Preferably, the wetting agent comprises one or both of block polyethers and C8-C14 fatty alcohol ethoxypropoxyides.

[0011] Preferably, the block polyether is AGRIGEN B848; and the C8-C14 fatty alcohol ethoxypropoxylate is T80.

[0012] Preferably, the thickener comprises one or both of magnesium aluminum silicate and xanthan gum.

[0013] Preferably, the antifreeze includes at least one of ethylene glycol, glycerol, and propylene glycol.

[0014] Preferably, the preservative includes at least one of sodium benzoate and Kathon.

[0015] Preferably, the defoamer is an organosilicon defoamer.

[0016] This invention provides a method for preparing the fluopyram nano-suspension described in the above technical solution, comprising the following steps: Dispersant, wetting agent, antifreeze, and part of defoamer are mixed with water to obtain the first mixture; Azoxystrobin and flutriafol were mixed with the first mixture and homogenized to obtain the second mixture. After coarse grinding of the second mixture, it is subjected to staged cyclic grinding until the material particle size D is reached.90 ≤500nm, to obtain the third mixture; The third mixture is mixed with thickener, preservative and remaining defoamer, and homogenized for the second time to obtain fluopyram nano-suspension.

[0017] This invention provides the application of the fluopyram nano-suspension agent described in the above-described technical solution or the fluopyram nano-suspension agent prepared by the above-described preparation method in the field of pesticides.

[0018] This invention provides a fluopyram nano-suspension agent, wherein the effective component particles of the fluopyram nano-suspension agent have a particle size D. 90 With a particle size ≤500nm, it exhibits excellent particle size stability. Through the combined action of two specific dispersants, alkylphenol polyoxyethylene ether formaldehyde condensate sulfonate and block polyether phosphate, the steric hindrance effect provided by the polymer compounds and the electrostatic steric hindrance effect provided by the anions can solve the problem of particle size growth during thermal storage, thereby improving thermal storage stability. Furthermore, due to the different molecular weights of the two dispersants, a complementary effect exists during the adsorption of the active ingredient particles, allowing for more adsorption sites on the particle surface, enhancing inter-particle steric hindrance, and reducing the tendency for particle aggregation. Therefore, it can ensure particle size stability during thermal storage, while simultaneously solving problems such as increased specific surface area and easy paste formation caused by small particle size. Moreover, it can maintain particle size stability for a longer period at low dilution ratios, meeting the needs of aerial spraying operations.

[0019] In addition, the dispersant CF-20S used in this invention is a block polyether phosphate. Due to its long carbon chain and unique structural design, it has a low CMC value while enabling the suspending agent to have good thixotropy. At the same time, its diluted solution also has a certain thixotropy within a wide dilution range (within 100 times dilution). Thus, the particle size of the suspending agent can still maintain good long-term stability and remain within the nanometer range under low dilution conditions (20~100 times).

[0020] This nano-suspension agent can significantly enhance the control effect against fungal diseases, broaden the control spectrum, delay the development of resistance to single active ingredients, adapt to aerial spraying, and fully leverage the advantages of nano-suspension agents, thus possessing good commercial application value.

[0021] This invention improves the speed and efficacy of suspending agents against fungal diseases such as rice blast, while retaining the advantages of suspending agents such as high flash point, non-flammability and non-explosion, safe production, storage and use, low dust, low environmental pollution, and safety for producers, users and the environment. Detailed Implementation

[0022] In this invention, unless otherwise specified, the raw materials or reagents required for preparation are all commercially available products well known to those skilled in the art.

[0023] This invention provides a fluopyram nano-suspension agent, comprising the following components by weight percentage: Flutriafol 5-20%, azoxystrobin 10-30%, wetting agent 2-5%, dispersant 6-12%, thickener 0.2-2%, antifreeze 1-5%, preservative 0.01-0.5%, defoamer 0.1-2%, balance water; The dispersant comprises alkylphenol polyoxyethylene ether formaldehyde condensate sulfonate and block polyether phosphate.

[0024] The flutriafol nano-suspension provided by this invention comprises 5-20% flutriafol, preferably 10-15%, by weight percentage. This invention does not impose any special limitation on the source of the flutriafol; commercially available technical grade flutriafol known in the art is acceptable.

[0025] The flucyclopyrrolidone nano-suspension provided by this invention comprises 10-30% flucyclopyrrolidone, preferably 15-25%, and more preferably 16-20% flucyclopyrrolidone, by weight percentage. This invention does not impose any special limitation on the source of the flucyclopyrrolidone; commercially available technical grade pesticides well-known in the art are acceptable.

[0026] The fluopyram nano-suspension provided by the present invention comprises 2-5% wetting agent, more preferably 3-4%, by weight percentage.

[0027] In this invention, the wetting agent preferably includes one or both of block polyether and C8-C14 fatty alcohol ethoxypropoxylate; the block polyether is preferably AGRIGEN B848 (preferably sourced from Shanghai Ruichuan International Trade Co., Ltd.); the C8-C14 fatty alcohol ethoxypropoxylate is preferably T80 (preferably sourced from Yuanqidian New Materials Technology (Shanghai) Co., Ltd.). When the wetting agent is either of the above two types, this invention does not impose any special limitation on the ratio of the two wetting agents, and any ratio is acceptable.

[0028] The fluopyram nano-suspension provided by the present invention comprises 6-12% dispersant, preferably 7-10%, and more preferably 8-9%, by mass percentage.

[0029] In this invention, the dispersant comprises alkylphenol polyoxyethylene ether formaldehyde condensate sulfonate and block polyether phosphate; the alkylphenol polyoxyethylene ether formaldehyde condensate sulfonate is preferably Dispersogen 1494 liq (preferably sourced from Shanghai Ruichuan International Trade Co., Ltd.); the block polyether phosphate is preferably CF-20S (preferably sourced from Yuanqidian New Material Technology (Shanghai) Co., Ltd.); the mass ratio of Dispersogen 1494 liq to CF-20S is preferably 1:3 to 3:1, more preferably 1:2 to 2:1, and even more preferably 1:2.

[0030] The fluopyram nano-suspension agent provided by the present invention comprises 0.2-2% thickener, preferably 0.25-1.6%, and more preferably 0.5-1.2% by mass percentage.

[0031] In this invention, the thickener preferably includes one or both of magnesium aluminum silicate and xanthan gum. When the thickener is one or both of the above, this invention does not have a special limitation on the ratio of the two thickeners, and any ratio is acceptable. Xanthan gum is preferably prepared into a xanthan gum colloid using deionized water as a solvent. The concentration of xanthan gum in the xanthan gum colloid is preferably 0.5-2 wt%, more preferably 1-1.5 wt%, by mass percentage.

[0032] The fluopyram nano-suspension provided by the present invention comprises 1-5% antifreeze, preferably 2-4%, and more preferably 3% by mass percentage.

[0033] In this invention, the antifreeze preferably includes at least one selected from ethylene glycol, glycerol, and propylene glycol. When the antifreeze is two or more of the above-mentioned antifreezes, this invention does not have a special limitation on the ratio of different antifreezes, and any ratio is acceptable.

[0034] The fluopyram nano-suspension provided by the present invention comprises 0.01-0.5% preservative, preferably 0.05-0.3%, and more preferably 0.1-0.2% by mass percentage.

[0035] In this invention, the preservative preferably includes at least one of sodium benzoate and Kathon, more preferably Kathon. When the preservative is either of the above two, this invention does not have a special limitation on the ratio of different preservatives, and any ratio is acceptable.

[0036] The fluopyram nano-suspension provided by the present invention comprises 0.1-2% defoamer, preferably 0.3-1.5%, and more preferably 0.5-1.0% by mass percentage.

[0037] In this invention, the defoamer is preferably an organosilicon defoamer.

[0038] In this invention, the silicone-based defoamer is preferably at least one of X-7550 or MOMENTIVE SAG 1572, more preferably X-7550. When the defoamer is either of the above two, this invention does not have a special limitation on the ratio of different defoamers, and any ratio is acceptable.

[0039] The fluopyram nano-suspension provided by this invention comprises the remainder water, by weight percentage.

[0040] This invention provides a method for preparing the fluopyram nano-suspension described in the above technical solution, comprising the following steps: Dispersant, wetting agent, antifreeze, and part of defoamer are mixed with water to obtain the first mixture; Azoxystrobin and flutriafol were mixed with the first mixture and homogenized to obtain the second mixture. After coarse grinding of the second mixture, it is subjected to staged cyclic grinding until the material particle size D is reached. 90 ≤500nm, to obtain the third mixture; The third mixture is mixed with thickener, preservative and remaining defoamer, and homogenized for the second time to obtain fluopyram nano-suspension.

[0041] In this invention, the mass of the defoamer is preferably 60% of the total amount of defoamer; when preparing the third mixture, 20-40% of the total amount of defoamer is added, more preferably 20-30%, so that there are no obvious bubbles on the surface of the preparation, and the amount of the remaining defoamer is determined accordingly.

[0042] The present invention does not have any special limitations on the specific parameters of the first homogenization and the second homogenization; the materials can be mixed evenly by following a process known in the art.

[0043] This invention does not impose specific limitations on the parameters of the coarse grinding and graded cyclic grinding; the desired particle size can be achieved by following a process well-known in the art. In an embodiment of this invention, a colloid mill is specifically used for coarse grinding to a particle size D. 98 <50μm, then graded cyclic grinding is performed using grinding beads with a particle size of 0.8~1.0mm, grinding until the particle size D of the material in the mixture is reduced. 98 For particles with a diameter of 8~10μm, add an appropriate amount of defoamer until no obvious bubbles are visible, then replace with grinding beads with a particle size of 0.1mm±0.03mm for continuous grinding until the particle size D of the material in the second mixture is reached. 90 ≤500nm and D 98 ≤0.6μm, to obtain the third mixture.

[0044] This invention provides the application of the fluopyram nano-suspension agent described in the above-described technical solution or the fluopyram nano-suspension agent prepared by the above-described preparation method in the field of pesticides.

[0045] The specific embodiments of the present invention are described in detail below, but it should be understood that the scope of protection of the present invention is not limited to the specific embodiments. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without inventive effort are within the scope of protection of the present invention.

[0046] Unless otherwise specified, the experimental methods described in the various embodiments of this invention are conventional methods; unless otherwise specified, the reagents and raw materials described below are all commercially available.

[0047] Flutriafol technical grade: purchased from Adomai Huifeng (Jiangsu) Co., Ltd.; Azoxystrobin technical grade: purchased from Inner Mongolia Lingsheng Crop Technology Co., Ltd.; Dispersant CF-20S and wetting agent T80: purchased from Yuanqidian New Materials Technology (Shanghai) Co., Ltd.; Dispersant Dispersogen 1494 liq and wetting agent AGRIGEN B848: purchased from Shanghai Ruichuan International Trade Co., Ltd. Xanthan gum and silicone defoamer X-7550: purchased from Jinan Jinhe New Materials Co., Ltd. MOMENTIVE SAG 1572 silicone defoamer: purchased from Momentive Silicone Materials (Shanghai) Co., Ltd. Magnesium aluminum silicate: purchased from Suzhou Guojian Huitou Mineral New Materials Co., Ltd.; Ethylene glycol and sodium benzoate: purchased from Huai'an Haida Industry and Trade Co., Ltd.; propylene glycol: purchased from Zhengzhou Xinrui Fine Chemical Co., Ltd.; glycerol: purchased from Suzhou Fuzhiyuan Biotechnology Co., Ltd.; Kathon: purchased from Nanjing Gutian Chemical Co., Ltd. In the following examples, xanthan gum was prepared into xanthan gum colloids of different concentrations using deionized water.

[0048] Example 1

[0049] The flutriafol nano-suspension provided in this embodiment has the following components by mass percentage: flutriafol 15%, azoxystrobin 20%, dispersant CF-20S 6%, dispersant Dispersogen 1494 liq 3%, wetting agent AGRIGEN B848 1%, wetting agent T80 1%, thickener xanthan gum 0.2% (provided using 1wt% xanthan gum colloid, corresponding to a colloid mass percentage of 20%), thickener magnesium aluminum silicate 1%, antifreeze ethylene glycol 3%, preservative Kathon 0.2%, organosilicon defoamer X-7550 0.5%, and the balance being water.

[0050] The preparation method is as follows: Step S1: Mix all the dispersant, wetting agent, antifreeze, and 0.3wt% (according to the content in the formula) of defoamer with water to obtain the first mixture; Step S2: Mix flutriafol and azoxystrobin with the first mixture and homogenize for 30 min to obtain the second mixture; The second mixture was coarsely ground using a colloid mill until the material particle size D was reached. 98 <50μm, then graded cyclic grinding is performed using grinding beads with a particle size of 0.8~1.0mm, grinding until the particle size D of the material in the mixture is reduced. 98 For particles with a diameter of 8~10μm, add 0.1wt% (according to the content in the formula) of defoamer until no obvious bubbles are visible. Then, use grinding beads with a particle size of 0.1mm±0.03mm for cyclic grinding until the particle size D of the material in the second mixture is reached. 90 ≤500nm and D 98 ≤0.6μm, yielding the third mixture; Step S3: Mix the third mixture with the thickener, preservative and the remaining 0.1wt% organosilicon defoamer, and homogenize for 30 min to obtain the nano suspension.

[0051] Example 2

[0052] In this embodiment, the mass percentage of each component of the fluopyram nano-suspension is as follows: Flutriafol 5%, azoxystrobin 30%, CF-20S 6%, 1494 liq 2%, wetting agent AGRIGEN B848 2%, T80 1%, thickener xanthan gum 0.2% (provided using 1wt% xanthan gum colloid, corresponding to 20% of the colloid mass), magnesium aluminum silicate 1%, ethylene glycol 3%, preservative Kathon 0.2%, silicone defoamer X-7550 0.5%, balance water.

[0053] The preparation method is the same as in Example 1.

[0054] Example 3

[0055] In this embodiment, the mass percentage of each component of the fluopyram nano-suspension is as follows: Flutriafol 20%, azoxystrobin 15%, CF-20S 8%, 1494 liq 4%, AGRIGEN B848 2%, thickener xanthan gum 0.3% (provided using 1.5wt% xanthan gum colloid, corresponding to 20% of the colloid mass), glycerol 3%, Kathon 0.2%, silicone defoamer X-7550 0.5%, balance water.

[0056] The preparation method is the same as in Example 1.

[0057] Example 4

[0058] In this embodiment, the mass percentage of each component of the fluopyram nano-suspension is as follows: Flutriafol 10%, azoxystrobin 10%, CF-20S 4%, 1494 liq 2%, AGRIGEN B848 3%, T80 2%, thickener xanthan gum 0.2% (provided using 1wt% xanthan gum colloid, corresponding to 20% of the colloid mass), magnesium aluminum silicate 1%, ethylene glycol 3%, Kathon 0.2%, organosilicon defoamer X-7550 0.5%, balance water.

[0059] The preparation method is the same as in Example 1.

[0060] Example 5

[0061] In this embodiment, the mass percentage of each component of the fluopyram nano-suspension is as follows: Flutriafol 15%, azoxystrobin 20%, CF-20S 4%, 1494 liq 8%, T80 3%, thickener xanthan gum 0.25% (provided using 2wt% xanthan gum colloid, corresponding to a colloid mass percentage of 12.5%), magnesium aluminum silicate 1%, propylene glycol 3%, Kathon 0.2%, organosilicon defoamer X-7550 0.5%, balance water.

[0062] The preparation method is the same as in Example 1.

[0063] Example 6

[0064] In this embodiment, the mass percentage of each component of the fluopyram nano-suspension is as follows: Flutriafol 15%, azoxystrobin 20%, CF-20S 6%, 1494 liq 4%, AGRIGEN B848 3%, thickener xanthan gum 0.2% (provided using 1wt% xanthan gum colloid, corresponding to 20% of the colloid mass), magnesium aluminum silicate 1%, glycerol 3%, sodium benzoate 0.2%, organosilicon defoamer X-7550 0.5%, balance water.

[0065] The preparation method is the same as in Example 1.

[0066] Example 7

[0067] In this embodiment, the mass percentage of each component of the fluopyram nano-suspension is as follows: Flutriafol 5%, azoxystrobin 15%, CF-20S 3%, 1494 liq 9%, AGRIGEN B848 2%, thickener xanthan gum 0.25% (provided using 2wt% xanthan gum colloid, corresponding to a colloid mass percentage of 12.5%), magnesium aluminum silicate 1%, glycerol 3%, Kathon 0.2%, organosilicon defoamer X-7550 0.5%, balance water.

[0068] The preparation method is the same as in Example 1.

[0069] Example 8

[0070] In this embodiment, the mass percentage of each component of the fluopyram nano-suspension is as follows: Flutriafol 20%, azoxystrobin 20%, CF-20S 8%, 1494 liq 4%, T80 2%, thickener xanthan gum 0.2% (provided using 1wt% xanthan gum colloid, corresponding to 20% of the colloid mass), magnesium aluminum silicate 1%, ethylene glycol 3%, Kathon 0.2%, silicone defoamer MOMENTIVE SAG 1572 0.5%, balance water.

[0071] The preparation method is the same as in Example 1.

[0072] Example 9

[0073] In this embodiment, the mass percentage of each component of the fluopyram nano-suspension is as follows: Flutriafol 5%, azoxystrobin 25%, CF-20S 6%, 1494 liq 4%, T80 2%, thickener xanthan gum 0.1% (provided using 1wt% xanthan gum colloid, corresponding to 10% of the colloid mass), magnesium aluminum silicate 1.5%, ethylene glycol 3%, Kathon 0.2%, silicone defoamer MOMENTIVE SAG 1572 0.5%, balance water.

[0074] The preparation method is the same as in Example 1.

[0075] Comparative Example 1

[0076] The only difference from Example 1 is that 6% 1494 liq is used instead of 6% CF-20S, that is, only 1494 liq is used as a dispersant.

[0077] Structural and performance testing

[0078] 1) Particle size analysis

[0079] The particle size stability of the fluopyram nano-suspension concentrates in Examples 1-9 and Comparative Example 1 was tested. Specifically, the particle size stability was measured before heat storage (i.e., day 0). 98 Particle size, D after 14 days of thermal storage 98 Particle size, thermal storage for 14 days, then transferred to room temperature for 1 month D 98 Particle size (with the thermal storage temperature set at 54℃), and D after being diluted 40 times and 80 times with water and left to stand for 1 hour and 12 hours respectively (simulating two common working conditions in aerial spraying operations, namely, applying the pesticide within 1 hour of dilution on the same day and applying the pesticide the day after dilution more than 12 hours in advance), and then shaken well. 98 Particle size was measured, and the changes in the values ​​before and after were observed. The particle size distribution was tested using a particle size analyzer, and the test results are shown in Table 1.

[0080] Table 1. Particle size analysis of nano-suspension agents in Examples 1-9 and Comparative Example 1

[0081] As shown in Table 1, the particle size changes before and after heat storage in Examples 1-9 were minimal, and Comparative Example 1 also remained relatively stable. This is because, in the undiluted state, the system viscosity, additive system, and dosage were all suitable, which suppressed the thermal motion and Austronesian ripening effect of the active pharmaceutical ingredient particles. Meanwhile, Comparative Example 1 showed a larger particle size increase during heat storage compared to Example 1, indicating that the synergistic application of additive CF-20S and 1494 liq is superior to using 1494 liq alone in terms of heat storage stability. Under low dilution conditions (40x and 80x dilution), Examples 4, 5, and 7, due to their lower CF-20S dosage, still showed some particle size increase after 12 hours, but remained at the nanometer level, while Comparative Example 1 showed a significant increase to the micrometer level, comparable to conventional suspension formulations.

[0082] 2) Field bioactivity test

[0083] The sources of the pesticides supplied are: fluopyram nano-suspension (fluopyram-pyraclostrobin 35%) prepared according to Example 1 of the present invention, fluopyram nano-suspension prepared according to Comparative Example 1 of the present invention, and commercially available 35% fluopyram aqueous suspension purchased from Jiangsu Jiangu Chemical Co., Ltd.

[0084] The application method was aerial spraying. Before application, the pesticide was diluted according to the dosage and left to stand for 1 hour, or diluted and left to stand for 12 hours, and then simply stirred to disperse. The comparison of the effects of various pesticides and treatments on the control of rice blast is shown in Table 2.

[0085] Table 2. Effects of pesticides applied by aerial spraying in the field on rice blast control.

[0086] As shown in Tables 1 and 2, under the same dilution ratio, the control efficacy against rice blast decreases with the increase of the particle size of the active ingredient in the diluted solution of Example 1 or Comparative Example 1. This is especially true for Comparative Example 1, which, after standing for 12 hours at an 80-fold dilution, exhibits a significantly lower Dg. 98 It is already close to that of conventional suspension concentrates, and its efficacy is also similar to that of commercially available 35% fluopyram suspension concentrate, indicating that the formed microparticle clusters are irreversible; while in Example 1, the particle size remained basically unchanged after dilution, and its efficacy was also basically the same, which is better than Comparative Example 1 and commercially available 35% fluopyram suspension concentrate.

[0087] As can be seen from the control effect, the 35% fluopyram nano-aqueous suspension in Example 1 of this invention is significantly better than the commercially available 35% fluopyram suspension (non-nano-suspension) in terms of both speed of action and control effect, under the same dosage of active ingredient.

[0088] The above description is only a preferred embodiment of the present invention. It should be noted that for those skilled in the art, several improvements and modifications can be made without departing from the principle of the present invention, and these improvements and modifications should also be considered within the scope of protection of the present invention.

Claims

1. A fluopyram nano-suspension agent, characterized in that, It includes the following components by mass percentage: Flutriafol 5-20%, azoxystrobin 10-30%, wetting agent 2-5%, dispersant 6-12%, thickener 0.2-2%, antifreeze 1-5%, preservative 0.01-0.5%, defoamer 0.1-2%, balance water; The dispersant comprises alkylphenol polyoxyethylene ether formaldehyde condensate sulfonate and block polyether phosphate.

2. The fluopyram nano-suspension agent according to claim 1, characterized in that, The alkylphenol polyoxyethylene ether formaldehyde condensate sulfonate is Dispersogen 1494 liq; the block polyether phosphate is CF-20S; the mass ratio of Dispersogen 1494 liq to CF-20S is 1:3 to 3:

1.

3. The fluopyram nano-suspension agent according to claim 1, characterized in that, The wetting agent includes one or both of block polyethers and C8-C14 fatty alcohol ethoxypropoxylates.

4. The fluopyram nano-suspension agent according to claim 3, characterized in that, The block polyether is AGRIGEN B848; the C8-C14 fatty alcohol ethoxypropoxylate is T80.

5. The fluopyram nano-suspension agent according to claim 1, characterized in that, The thickener includes one or both of magnesium aluminum silicate and xanthan gum.

6. The fluopyram nano-suspension agent according to claim 1, characterized in that, The antifreeze includes at least one of ethylene glycol, glycerol, and propylene glycol.

7. The fluopyram nano-suspension agent according to claim 1, characterized in that, The preservative includes at least one of sodium benzoate and Kathon.

8. The fluopyram nano-suspension agent according to claim 1, characterized in that, The defoamer is an organosilicon defoamer.

9. The method for preparing the fluopyram nano-suspension agent according to any one of claims 1 to 8, characterized in that, Includes the following steps: Dispersant, wetting agent, antifreeze, and part of defoamer are mixed with water to obtain the first mixture; Azoxystrobin and flutriafol were mixed with the first mixture and homogenized to obtain the second mixture. After coarse grinding of the second mixture, it is subjected to staged cyclic grinding until the material particle size D is reached. 90 ≤500nm, to obtain the third mixture; The third mixture is mixed with thickener, preservative and remaining defoamer, and homogenized for the second time to obtain fluopyram nano-suspension.

10. The application of the fluopyram nano-suspension agent according to any one of claims 1 to 8 or the fluopyram nano-suspension agent prepared by the preparation method according to claim 9 in the field of pesticides.

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