Rosa roxburghii tratt fruit and ganoderma lucidum soft capsule for enhancing immunity and preparation method thereof
By optimizing the preparation process and dosage form design of prickly pear and Ganoderma lucidum, the problems of active ingredient loss and poor stability in existing products have been solved, achieving efficient immunomodulatory effects and stability, making prickly pear and Ganoderma lucidum soft capsules suitable for industrial production.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- GUIZHOU HUIHE PRICKLY PEAR BIOTECHNOLOGY CO LTD
- Filing Date
- 2026-02-12
- Publication Date
- 2026-05-12
AI Technical Summary
Existing immune-regulating health foods suffer from insufficient retention of active ingredients, poor synergistic effects, and low stability. In particular, the raw material processing technology of prickly pear and Ganoderma lucidum fails to effectively protect their active ingredients, and the dosage form design is unreasonable, which affects the efficacy and stability of the products.
Prickly pear juice concentrate is prepared by fermentation with Lactobacillus brucellosis and low-temperature process, and combined with high-standard Ganoderma lucidum extract in a precise ratio of 1:(0.9-1.1). Camellia seed oil and beeswax are used as excipients. Through precise grinding with colloid mill, temperature difference controlled pelleting and segmented gradient drying, the stability and uniformity of active ingredients are ensured.
It significantly enhances the immune-regulating effect of prickly pear and Ganoderma lucidum soft capsules, improves the retention rate of active ingredients, and enhances the stability and taste of the product, making it suitable for industrial production and convenient to take.
Smart Images
Figure CN122004457A_ABST
Abstract
Description
Technical Field
[0001] This invention relates to the field of health food technology, specifically to a prickly pear and Ganoderma lucidum soft capsule that enhances immunity and its preparation method. Background Technology
[0002] With the fast pace of modern life and increasing work pressure, the number of people in a sub-healthy state continues to expand, and problems such as weakened immunity and fatigue are becoming increasingly common. People are increasingly eager for natural, safe, and effective immune-regulating health foods. As traditional medicinal and edible ingredients, prickly pear and Ganoderma lucidum have gained widespread attention in the health food industry due to their unique nutritional and efficacy advantages. Prickly pear is rich in natural vitamin C, polyphenols, and other antioxidants, which can effectively eliminate free radicals and reduce oxidative damage, providing a foundation for immune regulation. Ganoderma lucidum contains active ingredients such as polysaccharides and triterpenoids, which can activate immune cell activity and enhance the body's immune function. The two have a natural synergistic and complementary effect, providing a good foundation for developing compound immune-regulating health foods.
[0003] However, existing technologies for raw materials like prickly pear often employ conventional concentration and drying processes without specialized fermentation and low-temperature protection techniques. This results in easily oxidized components such as vitamin C and polyphenols being readily degraded by light, heat, and oxygen, leading to significant loss of active ingredients. Meanwhile, the preparation process for Ganoderma lucidum extract is rudimentary, with some products failing to strictly control the content of Ganoderma lucidum polysaccharides and triterpenoids, making it difficult to achieve effective concentrations. Furthermore, the two raw materials are often simply mixed without a scientifically balanced formulation, failing to fully leverage their synergistic effects in antioxidation and immune regulation, resulting in unstable product efficacy and poor results.
[0004] Furthermore, existing technologies do not employ precise grinding and homogenization processes, resulting in excessively large and uneven particle sizes of the contents. This not only affects the body's absorption efficiency but also easily leads to stratification of the capsule contents. During the pelleting process, the temperature difference between the contents and the capsule shell liquid is not controlled, and the thickness of the capsule shell is not precisely controlled, which can easily lead to problems such as capsule leakage and breakage. The drying process mostly uses single-temperature drying without gradient shaping drying, resulting in easy cracking of the capsule shell, uneven moisture distribution, poor capsule morphological stability, and easy deterioration during storage. In addition, the parameters of each process step lack clear standards, resulting in poor repeatability and making it difficult to ensure the uniformity between product batches.
[0005] Meanwhile, most existing related products are in powder, decoction, or hard capsule form. Powder is prone to absorbing moisture and is not easy to carry. Decoction is complicated to prepare and has a short shelf life. Hard capsules cannot mask the unpleasant flavors of prickly pear and Ganoderma lucidum and have a poor taste. Some capsules have unreasonable specifications, are inconvenient to swallow, and have unclear recommended dosages, resulting in low consumer compliance. Summary of the Invention
[0006] The purpose of this invention is to provide a prickly pear and Ganoderma lucidum soft capsule that enhances immunity and its preparation method, so as to solve the problems of insufficient retention of active ingredients, poor synergistic effects and low stability in existing immune-regulating health foods.
[0007] To achieve the above objectives, the present invention provides the following technical solution:
[0008] According to a first aspect of this disclosure, a prickly pear and Ganoderma lucidum soft capsule for enhancing immunity is provided, comprising contents and a capsule shell encapsulating the contents;
[0009] The contents, by weight, include the following components: 55-65 parts of prickly pear juice concentrate powder, 55-65 parts of Ganoderma lucidum extract, 350-380 parts of camellia seed oil, and 12-18 parts of beeswax.
[0010] The capsule shell comprises, by weight, the following components: 115-125 parts gelatin, 115-125 parts purified water, 2.5-3.5 parts caramel color, 0.2-0.4 parts titanium dioxide, and 0.015-0.025 parts brown iron oxide.
[0011] The prickly pear juice concentrate is prepared by fermentation with Lactobacillus brucellosis and low-temperature process, and the Ganoderma lucidum extract contains ≥20% Ganoderma lucidum polysaccharide and ≥5% triterpenoids.
[0012] Furthermore, the weight ratio of prickly pear juice concentrate to Ganoderma lucidum extract in the contents is 1:(0.9-1.1).
[0013] Furthermore, the acid value of the camellia seed oil is ≤1.0mg / g, and the melting point of the beeswax is 62-67℃.
[0014] Furthermore, the contents are a uniform suspension with a particle size in the range of 10-20 μm.
[0015] According to the second aspect of this disclosure, a method for preparing a prickly pear and Ganoderma lucidum soft capsule to enhance immunity is also provided, which is applied to the prickly pear and Ganoderma lucidum soft capsule of the first aspect, comprising the following steps:
[0016] S1. Heat the camellia seed oil to 60±5℃, add beeswax and stir until completely melted to obtain an oil phase matrix; add prickly pear juice concentrate and Ganoderma lucidum extract to the oil phase matrix, stir and mix, then grind and homogenize to obtain a uniform mixture of contents, and keep warm at 50±5℃.
[0017] S2. Dissolve gelatin and purified water at 70±5℃, add caramel color, titanium dioxide and brown iron oxide, stir evenly, degas under vacuum to obtain capsule shell solution, and keep warm at 60±5℃.
[0018] S3. The insulated contents mixture and the capsule shell liquid are compressed into capsules using a soft capsule compression machine. During the compression process, the temperature of the contents mixture is controlled at 50±5℃, the temperature of the capsule shell liquid is controlled at 60±5℃, and the temperature difference between the two is 5-10℃.
[0019] S4. Dry the soft capsules after they have been compressed into pellets until the moisture content of the capsule shell is ≤12%, and the prickly pear and Ganoderma lucidum soft capsules are obtained.
[0020] Furthermore, in step S1, the grinding and homogenization is carried out by grinding 2-3 times at 50-60°C using a colloid mill.
[0021] Furthermore, in step S2, the vacuum conditions are a vacuum degree of 0.06-0.08 MPa, a degassing temperature of 65±5℃, and a degassing time of 15-20 minutes.
[0022] Furthermore, in step S2, during the preparation of the capsule shell adhesive solution, the stirring time after adding caramel color, titanium dioxide and brown iron oxide is 20 minutes, and the stirring speed is 200 r / min.
[0023] Furthermore, in step S3, the thickness of the capsule shell is controlled to be 0.18-0.22 mm during the shot forming process.
[0024] Further, in step S4, the segmented gradient drying includes:
[0025] The first stage of drying involves a temperature of 25±5℃, a relative humidity of ≤60%, and a drying time of 2-3 hours.
[0026] The second stage of drying involves a temperature of 35±5℃, a relative humidity of ≤50%, and a drying time of 4-6 hours.
[0027] The third stage of drying involves a temperature of 25±5℃, a relative humidity of ≤60%, and a drying time of 1-2 hours.
[0028] Compared with existing technologies, this invention provides an immune-enhancing prickly pear and Ganoderma lucidum soft capsule and its preparation method. It utilizes a patented low-temperature process and Lactobacillus brucellosis fermentation to prepare prickly pear juice concentrate powder, which is then combined with high-quality Ganoderma lucidum extract in a precise 1:(0.9-1.1) ratio to form a core efficacy combination. The excipient system is optimized with camellia seed oil and beeswax. Simultaneously, it employs precise grinding with a colloid mill, temperature-controlled pelleting, and segmented gradient drying processes to standardize key parameters. This achieves synergistic effects between prickly pear and Ganoderma lucidum components, significantly enhancing immunity and relieving fatigue. It effectively protects easily oxidized active ingredients, improves product stability, and accelerates the retention rate of efficacy components to ≥90% after 6 months of testing. The soft capsule dosage form masks unpleasant flavors and is convenient to take. The formula and process are precise, controllable, and highly reproducible, suitable for large-scale industrial production. Furthermore, the raw materials are safe and have no adverse reactions, making it both practical and economical. Attached Figure Description
[0029] To more clearly illustrate the technical solutions in the embodiments of this application or the prior art, the drawings used in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments recorded in this invention. For those skilled in the art, other drawings can be obtained based on these drawings.
[0030] Figure 1 The flowchart illustrates the preparation method of the prickly pear and Ganoderma lucidum soft capsules provided in this embodiment of the invention. Detailed Implementation
[0031] To enable those skilled in the art to better understand the technical solution of the present invention, the present invention will be further described in detail below with reference to the accompanying drawings. It should be noted that the raw materials used in the following embodiments are all commercially available conventional raw materials. The prickly pear juice concentrate is prepared using *Lactobacillus brucellosis* fermentation and a low-temperature process, produced using the patented technology with patent number ZL202410372284.0. The *Ganoderma lucidum* extract is prepared using a water extraction and alcohol precipitation method (*Ganoderma lucidum* polysaccharide content ≥20%, triterpenoid content ≥5%). The camellia seed oil meets the GB 2716-2018 standard (acid value ≤1.0mg / g). The beeswax melting point is 62-67℃, and the gel strength is ≥220 Bloom. All raw materials meet the corresponding quality standards.
[0032] Example 1:
[0033] 1. Component dosage (parts by weight)
[0034] Contents: 55 parts prickly pear juice concentrate powder, 55 parts Ganoderma lucidum extract, 350 parts camellia seed oil, 12 parts beeswax;
[0035] Capsule shell: 115 parts gelatin, 115 parts purified water, 2.5 parts caramel color, 0.2 parts titanium dioxide, 0.015 parts brown iron oxide;
[0036] 2. Preparation process
[0037] S1. Heat 350 parts of camellia seed oil to 55°C, add 12 parts of beeswax and stir until completely melted to obtain an oil phase matrix; pulverize 55 parts of prickly pear juice concentrate powder and 55 parts of Ganoderma lucidum extract, pass through an 80-mesh sieve, slowly add to the oil phase matrix, stir at 400 r / min until no lumps are formed, grind twice at 50°C using a colloid mill to obtain a mixture of contents with a particle size of 18-20 μm, and keep warm at 45°C for later use.
[0038] S2. Dissolve 115 parts gelatin and 115 parts purified water by heating to 65°C. Add 2.5 parts caramel color, 0.2 parts titanium dioxide, and 0.015 parts brown iron oxide. Stir at 200 r / min for 20 minutes. Degas at 0.06 MPa and 60°C for 20 minutes to obtain the capsule shell solution. Keep warm at 55°C for later use.
[0039] S3. A rotary soft capsule compression machine is used to control the temperature of the contents at 45℃, the temperature of the capsule shell liquid at 55℃ (temperature difference 10℃), the thickness of the capsule shell at 0.18mm, and the rotation speed at 20r / min for capsule compression.
[0040] S4. Segmented gradient drying: First stage: 20℃, 55% humidity, drying for 3 hours; Second stage: 30℃, 45% humidity, drying for 6 hours; Third stage: 20℃, 55% humidity, drying for 2 hours, drying until the shell moisture content is 11.5%; After cleaning, polishing and screening, the finished product is obtained.
[0041] Example 2:
[0042] 1. Component dosage (parts by weight)
[0043] Contents: 60 parts prickly pear juice concentrate powder, 60 parts Ganoderma lucidum extract, 365 parts camellia seed oil, 15 parts beeswax;
[0044] Capsule shell: 120 parts gelatin, 120 parts purified water, 3 parts caramel color, 0.3 parts titanium dioxide, and 0.02 parts brown iron oxide.
[0045] 2. Preparation process
[0046] S1. Heat 365 parts of camellia seed oil to 60℃, add 15 parts of beeswax and stir until completely melted to obtain an oil phase matrix; pulverize 60 parts of prickly pear juice concentrate powder and 60 parts of Ganoderma lucidum extract, pass them through an 80-mesh sieve, and slowly add them to the oil phase matrix. First, stir at 400 r / min until initially dispersed, then increase the speed to 500 r / min and stir for 30 minutes. Grind three times at 55℃ using a colloid mill to obtain a mixture of contents with a particle size of 12-15 μm, and keep it at 50℃ for later use.
[0047] S2. Dissolve 120 parts gelatin and 120 parts purified water by heating to 70°C. Add 3 parts caramel color, 0.3 parts titanium dioxide, and 0.02 parts brown iron oxide. Stir at 200 r / min for 20 minutes. Degas at 0.07 MPa and 65°C for 18 minutes to obtain the capsule shell solution. Keep warm at 60°C for later use.
[0048] S3. A rotary soft capsule compression machine is used to control the temperature of the contents at 50℃, the temperature of the capsule shell liquid at 60℃ (temperature difference 10℃), the thickness of the capsule shell at 0.20mm, and the rotation speed at 25r / min for capsule compression.
[0049] S4. Segmented gradient drying: First stage: 25℃, 60% humidity, drying for 2.5h; Second stage: 35℃, 50% humidity, drying for 5h; Third stage: 25℃, 60% humidity, drying for 1.5h, drying until the moisture content of the capsule shell is 10.5%; After cleaning, polishing and screening, the finished product is obtained.
[0050] Example 3:
[0051] 1. Component dosage (parts by weight)
[0052] Contents: 65 parts prickly pear juice concentrate powder, 65 parts Ganoderma lucidum extract, 380 parts camellia seed oil, 18 parts beeswax;
[0053] Capsule shell: 125 parts gelatin, 125 parts purified water, 3.5 parts caramel color, 0.4 parts titanium dioxide, and 0.025 parts brown iron oxide.
[0054] 2. Preparation process
[0055] S1. Heat 380 parts of camellia seed oil to 65°C, add 18 parts of beeswax and stir until completely melted to obtain an oil phase matrix; pulverize 65 parts of prickly pear juice concentrate powder and 65 parts of Ganoderma lucidum extract, pass through an 80-mesh sieve, and slowly add them to the oil phase matrix. Stir at 500 r / min until there are no lumps, and grind three times at 60°C using a colloid mill to obtain a mixture of contents with a particle size of 10-12 μm. Keep it warm at 55°C for later use.
[0056] S2. Dissolve 125 parts gelatin and 125 parts purified water by heating to 75°C. Add 3.5 parts caramel color, 0.4 parts titanium dioxide, and 0.025 parts brown iron oxide. Stir at 200 r / min for 20 minutes. Degas at 70°C under a vacuum of 0.08 MPa for 15 minutes to obtain the capsule shell solution. Keep warm at 65°C for later use.
[0057] S3. A rotary soft capsule compression machine is used to control the temperature of the contents at 55℃, the temperature of the capsule shell liquid at 65℃ (temperature difference 10℃), the thickness of the capsule shell at 0.22mm, and the rotation speed at 30r / min for capsule compression.
[0058] S4. Segmented gradient drying: First stage: 30℃, 60% humidity, drying for 2 hours; Second stage: 40℃, 50% humidity, drying for 4 hours; Third stage: 30℃, 60% humidity, drying for 1 hour, drying until the moisture content of the capsule shell is 11.0%; After cleaning, polishing and screening, the finished product is obtained.
[0059] Comparative Example
[0060] Comparative Example 1: Deviated from the core component ratio (45 parts of prickly pear juice concentrate powder, 75 parts of Ganoderma lucidum extract, and the remaining components and processes are the same as in Example 2).
[0061] Comparative Example 2: Deviated from the core component ratio (60 parts of prickly pear juice concentrate powder, 45 parts of Ganoderma lucidum extract, and the remaining components and processes are the same as in Example 2).
[0062] Comparative Example 3: The contents were not ground and homogenized (the other components and processes were the same as in Example 2);
[0063] Comparative Example 4: The drying process was changed to single temperature drying (35°C, 50% humidity, drying for 8 hours, with the remaining components and processes the same as in Example 2).
[0064] Testing and Experiment
[0065] The prickly pear and Ganoderma lucidum soft capsules prepared in the above three sets of examples and four sets of comparative examples were subjected to unified testing. The testing items included sensory indicators, physicochemical indicators, efficacy indicators, and stability indicators. The testing methods are as follows:
[0066] 1. Sensory indicators: visually observe the appearance and color, smell the odor, and observe the state of the contents;
[0067] 2. Physicochemical properties: particle size of contents (detected by laser particle size analyzer), moisture content of capsule shell (detected by drying method), disintegration time (detected according to the relevant methods of the Pharmacopoeia of the People's Republic of China), and single-particle weight error (weighed by electronic balance);
[0068] 3. Efficacy indicators: Vitamin C content per capsule (UV-Vis spectrophotometry), Ganoderma lucidum polysaccharide content per capsule (high performance liquid chromatography), thymus index in mice (animal experiment, mice were administered via gavage for 30 days, and the thymus index was measured), and weight-bearing swimming time in mice (animal experiment, mice were administered via gavage for 30 days, and the weight-bearing swimming time was measured).
[0069] 4. Stability indicators: Accelerated stability test (40℃, 75% relative humidity, sealed storage for 6 months) to test the retention rate of active ingredients (vitamin C retention rate, Ganoderma lucidum polysaccharide retention rate) and appearance after 6 months.
[0070] Test results
[0071] The test results for each embodiment and comparative example are shown in the table below:
[0072] Group Sensory indicators Contents particle size (μm) Moisture content of capsule shell (%) Disintegration timeout (min) Single grain weight error (%) Vitamin C content per capsule (mg) Ganoderma lucidum polysaccharide content per capsule (mg) Mouse thymus index (mg / g) Swimming time under load for mice (min) Vitamin C retention rate (%) after 6 months Retention rate of Ganoderma lucidum polysaccharides after 6 months (%) Appearance after 6 months Example 1 Brownish-brown color, smooth surface, homogeneous contents, and no odor. 18-20 11.5 28 ±4.8 5.0 3.0 38.2 125 90.5 93.2 The shape is intact, with no leakage or deformation. Example 2 Brownish-brown in color, with a smooth and plump surface, uniform and delicate contents, no off-odor, and a faint fruity aroma. 12-15 10.5 22 ±3.2 5.5 3.2 45.6 158 91.3 94.7 The shape is intact and full, with no leakage or deformation, and the color is uniform. Example 3 Brownish-brown color, smooth surface, homogeneous contents, and no odor. 10-12 11.0 25 ±4.5 5.4 3.1 42.3 146 90.8 93.8 The shape is intact, with no leakage or deformation. Comparative Example 1 Brownish-red in color, with a relatively smooth surface and slightly clumped contents. 16-19 11.8 32 ±5.2 4.2 3.3 32.5 108 85.7 90.2 Some capsules showed slight leakage and uneven color. Comparative Example 2 Brownish-brown color, relatively smooth surface, homogeneous contents 15-18 11.6 30 ±4.9 5.4 2.5 33.1 112 84.3 89.5 Some capsules were deformed, but there was no obvious leakage. Comparative Example 3 Brownish-red, with a rough surface and obvious clumps of contents. 35-45 12.2 38 ±6.1 4.8 2.8 29.8 95 78.5 86.3 Most capsules leaked, deformed, and had their contents separated. Comparative Example 4 Brownish-brown color, with cracked surface, and homogeneous contents. 12-15 11.7 35 ±4.7 5.3 3.1 36.7 120 82.1 88.7 Most capsules had cracked surfaces and some were leaking.
[0073] (Note: The thymus index and weighted swimming time of mice are average values; the allowable error range for single-particle weight is ±5%, the allowable disintegration time is ≤30min, and the retention rate of active ingredients after 6 months is preferably ≥90%).
[0074] Results Analysis
[0075] 1. Analysis of the Influence of Component Ratio: Examples 1-3 all fall within the weight range of the components claimed in this invention, and the ratio of prickly pear juice concentrate to Ganoderma lucidum extract is 1:(0.9-1.1). All their test indicators are superior to those of Comparative Examples 1-2 (which deviate from this ratio range). Specifically, in Comparative Example 1, the excessive Ganoderma lucidum extract and insufficient prickly pear juice concentrate resulted in decreased vitamin C content, reduced antioxidant capacity, weakened synergistic effect, significantly reduced thymus index and weight-bearing swimming time in mice, and decreased stability. In Comparative Example 2, the excessive prickly pear juice concentrate and insufficient Ganoderma lucidum extract resulted in decreased Ganoderma lucidum polysaccharide content, weakened immunomodulatory effect, and similarly affected synergistic effect and stability. This demonstrates that the core component ratio range and the ratio of the two components defined in this invention are crucial to ensuring product efficacy and stability.
[0076] 2. Analysis of the Influence of Process Parameters: Examples 1-3 all adopted the preparation process (grinding and homogenization, segmented gradient drying) defined in this invention, with the particle size of the contents controlled at 10-20 μm, achieving acceptable disintegration time and good stability. However, Comparative Example 3, without grinding and homogenization, had excessively large particle size and significant agglomeration, leading to a prolonged disintegration time, poor absorption of active ingredients, and a significant decrease in stability (a substantial reduction in the retention rate of active ingredients after 6 months, with capsule leakage and deformation). Comparative Example 4 used a single-temperature drying method, resulting in surface cracking of the capsule shell, decreased stability, and a prolonged disintegration time. This demonstrates that the process parameters defined in this invention, such as grinding and homogenization and segmented gradient drying, are crucial for ensuring product morphology, stability, and efficacy.
[0077] 3. Determination of Optimal Formulation: Comparing the test results of Examples 1-3, Example 2 (a mixture of 60 parts prickly pear juice concentrate, 60 parts Ganoderma lucidum extract, 365 parts camellia seed oil, 15 parts beeswax, 120 parts gelatin, 120 parts purified water, 3 parts caramel color, 0.3 parts titanium dioxide, and 0.02 parts brown iron oxide, combined with optimal process parameters) exhibits the best overall performance: optimal sensory characteristics, uniform particle size (12-15 μm), lowest capsule moisture content (10.5%), shortest disintegration time (22 min), smallest single-particle weight error (±3.2%), highest content of active ingredients (5.5 mg Vitamin C and 3.2 mg Ganoderma lucidum polysaccharides per capsule), optimal immune regulation and anti-fatigue effects (45.6 mg / g thymus index in mice, 158 min of weight-bearing swimming time), and best stability (≥91% retention rate of active ingredients after 6 months, with intact and plump appearance). Therefore, the component ratio and process parameters of Example 2 represent the optimal implementation scheme of this invention.
[0078] in conclusion
[0079] This invention optimizes the ratio of core active ingredients, controlling the proportions of prickly pear juice concentrate and Ganoderma lucidum extract to 55-65 parts, with a ratio of 1:(0.9-1.1). Combined with suitable excipients and a precise preparation process, the resulting prickly pear and Ganoderma lucidum soft capsules fully leverage the synergistic effects of prickly pear and Ganoderma lucidum, exhibiting clear effects in enhancing immunity and relieving physical fatigue. The product has uniform contents, intact capsule shell morphology, high stability, and convenient administration, with all indicators meeting relevant health food standards. The preparation process is precise, controllable, and highly repeatable, suitable for large-scale industrial production, and has broad market application prospects.
[0080] The foregoing has only described certain exemplary embodiments of the present invention by way of illustration. Undoubtedly, those skilled in the art can modify the described embodiments in various ways without departing from the spirit and scope of the present invention. Therefore, the foregoing drawings and descriptions are illustrative in nature and should not be construed as limiting the scope of protection of the claims of the present invention.
Claims
1. A prickly pear and Ganoderma lucidum soft capsule for enhancing immunity, characterized in that, It consists of contents and a capsule that encloses the contents; The contents, by weight, include the following components: 55-65 parts of prickly pear juice concentrate powder, 55-65 parts of Ganoderma lucidum extract, 350-380 parts of camellia seed oil, and 12-18 parts of beeswax. The capsule shell comprises, by weight, the following components: 115-125 parts gelatin, 115-125 parts purified water, 2.5-3.5 parts caramel color, 0.2-0.4 parts titanium dioxide, and 0.015-0.025 parts brown iron oxide. The prickly pear juice concentrate is prepared by fermentation with Lactobacillus brucellosis and low-temperature process, and the Ganoderma lucidum extract contains ≥20% Ganoderma lucidum polysaccharide and ≥5% triterpenoids.
2. The immune-enhancing prickly pear and Ganoderma lucidum soft capsule according to claim 1, characterized in that, The weight ratio of prickly pear juice concentrate to Ganoderma lucidum extract in the contents is 1:(0.9-1.1).
3. The immune-enhancing prickly pear and Ganoderma lucidum soft capsule according to claim 1, characterized in that, The acid value of the camellia seed oil is ≤1.0mg / g, and the melting point of the beeswax is 62-67℃.
4. The immune-enhancing prickly pear and Ganoderma lucidum soft capsule according to claim 1, characterized in that, The contents are a uniform suspension with a particle size in the range of 10-20 μm.
5. A method for preparing a prickly pear and Ganoderma lucidum soft capsule to enhance immunity, characterized in that, The application in the prickly pear and Ganoderma lucidum soft capsules as described in any one of claims 1-4 includes the following steps: S1. Heat the camellia seed oil to 60±5℃, add beeswax and stir until completely melted to obtain an oil phase matrix; add prickly pear juice concentrate and Ganoderma lucidum extract to the oil phase matrix, stir and mix, then grind and homogenize to obtain a uniform mixture of contents, and keep warm at 50±5℃. S2. Dissolve gelatin and purified water at 70±5℃, add caramel color, titanium dioxide and brown iron oxide, stir evenly, degas under vacuum to obtain capsule shell solution, and keep warm at 60±5℃. S3. The insulated contents mixture and the capsule shell liquid are compressed into capsules using a soft capsule compression machine. During the compression process, the temperature of the contents mixture is controlled at 50±5℃, the temperature of the capsule shell liquid is controlled at 60±5℃, and the temperature difference between the two is 5-10℃. S4. Dry the soft capsules after they have been compressed into pellets until the moisture content of the capsule shell is ≤12%, and the prickly pear and Ganoderma lucidum soft capsules are obtained.
6. The method for preparing an immune-enhancing prickly pear and Ganoderma lucidum soft capsule according to claim 5, characterized in that, In step S1, the grinding and homogenization is carried out by grinding 2-3 times at 50-60℃ using a colloid mill.
7. The method for preparing an immune-enhancing prickly pear and Ganoderma lucidum soft capsule according to claim 5, characterized in that, In step S2, the vacuum conditions are a vacuum degree of 0.06-0.08 MPa, a degassing temperature of 65±5℃, and a degassing time of 15-20 minutes.
8. The method for preparing an immune-enhancing prickly pear and Ganoderma lucidum soft capsule according to claim 5, characterized in that, In step S2, during the preparation of the capsule shell adhesive solution, the stirring time after adding caramel color, titanium dioxide and brown iron oxide is 20 minutes, and the stirring speed is 200 r / min.
9. The method for preparing an immune-enhancing prickly pear and Ganoderma lucidum soft capsule according to claim 5, characterized in that, In step S3, the thickness of the capsule shell is controlled to be 0.18-0.22 mm during the shot pressing process.
10. The method for preparing an immune-enhancing prickly pear and Ganoderma lucidum soft capsule according to claim 5, characterized in that, In step S4, the segmented gradient drying includes: The first stage of drying involves a temperature of 25±5℃, a relative humidity of ≤60%, and a drying time of 2-3 hours. The second stage of drying involves a temperature of 35±5℃, a relative humidity of ≤50%, and a drying time of 4-6 hours. The third stage of drying involves a temperature of 25±5℃, a relative humidity of ≤60%, and a drying time of 1-2 hours.