Fine extraction liquid for activating hair follicles, preventing hair loss and nourishing hair

Abstract

The invention discloses essence liquid for activating hair follicles, preventing hair loss and nourishing hair, and relates to the technical field of hair care agents. The composition comprises the following components: an echinacea extract, a silybum marianum extract, a polygonum multiflorum extract, a pumpkin seed extract, ganoderan and a sea buckthorn fruit extract. The echinacea extract, the silybum marianum extract, the polygonum multiflorum extract, the pumpkin seed extract, the ganoderan and the sea buckthorn fruit extract are scientifically compounded, all the components have a synergistic effect, the technical effects of activating hair follicles, preventing hair loss and growing hair are jointly achieved, and the composition is natural in component, mild, free of irritation, good in safety and free of side effects. The shampoo is suitable for daily maintenance of various alopecia people.

Description

Technical Field

[0001] This invention relates to the field of hair care products technology, and to an essence that activates hair follicles, prevents hair loss, and promotes hair growth. Specifically, it relates to a composition, essence, and application of an essence that activates hair follicles, prevents hair loss, and promotes hair growth. Background Technology

[0002] From a pathological perspective, hair loss is not a single condition but the result of multiple intertwined factors, with abnormal hair follicle function being the core cause. Androgenetic alopecia, the most common type, accounts for over 90% of all hair loss cases. It is closely related to genetics; patients' hair follicles are abnormally sensitive to androgens, leading to gradual miniaturization and the degeneration of hair from coarse terminal hair to fine vellus hair. Alopecia areata is caused by immune system disorders, where T lymphocytes mistakenly attack hair follicles, causing inflammation and subsequently localized hair loss. Telogen effluvium is often induced by postpartum hormonal fluctuations, high stress levels, and rapid weight loss, manifesting as a significant increase in hair loss. Furthermore, imbalances in the scalp microenvironment, insufficient nutrient supply to hair follicles, dormancy of hair follicle stem cells, and apoptosis of dermal papilla cells can also lead to decreased hair follicle activity, ultimately causing hair loss or thinning. Research shows that hair follicle stem cells in bald scalps do not disappear; their metabolic mode is locked in a dormant state, unable to initiate growth. Effectively awakening dormant hair follicles and reversing follicle miniaturization has become the core breakthrough point for hair loss prevention and hair growth technology.

[0003] Currently, hair loss prevention and hair growth technologies are mainly divided into four major directions: chemical drug intervention, surgery, physical therapy, and the application of natural ingredients. However, each direction has significant limitations. In the field of chemical drugs, minoxidil and finasteride are the mainstream treatments. Minoxidil requires long-term or even lifelong use, and hair loss is prone to rapid rebound after discontinuation. It may also cause side effects such as scalp irritation and folliculitis. Solvents such as propylene glycol and ethanol commonly used in its formula can exacerbate damage to the scalp barrier. Finasteride is mainly for male androgenetic alopecia, and has side effects such as sexual dysfunction. It is completely contraindicated for women. Although surgical hair transplantation can quickly improve appearance, it has problems such as high cost, dependence on donor hair follicle resources, long postoperative recovery period, and potential scarring or infection risks. It also cannot solve the problem of continuous atrophy of the original hair follicles. Physical therapy, such as low-energy laser, has a relatively high safety profile, but its effect is weak when used alone. It is only effective for early-stage hair loss and needs to be used in conjunction with medication.

[0004] Natural hair loss prevention products have become a research hotspot in recent years due to their high safety profile, but they still have many technical shortcomings. For example, Chinese patent application CN118662418A discloses a natural plant extract composition for preventing and strengthening hair loss. Through the synergistic effect of seven plant extracts—including St. John's wort extract, Guaiac extract, Thunbergia odorifera peel extract, Mango leaf extract, Polygonum multiflorum extract, Platycladus orientalis leaf extract, and ginger extract—it effectively inhibits 5α-reductase, which causes seborrheic alopecia, and major microorganisms such as Malassezia furfur, Propionibacterium acnes, and Staphylococcus aureus, thereby reducing the probability of seborrheic alopecia. Chinese patent application CN101098677A discloses the use of plant extracts from Ajuga decumbens in the production of compositions for preventing or treating hair loss. Chinese patent application CN118477021A discloses a shampoo containing plant extracts for preventing hair loss and relieving itching, and a method for preparing the same. The shampoo comprises the following components: plant extracts, surfactants, moisturizers, conditioning agents, anti-dandruff and anti-itch agents, ammonium hydroxide, citric acid, preservatives, fragrance, and purified water as the remainder. The plant extracts are composed of ginseng root extract, alpinia serratifolia leaf extract, and cyperus succinate root oil in a mass ratio of 2-3:2-5:1. The conditioning agents include deacetylated chitosan, histidine, and amino-terminated polydimethylsiloxane. The anti-dandruff and anti-itch agent is piroctone ketone ethanolamine salt.

[0005] On the one hand, existing natural compositions often suffer from poor compatibility and insufficient synergistic effects of active ingredients. They tend to focus on the mechanism of action of a single component, failing to achieve synergistic regulation of the entire pathway from "hair follicle activation to inflammation suppression, microecological balance, and nutrient supply." Furthermore, some products claiming to be "natural and additive-free" still contain chemical excipients such as parabens, increasing the risk of allergies and reducing the product's naturalness. On the other hand, the extraction processes for natural active ingredients have shortcomings. Traditional high-temperature, high-pressure extraction methods, such as organic solvent reflux, lead to a significant loss of heat-sensitive active ingredients, are energy-intensive, and leave organic solvent residues, violating green production principles. In addition, the large molecular weight of natural active ingredients generally results in low transdermal absorption rates, with most components unable to penetrate the scalp barrier to reach the deep hair follicles. This leads to insufficient concentration of effective ingredients in the hair follicle microenvironment, failing to fully exert the effects of activating hair follicles and preventing hair loss and promoting hair growth.

[0006] In summary, existing hair loss prevention and hair growth technologies suffer from numerous drawbacks, including strong chemical dependence, significant side effects, insufficient naturalness, poor synergy of active ingredients, low transdermal absorption, unsatisfactory efficacy stability, and unreasonable preparation processes. They fail to activate dormant hair follicles at the root and reverse follicle miniaturization, making it difficult to meet consumer demand for safe, efficient, and long-lasting hair loss prevention and hair growth products, and also incompatible with the trend of green and environmentally friendly industry development. Therefore, developing a scientifically formulated composition and corresponding extract that effectively activates hair follicles, provides stable hair loss prevention and hair growth effects, and has a simple, environmentally friendly, and low-cost preparation process, along with its convenient and feasible preparation method and wide application, has become an urgent technical problem to be solved in the current field of hair loss prevention and hair growth. Summary of the Invention

[0007] To address the aforementioned problems, this invention provides an extract that activates hair follicles, prevents hair loss, and promotes hair growth. Specifically, it provides a composition, extract, and application for activating hair follicles, preventing hair loss, and promoting hair growth. The composition of this invention is made of natural ingredients, is mild and non-irritating, and has significant effects in activating hair follicles and preventing hair loss.

[0008] To achieve the above objectives, the technical solution adopted by the present invention is as follows:

[0009] On one hand, the present invention provides a composition for activating hair follicles, preventing hair loss and promoting hair growth, comprising the following components: echinacea extract, milk thistle extract, fleeceflower root extract, pumpkin seed extract, ganoderma lucidum polysaccharide and sea buckthorn fruit extract.

[0010] Preferably, the preparation method of the echinacea extract is as follows: after pulverizing echinacea, it is mixed with an ethanol aqueous solution, extracted in a gradient manner 1-3 times, the extracts are combined and concentrated to obtain the extract.

[0011] Preferably, the preparation method of the echinacea extract is as follows: after pulverizing echinacea, it is mixed with 30wt%-40wt% ethanol aqueous solution at a material-to-liquid ratio of 1g:10-18mL, and extracted once at 20-40℃ for 20-40min; then ethanol is added until the final solution concentration is 55wt%-65wt%, and extracted a second time at 55-65℃ for 20-40min; then ethanol is added until the final solution concentration is 70wt%-85wt%, and extracted a third time at 40-50℃ for 10-25min, the extracts are combined and concentrated to obtain the final product.

[0012] More preferably, the preparation method of the echinacea extract is as follows: the echinacea is washed, dried, pulverized and passed through an 80-mesh sieve, mixed with a 35wt% ethanol aqueous solution at a material-to-liquid ratio of 1g:15mL, and extracted once at 35℃ for 30min; then ethanol is added until the final solution concentration is 60wt%, and extracted a second time at 60℃ for 30min; then ethanol is added until the final solution concentration is 80wt%, and extracted a third time at 45℃ for 15min, the extracts are combined and concentrated to obtain the extract.

[0013] Preferably, the method for preparing the milk thistle extract is as follows: milk thistle fruit is crushed and mixed with water, and laccase, bromelain and pectin lyase are added for enzymatic hydrolysis to obtain the extract.

[0014] More preferably, the method for preparing the milk thistle extract is as follows: the milk thistle fruit is washed, dried, pulverized, and passed through a 40-mesh sieve. Then, it is mixed with water at a material-to-liquid ratio of 1g:12-18mL, the temperature is adjusted to 45-50℃, the pH is adjusted to 6.0-7.0, and laccase, bromelain, and pectin lyase are added at a mass ratio of 0.1-0.5:0.8-1.2:1.5-2.5 for 2-3 hours of enzymatic hydrolysis. The total mass of the laccase, bromelain, and pectin lyase is 0.1%-0.4% of the mass of the milk thistle fruit.

[0015] Preferably, the ingredients, by weight, include the following: 2-10 parts echinacea extract, 1-6 parts milk thistle extract, 10-20 parts Polygonum multiflorum extract, 2-10 parts pumpkin seed extract, 3-8 parts Ganoderma lucidum polysaccharide, and 8-15 parts sea buckthorn fruit extract.

[0016] More preferably, the ingredients, by weight, include the following: 6 parts echinacea extract, 4 parts milk thistle extract, 15 parts Polygonum multiflorum extract, 8 parts pumpkin seed extract, 5 parts Ganoderma lucidum polysaccharide and 12 parts sea buckthorn fruit extract.

[0017] Secondly, the present invention provides a method for preparing the above composition, comprising the following steps: mixing raw materials.

[0018] Thirdly, the present invention provides an essence for activating hair follicles, preventing hair loss and promoting hair growth, the raw materials of which include the above-mentioned composition and excipients acceptable in the cosmetics field.

[0019] Preferably, the mass of the composition is 2%-5% of the total mass of the raw materials.

[0020] Preferably, the excipients acceptable in the cosmetics field include solvents, hair conditioning agents, and cooling agents.

[0021] Preferably, the solvent is selected from at least one of 1,2-hexanediol, 1,3-propanediol, butanediol, glycerol, and water.

[0022] More preferably, the solvent is selected from 1,2-hexanediol and water.

[0023] Preferably, the mass ratio of 1,2-hexanediol to water is 1:20-40.

[0024] Preferably, the hair conditioning agent is selected from at least one of nicotinamide, panthenol, cyclodextrin, caffeine, and allantoin.

[0025] More preferably, the hair conditioning agent is nicotinamide, panthenol, cyclodextrin, caffeine, and allantoin.

[0026] Preferably, the cooling agent is menthol.

[0027] Fourthly, the present invention provides the application of the above-mentioned composition or essence in the preparation of products that activate hair follicles and prevent hair loss and promote hair growth.

[0028] Compared with the prior art, the present invention has the following beneficial effects: 1. This invention scientifically combines echinacea extract, milk thistle extract, fleeceflower root extract, pumpkin seed extract, Ganoderma lucidum polysaccharide, and sea buckthorn fruit extract. The components work synergistically to activate hair follicles and prevent hair loss and promote hair growth. Specifically, milk thistle extract and pumpkin seed extract work synergistically to effectively inhibit 5α-reductase activity, reduce the damage of dihydrotestosterone (DHT) to hair follicles, delay the miniaturization process of hair follicles, improve androgenetic alopecia from the root cause, and significantly reduce the amount of hair loss. Echinacea extract possesses excellent anti-inflammatory and scalp-regulating effects, reducing inflammation and infiltration around hair follicles, alleviating scalp redness, itching, and sensitivity, providing a stable and healthy scalp environment for hair growth, and reducing inflammation-mediated hair loss. Ganoderma lucidum polysaccharides significantly activate dermal papilla cells of hair follicles, upregulate hair follicle growth-related signals, awaken resting follicles, prolong the hair growth phase, promote the transformation of hair follicles from the resting phase to the growth phase, and increase the number of new hairs. Sea buckthorn fruit extract is rich in various vitamins, flavonoids, and polyphenols, possessing strong antioxidant capabilities. It can scavenge free radicals around hair follicles, reduce oxidative stress damage, delay hair follicle aging, and improve scalp microcirculation, enhancing nutrient supply to hair follicles. Through the combination and interaction of specific plant extracts, the effects of activating hair follicles and preventing hair loss and promoting hair growth are significantly enhanced.

[0029] 2. The composition of this invention uses natural plant extracts as active ingredients. It is scientifically formulated, mild in nature, and does not contain hormones, Western medicines, or strong irritants. It is friendly to the scalp barrier, has high tolerance for long-term use, and is safe. It is suitable for daily maintenance by people with various types of hair loss.

[0030] 3. The specific preparation method and formulation of this invention further enhance the effects of activating hair follicles, preventing hair loss and promoting hair growth. It has multiple synergistic effects through multiple pathways, including inhibiting DHT, anti-inflammatory repair, activating hair follicles, strengthening hair roots, anti-oxidation, and improving microcirculation. It has significant effects and is gentle and safe. Detailed Implementation

[0031] To make the technical means, creative features, achieved objectives, and effects of this invention readily understandable, the invention is further illustrated below with specific embodiments. However, these embodiments are merely preferred embodiments and not all embodiments. Other embodiments obtained by those skilled in the art based on the embodiments described herein without creative effort are all within the scope of protection of this invention. It is worth noting that the raw materials used in this invention are all common commercially available products, and their sources are not specifically limited. The technical and scientific terms used in the embodiments have the meanings commonly understood by those skilled in the art to which this invention pertains.

[0032] Polygonum multiflorum extract: purchased from Shaanxi Yuanbeibei Biotechnology Co., Ltd., product number YBB-CDF-9527; Pumpkin seed extract: purchased from Xi'an Xufeng Biotechnology Co., Ltd., brand name Tianfeng.

[0033] Ganoderma lucidum polysaccharides: 30% Ganoderma lucidum polysaccharides, purchased from Fufeng Sinote Biotechnology Co., Ltd., brand Sinote Biotechnology.

[0034] Sea buckthorn fruit extract: purchased from Baoji Liupanyun Biotechnology Co., Ltd., specification 10:1.

[0035] Example 1 A composition for activating hair follicles, preventing hair loss, and promoting hair growth, comprising, by weight, the following ingredients: 6 parts echinacea extract, 4 parts milk thistle extract, 15 parts Polygonum multiflorum extract, 8 parts pumpkin seed extract, 5 parts Ganoderma lucidum polysaccharide, and 12 parts sea buckthorn fruit extract. The above ingredients are mixed evenly to obtain the composition.

[0036] The preparation method of Echinacea extract is as follows: Echinacea is washed, dried, pulverized and passed through an 80-mesh sieve. It is mixed with 35wt% ethanol aqueous solution at a material-to-liquid ratio of 1g:15mL and extracted once at 35℃ for 30min. Then, ethanol is added until the final solution concentration is 60wt% and extracted a second time at 60℃ for 30min. Then, ethanol is added until the final solution concentration is 80wt% and extracted a third time at 45℃ for 15min. The extracts are combined and concentrated to obtain the final product.

[0037] The preparation method of milk thistle extract is as follows: milk thistle fruit is washed, dried, crushed, and passed through a 40-mesh sieve. Then it is mixed with water at a material-to-liquid ratio of 1g:16mL, the temperature is adjusted to 45℃ and the pH is 7.0, and laccase, bromelain and pectin lyase are added at a mass ratio of 0.3:1.0:2 for 2.5h enzymatic hydrolysis. The total mass of laccase, bromelain and pectin lyase is 0.3% of the mass of milk thistle fruit.

[0038] Example 2 A composition for activating hair follicles, preventing hair loss, and promoting hair growth, comprising, by weight, the following ingredients: 2 parts echinacea extract, 6 parts milk thistle extract, 10 parts Polygonum multiflorum extract, 10 parts pumpkin seed extract, 3 parts Ganoderma lucidum polysaccharide, and 15 parts sea buckthorn fruit extract. The above ingredients are mixed evenly to obtain the composition.

[0039] The preparation method of Echinacea extract is as follows: Echinacea is washed, dried, pulverized and passed through an 80-mesh sieve. It is mixed with 30wt% ethanol aqueous solution at a material-to-liquid ratio of 1g:10mL and extracted once at 40℃ for 20min. Then, ethanol is added until the final solution concentration is 65wt% and extracted a second time at 55℃ for 40min. Then, ethanol is added until the final solution concentration is 85wt% and extracted a third time at 50℃ for 25min. The extracts are combined and concentrated to obtain the final product.

[0040] The preparation method of milk thistle extract is as follows: milk thistle fruit is washed, dried, crushed, and passed through a 40-mesh sieve. Then it is mixed with water at a material-to-liquid ratio of 1g:12mL, the temperature is adjusted to 50℃ and the pH to 6.0, and laccase, bromelain and pectin lyase are added at a mass ratio of 0.1:1.2:1.5 for 2.0h of enzymatic hydrolysis. The total mass of laccase, bromelain and pectin lyase is 0.1% of the mass of milk thistle fruit.

[0041] Example 3 A composition for activating hair follicles, preventing hair loss, and promoting hair growth, comprising, by weight, the following ingredients: 10 parts echinacea extract, 1 part milk thistle extract, 20 parts Polygonum multiflorum extract, 2 parts pumpkin seed extract, 8 parts Ganoderma lucidum polysaccharide, and 8 parts sea buckthorn fruit extract. The above ingredients are mixed evenly to obtain the composition.

[0042] The preparation method of Echinacea extract is as follows: Echinacea is washed, dried, pulverized and passed through an 80-mesh sieve. It is mixed with 40wt% ethanol aqueous solution at a material-to-liquid ratio of 1g:18mL and extracted once at 20℃ for 40min. Then, ethanol is added until the final solution concentration is 55wt% and extracted a second time at 65℃ for 20min. Then, ethanol is added until the final solution concentration is 70wt% and extracted a third time at 40℃ for 10min. The extracts are combined and concentrated to obtain the final product.

[0043] The preparation method of milk thistle extract is as follows: milk thistle fruit is washed, dried, crushed, and passed through a 40-mesh sieve. Then it is mixed with water at a material-to-liquid ratio of 1g:18mL, the temperature is adjusted to 48℃ and the pH to 6.8, and laccase, bromelain and pectin lyase are added at a mass ratio of 0.5:0.8:2.5 for 3 hours of enzymatic hydrolysis. The total mass of laccase, bromelain and pectin lyase is 0.4% of the mass of milk thistle fruit.

[0044] Example 4 A hair follicle-activating, hair loss-preventing, and hair-growth-promoting essence, the raw materials and dosages of which are shown in Table 1 below: Table 1

[0045] The preparation method is as follows: (1) Mix 1,2-hexanediol and water in proportion and stir until homogeneous, and use as a solvent for later use.

[0046] (2) Add nicotinamide, panthenol and allantoin to 1 / 2 of the solvent in sequence, and stir until completely dissolved to obtain mixture 1.

[0047] (3) After mixing mixture 1 with cyclodextrin, menthol is slowly added to utilize the cavity structure of cyclodextrin for inclusion, thereby improving its water solubility and stability and reducing irritation; stirring is continued for 30 minutes to ensure full inclusion; then caffeine is added and stirring is continued until clear to obtain mixture 2; (4) Mix the active component with the remaining solvent and stir thoroughly; then add mixture 2 and stir evenly. Use a 0.22μm hydrophilic filter membrane for filtration and sterilization. Fill into a light-proof container in a clean environment. It is recommended to use brown dropper bottles or aluminum-plastic composite bottles to prevent photodegradation and oxidation.

[0048] Example 5 A hair follicle-activating, hair loss-preventing, and hair-growth-promoting essence, the raw materials and dosages of which are shown in Table 2 below: Table 2

[0049] The preparation method is the same as in Example 4.

[0050] Example 6 A hair follicle-activating, hair loss-preventing, and hair-growth-promoting essence, the ingredients and dosages of which are shown in Table 3 below: Table 3

[0051] The preparation method is the same as in Example 4.

[0052] Comparative Example 1 The composition was prepared according to Example 3 of Chinese Patent Application CN118662418A.

[0053] Comparative Example 2 A composition for activating hair follicles, preventing hair loss, and promoting hair growth, differing from Example 1 only in the amount of raw materials used: The composition consists of the following ingredients in parts by weight: 12 parts echinacea extract, 8 parts milk thistle extract, 22 parts fleeceflower root extract, 1 part pumpkin seed extract, 1 part Ganoderma lucidum polysaccharide, and 6 parts sea buckthorn fruit extract. The above ingredients are mixed thoroughly to obtain the composition.

[0054] The rest is the same as in Example 1.

[0055] Comparative Example 3 A composition for activating hair follicles, preventing hair loss and promoting hair growth, compared with Example 1, except that the echinacea extract is replaced with ginger extract (prepared according to the description of Example 3 in Chinese patent application CN118662418A), and the rest is the same as Example 1.

[0056] Comparative Example 4 A composition for activating hair follicles, preventing hair loss and promoting hair growth, compared with Example 1, except that milk thistle extract is replaced with arborvitae leaf extract (prepared according to the description of Example 3 in Chinese patent application CN118662418A), and the rest is the same as Example 1.

[0057] Comparative Example 5 An essence that activates hair follicles and prevents hair loss and promotes hair growth differs from Example 4 only in its active ingredients, as detailed in Table 4 below: Table 4

[0058] The rest is the same as in Example 4.

[0059] Test Example 1 5α-Reductase Inhibition Effect Test (1) Reaction system Buffer: 250 μL PBS (pH 7.4) Substrate solution: 100 μL testosterone solution (pre-dissolved in ethanol, concentration 25 μM) Enzyme solution: 500 μL 5α-reductase Coenzyme: 100 μL NADPH Test sample / control: 50 μL (the purified solution prepared in Examples 4-6 or the purified solution prepared in Comparative Example 5) (2) Operating steps Pre-incubation: Add all components except substrate and coenzyme according to Table 5 and mix. Preheat at 37°C for 5 min.

[0060] Start the reaction: Add the substrate and NADPH to start the reaction and start timing immediately (t0).

[0061] Termination of reaction: After 30 min of reaction (t30), 800 μL of methanol was added for extraction and the reaction was terminated.

[0062] Detection: Centrifuge at 12000 rpm for 10 min, collect the supernatant, and detect the concentration of DHT (dihydrotestosterone) in the supernatant by LC-MS.

[0063] (3) The grouping is shown in Table 5 below: Table 5

[0064] Note: The solvent is 1,2-hexanediol and water in a mass ratio of 1:30; The samples were the extracts prepared in Examples 4-6 or the extract prepared in Comparative Example 5.

[0065] (4) Formula for calculating inhibition rate: The inhibition rate (%) of 5α-reductase activity = [1 - (Asample - Abackground) / (Ablank - Abackground)] × 100%.

[0066] in: Asample: The concentration of the product (DHT) measured in the experimental group; Ablank: Product concentration measured in the blank control group; Abackground: Background value measured in the negative control group.

[0067] The results are shown in Table 6 below: Table 6

[0068] As shown in Table 6, the extract prepared in this embodiment of the invention has a good inhibition rate on 5α reductase activity and has a significant anti-hair loss effect.

[0069] Test Example 2 Assay for promoting mouse hair follicle cell proliferation Eighty male C57BL / 6 purebred mice weighing 15-20g were randomly divided into 8 groups. Under mild ether anesthesia, the hair on the backs of the mice was plucked using a mixture of rosin and paraffin, covering an area of ​​approximately 3cm × 4cm. The mice were then divided into a model control group and experimental groups (Examples 4-6 and Comparative Example 5). The day after hair removal, the sample was evenly applied to the plucked area on the backs of each group of mice. The dosage for each experimental group was 100μL / mouse, while the model control group received the same volume of physiological saline. The treatment was administered once daily for 14 consecutive days. After administration, the mice wore Elizabethan collars to prevent licking and for 30 minutes until absorption. Fourteen days after administration, the plucked skin was collected from the backs of the mice, fixed with formalin, and used for pathological sectioning to observe hair follicle growth. Under an optical microscope (200x magnification), three fields of view were randomly selected from each mouse to count the number of hair follicles and calculate the average value. The results are shown in Table 7.

[0070] Table 7

[0071] Note: Compared with the model control group. # P < 0.05 ## P < 0.01.

[0072] Compared with Example 1, & P < 0.05 && P < 0.01.

[0073] As shown in Table 7, the essence prepared in this embodiment of the invention can activate hair follicles and significantly improve hair growth effect.

[0074] Test Example 3 Recruiting volunteers to conduct trials on the effectiveness of hair loss prevention and hair regrowth. Seventy patients with hair loss were recruited, 80% male and 20% female, with a duration of hair loss ranging from 2 to 10 years, and ages between 20 and 60 years. They were randomly divided into 7 groups of 10 patients each. The various serum samples used in this embodiment were used as test drugs. Patients applied 2 mL of the test drugs topically or by spraying them onto the affected area twice daily (morning and evening). One course of treatment lasted 4 weeks, and four consecutive courses were administered without interruption.

[0075] Testing standards: Significant effect: No hair loss, thick hair grows in bald and sparse areas of the scalp, gradually becoming thicker and darker; Effective: No hair loss, sparse hair grows in bald or sparse areas of the scalp; Ineffective: There is hair loss, and no hair grows in the bald spots on the scalp.

[0076] The overall effective rate (including markedly effective and effective) of clinical treatment in 70 patients is shown in Table 8: Table 8

[0077] As can be seen from the data in Table 8, the essence prepared in the embodiments of the present invention has good effects in preventing hair loss, promoting hair growth, and strengthening hair.

[0078] Finally, it should be noted that the above content is only used to illustrate the technical solution of the present invention, and is not intended to limit the scope of protection of the present invention. Simple modifications or equivalent substitutions made by those skilled in the art to the technical solution of the present invention do not depart from the essence and scope of the technical solution of the present invention.

Claims

1. A composition for activating hair follicles, preventing hair loss, and promoting hair growth, characterized in that, It includes the following components: echinacea extract, milk thistle extract, fleeceflower root extract, pumpkin seed extract, Ganoderma lucidum polysaccharide, and sea buckthorn fruit extract.

2. The composition according to claim 1, characterized in that, The preparation method of the echinacea extract is as follows: after pulverizing echinacea, mix it with an ethanol aqueous solution, extract it in a gradient manner 1-3 times, combine the extracts, concentrate them, and the extract is obtained.

3. The composition according to claim 1, characterized in that, The method for preparing the milk thistle extract is as follows: milk thistle fruit is crushed and mixed with water, and then laccase, bromelain and pectin lyase are added for enzymatic hydrolysis to obtain the extract.

4. The composition according to claim 1, characterized in that, The product comprises the following ingredients by weight: 2-10 parts echinacea extract, 1-6 parts milk thistle extract, 10-20 parts fleeceflower root extract, 2-10 parts pumpkin seed extract, 3-8 parts Ganoderma lucidum polysaccharide, and 8-15 parts sea buckthorn fruit extract.

5. A method for preparing the composition according to any one of claims 1-4, characterized in that, Includes the following steps: Mix the ingredients.

6. A hair follicle-activating, hair loss-preventing, and hair-growth-promoting essence, characterized in that, The raw materials of the essence include the composition according to any one of claims 1-4 and excipients acceptable in the cosmetic field.

7. The extract according to claim 6, characterized in that, The mass of the composition is 2%-5% of the total mass of the raw materials of the extract.

8. The extract according to claim 6, characterized in that, The excipients acceptable in the cosmetics field include solvents, hair conditioning agents, and cooling agents.

9. The extract according to claim 8, characterized in that, The solvent is selected from at least one of 1,2-hexanediol, 1,3-propanediol, butylene glycol, glycerin, and water; the hair conditioning agent is selected from at least one of nicotinamide, panthenol, cyclodextrin, caffeine, and allantoin; and the cooling agent is menthol.

10. The use of the composition according to any one of claims 1-4 or the essence according to any one of claims 6-9 in the preparation of products that activate hair follicles and prevent hair loss and promote hair growth.

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