Wine desert cistanche traditional Chinese medicine decoction pieces and preparation method thereof
By combining rapid cooling and freezing with slow heating and thawing, along with vacuum steam softening, the problem of insufficient penetration of rice wine in existing technologies has been solved. This significantly improves the total phenylethanoid glycoside content and color uniformity of Cistanche deserticola medicinal slices, meeting market demand.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- HEBEI JINNUO KANG MEDICINE CO LTD
- Filing Date
- 2026-02-26
- Publication Date
- 2026-05-12
AI Technical Summary
In existing methods for preparing Cistanche deserticola medicinal slices, water soaking is insufficient to effectively break down the physical structural barrier of Cistanche tubulosa, resulting in insufficient penetration of rice wine, affecting the total phenylethanoid glycoside content, and failing to meet market demand.
The method of rapid freezing and slow thawing combined with vacuum steam softening is used to destroy the cell membrane and inner membrane, forming a large number of tiny ice crystals. Then, the cells are softened under vacuum steam, and combined with simmering and steaming in rice wine, the total phenylethanoid glycoside content and color uniformity are improved.
By combining rapid freezing and slow thawing, the total phenylethanoid glycoside content is significantly increased to >11mg/g, and the color uniformity (L value standard deviation) is <2, meeting the market demand for efficacy and color uniformity.
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Abstract
Description
Technical Field
[0001] This application relates to the field of traditional Chinese medicine processing technology, and more specifically, it relates to a medicinal herb, Cistanche deserticola, prepared by wine and its preparation method. Background Technology
[0002] Cistanche deserticola is the dried, fleshy stem with scales and leaves of *Cistanche deserticola* or *Cistanche tubulosa*, belonging to the Orobanchaceae family. It has the effects of tonifying kidney yang, nourishing essence and blood, and moistening the intestines to relieve constipation. To enhance its kidney-warming and yang-tonifying effects and moderate its laxative properties, *Cistanche deserticola* prepared with wine is often used clinically. The preparation of *Cistanche deserticola* medicinal slices mainly includes screening, washing, draining, soaking in water, slicing, drying, soaking in rice wine, steaming, and drying. In actual processing, the applicant found that soaking in water is insufficient to effectively break down the physical structure barrier of *Cistanche tubulosa*, resulting in insufficient penetration of the rice wine, affecting dissolution and thermal reactions. This resulted in a total phenylethanoid glycoside content of approximately 9 mg / g in the *Cistanche deserticola* medicinal slices, which is unsatisfactory and needs further improvement. Summary of the Invention
[0003] In order to increase the total phenylethanoid glycoside content of Cistanche deserticola medicinal slices, this application provides a Cistanche deserticola medicinal slice and its preparation method.
[0004] In the first aspect, this application provides a method for preparing Cistanche deserticola medicinal slices, using the following technical solution: A method for preparing Cistanche deserticola medicinal slices includes the following steps: S1. Screen the Cistanche tubulosa, wash it with water, drain it, and obtain pre-treated Cistanche tubulosa. S2. Spread the pretreated Cistanche deserticola and cool it to (-40)-(-30)℃ at a cooling rate of 10-15℃ / min. Freeze it for 7-9 hours and heat it to (-6)-(-4)℃ at a heating rate of 0.1-0.5℃ / min. Thaw it for 7-9 hours and then evacuate it to a vacuum degree of (-0.07)-(-0.05)MPa. Vacuum steam it at a temperature of 60-80℃ and a saturated vapor pressure for 10-20 minutes to obtain softened Cistanche deserticola. S3. Slice the softened Cistanche deserticola, spread it out and dry it to obtain Cistanche deserticola slices; S4. Mix the sliced Cistanche deserticola with rice wine and let it soak for 1-2 hours. Then spread it out and steam it at 100-110℃ for 4-5 hours. After drying, you will get the wine-processed Cistanche deserticola medicinal slices.
[0005] The method for preparing Cistanche deserticola medicinal slices disclosed in this application involves first pre-treating Cistanche tubulosa, followed by rapid freezing, slow thawing, and vacuum steam softening. Afterward, the slices are cut, dried, moistened in rice wine, steamed, and dried again to obtain the Cistanche deserticola medicinal slices. The combined use of rapid freezing, slow thawing, and vacuum steam softening results in a total phenylethanoid glycoside content >11 mg / g and a color uniformity (L value standard deviation) <2, exhibiting higher efficacy and color uniformity, thus meeting market demands.
[0006] During rapid freezing, numerous tiny ice crystals instantly form within the cells, piercing the cell membrane and inner membrane. During slow thawing, these small and unstable intracellular ice crystals melt first, followed by recondensation of the remaining larger ice crystals. This process is accompanied by an increase in the volume and morphological changes of the ice crystals, generating continuous internal compression and expansion stress on the damaged cell walls, achieving deconstruction from the inside out, breaking down the cell walls, and enhancing porosity and permeability. At temperatures of -6 to -4°C, the cells are in a state where they have been stretched open by ice crystals, but the cytoskeleton has not yet fully rebounded, i.e., the cells are in a fragile "semi-frozen and semi-thawed" state. At this time, vacuum steam softening is performed. The steam causes the residual trace ice crystals to sublimate rapidly, and it also opens the micropores of the cells, allowing them to combine with components such as the cell wall, making them soften rapidly and uniformly. This provides conditions for the subsequent dissolution and thermal reaction of the rice wine, enhancing the effect of the rice wine, and increasing the total phenylethanoid glycoside content and color uniformity.
[0007] Optionally, the moisture content of the Cistanche tubulosa is ≤10%.
[0008] By adopting the above technical solutions, the moisture content of Cistanche tubulosa is optimized, ensuring the stability of the source of Cistanche tubulosa and the consistency of the quality of Cistanche tubulosa medicinal slices.
[0009] Optionally, in step S2, during the material laying process, the material thickness is ≤6cm.
[0010] By adopting the above technical solution, the thickness of the material in step S2 is optimized to ensure the uniformity and efficiency of heat transfer. In several implementation schemes, the material thickness in step S2 is 4cm, but it can also be set to 1cm, 2cm, 3cm, 5cm, 6cm, etc., as needed, but it is not limited to the listed values. Other unlisted values within this range are also applicable.
[0011] Optionally, in step S3, the thickness of the Cistanche deserticola slices is 1-5 mm.
[0012] By adopting the above technical solution, the thickness of the Cistanche deserticola slices is optimized, which is beneficial for subsequent penetration of rice wine and heat transfer. In several implementation schemes, the thickness of the Cistanche deserticola slices is 3mm, but it can also be set to 1mm, 1.5mm, 2mm, 2.5mm, 3.5mm, 4mm, 4.5mm, 5mm, etc., as needed, but it is not limited to the listed values. Other unlisted values within this range are also applicable.
[0013] Optionally, in step S3, during the drying process of the spreading material, the thickness of the spreading material is ≤6cm, the temperature is 70-80℃, and the time is 4-6h. During the drying process, the spreading material is turned over once every 0.5-1.5h.
[0014] By adopting the above technical solution, the drying of the feed material is optimized, excess moisture is removed, and the subsequent quantitative absorption of rice wine is facilitated.
[0015] In several implementation schemes, in step S3, during the drying process of the spreading material, the spreading material thickness is 4cm, the temperature is 75℃, and the time is 5 hours, with the material being turned over every hour. The spreading material thickness can also be set to 1cm, 2cm, 3cm, 5cm, 6cm, etc., as needed; the temperature can also be set to 70℃, 73℃, 77℃, 80℃, etc., as needed; and the turning interval can also be set to 0.5 hours, 0.7 hours, 1.3 hours, 1.5 hours, etc., as needed. However, these are not limited to the listed values; other unlisted values within this range are also applicable.
[0016] Optionally, in step S4, the weight ratio of Cistanche deserticola slices to rice wine is 100:(17-23).
[0017] By adopting the above technical solution, the weight ratio of Cistanche deserticola slices and rice wine is optimized, reducing the risk of insufficient rice wine to properly soak the Cistanche deserticola slices and excessive rice wine to cause an overpowering residual alcohol taste. Furthermore, when the weight ratio of Cistanche deserticola slices to rice wine is selected within the above range, the rice wine can be fully and evenly absorbed by the Cistanche deserticola slices, achieving a moistening effect without overwatering, ensuring full conversion of medicinal efficacy, and resulting in a moderate aroma and flavor from the rice wine-processed Cistanche deserticola medicinal slices.
[0018] In several implementation schemes, in step S4, the weight ratio of Cistanche deserticola slices to rice wine is 100:20. However, the weight ratio can also be set to 100:17, 100:18, 100:19, 100:21, 100:22, 100:23, etc., as needed. But it is not limited to the listed values. Other unlisted values within this range are also applicable.
[0019] Optionally, the alcohol content of the rice wine is 12-20% vol.
[0020] By adopting the above technical solution, the alcohol content of rice wine is optimized, reducing the impact of excessively low alcohol content on penetration and extraction capabilities, and also reducing the excessive denaturation of proteins caused by excessively high alcohol content. Furthermore, selecting an alcohol content within the aforementioned range facilitates efficient dissolution and transport of active ingredients during the soaking and steaming processes, ensuring the performance and quality of the Cistanche deserticola medicinal slices.
[0021] In several implementation schemes, the alcohol content of the rice wine is 15% vol. It can also be set to 12% vol, 13% vol, 14% vol, 16% vol, 17% vol, 18% vol, 19% vol, 20% vol, etc., as needed. However, it is not limited to the listed values. Other unlisted values within this range are also applicable.
[0022] Optionally, in step S4, during the drying process of the spreading material, the thickness of the spreading material is ≤6cm, the temperature is 70-80℃, and the time is 4-6h. During the drying process, the spreading material is turned over once every 0.5-1.5h.
[0023] By adopting the above technical solutions, the drying process of the feed material is optimized, resulting in a soft and suitable texture for the Cistanche deserticola medicinal slices, with a moisture content of <9.7%, which facilitates long-term storage.
[0024] In several implementation schemes, during step S4, the drying process involves a material thickness of 4 cm, a temperature of 75°C, and a drying time of 5 hours, with the material being turned over every hour. The material thickness can also be set to 1 cm, 2 cm, 3 cm, 5 cm, 6 cm, etc., as needed; the temperature can be set to 70°C, 73°C, 77°C, 80°C, etc., as needed; and the turning interval can be set to 0.5 hours, 0.7 hours, 1.3 hours, 1.5 hours, etc., as needed. However, these are not limited to the listed values; other unlisted values within this range are also applicable.
[0025] Optionally, in step S4, during the material laying process, the material thickness is ≤6cm.
[0026] By adopting the above technical solution, the thickness of the spreading material in step S4 is optimized to ensure the uniformity and efficiency of heat transfer, as well as the full penetration of steam, thus ensuring the quality and performance of the Cistanche deserticola medicinal slices. In several implementation schemes, the spreading material thickness in step S4 is 2cm, but it can also be set to 1cm, 3cm, 4cm, 5cm, 6cm, etc., as needed, but is not limited to the listed values; other unlisted values within this range are also applicable.
[0027] Secondly, this application provides a processed herbal medicine of Cistanche deserticola, using the following technical solution: A type of Cistanche deserticola medicinal slices prepared using the aforementioned method.
[0028] In summary, this application has at least the following beneficial effects: 1. The preparation method of the Cistanche deserticola medicinal slices of this application involves first pre-treating Cistanche tubulosa, then rapidly freezing, slowly thawing, and softening with vacuum steam, followed by slicing, drying, moistening with rice wine, steaming, and drying again to obtain the Cistanche deserticola medicinal slices. Through the coordination of each step, the total phenylethanoid glycoside content is >11mg / g, and the color uniformity (L value standard deviation) is <2, exhibiting higher efficacy and color uniformity, meeting market demand.
[0029] 2. The preparation method of the Cistanche deserticola medicinal slices in this application involves rapid freezing to form numerous tiny ice crystals that pierce the cell membrane and inner membrane. Slow thawing is then employed for recrystallization. The growth, melting, and recrystallization of the ice crystals mechanically damage the cell wall and cell membrane, increasing porosity and permeability. Furthermore, vacuum steam softening is performed while the cell structure is in a fragile "semi-frozen, semi-thawed" state, allowing steam to penetrate rapidly and soften the cells uniformly. This provides conditions for subsequent fermentation and steaming in rice wine, facilitating the dissolution and transformation of active ingredients and improving the total phenylethanoid glycoside content and color uniformity. Detailed Implementation
[0030] The present application will be further described in detail below with reference to the embodiments. These embodiments are for illustrative purposes only and are not limited to the scope of application of the present application. Unless otherwise specified, the raw materials or components used in the present application can be obtained commercially or by conventional methods.
[0031] Example
[0032] Example 1 A method for preparing Cistanche deserticola medicinal slices includes the following steps: S1. Screen the Cistanche tubulosa, wash it with water, drain it, and obtain pre-treated Cistanche tubulosa.
[0033] The water content of Cistanche tubulosa is 8.7%.
[0034] S2. Spread the pretreated Cistanche deserticola to a thickness of 4 cm. Cool to -35°C at a cooling rate of 13°C / min and freeze for 8 hours. Heat to -5°C at a heating rate of 0.3°C / min and thaw for 8 hours. Then, evacuate to a vacuum degree of -0.06 MPa and perform vacuum steam treatment at 70°C and saturated vapor pressure for 15 minutes to obtain softened Cistanche deserticola.
[0035] S3. Slice the softened Cistanche deserticola into 3mm thick slices. Then spread the slices into a 4cm thick layer and dry them at 75℃ for 5 hours, turning them over every hour to obtain Cistanche deserticola slices with a thickness of 3mm.
[0036] S4. Weigh 100 kg of Cistanche deserticola slices and 20 kg of rice wine, stir for 30 minutes, and let it soak for 1.5 hours. Then spread the mixture to a thickness of 2 cm. Steam at 105℃ for 4.5 hours. Then spread the mixture to a thickness of 4 cm and dry at 75℃ for 5 hours, turning the herbs every hour to obtain the Cistanche deserticola medicinal slices.
[0037] The alcohol content of the rice wine is 15% vol, and the total sugar content is 20.0 g / L.
[0038] Example 2 A method for preparing Cistanche deserticola medicinal slices differs from Example 1 in that step S2 is different.
[0039] Step S2 specifically involves: spreading the pretreated Cistanche deserticola to a thickness of 4 cm. Cooling to -40°C at a rate of 10°C / min and freezing for 7 hours. Heating to -6°C at a rate of 0.5°C / min and thawing for 9 hours. Then, vacuum steam treatment is performed at a vacuum degree of -0.06 MPa and a saturated vapor pressure of 70°C for 15 minutes to obtain softened Cistanche deserticola.
[0040] Example 3 A method for preparing Cistanche deserticola medicinal slices differs from Example 1 in that step S2 is different.
[0041] Step S2 specifically involves: spreading the pretreated Cistanche deserticola to a thickness of 4 cm. Cooling to -30°C at a rate of 15°C / min and freezing for 9 hours. Heating to -4°C at a rate of 0.1°C / min and thawing for 7 hours. Then, vacuum steam treatment is performed at a vacuum degree of -0.06 MPa and a saturated vapor pressure of 70°C for 15 minutes to obtain softened Cistanche deserticola.
[0042] Comparative Example
[0043] Comparative Example 1 A method for preparing Cistanche deserticola medicinal slices differs from Example 1 in that step S2 is different.
[0044] Step S2 is as follows: Soak 100 kg of pretreated Cistanche deserticola in 500 kg of water for 8 hours, then remove and drain to obtain softened Cistanche deserticola.
[0045] Comparative Example 2 A method for preparing Cistanche deserticola medicinal slices differs from Example 1 in that step S2 is different.
[0046] Step S2 specifically involves spreading the pretreated Cistanche deserticola to a thickness of 4 cm. Then, a vacuum is applied to a vacuum degree of -0.06 MPa, and the mixture is subjected to vacuum steam treatment at a temperature of 70°C and saturated vapor pressure for 15 minutes to obtain softened Cistanche deserticola.
[0047] Comparative Example 3 A method for preparing Cistanche deserticola medicinal slices differs from Example 1 in that step S2 is different.
[0048] Step S2 specifically involves: spreading the pretreated Cistanche deserticola to a thickness of 4 cm. Cooling to -35°C at a rate of 0.3°C / min and freezing for 8 hours. Heating to 25°C at a rate of 0.3°C / min and thawing for 8 hours. Then, vacuuming to a vacuum degree of -0.06 MPa and vacuum steam treatment at 70°C and saturated vapor pressure for 15 minutes to obtain softened Cistanche deserticola.
[0049] Comparative Example 4 A method for preparing Cistanche deserticola medicinal slices differs from Example 1 in that step S2 is different.
[0050] Step S2 specifically involves: spreading the pretreated Cistanche deserticola to a thickness of 4 cm. Cooling to -35°C at a rate of 13°C / min and freezing for 8 hours. Heating to 25°C at a rate of 13°C / min and thawing for 8 hours. Then, vacuum steam treatment is performed at a vacuum degree of -0.06 MPa and a saturated vapor pressure of 70°C for 15 minutes to obtain softened Cistanche deserticola.
[0051] Comparative Example 5 A method for preparing Cistanche deserticola medicinal slices differs from Example 1 in that step S2 is different.
[0052] Step S2 is as follows: The pretreated Cistanche deserticola is spread into a 4cm thick layer. It is then cooled to -35℃ at a rate of 13℃ / min and frozen for 8 hours. Next, it is heated to 25℃ at a rate of 0.3℃ / min and thawed for 8 hours. Finally, a vacuum is applied to a vacuum level of -0.06MPa, and the mixture is subjected to vacuum steam treatment at 70℃ and saturated vapor pressure for 15 minutes to obtain softened Cistanche deserticola.
[0053] Performance testing The *Cistanche deserticola* medicinal slices obtained in Examples 1-3 and Comparative Examples 1-5 were used as samples. The total phenylethanoid glycoside content and color uniformity (L value standard deviation) of the *Cistanche deserticola* medicinal slices were tested according to the 2015 edition of the *Chinese Pharmacopoeia*. The test results are shown in Table 1. A higher total phenylethanoid glycoside content indicates better efficacy. A smaller color uniformity (L value standard deviation) indicates better color uniformity.
[0054] Table 1 Test Results
[0055] As shown in Table 1, the *Cistanche deserticola* medicinal slices of this application have a high total phenylethanoid glycoside content, ranging from 11.3 to 11.7 mg / g, indicating high efficacy. They also exhibit a low color uniformity (L value standard deviation), ranging from 1.5 to 1.7, demonstrating high color uniformity. The *Cistanche deserticola* medicinal slices of this application possess excellent overall performance and meet market demands.
[0056] Comparative Examples 1-2 and Example 1 were compared. In step S2 of Comparative Example 1, water soaking was used; in step S2 of Comparative Example 2, vacuum steam softening was used; in step S2 of Example 1, rapid cooling followed by freezing, slow heating followed by thawing, and then vacuum steam softening were used. It can be seen that, compared to water soaking, vacuum steam softening is beneficial for increasing the total phenylethanoid glycoside content, however the increase is limited and lower than that of this application.
[0057] Comparative Examples 3-5 and Example 1 were compared. In step S2 of Comparative Example 3, slow freezing and slow thawing to 25°C were used, followed by vacuum steam softening. In step S2 of Comparative Example 4, rapid freezing and rapid thawing to 25°C were used, followed by vacuum steam softening. In step S2 of Comparative Example 5, rapid freezing and slow thawing to 25°C were used, followed by vacuum steam softening. In step S2 of Example 1, rapid freezing and slow thawing to -5°C were used, followed by vacuum steam softening. It can be seen that rapid freezing followed by slow thawing before vacuum steam softening is beneficial for increasing the total phenylethanoid glycoside content. In particular, slow thawing to -5°C followed by vacuum steam softening can result in a total phenylethanoid glycoside content >11 mg / g. This may be because during rapid freezing, a large number of tiny ice crystals instantly form inside the cells, piercing the cell membrane and inner membrane. During slow thawing, the tiny and unstable intracellular ice crystals melt first. The meltwater then re-condenses on the remaining larger ice crystals, increasing their volume and exerting continuous expansion and pressure on the cell walls, achieving deep cell wall disruption. After slowly heating to -5°C, vacuum steam softening is performed. The 70°C steam causes the remaining trace ice crystals to sublimate rapidly. Simultaneously, the steam's heat energy is instantly transferred to the fragile, semi-frozen / semi-thawed cytoskeleton, opening micropores, rapidly softening the cells, and providing conditions for subsequent dissolution and thermal reactions in the rice wine. This enhances the rice wine's performance, increases the total phenylethanoid glycoside content, and improves color uniformity.
[0058] This specific embodiment is merely an explanation of this application and is not intended to limit it. After reading this specification, those skilled in the art can make modifications to this embodiment without contributing any inventive step, but such modifications are protected by patent law as long as they fall within the scope of the claims of this application.
Claims
1. A method for preparing Cistanche deserticola medicinal slices, characterized in that: Includes the following steps: S1. Screen the Cistanche tubulosa, wash it with water, drain it, and obtain pre-treated Cistanche tubulosa. S2. Spread the pretreated Cistanche deserticola and cool it to (-40)-(-30)℃ at a cooling rate of 10-15℃ / min. Freeze it for 7-9 hours and heat it to (-6)-(-4)℃ at a heating rate of 0.1-0.5℃ / min. Thaw it for 7-9 hours and then evacuate it to a vacuum degree of (-0.07)-(-0.05)MPa. Vacuum steam it at a temperature of 60-80℃ and a saturated vapor pressure for 10-20 minutes to obtain softened Cistanche deserticola. S3. Slice the softened Cistanche deserticola, spread it out and dry it to obtain Cistanche deserticola slices; S4. Mix the sliced Cistanche deserticola with rice wine and let it soak for 1-2 hours. Then spread it out and steam it at 100-110℃ for 4-5 hours. After drying, you will get the wine-processed Cistanche deserticola medicinal slices.
2. The method for preparing Cistanche deserticola medicinal slices according to claim 1, characterized in that: The moisture content of the Cistanche tubulosa is ≤10%.
3. The method for preparing Cistanche deserticola medicinal slices according to claim 1, characterized in that: In step S2, during the material laying process, the material thickness is ≤6cm.
4. The method for preparing Cistanche deserticola medicinal slices according to claim 1, characterized in that: In step S3, the thickness of the Cistanche deserticola slices is 1-5 mm.
5. The method for preparing Cistanche deserticola medicinal slices according to claim 1, characterized in that: In step S3, during the drying process of the spreading material, the thickness of the spreading material is ≤6cm, the temperature is 70-80℃, and the time is 4-6h. During the drying process, the spreading material is turned over once every 0.5-1.5h.
6. The method for preparing Cistanche deserticola medicinal slices according to claim 1, characterized in that: In step S4, the weight ratio of Cistanche deserticola slices to rice wine is 100:(17-23).
7. The method for preparing Cistanche deserticola medicinal slices according to claim 1, characterized in that: The alcohol content of the rice wine is 12-20% vol.
8. The method for preparing Cistanche deserticola medicinal slices according to claim 1, characterized in that: In step S4, during the drying process of the spreading material, the thickness of the spreading material is ≤6cm, the temperature is 70-80℃, and the time is 4-6h. During the drying process, the spreading material is turned over once every 0.5-1.5h.
9. The method for preparing Cistanche deserticola medicinal slices according to claim 1, characterized in that: In step S4, during the material laying process, the material thickness is ≤6cm.
10. A type of Cistanche deserticola medicinal slice, characterized in that, It is prepared using the method described in any one of claims 1-9 for preparing Cistanche deserticola medicinal slices.