Composition containing pydiflumetofen and epoxiconazole as well as preparation method and application of composition

Abstract

The invention discloses a composition containing pydiflumetofen and epoxiconazole as well as a preparation method and application of the composition, and belongs to the technical field of pesticides. The bactericidal composition disclosed by the invention takes the pydiflumetofen and the epoxiconazole as main active components, has a synergistic effect, has a wider bactericidal spectrum, particularly has an excellent synergistic prevention and treatment effect on diseases caused by fusarium and rhizoctonia, and can effectively delay the generation of drug resistance of pathogenic bacteria, improve the prevention and treatment effect and prolong the lasting period; besides, tetradecyl methyl dihydroxyethyl ammonium bromide is introduced into the modified bentonite, the bactericidal effect can be enhanced, organic silicon is introduced into the surface of the modified silicon dioxide, the modified silicon dioxide can also be adsorbed on the surfaces of bacteria, the seepage force to cell walls is enhanced, and the bactericidal effect is further improved. On the whole, the dispersion stability is excellent, particle aggregation and caking are prevented, the uniformity and stability of the product in the storage and application process are guaranteed, and the sterilization effect is more excellent.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of pesticides, in particular to a composition containing pydiflumetofen and epoxiconazole, a preparation method and application thereof. BACKGROUND

[0002] Fungal diseases are important factors restricting agricultural production. Wheat scab, rice sheath blight, peanut leaf spot, and anthracnose of fruit trees and other diseases not only cause a substantial decline in crop yield, but also seriously affect the quality of agricultural products, posing a significant threat to the sustainable development of agriculture. Chemical control is still the main means to control fungal diseases at present, but long-term single use of a certain type of fungicide has caused serious resistance problems, leading to a decline in control effect year by year and an increase in the amount of pesticide used, which not only increases the control cost, but also exacerbates environmental pressure and the risk of agricultural product quality and safety.

[0003] Pydiflumetofen is a new pyridine amide fungicide developed by Syngenta, which acts on succinate dehydrogenase. It inhibits the function of mitochondria by interfering with the tricarboxylic acid cycle on complex II of the respiratory electron transport chain, prevents it from generating energy, and inhibits the growth of pathogenic fungi, ultimately leading to their death, thereby achieving a fungicidal effect. Unlike benzimidazole, triazole, and methoxy acrylate fungicides, it is less likely to develop cross-resistance and is suitable for rotation use to delay the development of resistance. It can be used to control diseases caused by many pathogenic fungi such as Fusarium, Cercospora, Botrytis, and Alternaria, such as powdery mildew, leaf spot, brown spot, net blotch, cloud spot, gray mold, scab, early blight, black spot, and sclerotinia. However, due to the single action site of pydiflumetofen, it is a medium to high resistance risk agent, and single use can easily lead to resistance of pathogenic fungi, thereby reducing its control effect.

[0004] Fluquinconazole is a broad-spectrum, high-efficiency, and low-toxicity fungicide with strong inhibition of various fungi and bacteria. The active ingredient of fluquinconazole can effectively prevent the formation of pathogen cell walls, and has good control effect on diseases such as leaf spot, powdery mildew, and rust. It has strong systemicity, can be rapidly absorbed by crops and conducted to the infected parts, and can immediately stop the disease infection. As long as local application is performed, the disease can be completely prevented. It has a long duration on crops, generally up to 40 days or more, and excellent retention effect can effectively reduce the frequency of application and labor cost, effectively control diseases, and improve the biochemical disease resistance of crops by regulating enzyme activity. This can make the leaf color greener, thereby maximizing photosynthesis, improving crop yield, and improving crop quality.

[0005] There are also existing technologies that use fluoxastrobin and other fungicides in combination, such as Chinese Patent Application No. CN202211399249.5, which discloses a fungicidal composition containing fluoxastrobin, the active ingredients of which consist of fluoxastrobin and chlorothalonil or farnesol. The invention has good synergistic effect after mixing fluoxastrobin and chlorothalonil or farnesol, can improve the control effect on fungal diseases of crops, can reduce the dosage of pesticides, reduce costs, and reduce environmental pollution. In addition, the invention has different mechanisms of action when fluoxastrobin and chlorothalonil or farnesol are used to kill fungi, which can delay the development of pathogen resistance and reduce the risk of resistance to single fluoxastrobin application, and can extend the service life of the drug to some extent. For example, Chinese Patent Application No. CN202110592430.7 discloses a fungicidal composition containing bromoconazole and fluoxastrobin, and also discloses the application of the fungicidal composition in the prevention and control of wheat scab. The combination of bromoconazole and fluoxastrobin effectively improves the control effect on wheat scab, has a synergistic effect compared with single agents, and can reduce the amount of pesticides used and reduce costs. Although the above-mentioned existing technologies improve the effect by combining active ingredients, the overall performance of the product still needs to be improved, the influence of environmental changes on the preparation during storage is reduced, and the problems of caking and crystallization are avoided to the greatest extent, resulting in poor control effect. SUMMARY

[0006] Therefore, in order to solve one of the above technical problems, the present application provides a composition containing fluoxastrobin and epoxiconazole, a preparation method and application thereof, and the specific technical solutions are as follows: A composition containing fluoxastrobin and epoxiconazole, which comprises the following components by weight: active ingredient 5-35 parts, dispersing agent 4-12 parts, wetting agent 1-6 parts, disintegrating agent 3-12 parts, anti-caking agent 1-4 parts, binder 2-7 parts, stabilizer 1-2 parts, and modified filler 20-60 parts; The active ingredient consists of fluoxastrobin and epoxiconazole in a mass ratio of (1-5):(5-9). The modified filler is obtained by mixing modified bentonite and modified porous silica in a mass ratio of (3-5):(5-7).

[0007] Further, the preparation method of the modified bentonite is as follows: after drying the bentonite, it is dispersed in an alcohol solution of an organosilane coupling agent, stirred at a speed of 50-100 r / min for 20-30 min, then tetradecylmethyl dihydroxyethyl ammonium bromide is added, and stirring is continued for 20-40 min, and then drying is carried out at 85-100°C to obtain the modified bentonite.

[0008] Further, the ratio of the bentonite, the alcohol solution of the organosilane coupling agent, and the tetradecylmethyl dihydroxyethyl ammonium bromide is (10-20):(10-15):(1-7) by weight.

[0009] Further, the preparation method of the modified porous silica is as follows: dispersing the porous silica in a dilute sulfuric acid solution with a concentration of 1-5 wt%, stirring and treating at 60-80 DEG C for 2-4 h, filtering, washing until neutral, and drying at 100-120 DEG C to obtain the activated porous silica. adding the activated porous silica to hexamethyldisilazane, heating to 100-150 DEG C, stirring at a speed of 100-200 r / min for 30-60 min, then adding long-chain alkyl trimethoxysilane, continuing to stir for 1-2 h, filtering and washing the product, and drying at 65-85 DEG C to obtain the modified porous silica.

[0010] Further, the long-chain alkyl trimethoxysilane is at least one of octyl trimethoxysilane, dodecyl trimethoxysilane, and hexadecyl trimethoxysilane.

[0011] Further, the dispersant is at least one of lignin sulfonate, naphthalene sulfonate formaldehyde condensate sodium salt, alkyl phenol polyoxyethylene ether, and fatty acid polyoxyethylene ester.

[0012] Further, the wetting agent is at least one of sodium dodecyl benzene sulfonate and sodium dodecyl sulfate.

[0013] Further, the disintegrant is at least one of succinic acid, aluminum chloride, and anhydrous sodium sulfate.

[0014] In addition, the application also provides a preparation method of a composition containing fluoxymoxystrobin and epoxiconazole, which comprises the following steps: S1. adding active ingredients and modified fillers into a mixing kettle, stirring at a speed of 50-100 r / min for 30-60 min to obtain a mixture A; S2. adding a dispersant, a wetting agent, a disintegrant, an anti-caking agent, a binder, and a stabilizer into the mixture A, stirring at a speed of 100-500 r / min for 1-3 h, adding an appropriate amount of water in the form of spray water during the stirring process, granulating, drying at 80-90 DEG C until the water content is less than 3%, and sieving to obtain the composition.

[0015] In addition, the application also provides a use of a composition containing fluoxastrobin and epoxiconazole, and the use is the use of the composition containing fluoxastrobin and epoxiconazole in preventing and treating diseases of crops caused by Fusarium and / or Rhizoctonia.

[0016] Compared with the prior art, the application has the following beneficial effects: 1. The application uses fluoxastrobin and epoxiconazole as main active ingredients, and the two active ingredients have synergistic effect, have a wider fungicidal spectrum, and have excellent synergistic prevention and treatment effect on diseases caused by Fusarium and Rhizoctonia, can effectively delay the generation of pathogenic resistance, improve the prevention and treatment effect, and prolong the effective period; in addition, the introduction of tetradecylmethyldi-hydroxyethyl ammonium bromide into the modified bentonite can enhance the antibacterial and bactericidal effect, and the introduction of organosilicon on the surface of modified silicon dioxide can also be adsorbed on the surface of bacteria, enhance the permeability to the cell wall, and further improve the bactericidal effect.

[0017] 2. The application uses specific modified bentonite and modified porous silicon dioxide as modified fillers, which can significantly improve the dispersion stability of the composition, prevent particle agglomeration and caking, ensure the uniformity and stability of the product during storage and application, and make the bactericidal effect more excellent. The tetradecylmethyldihydroxyethyl ammonium bromide in the modified bentonite is positive, can be better chemically bonded with the bentonite, the layered structure of the modified bentonite is expanded, the interlayer spacing is expanded, and the surface is changed from hydrophilic to hydrophobic / organic phase, which significantly improves the loading capacity of the active ingredient; the modified porous silicon dioxide has excellent active ingredient adsorption capacity, and the two are compounded to form a multi-level loading structure combining macro interlayer space and micro pore, which can more efficiently accommodate active ingredients of different molecular forms and polarity, realize higher loading capacity and more firm combination, and prevent migration, crystallization (Ostwald ripening) or decomposition of the active ingredient during storage.

[0018] 3. The application has excellent prevention and treatment effect, and the overall process is simple, easy to operate and control, does not require complex equipment in the production process, is suitable for large-scale production, and has high industrialization feasibility. DETAILED DESCRIPTION

[0019] In order to make the purpose, technical scheme and advantages of the application more clear and explicit, the application is further described in detail below in combination with embodiments. It should be understood that the specific embodiments described herein are only used to explain the application, and do not limit the protection scope of the application.

[0020] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains. The terminology used herein in the description of the invention is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. The term "and / or" as used herein includes any and all combinations of one or more of the associated listed items.

[0021] An embodiment of the present invention provides a composition containing fluopyram and flutriafol, comprising the following components in parts by weight: 5-35 parts of active ingredient, 4-12 parts of dispersant, 1-6 parts of wetting agent, 3-12 parts of disintegrant, 1-4 parts of anti-caking agent, 2-7 parts of binder, 1-2 parts of stabilizer, and 20-60 parts of modified filler; The active ingredient is composed of fluopyram and flutriafol in a mass ratio of (1~5):(5~9); The modified filler is obtained by mixing modified bentonite and modified porous silica in a mass ratio of (3~5):(5~7).

[0022] In one embodiment, the modified bentonite is prepared by: drying the bentonite, dispersing it in an alcohol solution of an organosilane coupling agent, stirring at a speed of 50 r / min to 100 r / min for 20 min to 30 min, then adding tetradecylmethyldihydroxyethylammonium bromide, continuing to stir for 20 min to 40 min, and then drying at 85 °C to 100 °C to obtain the modified bentonite.

[0023] In one embodiment, the ratio of bentonite, alcoholic solution of organosilane coupling agent, and tetradecylmethyldihydroxyethylammonium bromide by weight is (10~20):(10~15):(1~7).

[0024] In one embodiment, the alcohol solution of the organosilane coupling agent is obtained by mixing the organosilane coupling agent, ethanol and water in a volume ratio of (4~7):(1~5):(1~5).

[0025] In one embodiment, the organosilane coupling agent is at least one of γ-aminopropyltriethoxysilane, vinyltriethoxysilane, and octyltriethoxysilane.

[0026] In one embodiment, the modified porous silica is prepared by dispersing porous silica in a dilute sulfuric acid solution with a concentration of 1-5 wt%, stirring at 60-80°C for 2-4 hours, filtering, washing until neutral, and drying at 100-120°C to obtain activated porous silica. Activated porous silica was added to hexamethyldisilazane, heated to 100℃~150℃, and stirred at 100r / min~200r / min for 30min~60min. Then, long-chain alkyltrimethoxysilane was added, and stirring was continued for 1h~2h. After filtration and washing, the product was dried at 65℃~85℃ to obtain modified porous silica.

[0027] In one embodiment, the ratio of activated porous silica, hexamethyldisilazane, and long-chain alkyltrimethoxysilane by weight is (4~7):(1~7):(1~9).

[0028] In one embodiment, the long-chain alkyltrimethoxysilane is at least one of octyltrimethoxysilane, dodecyltrimethoxysilane, and hexadecyltrimethoxysilane.

[0029] In one embodiment, the dispersant is at least one of lignin sulfonate, sodium naphthalene sulfonate formaldehyde condensate, alkylphenol polyoxyethylene ether, and fatty acid polyoxyethylene ester.

[0030] In one embodiment, the wetting agent is at least one of sodium dodecylbenzenesulfonate and sodium dodecyl sulfate.

[0031] In one embodiment, the disintegrant is at least one of succinic acid, aluminum chloride, and anhydrous sodium sulfate.

[0032] In one embodiment, the anti-caking agent is obtained by mixing silica and sodium dodecylbenzenesulfonate in a mass ratio of (2~7):(3~8).

[0033] In one embodiment, the adhesive is at least one of polyvinyl alcohol, polyethylene glycol, and modified cellulose polymers.

[0034] In one embodiment, the stabilizer is at least one of citric acid and epoxidized soybean oil.

[0035] In addition, the present invention also provides a method for preparing a composition containing fluopyram and flutriafol, the preparation method comprising the following steps: S1. Add the active ingredient and modified filler to a mixing vessel and stir at a speed of 50 r / min to 100 r / min for 30 min to 60 min to obtain mixture A; S2. Add the dispersant, wetting agent, disintegrant, anti-caking agent, binder and stabilizer to the mixture A, stir at a speed of 100 r / min to 500 r / min for 1 h to 3 h, and add an appropriate amount of water with spray water during the stirring process, granulate, dry at 80℃ to 90℃ until the moisture content is less than 3%, and obtain the composition after sieving.

[0036] In addition, the present invention also provides an application of a composition containing fluopyram and flutriafol, wherein the application is the use of the composition containing fluopyram and flutriafol in the prevention and control of diseases of crops caused by Fusarium and / or Rhizoctonia.

[0037] The composition containing fluopyram and flutriafol obtained by the above scheme has excellent storage and application stability, significant fungicidal effect, and plays an effective role in the prevention and control of diseases of crops caused by Fusarium and / or Rhizoctonia.

[0038] To enable those skilled in the art to better understand the technical solutions of this application, the technical solutions of this application will be described in detail below with reference to specific embodiments. The experimental materials used in the embodiments of this invention, unless otherwise specified, are all conventional experimental materials in the art and can be purchased through commercial channels. Example 1:

[0039] A method for preparing a composition containing fluopyram and flutriafol, the method comprising the following steps: S1. Add 14 parts of active ingredient and 30 parts of modified filler to a mixing vessel and stir at 50 r / min for 45 min to obtain mixture A; The active ingredient is composed of fluopyram and flutriafol in a mass ratio of 5:8. The modified filler is obtained by mixing modified bentonite and modified porous silica in a mass ratio of 4:6; The modified bentonite is prepared as follows: 20 parts by weight of dried bentonite are dispersed in an alcohol solution of 15 parts by weight of organosilane coupling agent (obtained by mixing vinyltriethoxysilane, ethanol, and water in a volume ratio of 6:2:2). The solution is stirred at 100 r / min for 25 min, then 5 parts by weight of tetradecylmethyldihydroxyethylammonium bromide are added, and the mixture is stirred for another 30 min. Finally, the solution is dried at 85°C to obtain the modified bentonite. The modified porous silica is prepared by dispersing 15 parts of porous silica in 20 parts of a 1 wt% dilute sulfuric acid solution by weight, stirring at 65°C for 3 hours, filtering, washing until neutral, and drying at 100°C to obtain activated porous silica. Seven parts of activated porous silica were added to five parts of hexamethyldisilazane, heated to 100°C, and stirred at 150 r / min for 35 min. Then, seven parts of hexadecyltrimethoxysilane were added, and stirring was continued for 1 h. The product was filtered, washed, and dried at 75°C to obtain modified porous silica. S2. Add 8 parts of fatty acid polyoxyethylene ester, 5 parts of sodium dodecylbenzenesulfonate, 7 parts of succinic acid, 1 part of anti-caking agent (obtained by mixing precipitated silica and sodium dodecylbenzenesulfonate in a mass ratio of 6:4), 5 parts of polyvinyl alcohol, and 1 part of epoxidized soybean oil to the mixture A. Stir at 300 r / min for 2 h, and add an appropriate amount of water by spraying water during the stirring process. Granulate, dry at 85°C until the moisture content is less than 3%, and sieve to obtain the composition. Example 2:

[0040] A method for preparing a composition containing fluopyram and flutriafol, the method comprising the following steps: S1. Add 13 parts of active ingredient and 30 parts of modified filler to a mixing vessel and stir at 50 r / min for 45 min to obtain mixture A; The active ingredient is composed of fluopyram and flutriafol in a mass ratio of 5:8. The modified filler is obtained by mixing modified bentonite and modified porous silica in a mass ratio of 5:5; The modified bentonite is prepared as follows: 20 parts by weight of dried bentonite are dispersed in an alcohol solution of 15 parts by weight of an organosilane coupling agent (obtained by mixing vinyltriethoxysilane, ethanol, and water in a volume ratio of 6:2:2). The solution is stirred at 100 r / min for 25 min, then 6 parts by weight of tetradecylmethyldihydroxyethylammonium bromide are added, and the mixture is stirred for another 30 min. Finally, the solution is dried at 85°C to obtain the modified bentonite. The modified porous silica is prepared by dispersing 15 parts of porous silica in 20 parts of a 1 wt% dilute sulfuric acid solution by weight, stirring at 65°C for 3 hours, filtering, washing until neutral, and drying at 100°C to obtain activated porous silica. Seven parts of activated porous silica were added to six parts of hexamethyldisilazane, heated to 100℃, and stirred at 200 r / min for 40 min. Then, eight parts of hexadecyltrimethoxysilane were added, and stirring was continued for 1 h. The product was filtered, washed, and dried at 80℃ to obtain modified porous silica. S2. Add 10 parts of fatty acid polyoxyethylene ester, 6 parts of sodium dodecylbenzenesulfonate, 8 parts of succinic acid, 1 part of anti-caking agent (obtained by mixing silica and sodium dodecylbenzenesulfonate in a mass ratio of 6:4), 6 parts of polyvinyl alcohol, and 1 part of epoxidized soybean oil to the mixture A. Stir at 300 r / min for 2 h, and add an appropriate amount of water by spraying water during the stirring process. Granulate, dry at 85°C until the moisture content is less than 3%, and sieve to obtain the composition. Example 3:

[0041] A method for preparing a composition containing fluopyram and flutriafol, the method comprising the following steps: S1. Add 13 parts of active ingredient and 30 parts of modified filler to a mixing vessel and stir at 50 r / min for 45 min to obtain mixture A; The active ingredient is composed of fluopyram and flutriafol in a mass ratio of 5:8. The modified filler is obtained by mixing modified bentonite and modified porous silica in a mass ratio of 4:6; The modified bentonite is prepared as follows: 20 parts by weight of dried bentonite are dispersed in an alcohol solution of 15 parts by weight of organosilane coupling agent (obtained by mixing vinyltriethoxysilane, ethanol, and water in a volume ratio of 6:2:2). The solution is stirred at 100 r / min for 25 min, then 7 parts by weight of tetradecylmethyldihydroxyethylammonium bromide are added, and the mixture is stirred for another 35 min. Finally, the solution is dried at 85°C to obtain the modified bentonite. The modified porous silica is prepared by dispersing 15 parts of porous silica in 20 parts of a 1 wt% dilute sulfuric acid solution by weight, stirring at 75°C for 3 hours, filtering, washing until neutral, and drying at 100°C to obtain activated porous silica. Seven parts of activated porous silica were added to seven parts of hexamethyldisilazane, heated to 100°C, and stirred at 200 r / min for 40 min. Then, eight parts of hexadecyltrimethoxysilane were added, and stirring was continued for 1 h. The product was filtered, washed, and dried at 85°C to obtain modified porous silica. S2. Add 10 parts of fatty acid polyoxyethylene ester, 5 parts of sodium dodecylbenzenesulfonate, 7 parts of succinic acid, 1 part of anti-caking agent (obtained by mixing precipitated silica and sodium dodecylbenzenesulfonate in a mass ratio of 6:4), 7 parts of polyvinyl alcohol, and 2 parts of epoxidized soybean oil to the mixture A. Stir at 300 r / min for 2 h, and add an appropriate amount of water by spraying during the stirring process. Granulate, dry at 85°C until the moisture content is less than 3%, and sieve to obtain the composition.

[0042] Comparative Example 1: The difference between Comparative Example 1 and Example 1 is that no flutriafol was added in Comparative Example 1, but otherwise the same as in Example 1.

[0043] Comparative Example 2: Comparative Example 2: The difference between Comparative Example 2 and Example 1 is that no fluopyram was added in Comparative Example 2, but otherwise it was the same as Example 1.

[0044] Comparative Example 3: The difference between Comparative Example 3 and Example 1 is that the modified bentonite in Comparative Example 3 did not contain tetradecylmethyldihydroxyethylammonium bromide, while the rest was the same as in Example 1.

[0045] Comparative Example 4: The difference between Comparative Example 4 and Example 1 is that no modified bentonite was added to the modified filler in Comparative Example 4, but otherwise it is the same as Example 1.

[0046] Comparative Example 5: The difference between Comparative Example 5 and Example 1 is that no hexadecyltrimethoxysilane (long-chain alkyltrimethoxysilane) was added to the modified porous silica of Comparative Example 5; otherwise, they were the same as in Example 1.

[0047] Comparative Example 6: The difference between Comparative Example 6 and Example 1 is that no modified porous silica was added to the modified filler in Comparative Example 6, but otherwise it is the same as Example 1.

[0048] Comparative Example 7: The difference between Comparative Example 7 and Example 1 is that no anti-caking agent was added in Comparative Example 7, but otherwise it is the same as Example 1.

[0049] I. Stability tests were conducted on the composition samples prepared in Examples 1-3 and Comparative Examples 1-7. The samples were stored at 55±2℃ for 14 days as hot storage, and at -2±2℃ for 14 days as cold storage. The content of the active ingredient in the samples after the expiration date was determined by liquid chromatography. The difference between the content in the hot and cold storage was compared to the content in the cold storage, which is the decomposition rate. The decomposition rate of the qualified product should not exceed 5% under both hot and cold storage. The results are shown in Table 1 below.

[0050] Table 1: Stability Tests

[0051] As can be seen from the data analysis in Table 1, the present invention has better overall stability after optimizing the composition of the composition, and the introduction of modified filler effectively inhibits the thermal decomposition of active ingredients. The main active ingredients in Examples 1 and 2 were altered, affecting the control effect. Compared with Example 1, Comparative Example 3 did not contain modified bentonite with tetradecylmethyldihydroxyethylammonium bromide, indicating that the addition of tetradecylmethyldihydroxyethylammonium bromide can enhance structural stability. Comparative Example 4 did not contain modified bentonite in its modified filler, resulting in a significant decrease in stability, indicating that modified bentonite can improve the loading stability of active ingredients. Comparative Example 5 did not contain hexadecyltrimethoxysilane (long-chain alkyltrimethoxysilane) in its modified porous silica, resulting in decreased stability. Comparative Example 6 did not contain modified porous silica in its modified filler, resulting in a significant increase in decomposition rate. From Comparative Examples 4 to 6, it can be seen that the modified bentonite and modified silica added in this invention have an interaction between the components, which can effectively improve the stability of the composition. Comparative Example 7 did not contain an anti-caking agent, but its stability decreased, indicating that the anti-caking agent of this invention inhibits the migration, crystallization, and decomposition of active ingredients.

[0052] II. Further field trials of wheat scab control were conducted on the composition samples prepared in Examples 1-3 and Comparative Examples 1-7. The pesticides were applied before wheat flowering according to the requirements in the table below. The first application was carried out, and the second application was carried out 7 days later. The disease index was measured at 7, 14 and 21 days after the application, and the efficacy percentage was calculated. The results are shown in Table 2.

[0053] Table 2: Results of drug efficacy in controlling wheat scab

[0054] Analysis of the data in Table 2 shows that the composition of the present invention maintained a efficacy of over 85% at 7, 14, and 21 days, demonstrating excellent rapid and sustained efficacy. Compared with Example 1, Comparative Examples 1 and 2 did not contain a single active ingredient, resulting in significantly lower efficacy than Example 1. This indicates that the present invention combines fluopyram and flutriafol, resulting in better control effects. Comparative Example 3, with its modified bentonite, lacked the synergistic antibacterial and bactericidal effects of tetradecylmethyldihydroxyethyl ammonium bromide, weakening its adsorption and penetration into the bacterial cell walls, leading to a lower control effect than Example 1. Comparative Example 4, without modified bentonite, showed significantly lower control effects than Example 1, indicating that the modified bentonite... Modified bentonite enhances the loading and sustained-release capacity of the active ingredient and assists in sterilization. Comparative Example 5, which uses modified porous silica without long-chain alkyltrimethoxysilane, showed a worse control effect than Example 1, indicating that silane modification enhances the hydrophobicity and adsorption of silica, facilitating the stable release of the active ingredient. Comparative Example 6, which did not add modified porous silica, showed decreased stability in the composition, preventing the active ingredient from achieving optimal sterilization. Comparative Example 7, which did not add an anti-caking agent, showed lower stability in the composition compared to Example 1, negatively impacting the control effect. Overall, this demonstrates that the compositions of this application, through scientific formulation, can achieve better sterilization and superior sterilization effects.

[0055] The above description is merely a preferred embodiment of the present invention; however, the scope of protection of the present invention is not limited thereto. Any equivalent substitutions or modifications made by those skilled in the art within the scope of the technology disclosed in the present invention, based on the technical solution and its improved concepts, should be covered within the scope of protection of the present invention.

Claims

1. A composition containing fluopyram and flutriafol, characterized in that, It comprises the following components in parts by weight: 5 to 35 parts of active ingredient, 4 to 12 parts of dispersant, 1 to 6 parts of wetting agent, 3 to 12 parts of disintegrant, 1 to 4 parts of anti-caking agent, 2 to 7 parts of binder, 1 to 2 parts of stabilizer, and 20 to 60 parts of modified filler; The active ingredient is composed of fluopyram and flutriafol in a mass ratio of (1~5):(5~9); The modified filler is obtained by mixing modified bentonite and modified porous silica in a mass ratio of (3~5):(5~7).

2. The composition according to claim 1, characterized in that, The modified bentonite is prepared by: drying the bentonite, dispersing it in an alcohol solution of an organosilane coupling agent, stirring at a speed of 50 r / min to 100 r / min for 20 min to 30 min, then adding tetradecylmethyldihydroxyethylammonium bromide, continuing to stir for 20 min to 40 min, and then drying at 85℃ to 100℃ to obtain the modified bentonite.

3. The composition according to claim 2, characterized in that, The ratio of bentonite, the alcoholic solution of organosilane coupling agent, and tetradecylmethyldihydroxyethylammonium bromide by weight is (10~20):(10~15):(1~7).

4. The composition according to claim 1, characterized in that, The modified porous silica is prepared by dispersing porous silica in a dilute sulfuric acid solution with a concentration of 1-5 wt%, stirring at 60-80°C for 2-4 hours, filtering, washing until neutral, and drying at 100-120°C to obtain activated porous silica. Activated porous silica was added to hexamethyldisilazane, heated to 100℃~150℃, and stirred at 100r / min~200r / min for 30min~60min. Then, long-chain alkyltrimethoxysilane was added, and stirring was continued for 1h~2h. After filtration and washing, the product was dried at 65℃~85℃ to obtain modified porous silica.

5. The composition according to claim 4, characterized in that, The long-chain alkyltrimethoxysilane is at least one of octyltrimethoxysilane, dodecyltrimethoxysilane, and hexadecyltrimethoxysilane.

6. The composition according to claim 1, characterized in that, The dispersant is at least one of lignin sulfonate, sodium salt of naphthalene sulfonate formaldehyde condensate, alkylphenol polyoxyethylene ether, and fatty acid polyoxyethylene ester.

7. The composition according to claim 1, characterized in that, The wetting agent is at least one of sodium dodecylbenzenesulfonate and sodium dodecyl sulfate.

8. The composition according to claim 1, characterized in that, The disintegrant is at least one of succinic acid, aluminum chloride, and anhydrous sodium sulfate.

9. A method for preparing a composition containing fluopyram and flutriafol, characterized in that, The preparation method is used to prepare the composition containing fluopyram and flutriafol as described in any one of claims 1 to 8, and the preparation method includes the following steps: S1. Add the active ingredient and modified filler to a mixing vessel and stir at a speed of 50 r / min to 100 r / min for 30 min to 60 min to obtain mixture A; S2. Add the dispersant, wetting agent, disintegrant, anti-caking agent, binder and stabilizer to the mixture A, stir at a speed of 100 r / min to 500 r / min for 1 h to 3 h, and add an appropriate amount of water with spray water during the stirring process, granulate, dry at 80℃ to 90℃ until the moisture content is less than 3%, and obtain the composition after sieving.

10. The application of a composition containing fluopyram and flutriafol, characterized in that, The application refers to the use of the composition of fluopyram and flutriafol as described in any one of claims 1 to 8 in the prevention and control of diseases of crops caused by Fusarium and / or Rhizoctonia.

Images