Traditional Chinese medicine ointment capable of consolidating foundation and dredging collaterals for treating hypertension, abnormal glucose tolerance and dyslipidemia

Abstract

The invention provides a foundation-consolidating and vessel-dredging traditional Chinese medicine ointment for treating hypertension, abnormal glucose tolerance and dyslipidemia, and belongs to the field of traditional Chinese medicine preparations for treating metabolic syndromes. The traditional Chinese medicine ointment is prepared from the following traditional Chinese medicines: calcined dragon bone, calcined oyster shell, ligusticum wallichii, gynostemma pentaphyllum, rhizoma alismatis, radix puerariae, radix salviae miltiorrhizae, pericarpium trichosanthis, wild chrysanthemum flower, poria with hostwood, astragalus membranaceus, earthworm, radix bupleuri, gastrodia elata, uncaria rhynchophylla, plum blossom, fingered citron, dendrobe, rhizoma anemarrhenae, schisandra chinensis, glossy privet fruit, gardenia, cicada slough, turtle shell, tortoise-shell glue, rice sprout, malt, Chinese yam, poria cocos and the like. Based on the theory of treating different diseases at the same time in the traditional Chinese medicine, the ointment is used for integrally conditioning the common core pathogenesis of yin deficiency and yang hyperactivity, damp-heat accumulation and blood stasis blocking collaterals of hypertension, abnormal glucose tolerance and dyslipidemia, and integrates the functions of nourishing yin and suppressing yang, clearing heat and promoting diuresis, promoting blood circulation to remove meridian obstruction and replenishing qi to invigorate the spleen, so that multi-target intervention of reducing blood pressure, reducing blood sugar and regulating blood fat is realized; the traditional Chinese medicine composition is especially suitable for preventing and treating multiple metabolic disorders of the metabolic syndrome, treats both symptoms and root causes, and can achieve a good clinical effect.

Description

Technical Field

[0001] This invention belongs to the field of traditional Chinese medicine preparations for the treatment of metabolic syndrome, specifically involving a traditional Chinese medicine ointment for treating hypertension, impaired glucose tolerance, and dyslipidemia. Background Technology

[0002] Hypertension, impaired glucose tolerance, and dyslipidemia are the three most common metabolic diseases in clinical practice. They often coexist, are mutually causal, and together constitute the main risk factors for cardiovascular and cerebrovascular diseases. Hypertension is characterized by persistently elevated systemic arterial blood pressure, which can lead to damage to target organs such as the heart, brain, and kidneys. Impaired glucose tolerance is characterized by elevated blood glucose levels due to insulin resistance and pancreatic β-cell dysfunction; long-term hyperglycemia can cause microvascular and macrovascular complications. Dyslipidemia is mainly manifested by elevated serum total cholesterol, triglycerides, and low-density lipoprotein cholesterol, and decreased high-density lipoprotein cholesterol, directly promoting the occurrence and development of atherosclerosis. When all three coexist, they form the so-called "metabolic syndrome," significantly increasing the risk of endpoint events such as myocardial infarction and stroke.

[0003] Currently, modern medicine mainly uses a combination of antihypertensive, hypoglycemic, and lipid-regulating drugs to treat the above three diseases, such as angiotensin-converting enzyme inhibitors, metformin, and statins. Although these drugs can effectively control the indicators, they often require long-term or even lifelong medication and have limitations such as drug side effects, poor compliance, and difficulty in comprehensively regulating multiple metabolic disorders.

[0004] Based on the theory of "treating different diseases with the same method", traditional Chinese medicine, starting from the holistic view and based on syndrome differentiation and treatment, has shown unique advantages in improving symptoms, delaying complications and improving quality of life, and has provided new ideas for the comprehensive prevention and treatment of such diseases. Summary of the Invention

[0005] The technical problem to be solved by this invention is to provide a traditional Chinese medicine plaster for treating hypertension, impaired glucose tolerance, and dyslipidemia. This plaster is formulated according to the principle of monarch, minister, assistant, and guide in traditional Chinese medicine. Based on the theory of "treating different diseases with the same method" in traditional Chinese medicine, it holistically regulates the core pathogenesis of hypertension, impaired glucose tolerance, and dyslipidemia, which are "yin deficiency and yang hyperactivity, internal damp-heat, and blood stasis obstructing the collaterals". It integrates nourishing yin and suppressing yang, clearing heat and removing dampness, promoting blood circulation and unblocking collaterals, and invigorating qi and strengthening the spleen, so as to achieve multi-target intervention of lowering blood pressure, lowering blood sugar, and regulating blood lipids. It is especially suitable for the prevention and treatment of "multiple metabolic disorders" in metabolic syndrome, treating both the symptoms and the root cause, and can achieve good clinical results.

[0006] To achieve the above objectives, the technical solution adopted by the present invention is as follows:

[0007] A traditional Chinese medicine plaster for treating hypertension, impaired glucose tolerance, and dyslipidemia, prepared from the following medicinal ingredients by weight:

[0008] Calcined dragon bone 240-260g, calcined oyster shell 240-260g, Sichuan lovage rhizome 90-110g, Gynostemma pentaphyllum 290-310g, Alisma plantago-aquatica 170-190g, Pueraria lobata root 290-310g, Salvia miltiorrhiza root 190-210g, Trichosanthes kirilowii peel 240-260g, Chrysanthemum indicum 190-210g, Poria cocos 170-190g, Astragalus membranaceus root 170-190g, Pheretima aspergillum 90-110g, Bupleurum chinense root 140-160g, Gastrodia elata rhizome 240-260g, Uncaria rhynchophylla rhizome 110-130g, Prunus mume flower 150-170g, Citrus medica fruit 170-190g, Dendrobium nobile 170-190g, Anemarrhena asphodeloides 170-190g, Schisandra chinensis 110-130g, Ligustrum lucidum 170-190g, Gardenia jasminoides 170-190g, Cicadae periostracum 190-210g, Trionyx sinensis 240-260g, Tortoise shell glue 50-70g, Germinated barley 170-190g, Germinated wheat 170-190g, Dioscorea opposita 290-310g, Amomum villosum 30g, Atractylodes macrocephala 170-190g, Citrus reticulata 140-160g, Taraxacum mongolicum 290-310g, Chrysanthemum morifolium 170-190g, Magnolia officinalis 170-190g, Poria cocos 170-190g.

[0009] The formula for this herbal plaster for strengthening the body and promoting blood circulation includes the following explanations of each herb:

[0010] Calcined Dragon Bone

[0011] [Properties and Channels Entered] Sweet, astringent, neutral. Enters the Heart, Liver, and Kidney channels.

[0012]

Functions

[0013]

Applications

[0014] [Modern Pharmacology] Sedative, anticonvulsant, promotes coagulation, calcium supplementation, etc.

[0015] Calcined oyster shell

[0016] [Properties and Channels Entered] Salty, slightly cold. Enters the Liver, Gallbladder, and Kidney channels.

[0017]

Functions

[0018]

Applications

[0019] [Modern Pharmacology] Immunomodulatory, antioxidant, antitumor, and hepatoprotective effects.

[0020] Chuanxiong

[0021] [Properties and Channels Entered] Pungent, warm. Enters the Liver, Gallbladder, and Pericardium channels.

[0022]

Function

[0023]

Applications

[0024] [Modern Pharmacology] It dilates blood vessels, improves microcirculation, inhibits platelet aggregation, has antithrombotic, sedative and analgesic effects.

[0025] Gynostemma pentaphyllum

[0026] [Properties and Channels Entered] Cold, bitter. Enters the Lung, Spleen, and Kidney channels.

[0027]

Functions

[0028] [Application] Physical weakness and fatigue, and seminal emission due to overwork.

[0029] [Modern Pharmacology] Regulates immunity, lowers blood lipids, combats fatigue, has antioxidant properties, and protects the cardiovascular system and liver.

[0030] Alisma plantago-aquatica

[0031] [Properties and Channels Entered] Sweet, bland, cold. Enters the Kidney and Bladder channels.

[0032] [Functions] It promotes diuresis and eliminates dampness, clears heat, and reduces turbidity and lipids.

[0033]

Applications

[0034] [Modern Pharmacology] It has diuretic and anti-edema effects, lowers blood lipids, resists arteriosclerosis, protects the liver, and inhibits stone formation.

[0035] Kudzu root

[0036] [Properties and Channels Entered] Sweet, pungent, cool. Enters the spleen, stomach, and lung channels.

[0037]

Functions

[0038]

Applications

[0039] [Modern Pharmacology] It dilates coronary arteries, improves myocardial ischemia, lowers blood sugar, reduces fever, and relieves muscle spasms.

[0040] Salvia miltiorrhiza

[0041] [Properties and Channels Entered] Bitter, slightly cold. Enters the Heart and Liver channels.

[0042]

Functions

[0043]

Applications

[0044] [Modern Pharmacology] Improves blood rheology, anticoagulates, protects the myocardium, has antioxidant properties, and promotes tissue repair.

[0045] Trichosanthes peel

[0046] [Properties and Channels Entered] Sweet, cold. Enters the Lung and Stomach channels.

[0047]

Function

[0048] [Application] Treats cough with phlegm and heat, chest tightness and rib pain.

[0049] [Modern Pharmacology] Antibacterial, antitumor, lipid-lowering, antioxidant, anti-myocardial ischemia, diuretic and antihypertensive effects.

[0050] wild chrysanthemum

[0051] [Properties and Channels Entered] Bitter, pungent, slightly cold. Enters the Liver and Heart channels.

[0052]

Functions

[0053]

Applications

[0054] [Modern Pharmacology] Antibacterial and antiviral, anti-inflammatory, antihypertensive, immune-enhancing, and cardiovascular-protective.

[0055] Poria cocos

[0056] [Properties and Channels Entered] Sweet, neutral. Enters the Heart and Spleen channels.

[0057]

Functions

[0058] [Application] Used to treat palpitations due to heart deficiency, forgetfulness, insomnia, epilepsy, and difficulty urinating.

[0059] [Modern Pharmacology] It has sedative and tumor-inhibiting effects.

[0060] Astragalus

[0061] [Properties and Channels Entered] Sweet, slightly warm. Enters the Lung and Spleen channels.

[0062]

Functions

[0063]

Applications

[0064] [Modern Pharmacology] Enhances immunity, strengthens the heart, protects the liver, promotes diuresis, has anti-aging effects, and lowers blood pressure and blood sugar.

[0065] earth dragon

[0066] [Properties and Channels Entered] Salty, cold. Enters the Liver, Spleen, and Bladder channels.

[0067]

Functions

[0068] [Applications] Used for high fever with delirium, convulsions, joint pain, numbness of limbs, hemiplegia, cough with lung heat, edema and oliguria.

[0069] [Modern Pharmacology] Antithrombotic, thrombolytic, antihypertensive, anticonvulsant, antipyretic, immune-enhancing and antitumor.

[0070] Bupleurum

[0071] [Properties and Channels Entered] Pungent, bitter, slightly cold. Enters the Liver, Gallbladder, and Lung channels.

[0072]

Functions

[0073] [Applications] Used for colds with fever, alternating chills and fever, chest and rib pain, irregular menstruation, uterine prolapse, and rectal prolapse.

[0074] [Modern Pharmacology] Antipyretic and anti-inflammatory, hepatoprotective and choleretic, lipid-lowering, immunomodulatory and antiviral effects.

[0075] Gastrodia elata

[0076] [Properties and Channels Entered] Sweet, neutral. Enters the Liver channel.

[0077]

Functions

[0078]

Applications

[0079] [Modern Pharmacology] Sedative, anticonvulsant, neuroprotective and circulatory-improving effects.

[0080] Uncaria rhynchophylla

[0081] [Properties and Channels Entered] Sweet, cool. Enters the Liver and Pericardium channels.

[0082]

Functions

[0083]

Applications

[0084] [Modern Pharmacology] It has sedative, anticonvulsant, antihypertensive and antiplatelet aggregation effects.

[0085] Green plum blossoms

[0086] [Properties and Channels Entered] Slightly sour, neutral. Enters the Liver, Stomach, and Lung channels.

[0087]

Functions

[0088]

Applications

[0089] [Modern Pharmacology] It has anti-inflammatory, antioxidant, and antibacterial effects, and can regulate gastrointestinal function, protect the liver, and have a sedative effect.

[0090] Buddha's Hand

[0091] [Properties and Channels Entered] Pungent, bitter, sour, warm. Enters the Liver, Spleen, Stomach, and Lung channels.

[0092]

Functions

[0093]

Applications

[0094] [Modern Pharmacology] It has the effects of inhibiting intestinal smooth muscle, dilating coronary arteries, lowering blood pressure, relieving asthma and expectoration, and enhancing immunity.

[0095] Dendrobium

[0096] [Properties and Channels Entered] Sweet, slightly cold. Enters the Stomach and Kidney channels.

[0097]

Functions

[0098]

Applications

[0099] [Modern Pharmacology] Enhances immunity, has antioxidant properties, lowers blood sugar, protects the gastric mucosa, and promotes saliva secretion.

[0100] Anemarrhena asphodeloides

[0101] [Properties and Channels Entered] Bitter, sweet, cold. Enters the Lung, Stomach, and Kidney channels.

[0102]

Functions

[0103]

Applications

[0104] [Modern Pharmacology] Antibacterial and antiviral, anti-inflammatory, hypoglycemic, immunomodulatory and tumor cell inhibitory.

[0105] Schisandra chinensis

[0106] [Properties and Channels Entered] Sour, sweet, warm. Enters the lung, heart, and kidney channels.

[0107]

Functions

[0108]

Applications

[0109] [Modern Pharmacology] Sedative, hepatoprotective, immune-enhancing, antioxidant, and regulatory of the cardiovascular and respiratory systems.

[0110] Privet

[0111] [Properties and Channels Entered] Sweet, bitter, cool. Enters the liver and kidney channels.

[0112] [Function] Nourishes the liver and kidneys, improves eyesight and darkens hair.

[0113]

Applications

[0114] [Modern Pharmacology] Enhances immunity, protects the liver, lowers blood lipids, anti-aging, increases white blood cell count and has anti-tumor effects.

[0115] Gardenia

[0116] [Properties and Channels Entered] Bitter, cold. Enters the Heart, Lung, and Triple Burner channels.

[0117]

Functions

[0118]

Applications

[0119] [Modern Pharmacology] It promotes bile secretion, protects the liver, lowers blood pressure, sedates, reduces inflammation, stops bleeding, and inhibits pathogenic microorganisms.

[0120] free oneself

[0121] [Properties and Channels Entered] Sweet, cold. Enters the Lung and Liver channels.

[0122]

Functions

[0123]

Applications

[0124] [Modern Pharmacology] Anticonvulsant, sedative, antipyretic, anti-allergic, immunosuppressive and renal protective effects.

[0125] turtle shell

[0126] [Properties and Channels Entered] Salty, slightly cold. Enters the Liver and Kidney channels.

[0127]

Functions

[0128]

Applications

[0129] [Modern Pharmacology] Enhances immunity, combats fatigue, fights tumors, inhibits connective tissue proliferation, and replenishes blood.

[0130] Tortoise shell glue

[0131] [Properties and Channels Entered] Sweet, salty, cool. Enters the Liver, Kidney, and Heart channels.

[0132]

Functions

[0133]

Applications

[0134] [Modern Pharmacology] Enhances immunity, combats fatigue, improves hypoxia tolerance, improves hematopoietic function, stops bleeding, has antioxidant properties, delays aging, and regulates endocrine function.

[0135] Gu bud

[0136] [Properties and Channels Entered] Sweet, warm. Enters the spleen and stomach channels.

[0137]

Function

[0138] [Applications] Used for indigestion, abdominal distension, halitosis, weak spleen and stomach, and poor appetite. Roasted germinated rice is better at aiding digestion and is used for poor appetite and lack of hunger. Charred germinated rice is good at resolving stagnation and is used for indigestion.

[0139] [Modern Pharmacology] Promotes digestion, regulates gastrointestinal motility, lowers blood lipids, has antioxidant properties and protects the liver.

[0140] malt

[0141] [Properties and Channels Entered] Sweet, neutral. Enters the spleen and stomach channels.

[0142]

Functions

[0143]

Applications

[0144] [Modern Pharmacology] Promotes digestion, suppresses lactation, lowers blood sugar, regulates gastrointestinal motility, and protects liver function.

[0145] yam

[0146] [Properties and Channels Entered] Sweet, neutral. Enters the spleen, lung, and kidney channels.

[0147] [Functions] Tonifies the spleen and stomach, promotes the production of body fluids and benefits the lungs, and tonifies the kidneys and astringes essence.

[0148] [Applications] Used for spleen deficiency with poor appetite, chronic diarrhea, lung deficiency with cough and wheezing, kidney deficiency with seminal emission, leukorrhea, frequent urination, and thirst due to deficiency heat.

[0149] [Modern Pharmacology] Enhances immunity, lowers blood sugar, has antioxidant properties, regulates gastrointestinal motility, and protects the kidneys.

[0150] Amomum villosum

[0151] [Properties and Channels Entered] Pungent, warm. Enters the spleen, stomach, and kidney channels.

[0152]

Functions

[0153]

Applications

[0154] [Modern Pharmacology] It has the effects of regulating gastrointestinal motility, anti-ulcer, anti-platelet aggregation, analgesia and anti-inflammation.

[0155] Atractylodes macrocephala

[0156] [Properties and Channels Entered] Bitter, sweet, warm. Enters the spleen and stomach channels.

[0157]

Functions

[0158] [Application] Used for spleen deficiency with poor appetite, abdominal distension and diarrhea, phlegm retention with dizziness and palpitations, edema, spontaneous sweating, and threatened abortion.

[0159] [Modern Pharmacology] Diuretic, hypoglycemic, immune-enhancing, liver-protective, gastrointestinal motility-regulating, and anti-tumor.

[0160] Dried tangerine peel

[0161] [Properties and Channels Entered] Bitter, pungent, warm. Enters the Lung and Spleen channels.

[0162]

Functions

[0163] [Application] Used for abdominal distension, poor appetite, vomiting and diarrhea, and cough with excessive phlegm.

[0164] [Modern Pharmacology] Regulates gastrointestinal motility, expectorant, antiasthmatic, anti-inflammatory, antioxidant and cardiovascular protective.

[0165] Dandelion

[0166] [Properties and Channels Entered] Bitter, sweet, cold. Enters the Liver and Stomach channels.

[0167]

Functions

[0168]

Applications

[0169] [Modern Pharmacology] Antibacterial, antiviral, anti-inflammatory, choleretic, hepatoprotective, immune-enhancing and anti-tumor.

[0170] chrysanthemum

[0171] [Properties and Channels Entered] Sweet, bitter, slightly cold. Enters the Lung and Liver channels.

[0172]

Functions

[0173]

Applications

[0174] [Modern Pharmacology] It dilates coronary arteries, lowers blood pressure, and has antibacterial, antiviral, anti-inflammatory, and antioxidant effects.

[0175] Magnolia officinalis

[0176] [Properties and Channels Entered] Bitter, pungent, warm. Enters the spleen, stomach, lung, and large intestine channels.

[0177]

Function

[0178]

Applications

[0179] [Modern Pharmacology] Antibacterial, anti-ulcer, regulates gastrointestinal motility, muscle relaxant and antiplatelet aggregation.

[0180] Poria

[0181] [Properties and Channels Entered] Sweet, bland, neutral. Enters the Heart, Lung, Spleen, and Kidney channels.

[0182] [Functions] It promotes diuresis and eliminates dampness, strengthens the spleen, and calms the mind.

[0183]

Applications

[0184] [Modern Pharmacology] Diuretic, immune-enhancing, anti-tumor, liver-protective, sedative, and gastrointestinal function regulating.

[0185] The herbal plaster for strengthening the body and unblocking the meridians proposed in this invention follows the TCM theory of "treating different diseases with the same method." The formula is based on the principles of strengthening the body and nourishing the source, unblocking the meridians and clearing away turbidity, calming the liver and extinguishing wind, nourishing yin and clearing heat, soothing the liver and harmonizing the stomach, and strengthening the spleen and removing dampness. Astragalus, yam, calcined dragon bone, and calcined oyster shell are the chief ingredients. Astragalus invigorates qi and strengthens the spleen, raises yang and consolidates the exterior, while yam nourishes the spleen and stomach, benefits the kidneys and consolidates essence. The two complement each other to strengthen the foundation of the spleen and kidneys, targeting the core deficiency of metabolic syndrome. Calcined dragon bone and calcined oyster shell suppress yang and calm the mind, directly addressing the key pathogenesis of hypertension with liver yang hyperactivity. The four herbs work together to treat both the root cause and the symptoms, relieving core symptoms such as dizziness, headache, fatigue, irritability and insomnia. The formula consists of Danshen, Chuanxiong, Gegen, Dilong, Tianma, Gou Teng, Biejia, Guijiajiao, Nuzhenzi, and Shihu as the assistant herbs. Danshen, Chuanxiong, and Gegen invigorate blood circulation, clear the meridians, and promote the upward movement of clear qi and downward movement of turbid qi. Dilong clears the meridians, invigorates blood circulation, clears heat, and calms the nerves. The four herbs work together to clear blood stasis and improve the poor circulation and numbness of limbs caused by hypertension, hyperlipidemia, and hyperglycemia. Tianma and Gou Teng calm the liver, extinguish wind, clear heat, and calm the nerves, assisting the principal herbs in calming liver wind and stabilizing blood pressure, thus strengthening the symptomatic treatment of dizziness and vertigo caused by hypertension. Biejia and Guijiajiao nourish yin and subdue yang, soften hardness and dissipate nodules. Nuzhenzi and Shihu nourish the liver and kidneys, nourish yin and generate fluids. The four herbs target the symptoms of yin deficiency and dryness due to impaired glucose tolerance and long-term yin depletion due to hypertension. They not only nourish the yin of the liver and kidneys to control yang hyperactivity, but also nourish fluids to relieve thirst, while also addressing the symptoms of phlegm and blood stasis due to dyslipidemia. The formula uses Gynostemma pentaphyllum, Chrysanthemum indicum, Chrysanthemum morifolium, Taraxacum mongolicum, Gardenia jasminoides, Anemarrhena asphodeloides, Prunus mume, Citrus medica, Bupleurum chinense, Alisma plantago-aquatica, Trichosanthes kirilowii peel, Atractylodes macrocephala, Poria cocos, Citrus reticulata peel, Magnolia officinalis, Poria cocos sclerotium, Cicadae periostracum, and Schisandra chinensis as adjuvants. Gynostemma pentaphyllum invigorates qi and strengthens the spleen, resolves phlegm and lowers lipids. Chrysanthemum indicum, Chrysanthemum morifolium, Taraxacum mongolicum, Gardenia jasminoides, and Anemarrhena asphodeloides clear heat and purge fire, detoxify and moisten dryness, clear liver fire and clear damp heat. It is indicated for symptoms such as yang hyperactivity transforming into heat, impaired glucose tolerance with dryness and heat damaging body fluids, and dyslipidemia with damp heat accumulation. Prunus mume, Citrus medica, and Bupleurum chinense soothe the liver and relieve stagnation. This formula addresses the root causes of emotional imbalance and liver qi stagnation in modern populations, while also acknowledging spleen and stomach disharmony due to phlegm-dampness retention. It includes Alisma plantago-aquatica, Trichosanthes kirilowii peel, Atractylodes macrocephala, Poria cocos, Citrus reticulata peel, and Magnolia officinalis to strengthen the spleen, dispel dampness, regulate qi, and resolve phlegm, addressing the accompanying symptoms of metabolic syndrome with phlegm-dampness obstruction, improving limb heaviness, abdominal distension, and loose stools. Poria cocos and Cicadae periostracum calm the mind and soothe the nerves, dispersing wind-heat and relieving insomnia, excessive dreaming, and blurred vision. Schisandra chinensis astringes and consolidates, replenishes qi and generates fluids, both consolidating yin fluids to prevent dissipation and assisting spleen function in replenishing the body's resources. Germinated barley, malt, and Amomum villosum serve as adjuvants. Germinated barley and malt promote digestion, strengthen the spleen and stomach, preventing the cloying nature of tonifying herbs from hindering stomach function, and ensuring the spleen and stomach's digestive function. Amomum villosum resolves dampness, stimulates appetite, warms the spleen, and stops diarrhea, both aiding in the removal of dampness and harmonizing the properties of other herbs.

[0186] This formula is well-balanced, addressing both the root cause and symptoms, organically combining medicinal and edible herbs with potent medicinal properties. The entire formula nourishes without causing stagnation, moisturizes without being cloying, clears without harming the body's vital energy, and unblocks without damaging Yin. It addresses the complex pathogenesis of metabolic syndrome, characterized by "deficiency of the root and excess of the branch, multiple organ involvement, and phlegm and blood stasis" (spleen, kidney, liver, and kidney deficiency; Yang excess; blood stasis; phlegm and dampness; dryness and heat; and liver stagnation), providing holistic conditioning. It is especially suitable for modern individuals suffering from hypertension, impaired glucose tolerance, and dyslipidemia due to excessive stress, emotional imbalance, lack of sleep, and irregular diet. It covers primary hypertension, impaired glucose tolerance, dyslipidemia, and early-stage metabolic syndrome conditioning.

[0187] In addition, this formula incorporates the academic ideas of Xin'an medicine, which emphasizes "holistic conditioning, addressing both the root cause and symptoms, and the principle of food and medicine sharing the same origin." While stabilizing blood pressure, controlling blood sugar, and regulating blood lipids, it can also significantly improve accompanying symptoms such as dizziness, headache, fatigue, dry mouth and excessive thirst, heaviness in the limbs, irritability, insomnia, abdominal distension, and loose stools. The formula is effective and has no toxic side effects.

[0188] As a preferred embodiment of the present invention, the herbal plaster for strengthening the body and promoting blood circulation is prepared from the following herbal raw materials by weight:

[0189] Calcined dragon bone 250g, calcined oyster shell 250g, Sichuan lovage rhizome 100g, Gynostemma pentaphyllum 300g, Alisma plantago-aquatica 180g, Pueraria lobata root 300g, Salvia miltiorrhiza 200g, Trichosanthes kirilowii peel 250g, wild chrysanthemum 200g, Poria cocos 180g, Astragalus membranaceus 180g, earthworm 100g, Bupleurum chinense 150g, Gastrodia elata 250g, Uncaria rhynchophylla 120g, green plum blossom 160g, Citrus medica 180g, stone Dendrobium 180g, Anemarrhena 180g, Schisandra chinensis 120g, Ligustrum lucidum 180g, Gardenia jasminoides 180g, Cicadae periostracum 200g, Trionyx sinensis 250g, Tortoise shell glue 60g, Germinated barley 180g, Germinated wheat 180g, Dioscorea opposita 300g, Amomum villosum 30g, Atractylodes macrocephala 180g, Citrus reticulata peel 150g, Taraxacum mongolicum 300g, Chrysanthemum morifolium 180g, Magnolia officinalis 180g, Poria cocos 180g.

[0190] Calcined dragon bone, calcined oyster shell, and turtle shell are soaked in water and then decocted. Then, pre-soaked herbs such as chuanxiong, gynostemma pentaphyllum, alisma plantago-aquatica, kudzu root, salvia miltiorrhiza, trichosanthes peel, wild chrysanthemum, poria cocos, astragalus membranaceus, earthworm, bupleurum chinense, gastrodia elata, uncaria rhynchophylla, green plum blossom, citronella cirrhosa, dendrobium nobile, anemarrhena asphodeloides, schisandra chinensis, privet fruit, gardenia, cicada slough, germinated rice, malt, yam, atractylodes macrocephala, tangerine peel, dandelion, chrysanthemum, magnolia officinalis, and poria cocos are added. The mixture is brought to a boil over high heat, then simmered over low heat for a period of time. Then, amomum villosum is added and decocted for another period of time. The dregs are separated and decocted again. The two decoctions are combined, filtered, heated, and concentrated. Melted tortoise shell glue is added, along with an appropriate amount of xylitol. The mixture is then simmered until it reaches a thick paste consistency, yielding a tonic paste for treating hypertension, impaired glucose tolerance, and dyslipidemia.

[0191] This invention presents a traditional Chinese medicine plaster formula for strengthening the body and promoting blood circulation, composed of the following herbs: calcined dragon bone, calcined oyster shell, chuanxiong rhizome, gynostemma pentaphyllum, alisma rhizome, kudzu root, salvia root, trichosanthes peel, wild chrysanthemum, poria cocos, astragalus root, earthworm, bupleurum root, gastrodia rhizome, uncaria rhizome, green plum blossom, citron, dendrobium, anemarrhena rhizome, schisandra fruit, privet fruit, gardenia fruit, cicada slough, turtle shell, tortoise shell glue, germinated rice, malt, yam, amomum fruit, atractylodes rhizome, tangerine peel, dandelion, chrysanthemum, magnolia bark, and poria cocos. The combination of herbs in this formula reflects the local characteristics of Xin'an medicine and is particularly beneficial in improving hypertension, impaired glucose tolerance, and dyslipidemia, with definite efficacy and no toxic side effects. Detailed Implementation

[0192] The present invention will be further described in detail below with reference to embodiments.

[0193] Example 1

[0194] Preparation of Gubentongmai Ointment for treating hypertension, impaired glucose tolerance, and dyslipidemia:

[0195] Compound composition: 250g calcined dragon bone, 250g calcined oyster shell, 100g chuanxiong rhizome, 300g gynostemma pentaphyllum, 180g alisma rhizome, 300g kudzu root, 200g salvia miltiorrhiza root, 250g trichosanthes peel, 200g wild chrysanthemum, 180g poria cocos, 180g astragalus root, 100g earthworm, 150g bupleurum root, 250g gastrodia rhizome, 120g uncaria rhizome, 160g green plum blossom, 180g citron. Dendrobium 180g, Anemarrhena 180g, Schisandra 120g, Ligustrum lucidum 180g, Gardenia 180g, Cicada slough 200g, Turtle shell 250g, Tortoise shell glue 60g, Germinated barley 180g, Germinated wheat 180g, Dioscorea opposita 300g, Amomum villosum 30g, Atractylodes macrocephala 180g, Tangerine peel 150g, Dandelion 300g, Chrysanthemum 180g, Magnolia officinalis 180g, Poria cocos 180g.

[0196] Take one portion of the above formula. Place the hard shelled medicinal materials (calcined dragon bone, calcined oyster shell, turtle shell) in a container and soak in cold water for 30 minutes. Then decoct for 30 minutes. Afterward, add the following herbs that have been soaked in cold water for 30 minutes: Ligusticum chuanxiong, Gynostemma pentaphyllum, Alisma plantago-aquatica, Pueraria lobata, Salvia miltiorrhiza, Trichosanthes kirilowii peel, Chrysanthemum indicum, Poria cocos, Astragalus membranaceus, Pheretima aspergillum, Bupleurum chinense, Gastrodia elata, Uncaria rhynchophylla, Prunus mume, Citrus medica, Dendrobium nobile, Anemarrhena asphodeloides, Schisandra chinensis, Ligustrum lucidum, Gardenia jasminoides, Cicadae periostracum, Germinated barley, Germinated wheat, Dioscorea opposita, Atractylodes macrocephala, Citrus reticulata peel, Taraxacum mongolicum, Chrysanthemum morifolium, Magnolia officinalis, and Poria cocos. Add water to cover the herbs. Add 10-15 cm of water to the pot, bring to a boil over high heat, then simmer over low heat for 1.5 hours. Add the cardamom to the pot and continue simmering for 5-10 minutes. Filter the liquid. Add cold water to the dregs, 10-15 cm above the liquid level, and simmer for 1 hour. Filter the second decoction. Combine the two decoctions, let them settle, and then filter through four layers of gauze to obtain a clear liquid. Place the filtrate in a pot and concentrate it over low heat. At the same time, add melted tortoise shell glue and 120g of xylitol. Stir constantly to prevent sticking to the bottom and cook until it becomes a thick paste. While hot, put it into jars, and after cooling, seal and refrigerate to obtain the Gubentongmai Paste.

[0197] Example 2

[0198] This invention included 20 patients diagnosed with hypertension, impaired glucose tolerance, and dyslipidemia at the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine between 2024 and 2025 (as shown in Table 2). These patients received Gubentongmai ointment (prepared according to the method in Example 1), taken twice daily (one spoonful each at noon and before bedtime), for 10 days as one course of treatment, for a total of three courses. The study observed the efficacy of the treatment by examining changes in the patients' TCM symptom and sign scores, blood pressure, fasting and 2-hour postprandial blood glucose levels, and blood lipids before and after treatment with this ointment.

[0199] 1. The Traditional Chinese Medicine (TCM) Symptom and Sign Scoring Scale adopts a subjective assessment method, and is formulated with reference to the relevant content of the "Guiding Principles for Clinical Research on New Traditional Chinese Medicine Treatment" (Table 1). Subjects are required to score each item according to their own situation, and the scores of all items are finally added together to obtain the total score. Symptoms and signs are divided into four levels: normal, mild, moderate, and severe. For primary symptoms and signs, normal is 0 points, mild is 2 points, moderate is 4 points, and severe is 6 points. For secondary symptoms and signs, normal is 0 points, mild is 1 point, moderate is 2 points, and severe is 3 points. Records are made before and after treatment, and the total scores of symptoms and signs are calculated separately before and after treatment. The efficacy of the two groups is observed.

[0200] The specific operating steps are as follows:

[0201] (1) Explain the principle of the TCM syndrome scoring scale to the patient, provide the same test information to each patient, and the patient should carefully read and sign the informed consent form. The test subject should choose the answer option that best suits his or her own situation based on his or her actual situation.

[0202] (2) After the test taker finishes answering the questions, the medical staff or trained personnel shall calculate and record the score and inform the test taker of the result.

[0203] Table 1. Traditional Chinese Medicine Symptom and Sign Scoring Table

[0204] Name: Gender: Age: Hospital Number: Assessment Time:

[0205] Symptoms and signs Scoring Criteria Score Dry mouth and excessive thirst No dry mouth or throat 0 points Dry mouth and throat, no desire to drink water 2 points Dry mouth and throat, wanting to drink water 4 points Dry mouth and throat, increased water intake 6 points dizziness No dizziness or vertigo 0 points Dizziness and blurred vision, occurring intermittently. 2 points Vision of rotation, unable to walk 4 points Dizziness and throbbing, unable to stand 6 points Lower back and knee pain No lower back or knee pain 0 points Legs are too weak to stand for long 2 points Persistent lower back and knee pain, but able to perform daily activities 4 points Lower back and knee pain, prefers to lie down 6 points Blurred vision Ignoring blur 0 points There is a small dark shadow in front of me 2 points Multiple small black shadows in front of my eyes, causing mild visual distortion. 4 points Large dark shadows in front of the eyes or severe visual distortion 6 points numbness of limbs No limb numbness 0 points Occasionally numb 2 points Numbness intermittent 4 points Persistent occurrence, apathy 6 points Fatigue and forgetfulness listlessness, fatigue, and forgetfulness 0 points Feeling listless and occasionally forgetful 1 point Feeling mentally fatigued, sleepy, and sometimes forgetful. 2 points Extreme mental fatigue, forgetfulness in an instant 3 points Tinnitus and hearing loss No tinnitus or hearing loss 0 points Occasionally I experience tinnitus and hearing loss of 10-30 dB. 1 point Tinnitus was relieved, and hearing loss was reduced by 31-60 dB. 2 points The tinnitus is severe, and the hearing loss is more than 61 dB. 3 points Night sweats No night sweats 0 points Sweating is mainly on the head, with occasional occurrences. 1 point Damp chest and back 2 points The body is damp as if it has been washed with water, and this often occurs. 3 points Insomnia No insomnia 0 points Sleep decreased slightly 1 point I often suffer from insomnia 2 points Unable to fall asleep 3 points Five-center heat No five-center heat 0 points Hot palms and soles at night 1 point Irritability and burning sensation in the palms and soles 2 points Feeling hot and not wanting to wear clothes or blankets 3 points constipate No constipation 0 points Constipated stool, one bowel movement per day 1 point Constipation, bowel movement every two days 2 points Difficulty defecating, once every few days 3 points

[0206] 2. 24-hour ambulatory blood pressure monitoring (24hABPM) uses an objective, continuous measurement method. Subjects wear an ambulatory blood pressure recorder, which automatically measures blood pressure at set intervals during daily activities and sleep. The system then aggregates the blood pressure data throughout the day, including daytime and nighttime readings, to obtain the average blood pressure, workload, and circadian rhythm. Based on different levels of the monitored indicators, blood pressure status can be categorized as normal blood pressure, high-normal blood pressure, grade 1 hypertension, grade 2 hypertension, and grade 3 hypertension, and the circadian rhythm type can also be determined.

[0207] 3. Fasting and 2-hour postprandial blood glucose measurements are performed using an objective assessment method. Strict adherence to timing, dietary guidelines, and operational procedures is required for both measurements. Fasting blood glucose should be collected first: fasting for at least 8-12 hours is required, with a small amount of water allowed. Collect venous blood or finger prick blood in the morning in a quiet state, avoiding strenuous exercise, smoking, and emotional excitement. Next, 2-hour postprandial blood glucose measurement should be performed: timing should begin from the first bite of food, with blood collected strictly at the full 2-hour mark. Consume a normal daily meal, without deliberately adding extra meals or dieting. During this period, refrain from eating, drinking large amounts of water, or engaging in strenuous exercise. The blood collection procedure and instrument usage are the same as for fasting. Record the values ​​promptly and label the testing time and status to ensure accurate and comparable results.

[0208] 4. Blood lipid testing uses an objective assessment method. When collecting blood samples for blood lipid testing, fasting for more than 12 hours is generally required (a small amount of plain water can be consumed, but tea, coffee, beverages, and food are prohibited). Avoid strenuous exercise, alcohol consumption, and high-fat diets for 24 hours before blood collection. Discontinue any medications that may affect blood lipids (if necessary, this should be noted on the test report). After the patient has rested quietly in a seated position for 5-10 minutes, blood is collected via vein. The blood should be sent for testing promptly after collection to ensure accurate test results.

[0209] 5. Statistical Results

[0210] Table 2. Case information and statistical results before and after treatment.

[0211] Serial Number Name Average blood pressure (before) Average blood pressure (after) Fasting blood glucose (before) Fasting blood glucose (post-fasting) 2-hour postprandial blood glucose (before) 2-hour postprandial blood glucose Total cholesterol (before) Total cholesterol (after) Triglycerides (front) Triglycerides (post-coital) Low-density lipoprotein cholesterol (before) Low-density lipoprotein cholesterol (LDL-C) Syndrome score (before) Syndrome Indication (Later) 1 open** 158 / 96 128 / 82 6.3 5.2 8.5 6.8 6.8 5.2 3.5 2.1 2.4 1.9 18 7 2 plum** 152 / 94 126 / 80 6.5 5.4 9.2 7.0 6.5 4.9 3.2 1.9 2.3 1.8 17 6 3 king** 162 / 98 132 / 84 5.9 5.1 7.6 6.5 7.2 5.4 4.1 2.3 2.8 2.0 20 9 4 Zhao* 148 / 92 124 / 78 6.7 5.3 10.1 6.9 6.2 4.7 2.9 1.7 2.5 1.9 16 5 5 List** 156 / 95 130 / 82 6.2 5.0 8.8 6.6 6.9 5.1 3.6 2.0 2.2 1.7 19 8 6 Liu** 150 / 93 125 / 80 5.7 4.9 7.4 6.4 6.3 4.8 3.0 1.8 3.0 2.1 17 6 7 week** 160 / 97 131 / 83 6.6 5.2 9.5 6.7 7.0 5.3 3.8 2.2 2.4 1.8 19 8 8 Wu** 154 / 94 127 / 81 6.4 5.5 8.3 7.1 6.6 5.0 3.3 1.9 2.3 1.9 18 7 9 Zheng* 149 / 92 124 / 79 6.8 5.3 10.5 6.8 6.1 4.6 2.8 1.6 3.1 2.0 15 5 10 Sun** 157 / 96 129 / 82 6.1 5.1 7.9 6.5 6.8 5.2 3.5 2.1 2.5 1.7 18 7 11 Zhu** 153 / 93 126 / 80 5.8 4.8 7.7 6.3 6.4 4.8 3.1 1.8 2.1 1.6 16 6 12 Xu** 161 / 98 133 / 85 6.5 5.4 9.0 7.0 7.1 5.4 4.0 2.3 3.3 2.1 20 9 13 Hu** 151 / 92 125 / 79 6.3 5.2 8.6 6.6 6.2 4.7 2.9 1.7 2.4 1.8 16 5 14 Guo** 159 / 97 130 / 83 6.9 5.6 10.8 7.2 6.9 5.2 3.7 2.1 2.2 1.7 19 8 15 Forest** 155 / 95 128 / 81 6.0 5.0 7.5 6.4 6.7 5.0 3.4 2.0 3.4 2.0 18 7 16 yellow** 147 / 91 123 / 78 6.4 5.3 8.9 6.9 6.0 4.5 2.7 1.5 2.5 1.9 15 4 17 horse** 158 / 96 129 / 82 6.2 5.1 8.2 6.7 6.8 5.2 3.6 2.1 2.3 1.8 19 8 18 high** 152 / 93 126 / 80 6.6 5.4 9.7 7.1 6.5 4.9 3.2 1.9 2.4 1.7 17 6 19 Luo** 163 / 99 134 / 86 6.3 5.2 8.4 6.8 7.3 5.5 4.2 2.4 2.2 1.6 21 10 20 Cai** 150 / 92 124 / 79 6.5 5.3 9.3 6.9 6.1 4.6 2.8 1.6 2.5 1.9 16 5

[0212] Note: The units for each indicator in Table 2 are as follows:

[0213] Average blood pressure: mmHg; fasting blood glucose: mmol / L; 2-hour postprandial blood glucose: mmol / L; total cholesterol: mmol / L; triglycerides: mmol / L; low-density lipoprotein cholesterol: mmol / L.

[0214] As shown in Table 2, compared with before treatment, the patients' blood pressure decreased (P<0.05), fasting blood glucose decreased (P<0.05), 2-hour postprandial blood glucose decreased (P<0.05), cholesterol decreased (P<0.05), triglycerides decreased (P<0.05), low-density lipoprotein cholesterol decreased (P<0.05), and the TCM symptom and sign score decreased (P<0.05) after treatment.

[0215] Therefore, this invention provides an effective treatment for the clinical treatment of hypertension, impaired glucose tolerance, and dyslipidemia, a difficult-to-treat comorbidity, and has broad prospects for clinical application.

Claims

1. A traditional Chinese medicine plaster for treating hypertension, impaired glucose tolerance, and dyslipidemia, characterized in that, It is made from the following Chinese medicinal materials by weight: Calcined dragon bone 240-260g, calcined oyster shell 240-260g, Sichuan lovage rhizome 90-110g, Gynostemma pentaphyllum 290-310g, Alisma plantago-aquatica 170-190g, Pueraria lobata root 290-310g, Salvia miltiorrhiza root 190-210g, Trichosanthes kirilowii peel 240-260g, Chrysanthemum indicum 190-210g, Poria cocos 170-190g, Astragalus membranaceus root 170-190g, Pheretima aspergillum 90-110g, Bupleurum chinense root 140-160g, Gastrodia elata rhizome 240-260g, Uncaria rhynchophylla rhizome 110-130g, Prunus mume flower 150-170g, Citrus medica fruit 170-190g, Dendrobium nobile 170-190g, Anemarrhena asphodeloides 170-190g, Schisandra chinensis 110-130g, Ligustrum lucidum 170-190g, Gardenia jasminoides 170-190g, Cicadae periostracum 190-210g, Trionyx sinensis 240-260g, Tortoise shell glue 50-70g, Germinated barley 170-190g, Germinated wheat 170-190g, Dioscorea opposita 290-310g, Amomum villosum 30g, Atractylodes macrocephala 170-190g, Citrus reticulata 140-160g, Taraxacum mongolicum 290-310g, Chrysanthemum morifolium 170-190g, Magnolia officinalis 170-190g, Poria cocos 170-190g.

2. The herbal paste for strengthening the body and promoting blood circulation as described in claim 1, characterized in that, It is made from the following Chinese medicinal materials by weight: Calcined dragon bone 250g, calcined oyster shell 250g, Sichuan lovage rhizome 100g, Gynostemma pentaphyllum 300g, Alisma plantago-aquatica 180g, Pueraria lobata root 300g, Salvia miltiorrhiza 200g, Trichosanthes kirilowii peel 250g, wild chrysanthemum 200g, Poria cocos 180g, Astragalus membranaceus 180g, earthworm 100g, Bupleurum chinense 150g, Gastrodia elata 250g, Uncaria rhynchophylla 120g, green plum blossom 160g, Citrus medica 180g, stone Dendrobium 180g, Anemarrhena 180g, Schisandra chinensis 120g, Ligustrum lucidum 180g, Gardenia jasminoides 180g, Cicadae periostracum 200g, Trionyx sinensis 250g, Tortoise shell glue 60g, Germinated barley 180g, Germinated wheat 180g, Dioscorea opposita 300g, Amomum villosum 30g, Atractylodes macrocephala 180g, Citrus reticulata peel 150g, Taraxacum mongolicum 300g, Chrysanthemum morifolium 180g, Magnolia officinalis 180g, Poria cocos 180g.

3. A method for preparing the herbal paste for strengthening the body and promoting blood circulation as described in claim 1 or 2, characterized in that, Calcined dragon bone, calcined oyster shell, and turtle shell are soaked in water and decocted for a period of time. Then, pre-soaked herbs such as chuanxiong, gynostemma pentaphyllum, alisma plantago-aquatica, kudzu root, salvia miltiorrhiza, trichosanthes peel, wild chrysanthemum, poria cocos, astragalus membranaceus, earthworm, bupleurum chinense, gastrodia elata, uncaria rhynchophylla, green plum blossom, citron, dendrobium nobile, anemarrhena asphodeloides, schisandra chinensis, privet fruit, gardenia, cicada slough, germinated rice, malt, yam, atractylodes macrocephala, tangerine peel, dandelion, chrysanthemum, magnolia officinalis, and poria cocos are added. After boiling over high heat, the mixture is simmered over low heat for a period of time. Then, amomum villosum is added and decocted for another period of time. After separating the herbs, the dregs are decocted again with water. The two decoctions are combined, filtered, heated and concentrated, and melted tortoise shell glue is added. An appropriate amount of xylitol is added and the mixture is simmered until it reaches a thick paste state. This produces a paste for treating hypertension, impaired glucose tolerance, and dyslipidemia.