A composition with improved sleep quality function and a preparation method thereof

Abstract

The present application relates to a composition with improved sleep quality function and its preparation method, belonging to the technical field of cosmetics and external preparation. The composition comprises: gamma-aminobutyric acid, isosorbide dimethyl ether, plant extract compound (pink passion fruit, jujube kernel, polygala, rehmannia), aromatic essential oil (lavender oil, dalbergia odorifera oil, linaloe extract), menthol, polyacryl dimethyl ammonium taurate and moisturizing and preservative system. By using isosorbide dimethyl ether and gamma-aminobutyric acid to form a penetration precursor solution, the problem of transdermal difficulty of gamma-aminobutyric acid is solved; and through a specific preparation process, a gradient sleep-aiding release based on the volatility difference of essential oil and gel wrapping is constructed, realizing the phased sleep-aiding effect of instant cooling to block irritability, induction of relaxation synergistic effect, and whole night slow release to maintain deep sleep. The composition has high transdermal absorption rate, controllable aroma release timing, long-lasting sleep-aiding effect, and good application prospect.

Description

Technical Field

[0001] This invention belongs to the field of cosmetics and topical preparations technology, and relates to a composition with the function of improving sleep quality and its preparation method. Background Technology

[0002] With the fast pace of modern life and rising mental stress, insomnia and poor sleep quality have become prevalent sub-health conditions, creating a market demand for various sleep aids. Currently, the market offers a wide variety of sleep aids, mainly consisting of oral health supplements, sedative-hypnotic drugs, and aromatherapy products.

[0003] Oral sleep aids are currently the mainstream choice, but they face numerous insurmountable technical limitations. Gamma-aminobutyric acid (GABA), a key inhibitory neurotransmitter in the mammalian central nervous system, possesses clear sedative, anti-anxiety, and sleep-inducing effects. However, it is a highly polar macromolecule with low bioavailability after oral administration. Furthermore, it undergoes first-pass absorption in the gastrointestinal tract and metabolism in the liver, resulting in the breakdown and loss of a large amount of active ingredients. Simultaneously, long-term oral use of these sleep aids may lead to dependence on certain components, and sudden discontinuation can easily cause rebound insomnia, emotional distress, and other withdrawal symptoms.

[0004] While traditional topical sleep aids and aromatherapy products avoid the metabolic risks associated with oral medications, they still have significant technological limitations. These products often rely on the evaporation of a single essential oil or simple plant extracts for their soothing effect. The release rate of the fragrance is difficult to control, often dissipating rapidly after application or burning, failing to achieve a long-lasting soothing effect and hindering the maintenance of deep sleep throughout the night. They either act too quickly and have a short duration, or the strong, pungent odor interferes with falling asleep, failing to achieve a synergistic and lasting sleep improvement effect. Furthermore, conventional topical sleep aids are not optimized for transdermal absorption of active ingredients; water-soluble calming ingredients struggle to penetrate the stratum corneum and can only exert a weak effect through the olfactory pathway. Summary of the Invention

[0005] The purpose of this invention is to provide a composition with the function of improving sleep quality and its preparation method. Through the synergistic design of transdermal penetration, aroma gradient release and film-forming sustained release, it achieves a continuous sleep-aiding effect from the moment of application to the whole night after falling asleep.

[0006] The objective of this invention can be achieved through the following technical solutions:

[0007] A composition having the function of improving sleep quality, comprising the following components by weight percentage:

[0008] 5-10% Butanediol;

[0009] 3-7% glycerin;

[0010] 0.5-1.5% γ-aminobutyric acid;

[0011] 0.5-3% plant extract compound, said compound comprising pink passion fruit extract, jujube seed extract, polygala extract and rehmannia extract;

[0012] 0.5-2% aromatic essential oil, wherein the aromatic essential oil comprises lavender oil, sandalwood oil and agarwood extract;

[0013] 0.05-0.5% Menthol;

[0014] 0.1-1% thickener, selected from ammonium polyacrylamide dimethyl taurate;

[0015] 1-5% skin conditioning agent containing isosorbide dimethyl ether;

[0016] 0.1-1% p-hydroxyacetophenone;

[0017] 0.1-1% 1,2-Hexanediol;

[0018] The rest is deionized water;

[0019] The weight ratio of isosorbide dimethyl ether to γ-aminobutyric acid is 2:1 to 10:1.

[0020] As a preferred embodiment of the present invention, the weight ratio of pink passion fruit extract, jujube seed extract, polygala extract and rehmannia extract in the plant extract compound is 1:1:1:1.

[0021] As a preferred embodiment of the present invention, the weight ratio of lavender oil, sandalwood oil and agarwood extract in the aromatic essential oil is (3-5):(1-2):(0.5-1).

[0022] Furthermore, the method for preparing the topical composition with the function of improving sleep quality includes the following steps:

[0023] (1) Add γ-aminobutyric acid to a mixture of isosorbide dimethyl ether and part of butanediol, heat to 40-50℃ and stir until completely clear to obtain a permeation precursor solution;

[0024] (2) Add polyacrylamide dimethyl taurate ammonium slowly to deionized water and shear until it is completely swollen to form a transparent gel substrate;

[0025] (3) Add the permeation precursor solution obtained in step (1) to the gel substrate in step (2) and mix well;

[0026] (4) Add p-hydroxyacetophenone to the remaining butanediol, heat to 75-85℃ and stir until completely dissolved, add to the system of step (3), mix evenly, and then add 1,2-hexanediol;

[0027] (5) When the system temperature drops below 35°C, lavender oil, sandalwood oil, agarwood extract and menthol are premixed to form an oil phase, and then added dropwise to the system in step (4) under shear conditions to emulsify and disperse.

[0028] (6) Pre-dissolve pink passion fruit extract, jujube seed extract, polygala extract and prepared rehmannia extract in glycerin, add to the system of step (5), and stir evenly;

[0029] (7) Adjust the pH value to 5.0-6.0, let it stand to defoam, and you will get the product.

[0030] In this application, γ-aminobutyric acid (GABA) is a major inhibitory neurotransmitter in the mammalian central nervous system, exerting sedative and anti-anxiety effects. Although its molecular weight is small, it is highly polar and has difficulty penetrating the lipid bilayer of the stratum corneum. Isosorbide dimethyl ether, as a novel green penetration enhancer, has an amphiphilic isosorbide backbone in its molecular structure, which can reversibly insert into the lipid bilayer of the stratum corneum, disrupting the orderly arrangement of lipids and increasing lipid fluidity. In step (1), it is premixed with isosorbide dimethyl ether as a carrier, which improves the penetration of GABA.

[0031] Based on the differences in volatility of different essential oils, an aromatic essential oil composed of lavender oil (medium volatility), sandalwood oil (low volatility), and agarwood extract (high volatility) was designed. Agarwood extract is rich in volatile chromones and sesquiterpenes, which are rapidly released upon application. It acts directly on the amygdala (emotional center) and hippocampus (memory center) through the olfactory epithelium of the nasal cavity, quickly blocking the transmission of daytime irritability signals and inducing emotional calm. The instantaneous cooling sensation of menthol is activated through cold receptors, causing a shift in attention and helping users escape from anxious thoughts. At very low doses (0.05-0.5%), its cooling sensation subsides within 2-5 minutes, avoiding interference with sleep. Lavender oil's main components, linalool and linalyl acetate, have clear sedative-hypnotic effects, producing a synergistic effect of olfaction and skin absorption with transdermal γ-aminobutyric acid. Sandalwood oil's main components are α-santalol and β-santalol, with low volatility and a large molecular weight. Physically blocked within the breathable membrane formed by ammonium polyacrylamide dimethyl taurate, the release rate is slow, thus exerting a lasting effect on stabilizing mood and helping to maintain deep sleep.

[0032] Meanwhile, the non-volatile active ingredients in Rehmannia glutinosa and Polygala tenuifolia extracts continue to work under the gel film, preventing you from waking up at night due to dry skin or loss of fragrance.

[0033] As a preferred technical solution of the present invention, the shearing speed in step (2) is 2000-3000 rpm and the time is 5-10 minutes.

[0034] As a preferred technical solution of the present invention, the shearing speed in step (4) is 1000-1500 rpm and the time is 2-5 minutes.

[0035] As a preferred technical solution of the present invention, the stirring speed in step (5) is 100-300 rpm.

[0036] As a preferred technical solution of the present invention, the standing defoaming time in step (6) is 12-24 hours, so that the gel network can be rearranged and stably encapsulated with low volatile essential oil components.

[0037] As a preferred embodiment of the present invention, the composition is a gel, cream, serum, or mask preparation.

[0038] As a preferred embodiment of the present invention, the jujube seed extract and polygala extract are obtained by supercritical CO2 extraction or ethanol reflux extraction.

[0039] The beneficial effects of this invention are:

[0040] (1) This invention introduces isosorbide dimethyl ether as a penetration enhancer, and in preparation step (1), it is premixed with γ-aminobutyric acid at 40-50℃ to form a homogeneous penetration precursor solution. The isosorbide skeleton in the isosorbide dimethyl ether molecule is amphiphilic, which can reversibly insert into and disrupt the orderly arrangement of lipids in the stratum corneum, increase lipid fluidity, thereby carrying γ-aminobutyric acid molecules to penetrate the skin barrier efficiently, improve the transdermal absorption rate of GABA, and solve the problems of low bioavailability and ineffective topical application of γ-aminobutyric acid.

[0041] (2) Based on the differences in volatility of different essential oils and their olfactory pathway mechanisms, this invention designs an aromatic system composed of agarwood extract (high volatility component), lavender oil (medium volatility component), and sandalwood oil (low volatility component) in a specific ratio of (3-5):(1-2):(0.5-1). Combined with the physical blocking effect of the film-forming polymer polyacrylamide dimethyl taurate, this invention achieves gradient release and sustained effect of the topical sleep aid product. The immediate phase is the highly volatile agarwood extract combined with a low dose of menthol; the medium volatile essential oil is lavender oil, which synergistically promotes sleep by penetrating γ-aminobutyric acid through the skin; the sustained-release phase is the breathable membrane formed after drying polyacrylamide dimethyl taurate, which physically blocks the low volatility sandalwood oil. Combined with the non-volatile active ingredients in Rehmannia glutinosa and Polygala tenuifolia extracts, the active ingredients continue to act under the membrane, preventing nighttime awakening due to fragrance dissipation or skin dryness.

[0042] (3) This invention combines modern neurotransmitter theory with traditional Chinese medicine theory. Gamma-aminobutyric acid can rapidly inhibit nerve excitation; pink passion fruit extract, jujube seed extract, polygala extract and prepared rehmannia extract are compounded in a ratio of 1:1:1:1. After being absorbed through the skin, they regulate the balance of the autonomic nervous system and nourish the heart and kidneys. This not only solves the acute symptoms of difficulty falling asleep, but also improves the chronic physical problems of shallow sleep and easy early awakening. Detailed Implementation

[0043] To further illustrate the technical means and effects of the present invention in achieving its intended purpose, the following detailed description of the specific implementation methods, structures, features, and effects of the present invention, in conjunction with embodiments, is provided below.

[0044] Example 1

[0045] A transparent gel composition with sleep quality improvement function

[0046] 1. Components:

[0047] γ-Aminobutyric acid 1%;

[0048] 5% isosorbide dimethyl ether;

[0049] Butanediol 5%;

[0050] Ammonium polyacrylamide dimethyl taurate 0.5%;

[0051] 5% glycerin;

[0052] Plant extract compound 3% (pink passionflower fruit extract: jujube seed extract (supercritical CO2 extraction): polygala extract (supercritical CO2 extraction): rehmannia extract = 1:1:1:1);

[0053] Aromatic essential oil 1.6% (lavender oil: sandalwood oil: agarwood extract = 5:2:1);

[0054] Menthol 0.1%;

[0055] p-Hydroxyacetophenone 0.4%;

[0056] 1,2-Hexanediol 0.4%;

[0057] Adjust the pH to 5.5 with appropriate amounts of citric acid / sodium citrate;

[0058] Deionized water balance.

[0059] 2. Preparation method

[0060] In this embodiment, a transparent gel composition with a total mass of 1000g was prepared. The specific steps are as follows:

[0061] (1) Weigh 10.0g of γ-aminobutyric acid, add it to a mixture of 50.0g of isosorbide dimethyl ether and 20.0g of butanediol, place it in a water bath and heat it to 45°C. Stir at 300 rpm for 15 minutes until the solution is completely clear and transparent to obtain the osmosis precursor solution.

[0062] (2) Add 785g of deionized water to a clean main emulsifying pot, turn on the stirring at 50 rpm, slowly sprinkle in 5.0g of polyacrylamide dimethyl taurate ammonium powder to prevent clumping, turn on the high-speed shear emulsifier, set the speed to 2500 rpm, shear for 8 minutes until a transparent gel base is formed.

[0063] (3) Reduce the speed of the main pot to 400 rpm, slowly pour the permeation precursor solution obtained in step (1) into the gel base in step (2), and continue stirring for 5 minutes until the system is completely homogeneous.

[0064] (4) Weigh 4.0g of p-hydroxyacetophenone and add it to 15.0g of butanediol. Heat to 78°C and stir until completely dissolved to obtain a clear premixed preservative solution. Maintain the temperature of the main pot at 78°C and slowly add the premixed preservative solution to the system in step (3) while stirring at 200 rpm. Mix evenly. Then add 4.0g of 1,2-hexanediol and continue stirring for 5 minutes.

[0065] (5) Stop heating and allow the system temperature to drop below 35°C. Mix 10.0g lavender oil, 4.0g sandalwood oil, 2.0g agarwood extract, and 1.0g menthol evenly to prepare the oil phase. While maintaining the shearing state of the main pot, adjust the speed to 1200 rpm and add the above oil phase dropwise into the main pot system (dropping time is 3 minutes). After the dropwise addition is complete, continue shearing for 3 minutes to ensure the essential oils are evenly dispersed.

[0066] (6) Dissolve 7.5g of pink passion fruit extract, 7.5g of jujube seed extract, 7.5g of polygala root extract, and 7.5g of prepared rehmannia root extract in 15.0g of glycerin to prepare a traditional Chinese medicine extract. Set the speed of the main pot to 200 rpm, add the above traditional Chinese medicine extract, then add the remaining 35.0g of glycerin and 15.0g of butylene glycol, and stir at low speed for 10 minutes until well mixed;

[0067] (7) Take a sample to test the pH value, adjust the pH value to 5.5, and let it stand at room temperature for 24 hours to defoam, thus obtaining the gel composition with the function of improving sleep quality.

[0068] Example 2

[0069] A highly permeable serum with sleep quality improvement function

[0070] 1. Components:

[0071] γ-Aminobutyric acid 1.5%;

[0072] Isosorbide dimethyl ether 3.0%;

[0073] Butanediol 8.0%;

[0074] Ammonium polyacrylamide dimethyl taurate 0.3%;

[0075] Glycerin 4.0%;

[0076] Plant extract compound 2.0% (pink passion fruit extract: jujube seed extract (supercritical CO2 extraction): polygala extract (supercritical CO2 extraction): rehmannia extract = 1:1:1:1);

[0077] Aromatic essential oil 1.0% (lavender oil: sandalwood oil: agarwood extract = 3:1:0.5);

[0078] Menthol 0.05%;

[0079] p-Hydroxyacetophenone 0.4%;

[0080] 1,2-Hexanediol 0.4%;

[0081] Adjust the pH to 5.5 with appropriate amounts of citric acid / sodium citrate;

[0082] Deionized water balance.

[0083] 2. Preparation method:

[0084] In this embodiment, an essence with a total mass of 1000g is prepared. The specific steps are as follows:

[0085] (1) Weigh 15.0g of γ-aminobutyric acid, add it to a mixture of 30.0g of isosorbide dimethyl ether and 30.0g of butanediol, place it in a water bath and heat it to 50°C. Stir at 300 rpm for 20 minutes until the solution is completely clear and transparent to obtain the osmosis precursor solution.

[0086] (2) Add 779.5g of deionized water to a clean main emulsifying pot, turn on the stirring at 50 rpm, slowly sprinkle in 3.0g of polyacrylamide dimethyl taurate ammonium powder to prevent clumping, turn on the high-speed shear emulsifier, set the speed to 3000 rpm, shear for 10 minutes until a transparent gel base is formed.

[0087] (3) Reduce the speed of the main pot to 400 rpm, slowly pour the permeation precursor solution obtained in step (1) into the gel base in step (2), and continue stirring for 5 minutes until the system is completely homogeneous.

[0088] (4) Weigh 4.0g of p-hydroxyacetophenone and add it to 15.0g of butanediol. Heat to 75°C and stir until completely dissolved to obtain a clear premixed preservative solution. Maintain the temperature of the main pot at 75°C and slowly add the premixed preservative solution to the system in step (3) while stirring at 200 rpm. Mix evenly. Then add 4.0g of 1,2-hexanediol and continue stirring for 5 minutes.

[0089] (5) Stop heating and start the cooling cycle to lower the system temperature to below 35°C. Mix 6.0g lavender oil, 2.0g sandalwood oil, 1.0g agarwood extract and 0.5g menthol evenly to prepare the oil phase. Keep the main pot in shear mode, adjust the speed to 1500 rpm, and add the above oil phase to the main pot system (the adding time is 3 minutes). After the adding is complete, continue shearing for 5 minutes to make the essential oil disperse evenly.

[0090] (6) Dissolve 5.0g of pink passion fruit extract, 5.0g of jujube seed extract, 5.0g of polygala root extract, and 5.0g of prepared rehmannia root extract in 10.0g of glycerin to prepare a traditional Chinese medicine extract. Set the speed of the main pot to 300 rpm, add the above traditional Chinese medicine extract, then add the remaining 30.0g of glycerin and 35.0g of butylene glycol, and stir at low speed for 10 minutes until well mixed;

[0091] (7) Take a sample to test the pH value, adjust the pH value to 5.5, and let it stand at room temperature for 12 hours to defoam, thus obtaining the essence composition with the function of improving sleep quality.

[0092] Example 3

[0093] A facial mask liquid with sleep quality improvement function

[0094] 1. Components:

[0095] γ-Aminobutyric acid 0.8%;

[0096] Isosorbide dimethyl ether 4.0%;

[0097] Butanediol 6.0%;

[0098] Ammonium polyacrylamide dimethyl taurate 0.8%;

[0099] Glycerin 6.0%;

[0100] Plant extract compound 3.0% (pink passionflower fruit extract: jujube seed extract (95% ethanol reflux extraction): polygala extract (95% ethanol reflux extraction): rehmannia extract = 1:1:1:1).

[0101] Aromatic essential oil 1.6% (lavender oil: sandalwood oil: agarwood extract = 5:2:1);

[0102] Menthol 0.2%;

[0103] p-Hydroxyacetophenone 0.5%;

[0104] 1,2-Hexanediol 0.5%;

[0105] Adjust the pH to 5.5 with appropriate amounts of citric acid / sodium citrate;

[0106] Deionized water balance.

[0107] 2. Preparation method

[0108] In this embodiment, a facial mask liquid with a total mass of 1000g is prepared. The specific steps are as follows:

[0109] (1) Weigh 8.0g of γ-aminobutyric acid, add it to a mixture of 40.0g of isosorbide dimethyl ether and 25.0g of butanediol, place it in a water bath and heat it to 45°C. Stir at 300 rpm for 15 minutes until the solution is completely clear and transparent to obtain the osmosis precursor solution.

[0110] (2) Add 771g of deionized water to a clean main emulsifying pot, turn on the stirring at 50 rpm, slowly sprinkle in 8.0g of polyacrylamide dimethyl taurate ammonium powder to prevent clumping, turn on the high-speed shear emulsifier, set the speed to 2500 rpm, shear for 8 minutes until a transparent gel base is formed.

[0111] (3) Reduce the speed of the main pot to 400 rpm, slowly pour the permeation precursor solution obtained in step (1) into the gel base in step (2), and continue stirring for 5 minutes until the system is completely homogeneous.

[0112] (4) Weigh 5.0g of p-hydroxyacetophenone and add it to 15.0g of butanediol. Heat to 80°C and stir until completely dissolved to obtain a clear premixed preservative solution. Maintain the temperature of the main pot at 80°C and slowly add the premixed preservative solution to the system in step (3) while stirring at 200 rpm. Mix evenly. Then add 5.0g of 1,2-hexanediol and continue stirring for 5 minutes.

[0113] (5) Stop heating and start the cooling cycle to lower the system temperature to below 35°C. Mix 10.0g lavender oil, 4.0g sandalwood oil, 2.0g agarwood extract, and 2.0g menthol evenly to prepare the oil phase. While maintaining the main bowl in shear mode, adjust the speed to 1200 rpm and add the above oil phase dropwise into the main bowl system (dropping time is 3 minutes). After the dropwise addition is complete, continue shearing for 3 minutes to ensure the essential oils are evenly dispersed.

[0114] (6) Dissolve 7.5g of pink passion fruit extract, 7.5g of jujube seed extract, 7.5g of polygala root extract, and 7.5g of prepared rehmannia root extract in 20.0g of glycerin to prepare a traditional Chinese medicine extract. Set the speed of the main pot to 200 rpm, add the above traditional Chinese medicine extract, then add the remaining 40.0g of glycerin and 20.0g of butylene glycol, and stir at low speed for 10 minutes until well mixed;

[0115] (7) Take a sample to test the pH value, adjust the pH value to 5.5, and let it stand at room temperature for 24 hours to defoam, thus obtaining the mask liquid with the function of improving sleep quality. This mask liquid can be used to impregnate non-woven fabric to make sheet masks.

[0116] Example 4

[0117] A soothing cream with sleep-improving properties

[0118] 1. Components:

[0119] γ-Aminobutyric acid 1.2%;

[0120] Isosorbide dimethyl ether 6.0% Butanediol 5.0%;

[0121] Ammonium polyacrylamide dimethyl taurate 1.0%;

[0122] Glycerin 5.0%;

[0123] Plant extract compound 2.5% (pink passionflower fruit extract: jujube seed extract: polygala extract: rehmannia root extract = 1:1:1:1);

[0124] 1.5% aromatic essential oil (lavender oil: sandalwood oil: agarwood extract = 4:1.5:0.8);

[0125] Menthol 0.3%;

[0126] p-Hydroxyacetophenone 0.4%;

[0127] 1,2-Hexanediol 0.4%;

[0128] Adjust the pH to 5.5 with appropriate amounts of citric acid / sodium citrate;

[0129] Deionized water balance.

[0130] 2. Preparation method

[0131] This embodiment prepared a soothing cream with a total mass of 1000g, focusing on verifying the boundary conditions of the process parameters. The specific steps are as follows:

[0132] (1) Weigh 12.0g of γ-aminobutyric acid, add it to a mixture of 60.0g of isosorbide dimethyl ether and 20.0g of butanediol, place it in a water bath and heat it to 40°C. Stir at 300 rpm for 15 minutes until the solution is completely clear and transparent to obtain the osmosis precursor solution.

[0133] (2) Add 785g of deionized water to a clean main emulsifying pot, turn on the stirring at 50 rpm, slowly sprinkle in 10.0g of polyacrylamide dimethyl taurate ammonium powder to prevent clumping, turn on the high-speed shear emulsifier, set the speed to 2000 rpm, shear for 5 minutes until a transparent gel base is formed.

[0134] (3) Reduce the speed of the main pot to 400 rpm, slowly pour the permeation precursor solution obtained in step (1) into the gel base in step (2), and continue stirring for 5 minutes until the system is completely homogeneous.

[0135] (4) Weigh 4.0g of p-hydroxyacetophenone and add it to 15.0g of butanediol. Heat to 78°C and stir until completely dissolved to obtain a clear premixed preservative solution. Maintain the temperature of the main pot at 78°C and slowly add the premixed preservative solution to the system in step (3) while stirring at 200 rpm. Mix evenly. Then add 4.0g of 1,2-hexanediol and continue stirring for 5 minutes.

[0136] (5) Stop heating and start the cooling cycle to lower the system temperature to below 35°C. Mix 7.5g lavender oil, 2.8g sandalwood oil, 1.5g agarwood extract and 3.0g menthol evenly to prepare the oil phase. Keep the main pot in shear mode, adjust the speed to 1000 rpm, and add the above oil phase to the main pot system (the adding time is 5 minutes). After the adding is complete, continue shearing for 2 minutes to make the essential oil disperse evenly.

[0137] (6) Dissolve 6.25g of pink passion fruit extract, 6.25g of jujube seed extract, 6.25g of polygala root extract, and 6.25g of prepared rehmannia root extract in 15.0g of glycerin to prepare a traditional Chinese medicine extract. Set the speed of the main pot to 100 rpm, add the above traditional Chinese medicine extract, then add the remaining 35.0g of glycerin and 15.0g of butylene glycol, and stir at low speed for 10 minutes until well mixed;

[0138] (7) Take a sample to test the pH value, adjust the pH value to 5.5, and let it stand at room temperature for 12 hours to defoam, and the soothing cream with the function of improving sleep quality is obtained.

[0139] Comparative Example 1

[0140] Based on Example 1, isosorbide dimethyl ether was not added, but an equal amount of deionized water was used instead, and the rest remained the same as in Example 1.

[0141] Comparative Example 2

[0142] Based on Example 1, step (1) of the premixing operation was cancelled, γ-aminobutyric acid was directly dissolved in water, and isosorbide dimethyl ether was directly added to the oil phase, while the rest remained the same as in Example 1.

[0143] Comparative Example 3

[0144] Based on Example 1, the ratio of lavender oil: sandalwood oil: agarwood extract was adjusted to 10:2:1, while the rest remained the same as in Example 1.

[0145] Comparative Example 4

[0146] Based on Example 1, the ratio of lavender oil: sandalwood oil: agarwood extract was adjusted to 5:5:1, while the rest remained the same as in Example 1.

[0147] Comparative Example 5

[0148] Based on Example 1, the ratio of lavender oil: sandalwood oil: agarwood extract was adjusted to 5:2:4, while the rest remained the same as in Example 1.

[0149] Comparative Example 6

[0150] Based on Example 1, without adding pink passion fruit extract, the ratio of jujube seed extract: polygala extract: rehmannia extract was changed to 1:1:1, and the rest remained the same as in Example 1.

[0151] Comparative Example 7

[0152] Based on Example 1, without adding pink passion fruit extract, the ratio of jujube seed extract: polygala extract: rehmannia extract was changed to 2:1:1, and the rest remained the same as in Example 1.

[0153] Comparative Example 8

[0154] Based on Example 1, without adding jujube seed extract, the ratio of pink passion fruit extract: polygala extract: rehmannia extract was changed to 1:2:1, and the rest remained the same as in Example 1.

[0155] Comparative Example 9

[0156] Based on Example 1, without adding Polygala tenuifolia extract, the ratio of pink passion fruit extract: jujube seed extract: Rehmannia glutinosa extract was changed to 1:2:1, and the rest remained the same as in Example 1.

[0157] Comparative Example 10

[0158] Based on Example 1, without adding Rehmannia glutinosa extract, the ratio of pink passion fruit extract: jujube seed extract: polygala extract was changed to 1:1:2, and the rest remained the same as in Example 1.

[0159] Comparative Example 11

[0160] Based on Example 1, ammonium polyacrylamide dimethyl taurate was replaced with an equal amount of carbomer 940, and the rest remained the same as in Example 1.

[0161] Performance testing:

[0162] Transdermal absorption: The transdermal absorption of γ-aminobutyric acid in Examples 1-2 and Comparative Examples 1-2 was tested using the Franz diffusion cell method according to T / CAFFCI 87-2025 standard.

[0163] Fresh pig back skin was harvested, subcutaneous fat was removed, and the thickness was controlled to 0.6 mm. The skin was fixed in a diffusion chamber with the cuticle facing the donor chamber. The receiving chamber was filled with PBS buffer (pH 7.4) containing 0.5% sodium azide and kept at a constant temperature of 32°C with magnetic stirring. 10 mg of each sample was evenly applied to the skin surface. Five hours after administration, 1.0 mL of sample was collected from the receiving chamber. After derivatization, the γ-aminobutyric acid (GABA) content was determined by HPLC, and the cumulative permeate was calculated.

[0164] Gradient release:

[0165] Ten perfumers were recruited and, after basic training, were trained to identify the basic scent characteristics of peppermint, agarwood, lavender, and sandalwood. 50mg of samples from the examples and comparative samples were evenly coated onto 5cm x 5cm cotton cloth sheets. The coated cloth sheets were placed on a 37°C constant-temperature heating plate, and tests were conducted at four time points: 5 minutes (immediately), 30 minutes (induction period), 2 hours (maintenance period), and 6 hours (long-lasting effect). The perfumers placed the cloth sheets under their noses for 2 seconds. At a distance of 3cm, gently fan the air and rate the intensity of the mint, agarwood, lavender, and sandalwood scents (0 points: odorless, 1 point: very faint, requires careful identification, 2 points: faint, identifiable, 3 points: moderate, clearly odorable, 4 points: strong, 5 points: extremely strong, pungent).

[0166] Sleep aid effect:

[0167] Sixty volunteers with mild insomnia (PSQI>7) were recruited and randomly divided into 12 groups. They used the product from Example 1 and the comparative example, respectively, applying it every night before bed for 28 consecutive days. Changes in total PSQI score and deep sleep duration were measured.

[0168] Table 1. Results of transdermal absorption and sleep-aiding effects tests for the examples and comparative samples.

[0169]

[0170] Table 2. Aroma gradient release test results for the examples and comparative samples.

[0171]

[0172] B is mint scent, T is sandalwood scent, X is lavender scent, and C is agarwood scent.

[0173] Test data show that Examples 1-4 of this invention, through the synergistic effect of the premixing process of γ-aminobutyric acid and isosorbide dimethyl ether and the specific essential oil ratio, achieved significant transdermal enhancement and sleep improvement effects, which are significantly better than Comparative Examples 1-2, which lack penetration enhancers or premixing processes. At the same time, sensory evaluation confirmed that Examples 1-4 successfully constructed a three-stage aroma gradient, while Comparative Examples 3-5 suffered from chaotic aroma layers due to the imbalance of essential oil ratios, and Comparative Example 11 suffered from extremely short fragrance retention (only 0.5 minutes of sandalwood after 6 hours) due to matrix defects. Ultimately, these comparative examples were significantly less effective than the Example group in shortening the time to fall asleep and increasing the duration of deep sleep. In addition, the data fluctuations of Comparative Examples 6-10 further verified the stability and necessity of the compounding of four Chinese herbal extracts.

[0174] The above description is merely a preferred embodiment of the present invention and is not intended to limit the present invention in any way. Although the present invention has been disclosed above with reference to preferred embodiments, it is not intended to limit the present invention. Any person skilled in the art can make some modifications or alterations to the above-disclosed technical content to create equivalent embodiments without departing from the scope of the present invention. Any simple modifications, equivalent changes and alterations made to the above embodiments based on the technical essence of the present invention without departing from the scope of the present invention shall still fall within the scope of the present invention.

Claims

1. A composition having the function of improving sleep quality, characterized in that, By weight percentage, it includes the following components: 5-10% Butanediol; 3-7% glycerin; 0.5-1.5% γ-aminobutyric acid; 0.5-3% plant extract compound, wherein the compound comprises pink passion fruit extract, jujube seed extract, polygala root extract and prepared rehmannia root extract in a weight ratio of 1:1:1:1; 0.5-2% aromatic essential oil, wherein the aromatic essential oil comprises lavender oil, sandalwood oil and agarwood extract in a weight ratio of (3-5):(1-2):(0.5-1); 0.05-0.5% Menthol; 0.1-1% thickener, selected from ammonium polyacrylamide dimethyl taurate; 1-5% skin conditioning agent containing isosorbide dimethyl ether; 0.1-1% p-hydroxyacetophenone; 0.1-1% 1,2-Hexanediol; The rest is deionized water; The weight ratio of isosorbide dimethyl ether to γ-aminobutyric acid is 2:1 to 10:

1. The method for preparing the composition having the function of improving sleep quality includes the following steps: (1) Add γ-aminobutyric acid to a mixture of isosorbide dimethyl ether and part of butanediol, heat to 40-50℃ and stir until completely clear to obtain a permeation precursor solution; (2) Add polyacrylamide dimethyl taurate ammonium to deionized water and shear until it is completely swollen to form a transparent gel substrate; (3) Add the permeation precursor solution obtained in step (1) to the gel substrate in step (2) and mix well; (4) Add p-hydroxyacetophenone to the remaining butanediol, heat to 75-85℃ and stir until completely dissolved, add to the system of step (3), mix evenly, and then add 1,2-hexanediol; (5) When the system temperature drops below 35°C, lavender oil, sandalwood oil, agarwood extract and menthol are premixed to form an oil phase, and then added dropwise to the system in step (4) under shear conditions to emulsify and disperse. (6) Pre-dissolve pink passion fruit extract, jujube seed extract, polygala extract and prepared rehmannia extract in glycerin, add to the system of step (5), and stir evenly; (7) Adjust the pH value to 5.0-6.0, let it stand to defoam, and you will get the product.

2. The composition with sleep quality improvement function according to claim 1, characterized in that, The composition is a gel, cream, serum, or mask formulation.

3. The composition with sleep quality improvement function according to claim 1, characterized in that, The jujube seed extract and polygala extract were obtained by supercritical CO2 extraction or ethanol reflux extraction.

4. The composition with sleep quality improvement function according to claim 1, characterized in that, The shearing speed in step (2) is 2000-3000 rpm, and the time is 5-10 minutes.

5. The composition with sleep quality improvement function according to claim 1, characterized in that, The shearing speed in step (5) is 1000-1500 rpm, and the time is 2-5 minutes.

6. The composition with sleep quality improvement function according to claim 1, characterized in that, The stirring speed in step (6) is 100-300 rpm.

7. The composition having the function of improving sleep quality according to claim 1, characterized in that, The settling and defoaming time in step (7) is 12-24 hours, so that the gel network can rearrange and securely encapsulate the low-volatility essential oil components.

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