Targeting Trop2 polypeptide and molecular probe and application thereof

By using artificial intelligence to design targeted Trop2 peptides and conjugate them with radionuclides to construct peptide probes, the systemic toxicity and invasiveness of detection in existing Trop2 targeted therapies have been solved. This enables non-invasive, high-sensitivity imaging and integrated diagnosis and treatment, and is suitable for the early diagnosis and personalized treatment of various Trop2-overexpressing tumors.

CN122060022APending Publication Date: 2026-05-19XUANWU HOSPITAL OF CAPITAL UNIV OF MEDICAL SCI
0 Cites 1 Cited by

Patent Information

Application Number
CN202610082927.7
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-01-21
Publication Date
2026-05-19

AI Technical Summary

Technical Problem

Existing Trop2-targeted therapy strategies suffer from systemic toxicity, drug tolerance, and heterogeneity in efficacy. Traditional detection methods are highly invasive and difficult to monitor dynamically. There is a lack of non-invasive and dynamic methods for assessing Trop2 expression. Existing peptide probes have large molecular weights, limited tumor penetration, long imaging cycles, and high costs.

Method used

We designed and synthesized peptides targeting Trop2, and obtained peptides with high selectivity and affinity through artificial intelligence-aided design and high-throughput screening technology. We then constructed molecular probes coupled with radionuclides to achieve non-invasive and highly sensitive imaging of Trop2-positive tumors, and these probes can be coupled with therapeutic agents for integrated diagnosis and treatment.

Benefits of technology

This technology enables a combination of non-invasive, rapid imaging and treatment of Trop2-positive tumors, reducing background signal, shortening the imaging cycle, improving targeting and stability, and reducing preparation costs, making it suitable for clinical applications.

✦ Generated by Eureka AI based on patent content.
Patent Text Reader

Abstract

The invention relates to the technical field of tumor molecular imaging, nuclear medicine diagnosis and targeted therapy, and discloses a Trop2-targeted polypeptide, a Trop2-targeted molecular probe and application of the Trop2-targeted polypeptide and the Trop2-targeted molecular probe. The polypeptide can be coupled with different imaging elements to construct molecular probes or radiopharmaceuticals for tumor targeted imaging, so that noninvasive visual detection on the Trop2 expression level in tumor tissues is realized. The probe can specifically recognize Trop2 positive solid tumors, and a new technical means is provided for noninvasive diagnosis and dynamic monitoring of various Trop2 high-expression tumors such as pancreatic cancer, lung cancer, breast cancer and thyroid cancer. The probe disclosed by the invention has the advantages of simple preparation process, low cost, high specificity and stability, short imaging period, low radiation dosage, easiness in clinical transformation and the like, and has a wide application prospect in precise diagnosis and individualized treatment of tumors.
Need to check novelty before this filing date? Find Prior Art