A fungicidal composition containing chlorfluazuron, a fungicidal formulation containing the same composition, and its uses.

Abstract

This invention discloses a fungicide composition containing chlorfluazuron, a fungicide formulation containing the fungicide composition, and its uses. The fungicide composition includes chlorfluazuron and a compound fungicide component, wherein the compound fungicide component is selected from any one of fluopyram, cyazofamid, and prochloraz. The uses refer to the application of the fungicide composition in the preparation of agents for the control of crop diseases. The fungicide composition of this invention consists of active ingredients with different mechanisms of action, and when mixed, it exhibits a significant synergistic effect, improving the control efficacy. It also helps to overcome and delay the development of drug resistance in diseases, and can be used to develop novel and highly effective agents for the control of wheat scab and corn ear rot.

Description

Technical Field

[0001] This invention relates to the field of pesticide technology, and in particular to a fungicide composition containing chlorfluazuron, a fungicide formulation containing the fungicide composition, and its uses. Background Technology

[0002] Chlorfluazuron is a novel isopropanol triazole fungicide. Its mechanism of action involves inhibiting the C-14 demethylase in the ergosterol biosynthesis pathway of pathogenic fungi, preventing ergosterol synthesis and leading to abnormal fungal cell membrane function, ultimately causing cell death and achieving both antibacterial and fungicidal effects. It possesses advantages such as high efficiency, broad spectrum, low toxicity, and delayed resistance development. It can be used to control diseases caused by many pathogens, including Fusarium, Rice blast fungus, *Microcystis aeruginosa*, *Dioscorea opposita*, *Alternaria alternata*, and *Powdery mildew*, such as wheat scab, corn ear rot, citrus anthracnose, rice blast, apple brown spot, banana leaf spot, potato early blight, and cucumber powdery mildew. Furthermore, chlorfluazuron has excellent systemic conductivity, allowing it to be absorbed by the roots, stems, and leaves of plants and transported within the plant, providing protective, curative, and eradicative effects against diseases, with a long-lasting effect.

[0003] Chemical fungicides are effective in controlling plant diseases, but long-term use of a single chemical pesticide can easily lead to a series of problems such as pathogens developing resistance, reduced efficacy, increased dosage, soil pollution, and disruption of the ecological balance. Summary of the Invention

[0004] The main objective of this invention is to provide a bactericidal composition containing chlorfluazuron, a bactericidal preparation containing the bactericidal composition, and its use, in order to solve at least one of the aforementioned technical problems.

[0005] To achieve the above objectives, the present invention provides a bactericidal composition containing chlorfluazuron, comprising chlorfluazuron and a combined bactericidal component, wherein the combined bactericidal component is selected from any one of fluopyram, cyazofamid, and prochloraz.

[0006] Furthermore, the fungicidal composition is used to control wheat scab. The fungicidal composition includes chlorfluazuron and fluopyram, with a mass ratio of 20:1 to 1:20, preferably 3 to 5:1 or 1:3 to 5; or the fungicidal composition includes chlorfluazuron and cyazofamid, with a mass ratio of 20:1 to 1:20, preferably 10 to 20:1, 1:3 or 1:10; or the fungicidal composition includes chlorfluazuron and prochloraz, with a mass ratio of 20:1 to 1:20, preferably 3:1 or 1:3 to 20.

[0007] Furthermore, the fungicidal composition is used to control corn ear rot, and the fungicidal composition includes chlorfluazuron and fluopyram in a mass ratio of 20:1 to 1:20, preferably 1 to 20:1; or the fungicidal composition includes chlorfluazuron and prochloraz in a mass ratio of 20:1 to 1:20, preferably 3 to 20:1.

[0008] The present invention also provides a fungicide comprising the above-mentioned fungicide composition containing chlorfluazuron and agriculturally acceptable adjuvants, wherein the fungicide is in an agriculturally acceptable formulation.

[0009] Furthermore, the bactericidal preparation is in the form of a suspension or water-dispersible granules.

[0010] Furthermore, the auxiliary component is any one or a mixture of two or more of the following: solvent, emulsifier, stabilizer, dispersant, thickener, defoamer, surfactant, and filler. The auxiliary component is a known substance, a variety of adjuvants commonly used in pesticide formulations, and may vary depending on the specific circumstances; there are no particular limitations.

[0011] The present invention also provides the use of the above-mentioned bactericidal composition in the preparation of agents for the prevention and control of crop diseases.

[0012] Furthermore, the agent is an agent for controlling wheat scab and / or corn ear rot.

[0013] Fluopyram is a pyridine amide fungicide that acts on succinate dehydrogenase. Its mechanism of action involves interfering with the function of respiratory chain complex II, blocking the tricarboxylic acid cycle, and thus inhibiting the energy metabolism of pathogen mitochondria, achieving a fungicidal effect. Fluopyram has the advantages of high efficiency and broad spectrum, but also has disadvantages such as easy development of resistance and potential risks to aquatic organisms. It can be used to control wheat scab, corn ear rot, rapeseed sclerotinia stem rot, rice bakanae disease, soybean leaf spot, and peanut leaf spot, among others.

[0014] Cyazofamid belongs to the cyanoacrylate class of fungicides. Its mechanism of action is to exert its fungicidal effect by inhibiting the activity of myosin ATPase in pathogenic bacteria. It has the advantages of high efficiency, low toxicity, low residue and environmental friendliness. It has protective and curative effects on various plant diseases caused by Fusarium spp. and can be used to control wheat scab, rice bakanae disease, cotton wilt, strawberry wilt, banana Panama disease and watermelon wilt caused by Fusarium.

[0015] Imazalil belongs to the imidazole class of fungicides and has the characteristics of broad spectrum, high efficiency, systemic absorption and low toxicity. It has obvious control effect on diseases caused by ascomycetes and deuteromycetes in a variety of crops. It can also be mixed with most fungicides, insecticides and herbicides, and all have good control effects. It has therapeutic and eradicative effects on a variety of diseases on field crops, fruits and vegetables, turf and ornamental plants.

[0016] This invention combines chlorfluazuron with fluopyram, cyazofamid, or prochloraz, and under certain mass ratios, they can synergistically enhance the effects, reduce costs, achieve the goal of treating multiple diseases, and effectively delay the development of drug resistance in pathogens.

[0017] The beneficial effects of this invention are reflected in: The bactericidal composition of this invention consists of effective ingredients with different mechanisms of action. When mixed, they have a significant synergistic effect, which improves the control effect. At the same time, it helps to overcome and delay the development of drug resistance in diseases. It can be used to develop new and highly efficient agents for the control of wheat scab and corn ear rot.

[0018] The bactericidal composition of the present invention reduces the amount of pesticide used, lowers costs, reduces environmental pollution, has good safety, and meets the safety requirements of pesticide formulations. Detailed Implementation

[0019] To enable those skilled in the art to more clearly understand the technical solutions described in this invention, the following embodiments are provided for illustration. It should be noted that the following embodiments do not constitute a limitation on the scope of protection claimed by this invention.

[0020] Unless otherwise specified, the raw materials, reagents or devices used in the following embodiments can be obtained from conventional commercial sources or by existing known methods; unless otherwise specified, the methods used in the embodiments of the present invention are methods mastered by those skilled in the art.

[0021] Example 1 Indoor toxicity test of a single fungicide component against wheat scab. The test pathogen was Fusarium graminearum, which was collected from the field, isolated, and preserved for later use.

[0022] Test reagents: chlorfluazuron technical (purity 97%), fluopyram technical (purity 98%), cyazofamid technical (purity 95%), and prochloraz technical (purity 96%), all commercially available.

[0023] Experimental Methods: The mycelial growth rate method was used to determine the inhibitory effects of four single fungicides—chlorfluazuron, fluopyram, cyazofamid, and prochloraz—on the mycelial growth of *Fusarium graminearum*. Based on preliminary experiments, the concentrations of chlorfluazuron were set at 0.1, 0.2, 0.4, 0.8, 1.6, 3.2, and 6.4 mg / L; the concentrations of fluopyram were set at 0.01, 0.02, 0.04, 0.08, 0.16, 0.32, 0.64, and 1.28 mg / L; the concentrations of cyazofamid were set at 0.05, 0.1, 0.2, 0.4, 0.8, 1.6, and 3.2 mg / L; and the concentrations of prochloraz were set at 0.01, 0.02, 0.04, 0.08, 0.16, 0.32, 0.64, and 1.28 mg / L. A blank control group was also included. The strain was activated using PDA medium, and mycelial blocks with a diameter of 5 mm were prepared using a punch and inoculated into the center of the drug-containing medium. The mixture was then incubated at 25°C. When the colony diameter of the blank control reached about 90% of the diameter of the culture dish, the colony diameter was measured using the cross-crossing method, and the mycelial growth inhibition rate was calculated according to formula (1).

[0024] (1) The mycelial growth inhibition rate was converted into an inhibition probability value (y), and the agent concentration was converted into a concentration logarithm (x). A virulence regression line was plotted with the concentration logarithm on the x-axis and the probability value on the y-axis to obtain the virulence regression equations for different agents against Fusarium graminearum, and the EC50 was calculated. 50 And the correlation coefficient r value.

[0025] Experimental results: As shown in Table 1, all four agents exhibited high inhibitory activity against Fusarium graminearum mycelial growth, EC 100%. 50 The concentrations ranged from 0.0754 to 0.4186 mg / L; among them, fluopyram had the highest activity, EC50. 50 The concentration was only 0.0754 mg / L; followed by cyazofamid, prochloraz, and chlorfluazuron, EC 100%. 50 The concentrations were 0.2668, 0.3099, and 0.4186 mg / L, respectively.

[0026] Table 1. Results of toxicity tests of four fungicides against Fusarium graminearum.

[0027] Example 2 Indoor toxicity test of chlorfluazuron and fluopyram combined with wheat scab. The test pathogen was Fusarium graminearum, which was collected from the field, isolated, and preserved for later use.

[0028] Test reagents: chlorfluazuron technical grade (purity 97%) and fluopyram technical grade (purity 98%), commercially available.

[0029] Experimental method: The mycelial growth inhibition rate method was used (for specific preparation method, please refer to Example 1). The interaction between the mixture of chlorfluazuron and fluopyram was evaluated according to the Wadley method, and EC was calculated according to formulas (2) and (3). 50 (Theoretical value) and synergy factor (SR). (2) (3) In the formula: a and b are the proportions of each component in the mixture, EC 50 (A) EC 50 (B) Represents the EC values ​​of chlorfluazuron and fluopyram, respectively, for single agents. 50 The effect of the mixture is analyzed based on the SR value. If SR ≤ 0.5, the two drugs have an antagonistic effect; if SR = 0.5~1.5, the two drugs have an additive effect; if SR ≥ 1.5, the two drugs have a synergistic effect.

[0030] Experimental results: As shown in Table 2, both chlorfluazuron and fluopyram, as single agents, exhibited strong inhibitory effects on the mycelial growth of Fusarium graminearum. Chlorfluazuron's EC50... 50 The EC50 of fluopyram was 0.4186 mg / L. 50 The concentration was 0.0754 mg / L. When chlorfluazuron and fluopyram were mixed at certain mass ratios of 5:1, 3:1, 1:3, and 1:5, they exhibited a synergistic effect against Fusarium graminearum. Especially at ratios of 5:1 and 1:5, the EC50 concentration was significantly higher. 50 The values ​​were 0.0579 mg / L and 0.0175 mg / L, respectively, and the SR values ​​were 4.1105 and 5.6457, respectively, which showed a significant synergistic effect. It can effectively reduce the dosage of active ingredients and slow down the development of drug resistance.

[0031] Table 2. Virulence assay results of chlorfluazuron and fluopyram combined with Fusarium graminearum.

[0032] Example 3 Indoor toxicity test of chlorfluazuron and cyazofamid combination against wheat scab. The test pathogen was Fusarium graminearum, which was collected from the field, isolated, and preserved for later use.

[0033] Test reagents: Chlorfluazuron technical grade (97% purity) and Cyazofamid technical grade (95% purity), commercially available.

[0034] Experimental methods: The mycelial growth inhibition rate method was used (see Example 1 for specific preparation method). The synergistic effect of the mixture of chlorfluazuron and cyazofamid was evaluated according to the Wadley method (see Example 2).

[0035] Experimental results: As shown in Table 3, both chlorfluazuron and cyazofamid showed strong inhibitory effects on the mycelial growth of Fusarium graminearum. Chlorfluazuron's EC50 value was [not specified]. 50 The EC50 of cyazofamid was 0.4186 mg / L. 50 The concentration was 0.2668 mg / L. When chlorfluazuron and cyazofamid were mixed at a certain mass ratio, the SR value of the 10:1 mixture was 5.3784, higher than other combinations, indicating the most significant synergistic effect. EC 50 The concentration was 0.0740 mg / L; the SR values ​​of the mixed combinations 20:1, 15:1, 1:3 and 1:10 were 1.8921, 2.1838, 2.2797 and 2.2024, respectively, which also showed a synergistic effect.

[0036] Table 3. Virulence test results of chlorfluazuron and cyazofamid combination against Fusarium graminearum.

[0037] Example 4 Indoor toxicity test of chlorfluazuron and prochloraz combined for wheat scab. The test pathogen was Fusarium graminearum, which was collected from the field, isolated, and preserved for later use.

[0038] Test reagents: chlorfluazuron technical (purity 97%) and prochloraz technical (purity 96%), commercially available.

[0039] Experimental methods: The mycelial growth inhibition rate method was used (see Example 1 for specific preparation method). The synergistic effect of the mixture of chlorfluazuron and prochloraz was evaluated according to the Wadley method (see Example 2).

[0040] Experimental results: As shown in Table 4, both chlorfluazuron and prochloraz, as single agents, exhibited strong inhibitory effects on the mycelial growth of Fusarium graminearum. Chlorfluazuron's EC50 value was [not specified]. 50 The EC50 of imazalil was 0.4186 mg / L. 50 The concentration was 0.3099 mg / L. After mixing chlorfenapyr and prochloraz at certain mass ratios, EC was prepared in combinations of 3:1, 1:3, 1:5, 1:10, 1:15, and 1:20. 50The concentrations were 0.2490, 0.1516, 0.1533, 0.1462, 0.1421 and 0.1255 mg / L, with SR values ​​of 1.5456, 2.1861, 2.1129, 2.1709, 2.2168 and 2.5002, respectively, all of which showed significant synergistic effects.

[0041] Table 4. Virulence test results of chlorfluazuron and prochloraz combined with Fusarium graminearum

[0042] Example 5 Indoor toxicity test of a single fungicide component against corn ear rot The test pathogen was Fusarium verticillatum, which was collected from the field, isolated, and preserved for later use.

[0043] Test reagents: chlorfluazuron technical (purity 97%), fluopyram technical (purity 98%), cyazofamid technical (purity 95%), and prochloraz technical (purity 96%), all commercially available.

[0044] Experimental Methods: The mycelial growth rate method was used to determine the inhibitory effects of four single fungicides—chlorfluazuron, fluopyram, cyazofamid, and prochloraz—on the mycelial growth of *Fusarium verticillatum*. Based on preliminary experiments, the concentrations of chlorfluazuron were set at 0.01, 0.02, 0.04, 0.08, 0.16, 0.32, and 0.64 mg / L; the concentrations of fluopyram were set at 0.04, 0.08, 0.16, 0.32, 0.64, and 1.28 mg / L; the concentrations of cyazofamid were set at 0.1, 0.2, 0.4, 0.8, 1.6, 3.2, and 6.4 mg / L; and the concentrations of prochloraz were set at 0.0025, 0.005, 0.01, 0.02, 0.05, 0.10, 0.20, 0.40, and 0.80 mg / L (specific preparation methods are described in Example 1).

[0045] Experimental results: As shown in Table 5, prochloraz showed the highest inhibitory activity against the mycelial growth of Fusarium verticillatum, with an EC50 value of [missing value]. 50 Only 0.0149 mg / L, followed by fluopyram and chlorfenapyr, EC 50 The concentrations were 0.1490 and 0.1852 mg / L, respectively; while cyazofamid showed lower antibacterial activity, EC50. 50 It was 2.6620 mg / L.

[0046] Table 5. Results of toxicity tests of four fungicides against Fusarium verticillatum.

[0047] Example 6 Indoor toxicity test of chlorfluazuron and fluopyram combined with maize ear rot The test pathogen was Fusarium verticillatum, which was collected from the field, isolated, and preserved for later use.

[0048] Test reagents: chlorfluazuron technical grade (purity 97%) and fluopyram technical grade (purity 98%), commercially available.

[0049] Experimental methods: The mycelial growth inhibition rate method was used (see Example 1 for specific preparation method). The synergistic effect of the mixture of chlorfluazuron and fluopyram was evaluated according to the Wadley method (see Example 2).

[0050] Experimental results: As shown in Table 6, both chlorfluazuron and fluopyram, as single agents, exhibited strong inhibitory effects on the mycelial growth of *Fusarium verticillatum*. Chlorfluazuron's EC50... 50 The EC50 of fluopyram was 0.1490 mg / L. 50 The concentration was 0.1852 mg / L. When chlorfluazuron and fluopyram were mixed at a certain mass ratio (20:1 to 1:20), they showed synergistic and additive effects against *Fusarium verticillatum*, without antagonistic effects. Particularly at a ratio of 5:1, EC50 was significantly higher. 50 The value is 0.0882 mg / L, which shows excellent synergistic effect, and its SR value is greater than 1.5.

[0051] Table 6. Virulence assay results of the combination of chlorfluazuron and fluopyram to Fusarium verticillatum.

[0052] Example 7 Indoor toxicity test of chlorfluazuron and prochloraz combined for corn ear rot The test pathogen was Fusarium verticillatum, which was collected from the field, isolated, and preserved for later use.

[0053] Test reagents: chlorfluazuron technical (purity 97%) and prochloraz technical (purity 96%), commercially available.

[0054] Experimental methods: The mycelial growth inhibition rate method was used (see Example 1 for specific preparation method). The synergistic effect of the mixture of chlorfluazuron and prochloraz was evaluated according to the Wadley method (see Example 2).

[0055] Experimental results: As shown in Table 7, both chlorfluazuron and prochloraz, as single agents, exhibited strong inhibitory effects on the mycelial growth of *Fusarium verticillatum*. Chlorfluazuron's EC50... 50 The EC50 of imazalil was 0.1490 mg / L. 50The concentration was 0.0149 mg / L. When chlorfenapyr and prochloraz were mixed at a certain mass ratio (20:1 to 1:20), they showed synergistic and additive effects against *Fusarium verticillatum*, without antagonistic effects. Particularly at a ratio of 3:1, EC50 was significantly higher. 50 The value was 0.0197 mg / L, and the SR value was 2.3272, indicating a significant synergistic effect.

[0056] Table 7. Virulence assay results of chlorfluazuron and prochloraz combined with Fusarium oxysporum.

[0057] Example 8 Preparation of bactericidal agents I. 30% Chlorfluazuron·Fluoxam suspension concentrate It contains the following ingredients by weight percentage: 25% chlorfluazuron, 5% fluopyram, 6% castor oil polyoxyethylene ether, 4% sodium lignosulfonate, 0.01% xanthan gum, 2% silica, 0.02% tributyl phosphate, and 100% deionized water.

[0058] II. 30% Chlorfluazuron·Fluoxam Hydroxylamine Water Dispersible Granules It contains the following ingredients by weight percentage: 25% chlorfluazuron, 5% fluopyram, 2% sodium dodecylbenzenesulfonate, 4% ammonium sulfate, 4% sulfonate formaldehyde condensate, 0.2% polyvinyl alcohol, and 100% kaolin.

[0059] III. 36% Chlorfluazuron·Fluoxam suspension It contains the following ingredients by weight percentage: 27% chlorfluazuron, 9% fluopyram, 6% castor oil polyoxyethylene ether, 4% sodium lignosulfonate, 0.01% xanthan gum, 2% silica, 0.02% tributyl phosphate, and deionized water to make up to 100%.

[0060] IV. 21% Chlorfluazuron·Fluoxam suspension It contains the following ingredients by weight percentage: 20% chlorfluazuron, 1% fluopyram, 3% castor oil polyoxyethylene ether, 3% sodium lignosulfonate, 0.02% xanthan gum, 3% silica, 0.02% tributyl phosphate, and deionized water to make up to 100%.

[0061] V. 21% Chlorfluazuron·Fluoxam suspension concentrate It contains the following ingredients by weight percentage: 1% chlorfluazuron, 20% fluopyram, 4.5% castor oil polyoxyethylene ether, 3% sodium lignosulfonate, 0.02% xanthan gum, 3% silica, 0.02% tributyl phosphate, and deionized water to make up to 100%.

[0062] VI. 20% Chlorfluazuron·Prochloraz Oil Suspension It contains the following ingredients by weight percentage: 15% chlorfluazuron, 5% imazalil, 1.5% magnesium aluminum silicate, 3.5% fatty alcohol polyoxyethylene ether, 3% polyethylene glycol 600 dioleate, 3.5% calcium dodecylbenzenesulfonate, and methyl oleate to make up 100%.

[0063] VII. 21% Chlorfluazuron·Prochloraz Oil Suspension It contains the following ingredients by weight percentage: 1% chlorfluazuron, 20% imazalil, 2.5% magnesium aluminum silicate, 3.5% fatty alcohol polyoxyethylene ether, 2% polyethylene glycol 600 dioleate, 4.5% calcium dodecylbenzenesulfonate, and methyl oleate to make up 100%.

[0064] 8. 24% Chlorfluazuron·Prochloraz Oil Suspension It contains the following ingredients by weight percentage: 6% chlorfluazuron, 18% imazalil, 2% magnesium aluminum silicate, 3.5% fatty alcohol polyoxyethylene ether, 2% polyethylene glycol 600 dioleate, 4.5% calcium dodecylbenzenesulfonate, and methyl oleate to make up 100%.

[0065] 9. 24% Chlorfluazuron·Prochloraz Oil Suspension It contains the following ingredients by weight percentage: chlorfluazuron 4%, prochloraz 20%, magnesium aluminum silicate 2%, fatty alcohol polyoxyethylene ether 3.5%, polyethylene glycol 600 dioleate 2%, calcium dodecylbenzene sulfonate 4.5%, and methyl oleate to make up 100%.

[0066] 10. 24% Chlorfluazuron·Prochloraz Oil Suspension It contains the following ingredients by weight percentage: 20% chlorfluazuron, 4% imazalil, 2% magnesium aluminum silicate, 3.5% fatty alcohol polyoxyethylene ether, 3% polyethylene glycol 600 dioleate, 3.5% calcium dodecylbenzenesulfonate, and methyl oleate to make up 100%.

[0067] XI. 44% Chlorfluazuron·Prochloraz Water Dispersible Granules It contains the following ingredients by weight percentage: 40% chlorfluazuron, 4% imazalil, 2% sodium diisobutylnaphthalene sulfonate, 4% ammonium sulfate, 4% sodium lignosulfonate, 0.2% polyvinyl alcohol, and organic bentonite to make up 100%.

[0068] 12. 42% Chlorfluazuron·Prochloraz Water Dispersible Granules It contains the following ingredients by weight percentage: 40% chlorfluazuron, 2% imazalil, 2% sodium diisobutylnaphthalene sulfonate, 4% ammonium sulfate, 4% sodium lignosulfonate, 0.2% polyvinyl alcohol, and organic bentonite to make up 100%.

[0069] 13. 44% Chlorfluazuron·Cyclopyralid Suspension Concentrate It contains the following ingredients by weight percentage: 4% chlorfluazuron, 40% cyazofamid, 4.7% fatty alcohol polyoxyethylene ether, 2.3% sodium lignosulfonate, 0.02% xanthan gum, 2% silica, 0.02% tributyl phosphate, and deionized water to make up to 100%.

[0070] XIV. 20% Chlorfluazuron·Cyclopyralid Suspension Concentrate It contains the following ingredients by weight percentage: 5% chlorfluazuron, 15% cyazofamid, 4.3% fatty alcohol polyoxyethylene ether, 2.2% sodium lignosulfonate, 0.02% xanthan gum, 2% silica, 0.02% tributyl phosphate, and deionized water to make up to 100%.

[0071] 15. 44% Chlorfluazuron·Cypermethrin Water Dispersible Granules It contains the following ingredients by weight percentage: 40% chlorfluazuron, 4% cyazofamid, 2% sodium dodecylbenzenesulfonate, 4% calcium lignosulfonate, 4% sodium chloride, 0.2% polyvinyl alcohol, and 100% kaolin.

[0072] XVI. 64% Chlorfluazuron·Cyclopyralid Water Dispersible Granules It contains the following ingredients by weight percentage: 60% chlorfluazuron, 4% cyazofamid, 2.5% sodium dodecylbenzenesulfonate, 5% calcium lignosulfonate, 5% sodium chloride, 0.2% polyvinyl alcohol, and 100% kaolin.

[0073] 17. 42% Chlorfluazuron·Cyclopyralid Water Dispersible Granules It contains the following ingredients by weight percentage: 40% chlorfluazuron, 2% cyazofamid, 2% sodium dodecylbenzenesulfonate, 4% calcium lignosulfonate, 4% sodium chloride, 0.2% polyvinyl alcohol, and 100% kaolin.

[0074] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A bactericidal composition containing chlorfluazuron, characterized in that, It includes chlorfluazuron and a combined fungicide component, wherein the combined fungicide component is selected from any one of fluopyram, cyazofamid, and prochloraz.

2. The bactericidal composition containing chlorfluazuron as described in claim 1, characterized in that, The fungicidal composition is used to control wheat scab. The fungicidal composition includes chlorfluazuron and fluopyram in a mass ratio of 20:1 to 1:20; or the fungicidal composition includes chlorfluazuron and cyazofamid in a mass ratio of 20:1 to 1:20; or the fungicidal composition includes chlorfluazuron and prochloraz in a mass ratio of 20:1 to 1:

20.

3. The bactericidal composition containing chlorfluazuron as described in claim 1, characterized in that, The fungicide composition is used to control corn ear rot. The fungicide composition includes chlorfluazuron and fluopyram in a mass ratio of 20:1 to 1:20; or the fungicide composition includes chlorfluazuron and prochloraz in a mass ratio of 20:1 to 1:

20.

4. A bactericidal agent, characterized in that, The fungicide composition comprising chlorfluazuron as described in claim 1, 2 or 3, and agriculturally acceptable adjuvants, wherein the fungicide is formulated in an agriculturally acceptable formulation.

5. The bactericidal agent as described in claim 4, characterized in that, The bactericidal formulation is in the form of a suspension or water-dispersible granules.

6. The bactericidal agent according to claim 4, characterized in that, The auxiliary components are any one or a mixture of two or more of the following: solvent, emulsifier, stabilizer, dispersant, thickener, defoamer, surfactant, and filler.

7. Use of the bactericidal composition as described in claim 1, 2 or 3 in the preparation of agents for the prevention and control of crop diseases.

8. The use as described in claim 7, characterized in that, The agent is used to control wheat scab and / or corn ear rot.

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