A penetrating water-based insecticidal aerosol and a method for preparing the same

Abstract

The application discloses a kind of permeability water-based insecticidal aerosol and its preparation method.The weight percentage composition of the insecticidal aerosol includes: pyrethroid 0.5~1.0%, dimethyl sulfoxide 1~2%, emulsifier 0.5~1.0%, penetrating agent 0.4~0.8%, antifreeze 2~3%, essence 0~0.5%, propellant 40~50%, and the rest is deionized water;Wherein the penetrating agent is lipase and orange peel essential oil composition.By dimethyl sulfoxide solubilization makes pyrethroid dissolve and further emulsification to form oil-in-water nano liquid, not only storage stable, but also promote the infiltration and spread of aerosol in the waxy shell of pests;Formulation uses the penetrating agent of lipase and orange peel essential oil composition, can quickly dissolve the waxy of pest surface, break through lipid barrier, realize the adhesion and rapid penetration of pesticide, so as to play the effect of synergistic insecticidal.Not only reduce the pollution to home environment, but also realize the reduction of application and efficiency.

Description

Technical Field

[0001] This invention relates to environmentally friendly insecticidal aerosols, particularly water-based insecticidal aerosols that enhance killing effect by increasing permeability, specifically a permeable water-based insecticidal aerosol and its preparation method. Background Technology

[0002] Most current insecticidal aerosols use pyrethroids (such as permethrin, cypermethrin, and deltamethrin) as their active ingredient, dissolved in oil-based solvents (esters, ketones, petroleum fractions) and packaged with a propellant. Oil-based insecticidal aerosols have a significant adhesion and penetration effect on the surface of pests such as cockroaches, ants, mosquitoes, and flies, quickly penetrating their exoskeletons to achieve excellent killing effects. They are commonly used for pest control in homes and public places. However, oil-based insecticidal aerosols have high VOC (volatile organic compound) content, are flammable and explosive, and highly irritating. Using them in the home not only increases VOC levels but also easily penetrates and remains on curtains, sofas, and bedding, polluting and damaging home textiles.

[0003] With increasing public awareness of safety, health, and environmental protection, water-based insecticidal aerosols have become a popular and widely promoted green insecticidal aerosol product. Water-based insecticidal aerosols use water as a solvent and surfactants to evenly disperse the active ingredients, significantly reducing VOC emissions and offering high environmental friendliness and safety. However, the effectiveness of water-based insecticidal aerosols in killing pests has historically been less than ideal. This is mainly because pests have a waxy, hydrophobic body surface, preventing water-based aerosols from quickly penetrating and adhering to the insect's surface, thus hindering the effective adhesion of the active ingredients and resulting in limited efficacy. To improve the killing effect of water-based insecticidal aerosols, some alkane solvents are typically used to break down the waxy layer of the insect's exoskeleton. However, this method easily pollutes the home environment, produces a strong odor, and can pose a health hazard to humans and the living environment. Summary of the Invention

[0004] In order to improve the environmental friendliness of insecticidal aerosols and achieve high-efficiency killing effect with reduced application, this invention provides a penetrating water-based insecticidal aerosol and its preparation method.

[0005] A penetrating water-based insecticidal aerosol, comprising, by weight percentage: 0.5-1.0% pyrethroids, 1-2% dimethyl sulfoxide, 0.5-1.0% emulsifier, 0.4-0.8% penetrant, 2-3% antifreeze, 0-0.5% fragrance, 40-50% propellant, and the balance being deionized water; wherein: The pyrethroid is a mixture of two or more of ES bio-allethrin, methamidophos, permethrin, cis-cypermethrin, cyhalothrin, and dextromethorphan in any proportion. The emulsifier is a nonionic surfactant with a hydrophilic-lipophilic balance value in the range of 10-18; The penetrant is composed of lipase and orange peel essential oil in a mass ratio of 1:(1~2).

[0006] Pyrethroids mimic the chemical structure of natural pyrethrin, exhibiting high efficiency, broad spectrum, biodegradability, and low toxicity to mammals. By combining different pyrethroids with knockdown and lethal effects, more effective knockdown and lethality can be achieved against a variety of pests. Preferably, the pyrethroid is a mixture of ES bio-allethrin, permethrin, and cis-cypermethrin in a mass ratio of 4:2:1; more preferably, the pyrethroid is a mixture of cis-cypermethrin, permethrin, and permethrin in a mass ratio of 2:2:1; even more preferably, the pyrethroid is a mixture of permethrin, cis-cypermethrin, and cyhalothrin in a mass ratio of 2:1:1.

[0007] Because pyrethroids disperse poorly in water, emulsions produced during emulsification often have large particle sizes (typically in the micrometer range), resulting in unstable dispersion, easy stratification and flocculation, which is detrimental to the dispersion and absorption of the active ingredients. Using dimethyl sulfoxide (DMSO) as a solubilizer allows for the complete dissolution of pyrethroids before emulsification, yielding a nanoscale emulsion. This not only ensures stable dispersion but also facilitates the spread and penetration of the nanoscale emulsion onto the insect's exoskeleton. Furthermore, DMSO's lipid-soluble properties promote the penetration of the nanoscale emulsion into the insect's body surface.

[0008] Preferably, the emulsifier is at least one of polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan monostearate, and polyoxyethylene sorbitan monopalmitate. Emulsifying pyrethroids with a nonionic surfactant having a hydrophilic-lipophilic balance (HLB) value in the range of 10-18 gives the water-based insecticidal aerosol a low surface tension, allowing it to spread and adhere easily to the surface of pests.

[0009] Preferably, the lipase has an enzyme activity ≥30000 u / g. The lipase has a CAS number of 9001-62-1, and commercially available lipases in powder or liquid form can be selected. Lipase is readily soluble in water and has a rapid decomposition effect on lipids. It has mature applications in powerful degreasing cleaners and can quickly decompose stubborn grease stains; orange peel essential oil can effectively dissolve wax. Pyrethroids kill pests such as cockroaches, mosquitoes, and flies mainly by penetrating their waxy body surfaces. The combination of lipase and orange peel essential oil, as a penetrant, can assist aerosols in quickly dissolving the waxy surface of pests, breaking through the lipid barrier, and achieving adhesion and rapid penetration of the pesticide, thereby enhancing the insecticidal effect. At the same time, the penetrant composed of lipase and orange peel essential oil will not damage or pollute the home environment.

[0010] Preferably, the antifreeze is at least one of ethylene glycol, propylene glycol, and glycerol. Adding the antifreeze prevents the water-based insecticide aerosol from freezing and demulsifying when stored in low-temperature environments.

[0011] Preferably, the fragrance is selected from either jasmine fragrance or peppermint fragrance.

[0012] Preferably, the propellant is either compressed nitrogen or liquefied petroleum gas.

[0013] In another aspect, the present invention provides a method for preparing a penetrating water-based insecticidal aerosol, the specific preparation method being as follows: S1. Pyrethroids and dimethyl sulfoxide are thoroughly stirred and dissolved in a closed stirring device, and then an emulsifier is added and stirred evenly to form an oil phase; S2. Control the temperature of the oil phase in the closed stirring device to 25~35℃, stir at a low speed of 120~200rpm, and slowly add deionized water at the same time. Transfer to an ultrasonic emulsifier for ultrasonic emulsification for 5~10min to obtain nanoemulsion. S3. Add the penetrant, antifreeze, and fragrance to the nanoemulsion and stir at low speed to mix well to obtain the drug solution; S4. The liquid medicine obtained in step S3 is metered, the valve is sealed, the propellant is filled, and the internal pressure range at a constant temperature of 55°C is tested to be 0.65MPa~0.80MPa. After weighing and water bath testing, the nozzle is installed to obtain a penetrating water-based insecticidal aerosol.

[0014] Preferably, the ultrasonic emulsification frequency is 20 kHz and the power density is 0.5~1.0 W / mL.

[0015] This invention relates to a penetrating water-based insecticidal aerosol. By using dimethyl sulfoxide to solubilize pyrethroids, the aerosol is further emulsified to form an oil-in-water (O / W) nanoscale emulsion, which is easy to spread and wet the surface of pests, improving penetration efficiency. The aerosol is composed of lipase and orange peel essential oil, which promotes the rapid dissolution of the waxy layer on the surface of pests, effectively penetrating the wax layer and enhancing the killing effect.

[0016] Compared with the prior art, the present invention has the following significant effects: (1) The present invention uses dimethyl sulfoxide to solubilize pyrethroids and then further emulsifies them to form an oil-in-water (O / W) nanoscale emulsion. This not only ensures stable storage, but also promotes the wetting and spreading of the aerosol on the waxy shell of the pest, so that the aerosol adheres to the surface of the pest after spraying, thereby improving the penetration efficiency.

[0017] (2) The aerosol formulation of this invention uses a penetrant composed of lipase and orange peel essential oil, which can effectively dissolve the wax on the surface of pests and effectively penetrate the insect shell. This not only reduces the amount of pesticide used but also reduces pollution to the home environment, leaves no oil stains, and avoids producing unpleasant odors.

[0018] (3) The penetrating water-based insecticidal aerosol of the present invention reduces the use of organic solvents and has the characteristics of rapid knockdown, high killing rate, low toxicity and environmental protection. Detailed Implementation

[0019] The following detailed description, in conjunction with embodiments, comparative examples, and aerosol efficacy evaluation, further illustrates this application. It should be noted that those skilled in the art can make various improvements or simple substitutions without departing from the principles of this invention, and these improvements or substitutions should also be considered within the scope of protection of this invention. The embodiments described are merely illustrative of the invention and should not be construed as specific limitations thereof. All raw materials involved in this application are commercially available. The production equipment employs an automated aerosol filling line.

[0020] The lipase used in the implementation plan has an enzyme activity of 30,000 u / g, a pH range of 4-9, and is readily soluble in water. It was provided by Weifang Ruichen Biotechnology Co., Ltd.

[0021] Example 1 S1. Dissolve 0.2% cis-cypermethrin, 0.2% permethrin, 0.1% methoxyfenozide and 1% dimethyl sulfoxide in a closed stirring apparatus according to the weight percentage, and then add 0.5% emulsifier polyoxyethylene sorbitan monooleate and stir evenly to form an oil phase; S2. The oil phase of the sealed stirring device was heated to 35°C and stirred at a low speed of 120 rpm. At the same time, 48% deionized water was slowly added. The mixture was then transferred to an ultrasonic emulsifier and emulsified for 10 min at a frequency of 20 kHz and a power density of 1.0 W / mL to obtain a nanoemulsion. The average particle size of the emulsion was (326.5 ± 24.4) nm by dynamic light scattering (DLS).

[0022] S3. Add 0.2% lipase, 0.2% orange peel essential oil, 2% antifreeze ethylene glycol, and 0.1% peppermint essence to the nanoemulsion, stir at low speed to mix well, and obtain the medicine solution; S4. The liquid obtained in step S3 is metered and bottled (the inside of the bottle is coated with a corrosion-resistant coating), the valve is sealed, and 47.5% propellant liquefied petroleum gas is filled in. The internal pressure at a constant temperature of 55°C is tested and found to be 0.70 MPa. After weighing and water bath testing, the nozzle is installed to obtain a penetrating water-based insecticidal aerosol.

[0023] Example 2 S1. Dissolve 0.4% ES bio-allethrin, 0.2% methoxyfenozide, 0.1% cis-cypermethrin and 1.2% dimethyl sulfoxide in a closed stirring apparatus according to the weight percentage. Then add 0.4% emulsifier polyoxyethylene sorbitan monooleate and 0.2% emulsifier polyoxyethylene sorbitan monopalmitate and stir evenly to form an oil phase. S2. The oil phase of the sealed stirring device was heated to 35°C and stirred at a low speed of 200 rpm. At the same time, 50% deionized water was slowly added. The mixture was then transferred to an ultrasonic emulsifier and emulsified for 5 min at a frequency of 20 kHz and a power density of 1.0 W / mL to obtain a nanoemulsion. The average particle size of the emulsion was (443.2 ± 20.6) nm by dynamic light scattering (DLS).

[0024] S3. Add 0.2% lipase, 0.3% orange peel essential oil, and 2% antifreeze propylene glycol to the nanoemulsion, stir at low speed to mix well, and obtain the drug solution; S4. The liquid obtained in step S3 is metered and bottled (the inside of the bottle is coated with a corrosion-resistant coating), the valve is sealed, and 45% liquefied petroleum gas is filled with propellant. The internal pressure at a constant temperature of 55°C is tested and found to be 0.72 MPa. After weighing and water bath testing, the nozzle is installed to obtain a penetrating water-based insecticidal aerosol.

[0025] Example 3 S1. Dissolve 0.3% methamidophos, 0.15% cis-cypermethrin, 0.15% deltamethrin and 1.5% dimethyl sulfoxide in a closed stirring apparatus according to the weight percentage, and then add 0.5% emulsifier polyoxyethylene sorbitan monostearate and stir evenly to form an oil phase; S2. The oil phase of the sealed stirring device was heated to 35°C and stirred at a low speed of 200 rpm. At the same time, 52% deionized water was slowly added. The mixture was then transferred to an ultrasonic emulsifier and emulsified for 10 min at a frequency of 20 kHz and a power density of 0.5 W / mL to obtain a nanoemulsion. The average particle size of the emulsion was (420.35±25.8) nm by dynamic light scattering (DLS).

[0026] S3. Add 0.2% lipase, 0.4% orange peel essential oil, and 2% antifreeze glycerol to the nanoemulsion, stir at low speed to mix well, and obtain the drug solution; S4. The liquid obtained in step S3 is metered and bottled (the inside of the bottle is coated with a corrosion-resistant coating), the valve is sealed, and 42.8% propellant compressed nitrogen is filled in. The internal pressure at a constant temperature of 55°C is measured to be 0.69 MPa. After weighing and water bath testing, the nozzle is installed to obtain a penetrating water-based insecticidal aerosol.

[0027] Comparative Example 1 The pesticide solution was prepared by dissolving 0.2% cis-cypermethrin, 0.2% permethrin, and 0.1% methoxyfenozide in 48% deionized water according to weight percentage. The solution was metered, bottled, and valve-sealed, then filled with 51.5% liquefied petroleum gas as propellant. The internal pressure was measured at a constant temperature of 55°C and found to be 0.75 MPa. After weighing and water bath testing, the solution was fitted with nozzles to obtain an oil-based insecticidal aerosol.

[0028] Comparative Example 2 In the formulation of Example 1, dimethyl sulfoxide was not used to pre-dissolve the pyrethroids; instead, deionized water was used. The remaining processes and raw material formulations were the same. The average particle size of the emulsion was determined to be (5672 ± 332) nm using dynamic light scattering (DLS).

[0029] The resulting emulsion has a larger particle size and reduced dissolution of the lipid layer, affecting its spread and infiltration on the insect exoskeleton, resulting in a lower half-knockout time (KT). 50 As the duration of the illness increased, the 24-hour mortality rate decreased.

[0030] Comparative Example 3 In the formulation of Example 1, lipase and orange peel oil were not used as penetrants; deionized water was used instead. The remaining processes and raw material formulations remained the same. The resulting aerosol had limited dissolution of lipids outside the insect exoskeleton, resulting in poorer permeability and a reduced half-maximum knockdown time (KT). 50 The duration of the illness increased, and the mortality rate within 24 hours decreased significantly.

[0031] Comparative Example 4 In the formulation of Example 1, the penetrant was 0.4% lipase, and the remaining processes and raw material formulations were the same. The resulting aerosol had a half-knock time KT. 50 The duration has increased slightly, but the 24-hour mortality rate remains unchanged.

[0032] Comparative Example 5 In the formulation of Example 1, the penetrant was 0.4% orange peel essential oil, and the remaining processes and raw material formulations were the same. The resulting aerosol had a half-knock time (KT). 50 The duration increased slightly, and the mortality rate decreased somewhat within 24 hours.

[0033] Evaluation of the efficacy of aerosol: Referring to the method in GB / T 13917.2-2025 (Indoor Efficacy Tests and Evaluation of Sanitary Insecticides for Pesticide Registration Part 2: Aerosols), the aerosols of Examples 1-3 and Comparative Examples 1-5 were used to conduct knockdown tests on mosquitoes and cockroaches, respectively. The dosage of pesticide sprayed in the cylinder was 1g, and the time KT for half of the insects to be knocked down was recorded. 50 (s), after 20 minutes, all test insects were collected into a container and fed according to standard. The number of deaths was checked after 24 hours, and the mortality rate was calculated. The mortality rate of cockroaches was further checked after 72 hours, as shown in Table 1.

[0034] Table 1: As demonstrated by the tests in the above examples and comparative examples, the nano-sized emulsion obtained by ultrasonic emulsification of the water-based insecticidal aerosol of the present invention through solubilization of pyrethroids with dimethyl sulfoxide exhibits good wetting, spreading, and penetrating properties on the waxy shells of mosquitoes and cockroaches under the synergistic effect of penetrants lipase and orange peel essential oil. It has significant knockdown and killing effects, comparable to the killing effect of oil-based insecticides (Comparative Example 1). As shown in Comparative Example 2, without the use of dimethyl sulfoxide to pre-dissolve pyrethroids, the resulting emulsion has a larger particle size (reaching the micrometer level), which affects the spreading and wetting of the emulsion on the shells of mosquitoes and cockroaches. Most significantly, as shown in Comparative Example 3, without the use of penetrants lipase and orange peel essential oil, the dissolution of the waxy shells of mosquitoes and cockroaches after spraying the aerosol is significantly reduced, and the knockdown and killing effects are significantly reduced.

Claims

1. A penetrating water-based insecticide aerosol, characterized in that, The permeable water-based insecticidal aerosol comprises, by weight percentage: 0.5-1.0% pyrethroids, 1-2% dimethyl sulfoxide, 0.5-1.0% emulsifier, 0.4-0.8% penetrant, 2-3% antifreeze, 0-0.5% fragrance, 40-50% propellant, and the balance being deionized water; wherein: The pyrethroid is a mixture of two or more of ES bio-allethrin, methamidophos, permethrin, cis-cypermethrin, cyhalothrin, and dextromethorphan in any proportion. The emulsifier is a nonionic surfactant with a hydrophilic-lipophilic balance value in the range of 10-18; The penetrant is composed of lipase and orange peel essential oil in a mass ratio of 1:(1~2).

2. The penetrating water-based insecticide aerosol according to claim 1, characterized in that, The pyrethroid is a mixture of ES bio-allethrin, methamidophos, and cis-cypermethrin in a mass ratio of 4:2:

1.

3. The penetrating water-based insecticide aerosol according to claim 1, characterized in that, The pyrethroid is a mixture of cis-cypermethrin, permethrin, and cypermethrin in a mass ratio of 2:2:

1.

4. The penetrating water-based insecticide aerosol according to claim 1, characterized in that, The pyrethroid is a mixture of pyrethroids, cis-cypermethrin, and cyhalothrin in a mass ratio of 2:1:

1.

5. The penetrating water-based insecticide aerosol according to claim 1, characterized in that, The emulsifier is at least one of polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan monostearate, and polyoxyethylene sorbitan monopalmitate.

6. The penetrating water-based insecticide aerosol according to claim 1, characterized in that, The lipase has an enzyme activity of ≥30000 u / g.

7. The penetrating water-based insecticide aerosol according to claim 1, characterized in that, The antifreeze is at least one of ethylene glycol, propylene glycol, and glycerol.

8. The penetrating water-based insecticide aerosol according to claim 1, characterized in that, The propellant is either compressed nitrogen or liquefied petroleum gas.

9. A method for preparing the penetrating water-based insecticidal aerosol according to any one of claims 1 to 8, characterized in that, The specific preparation method is as follows: S1. Pyrethroids and dimethyl sulfoxide are thoroughly stirred and dissolved in a closed stirring device, and then an emulsifier is added and stirred evenly to form an oil phase; S2. Control the temperature of the oil phase in the closed stirring device to 25~35℃, stir at a low speed of 120~200rpm, and slowly add deionized water at the same time. Transfer to an ultrasonic emulsifier for ultrasonic emulsification for 5~10min to obtain nanoemulsion. S3. Add the penetrant, antifreeze, and fragrance to the nanoemulsion and stir at low speed to mix well to obtain the drug solution; S4. The liquid medicine obtained in step S3 is metered, the valve is sealed, the propellant is filled, and the internal pressure range at a constant temperature of 55°C is tested to be 0.65MPa~0.80MPa. After weighing and water bath testing, the nozzle is installed to obtain a penetrating water-based insecticidal aerosol.

10. The method for preparing the penetrating water-based insecticidal aerosol according to claim 9, characterized in that, The ultrasonic emulsification was performed at a frequency of 20 kHz and a power density of 0.5~1.0 W / mL.

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