A targeted drug delivery device for releasing an anti-fibrotic drug

Abstract

The present application relates to the technical field of targeted drug delivery, and discloses a targeted drug delivery device for releasing anti-fibrosis drugs, which comprises a needle tube and a needle head mounted at one end of the needle tube, a piston end of a piston piece is seamlessly and slidably connected to the other end of the needle tube, a pressing plate is threadedly connected to a rod end of the piston piece, an annular tube is sleeved on the outside of the needle tube and connected to the outside of the needle tube through an elastic locking mechanism, the elastic locking mechanism comprises grooves arranged at equal angles on the outside of the needle tube, a visible window is arranged on the annular tube, and the annular tube is connected to the pressing plate through a uniform speed propulsion mechanism. The present application does not need to use a driving source such as a motor to consume electric energy, thereby reducing the limitations of use. In addition, the speed of drug delivery can be adjusted according to needs during use, which helps to improve the flexibility during use. In addition, the drug delivery device can be quickly disassembled and assembled, thereby facilitating replacement or cleaning and disinfection.

Description

Technical Field

[0001] This invention relates to the field of targeted drug delivery technology, specifically a targeted drug delivery device that releases an anti-fibrotic drug. Background Technology

[0002] With the increasing aging of the global population and changes in lifestyle, heart disease has become one of the leading causes of death threatening human health. Among them, myocardial fibrosis, as a core pathological link in the progression of many heart diseases, seriously affects the stability of cardiac structure and systolic and diastolic functions. It is a key factor leading to ventricular remodeling, deterioration of cardiac function and poor long-term prognosis. At present, there is no ideal treatment that can effectively reverse or precisely inhibit the process of myocardial fibrosis. The research and application of antifibrotic drugs have provided a new direction for the treatment of myocardial fibrosis. However, their clinical efficacy is limited by the inherent defects of traditional administration methods, making it difficult to achieve precise targeting of the heart lesion site. Under traditional oral or intravenous administration methods, the drug needs to be distributed through the blood circulation throughout the body. Affected by the first-pass effect of the liver, blood dilution, and the physiological barrier of the heart, only a very small portion of the drug can reach the myocardial lesion area to exert its effect, resulting in a mismatch between the therapeutic dose and the efficacy. In order to achieve the expected therapeutic effect, it is often necessary to increase the dosage. This not only reduces the drug utilization efficiency, but also causes the drug to accumulate in large quantities in non-target organs such as the liver and kidneys, causing serious systemic toxic side effects, which greatly limits the clinical translation and application of antifibrotic drugs in the treatment of heart disease. To address the aforementioned issues, cardiac targeted drug delivery technology has emerged. Its core objective is to construct a dedicated device capable of precisely delivering anti-fibrotic drugs to the site of myocardial lesions, achieving specific binding between the drug and cardiac tissue, and breaking through the bottlenecks of traditional drug delivery methods. Compared with traditional drug delivery methods, targeted drug delivery devices for releasing anti-fibrotic drugs in the heart have significant advantages, providing a precise solution for the treatment of myocardial fibrosis. Existing targeted drug delivery devices for releasing antifibrotic drugs, such as the one announced in CN209075825U, which is a distal coronary drug delivery device via a targeted perfusion catheter, can simultaneously inhale two drugs and can infuse the drugs one by one during use, thus solving the problem of frequently changing syringes. However, the aforementioned existing technologies rely on motor control, which limits their application and makes them inconvenient to use anytime and anywhere. In addition, the existing technologies are not convenient for adjusting the drug delivery speed, because most motors do not have the function of adjusting the speed. They need to rely on corresponding electronic components to achieve the purpose of adjusting the speed. This will require adding too many complex structures to the existing technologies, which will reduce the reliability of use and make them unsuitable for use. Therefore, a targeted drug delivery device that releases antifibrotic drugs is needed to solve the above problems. Summary of the Invention

[0003] The purpose of this invention is to provide a targeted drug delivery device for releasing antifibrotic drugs, thereby solving the problems mentioned in the background art, such as the inconvenience of adjusting the amplitude of existing wave compensation test benches and the insufficient reference value of detection based solely on oscillation.

[0004] To achieve the above objectives, the present invention provides the following technical solution: A targeted drug delivery device for releasing an anti-fibrotic drug includes a needle tube and a needle tip installed at one end thereon. The piston end of a piston component is seamlessly slidably connected to the inner side of the opening at the other end of the needle tube, and a pressure plate is threadedly connected to the rod end of the piston component. An annular tube is sleeved on the outer side of the needle tube, and the annular tube is connected to the outer side of the needle tube through an elastic locking mechanism. The elastic locking mechanism includes grooves equally spaced on the outer side of the needle tube. A viewing window is provided on the annular tube, and the annular tube is connected to the pressure plate through a uniform speed advancing mechanism. The uniform speed advancing mechanism includes a piston ring seamlessly slidably connected inside the annular tube.

[0005] Preferably, the elastic locking mechanism further includes a locking block axially connected in each groove, and locking beads are installed on the outer sides of both ends of the locking block. The inner side of the locking block at the end away from the needle is connected to the inner side of the corresponding groove through an elastic sheet.

[0006] Preferably, a support ring is sleeved on the outer side of the needle tube, and the support ring is located between two locking beads on the locking block. The inner side of the end of the ring tube and the inner side of the support ring are both provided with an embedded groove that matches the locking beads. A pressure ring is provided on the part of the support ring located in the groove. The pressure ring is sleeved on the outer side of the corresponding locking block, and a wedge block is provided on the side of the locking block facing the inner side of the groove. The shape of the part of the pressure ring corresponding to the wedge block matches the wedge block.

[0007] Preferably, the uniform speed propulsion mechanism further includes a support tube disposed at equal angles on the piston ring, and the support tube is disposed through the ring tube in a sealed manner. The piston ring is provided with a one-way liquid inlet hole and a one-way liquid outlet hole at equal angles. The inside of the ring tube is filled with oil. All the ends of the support tubes located outside the ring tube are connected by a top support ring.

[0008] Preferably, the one-way liquid inlet and one-way liquid outlet have opposite directions of conduction, and the diameter of the one-way liquid inlet is not less than three times that of the one-way liquid outlet.

[0009] Preferably, the uniform speed propulsion mechanism further includes a support ring and a connecting ring disposed above the annular tube, and the upper surface of the annular tube is connected to the support ring through support blocks distributed at equal angles. Each support tube has a shaft passing through it through a sealed bearing, and the upper ends of all shafts are distributed at equal angles on the lower surface of the connecting ring. A spring is disposed between the lower surface of the connecting ring and the upper surface of the support ring.

[0010] Preferably, the upper surface of the connecting ring is axially connected to one end of the locking buckle, and the upper surface of the connecting ring is also fixedly connected to a locking frame.

[0011] Preferably, the latch has an n-shaped structure, and the other end of the latch is provided with a hook-shaped structure for fastening to the lock frame, and the other end of the latch is a flexible metal structure.

[0012] Preferably, the uniform speed propulsion mechanism further includes a retaining ring connected to the lower surface of the piston ring via a sealed bearing, and the retaining ring is provided with a convex plate. The lower end of the shaft extends to the lower surface of the piston ring, and the lower end of the shaft is keyed to a drive gear, which meshes with the retaining ring.

[0013] Preferably, the uniform speed propulsion mechanism further includes an adjusting ring connected to the upper surface of the support ring by a bearing, and an adjusting gear is keyed to the outer side of the upper end of the shaft, and the adjusting gear is meshed with the inner side of the adjusting ring.

[0014] Compared with the prior art, the beneficial effects of the present invention are: the targeted drug delivery device for releasing antifibrotic drugs does not require the use of an energy-consuming drive source such as a motor to inject antifibrotic drugs into the myocardial lesion site, thereby reducing the limitations of use; in addition, the drug delivery rate can be adjusted as needed during use to avoid injecting antifibrotic drugs into the myocardial lesion site too quickly or too slowly, which helps to improve the flexibility of use; furthermore, the drug delivery device can be quickly disassembled and assembled, thus facilitating replacement or cleaning and disinfection. 1. The elastic potential energy generated by the stretching of the spring, the oil-containing ring tube, and the piston ring with one-way inlet and one-way outlet holes enable the piston to be slowly and smoothly pushed into the syringe, thus enabling slow and stable drug delivery. During the process, there is no need to use a power-consuming drive source such as a motor to inject anti-fibrotic drugs into the myocardial lesion site, which makes it convenient to use at any location and any time. This not only helps to save energy and reduce emissions, but also reduces the limitations of use. 2. By rotating the adjusting ring, the meshing adjusting gear rotates, which in turn rotates the retaining ring via the shaft and drive gear. When the retaining ring rotates, it changes the number of one-way drainage holes on the piston ring that allow oil to flow through, thereby changing the speed at which the piston ring moves within the ring tube. In other words, it changes the speed at which the piston is pushed into the syringe, allowing the user to adjust the drug delivery speed as needed. This avoids injecting antifibrotic drugs into the myocardial lesion site too quickly or too slowly. Compared to the previous method of using multiple electronic components to change the motor speed, this method of adjusting the drug delivery speed by rotating the adjusting ring is more reliable and can relatively reduce the likelihood of failure during use. 3. The piston and pressure plate are connected by threads, and the locking buckle and locking frame are designed to facilitate the fitting of the ring tube and its connected components onto the outside of the needle tube. It also facilitates the installation of the pressure plate between the locking buckle and the connecting ring, so that the pressure plate and its connected piston can move synchronously with the connecting ring. In addition, the elastic locking mechanism allows the ring tube to be quickly and securely connected to the needle tube, ensuring that the two will not move relative to each other during use. When it is necessary to separate the needle tube and the ring tube, only pushing is required. Attached Figure Description

[0015] Figure 1 This is a schematic diagram of the main structure of the present invention; Figure 2 This is a schematic diagram of the connection structure between the needle tube and the pressure plate of the present invention; Figure 3 This is a partial cross-sectional view of the connection between the ring tube and the needle tube of the present invention; Figure 4 For the present invention Figure 3 Enlarged structural diagram of point A in the middle; Figure 5 This is a schematic diagram of the ring tube and locking connection structure of the present invention; Figure 6 For the present invention Figure 5 Enlarged structural diagram of point B; Figure 7 This is a bottom view of the connection structure between the piston ring and the retaining ring of the present invention; Figure 8 This is a schematic diagram of the piston ring and locking connection structure of the present invention.

[0016] In the diagram: 1. Ring tube; 2. Viewing window; 3. Support block; 4. Support ring; 5. Support ring; 6. Needle; 7. Pressure plate; 8. Connecting ring; 9. Lock; 10. Needle tube; 11. Piston; 12. Support tube; 13. Spring; 14. Shaft; 15. Groove; 16. Locking block; 17. Locking ball; 18. Elastic sheet; 19. Support ring; 20. Adjusting ring; 21. Piston ring; 22. One-way inlet hole; 23. One-way outlet hole; 24. Retaining ring; 25. Drive gear; 26. Adjusting gear; 27. Lock frame; 28. Pressure ring; 29. ​​Wedge block. Detailed Implementation

[0017] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0018] Please see Figures 1-8 The present invention provides the following technical solution: Example 1: To address the problem that conventional targeted drug delivery devices require power-consuming drive sources such as motors to stably and slowly inject drugs into patients, thus increasing limitations during use, the following technical solution is provided: a targeted drug delivery device for releasing anti-fibrotic drugs, comprising a needle tube 10 and a needle 6 installed at one end thereon. The piston end of a piston component 11 is seamlessly slidably connected to the inner side of the opening at the other end of the needle tube 10, and a pressure plate 7 is threadedly connected to the rod end of the piston component 11. An annular tube 1 is sleeved on the outer side of the needle tube 10, and the annular tube 1 is connected to the outer side of the needle tube 10 through an elastic locking mechanism. The elastic locking mechanism includes grooves 15 equally angled on the outer side of the needle tube 10. A viewing window 2 is provided on the annular tube 1, and the annular tube 1 is connected to the pressure plate 7 through a uniform speed propulsion mechanism. The uniform speed propulsion mechanism includes a piston ring 21 seamlessly slidably connected inside the annular tube 1.

[0019] The elastic locking mechanism also includes a locking block 16 axially connected in each groove 15, and locking beads 17 are installed on the outer sides of both ends of the locking block 16. The inner side of the locking block 16 away from the needle 6 is connected to the inner side of the corresponding groove 15 through an elastic sheet 18. A support ring 5 is sleeved on the outer side of the needle tube 10, and the support ring 5 is located between the two locking beads 17 on the locking block 16. The inner side of the end of the ring tube 1 and the inner side of the support ring 5 are provided with an embedded groove that matches the locking beads 17. A pressure ring 28 is provided on the part of the support ring 5 located in the groove 15. The pressure ring 28 is sleeved on the outer side of the corresponding locking block 16. A wedge block 29 is provided on the side of the locking block 16 facing the inner side of the groove 15. The shape of the corresponding part of the pressure ring 28 matches the wedge block 29.

[0020] according to Figures 1-4 When in use, rotate the pressure plate 7 to separate the pressure plate 7 from the piston 11. After the two are separated, put the ring tube 1 on the outside of the needle tube 10. During the process, piston component 11 will also penetrate the annular tube 1, and piston component 11 will also penetrate the connecting ring 8; As the ring tube 1 is gradually fitted onto the outside of the needle tube 10, one of the two locking beads 17 on the locking block 16 will gradually engage into the corresponding inner groove on the ring tube 1, thereby fixing the ring tube 1 to the outside of the needle tube 10. Then, the pressure plate 7 is re-threaded to the piston 11, and the latch 9 is rotated so that the latch 9 elastically engages with the lock frame 27, thereby fixing the pressure plate 7 between the connecting ring 8 and the latch 9.

[0021] The uniform speed propulsion mechanism also includes support tubes 12 that are equally angled on the piston rings 21, and the support tubes 12 are sealed and movable through the ring tube 1. One-way inlet holes 22 and one-way outlet holes 23 are equally angled on the piston rings 21. The inside of the ring tube 1 is filled with oil. All the ends of the support tubes 12 located outside the ring tube 1 are connected by a support ring 19. The one-way inlet holes 22 and one-way outlet holes 23 have opposite directions of conduction, and the diameter of the one-way inlet hole 22 is not less than three times that of the one-way outlet hole 23. The uniform speed propulsion mechanism also includes a support ring 4 and a connecting ring 8 located above the ring tube 1. The upper surface of 1 is connected to the support ring 4 by support blocks 3 distributed at equal angles. Each support tube 12 has a shaft 14 passing through it through a sealed bearing. All shafts 14 have bearings distributed at equal angles on the lower surface of the connecting ring 8. A spring 13 is provided between the lower surface of the connecting ring 8 and the upper surface of the support ring 4. One end of the latch 9 is axially connected to the upper surface of the connecting ring 8. A locking frame 27 is also fixedly connected to the upper surface of the connecting ring 8. The latch 9 has an n-shaped structure. The other end of the latch 9 has a hook-shaped structure for locking onto the locking frame 27. The other end of the latch 9 is an elastic metal structure.

[0022] according to Figures 1-2 When in use, pulling the outer connecting ring 8 causes the pressure plate 7 and piston 11 to move synchronously, thereby drawing in the medicine through the needle 6; During the process, the spring 13 is stretched, thereby generating elastic potential energy, and when the connecting ring 8 moves, the piston ring 21 moves inside the ring tube 1, and the oil in the ring tube 1 flows through the one-way inlet hole 22. Then insert the needle 6 into the corresponding position and release the connecting ring 8. At this time, under the reset action of the spring 13, the connecting ring 8, the pressure plate 7 and the piston 11 are gradually reset. During the process, the piston ring 21 is also gradually reset in the ring tube 1. During the process, the oil in the ring tube 1 will flow in the opposite direction through the one-way drain hole 23. By allowing the oil to flow in the reverse direction within the ring tube 1, the connecting ring 8, pressure plate 7, and piston 11 can be reset at a stable and nearly constant speed, thereby ensuring that the liquid medicine in the syringe 10 is injected into the designated position in a stable and slow manner. The above process does not require the use of a motor or other power-consuming drive source, thus facilitating use at any location and time and helping to reduce limitations in its use.

[0023] Example 2: To solve the problem in Example 1 that the targeted drug delivery device cannot adjust the drug delivery speed, the following technical solution is provided: Specifically, the uniform speed propulsion mechanism further includes a retaining ring 24 connected to the lower surface of the piston ring 21 via a sealed bearing, and the retaining ring 24 is provided with a convex plate. The lower end of the shaft 14 extends to the lower surface of the piston ring 21, and the lower end of the shaft 14 is keyed to a drive gear 25, which meshes with the retaining ring 24.

[0024] The uniform speed propulsion mechanism also includes an adjusting ring 20 connected to the upper surface of the support ring 19 by a bearing, and an adjusting gear 26 is keyed to the outer side of the upper end of the shaft 14, and the adjusting gear 26 is meshed with the inner side of the adjusting ring 20.

[0025] according to Figures 5-8 When the adjusting ring 20 is rotated, it meshes with the adjusting gear 26, which enables the adjusting gear 26 to drive the shaft 14 to rotate. When the shaft 14 rotates, the drive gear 25 connected to its end rotates synchronously, and then drives the retaining ring 24 to rotate through meshing with the retaining ring 24. When the retaining ring 24 rotates, the convex plate on it will gradually block the one-way drain hole 23, which will reduce the number of one-way drain holes 23 on the piston ring 21 that can flow oil, thereby gradually reducing the speed at which the piston ring 21 moves in the ring tube 1. By changing the speed at which the piston ring 21 moves within the ring tube 1, the speed at which the piston 11 advances within the needle tube 10 can be altered. This allows for adjustments to the drug delivery speed based on usage requirements, thereby increasing the flexibility of the drug delivery device.

[0026] The contents not described in detail in this specification are existing technologies known to those skilled in the art.

[0027] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A targeted drug delivery device for releasing an antifibrotic drug, comprising a needle (10) and a needle tip (6) attached to one end thereof, characterized in that: The piston end of the piston component (11) is seamlessly slidably connected to the inner side of the opening at the other end of the needle tube (10), and the rod end of the piston component (11) is threadedly connected to the pressure plate (7). A ring tube (1) is sleeved on the outer side of the needle tube (10), and the ring tube (1) is connected to the outer side of the needle tube (10) through an elastic locking mechanism. The elastic locking mechanism includes a groove (15) set at an equal angle on the outer side of the needle tube (10). A viewing window (2) is provided on the ring tube (1), and the ring tube (1) is connected to the pressure plate (7) through a uniform speed pushing mechanism. The uniform speed pushing mechanism includes a piston ring (21) seamlessly slidably connected inside the ring tube (1).

2. The targeted drug delivery device for releasing anti-fibrotic drugs according to claim 1, characterized in that: The elastic locking mechanism also includes a locking block (16) axially connected in each groove (15), and locking beads (17) are installed on the outer sides of both ends of the locking block (16). The inner side of the locking block (16) away from the needle (6) is connected to the inner side of the corresponding groove (15) through an elastic sheet (18).

3. The targeted drug delivery device for releasing anti-fibrotic drugs according to claim 2, characterized in that: The needle tube (10) is fitted with a support ring (5) on its outer side, and the support ring (5) is located between two lock beads (17) on the lock block (16). The inner side of the end of the ring tube (1) and the inner side of the support ring (5) are both provided with an embedded groove that matches the lock beads (17). The support ring (5) is provided with a pressure ring (28) at the part of the groove (15). The pressure ring (28) is fitted on the outer side of the corresponding lock block (16), and a wedge block (29) is provided on the side of the lock block (16) facing the inner side of the groove (15). The shape of the part of the pressure ring (28) corresponding to the wedge block (29) matches the wedge block (29).

4. A targeted drug delivery device for releasing antifibrotic drugs according to claim 3, characterized in that: The uniform speed propulsion mechanism also includes a support tube (12) set at equal angles on the piston ring (21), and the support tube (12) is sealed and movable through the ring tube (1). The piston ring (21) is provided with a one-way liquid inlet hole (22) and a one-way liquid outlet hole (23) at equal angles. The inside of the ring tube (1) is filled with oil. The ends of all the support tubes (12) located outside the ring tube (1) are connected by a top support ring (19).

5. A targeted drug delivery device for releasing an anti-fibrotic drug according to claim 4, characterized in that: The one-way inlet hole (22) and the one-way outlet hole (23) have opposite directions of conduction, and the diameter of the one-way inlet hole (22) is not less than three times that of the one-way outlet hole (23).

6. A targeted drug delivery device for releasing an anti-fibrotic drug according to claim 5, characterized in that: The uniform speed propulsion mechanism also includes a support ring (4) and a connecting ring (8) disposed above the ring tube (1). The upper surface of the ring tube (1) is connected to the support ring (4) through support blocks (3) distributed at equal angles. Each support tube (12) has a shaft (14) passing through it through a sealed bearing. All shafts (14) have equal angle bearings distributed on the lower surface of the connecting ring (8). A spring (13) is disposed between the lower surface of the connecting ring (8) and the upper surface of the support ring (4).

7. A targeted drug delivery device for releasing an anti-fibrotic drug according to claim 6, characterized in that: The upper surface of the connecting ring (8) is axially connected to one end of the buckle (9), and the upper surface of the connecting ring (8) is also fixedly connected to the locking frame (27).

8. A targeted drug delivery device for releasing an anti-fibrotic drug according to claim 7, characterized in that: The latch (9) has an n-shaped structure, and the other end of the latch (9) is provided with a hook-shaped structure for fastening to the lock frame (27). The other end of the latch (9) is an elastic metal structure.

9. A targeted drug delivery device for releasing an anti-fibrotic drug according to claim 8, characterized in that: The uniform speed propulsion mechanism also includes a retaining ring (24) connected to the lower surface of the piston ring (21) via a sealed bearing, and a convex plate is provided on the retaining ring (24). The lower end of the shaft (14) extends to the lower surface of the piston ring (21), and a drive gear (25) is keyed to the lower end of the shaft (14). The drive gear (25) meshes with the retaining ring (24).

10. A targeted drug delivery device for releasing an anti-fibrotic drug according to claim 9, characterized in that: The uniform speed propulsion mechanism also includes an adjusting ring (20) that is connected to the upper surface of the support ring (19) by a bearing. An adjusting gear (26) is keyed to the outer side of the upper end of the shaft (14), and the adjusting gear (26) is meshed with the inner side of the adjusting ring (20).

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