Preparation for application to the skin, mild to the skin and having nourishing and protective effects

Abstract

The present invention relates to a preparation for application to the skin or for skin care, which is mild to the skin and has a nourishing and protective effect, comprising one or more active ingredients, in particular but not exclusively plant extracts or oils.

Description

Technical Field

[0001] The present invention relates to preparations for application to the skin or for skin care as described in the preamble of claim 1, which are gentle on the skin and have nourishing and protective effects, comprising one or more active ingredients, particularly but not limited to plant extracts or oils. Background Technology

[0002] As is well known, there are products that can be applied to the skin. When applied to the skin, they not only provide skincare benefits but also disinfect and reduce bacteria. These formulations typically use isopropanol, ethanol, or other alcohols as their active ingredients.

[0003] For example, preparations known for use in skin care and antimicrobial treatment of the skin are listed in EP 1 955 591 A1.

[0004] Utility model DE 20 2020 104 615 U1 is a skin-applied disinfectant with skin-friendly, nourishing, and moisturizing properties. The formulation contains one or more disinfectant active ingredients, characterized in that a water-soluble chlorine derivative and / or alcohol are incorporated into the matrix, and additionally, a mixture is added to mask the odor of the specific disinfectant.

[0005] From a medical perspective, creams or lotions refer to oil-in-water or water-in-oil emulsions, which make the ingredients easy to apply. Compared to ointments, creams have a lower viscosity, meaning they are thinner and penetrate the skin more effectively. Emulsifiers or lotion stabilizers are frequently used in creams. In everyday language, they are increasingly referred to as non-medical products, i.e., purely skincare products.

[0006] Manufacturers often promise soothing effects for commercially available topical skin products. These products typically contain blends of plant oils or extracts that have physiological benefits. Formulations containing 2-(3-methyl-6-propylbenzodioxane-5-yl)cyclohexyl-1,3-dien-1-ol (Cannabidiol CBD) are also widely known.

[0007] Typical examples of such products include Bioturm Naturkosmetik CBD ointment, Wobcare CBD active cream, Rubaxx Cannabis CBD gel, Venostasin gel, and Beinwell cream from the Benedictine Order of Bijon.

[0008] These products offer only the corresponding active ingredient or a combination of active ingredients in one dosage form (such as ointment, gel, or cream).

[0009] Based on the above, the purpose of this invention is to provide an improved, skin-friendly formulation with care and protection effects for application or skin care. In addition to pursuing good skin tolerance and soothing effects, this formulation can be formulated into various dosage forms for sale, thus enabling rapid response to customer needs while retaining the active ingredients and possible additional functional and supplementary additives, and exhibiting particularly good compatibility with skin damaged by neurodermatitis or psoriasis. Summary of the Invention

[0010] The solution of the present invention is achieved by a formulation that is gentle on the skin and has a caring and protective effect according to claim 1, wherein the dependent claims at least represent a suitable design and improvement.

[0011] Therefore, depending on the desired form of administration and delivery, a stock of active ingredient mixtures can be incorporated into a carrier matrix. The carrier matrix can be formulated as a cream, lotion or ointment, gel matrix, or alcohol-based cream.

[0012] Creams can be formulated with either water or oil.

[0013] Alcohol-based creams are a mixture of alcohol-based gels and oil-based creams.

[0014] Functional additives may be added to the effective material base mixture.

[0015] Such functional or complementary additives can be fragrances, dyes, odor-masking substances, fillers, thickeners, humectants, and / or UV protectants.

[0016] The carrier matrix can be based on commercially available base creams or hydrophilic ointments.

[0017] However, the carrier matrix can also contain hydrophilic gels or lipophilic gels.

[0018] The active ingredient mixture contains 2-(3-methyl-6-propylbenzodioxane-5-yl)cyclohexyl-1,3-dien-1-ol (Cannabidiol CBD) ), essential oils and / or plant extracts.

[0019] For carrier matrices based on gels or alcohol-containing creams, additional alcohol can be added to enhance bactericidal and disinfecting effects.

[0020] Based on a blend of effective ingredients, this gentle and caring formulation can be provided as a lipid- or oil-based cream or ointment, a water- and / or alcohol-based gel, or an alcohol-containing cream with a high fat or oil content and a high alcohol content.

[0021] Therefore, the corresponding formulation consists of at least a carrier matrix, an active ingredient, and supplementary additives, which may have functional effects and are selected according to the intended use.

[0022] These functional or supplementary additives can be fragrances or dyes, odor-masking substances or fillers, and also include substances such as urea to achieve additional moisturizing effects. Similarly, if the formulation is intended to be used as a UV protectant, UV absorbers or UV blockers / UV protectants can be added.

[0023] To provide different dosage forms, only the carrier matrix needs to be changed or modified while keeping the active ingredients and selected functional or supplementary additives the same.

[0024] The various dosage forms of the preparation should be described and defined as follows.

[0025] According to the definition of this invention, a cream is a preparation based on oil and water. Water-based creams belong to the category of oil-in-water emulsions. Oil-based creams are water-in-oil emulsions. Oil-in-water creams can achieve a cooling effect.

[0026] Ointments are lipid-based substances. According to the pharmaceutical definition, unlike creams, ointments do not contain water, but depending on their ingredients, they can absorb moisture.

[0027] Here, a gel is defined as a finely dispersed system consisting of at least one solid phase and at least one liquid phase. The solid phase (e.g., a polymer) forms a sponge-like three-dimensional network whose pores can be filled with a liquid (e.g., alcohol and / or water) or a gas. The two phases are completely interpenetrating.

[0028] Alcohol-containing creams are formulas similar to traditional creams, containing oils and water, but also a high amount of alcohol.

[0029] In commercially available creams, the alcohol content is limited to a relatively low percentage due to manufacturing processes. The alcohol-containing cream used in this invention is a combination of an alcohol-containing gel and a lipid-based cream, wherein the alcohol content can be as high as 70% or more, thereby improving the disinfection effect.

[0030] The present invention will be described in detail below through an embodiment. Detailed Implementation

[0031] Preparations that are gentle on the skin and have nourishing and protective effects consist of the following ingredients or components:

[0032] 1. Carrier matrix:

[0033] Depending on the required dosage form, the carrier matrix may be composed of different substances or have different compositions, as detailed below:

[0034] a. Cream or ointment carrier base:

[0035] Therefore, commercially available base creams for making lotions, sold in pharmacies, can be used. Depending on the manufacturer's datasheet and formula, they contain the following ingredients:

[0036] DAC Basic Cream: Glyceryl monostearate 60, cetyl alcohol, medium-chain triglycerides (neutral oil, Miglyol 812), white petrolatum, polyethylene glycol 20 glyceryl monostearate, propylene glycol, purified water.

[0037] Lanolin DAB: Composed of wool wax, purified water, and virgin olive oil.

[0038] DAC hydrophilic emulsion: composed of sorbitan monostearate type I, polyethylene glycol 8-stearate type I, 85% glycerol, medium-chain triglycerides, citric acid, potassium sorbate, and purified water.

[0039] DAC Hydrophobic Base Cream: Composed of glyceryl diisostearate, isopropyl palmitate, paraffin oil, polyethylene, potassium sorbate, citric acid, magnesium sulfate, 85% glycerin, and purified water.

[0040] DAB hydrophilic ointment: composed of viscous paraffin, petrolatum, and the emulsifier cetearyl alcohol.

[0041] b. Gel carrier matrix:

[0042] The gel matrix can be a hydrophilic gel, for example, composed of: a gelling agent (such as carbomer), a cellulose derivative (such as hydroxyethyl cellulose, carboxymethyl cellulose, hydroxypropyl methyl cellulose or methyl cellulose) or a polysaccharide (such as alginate, agar, xanthan gum, guar gum or guar gum), and propylene glycol, glycerol, ethanol, sodium EDTA, thiamethoxam and / or purified water.

[0043] Lipophilic gels can also be used as a matrix, for example, a mixture of viscous paraffin wax with polyethylene or neutral oil and thickeners (such as zinc stearate, aluminum stearate, highly dispersed silica or ethyl cellulose).

[0044] c. Alcohol-containing cream carrier matrix:

[0045] Here, a hydrogel may be used as a base, such as one composed of carbomer or other gelling agents mentioned in 1b, purified water and ethanol, to which a neutral oil or emulsion, such as the base cream or other cream or ointment in 1.a, is added.

[0046] 2. Active ingredients:

[0047] Various substances that work on the skin can be used as active ingredients. These can be plant extracts or oils, or synthetic substances.

[0048] A typical example is the combination of CBD with St. John's wort and arnica essential oils.

[0049] In addition, it is worth mentioning the combination of CBD oil, extracts or isolates with ingredients such as menthol and camphor.

[0050] You can also use CBD-free formulas, such as essential oils, alcohol extracts and isolates of star anise, arnica, cayenne pepper, frankincense, parsley, cloves, cinnamon, eucalyptus, fennel, lavender, lemon, chamomile, tea tree, bee balm, arnica, cannabis, St. John's wort, spruce, pine needles, rosemary, thyme, etc., as well as combinations thereof.

[0051] 3. Functional and supplementary additives:

[0052] a. Dye:

[0053] The dyes can be β-carotene, riboflavin, carmine, curcumin, purple pigment, patent blue V, gold, titanium dioxide, iron oxide, and mica.

[0054] b. Fragrance:

[0055] This can be essential oils, such as rose essential oil, lavender essential oil, and mixtures of various essential oils.

[0056] c. Substances that mask odors:

[0057] This invention uses commercially available mixtures to mask odors. Two examples of the composition of such products are listed below, with ingredient information from the manufacturer's datasheet:

[0058] Mixture A consists of: 2,6-dimethyloctyl-7-en-2-ol, 3,7-dimethyloctane-3-ol, 1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthyl)ethane-1-one, phenylpentanol, β-methylisopentyl salicylate, 3-(p-ethylphenyl)-2,2-dimethylpropanal, 3,7-dimethyloctane-3-yl acetate, β-phenylpropanol, 3- Trimethyl-2-phenylethanol, anisaldehyde, (E)-4-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3-buten-2-one, oxetane-hexadecene-2-one, piperaldehyde, 1,4-dioxane-heptadecane-5,17-dione, pentadecane-15-lactone, hexyl acetate, 3-(o-ethylphenyl)-2,2-dimethylpropanal, 1-methyl-4-(4-methylpentyl)cyclohex-3-ene-1-carboxaldehyde.

[0059] Component B of mixture:

[0060] Hexyl salicylate, 3,7-dimethyloctyl-3-ol, 1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthyl)ethane-1-one, 2H-pyran-4-ol, tetrahydro-4-methyl-2-(2-methylpropyl)-, β-methylphenylpentanol, β-3-trimethylphenylpropanol, pentadecane-15-lactone, 2,6-dimethyloctyl-7-en-2-ol, α-methyl-1,3-benzodioxane-5-propanal, 4-(4-methyl-3-pentenyl)cyclohex-3-en-1-carboxaldehyde, (E)-anesinol, 2-ethyl-4-(2,2,3-trimethyl-3-cyclopenten- 1-yl)-2-buten-1-ol, 1,2,3,5,6,7-hexahydro-1,1,2,3,3-pentamethyl-4H-indene-4-one, 3-(p-ethylphenyl)-2,2-dimethylpropanal, anisole (MUGETANOL), piperaldehyde, oxacyclohexaeno-2-one, 4-methyl-3-decen-5-ol, 3-(o-ethylphenyl)-2,2-dimethylpropanal, allylcyclohexyloxy)acetate, methyl 2,4-dihydroxy-3,6-dimethylbenzoate, 2,6-dimethylheptyl-5-enal, octahydro-7-methyl-1,4-bridged methylenenaphthalene-6(2H)-one, cis-hex-3-en-1-ylmethyl carbonate.

[0061] d. Fillers and / or thickeners:

[0062] Glycerin, propylene glycol, paraffin, starch or starch derivatives, titanium dioxide, zinc oxide; polyacrylates, cellulose derivatives, polyvinylpyrrolidone or copolymers of these compounds.

[0063] e. Functional additives:

[0064] For additional benefits, ingredients such as urea can be added to the formula. This gives the product extra moisturizing properties. For example, adding a UV blocker like titanium dioxide to the formula allows it to be used as a sunscreen. The SPF depends on the concentration of titanium dioxide. If a gel or alcohol-based cream is used as a carrier base, additional alcohol, such as ethanol, can be added to the mixture, up to 70% or more. This achieves a sterilization effect.

[0065] A commercially available topical skin ointment is made by mixing the above components in different proportions. It must contain components 1 and 2, and, if necessary, component 3.

[0066] Depending on the dosage form, the formulations described in this invention can be offered and sold in appropriate containers or packaging. Dispensers, cans, tubes, or similar containers may be used for this purpose.

[0067] The formulation described in this invention is particularly suitable for use as a hand cream, applied to the skin in a conventional manner to achieve the desired care and disinfection effects.

[0068] The formulation described in this invention consists of the components and their proportions listed in the table below:

[0069] In making and processing the cream, almond oil is added first, followed by cetyl alcohol, and if necessary, polydextrose, CBD isolate, and vitamin E / tocopherol. The resulting mixture is then stirred and heated at a temperature between 60°C and 80°C until completely dissolved.

[0070] Heat the prescribed amount of sea salt at a temperature of approximately 160°C to 180°C for at least 1 hour.

[0071] Then, dissolve the sea salt in purified water, and add xanthan gum and propylene glycol while stirring.

[0072] Combine the two mixtures and heat them to between 60°C and 80°C with stirring, then emulsify for about 10 to 20 minutes.

[0073] The formulation has a particularly beneficial effect on skin damaged by neurodermatitis or psoriasis.

[0074] The use of the main active ingredients in the formula, namely CBD and Dead Sea bath salts, contributed to the success of this invention.

[0075] The CBD content in the formula ranges from 0.5% to 3%, with 1% being particularly beneficial. The Dead Sea bath salt content ranges from 3% to 9%, with approximately 8% being particularly beneficial.

Claims

1. A preparation applied to the skin or used for skin care, which is gentle on the skin and has nourishing and protective effects, comprising one or more active ingredients, particularly but not limited to plant extracts or oils, characterized in that, A first mixture is provided, comprising at least almond oil, cetyl alcohol, CBD isolate, and vitamin E or tocopherol; a second mixture is provided, comprising sea salt, xanthan gum, and propylene glycol dissolved in purified water, wherein the first mixture and the second mixture are mixed and emulsified.

2. The skin-mild formulation according to claim 1, Its features are, The primary active ingredient is CBD isolate, and the secondary active ingredient is sea salt.

3. The skin-friendly formulation according to claim 2, Its features are, The mixture contains 0.5% to 3% CBD isolate and 3% to 9% sea salt.

4. The skin-mild formulation according to any one of the preceding claims, characterized in that, The mixture contains 5 to 10 grams of cetyl alcohol, 15 to 40 grams of almond oil, 0.25 to 1.5 grams of xanthan gum, 0.05 to 0.20 grams of vitamin E or tocopherol, and 10 to 17 grams of propylene glycol, and 20 to 40 grams of purified water.

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