A continuous synthesis reactor and method for non-natural amino acids

Abstract

The application relates to the field of amino acid synthesis, and specifically discloses a continuous synthesis reaction kettle for unnatural amino acids and a method, which comprises a reaction kettle body, a feeding port arranged on the reaction kettle body, a bearing assembly for placing a catalyst arranged in the reaction kettle body, a rotating assembly connected with the bearing assembly arranged in the reaction kettle body, a driving assembly connected with the rotating assembly arranged on the reaction kettle body, and a stirring assembly arranged on the rotating assembly. The application can realize the stirring effect of the reaction liquid, is beneficial to the full contact between the catalyst and the reaction liquid, is convenient for the synthesis reaction of the amino acid, can effectively supplement the catalyst, can on-line detect the catalyst, realizes the effect of accurate feeding, solves the problems of inconvenient feeding and difficult manual operation, does not need to interrupt the production process, is beneficial to continuous production, improves the production efficiency, improves the product consistency, and improves the process stability.

Description

Technical Field

[0001] This invention relates to the field of amino acid synthesis technology, and in particular to a continuous synthesis reactor and method for non-natural amino acids. Background Technology

[0002] Non-natural amino acids refer to amino acids that are not included in the 20 common protein amino acids encoded by the standard genetic code in nature. They are mainly synthesized artificially. Non-natural amino acids have a wide range of applications, such as in the fields of medicine and bioengineering. They are mainly synthesized through chemical synthesis, bio-enzyme catalysis, and microbial synthesis. In the synthesis process, reaction vessels are used to efficiently, stably, and continuously produce non-natural amino acids. However, due to the many factors to consider in reaction vessel synthesis, there are also many technical problems.

[0003] In amino acid synthesis, a catalyst needs to be added to the reaction solution to accelerate the reaction rate. However, in continuous reaction operations, the catalyst is constantly exposed to stirring or flowing scouring environments, making it susceptible to wear, breakage, or even loss due to mechanical impact. Often, the catalyst gradually diminishes over time, leading to a decrease in reaction rate, reduced product yield, and increased byproducts. Therefore, it is necessary to periodically test the catalyst quality and replenish it. However, since the catalyst is located inside the reactor, its quality is difficult to monitor in real time, and catalyst addition is inconvenient. Manual sampling, testing, or replenishment is not only difficult and time-consuming but also requires interrupting the continuous production process, which is detrimental to continuous production, reduces production efficiency, and affects product consistency. This reduces process stability. For example, in the existing patent CN103521159A, a reaction vessel for synthesizing amino acids is disclosed. The reaction vessel is ingeniously conceived and rationally designed. The stirring shaft and stirring propeller, which are eccentrically positioned inside the vessel, can effectively change the flow state of the reaction liquid inside the vessel during agitation, which is beneficial to improving mass and heat transfer efficiency. Automatic pH adjustment, temperature adjustment, and pressure adjustment realize precise automated operation of the system, making this reaction vessel particularly suitable for the synthesis of amino acids to improve the yield and quality of amino acid synthesis. This solution can achieve the stirring effect of the reaction liquid, but it still cannot achieve the problem of online detection and addition of catalyst.

[0004] Therefore, how to provide a continuous synthesis reactor and method for non-natural amino acids is a problem that urgently needs to be solved by those skilled in the art. Summary of the Invention

[0005] One objective of this invention is to provide a continuous synthesis reactor and method for non-natural amino acids. The continuous synthesis reactor for non-natural amino acids according to this invention includes a reactor body with a feeding port. A catalyst support assembly is disposed within the reactor body. A rotating assembly connected to the support assembly is disposed within the reactor body. A driving assembly connected to the rotating assembly is disposed on the reactor body. A stirring assembly is disposed on the rotating assembly. A lifting assembly is disposed on the reactor body. A detection assembly is disposed between the lifting assembly and the support assembly. A jacking assembly adapted to the detection assembly is disposed on the reactor body. A contact assembly is disposed on the lifting assembly. An adjusting assembly electrically connected to the detection assembly is disposed on the reactor body. During stirring, the detection assembly is closed, and the jacking assembly moves downward via the support assembly, controlling the stirring assembly to be in an open state. During catalyst replenishment, the detection assembly is opened, and the jacking assembly moves upward via the support assembly, controlling the stirring assembly to be in a contracted state.

[0006] Preferably, the support assembly includes a support ring disposed within the reactor body, a support mesh connected to the support ring by a bearing, a catalyst placed on the support mesh, and a support rod disposed on the support ring.

[0007] Preferably, the rotating assembly includes a rotating rod connected to the reactor body by a bearing, a locking rod is provided on the rotating rod, a fixing ring is fixedly sleeved on the rotating rod, and a sliding ring is slidably sleeved on the rotating rod in sequence. The rotating rod and the locking rod pass through the sliding ring, and the sliding ring at the tail end is connected to the support net.

[0008] Preferably, the drive assembly includes a drive motor mounted on the reactor body, the output shaft of the drive motor is connected to a drive bevel gear, and a driven bevel gear meshing with the drive bevel gear is fixedly sleeved on the rotating rod.

[0009] Preferably, the stirring assembly includes a stirring rod one hinged to the fixed ring, a stirring rod two hinged to the stirring rod one, and the remaining stirring rod one and stirring rod two are alternately hinged to the sliding ring.

[0010] Preferably, the lifting assembly includes a hydraulic lifting rod mounted on the reactor body, and the output end of the hydraulic lifting rod is provided with a mounting bracket; the contact assembly includes a support column provided on the mounting bracket, a limit plate provided on the support column, and a pressure sensing plate provided on the limit plate.

[0011] Preferably, the detection component includes an electromagnet disposed on the mounting bracket, and a magnet block adapted to the electromagnet is disposed on the support rod.

[0012] Preferably, the lifting assembly includes a hydraulic push rod mounted on the reactor body, and the output end of the hydraulic push rod is provided with a magnetically shielded top block connected to the magnet block.

[0013] Preferably, the adjustment component includes a resistance bar disposed on the reactor body, an electric push rod disposed on the reactor body, and a conductive ring adapted to the resistance bar disposed at the output end of the electric push rod, wherein the resistance bar is connected in series with the electromagnet and the conductive ring.

[0014] A method for continuous synthesis of non-natural amino acids using a reactor is also proposed. During the synthesis of non-natural amino acids, the reaction solution is placed inside the reactor body, and an appropriate amount of catalyst is added through the inlet to accelerate the reaction efficiency. During the synthesis process, the reaction solution needs to be stirred. At this time, the electromagnet is de-energized, causing the magnetic shielding block to lift the magnetic block. The hydraulic push rod is activated, causing it to move the magnetic block downwards, which in turn causes the support rod to descend, forcing the bearing assembly to open the stirring rods one and two. During stirring, the drive assembly is activated, forcing the rotating assembly to rotate, which in turn rotates the stirring rods one and two, thus achieving the stirring effect. As the reaction time progresses, the catalyst gradually decreases, therefore, it is necessary to adjust the catalyst... The catalyst is replenished to ensure the reaction proceeds normally. To precisely control the amount of catalyst, the electromagnet is energized, activating the hydraulic push rod. This causes the hydraulic push rod to move the magnet upwards until the magnet contacts the pressure sensing plate, causing the magnetic shielding block to retract. At this point, the electromagnet attracts the magnet, simultaneously causing the support rod to move upwards. This forces the bearing assembly to retract the stirring rods, causing the bearing net to move upwards. As the catalyst decreases, when the attraction between the electromagnet and the magnet remains constant, the pressure on the pressure sensing plate increases. The current to the electromagnet is adjusted using the regulating component until the pressure on the pressure sensing plate returns to its standard value. The amount of catalyst to be replenished is determined based on the change in current, achieving precise catalyst replenishment.

[0015] The beneficial effects of this invention are as follows: In the synthesis of non-natural amino acids, this invention involves placing the reaction solution into the reactor body and adding an appropriate amount of catalyst through the inlet to accelerate the reaction efficiency. During the synthesis process, the reaction solution needs to be stirred. At this time, the detection component is turned off, allowing the lifting component to contact the detection component. The lifting component is then activated, causing it to move the detection component downwards, which in turn causes the support component to descend, forcing it to open the stirring component. During stirring, the drive component is activated, forcing the rotating component to rotate, which in turn rotates the stirring component, thus agitating the reaction solution and achieving the stirring effect. As the reaction time progresses, the catalyst gradually decreases, requiring replenishment to ensure the reaction continues normally. To precisely control the amount of catalyst, the detection component is turned on, energizing it. The lifting component is then activated, causing it to move the detection component upwards until it contacts the contact component, at which point the lifting component is forced to open. During the retraction process, the detection components attract each other, causing the supporting component to move upwards. This forces the supporting component to drive the stirring component to contract, causing the supporting component to move upwards as the catalyst decreases. Because of the reduced catalyst, when the attraction between the detection components remains constant, the pressure sensed by the contact component increases. The current is adjusted using the regulating component to bring the pressure sensed by the contact component to a standard value. The amount of catalyst to be replenished is determined based on the change in current, thus achieving precise catalyst replenishment. In summary, this application's non-natural amino acid continuous synthesis reactor and method can achieve a stirring effect on the reaction liquid, facilitating full contact between the catalyst and the reaction liquid, promoting amino acid synthesis, effectively replenishing the catalyst, and enabling online catalyst detection for precise dispensing. This solves the problems of inconvenient dispensing and difficult manual operation, eliminates the need to interrupt the production process, promotes continuous production, improves production efficiency, enhances product consistency, and increases process stability. Attached Figure Description

[0016] The accompanying drawings are provided to further illustrate the invention and form part of the specification. They are used in conjunction with embodiments of the invention to explain the invention and do not constitute a limitation thereof. In the drawings: Figure 1 This is a three-dimensional structural diagram of the present invention; Figure 2 This is a schematic diagram of the internal structure of the present invention; Figure 3 For the present invention Figure 2 Side view; Figure 4 This is a structural entity diagram of the rotating assembly of the present invention; Figure 5 This is a diagram showing the connection relationship between the load-bearing component and the sliding ring of the present invention; Figure 6 This is a structural schematic diagram of the stirring assembly of the present invention; Figure 7 This is a structural schematic diagram of the lifting assembly, detection assembly, and contact assembly of the present invention; Figure 8 For the present invention Figure 7 Side view; Figure 9 This is a structural entity diagram of the lifting assembly of the present invention; Figure 10 This is a structural entity diagram of the adjustment component of the present invention.

[0017] In the diagram: 1. Reactor body; 101. Feeding port; 2. Bearing assembly; 201. Bearing ring; 202. Bearing mesh; 203. Support rod; 3. Rotating assembly; 301. Rotating rod; 302. Clamping rod; 303. Fixed ring; 304. Sliding ring; 4. Driving assembly; 401. Drive motor; 402. Driving bevel gear; 403. Driven bevel gear; 5. Stirring assembly; 501. Stirring rod one; 502. Stirring rod two; 6. Lifting assembly; 601. Hydraulic lifting rod; 602. Mounting bracket; 7. Detection assembly; 701. Electromagnet; 702. Magnetic block; 8. Lifting assembly; 801. Hydraulic push rod; 802. Magnetic shielding top block; 9. Contact assembly; 901. Support column; 902. Limiting plate; 903. Pressure sensing plate; 10. Adjusting assembly; 1001. Resistance bar; 1002. Electric push rod; 1003. Conductive ring. Detailed Implementation

[0018] The present invention will now be described in further detail with reference to the accompanying drawings. These drawings are simplified schematic diagrams, illustrating only the basic structure of the invention, and therefore only show the components relevant to the invention.

[0019] like Figure 1 , Figure 2 , Figure 3 , Figure 4 , Figure 5 , Figure 6 , Figure 7 , Figure 8 , Figure 9 and Figure 10As shown, the present invention discloses a continuous synthesis reactor for non-natural amino acids, comprising a reactor body 1, a pipeline connected to the reaction liquid for conveying the reaction liquid, a feeding port 101 for feeding a catalyst, a support assembly 2 for supporting the catalyst and preventing it from scattering, a rotating assembly 3 connected to the support assembly 2, and a driving assembly 4 connected to the rotating assembly 3 for providing power, a stirring assembly 5 for stirring the reaction liquid, and a lifting assembly 6 for lifting the reactor body 1. Component 6 is used to adjust the height of the detection component 7. The detection component 7 is located between the lifting component 6 and the supporting component 2. The detection component 7 works on the principle of electromagnetic force. The reactor body 1 is equipped with a lifting component 8 that is compatible with the detection component 7. The lifting component 8 and the detection component 7 are connected by abutment. The lifting component 6 is equipped with a contact component 9, which is used to detect the force. The reactor body 1 is equipped with an adjustment component 10 that is electrically connected to the detection component 7. The adjustment component 10 replaces manual operation and has higher precision. During stirring, the detection component 7 is closed, and the lifting component 8 moves downward through the supporting component 2 to control the stirring component 5 to be in an open state. When adding catalyst, the detection component 7 is opened, and the lifting component 8 moves upward through the supporting component 2 to control the stirring component 5 to be in a contracted state.

[0020] Working Principle: In the synthesis of non-natural amino acids, the reaction solution is placed into the reactor body 1. An appropriate amount of catalyst is added into the reactor body 1 through the inlet 101 to accelerate the reaction efficiency. During the synthesis process, the reaction solution needs to be stirred. At this time, the detection component 7 is closed, allowing the lifting component 8 to contact the detection component 7. The lifting component 8 is then activated, causing it to move the detection component 7 downwards, which in turn causes the support component 2 to descend, forcing the support component 2 to drive the stirring component 5 to open. During stirring, the drive component 4 is activated, forcing the rotating component 3 to rotate, which in turn drives the stirring component 5 to rotate. The stirring component 5 agitates the reaction solution, thus achieving a stirring effect. As the reaction time progresses, the catalyst gradually decreases, requiring replenishment to ensure the reaction proceeds normally. To precisely control the amount of catalyst, the detection component 7 is activated, energizing it. The lifting component 8 is then activated, causing it to move the detection component 7 upwards until it contacts the contact component 9. Then, the lifting component 8 is forced to retract. At this time, the detection components 7 attract each other, causing the supporting component 2 to move upward. This forces the supporting component 2 to drive the stirring component 5 to contract, causing the supporting component 2 to move upward. Due to the reduction of catalyst, when the attraction between the detection components 7 remains unchanged, the pressure sensed by the contact component 9 will increase. The current is adjusted by the regulating component 10 so that the pressure sensed by the contact component 9 reaches the standard value. The amount of catalyst to be replenished is determined based on the change in current, thereby achieving the effect of precise catalyst replenishment. In summary, the non-natural amino acid continuous synthesis reactor and method of this application can achieve the stirring effect of the reaction liquid, which is conducive to the full contact between the catalyst and the reaction liquid, facilitating the synthesis reaction of amino acids. It can effectively replenish the catalyst and can detect the catalyst online, achieving the effect of precise addition. It solves the problems of inconvenient addition and difficult manual operation, without interrupting the production process, which is conducive to continuous production, improves production efficiency, improves product consistency, and improves process stability.

[0021] Example 2: like Figure 1 , Figure 2 , Figure 3 , Figure 4 , Figure 5 , Figure 6 , Figure 7 , Figure 8 , Figure 9 and Figure 10As shown, the present invention discloses a non-natural amino acid continuous synthesis reactor. The supporting component 2 includes a supporting ring 201 disposed inside the reactor body 1. The supporting ring 201 is in contact with the inner wall of the reactor body 1. A supporting net 202 is connected to the supporting ring 201 by a bearing. The supporting net 202 prevents the catalyst from falling to the bottom of the reactor body 1 and facilitates the mass measurement of the catalyst. The catalyst is placed on the supporting net 202. A support rod 203 is provided on the supporting ring 201, which provides support and guidance.

[0022] like Figure 1 , Figure 2 , Figure 3 , Figure 4 , Figure 5 , Figure 6 , Figure 7 , Figure 8 , Figure 9 and Figure 10 As shown, the present invention discloses a non-natural amino acid continuous synthesis reactor. The rotating assembly 3 includes a rotating rod 301 connected to the reactor body 1 by a bearing. The rotating rod 301 is vertically arranged, and a locking rod 302 is provided on the rotating rod 301. The locking rod 302 is arranged along the length direction of the rotating rod 301. A fixing ring 303 is fixedly sleeved on the rotating rod 301. The fixing ring 303 is located at the upper part of the rotating rod 301. Multiple sliding rings 304 are slidably sleeved on the rotating rod 301 and are evenly distributed. The rotating rod 301 and the locking rod 302 pass through the sliding rings 304. The tail sliding ring 304 is connected to the support net 202.

[0023] like Figure 1 , Figure 2 , Figure 3 , Figure 4 , Figure 5 , Figure 6 , Figure 7 , Figure 8 , Figure 9 and Figure 10 As shown, the present invention provides a non-natural amino acid continuous synthesis reactor. The drive assembly 4 includes a drive motor 401 mounted on the reactor body 1. The drive motor 401 is a prior art technology. The output shaft of the drive motor 401 is connected to a driving bevel gear 402. A driven bevel gear 403 that meshes with the driving bevel gear 402 is fixedly sleeved on the rotating rod 301. The size of the driving bevel gear 402 and the driven bevel gear 403 is designed according to the requirements.

[0024] like Figure 1 , Figure 2 , Figure 3 , Figure 4 , Figure 5 , Figure 6 , Figure 7 , Figure 8 , Figure 9 and Figure 10 As shown, in a non-natural amino acid continuous synthesis reactor of the present invention, the stirring assembly 5 includes a stirring rod 501 hinged to a fixed ring 303, a second stirring rod 502 hinged to the first stirring rod 501, and the remaining stirring rods 501 and 502 are alternately hinged to a sliding ring 304. The first stirring rod 501 is hinged to the fixed ring 303, the remaining stirring rods 501 are hinged to the sliding ring 304, and the second stirring rods 502 are alternately hinged to the sliding ring 304. When the stirring rods 501 and 502 are open, the stirring function is realized.

[0025] like Figure 1 , Figure 2 , Figure 3 , Figure 4 , Figure 5 , Figure 6 , Figure 7 , Figure 8 , Figure 9 and Figure 10 As shown, the present invention discloses a non-natural amino acid continuous synthesis reactor. The lifting assembly 6 includes a hydraulic lifting rod 601 mounted on the reactor body 1. The hydraulic lifting rod 601 is a prior art technology. The output end of the hydraulic lifting rod 601 is provided with a mounting frame 602, which provides support. The contact assembly 9 includes a support column 901 mounted on the mounting frame 602. The support column 901 serves as a connection. A limit plate 902 is provided on the support column 901, which serves as a limit. A pressure sensing plate 903 is provided on the limit plate 902. The pressure sensing plate 903 is a prior art technology used to measure pressure.

[0026] like Figure 1 , Figure 2 , Figure 3 , Figure 4 , Figure 5 , Figure 6 , Figure 7 , Figure 8 , Figure 9 and Figure 10 As shown, the present invention provides a non-natural amino acid continuous synthesis reactor. The detection component 7 includes an electromagnet 701 mounted on a mounting frame 602 and a magnet block 702 adapted to the electromagnet 701 mounted on a support rod 203. When the electromagnet 701 is energized, it generates an attractive force to attract the magnet block 702. Conversely, when the power is off, the attractive force disappears.

[0027] like Figure 1 , Figure 2 , Figure 3 , Figure 4 , Figure 5 , Figure 6 , Figure 7 , Figure 8 , Figure 9 and Figure 10 As shown, the non-natural amino acid continuous synthesis reactor of the present invention includes a lifting assembly 8 comprising a hydraulic push rod 801 mounted on the reactor body 1. The hydraulic push rod 801 provides a lifting action, and the output end of the hydraulic push rod 801 is provided with a magnetic shielding top block 802 connected to a magnet block 702. The magnetic shielding top block 802 has a magnetic shielding effect, preventing the magnet block 702 from attracting other components.

[0028] like Figure 1 , Figure 2 , Figure 3 , Figure 4 , Figure 5 , Figure 6 , Figure 7 , Figure 8 , Figure 9 and Figure 10 As shown, the present invention discloses a non-natural amino acid continuous synthesis reactor. The regulating component 10 includes a resistance bar 1001 disposed on the reactor body 1. The resistance value of the resistance bar 1001 is adjustable. An electric push rod 1002 is disposed on the reactor body 1. The electric push rod 1002 is arranged horizontally. The output end of the electric push rod 1002 is provided with a conductive ring 1003 adapted to the resistance bar 1001. The resistance bar 1001 is connected in series with the electromagnet 701 and the conductive ring 1003.

[0029] Working principle: First, prepare by connecting the electromagnet 701, conductive ring 1003, resistance strip 1001, and corresponding current instruments in series in a circuit with a power switch. When synthesizing non-natural amino acids, place the reaction solution into the reaction vessel body 1 and add an appropriate amount of catalyst into the reaction vessel body 1 through the inlet 101. The catalyst is used to accelerate the reaction efficiency. During the synthesis process, the reaction solution needs to be stirred. At this time, turn off the power to the electromagnet 701 so that the magnetic shielding top block 802 contacts the magnet block 702. When the hydraulic push rod 801 is activated, under the influence of gravity, the hydraulic push rod 801 moves downward, causing the magnet block 702 to move downward, which in turn causes the support rod 203 to move vertically downward. The support rod 203 drives the bearing ring 201 to move downward, which in turn drives the bearing mesh 202 to move downward. The bearing mesh 202 drives the catalyst to move downward to a reasonable height position, and the bearing mesh 202 drives the sliding ring 304 at the end to move downward, forcing the stirring rod 501 and the stirring rod 502 to be in an open state. During stirring, the drive motor is activated. The output shaft of the drive motor 401 rotates, which drives the active bevel gear 402 to rotate. The active bevel gear 402 rotates, which drives the driven bevel gear 403 to rotate. The driven bevel gear 403 rotates, which drives the rotating rod 301 to rotate. The rotating rod 301 rotates, which drives the fixed ring 303 to rotate. Under the action of the clamping rod 302, the sliding ring 304, the bearing net 202, the stirring rod 1 501 and the stirring rod 2 502 are forced to rotate, so that the stirring rod 1 501 and the stirring rod 2 502 stir the reaction liquid, thereby achieving the stirring effect. As the reaction time progresses, the catalyst gradually decreases, necessitating replenishment to ensure the reaction proceeds normally. To precisely control the catalyst quantity, electromagnet 701 is activated, generating an attractive force. This activates hydraulic push rod 801, causing it to move magnet block 702 upwards until it contacts pressure sensor 903 and electromagnet 701. At this point, electromagnet 701 attracts magnet block 702. Reverse activation of hydraulic push rod 801 then moves magnetic shielding block 802 backwards. Simultaneously, magnet block 702 moves support rod 203 upwards, causing support rod 203 to move bearing ring 201 and bearing mesh 202 upwards. This forces stirring rods 501 and 502 to contract, suspending bearing mesh 202 for easy catalyst quality monitoring. Due to the catalyst reduction, the positions of limit plate 902 and pressure sensor 903 remain unchanged, and hydraulic lifting rod 601 does not move. Therefore, the height of the mounting bracket 602 remains unchanged. When the attraction between the electromagnet 701 and the magnet 702 remains unchanged, the mass of the catalyst, the support net 202, and the support rod 203 decreases. This causes the support rod 203 to move the magnet 702 closer to the electromagnet 701, increasing the contact pressure between the magnet 702 and the pressure sensing plate 903. At this time, the electric push rod 1002 is activated, causing the output end of the electric push rod 1002 to move the conductive ring 1003 on the resistor strip 1001, increasing the resistance of the resistor strip 1001. This reduces the attraction of the electromagnet 701, forcing the contact pressure between the magnet 702 and the pressure sensing plate 903 to return to the standard value. The device records the change in current and performs analysis and calculation. By using the change in current, the amount of catalyst to be added is determined, achieving the effect of precise catalyst replenishment. Then, the electric push rod 1002 is activated in reverse, causing the conductive ring 1003 to return to its original position on the resistor strip 1001, preparing for the next addition of catalyst. When adding catalyst, this device achieves uniform catalyst distribution. Activating the hydraulic lifting rod 601 moves the mounting frame 602 upwards, causing the electromagnet 701 to move away from the magnet block 702. Activating the hydraulic push rod 801 moves the magnetic shielding top block 802 to its maximum height, causing the support rod 203 to move the carrying ring 201 and carrying net 202 to their maximum height, bringing the carrying net 202 closer to the dispensing port 101. During dispensing, the drive motor 401 is activated. Under the action of the driving bevel gear 402 and the driven bevel gear 403, the rotating rod 301 rotates, causing the fixed ring 303 and sliding ring 304 to rotate, forcing the carrying net 202 to rotate uniformly, allowing the catalyst to fall evenly onto the carrying net 202. This effectively combines the device's stirring, dispensing, and online catalyst monitoring functions, achieving a multi-functional feature.

[0030] This application achieves two main benefits: firstly, it enables stirring of the reaction solution, facilitating full contact between the catalyst and the reaction solution and promoting the synthesis of amino acids; secondly, it allows for effective replenishment of the catalyst and online detection of the catalyst, achieving precise dosing and solving the problems of inconvenient dosing and difficult manual operation. It eliminates the need to interrupt the production process, promotes continuous production, improves production efficiency, enhances product consistency, and increases process stability.

[0031] Example 3: like Figure 1 , Figure 2 , Figure 3 , Figure 4 , Figure 5 , Figure 6 , Figure 7 , Figure 8 , Figure 9 and Figure 10 As shown, this invention proposes a method for continuous synthesis of non-natural amino acids using a reactor. During the synthesis of non-natural amino acids, the reaction solution is placed inside the reactor body 1, and an appropriate amount of catalyst is added inside the reactor body 1 through the inlet 101 to accelerate the reaction efficiency. During the synthesis process, the reaction solution needs to be stirred. At this time, the energization of the electromagnet 701 is turned off, causing the magnetic shielding top block 802 to lift the magnetic block 702. The hydraulic push rod 801 is activated, causing the magnetic block 702 to move downwards, resulting in the support rod 203 descending. This forces the bearing assembly 2 to open the stirring rods 501 and 502. During stirring, the drive assembly 4 is activated, forcing the rotating assembly 3 to rotate, thereby rotating the stirring rods 501 and 502, achieving the stirring effect. As the reaction time progresses, the catalyst gradually decreases, therefore, it is necessary to adjust the catalyst... To ensure the reaction proceeds normally, and to precisely control the amount of catalyst, the electromagnet 701 is energized, activating the hydraulic push rod 801. This causes the hydraulic push rod 801 to move the magnet block 702 upwards until it contacts the pressure sensing plate 903, causing the magnetic shielding top block 802 to retract. At this point, the electromagnet 701 attracts the magnet block 702, simultaneously causing the support rod 203 to move upwards. This forces the bearing assembly 2 to contract the stirring rods 501 and 502, causing the bearing mesh 202 to move upwards. As the catalyst decreases, when the attraction between the electromagnet 701 and the magnet block 702 remains constant, the pressure on the pressure sensing plate 903 increases. The current of the electromagnet 701 is adjusted using the adjusting assembly 10 until the pressure on the pressure sensing plate 903 returns to its standard value. The amount of catalyst to be replenished is determined based on the change in current, thus achieving precise catalyst replenishment.

[0032] The above description is only a preferred embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any equivalent substitutions or modifications made by those skilled in the art within the scope of the technology disclosed in the present invention, based on the technical solution and inventive concept of the present invention, should be covered within the scope of protection of the present invention.

Claims

1. A continuous synthesis reactor for non-natural amino acids, characterized in that, The reactor includes a reactor body (1), which has a feeding port (101). A catalyst support assembly (2) is located inside the reactor body (1). A rotating assembly (3) connected to the support assembly (2) is located inside the reactor body (1). A drive assembly (4) connected to the rotating assembly (3) is located on the reactor body (1). A stirring assembly (5) is located on the rotating assembly (3). A lifting assembly (6) is located on the reactor body (1). A detection assembly (7) is located between the lifting assembly (6) and the support assembly (2). The body (1) is provided with a lifting component (8) adapted to the detection component (7), the lifting component (6) is provided with a contact component (9), and the reactor body (1) is provided with an adjustment component (10) electrically connected to the detection component (7); wherein, during stirring, the detection component (7) is closed, and the lifting component (8) moves downward through the bearing component (2) to control the stirring component (5) to be in an open state; during catalyst replenishment, the detection component (7) is opened, and the lifting component (8) moves upward through the bearing component (2) to control the stirring component (5) to be in a contracted state.

2. The continuous synthesis reactor for non-natural amino acids according to claim 1, characterized in that, The support assembly (2) includes a support ring (201) disposed in the reactor body (1), a support net (202) is connected to the support ring (201) by a bearing, a catalyst is placed on the support net (202), and a support rod (203) is disposed on the support ring (201).

3. The continuous synthesis reactor for non-natural amino acids according to claim 2, characterized in that, The rotating assembly (3) includes a rotating rod (301) connected to the reactor body (1) by a bearing. A locking rod (302) is provided on the rotating rod (301). A fixing ring (303) is fixedly sleeved on the rotating rod (301). A sliding ring (304) is slidably sleeved on the rotating rod (301). The rotating rod (301) and the locking rod (302) pass through the sliding ring (304). The tail of the sliding ring (304) is connected to the support net (202).

4. The continuous synthesis reactor for non-natural amino acids according to claim 3, characterized in that, The drive assembly (4) includes a drive motor (401) mounted on the reactor body (1), the output shaft of the drive motor (401) is connected to a drive bevel gear (402), and a driven bevel gear (403) that meshes with the drive bevel gear (402) is fixedly sleeved on the rotating rod (301).

5. The continuous synthesis reactor for non-natural amino acids according to claim 4, characterized in that, The stirring assembly (5) includes a stirring rod one (501) hinged to the fixed ring (303), a stirring rod two (502) hinged to the stirring rod one (501), and the remaining stirring rod one (501) and stirring rod two (502) are alternately hinged to the sliding ring (304).

6. The continuous synthesis reactor for non-natural amino acids according to claim 5, characterized in that, The lifting assembly (6) includes a hydraulic lifting rod (601) installed on the reactor body (1), and the output end of the hydraulic lifting rod (601) is provided with a mounting bracket (602); the contact assembly (9) includes a support column (901) provided on the mounting bracket (602), a limit plate (902) provided on the support column (901), and a pressure sensing plate (903) provided on the limit plate (902).

7. The continuous synthesis reactor for non-natural amino acids according to claim 6, characterized in that, The detection component (7) includes an electromagnet (701) mounted on the mounting bracket (602), and a magnet block (702) adapted to the electromagnet (701) is mounted on the support rod (203).

8. The continuous synthesis reactor for non-natural amino acids according to claim 7, characterized in that, The lifting assembly (8) includes a hydraulic push rod (801) mounted on the reactor body (1), and the output end of the hydraulic push rod (801) is provided with a magnetic shielding top block (802) connected to the magnet block (702).

9. The continuous synthesis reactor for non-natural amino acids according to claim 8, characterized in that, The adjustment component (10) includes a resistance bar (1001) disposed on the reactor body (1), an electric push rod (1002) disposed on the reactor body (1), and a conductive ring (1003) adapted to the resistance bar (1001) disposed at the output end of the electric push rod (1002). The resistance bar (1001) is connected in series with the electromagnet (701) and the conductive ring (1003).

10. The method for continuous synthesis of non-natural amino acids in a reactor according to claim 9, characterized in that, When synthesizing non-natural amino acids, the reaction solution is placed in the reaction vessel body (1), and an appropriate amount of catalyst is added to the reaction vessel body (1) through the inlet (101) to accelerate the reaction efficiency. During the synthesis process, the reaction solution needs to be stirred. At this time, the power supply of the electromagnet (701) is turned off, so that the magnetic shielding top block (802) lifts the magnet block (702), and the hydraulic push rod (801) is activated, so that the hydraulic push rod (801) drives the magnet block (702) to move down, so that the support rod (203) moves down, forcing the bearing component (2) to drive the stirring rod one (501) and the stirring rod two (502) to open. During stirring, the driving component (4) is activated, forcing the rotating component (3) to rotate and drive the stirring rod one (501) and the stirring rod two (502) to rotate, thereby achieving the stirring effect. As the reaction time goes by, the catalyst will gradually decrease, so it is necessary to replenish the catalyst to ensure that the reaction proceeds normally. In order to accurately control The amount of catalyst is adjusted, the electromagnet (701) is energized, and the hydraulic push rod (801) is activated, causing the hydraulic push rod (801) to move the magnet block (702) upward until the magnet block (702) contacts the pressure sensing plate (903), causing the magnetic shielding top block (802) to retract. At this time, the electromagnet (701) attracts the magnet block (702), and at the same time, the support rod (203) moves upward, forcing the bearing assembly (2) to drive the stirring rod. (501) and the second stirring rod (502) contract, causing the supporting net (202) to move upward. Due to the reduction of catalyst, when the attraction between the electromagnet (701) and the magnet block (702) remains unchanged, the pressure of the pressure sensing plate (903) will increase. Using the adjustment component (10), the current of the electromagnet (701) is adjusted until the pressure of the pressure sensing plate (903) returns to the standard value. The amount of catalyst to be replenished is determined according to the change of current, thus achieving the effect of precise catalyst replenishment.

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