Lactobacillus plantarum XKFY202518 and application thereof in preparation of 2-type diabetes auxiliary preparation for improving insulin resistance and regulating blood lipid

By preparing Lactobacillus plantarum XKFY202518 bacterial agent, combined with prebiotics and fillers, the problem of adverse effects of existing drugs on the body was solved, and insulin resistance and dyslipidemia in type 2 diabetic mice were improved.

CN122104489APending Publication Date: 2026-05-29CHONGQING UNIV OF EDUCATION
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
CHONGQING UNIV OF EDUCATION
Filing Date
2026-01-14
Publication Date
2026-05-29

AI Technical Summary

Technical Problem

Existing medications for treating type 2 diabetes have many adverse effects on the body, necessitating the development of highly effective and safe probiotic preparations to improve insulin resistance and regulate blood lipids.

Method used

A bacterial agent was prepared using Lactobacillus plantarum XKFY202518, and combined with prebiotics, fillers and excipients. Through cultivation, centrifugation and freeze-drying, it was prepared into an adjunct preparation for improving insulin resistance and regulating blood lipids in type 2 diabetes.

Benefits of technology

It effectively reduces fasting blood glucose, insulin, total cholesterol, triglycerides and low-density lipoprotein cholesterol levels in diabetic mice, while increasing high-density lipoprotein cholesterol levels, reducing pancreatic and liver tissue damage, and improving symptoms of hyperglycemia and hyperlipidemia.

✦ Generated by Eureka AI based on patent content.

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Abstract

The present application relates to the technical field of biotechnology, and discloses a plant Lactobacillus plantarum XKFY202518 and application of the plant Lactobacillus plantarum XKFY202518 in preparation of a type 2 diabetes auxiliary preparation for improving insulin resistance and regulating blood lipid, the plant Lactobacillus plantarum XKFY202518 has a preservation number of CGMCC No.34745 in China General Microbiological Culture Collection Center, and a preservation date of June 3, 2025.The plant Lactobacillus plantarum XKFY202518 separated by the present application can effectively reduce the fasting blood glucose level, insulin level, total cholesterol level, triglyceride level, low-density lipoprotein cholesterol level, alanine aminotransferase level and aspartate aminotransferase level of a diabetic mouse, and increase the high-density lipoprotein cholesterol level of the mouse serum, thereby improving the hyperglycemia and hyperlipidemia symptoms of a type 2 diabetes mouse.
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