Cosmetic agents containing adenosine

Abstract

This invention relates to a sprayable hair care product in the form of an oil-in-water emulsion, having a pH value of 3.0 to 7.0 at 20°C, comprising at least one water-insoluble oil component (A), at least one nonionic emulsifier (B), at least one nonionic co-emulsifier (C), water, and a buffer system for stabilizing the pH value, wherein the water content is equal to 60 to 90% by weight, component (A) is provided in an amount of 1.5 to 20% by weight, and components (B) and (C) are provided in a total amount of 1 to 12% by weight. The invention is characterized in that adenosine is provided in an amount of 0.01 to 3% by weight, and urea and / or urea derivatives are provided in a total amount of 1.0 to 25% by weight. This invention also relates to a method for preparing a sprayable aqueous formulation of adenosine, wherein an aqueous solution of adenosine is mixed with a finely dispersed emulsion of an oil component (A) such that the formulation contains 1.5 to 20% by weight of the emulsified oil component (A), wherein the average droplet diameter of the oil component (A) (measured using a device based on the principle of quasi-elastic light scattering (Zetasizer Nano ZS, 25°C, square polystyrene cuvette, 12 mm side length (model DTS0012), dilution: 0.025% w / w in water)) is less than 1 μm. During or after preparation and before mixing with the adenosine solution, the emulsion is brought to a phase transition temperature, and urea and / or urea derivatives are added to the resulting mixture at room temperature. This invention also relates to the use of a sprayable aqueous formulation containing adenosine and urea and / or urea derivatives with an ethanol content of less than 18% by weight for cosmetic treatment of the skin, particularly the scalp.

Description

[0001] This invention relates to the field of hair care products (Haartonika). It comprises a sprayable, water-based agent containing adenosine, which has skin and hair care effects.

[0002] This invention relates to hair care agents with hair conditioning effects (e.g., preventing hair loss and promoting hair growth). Adenosine is an active ingredient used in various cosmetic formulations (e.g., hair care agents) to prevent hair loss and promote hair growth. Such agents are preferably sprayed onto the scalp and hair for easy application and should be able to be applied without making the hair heavy.

[0003] It is desirable to be able to use high concentrations of adenosine in these reagents to achieve satisfactory results for users. Currently, high concentrations of adenosine (0.1% to 1.5% by weight) are only available in sprayable reagents with an ethanol content of at least 20% by weight. Adenosine cannot be stably incorporated into sprayable reagents with significantly lower ethanol contents. However, reagents with such high ethanol content cause severe scalp dryness in consumers and lead to faster fading of dyed hair. Therefore, it is desirable to provide reagents that overcome these drawbacks.

[0004] Therefore, the object of the present invention is to provide a stable sprayable water-containing reagent in which adenosine is present in a high concentration and the reagent does not dry out the scalp.

[0005] Surprisingly, this goal can be achieved using an oil-in-water emulsion containing adenosine.

[0006] Therefore, the first subject of this application is a sprayable hair care product in the form of an oil-in-water emulsion, having a pH value of 3.0 to 7.0 at 20°C, comprising at least one water-insoluble oil component (A), at least one nonionic emulsifier (B), at least one nonionic co-emulsifier (C), water, and a buffer system for stabilizing the pH value, wherein... Water content equal to 60 to 90% by weight Component (A) is provided in an amount of 1.5 to 20% by weight, and Components (B) and (C) are provided in total amounts of 1 to 12% by weight. The invention is characterized in that adenosine is provided in an amount of 0.01 to 3% by weight, and urea and / or urea derivatives are provided in a total amount of 1.0 to 25% by weight.

[0007] The reagent according to the invention comprises 1.5 to 20% by weight, preferably 3.5 to 15% by weight, and particularly preferably 5 to 10% by weight of a water-insoluble oil component (A). The water-insoluble oil component (A) is preferably selected from: fatty acid esters with an alkyl chain length of C8 to C36, natural or synthetic triglycerides, hydrocarbons that are liquid at 20°C and 1013 mbar, and mixtures thereof.

[0008] Fatty acid esters with an alkyl chain length of C8 to C36 are preferably those esterified with saturated alcohols with an alkyl chain length of C3 to C26. Preferably, for example, they are saturated C8 to C36 fatty acid esters. 12-18 Caprylic (C8OOH) ester / decanoic acid (C8OOH) ester of fatty alcohols 10 OOH) esters and / or isopropyl myristate. Based on the reagent according to the invention, these fatty acid esters are preferably used in amounts of 5 to 20% by weight, particularly preferably 7 to 15% by weight.

[0009] Natural triglycerides can be vegetable triglycerides, such as olive oil, almond oil, peanut oil, sunflower oil, soybean oil, rapeseed oil, palm oil, or the liquid portion of coconut oil or palm kernel oil, or mixtures thereof. Natural triglycerides can also be animal-derived triglycerides, such as the liquid portion of cow's hoof oil and / or tallow. When using natural triglycerides, it is preferred according to the invention that they are vegetable triglycerides. Synthetic triglycerides can be those obtained by esterification of glycerol with fatty acids having 8 to 22 carbon atoms, such as triglycerides of caprylic-capric acid mixtures, triglycerides from industrial oleic acid or from palmitic-oleic acid mixtures, or mixtures thereof.

[0010] Natural or synthetic triglycerides, fatty acid esters, or mixtures thereof are preferably those that are liquid at 20°C and 1013 mbar. However, triglycerides with higher melting points and esters conforming to the given formulas may also be used in amounts that keep the mixture of oil components liquid at 20°C and 1013 mbar. Based on the reagent according to the invention, these triglycerides are preferably used in amounts of 1.5 to 20% by weight, particularly preferably 3.5 to 15% by weight.

[0011] The hydrocarbons that are liquid at 20°C and 1013 mbar can be C11 to C16 hydrocarbons, such as linear or branched C11 to C16 hydrocarbons. Preferably, for example, they are mixtures of n-undecane and n-tetane or isododecane and / or isohexadecane. Based on the reagent according to the invention, these hydrocarbons are preferably used in amounts of 5 to 20% by weight, particularly preferably 7 to 15% by weight.

[0012] Therefore, the preferred subject is the reagent listed above, wherein the water-soluble oil component (A) is selected from fatty acid esters with an alkyl chain length of C8 to C36, natural or synthetic triglycerides, hydrocarbons that are liquid at 20°C and 1013 mbar, and mixtures thereof.

[0013] A further preferred subject is the reagent listed above, wherein the water-soluble oil component (A) is saturated C 12-18 Caprylic (C8OOH) ester / decanoic acid (C8OOH) ester of fatty alcohols 10The mixture of triglycerides of OOH ester and octanoic acid-decanoic acid mixture is preferably 2.0 to 10 by weight.

[0014] The reagent according to the invention comprises at least one nonionic emulsifier (B) and at least one nonionic co-emulsifier (C) in a total amount of 1 to 12% by weight. The total amount of the nonionic emulsifier (B) and the nonionic co-emulsifier (C) in the reagent according to the invention is preferably 3.0 to 10% by weight, particularly preferably 5.0 to 8.0% by weight.

[0015] At least one nonionic emulsifier (B) may preferably be one or more representatives from the group consisting of alkoxylated C8-C22 fatty alcohols, more preferably alkoxylated C16-C22 fatty alcohols. Particularly preferred are ethoxylated C8-C22 fatty alcohols having 8 to 26 EOs, and especially preferred are ethoxylated C16-C18 fatty alcohols having 12 to 20 EOs.

[0016] At least one nonionic emulsifier (B) may also preferably be one or more alkyl polyglucosides. In this case, it is preferably a C8 to C18 polyglucoside, particularly lauryl glucoside, decyl glucoside, and cocoyl glucoside, or a mixture thereof.

[0017] Preferably, at least one nonionic emulsifier (B) has an HLB value of 10 to 18.

[0018] Therefore, the preferred subject is the reagent listed above, wherein at least one nonionic emulsifier (B) comprises one or more representatives of the group of alkoxy C16-C22 fatty alcohols.

[0019] Therefore, another preferred subject is the reagent listed above, wherein at least one nonionic emulsifier (B) comprises one or more alkyl polyglucosides.

[0020] Therefore, another preferred subject is the reagents listed above, wherein at least one nonionic emulsifier (B) has an HLB value of 10 to 18.

[0021] Therefore, another preferred subject is the reagent listed above, wherein at least one nonionic emulsifier (B) comprises a mixture of alkoxylated C8-C22 fatty alcohols and / or C8-C16 polyglucosides.

[0022] Furthermore, a mixture (B) containing different nonionic emulsifiers is also preferred.

[0023] Another preferred subject is the reagent as described above, wherein the nonionic emulsifier (B) comprises a mixture of polyethylene glycol ether of cetearyl alcohol (20EO) and polyethylene glycol ether of cetearyl alcohol (12EO).

[0024] At least one nonionic auxiliary emulsifier (C) may preferably be one or more representatives from the group consisting of: C8-C22 monofatty acid esters of glycerol, C10-C18 monofatty acid esters of sorbitol, C12-C22 fatty alcohols, and mixtures thereof.

[0025] At least one nonionic auxiliary emulsifier (C) may preferably be a C8-C22 monofatty acid ester of glycerol or a mixture thereof, particularly preferably glyceryl monostearate, glyceryl monolaurate, glyceryl caprylate, or a mixture thereof.

[0026] At least one nonionic auxiliary emulsifier (C) may preferably be a sorbitol C10-C18 monofatty acid ester or a mixture thereof, particularly preferably sorbitol monolaurate, sorbitol monooleate, sorbitol monostearate, or a mixture thereof.

[0027] At least one nonionic auxiliary emulsifier (C) may preferably be a C12-C22 fatty alcohol, particularly preferably cetearyl alcohol, myristyl alcohol, betaine alcohol, or a mixture thereof.

[0028] Therefore, the preferred subject matter is the reagent listed above, wherein at least one nonionic auxiliary emulsifier (C) comprises one or more representatives from the group consisting of: C8-C22 monofatty acid esters of glycerol, C10-C18 monofatty acid esters of sorbitol, C12-C22 fatty alcohols, and mixtures thereof.

[0029] Therefore, a further preferred subject is the reagent listed above, wherein at least one nonionic auxiliary emulsifier (C) comprises a C12-C22 monofatty acid ester of glycerol, or a mixture thereof, particularly preferably glyceryl monostearate.

[0030] Therefore, another preferred subject is the reagent listed above, wherein at least one nonionic auxiliary emulsifier (C) comprises a C10-C18 monofatty acid ester of sorbitol, or a mixture thereof, particularly preferably sorbitol monolaurate, sorbitol monooleate, sorbitol monostearate, or a mixture thereof.

[0031] Therefore, another preferred subject is the reagent listed above, wherein at least one nonionic auxiliary emulsifier (C) has C12-C22 fatty alcohols, or mixtures thereof, with cetearyl alcohol being particularly preferred.

[0032] Furthermore, mixtures (C) with different nonionic auxiliary emulsifiers are also preferred.

[0033] Therefore, a further preferred subject is the reagent listed above, wherein the nonionic co-emulsifier (C) is a mixture of mono-fatty acid esters of glycerol (mainly stearic acid (C18) and palmitic acid (C16) (INCI: glyceryl monostearate)) and cetearyl alcohol.

[0034] Therefore, the further preferred materials are the reagents listed above, wherein The nonionic emulsifier (B) is a mixture of polyethylene glycol ether of cetearyl alcohol (20EO) and polyethylene glycol ether of cetearyl alcohol (12EO). The nonionic auxiliary emulsifier (C) is a mixture of mono-fatty acid esters of glycerol (mainly stearic acid (C18) and palmitic acid (C16) (INCI: glyceryl monostearate)) and cetearyl alcohol, and the total amount of components (B) and (C) is preferably 3.0 to 10% by weight, particularly preferably 5.0 to 8.0% by weight.

[0035] Therefore, another preferred subject is the reagent as listed above, wherein The nonionic emulsifier (B) is a mixture of polyethylene glycol ether of cetearyl alcohol (20EO) and polyethylene glycol ether of cetearyl alcohol (12EO). The nonionic co-emulsifier (C) comprises a mixture of mono-fatty acid esters of glycerol (primarily stearic acid (C18) and palmitic acid (C16) (INCI: glyceryl monostearate)) and cetearyl alcohol, and The water-soluble oil component (A) is saturated C 12-18 Caprylic (C8OOH) ester / decanoic acid (C8OOH) ester of fatty alcohols 10 A mixture of triglycerides of OOH) esters and a mixture of caprylic-capric acid, or saturated C 12-18 Caprylic (C8OOH) ester / decanoic acid (C8OOH) ester of fatty alcohols 10 OOH) ester, or a mixture of n-undecane and n-tetrazane, or isopropyl myristate.

[0036] Urea derivatives can be used in combination with urea or as a substitute for urea, thereby maintaining the total amount at 1.0 to 25% by weight. According to the invention, it is preferred that the total amount of urea and / or urea derivatives is equal to 1.0 to 15% by weight, preferably 2.0 to 8.0% by weight, more preferably 3.0 to 6.0% by weight. If a urea derivative is used, it is preferably 2-hydroxyethylurea. In these cases, 2-hydroxyethylurea is preferably used in an amount of 1.0 to 15% by weight, particularly preferably 2.0 to 7.0% by weight, especially 2.0 to 5.0% by weight. 2-hydroxyethylurea is preferably used in combination with urea. In these cases, the preferred amount of urea is equal to 0.05 to 3.0% by weight, more preferably 0.1 to 1.0% by weight, especially 0.1 to 0.5% by weight, and the preferred amount of 2-hydroxyethylurea is equal to 1.0 to 15% by weight, more preferably 1.5 to 7% by weight, especially 2.0 to 5.0% by weight. In such combinations, the ratio of 2-hydroxyethylurea to urea is particularly preferably 20:1 to 10:1.

[0037] Therefore, the preferred subject is the aforementioned hair growth agent, wherein the urea derivative is 2-hydroxyethylurea.

[0038] Another preferred subject is the aforementioned hair growth agent, wherein the total amount of urea and / or urea derivatives is equal to 1.0 to 15% by weight, preferably 2.0 to 8.0% by weight, more preferably 3.0 to 6.0% by weight.

[0039] The claimed hair growth agent contains 0.01 to 3.0% by weight of adenosine. Adenosine is a nucleotide composed of the nucleobase adenine and the sugar β-D-ribose. Preferred reagents contain 0.05 to 3.0% by weight, particularly preferably 0.1 to 2% by weight, and especially preferably 0.1 to 1.0% by weight of adenosine. Furthermore, reagents containing 0.2 to 1.5% by weight, especially 0.5 to 1.0% by weight of adenosine, may be preferred.

[0040] Therefore, the preferred subject is a hair growth agent containing 0.1 to 2.0% by weight, particularly 0.1 to 1.0% by weight, of adenosine.

[0041] The claimed hair growth agent contains adenosine as an active ingredient. The hair growth agent may also contain adenosine derivatives, such as adenosine 5'-phosphate. Preferably, the claimed reagent contains only a limited amount of adenosine derivatives, such as adenosine-5'-phosphate, for example, adenosine monophosphate (INCI: adenosine monophosphate), adenosine diphosphate, and / or adenosine triphosphate (INCI: adenosine triphosphate). Preferably, the reagent contains less than 0.5% by weight, particularly preferably less than 0.2% by weight, and especially less than 0.1% by weight of adenosine monophosphate. In particular, it may be preferred that the reagent is free of adenosine monophosphate. In this context, "free of adenosine monophosphate" means that adenosine monophosphate is neither added as a separate ingredient nor introduced into the claimed reagent through formulations of other ingredients, for example, in an amount not exceeding 0.001% by weight based on the total mass of the reagent.

[0042] Therefore, the preferred subject is a hair growth agent containing less than 0.5% by weight, particularly less than 0.2% by weight, and especially less than 0.1% by weight of one or more ingredients from the group consisting of adenosine 5'-phosphate.

[0043] Therefore, the preferred subject is a hair growth agent containing 0.05 to 3.0% by weight, particularly 0.1 to 2% by weight, and especially 0.1 to 1.0% by weight of adenosine.

[0044] Therefore, a further preferred subject is the reagents listed above, wherein The nonionic emulsifier (B) is a mixture of polyethylene glycol ether of cetearyl alcohol (20EO) and polyethylene glycol ether of cetearyl alcohol (12EO). The nonionic co-emulsifier (C) is a mixture of mono-fatty acid esters of glycerol (primarily stearic acid (C18) and palmitic acid (C16) (INCI: glyceryl monostearate)) and cetearyl alcohol, and The water-soluble oil component (A) is saturated C 12-18 Caprylic (C8OOH) ester / decanoic acid (C8OOH) ester of fatty alcohols 10 A mixture of triglycerides of OOH) esters and a mixture of caprylic-capric acid, or saturated C 12-18 Caprylic (C8OOH) ester / decanoic acid (C8OOH) ester of fatty alcohols 10 OOH) ester, or a mixture of n-undecane and n-tridecane, or isopropyl myristate, and Adenosine is provided in amounts of 0.05 to 3.0% by weight, particularly preferably 0.1 to 2% by weight, and especially 0.5 to 1.0% by weight.

[0045] Therefore, a further preferred subject is the reagents listed above, wherein The nonionic emulsifier (B) is a mixture of polyethylene glycol ether of cetearyl alcohol (20EO) and polyethylene glycol ether of cetearyl alcohol (12EO). The nonionic co-emulsifier (C) is a mixture of mono-fatty acid esters of glycerol (primarily stearic acid (C18) and palmitic acid (C16) (INCI: glyceryl monostearate)) and cetearyl alcohol, and The water-soluble oil component (A) is saturated C 12-18 Caprylic (C8OOH) ester / decanoic acid (C8OOH) ester of fatty alcohols 10 A mixture of triglycerides of OOH) esters and a mixture of caprylic-capric acid, or saturated C 12-18 Caprylic (C8OOH) ester / decanoic acid (C8OOH) ester of fatty alcohols 10 OOH) ester, or a mixture of n-undecane and n-tridecane, or isopropyl myristate, and Adenosine is provided in an amount of 0.05 to 3.0% by weight, particularly preferably 0.1 to 2% by weight, especially 0.5 to 1.0% by weight, and has less than 0.5% by weight, particularly preferably less than 0.2% by weight, especially less than 0.1% by weight, of one or more components from the group of adenosine 5'-phosphates.

[0046] The aqueous formulation contains 50 to 90% by weight of water. A formulation containing 70 to 80% by weight of water is preferred. The water is primarily used to adjust the concentration of the previously defined ingredients to a range suitable for an aqueous spray hair conditioner.

[0047] The claimed compositions are stabilized by a buffer system. In particular, this allows for storage at elevated temperatures (e.g., 40°C). The buffer substance and its concentration are preferably selected to ensure the stability of the contained active ingredient in the aqueous composition. Stabilization can also occur at elevated temperatures (e.g., 40°C); all pH values ​​described herein are applicable to measurements at 20°C. Any type of buffer system suitable for cosmetic reagents can be used, which stabilizes the desired pH range and maintains the pH in the range of 3.0 to 7.0, preferably 4.0 to 6.0, and particularly 4.2 to 5.5. This is preferably a lactate / lactate buffer, such as one containing sodium lactate, or a citrate / disodium hydrogen phosphate buffer.

[0048] If a lactate / sodium lactate buffer solution is used, different concentrations are possible. Preferably, based on the total composition, the concentration of lactate is equal to 0.5 to 3.5% by weight, and the concentration of sodium lactate is equal to 1.5 to 20% by weight. In particular, it is preferred that the ratio of lactate to sodium lactate within this range is 0.02 to 2.3.

[0049] For some subjects, based on the total composition, the concentration of lactic acid is preferably 0.5 to 2% by weight, and the concentration of sodium lactate is 1.5 to 2.5% by weight. In particular, it is preferred that the ratio of lactic acid to sodium lactate within this range is 0.3 to 0.8. For other subjects, based on the total composition, the concentration of lactic acid is preferably 2 to 3% by weight, particularly preferably 2.2 to 2.6% by weight, and the concentration of sodium lactate is 13 to 20% by weight, particularly preferably 15.5 to 17.0% by weight. In particular, it is preferred that the ratio of lactic acid to sodium lactate within this range is 0.1 to 0.2.

[0050] If a citrate / disodium hydrogen phosphate buffer solution is used, the concentration of citrate monohydrate is preferably 0.5 to 1.5% by weight, and the concentration of disodium hydrogen phosphate dihydrate is preferably 0.8 to 2.5% by weight, based on the total composition. If citrate and / or disodium hydrogen phosphate are used in anhydrous form, the concentrations must be reduced accordingly.

[0051] In particular, it is preferred that the ratio of citric acid monohydrate to disodium hydrogen phosphate dihydrate is 0.2 to 2.0 within this range.

[0052] Therefore, it is preferred that the claimed hair care product contains a lactate / sodium lactate buffer solution, which stabilizes the pH of the product and maintains the pH in the range of 3.0 to 7.0, preferably 4.0 to 6.0, and particularly 4.2 to 5.5.

[0053] For other claimed reagents, it is also preferred that the hair growth agent contains a citrate / disodium hydrogen phosphate buffer solution, which stabilizes the pH of the reagent and maintains the pH in the range of 3.0 to 7.0, preferably 4.0 to 6.0, and particularly 4.2 to 5.5.

[0054] Therefore, the preferred subject is the reagent listed above, wherein the buffer system is lactate / sodium lactate buffer or citrate / disodium hydrogen phosphate buffer.

[0055] Preferably, the aforementioned amounts of buffering material are used in all of the aforementioned compounds and subsequent compositions, thereby enabling them to achieve the stated purpose.

[0056] To ensure improved skin compatibility compared to compositions with high ethanol content, the hair care product claimed to contain less than 18% by weight, particularly preferably no more than 10% by weight, and especially preferably no more than 5% by weight of ethanol.

[0057] Therefore, the preferred subject is a hair care agent as described above, which contains less than 18% by weight, particularly preferably no more than 10% by weight, and especially preferably no more than 5% by weight of ethanol.

[0058] Furthermore, it is preferred that the hair care product for which protection is claimed contains no more than 5% by weight, particularly preferably less than 1% by weight, especially preferably less than 0.5% by weight of ethanol, or contains no ethanol.

[0059] In this context, "ethanol-free" means that ethanol is neither added as a separate ingredient nor introduced into the claimed reagent through formulations of other ingredients, for example, the amount added or introduced based on the total mass of the reagent is no more than 2% by weight. Therefore, another preferred subject matter is a hair growth agent as described above, which contains no more than 5% by weight, particularly preferably less than 1% by weight, especially preferably less than 0.5% by weight, and even more preferably less than 0.1% by weight of ethanol, or is ethanol-free.

[0060] The claimed hair care product may contain one or more excipients. These optional excipients can further stabilize hair care products with very low ethanol content and those without ethanol. Therefore, a preferred subject is a hair care product containing at least one excipient from the group consisting of glycols, glycol ethers, and glycerin, or mixtures thereof. A preferred subject is also a hair care product as described above, containing no more than 5% by weight, particularly preferably less than 1% by weight, especially preferably less than 0.5% by weight, and even more preferably less than 0.1% by weight of ethanol and at least one excipient from the group consisting of glycols, glycol ethers, and glycerin, or mixtures thereof.

[0061] Hair care products according to the invention that optionally contain such excipients preferably contain 1 to 20% by weight, preferably no more than 15% by weight, and particularly no more than 10% by weight of these excipients.

[0062] Therefore, the preferred subject matter is a hair care product that also contains at least one diol as an optional excipient. The diol may preferably be ethylene glycol, 1,2-propanediol, 1,3-propanediol, 1,2-butanediol, 1,2-pentanediol, or dipropylene glycol, or mixtures thereof.

[0063] If at least one diol is used as an excipient, such diol or a mixture of several diols is preferably included in the claimed reagent in a total amount of 0.5 to 15% by weight. The diol is particularly preferred to be 1,2-propanediol and / or 1,2-pentanediol. If 1,2-propanediol is used as an excipient, it is preferably provided in the claimed reagent in an amount of 2 to 20% by weight, particularly preferably 3 to 15% by weight. If 1,2-pentanediol is used as an excipient, it is preferably provided in the claimed reagent in an amount of 0.5 to 5% by weight, particularly preferably 1 to 3.5% by weight.

[0064] Therefore, another preferred subject matter is a claimed hair growth agent that also comprises at least one glycol ether as an optional excipient. The glycol ether may preferably be one or more compounds from the group consisting of monomethyl ether, monoethyl ether, and monopropyl ether and mixtures thereof. If a glycol ether is used as an optional excipient, it is preferably provided in the claimed agent in a total amount of 0.5 to 15% by weight. The optional glycol ether is particularly preferably diethylene glycol monoethyl ether. If used, it is provided in the claimed agent in an amount of 0.5 to 15% by weight, particularly preferably 5.0 to 10% by weight.

[0065] Therefore, another preferred subject is a hair care agent that also contains glycerin as an optional excipient. If glycerin is used as an optional excipient, it is preferably provided in the claimed agent in an amount of 0.5 to 15% by weight, particularly preferably in an amount of 5.0 to 10% by weight.

[0066] To ensure the stability of the composition and to achieve a fine distribution of the components, it is important that the oil component (A) exists as small droplets in the emulsion. According to the invention, it is preferred that the average droplet diameter of the oil component (A), measured using a device based on the principle of quasi-elastic light scattering (Zetasizer Nano ZS, 25 °C, square polystyrene cuvette, 12 mm side length (model DTS0012), dilution: 0.025% w / w in water), is less than 1 μm, preferably less than 600 nm, and more preferably less than 300 nm.

[0067] Therefore, the preferred subject is a hair growth agent as described above, wherein the average droplet diameter of the oil component (A), as measured by an apparatus based on the principle of quasi-elastic light scattering (Zetasizer Nano ZS, 25°C, square polystyrene cuvette, 12mm side length (model DTS0012), dilution: 0.025% w / w in water), is less than 1 μm, preferably less than 600 nm, and more preferably less than 300 nm.

[0068] The claimed water-based sprayable hair conditioner can be easily applied to the relevant area by the user because it is sprayable and therefore can be distributed finely and evenly. To ensure good sprayability, the hair treatment composition according to the invention preferably does not contain viscosity-increasing ingredients (such as polyquaternium polymers known as INCI names polyquaternium-10 and polyquaternium-37), provided that this is economical to operate (i.e., provided that small amounts of the corresponding substances are not introduced as trace components or impurities as industrial standard ingredients). Based on the total weight of the hair treatment composition, such viscosity-increasing ingredients and similar ingredients are preferably provided in the hair treatment agent according to the invention in an amount of no more than 2% by weight, more preferably no more than 0.5% by weight, and particularly preferably no more than 0.1% by weight.

[0069] According to the present invention, the claimed hair growth agent preferably has a viscosity of not more than 150 mPa*s, particularly preferably 0.8 to 50 mPa*s, and especially 1.0 to 20.0 mPa*s, as measured by a Brookfield rotational viscometer (DV1 type, rotor 1, 20 RPM) to ensure good sprayability.

[0070] Therefore, the preferred subject is the hair care agent for which protection is claimed as described above, having a viscosity of not more than 150 mPa*s, particularly preferably 0.8 to 50 mPa*s, and especially 1.0 to 20.0 mPa*s, as measured by a Brookfield rotational viscometer (DV1 type, rotor 1, 20 RPM).

[0071] Compositions capable of achieving the above objectives are prepared in a specific manner. Therefore, another subject of this application is a method for preparing a sprayable aqueous formulation of adenosine, wherein an aqueous solution of adenosine is mixed with a finely dispersed emulsion of an oil component (A) such that the formulation contains 1.5 to 20% by weight of an emulsified oil component (A), the oil component (A) having an average droplet diameter less than 1 μm (measured using a device based on the principle of quasi-elastic light scattering (Zetasizer Nano ZS, 25°C, square polystyrene cuvette, 12 mm side length (model DTS0012), dilution: 0.025% w / w in water); wherein, during or after preparation and before mixing with the adenosine solution, the emulsion is brought to a phase transition temperature, and urea and / or urea derivatives are added to the resulting mixture at room temperature.

[0072] In the preferred method, the average droplet diameter of the oil component (A) is preferably less than 600 nm, more preferably less than 300 nm.

[0073] Furthermore, a preferred method is one in which the aqueous solution of adenosine has a temperature not exceeding 50°C, preferably not exceeding 45°C, and / or the temperature of the finely dispersed emulsion of oil component (A) is 30 to 50°C, preferably 30 to 40°C, all of which are measured directly before the solution and the emulsion are mixed.

[0074] Furthermore, a preferred method is one in which urea and / or urea derivatives are added in solid form.

[0075] A particularly preferred method is one in which the finely dispersed emulsion of the oil component (A) is a PIT emulsion, the PIT emulsion further comprising at least one nonionic emulsifier (B) and at least one nonionic co-emulsifier (C).

[0076] Furthermore, the method according to the invention is preferred, wherein after adding urea and / or urea derivatives, the pH of the formulation is adjusted to a value of 3.0 to 7.0, and this pH is stabilized by adding a buffer system.

[0077] Therefore, the preferred subject matter is the claimed method as described above, wherein the temperature of the aqueous solution of adenosine is not higher than 50°C, preferably not higher than 45°C, and / or the temperature of the finely dispersed emulsion of oil component (A) is 30 to 50°C, preferably 30 to 40°C, all of which are measured directly before the solution and the emulsion are mixed.

[0078] Therefore, another preferred subject is the claimed method as described above, wherein urea and / or urea derivatives are added in solid form.

[0079] Therefore, another preferred subject matter is the claimed method as described above, wherein the finely dispersed emulsion of the oil component (A) is a PIT emulsion, the PIT emulsion further comprising at least one nonionic emulsifier (B) and at least one nonionic auxiliary emulsifier (C).

[0080] Therefore, another preferred subject matter is the claimed method as described above, wherein after the addition of urea and / or urea derivatives, the pH of the formulation is adjusted to a value of 3.0 to 7.0, and this pH is stabilized by adding a buffer system.

[0081] Therefore, a particularly preferred subject matter is the claimed method as described above, wherein the finely dispersed emulsion of the oil component (A) is a PIT emulsion, the PIT emulsion further comprising at least one nonionic emulsifier (B) and at least one nonionic co-emulsifier (C), and wherein, after the addition of urea and / or urea derivatives, the pH of the formulation is adjusted to a value of 3.0 to 7.0 and this pH value is stabilized by adding a buffer system, wherein, if applicable, the temperature of the aqueous solution of adenosine is not higher than 50°C, preferably not higher than 45°C, and / or the temperature of the finely dispersed emulsion of the oil component (A) is 30 to 50°C, preferably 30 to 40°C, all of which are measured directly before the solution is mixed with the emulsion, and wherein, if applicable, the urea and / or urea derivatives are added in solid form.

[0082] The above have illustrated stable aqueous compositions containing high concentrations of adenosine. Therefore, another subject of this application is the use of urea and / or urea derivatives for stabilizing adenosine in aqueous emulsions with an ethanol content of less than 18% by weight. Therefore, a further subject of this application is the use of urea and / or urea derivatives, along with optionally present excipients, for stabilizing adenosine in aqueous emulsions with an ethanol content of less than 18% by weight, wherein said excipients are selected from glycols, polyethylene glycols, glycol ethers, glycerol, polyglycerol derivatives, amine oxides, betaine, amino alcohols, and lactates, or mixtures thereof.

[0083] Therefore, a further subject of this application is the use of a sprayable aqueous emulsion containing adenosine and urea and / or urea derivatives with an ethanol content of less than 18% by weight for cosmetic treatment of the skin, particularly the scalp. Therefore, a further subject of this application is the use of a sprayable aqueous emulsion containing adenosine, urea and / or urea derivatives, and optionally excipients, with an ethanol content of less than 18% by weight, for cosmetic treatment of the skin, particularly the scalp, wherein said excipients are selected from glycols, polyethylene glycols, glycol ethers, glycerin, polyglycerol derivatives, amine oxides, betaine, amino alcohols, and lactates, or mixtures thereof.

[0084] Another subject of this application is the use of a sprayable aqueous formulation containing adenosine and urea and / or urea derivatives with an ethanol content of less than 18% by weight for cosmetic treatment of the skin, particularly the scalp.

[0085] All information provided for the reagents also applies directly to the methods and uses described herein. This applies in particular, but not exclusively, to the data and characteristics of components (A), (B), and (C), buffer substances and systems, excipients, ethanol content, viscosity, pH value, measurement methods, and other specified components.

[0086] The subject matter for which protection is claimed is further described, but not exhaustively, by the following entries: Item 1: A sprayable hair care product in the form of an oil-in-water emulsion, having a pH value of 3.0 to 7.0 at 20°C, comprising at least one water-insoluble oil component (A), at least one nonionic emulsifier (B), at least one nonionic co-emulsifier (C), water, and a buffer system for stabilizing said pH value, wherein... Water content equal to 60 to 90% by weight Component (A) is provided in an amount of 1.5 to 20% by weight, and Components (B) and (C) are provided in total amounts of 1 to 12% by weight. The invention is characterized in that adenosine is provided in an amount of 0.01 to 3% by weight, and urea and / or urea derivatives are provided in a total amount of 1.0 to 25% by weight.

[0087] Item 2: The reagent according to Item 1, wherein the reagent comprises less than 0.5% by weight, particularly preferably less than 0.2% by weight, especially less than 0.1% by weight, of one or more components from the group of adenosine 5'-phosphates.

[0088] Item 3: The reagent according to one of the preceding items, wherein the buffer system is a lactate / sodium lactate buffer or a citrate / disodium hydrogen phosphate buffer.

[0089] Item 4: The reagent according to one of the above items, wherein the urea derivative is 2-hydroxyethylurea.

[0090] Item 5: The reagent according to any one of the preceding items, wherein the total amount of urea and / or urea derivatives is 1.0 to 15% by weight, preferably 2.0 to 8.0% by weight, more preferably 3.0 to 6.0% by weight.

[0091] Item 6: A reagent according to any one of the preceding items, wherein the reagent comprises at least one excipient from the group consisting of glycols, glycol ethers, and glycerol.

[0092] Item 7: The reagent according to Item 6, wherein the excipient is selected from 1,2-propanediol or 1,2-pentanediol, or a mixture thereof.

[0093] Item 8: The reagent according to Item 6 or Item 7, wherein the excipient is provided in a total amount of 1 to 20% by weight, preferably not more than 15% by weight, and particularly not more than 10% by weight.

[0094] Item 9: According to the reagent of one of the preceding items, the average droplet diameter of the oil component (A), as measured by an apparatus based on the principle of quasi-elastic light scattering (Zetasizer Nano ZS, 25°C, square polystyrene cuvette, side length 12 mm (model DTS0012), dilution: 0.025% w / w in water), is less than 1 μm, preferably less than 600 nm, more preferably less than 300 nm.

[0095] Item 10: A formulation according to any one of the preceding items, wherein the viscosity of said reagent, measured at 20°C using a Brookfield rotational viscometer (DV1 type, rotor 1, 20 RPM), is not higher than 150 mPa*s, particularly preferably 0.8 to 50 mPa*s, and especially 1 to 20 mPa*s.

[0096] Item 11: The reagent according to any one of the preceding items, wherein the at least one water-soluble oil component (A) is selected from fatty acid esters with an alkyl chain length of C8 to C36, natural or synthetic triglycerides, hydrocarbons that are liquid at 20°C and 1013 mbar, and mixtures thereof.

[0097] Item 12: The reagent according to one of the preceding items, wherein the at least one nonionic emulsifier (B) is one or more representatives from the group consisting of alkoxylated C8-C22 fatty alcohols, preferably alkoxylated C16-C22 fatty alcohols.

[0098] Item 13: The reagent according to one of the preceding items, wherein the at least one nonionic emulsifier (B) is one or more representatives from the group consisting of alkyl polyglucosides.

[0099] Item 14: The reagent according to one of the preceding items, wherein the at least one nonionic emulsifier (B) has an HLB value of 10 to 18.

[0100] Item 15: The reagent according to any one of the preceding items, wherein the at least one nonionic auxiliary emulsifier (C) is one or more representatives from the group consisting of: C8-C22 monofatty acid esters of glycerol, C10-C18 monofatty acid esters of sorbitol, C12-C22 fatty alcohols, and mixtures thereof.

[0101] Item 16: A reagent according to any one of the preceding items, wherein the reagent contains less than 18% by weight, preferably not more than 10% by weight, particularly preferably not more than 5% by weight, and more preferably less than 1% by weight of ethanol.

[0102] Item 15: A reagent according to any one of the preceding items, wherein the reagent comprises 0.05 to 3.0% by weight, particularly preferably 0.1 to 2% by weight, especially 0.1 to 1.0% by weight of adenosine.

[0103] Item 16: A method for preparing a sprayable aqueous formulation of adenosine, wherein an aqueous solution of adenosine is mixed with a finely dispersed emulsion of an oil component (A) such that the formulation contains 1.5 to 20% by weight of an emulsified oil component (A), the oil component (A) having an average droplet diameter of less than 1 μm (measured using a device based on the principle of quasi-elastic light scattering (Zetasizer Nano ZS, 25°C, square polystyrene cuvette, 12 mm side length (model DTS0012), dilution: 0.025% w / w in water); wherein, during or after preparation and before mixing with the adenosine solution, the emulsion is brought to a phase transition temperature, and urea and / or urea derivatives are added to the resulting mixture at room temperature.

[0104] Item 17: Sprayable aqueous formulations containing adenosine and urea and / or urea derivatives with an ethanol content of less than 18% by weight for cosmetic treatment of the skin, particularly the scalp.

[0105] Exemplary implementation scheme: For preparation, an (auxiliary) emulsifier is converted into a PIT emulsion along with the oil component and water, wherein the emulsion is brought to a phase transition temperature during or after its preparation. The emulsion is then mixed at 30 to 35°C with an aqueous adenosine solution (1.5% to 2.5%) containing a buffer, excipients, and a pH adjuster at approximately 50°C. After cooling to room temperature (20°C), a fragrance (optionally present) is added first, followed by the addition of urea in solid form, stirred into the cooled PIT emulsion.

[0106] The following compositions are provided:

[0107] 1 INCI: Glyceryl stearate (and) cetearyl alcohol polyether-20 (and) cetearyl alcohol polyether-12 (and) cetearyl alcohol (and) cetyl palmitate 2 INCI: Cetearyl alcohol polyether-12 3 INCI: Cocoyl octanoate / decanoate It has been shown that PIT emulsions containing urea or urea and excipients can stabilize adenosine to obtain a sprayable composition with a suitable viscosity. If such a composition also contains a suitable buffering medium, adenosine can be stabilized for extended periods (E1 to E4) even at elevated temperatures.

Claims

1. A sprayable hair care product in the form of an oil-in-water emulsion, having a pH value of 3.0 to 7.0 at 20°C, comprising at least one water-insoluble oil component (A), at least one nonionic emulsifier (B), at least one nonionic co-emulsifier (C), water, and a buffer system for stabilizing said pH value, wherein: Water content equal to 60 to 90% by weight Component (A) is provided in an amount of 1.5 to 20% by weight, and Components (B) and (C) are provided in total amounts of 1 to 12% by weight. The invention is characterized in that adenosine is provided in an amount of 0.01 to 3% by weight, and urea and / or urea derivatives are provided in a total amount of 1.0 to 25% by weight.

2. The reagent according to any one of the preceding claims, wherein the urea derivative is 2-hydroxyethylurea.

3. The reagent according to any one of the preceding claims, wherein the reagent comprises at least one excipient selected from glycols, glycol ethers, and glycerol, and the excipient is preferably provided in a total amount of 1 to 20% by weight, particularly preferably no more than 15% by weight, and especially no more than 10% by weight.

4. The reagent according to any one of the preceding claims, wherein the at least one water-soluble oil component (A) is selected from fatty acid esters with an alkyl chain length of C8 to C36, natural or synthetic triglycerides, hydrocarbons that are liquid at 20°C and 1013 mbar, and mixtures thereof.

5. The reagent according to any one of the preceding claims, wherein the at least one nonionic emulsifier (B) is selected from one or more representatives of: alkoxylated C8-C22 fatty alcohols, preferably alkoxylated C16-C22 fatty alcohols.

6. The reagent according to any one of the preceding claims, wherein the at least one nonionic auxiliary emulsifier (C) is selected from one or more representatives of: C8-C22 monofatty acid esters of glycerol, C10-C18 monofatty acid esters of sorbitol, C12-C22 fatty alcohols, and mixtures thereof.

7. The reagent according to any one of the preceding claims, wherein the reagent comprises less than 18% by weight, preferably not more than 10% by weight, particularly preferably not more than 5% by weight, and more preferably less than 1% by weight of ethanol.

8. The reagent according to any one of the preceding claims, wherein the reagent comprises 0.05 to 3.0% by weight, particularly preferably 0.1 to 2% by weight, especially 0.1 to 1.0% by weight of adenosine.

9. A method for preparing a sprayable aqueous formulation of adenosine, wherein an aqueous solution of adenosine is mixed with a finely dispersed emulsion of an oil component (A) such that the formulation contains 1.5 to 20% by weight of an emulsified oil component (A), the oil component (A) having an average droplet diameter of less than 1 μm (measured using a device based on the principle of quasi-elastic light scattering (Zetasizer Nano ZS, 25°C, square polystyrene cuvette, 12 mm side length (model DTS0012), dilution: 0.025% w / w in water); wherein, during or after preparation and before mixing with the adenosine solution, the emulsion is brought to a phase transition temperature, and urea and / or urea derivatives are added to the resulting mixture at room temperature.

10. Sprayable aqueous formulations containing adenosine and urea and / or urea derivatives with an ethanol content of less than 18% by weight for cosmetic treatment of the skin, especially the scalp.

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