Cosmetic containing adenosine

Abstract

The present application relates to aqueous sprayable hair supplements comprising urea and / or urea derivatives in a total amount of 1.0 to 20 wt.-%, and adenosine in an amount of 0.05 to 3 wt.-%, wherein the hair supplements comprise less than 18 wt.-%, preferably at most 10 wt.-%, in particular at most 5 wt.-%, of ethanol; and the use of a sprayable aqueous formulation containing adenosine and urea and / or urea derivatives with an ethanol content of less than 18 wt.-% for cosmetic treatment of the skin, in particular the scalp.

Description

[0001] This invention relates to the field of hair conditioners (Haartonika). It comprises a sprayable, aqueous product containing adenosine and possessing skin and hair conditioning properties.

[0002] This invention relates to hair supplements with hair conditioning effects (such as preventing hair loss and promoting hair growth). Adenosine is an active ingredient used in various cosmetic formulations (such as hair supplements to prevent hair loss and promote hair growth). Such products are preferably sprayed onto the scalp and hair for easy application and should be applicable without making the hair heavy.

[0003] The goal is to use high concentrations of adenosine in these products to achieve satisfactory results for users. Currently, high concentrations of adenosine (0.1% to 1.5% by weight) are only available in sprayable products with an ethanol content of at least 20% by weight. Adenosine cannot be stably incorporated into sprayable products with lower ethanol contents. However, products with such high ethanol content cause severe dryness of the scalp and faster fading of colored hair. Therefore, it is desirable to provide products that overcome these drawbacks.

[0004] Therefore, the object of the present invention is to provide a stable, sprayable, aqueous product in which adenosine is present in a high concentration and which does not dry out the scalp.

[0005] Surprisingly, it was discovered that this objective can be achieved through a composition comprising urea or urea derivatives and adenosine.

[0006] Therefore, the first subject of this application is an aqueous sprayable hair supplement comprising 1.0 to 20% by weight of urea and / or urea derivatives, 0.05 to 3% by weight of adenosine, and a buffer system for stabilizing pH, characterized in that the hair supplement comprises less than 18% by weight, preferably up to 10% by weight, and particularly up to 5% by weight of ethanol.

[0007] Urea derivatives can be used in combination with urea or in place of urea to maintain a total amount of 1.0 to 20% by weight. If a urea derivative is used, 2-hydroxyethyl urea is preferred. In these cases, the amount of 2-hydroxyethyl urea is preferably 1.0 to 15% by weight, particularly preferably 2.0 to 7.0% by weight, and especially 2.0 to 5.0% by weight. Preferably, 2-hydroxyethyl urea is used in combination with urea. In these cases, the preferred amount of urea is 0.05 to 3.0% by weight, particularly preferably 0.1 to 1.0% by weight, and especially 0.1 to 0.5% by weight, and the preferred amount of 2-hydroxyethyl urea is 1.0 to 15% by weight, particularly preferably 1.5 to 7% by weight, and especially 2.0 to 5.0% by weight. In such combinations, the ratio of 2-hydroxyethyl urea to urea is particularly preferably 20:1 to 10:1.

[0008] Therefore, the preferred subject is the aforementioned hair supplement, wherein the urea derivative is 2-hydroxyethylurea.

[0009] A further preferred subject is the aforementioned hair supplement, wherein the total amount of urea and / or urea derivatives is 1.0 to 15% by weight, preferably 2.0 to 7.0% by weight, and more preferably 2.0 to 5.0% by weight.

[0010] The claimed hair supplement contains 0.05 to 3% by weight of adenosine. Adenosine is a nucleotide and consists of the nucleic acid base adenine and the sugar β-D-ribose. Preferred products contain 0.1 to 2% by weight, particularly 0.1 to 1% by weight of adenosine. Furthermore, products containing 0.2 to 1.5% by weight, particularly 0.5 to 1.0% by weight of adenosine, are also preferred.

[0011] Therefore, hair supplements containing 0.1 to 2% by weight, particularly 0.1 to 1% by weight, of adenosine are preferred.

[0012] The claimed hair supplement contains adenosine as an active ingredient. The hair supplement may also contain adenosine derivatives, such as 5'-adenosine monophosphate (INCI), adenosine diphosphate (ADP), and / or adenosine triphosphate (INCI). Preferably, the claimed product contains only a limited amount of adenosine derivatives, such as 5'-adenosine monophosphate (ADP), for example, ADP, and / or ADP triphosphate (INCI). Preferably, the product contains less than 0.5% by weight, particularly preferably less than 0.2% by weight, and especially less than 0.1% by weight of adenosine monophosphate. In particular, it may be preferred that the product is free of adenosine monophosphate. In this context, "free of adenosine monophosphate" means that adenosine monophosphate is neither added as a separate ingredient nor introduced into the claimed product through formulations of other ingredients, for example, in an amount of at most 0.001% by weight based on the total mass of the product.

[0013] The claimed hair tonic contains less than 18% by weight, preferably up to 10% by weight, and particularly up to 5% by weight of ethanol. A preferred subject is a hair tonic containing 5.0 to 10.0% by weight of ethanol as described above. Another preferred subject is a hair tonic as described above, containing up to 5% by weight, particularly preferably less than 1% by weight, especially preferably less than 0.5% by weight of ethanol, or ethanol-free. In this context, "ethanol-free" means that ethanol is neither added as a separate ingredient nor introduced into the claimed product through formulation of other ingredients, for example, in an amount of up to 2% by weight based on the total mass of the product.

[0014] Therefore, the preferred subject is a water-based sprayable hair supplement comprising: 1.0 to 20% by weight of urea and / or urea derivatives; 0.05 to 3% by weight of adenosine; and 5.0 to 10% by weight of ethanol.

[0015] Therefore, a further preferred subject is a water-based sprayable hair supplement comprising: 1.0 to 15 or 20% by weight, preferably 2.0 to 7.0% by weight, particularly 2.0 to 5.0% by weight, of urea and / or 2-hydroxyethylurea; 0.05 to 3% by weight, preferably 0.1 to 2% by weight, particularly preferably 0.2 to 1.5% by weight, particularly 0.5 to 1.0% by weight, of adenosine; and 5.0 to 10% by weight, of ethanol.

[0016] The claimed water-based sprayable hair conditioner can be easily applied by the user to the relevant area because it is sprayable and thus can be finely and evenly distributed. To ensure good sprayability, the hair treatment composition according to the invention preferably does not contain viscosity-increasing ingredients (such as polyquaternium polymers known as INCI names polyquaternium-10 and polyquaternium-37), provided that this is economical to operate (i.e., provided that small amounts of the corresponding substances are not introduced as trace components or impurities as industry standard ingredients). Based on the total weight of the hair treatment composition, such viscosity-increasing ingredients and similar ingredients are preferably included in the hair treatment agent according to the invention in an amount of up to 2% by weight, more preferably up to 0.5% by weight, and particularly preferably up to 0.1% by weight.

[0017] According to the present invention, the viscosity of the claimed hair supplement, as measured by a Brookfield rotational viscometer (DV1 type, rotor 1, 20 RPM), is preferably at most 150 mPa*s, particularly preferably 0.8 to 50 mPa*s, and especially 1.0 to 20.0 mPa*s, to ensure good sprayability.

[0018] Therefore, the preferred subject is the hair supplement claimed as described above, the viscosity of which, as measured by a Brookfield rotational viscometer (DV1 type, rotor 1, 20 RPM), is at most 150 mPa*s, particularly preferably 0.8 to 50 mPa*s, and especially 1.0 to 20.0 mPa*s.

[0019] The aqueous implementation contains a certain amount of water. Preferably, the implementation contains 50 to 99% by weight, particularly preferably 65 to 95% by weight, and especially particularly 70 to 90% by weight of water. The water is primarily used to adjust the concentration of the previously defined ingredients to a range suitable for an aqueous sprayable hair conditioner.

[0020] The claimed hair tonic may contain one or more excipients. These optionally present excipients can further stabilize the hair tonic with a very low ethanol content. Therefore, preferred subject matter is a hair tonic containing at least one excipient from: glycol, polyethylene glycol, glycol ether, glycerin, polyglycerol derivatives, amine oxide, betaine, amino alcohol and lactate, or mixtures thereof. Preferred subject matter is also a hair tonic as described above, wherein the hair tonic contains at most 5% by weight, particularly preferably less than 1% by weight, especially preferably less than 0.5% by weight of ethanol and at least one excipient from: glycol, polyethylene glycol, glycol ether, glycerin, polyglycerol derivatives, amine oxide, betaine, amino alcohol and lactate, or mixtures thereof.

[0021] Hair supplements containing such excipients preferably contain 0.5 to 35% by weight, preferably up to 25% by weight, and particularly up to 15% by weight of these excipients.

[0022] Therefore, the preferred subject is a water-based sprayable hair conditioner comprising: 1.0 to 20% by weight of urea and / or urea derivatives; 0.05 to 3% by weight of adenosine; less than 18% by weight, preferably up to 5% by weight, particularly preferably less than 1% by weight, and especially preferably less than 0.5% by weight of ethanol; and at least one excipient selected from glycols, polyethylene glycols, glycol ethers, glycerol, polyglycerol derivatives, amine oxides, betaine, amino alcohols and lactates, or mixtures thereof, preferably in an amount of 0.5 to 25% by weight, particularly preferably up to 15% by weight, and especially up to 10% by weight.

[0023] Therefore, the preferred subject matter is the claimed hair supplement that also contains at least one diol as an optional excipient. The diol may preferably be ethylene glycol, 1,2-propanediol, 1,3-propanediol, 1,2-butanediol, 1,2-pentanediol, or dipropylene glycol, or mixtures thereof. If at least one diol is used as an excipient, the diol or mixture of diols is preferably included in the claimed product in a total amount of 0.5 to 20% by weight. The diol is particularly preferred to be 1,2-propanediol and / or 1,2-pentanediol. If 1,2-propanediol is used as an excipient, it is preferably included in the claimed product in an amount of 2 to 20% by weight, particularly preferably 3 to 15% by weight. If 1,2-pentanediol is used as an excipient, it is preferably included in the claimed product in an amount of 0.5 to 5% by weight, particularly preferably 1 to 3.5% by weight.

[0024] Therefore, the preferred subject is a water-based sprayable hair supplement comprising: 1.0 to 20% by weight of urea and / or urea derivatives; 0.05 to 3% by weight of adenosine; up to 5% by weight, preferably less than 1% by weight, particularly preferably less than 0.5% by weight of ethanol; and preferably 2 to 20% by weight, particularly preferably 3 to 15% by weight of 1,2-propanediol.

[0025] Therefore, a further preferred subject is a water-based sprayable hair supplement comprising: 1.0 to 15 or 20% by weight, preferably 2.0 to 7.0% by weight, particularly 2.0 to 5.0% by weight, of urea and / or 2-hydroxyethylurea; 0.05 to 3% by weight, preferably 0.1 to 2% by weight, particularly preferably 0.2 to 1.5% by weight, particularly 0.5 to 1.0% by weight, of adenosine; up to 5% by weight, preferably less than 1% by weight, particularly preferably less than 0.5% by weight, of ethanol; and preferably 2 to 20% by weight, particularly preferably 3 to 15% by weight, of 1,2-propanediol.

[0026] A particularly preferred subject is a water-based sprayable hair supplement comprising: 2.0 to 7.0% by weight, particularly 2.0 to 5.0% by weight, of urea and optionally 2-hydroxyethylurea; 0.2 to 1.5% by weight, particularly 0.5 to 1.0% by weight, of adenosine; less than 0.5% by weight of ethanol; and preferably 3 to 15% by weight of 1,2-propanediol.

[0027] Therefore, the preferred subject is also a water-based sprayable hair supplement comprising: 1.0 to 20% by weight of urea and / or urea derivatives; 0.05 to 3% by weight of adenosine; up to 5% by weight, preferably less than 1% by weight, particularly preferably less than 0.5% by weight of ethanol; and preferably 0.5 to 5% by weight, particularly preferably 1 to 3.5% by weight of 1,2-pentanediol.

[0028] Therefore, a further preferred subject is a water-based sprayable hair supplement comprising: 1.0 to 15 or 20% by weight, preferably 2.0 to 7.0% by weight, particularly 2.0 to 5.0% by weight, of urea and / or 2-hydroxyethylurea; 0.05 to 3% by weight, preferably 0.1 to 2% by weight, particularly preferably 0.2 to 1.5% by weight, particularly 0.5 to 1.0% by weight, of adenosine; up to 5% by weight, preferably less than 1% by weight, particularly preferably less than 0.5% by weight, of ethanol; and preferably 0.5 to 5% by weight, particularly preferably 1 to 3.5% by weight, of 1,2-pentanediol.

[0029] A particularly preferred subject is a water-based sprayable hair supplement comprising: 2.0 to 10.0% by weight, particularly 2.0 to 5.0% by weight, of urea and optionally 2-hydroxyethylurea; 0.2 to 1.5% by weight, particularly 0.5 to 1.0% by weight, of adenosine; less than 0.5% by weight of ethanol; and preferably 1 to 3.5% by weight of 1,2-pentanediol.

[0030] Therefore, a further preferred subject is a hair replacement product that also includes at least one polyethylene glycol as an optional excipient. The polyethylene glycol may preferably be derived from the formula HO-[CH2CH2O]. x One or more compounds of -H, wherein x is an integer from 2 to 100, preferably from 2 to 80, more preferably from 2 to 60, and even more preferably from 3 to 40 or from 4 to 20. If polyethylene glycol is used as an optional excipient, the polyethylene glycol or a mixture of polyethylene glycols is preferably included in the claimed product in a total amount of 0.5 to 15% by weight. The polyethylene glycol to be used is particularly preferred to be a polyethylene glycol in which x is an integer from 3 to 40. If this is used, it is preferably included in the claimed product in an amount of 0.5 to 15% by weight, particularly preferably in an amount of 5.0 to 10% by weight.

[0031] A mixture of the optional excipients described above may also be used as an optional excipient. If optional excipients are used, a further preferred approach is to use a combination of 1,2-propanediol and PEG-40 (i.e., polyethylene glycol according to the formula given above (where x = 40) (INCI: PEG-40 hydrogenated castor oil)). It is then particularly preferred that the amount of 1,2-propanediol is 1.0 to 15% by weight, and the amount of PEG-40 is 0.3 to 5.0% by weight.

[0032] Therefore, a further preferred subject is the claimed hair conditioner that also comprises at least one glycol ether as an optional excipient. The glycol ether may preferably be one or more compounds derived from monomethyl ether, monoethyl ether, and monopropyl ether, and mixtures thereof. If the glycol ether is used as an optional excipient, it is preferably included in the claimed product in a total amount of 0.5 to 15% by weight. The optional glycol ether is particularly preferably diethylene glycol monoethyl ether. If this is used, it is preferably included in the claimed product in an amount of 0.5 to 15% by weight, particularly preferably 5.0 to 10% by weight.

[0033] Therefore, a further preferred subject is the claimed hair supplement that also contains glycerin as an optional excipient. If glycerin is used as an optional excipient, it is preferably included in the claimed product in an amount of 0.5 to 15% by weight, particularly preferably in an amount of 3.0 to 10% by weight.

[0034] Therefore, a further preferred subject is the claimed hair supplement that also comprises at least one polyglycerol derivative as an optional excipient. The polyglycerol derivative may be at least one of the following: polyglycerol-6 octanoate, polyglycerol-4 decanoate, polyglycerol-3 cocoate, polyglycerol-6 ricinoleate, or polyglycerol-3 decanoate / octanoate / succinate, or mixtures thereof, as known by INCI names. If at least one polyglycerol derivative is used as an optional excipient, it is preferably included in the claimed product in a total amount of 0.3 to 15% by weight, particularly preferably 2 to 10% by weight, and especially 5 to 9% by weight. The optional polyglycerol derivative is particularly preferably a mixture of polyglycerol-6 octanoate and polyglycerol-4 decanoate. If this mixture is used, it is preferably included in the claimed product in a total amount of 0.1 to 15% by weight, particularly preferably 0.3 to 10% by weight, and especially 0.5 to 9% by weight.

[0035] Therefore, the preferred subject is also a water-based sprayable hair conditioner comprising: 1.0 to 20% by weight of urea and / or urea derivatives; 0.05 to 3% by weight of adenosine; up to 5% by weight, preferably less than 1% by weight, particularly preferably less than 0.5% by weight of ethanol; and a mixture of polyglycerol-6 octanoate and polyglycerol-4 decanoate, preferably 1 to 15% by weight, particularly preferably 2 to 10% by weight, especially 5 to 9% by weight.

[0036] Therefore, a further preferred subject is an aqueous sprayable hair supplement comprising: 1.0 to 15 or 20% by weight, preferably 2.0 to 7.0% by weight, particularly 2.0 to 5.0% by weight, of urea and / or 2-hydroxyethyl urea; 0.05 to 3% by weight, preferably 0.1 to 2% by weight, particularly preferably 0.2 to 1.5% by weight, particularly 0.5 to 1.0% by weight, of adenosine; up to 5% by weight, preferably less than 1% by weight, particularly preferably less than 0.5% by weight, of ethanol; and a mixture of polyglycerol-6 octanoate and polyglycerol-4 decanoate, preferably 1 to 15% by weight, particularly preferably 2 to 10% by weight, particularly 5 to 9% by weight.

[0037] A particularly preferred subject is a water-based sprayable hair conditioner comprising: 2.0 to 7.0% by weight, particularly 2.0 to 5.0% by weight, of urea and optionally 2-hydroxyethylurea; 0.2 to 1.5% by weight, particularly 0.5 to 1.0% by weight, of adenosine; less than 0.5% by weight of ethanol; and preferably 5 to 9% by weight of a mixture of polyglycerol-6 octanoate and polyglycerol-4 decanoate.

[0038] Alternatively, a mixture of the optional excipients described above may be used as an optional excipient. If an optional excipient is used, a combination of 1,2-propanediol and polyglycerol-6-octanoate is a further preferred option. It is particularly preferred that the amount of 1,2-propanediol is 2.0 to 20% by weight, and the amount of polyglycerol-6-octanoate is 0.3 to 9% by weight.

[0039] Therefore, a further preferred subject is the claimed hair supplement that also contains at least one amine oxide as an optional excipient. The amine oxide can be at least one selected from (C5-C18 alkyl)dimethylamine oxide or mixtures thereof. The C5-C18 alkyl chain can, for example, be an alkyl chain based on different fatty acids or fatty alcohols (such as myristic acid, cetyl alcohol, hexanoic acid, caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid, heptadecanic acid, stearic acid, linoleic acid, oleic acid, or mixtures thereof). If the amine oxide is used as an optional excipient, it is preferably included in the claimed product in a total amount of 0.2 to 5% by weight. The optional amine oxide is particularly preferably dodecyl dimethylamine oxide (INCI: laurylamine oxide), cocoyl amine oxide, or mixtures thereof. If dodecyl dimethylamine oxide is used, it is preferably included in the claimed product in a total amount of 0.2 to 10% by weight, particularly preferably 0.5 to 5% by weight, and especially 0.5 to 2% by weight.

[0040] Therefore, the preferred subject is also a water-based sprayable hair conditioner comprising: 1.0 to 20% by weight of urea and / or urea derivatives; 0.05 to 3% by weight of adenosine; up to 5% by weight, preferably less than 1% by weight, particularly preferably less than 0.5% by weight of ethanol; and preferably 0.2 to 10% by weight, particularly preferably 0.5 to 5% by weight, especially 0.5 to 2% by weight of dodecyl dimethylamine oxide.

[0041] Therefore, a further preferred subject is an aqueous sprayable hair supplement comprising: 1.0 to 15 or 20% by weight, preferably 2.0 to 7.0% by weight, particularly 2.0 to 5.0% by weight, of urea and / or 2-hydroxyethylurea; 0.05 to 3% by weight, preferably 0.1 to 2% by weight, particularly preferably 0.2 to 1.5% by weight, particularly 0.5 to 1.0% by weight, of adenosine; up to 5% by weight, preferably less than 1% by weight, particularly preferably less than 0.5% by weight, of ethanol; and preferably 0.2 to 10% by weight, particularly preferably 0.5 to 5% by weight, particularly 0.5 to 2% by weight, of dodecyl dimethylamine oxide.

[0042] A particularly preferred subject is a water-based sprayable hair conditioner comprising: 2.0 to 7.0% by weight, particularly 2.0 to 5.0% by weight, of urea and optionally 2-hydroxyethylurea; 0.2 to 1.5% by weight, particularly 0.5 to 1.0% by weight, of adenosine; less than 0.5% by weight of ethanol; and preferably 0.5 to 2% by weight of dodecyl dimethylamine oxide.

[0043] Therefore, a further preferred subject is a hair supplement containing at least one betaine as an optional excipient, which is also intended to protect the hair. Betaine may preferably be derived from the formula R-CO-NH-(CH2)3-N + (CH3)2-CH2COO - One or more compounds, wherein R represents a C5 to C21 alkyl chain. If betaine is used as an optional excipient, the betaine or a mixture of betaines is preferably included in the claimed product in a total amount of 0.1 to 5% by weight. The optional betaine is particularly preferably cocamidopropyl betaine (INCI: cocamidopropyl betaine), which is a mixture of lauroamide propyl betaine (INCI: lauroamide propyl betaine) (where R represents a saturated and unbranched C11 alkyl chain) and other betaines derived from coconut oil fatty acids having C8 to C18 alkyl chains. If cocamidopropyl betaine is used, it is preferably included in the claimed product in a total amount of 0.1 to 5% by weight, particularly preferably 0.3 to 3% by weight, and especially 0.5 to 2% by weight.

[0044] Therefore, the preferred subject is also an aqueous sprayable hair supplement comprising: 1.0 to 20% by weight of urea and / or urea derivatives; 0.05 to 3% by weight of adenosine; up to 5% by weight, preferably less than 1% by weight, particularly preferably less than 0.5% by weight of ethanol; and preferably 0.1 to 5% by weight, particularly preferably 0.3 to 3% by weight, especially 0.5 to 2% by weight of cocamidopropyl betaine.

[0045] Therefore, a further preferred subject is an aqueous sprayable hair supplement comprising: 1.0 to 15 or 20% by weight, preferably 2.0 to 7.0% by weight, particularly 2.0 to 5.0% by weight of urea and / or 2-hydroxyethylurea; 0.05 to 3% by weight, preferably 0.1 to 2% by weight, particularly preferably 0.2 to 1.5% by weight, particularly 0.5 to 1.0% by weight of adenosine; up to 5% by weight, preferably less than 1% by weight, particularly preferably less than 0.5% by weight of ethanol; and preferably 0.1 to 5% by weight, particularly preferably 0.3 to 3% by weight, particularly 0.5 to 2% by weight of cocamidopropyl betaine.

[0046] A particularly preferred subject is a water-based sprayable hair supplement comprising: 2.0 to 7.0% by weight, particularly 2.0 to 5.0% by weight, of urea and optionally 2-hydroxyethylurea; 0.2 to 1.5% by weight, particularly 0.5 to 1.0% by weight, of adenosine; less than 0.5% by weight of ethanol; and preferably 0.5 to 2% by weight of cocamidopropyl betaine.

[0047] For all embodiments in which 2-hydroxyethylurea is used alone or in combination with urea, it is preferred that the composition contains additional excipients. Particularly preferred are the presence of an amino alcohol (preferably 2-aminoethanol) and / or a lactate (preferably ammonium lactate) in embodiments containing 2-hydroxyethylurea or embodiments containing both 2-hydroxyethylurea and urea. In this case, it is particularly preferred that the ratio of 2-hydroxyethylurea to 2-aminoethanol is from 100:1 to 50:1. In this case, it is particularly preferred that the ratio of 2-hydroxyethylurea to ammonium lactate is from 15:1 to 25:1.

[0048] In addition to the excipients mentioned above, the hair supplements for which protection is sought may contain other ingredients such as fragrances or perfumes, extracts (especially plant extracts), preservatives, pH adjusters, dyes, other detergent substances, and mixtures thereof.

[0049] Preferably, the claimed product has a pH value of 3.0 to 8.3 at 20°C, more preferably 3.0 to 7.0, particularly preferably 4.0 to 6.0, and especially 4.2 to 5.5. All pH values ​​given in this application are applicable to measurements at 20°C.

[0050] Therefore, a further preferred subject is an aqueous sprayable hair supplement comprising: 1.0 to 20% by weight, preferably 2.0 to 7.0% by weight, particularly 2.0 to 5.0% by weight of urea and / or 2-hydroxyethylurea; 0.05 to 3% by weight, preferably 0.1 to 2% by weight, particularly preferably 0.2 to 1.5% by weight, particularly 0.5 to 1.0% by weight of adenosine; and 5.0 to 10% by weight of ethanol, wherein the pH of the product is 3.0 to 7.0, preferably 4.0 to 6.0, particularly 4.2 to 5.5.

[0051] Therefore, a further preferred subject is an aqueous sprayable hair conditioner comprising: 1.0 to 15 or 20% by weight, preferably 2.0 to 7.0% by weight, particularly 2.0 to 5.0% by weight, of urea and / or urea derivatives; 0.05 to 3% by weight, preferably 0.1 to 2% by weight, particularly preferably 0.2 to 1.5% by weight, particularly 0.5 to 1.0% by weight, of adenosine; up to 5% by weight, preferably less than 1% by weight, particularly preferably less than 0.5% by weight, of ethanol; and at least one excipient selected from glycols, polyethylene glycols, glycol ethers, glycerin, polyglycerol derivatives, amine oxides, betaine, amino alcohols and lactates, or mixtures thereof, preferably 0.5 to 20% by weight, particularly preferably up to 15% by weight, particularly up to 10% by weight.

[0052] Therefore, a further particularly preferred subject is an aqueous sprayable hair supplement comprising: 2.0 to 7.0% by weight, particularly 2.0 to 5.0% by weight, of urea and / or 2-hydroxyethylurea; 0.2 to 1.5% by weight, particularly 0.5 to 1.0% by weight, of adenosine; less than 0.5% by weight, of ethanol; and preferably 5 to 10% by weight, of 1,2-propanediol, wherein the aqueous sprayable hair supplement has a pH of 3.0 to 7.0, preferably 4.0 to 6.0.

[0053] A further particularly preferred subject is a water-based sprayable hair supplement comprising: 2.0 to 7.0% by weight, particularly 2.0 to 5.0% by weight, of urea and / or 2-hydroxyethylurea; 0.2 to 1.5% by weight, particularly 0.5 to 1.0% by weight, of adenosine; less than 0.5% by weight, of ethanol; and preferably 1 to 3.5% by weight, of 1,2-pentanediol, wherein the pH of the water-based sprayable hair supplement is 3.0 to 7.0, preferably 4.0 to 6.0.

[0054] A further particularly preferred subject is a water-based sprayable hair supplement comprising: 2.0 to 7.0% by weight, particularly 2.0 to 5.0% by weight, of urea and / or 2-hydroxyethylurea; 0.2 to 1.5% by weight, particularly 0.5 to 1.0% by weight, of adenosine; less than 0.5% by weight of ethanol; and a mixture of polyglycerol-6 octanoate and polyglycerol-4 decanoate, wherein the pH of the water-based sprayable hair supplement is 3.0 to 7.0, preferably 4.0 to 6.0.

[0055] A further particularly preferred subject is an aqueous sprayable hair supplement comprising: 2.0 to 7.0% by weight, particularly 2.0 to 5.0% by weight, of urea and / or 2-hydroxyethylurea; 0.2 to 1.5% by weight, particularly 0.5 to 1.0% by weight, of adenosine; less than 0.5% by weight, of ethanol; and preferably 0.5 to 2% by weight, of dodecyl dimethylamine oxide, wherein the aqueous sprayable hair supplement has a pH of 3.0 to 7.0, preferably 4.0 to 6.0.

[0056] A further particularly preferred subject is an aqueous sprayable hair supplement comprising: 2.0 to 7.0% by weight, particularly 2.0 to 5.0% by weight, of urea and / or 2-hydroxyethylurea; 0.2 to 1.5% by weight, particularly 0.5 to 1.0% by weight, of adenosine; less than 0.5% by weight, of ethanol; and preferably 0.5 to 2% by weight, of cocamidopropyl betaine, wherein the aqueous sprayable hair supplement has a pH of 3.0 to 7.0, preferably 4.0 to 6.0.

[0057] Another subject of this application is the use of the claimed product as a hair supplement.

[0058] The above have already demonstrated stable aqueous compositions containing high concentrations of adenosine. Therefore, another subject of this application is the use of urea and / or urea derivatives for stabilizing adenosine in aqueous compositions containing less than 18% by weight of ethanol. Therefore, another subject of this application is the use of urea and / or urea derivatives and excipients for stabilizing adenosine in aqueous compositions containing up to 5% by weight of ethanol, said excipients being selected from glycols, polyethylene glycols, glycol ethers, glycerol, polyglycerol derivatives, amine oxides, betaine, amino alcohols, and lactates, or mixtures thereof.

[0059] Therefore, another subject matter of this application is the use of a sprayable aqueous formulation containing adenosine and urea and / or urea derivatives with an ethanol content of less than 18% by weight for cosmetic treatment of the skin, particularly the scalp. Therefore, another subject matter of this application is the use of a sprayable aqueous formulation containing adenosine, urea and / or urea derivatives, and excipients with an ethanol content of less than 18% by weight for cosmetic treatment of the skin, particularly the scalp, wherein the excipients are selected from glycols, polyethylene glycols, glycol ethers, glycerin, polyglycerol derivatives, amine oxides, betaine, amino alcohols, and lactates, or mixtures thereof.

[0060] All other features of the claimed composition can be adapted accordingly for these uses.

[0061] All information provided for the product also applies directly to the intended use. This applies in particular, but not exclusively, to data and characteristics of urea (derivatives), adenosine, excipients, ethanol content, viscosity, pH value, measurement methods, and other specified components.

[0062] The invention is further described (but not exhaustively) by the following entries: Item 1: A water-based sprayable hair supplement comprising 1.0 to 20% by weight of urea and / or urea derivatives, and 0.05 to 3% by weight of adenosine, wherein the hair supplement comprises less than 18% by weight, preferably up to 10% by weight, and particularly up to 5% by weight of ethanol.

[0063] Item 2: The product according to Item 1, wherein the urea derivative is 2-hydroxyethylurea.

[0064] Item 3: A product according to any one of the preceding items, wherein the product comprises at least one excipient from: glycol, polyethylene glycol, glycol ether, glycerol, polyglycerol derivative, amine oxide, betaine, amino alcohol and lactate, or mixtures thereof.

[0065] Item 4: The product according to Item 3, wherein the diol is ethylene glycol, 1,2-propanediol, 1,3-propanediol, 1,2-butanediol, 1,2-pentanediol, or dipropylene glycol, or a mixture thereof.

[0066] Item 5: The product according to Item 3, wherein the polyethylene glycol is derived from the product according to the formula HO-[CH2CH2O]. x One or more compounds of -H, wherein x is an integer from 2 to 100, preferably from 2 to 80, more preferably from 2 to 60, or even more preferably from 3 to 40 or from 4 to 20.

[0067] Item 6: The product according to Item 3, wherein the polyglycerol derivative is at least one of the polyglycerol derivatives known by the INCI names polyglycerol-6 octanoate, polyglycerol-4 decanoate, polyglycerol-3 cocoate, polyglycerol-6 ricinoleate, or polyglycerol-3 decanoate / octanoate / succinate, or mixtures thereof.

[0068] Item 7: The product according to Item 3, wherein the amine oxide is at least one of (C5-C18 alkyl) dimethylamine oxide or a mixture thereof.

[0069] Item 8: The product according to Item 3, wherein the betaine is derived from the formula R-CO-NH-(CH2)3-N + (CH3)2-CH2COO - One or more compounds, wherein R is a C5 to C21 alkyl chain.

[0070] Item 9: The product according to Item 3, wherein the amino alcohol is 2-aminoethanol, and / or the lactate is ammonium lactate.

[0071] Item 10: A product according to any one of items 3-9, wherein the product contains up to 5% by weight, preferably less than 1% by weight, of ethanol, and in particular does not contain ethanol.

[0072] Item 11: A product according to any of the preceding items, wherein the product comprises less than 0.5% by weight of one or more components derived from 5'-adenosine phosphate.

[0073] Item 12: The product according to any one of the preceding items, wherein the product comprises 0.1 to 2.0% by weight, preferably 0.1 to 1.0% by weight, of adenosine.

[0074] Item 13: The product according to any one of the preceding items, wherein the total amount of said urea and / or urea derivative is 1.0 to 15% by weight, preferably 2.0 to 7.0% by weight, more preferably 2.0 to 5.0% by weight.

[0075] Item 14: A product according to any one of items 3-13, wherein one or more excipients are present in a total amount of 0.5 to 35% by weight, preferably in an amount of up to 25% by weight.

[0076] Item 15: A product according to any one of the preceding items, wherein the viscosity of the product, as measured by a Brookfield rotational viscometer (DV1 type, rotor 1, 20 RPM), is at most 150 mPa*s, particularly preferably 0.8 to 50 mPa*s, and especially 1.0 to 20.0 mPa*s.

[0077] Item 16: The product according to any one of the preceding items, wherein the pH of the product at 20°C is 3.0 to 8.3, preferably 3.0 to 7.0, particularly preferably 4.0 to 6.0, especially 4.2 to 5.5.

[0078] Item 17: Use of urea and / or urea derivatives for stabilizing adenosine in aqueous compositions containing less than 18% by weight of ethanol.

[0079] Item 18: Use of a sprayable aqueous formulation containing adenosine and urea and / or urea derivatives with an ethanol content of less than 18% by weight for cosmetic treatment of the skin, especially the scalp.

[0080] Exemplary Implementation Compositions E1 to E13 are prepared as follows: Dissolve adenosine in water at 50°C. Optionally, dissolve a preservative (such as sodium benzoate) in the solution at 50°C. Optionally, then add ethanol. Add and dissolve all other components except urea and / or urea derivatives. Then cool the solution to below 25°C. Add urea and / or urea derivatives to the solution at a temperature of 20 to 25°C and dissolve.

[0081] Prepare compositions V1 to V6 as described above.

[0082] Table 1

[0083] Table 2

[0084] Table 3

[0085] 1 INCI: Hydroxyethylurea (Hydrovance: Preparation of Hydroxyethylurea) 2 INCI: Polyglycerol-6-octanoate (and) polyglycerol-4-decanoate 3 INCI: Laurylamine oxide The pH of the compositions was determined immediately after preparation. The resulting compositions were stored at 0°C, room temperature (20°C), and 40°C ("+": storage stable; "n": not storage stable). Visual inspection showed that all compositions E1 to E13 were stable for at least 3 weeks at all test temperatures. Comparative compositions V1 to V6 were unstable during this period or only under certain conditions, with precipitation forming.

Claims

1. A water-based sprayable hair conditioner, said water-based sprayable hair conditioner comprising 1.0 to 20% by weight of urea and / or urea derivatives, 0.05 to 3% by weight of adenosine, and a buffer system for stabilizing pH, characterized in that, The hair supplement contains less than 18% by weight, preferably up to 10% by weight, and particularly up to 5% by weight of ethanol.

2. The product according to claim 1, wherein the urea derivative is 2-hydroxyethylurea, and / or the total amount of the urea and / or urea derivative is 1.0 to 15% by weight, preferably 2.0 to 7.0% by weight, more preferably 2.0 to 5.0% by weight.

3. The product according to any one of the preceding claims, wherein the product comprises at least one excipient derived from: glycol, polyethylene glycol, glycol ether, glycerol, polyglycerol derivative, amine oxide, betaine, amino alcohol and lactate, or mixtures thereof.

4. The product according to claim 3, wherein the diol is ethylene glycol, 1,2-propanediol, 1,3-propanediol, 1,2-butanediol, 1,2-pentanediol, or dipropylene glycol, or a mixture thereof.

5. The product according to claim 3, wherein the polymerized polyglycerol derivative is at least one of the following: polyglycerol-6 caprylate, polyglycerol-4 decanoate, polyglycerol-3 cocoate, polyglycerol-6 ricinoleate, or polyglycerol-3 decanoate / caprylate / succinate, or mixtures thereof, under the INCI names polyglycerol-6 caprylate, polyglycerol-4 decanoate, polyglycerol-3 cocoate, polyglycerol-6 ricinoleate, or polyglycerol-3 decanoate / caprylate / succinate.

6. The product according to any one of claims 3-5, wherein the product contains up to 5% by weight, preferably less than 1% by weight, of ethanol, and in particular does not contain ethanol.

7. The product according to any one of the preceding claims, wherein the product comprises 0.1 to 2.0% by weight, preferably 0.1 to 1.0% by weight, of adenosine.

8. The product according to any one of the preceding claims, wherein the viscosity of the product, as measured by a Brookfield rotational viscometer (DV1 type, rotor 1, 20 RPM), is at most 150 mPa*s, particularly preferably 0.8 to 50 mPa*s, and especially 1.0 to 20.0 mPa*s.

9. The product according to any one of the preceding claims, wherein the product has a pH value of 3.0 to 7.0 at 20°C.

10. A sprayable aqueous formulation containing adenosine and urea and / or urea derivatives with an ethanol content of less than 18% by weight, for use in cosmetic treatment of the skin, especially the scalp.

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