Cosmetic agent containing adenosine

Abstract

This invention relates to a sprayable hair care product in the form of an oil-in-water emulsion, comprising at least one water-insoluble oil component (A), at least one nonionic emulsifier (B), at least one nonionic co-emulsifier (C), and water, wherein the water content is 60-90% by weight, the content of component (A) is 1.5-20% by weight, and the total content of components (B) and (C) is 1-12% by weight. A key feature of this invention is that the adenosine content is 0.01-3% by weight, and the total content of urea and / or urea derivatives is 1.0-25% by weight. This invention also relates to a method for preparing a sprayable aqueous adenosine formulation, wherein an aqueous adenosine solution is mixed with a finely dispersed emulsion of an oil component (A), the average droplet diameter of which is less than 1 μm (measured using a device based on the principle of semi-elastic light scattering (Zetasizer Nano ZS, 25°C, square polystyrene cuvette, 12 mm side length (model DTS0012), dilution: 0.025% w / w in water)), and the amount of which is such that the formulation contains 1.5 to 20% by weight of the emulsified oil component (A). During or after preparation and before mixing with the adenosine solution, the emulsion is heated to the phase inversion temperature, and urea and / or urea derivatives are added to the resulting mixture at room temperature. This invention also relates to a sprayable aqueous formulation containing adenosine and urea and / or urea derivatives and having an ethanol content of less than 18% by weight for use in cosmetic treatments of the skin, particularly the scalp.

Description

[0001] This invention relates to the field of hair care products. Specifically, it relates to a sprayable, water-based agent containing adenosine and possessing skin and hair care benefits.

[0002] This invention relates to a hair care agent with hair-protecting effects, such as preventing hair loss and promoting hair growth. Adenosine is an active ingredient used in various cosmetic formulations (e.g., hair care agents) to prevent hair loss and promote hair growth. Such agents are preferably sprayed onto the scalp and hair for ease of use and do not add weight to the hair during application.

[0003] To achieve satisfactory results for users, these products ideally require a high concentration of adenosine. Currently, only spray-on products with an ethanol content of at least 20% by weight can achieve a high concentration of adenosine (0.1-1.5% by weight). Adenosine cannot be stably incorporated into spray-on products with significantly lower ethanol content. However, such high alcohol content can cause severe scalp dryness and accelerate hair dye fading. Therefore, we aim to provide a product that overcomes these drawbacks.

[0004] Therefore, the object of the present invention is to provide a stable sprayable water-containing reagent with a high concentration of adenosine that does not dry out the scalp.

[0005] Surprisingly, it was discovered that this task could be accomplished using an oil-in-water emulsion containing adenosine.

[0006] Therefore, the first subject of this application is a sprayable hair care product in the form of an oil-in-water emulsion, comprising at least one water-insoluble oil component (A), at least one nonionic emulsifier (B), at least one nonionic co-emulsifier (C), and water, wherein Water content is 60-90% by weight The content of component (A) is 1.5-20% by weight, and The total content of components (B) and (C) is 1-12% by weight. The adenosine content is 0.01-3% by weight, and the total content of urea and / or urea derivatives is 1.0-25% by weight.

[0007] The water-insoluble oil component (A) in the reagent according to the invention comprises 1.5-20% by weight, preferably 3.5-15% by weight, and particularly preferably 5-10% by weight. The water-insoluble oil component (A) is preferably selected from the group consisting of fatty acid esters with an alkyl chain length of C8 to C36, natural or synthetic triglycerides, hydrocarbons that are liquid at 20°C and 1013 mbar, and mixtures thereof.

[0008] Fatty acid esters with an alkyl chain length of C8 to C36 are preferably fatty acid esters esterified with saturated alcohols with an alkyl chain length of C3 to C26. For example, saturated C3 to C26 alcohols are preferred. 12-18 Caprylic acid ester (C8OOH) / decanoic acid ester (C8OOH) of fatty alcohols 10 OOH) and / or isopropyl myristate. The amount of these fatty acid esters is preferably 5-20% by weight, particularly preferably 7-15% by weight, based on the reagent of the present invention.

[0009] Natural triglycerides can be vegetable triglycerides, such as olive oil, almond oil, peanut oil, sunflower oil, soybean oil, rapeseed oil, palm oil, or the liquid portion of coconut oil or palm kernel oil, or mixtures thereof. Natural triglycerides can also be animal-derived triglycerides, such as the liquid portion of cow's hoof oil and / or tallow. If natural triglycerides are used, vegetable triglycerides are preferred according to the present invention. Synthetic triglycerides can be triglycerides obtained by esterifying glycerol with fatty acids having 8-22 carbon atoms, such as triglycerides of a mixture of caprylic and capric acids, triglycerides of industrial oleic acid or a mixture of palmitic and oleic acids, or mixtures thereof.

[0010] Natural or synthetic triglycerides, fatty acid esters, or mixtures thereof are preferably those that are liquid at 20°C and 1013 mbar. However, triglycerides with higher melting points and esters conforming to the above chemical formulas may also be used, in an amount that keeps the oil component mixture liquid at 20°C and 1013 mbar. The amount of these triglycerides is preferably 1.5-20% by weight, particularly preferably 3.5-15% by weight, based on the reagent of the present invention.

[0011] The hydrocarbons that are liquid at 20°C and 1013 mbar can be C11 to C16 hydrocarbons, such as straight-chain C11 to C16 hydrocarbons or branched C11 to C16 hydrocarbons. They are preferably, for example, mixtures of n-undecane and n-tetane or isododecane and / or isohexadecane. The amount of these hydrocarbons used is preferably 5-20% by weight, particularly preferably 7-15% by weight, based on the reagent of the present invention.

[0012] Another preferred subject is the reagent listed above, wherein the water-soluble oil component (A) contains saturated C 12-18 Caprylic acid ester (C8OOH) / decanoic acid ester (C8OOH) of fatty alcohols 10 A mixture of triglycerides of (OOH) and a mixture of octanoic acid and caprylic acid, preferably in a content of 2.0-10% by weight.

[0013] Therefore, another preferred subject is the reagent listed above, wherein the water-soluble oil component (A) is selected from fatty acid esters with an alkyl chain length of C8 to C36, natural or synthetic triglycerides, hydrocarbons that are liquid at 20°C and 1013 mbar, and mixtures thereof.

[0014] The reagent of the present invention comprises at least one nonionic emulsifier (B) and at least one nonionic co-emulsifier (C), with a total content of 1-12% by weight. The total amount of nonionic emulsifier (B) and nonionic co-emulsifier (C) in the reagent of the present invention is preferably 3.0-10% by weight, and particularly preferably 5.0-8.0% by weight.

[0015] The at least one nonionic emulsifier (B) is preferably selected from one or more representatives of the group consisting of alkoxylated C8-C22 fatty alcohols, more preferably alkoxylated C16-C22 fatty alcohols. Ethoxylated C8-C22 fatty alcohols having 8 to 26 EOs are particularly preferred, and ethoxylated C16-C18 fatty alcohols having 12 to 20 EOs are especially preferred.

[0016] The at least one nonionic emulsifier (B) is preferably one or more alkyl polyglucosides. In this case, C8 to C18 polyglucosides are preferred, and lauryl glucoside, decyl glucoside, cocoyl glucoside, or mixtures thereof are particularly preferred.

[0017] More preferably, at least one nonionic emulsifier (B) has an HLB value of 10 to 18.

[0018] Therefore, the preferred subject is the reagents listed above, wherein at least one nonionic emulsifier (B) comprises one or more representatives selected from alkoxylated C16-C22 fatty alcohols.

[0019] Therefore, a further preferred subject is the reagents listed above, wherein at least one nonionic emulsifier (B) comprises one or more alkyl polyglucosides.

[0020] Therefore, a further preferred subject is the reagents listed above, wherein at least one nonionic emulsifier (B) has an HLB value of 10 to 18.

[0021] Therefore, another preferred subject is the reagents listed above, wherein at least one nonionic emulsifier (B) comprises a mixture of alkoxylated C8-C22 fatty alcohols and / or C8-C16 polydextrose glycosides.

[0022] Furthermore, a mixture containing different nonionic emulsifiers (B) is also preferred.

[0023] Another preferred subject is the reagent as described above, wherein the nonionic emulsifier (B) comprises a mixture of polyethylene glycol ether of cetearyl alcohol (20EO) and polyethylene glycol ether of cetearyl alcohol (12EO).

[0024] At least one nonionic co-emulsifier (C) is preferably selected from one or more of the following: C8-C22 monofatty acid esters of glycerol, C10-C18 monofatty acid esters of sorbitol, C12-C22 fatty alcohols, and mixtures thereof.

[0025] The at least one nonionic co-emulsifier (C) is preferably a C8-C22 monofatty acid ester of glycerol or a mixture thereof, particularly preferably glyceryl monostearate, glyceryl monolaurate, glyceryl caprylate or a mixture thereof.

[0026] The at least one nonionic co-emulsifier (C) is preferably a C10-C18 monofatty acid ester of sorbitol or a mixture thereof, particularly preferably sorbitol monolaurate, sorbitol monooleate, sorbitol monostearate or a mixture thereof.

[0027] The at least one nonionic co-emulsifier (C) is preferably a C12-C22 fatty alcohol, and more preferably cetearyl alcohol, myristyl alcohol, betaine alcohol, or a mixture thereof.

[0028] Therefore, the preferred subject is the reagents listed above, wherein at least one nonionic co-emulsifier (C) comprises one or more representatives of the group consisting of C8-C22 monofatty acid esters from glycerol, C10-C18 monofatty acid esters from sorbitol, C12-C22 fatty alcohols, and mixtures thereof.

[0029] Therefore, another preferred subject is the reagent listed above, wherein at least one nonionic co-emulsifier (C) comprises a C12-C22 monofatty acid ester of glycerol or a mixture thereof, particularly preferably glyceryl monostearate.

[0030] Therefore, another preferred subject is the reagent listed above, wherein at least one nonionic co-emulsifier (C) comprises a C10-C18 monofatty acid ester of sorbitol or a mixture thereof, particularly preferably sorbitol monolaurate, sorbitol monooleate, sorbitol monostearate or a mixture thereof.

[0031] Therefore, another preferred subject is the reagents listed above, wherein at least one nonionic co-emulsifier (C) includes C12-C22 fatty alcohols or mixtures thereof, with cetearyl alcohol being particularly preferred.

[0032] Furthermore, mixtures with different nonionic co-emulsifiers (C) are also preferred.

[0033] Therefore, another preferred subject is the reagent listed above, wherein the nonionic co-emulsifier (C) comprises a mixture of monofatty acid esters of glycerol (mainly including glycerides of stearic acid (C18) and palmitic acid (C16) (INCI: glyceryl monostearate)) and cetearyl alcohol.

[0034] Therefore, another preferred subject is the reagents listed above, wherein The nonionic emulsifier (B) comprises a mixture of polyethylene glycol ether of cetearyl alcohol (20EO) and polyethylene glycol ether of cetearyl alcohol (12EO). The nonionic co-emulsifier (C) comprises a mixture of mono-fatty acid esters of glycerol (mainly including glycerol esters of stearic acid (C18) and palmitic acid (C16) (INCI: glycerol monostearate)) and cetearyl alcohol, and the total amount of components (B) and (C) is preferably 3.0-10% by weight, particularly preferably 5.0-8.0% by weight.

[0035] Therefore, another preferred subject is the reagents listed above, wherein The nonionic emulsifier (B) comprises a mixture of polyethylene glycol ether of cetearyl alcohol (20EO) and polyethylene glycol ether of cetearyl alcohol (12EO). Nonionic coemulsifiers (C) comprise a mixture of monoglyceride esters of glycerol (primarily glycerides of stearic acid (C18) and palmitic acid (C16) (INCI: glyceryl monostearate)) and cetearyl alcohol, and Water-soluble oil component (A) includes saturated C 12-18 Caprylic acid ester (C8OOH) / decanoic acid ester (C8OOH) of fatty alcohols 10 A mixture of triglycerides containing OOH and a mixture of caprylic / capric acid and capric acid, or saturated C 12-18 Caprylic acid ester (C8OOH) / decanoic acid ester (C8OOH) of fatty alcohols 10 OOH), or a mixture of n-undecane and n-tetrazane, or isopropyl myristate.

[0036] Urea derivatives can be used in combination with urea or as a substitute for urea, wherein the total content is maintained at 1.0-25% by weight. According to the invention, the total amount of urea and / or urea derivatives is preferably 1.0 to 15% by weight, more preferably 2.0 to 8.0% by weight, and even more preferably 3.0 to 6.0% by weight. If a urea derivative is used, 2-hydroxyethyl urea is preferred. In these cases, the amount of 2-hydroxyethyl urea is preferably 1.0 to 15% by weight, particularly preferably 2.0 to 7.0% by weight, and especially 2.0 to 5.0% by weight. 2-hydroxyethyl urea is preferably used in combination with urea. In these cases, the preferred amount of urea is 0.05 to 3.0% by weight, particularly preferably 0.1 to 1.0% by weight, and especially 0.1 to 0.5% by weight, and the preferred amount of 2-hydroxyethyl urea is 1.0 to 15% by weight, particularly preferably 1.5 to 7% by weight, and especially 2.0 to 5.0% by weight. In such combinations, the ratio of 2-hydroxyethyl urea to urea is particularly preferably 20:1 to 10:1.

[0037] Therefore, the preferred subject is the aforementioned hair growth agent, wherein the urea derivative is 2-hydroxyethylurea.

[0038] A further preferred subject is the aforementioned hair growth agent, wherein the total amount of urea and / or urea derivatives is 1.0 to 15% by weight, preferably 2.0 to 8.0% by weight, more preferably 3.0 to 6.0% by weight.

[0039] The claimed hair care product contains 0.01 to 3.0% by weight of adenosine. Adenosine is a nucleotide composed of the nucleobases adenine and β-D-ribose. Preferred hair care products contain 0.05 to 3.0% by weight of adenosine, particularly preferably 0.1 to 2% by weight, and especially preferably 0.1 to 1.0% by weight. Furthermore, hair care products containing 0.2 to 1.5% by weight of adenosine, especially 0.5 to 1.0% by weight, are also preferred.

[0040] Therefore, it is preferred if the adenosine content in the hair growth product is 0.1 to 2.0% by weight, especially 0.1 to 1.0% by weight.

[0041] The claimed hair care product contains adenosine as an active ingredient. The hair care product may also contain adenosine derivatives, such as 5'-adenosine monophosphate (INCI), 5'-phosphate, and / or 5'-phosphate (INCI). Preferably, the claimed hair care product contains only a limited amount of adenosine derivatives, such as 5'-phosphate, such as adenosine monophosphate (INCI: adenosine monophosphate), adenosine diphosphate, and / or adenosine triphosphate (INCI: adenosine triphosphate). Preferably, the adenosine monophosphate content of the hair care product is less than 0.5% by weight, particularly preferably less than 0.2% by weight, especially preferably less than 0.1% by weight. Particularly preferably, the hair care product is free of adenosine monophosphate. In this context, "free of adenosine monophosphate" means that adenosine monophosphate is neither added as a separate ingredient nor introduced into the claimed reagent through formulations of other ingredients, for example, in a content not exceeding 0.001% by weight, based on the total mass of the reagent.

[0042] Therefore, the preferred subject is a hair growth agent containing less than 0.5% by weight, particularly preferably less than 0.2% by weight, especially less than 0.1% by weight, of one or more ingredients selected from 5'-adenosine phosphate.

[0043] Therefore, the preferred subject is also a hair care product containing adenosine, with an adenosine content of 0.05 to 3.0% by weight, particularly preferably 0.1 to 2% by weight, especially 0.1 to 1.0% by weight.

[0044] Therefore, another preferred subject is the reagents listed above, wherein The nonionic emulsifier (B) comprises a mixture of polyethylene glycol ether of cetearyl alcohol (20EO) and polyethylene glycol ether of cetearyl alcohol (12EO). Nonionic coemulsifiers (C) include monoglycerides of glycerol (primarily glycerides of stearic acid (C18) and palmitic acid (C16) (INCI: glyceryl monostearate)) and a mixture of cetearyl alcohol, and Water-soluble oil component (A) is saturated C 12-18 Caprylic acid ester (C8OOH) / decanoic acid ester (C8OOH) of fatty alcohols 10 A mixture of triglycerides containing OOH and a mixture of caprylic / capric acid and capric acid, or saturated C 12-18 Caprylic acid ester (C8OOH) / decanoic acid ester (C8OOH) of fatty alcohols 10 OOH), or a mixture of n-undecane and n-tridecane, or isopropyl myristate, and The adenosine content is 0.05 to 3.0 by weight, particularly preferably 0.1 to 2 by weight, especially 0.5 to 1.0 by weight.

[0045] Therefore, another preferred subject is the reagents listed above, wherein The nonionic emulsifier (B) comprises a mixture of polyethylene glycol ether of cetearyl alcohol (20EO) and polyethylene glycol ether of cetearyl alcohol (12EO). Nonionic coemulsifiers (C) include monoglycerides of glycerol (primarily glycerides of stearic acid (C18) and palmitic acid (C16) (INCI: glyceryl monostearate)) and a mixture of cetearyl alcohol, and Water-soluble oil component (A) contains saturated C 12-18 Caprylic acid ester (C8OOH) / decanoic acid ester (C8OOH) of fatty alcohols 10 A mixture of triglycerides containing OOH and a mixture of caprylic / capric acid and capric acid, or saturated C 12-18 Caprylic acid ester (C8OOH) / decanoic acid ester (C8OOH) of fatty alcohols 10 OOH), or a mixture of n-undecane and n-tridecane, or isopropyl myristate, and The adenosine content is 0.05 to 3.0% by weight, particularly preferably 0.1 to 2% by weight, especially 0.5 to 1.0% by weight, and it contains less than 0.5% by weight, particularly preferably less than 0.2% by weight, especially less than 0.1% by weight of one or more components selected from 5'-adenosine phosphate.

[0046] In the aqueous embodiment, the water content is 60 to 90% by weight. In the preferred embodiment, the water content is 70 to 80% by weight. The main function of the water is to adjust the concentration of the aforementioned components to a suitable range for the aqueous spray hair conditioner.

[0047] Preferably, the claimed reagent has a pH value of 3.0 to 7.0 at 20°C, more preferably 4.0 to 6.0, and particularly preferably 4.5 to 5.5. Therefore, the preferred subject matter is the reagent as described above, wherein the reagent has a pH value of 3.0 to 7.0 at 20°C, more preferably 4.0 to 6.0, and particularly preferably 4.5 to 5.5. All pH values ​​described in this application are applicable to measurements taken at 20°C.

[0048] To ensure better skin compatibility compared to compositions with high ethanol content, the hair care product claimed to contain less than 18% by weight of ethanol, particularly preferably up to 10% by weight, and especially preferably up to 5% by weight of ethanol.

[0049] Therefore, the preferred subject is a hair care agent as described above, which contains less than 18% by weight, particularly preferably up to 10% by weight, and especially preferably up to 5% by weight of ethanol.

[0050] Furthermore, it is preferred that the hair care product claimed to be protected contains at most 5% by weight, particularly preferably less than 1% by weight, especially preferably less than 0.5% by weight of ethanol, or contains no ethanol.

[0051] In this document, "ethanol-free" means that ethanol is neither added as a separate ingredient nor introduced into the claimed reagent through the formulation of other ingredients, for example, the ethanol content does not exceed 2% by weight based on the total mass of the reagent. Therefore, another preferred subject is a hair growth agent as described above, wherein the ethanol content is at most 5% by weight, particularly preferably less than 1% by weight, especially preferably less than 0.5% by weight, even more preferably less than 0.1% by weight, or ethanol-free.

[0052] The claimed hair care product may contain one or more excipients. These optional excipients can further stabilize hair care products with very low ethanol content and those that are ethanol-free. Therefore, a preferred subject is a hair care product containing at least one excipient selected from glycols, glycol ethers, and glycerin, or mixtures thereof. A preferred subject is also a hair care product as described above, containing up to 5% by weight, particularly preferably less than 1% by weight, especially preferably less than 0.5% by weight, and even more preferably less than 0.1% by weight of ethanol and at least one excipient selected from glycols, glycol ethers, and glycerin, or mixtures thereof.

[0053] The hair care product of the present invention, which optionally contains such excipients, preferably contains a total amount of 1 to 20% by weight, preferably up to 15% by weight, and particularly up to 10% by weight.

[0054] Therefore, the preferred subject is a protective hair growth agent that additionally contains at least one diol as an optional excipient. The diol is preferably ethylene glycol, 1,2-propanediol, 1,3-propanediol, 1,2-butanediol, 1,2-pentanediol, or dipropylene glycol, or mixtures thereof.

[0055] If at least one diol is used as an excipient, the total content of the diol or mixture of several diols in the claimed reagent is preferably 0.5 to 15% by weight. The diol is particularly preferably 1,2-propanediol and / or 1,2-pentanediol. If 1,2-propanediol is used as an excipient, its content in the claimed reagent is preferably 2 to 20% by weight, particularly preferably 3 to 15% by weight. If 1,2-pentanediol is used as an excipient, its content in the claimed reagent is preferably 0.5 to 5% by weight, particularly preferably 1 to 3.5% by weight.

[0056] Therefore, another preferred subject is a claimed hair growth agent that also comprises at least one glycol ether as an optional excipient. The glycol ether is preferably one or more compounds selected from monomethyl ether, monoethyl ether, monopropyl ether, and mixtures thereof. If a glycol ether is used as an optional excipient, its total content in the claimed reagent is preferably 0.5 to 15% by weight. The optional glycol ether is particularly preferably diethylene glycol monoethyl ether. If diethylene glycol monoethyl ether is used, its content in the claimed reagent is preferably 0.5 to 15% by weight, particularly preferably 5.0 to 10% by weight.

[0057] Therefore, another preferred subject is a protected hair growth agent that also contains glycerin as an optional excipient. If glycerin is used as an optional excipient, its content in the protected agent is preferably 0.5 to 15% by weight, particularly preferably 5.0 to 10% by weight.

[0058] To ensure the stability of the composition and achieve a fine distribution of components, it is important that the oil component (A) exists in the emulsion as small droplets. According to the invention, it is preferred that the average droplet diameter of the oil component (A) is less than 1 μm, more preferably less than 600 nm, and even more preferably less than 300 nm (measured using a device based on the principle of quasi-elastic light scattering (Zetasizer Nano ZS, 25 °C, square polystyrene cuvette, 12 mm side length (model DTS0012), dilution: 0.025% w / w in water)).

[0059] Therefore, the preferred subject is a hair care product requiring protection, wherein the average droplet diameter of the oil component (A) is less than 1 μm, preferably less than 600 nm, more preferably less than 300 nm, measured using a device based on the principle of quasi-elastic light scattering (Zetasizer Nano ZS, 25°C, square polystyrene cuvette, 12 mm side length (model DTS0012), dilution: 0.025% w / w in water).

[0060] The claimed water-based sprayable hair conditioner is easy for the user to apply to the relevant areas because it is sprayable and therefore can be distributed finely and evenly. To ensure good sprayability, the hair treatment composition of the present invention preferably does not contain thickening agents, such as polyquaternium polymers known as INCI names polyquaternium-10 and polyquaternium-37, provided that this is economical to operate, i.e., provided that small amounts of the corresponding substances are not introduced as minor components or impurities as industry-standard ingredients. The content of such thickening agents and similar thickening agents in the hair treatment agent of the present invention is preferably no more than 2% by weight, more preferably no more than 0.5% by weight, and particularly preferably no more than 0.1% by weight, based on the total weight of the hair treatment composition.

[0061] According to the present invention, preferably, the claimed hair growth agent has a maximum strength of 150 mPa. s, preferably 0.8 to 50 mPa s, especially 1.0 to 20.0 mPa The viscosity of s was measured using a Brookfield rotational viscometer (DV1 type, rotor 1, 20 RPM) to ensure good sprayability.

[0062] Therefore, the preferred subject is a hair care product requiring protection as described above, with a viscosity of at most 150 mPa. s, particularly preferred 0.8 to 50 mPa s, especially 1.0 to 20.0 mPa s, measured using a Brookfield rotational viscometer (DV1 type, rotor 1, 20 rpm).

[0063] Compositions capable of achieving the above objectives are prepared in a specific manner. Therefore, another subject of this application is a method for preparing a sprayable aqueous adenosine formulation, wherein an aqueous adenosine solution is mixed with a finely dispersed emulsion of an oil component (A), wherein the oil component (A) has an average droplet diameter of less than 1 μm (measured using a device based on the principle of quasi-elastic light scattering (Zetasizer NanoZS, 25°C, square polystyrene cuvette, 12 mm side length (model DTS0012), dilution: 0.025% w / w in water)), and its content such that the formulation contains 1.5 to 20% by weight of the emulsified oil component (A), wherein the emulsion is placed at a phase transition temperature during or after emulsion preparation and before mixing with the adenosine solution, and urea and / or urea derivatives are added to the resulting mixture at room temperature.

[0064] In the preferred method, the average droplet diameter of the oil component (A) is preferably less than 600 nm, more preferably less than 300 nm.

[0065] Furthermore, a preferred method is to measure directly before mixing the solution and emulsion, wherein the temperature of the adenosine aqueous solution is at most 50°C, preferably at most 45°C, and / or the temperature of the finely dispersed emulsion of the oil component (A) is 30 to 50°C, preferably 30 to 40°C.

[0066] Furthermore, it is preferred to add urea and / or urea derivatives in solid form.

[0067] A particularly preferred method is one in which the finely dispersed emulsion of the oil component (A) is a PIT emulsion, the PIT emulsion further comprising at least one nonionic emulsifier (B) and at least one nonionic co-emulsifier (C).

[0068] Furthermore, the method according to the invention is preferred, wherein after adding urea and / or urea derivatives, the pH of the formulation is adjusted to a value between 3.0 and 7.0.

[0069] Therefore, the preferred subject is the claimed method as described above, wherein the temperature of the adenosine aqueous solution is at most 50°C, preferably at most 45°C, and / or the temperature of the subdivided emulsion of oil component (A) is 30 to 50°C, preferably 30 to 40°C, measured directly before mixing the solution and emulsion.

[0070] Therefore, a further preferred subject is the claimed method as described above, wherein urea and / or urea derivatives are added in solid form.

[0071] Therefore, another preferred subject matter is the claimed method as described above, wherein the finely dispersed emulsion of the oil component (A) is a PIT emulsion, said PIT emulsion further comprising at least one nonionic emulsifier (B) and at least one nonionic co-emulsifier (C).

[0072] Therefore, another preferred subject is the claimed method as described above, wherein the pH of the formulation is adjusted to a value between 3.0 and 7.0 after the addition of urea and / or urea derivatives.

[0073] Therefore, a particularly preferred subject matter is the claimed method as described above, wherein the finely dispersed emulsion of the oil component (A) is a PIT emulsion, the PIT emulsion further comprising at least one nonionic emulsifier (B) and at least one nonionic co-emulsifier (C), and wherein, after the addition of urea and / or urea derivatives, the pH of the formulation is adjusted to a value between 3.0 and 7.0, wherein, if applicable, the temperature of the adenosine aqueous solution is at most 50°C, preferably at most 45°C, and / or the temperature of the finely dispersed emulsion of the oil component (A) is 30 to 50°C, preferably 30 to 40°C, measured directly before mixing the solution and the emulsion, and wherein, if applicable, the urea and / or urea derivatives are added in solid form.

[0074] The foregoing has demonstrated stable aqueous compositions containing high concentrations of adenosine. Therefore, a further subject of this application is the use of urea and / or urea derivatives for stabilizing adenosine in aqueous emulsions with an ethanol content of less than 18% by weight. Therefore, a further subject of this application is the use of urea and / or urea derivatives, and (if applicable) excipients, for stabilizing adenosine in aqueous emulsions with an ethanol content of less than 18% by weight, said excipients being selected from glycols, polyethylene glycols, glycol ethers, glycerol, polyglycerol derivatives, amine oxides, betaine, amino alcohols, and lactates, or mixtures thereof.

[0075] Therefore, a further subject of this application is the use of a sprayable aqueous emulsion for cosmetic care of the skin, particularly the scalp, the emulsion containing adenosine and urea and / or urea derivatives and having an ethanol content of less than 18% by weight. Therefore, a further subject of this application is the use of a sprayable aqueous emulsion for cosmetic care of the skin, particularly the scalp, the emulsion containing adenosine, urea and / or urea derivatives, and optionally excipients selected from glycols, polyethylene glycol, glycol ethers, glycerin, polyglycerol derivatives, amine oxides, betaine, amino alcohols and lactates, or mixtures thereof, and having an ethanol content of less than 18% by weight.

[0076] Another subject of this application is the use of a sprayable aqueous formulation containing adenosine and urea and / or urea derivatives and having an ethanol content of less than 18% by weight for cosmetic care of the skin, particularly the scalp.

[0077] All information provided for the reagents also applies directly to the methods and uses described herein. This applies in particular (but not limited to) data and properties relating to components (A), (B), and (C), excipients, ethanol content, viscosity, pH value, measurement methods, and other specified components.

[0078] The subject matter for which protection is sought is further described by, but not limited to, the following: Project 1: A sprayable hair care product in the form of an oil-in-water emulsion, comprising at least one water-insoluble oil component (A), at least one nonionic emulsifier (B), at least one nonionic co-emulsifier (C), and water, wherein... Water content is 60-90% by weight The content of component (A) is 1.5-20% by weight, and The total content of components (B) and (C) is 1-12% by weight. The adenosine content is 0.01-3% by weight, and the total content of urea and / or urea derivatives is 1.0-25% by weight.

[0079] Item 2: The reagent according to Item 1, wherein the reagent contains less than 0.5% by weight, particularly preferably less than 0.2% by weight, especially less than 0.1% by weight, of one or more components selected from 5'-adenosine phosphate.

[0080] Clause 3: The reagent according to one of the above items, wherein the urea derivative is 2-hydroxyethylurea.

[0081] Item 4: A reagent according to one of the preceding items, wherein the reagent comprises at least one excipient selected from glycols, glycol ethers and glycerol.

[0082] Item 5: The reagent according to Item 4, wherein at least one excipient is selected from 1,2-propanediol or 1,2-pentanediol or a mixture thereof.

[0083] Item 6: According to the reagent of Item 3 or 4, the total amount of said excipient is 1 to 20% by weight, preferably up to 15% by weight, and particularly up to 10% by weight.

[0084] Item 7: The average droplet diameter of the oil component (A) is less than 1 μm, preferably less than 600 nm, more preferably less than 300 nm, according to the reagents in any of the preceding items, and is measured using a device based on the quasi-elastic light scattering principle (Zetasizer Nano ZS, 25°C, square polystyrene cuvette, 12 mm side length (model DTS0012), dilution: 0.025% w / w in water).

[0085] Project 8: A formulation according to one of the foregoing projects, wherein the viscosity of said reagent at 20°C is at most 150 mPa. s, particularly preferred at 0.8 to 50 mPa s, especially 1 to 20 mPa s, measured using a Brookfield rotational viscometer (DV1 type, rotor 1, 20 RPM).

[0086] Item 9: A reagent according to one of the preceding items, wherein the pH value of the reagent at 20°C is 3.0 to 7.0, preferably 4.0 to 6.0, and particularly preferably 4.5 to 5.5.

[0087] Item 10: According to the reagent of one of the preceding items, wherein the at least one water-soluble oil component (A) is selected from fatty acid esters with an alkyl chain length of C8 to C36, natural or synthetic triglycerides, hydrocarbons that are liquid at 20°C and 1013 mbar, and mixtures thereof.

[0088] Item 11: According to the reagent of one of the preceding items, at least one nonionic emulsifier (B) is selected from one or more representatives of: alkoxylated C8-C22 fatty alcohols, preferably alkoxylated C16-C22 fatty alcohols.

[0089] Item 12: According to the reagent of one of the preceding items, wherein the at least one nonionic emulsifier (B) is selected from one or more of the following: alkyl polyglucosides.

[0090] Item 13: According to the reagent of one of the preceding items, the HLB value of the at least one nonionic emulsifier (B) is 10 to 18.

[0091] Item 14: According to the reagent of one of the preceding items, at least one nonionic co-emulsifier (C) is selected from one or more representatives of the following: C8-C22 monofatty acid esters of glycerol, C10-C18 monofatty acid esters of sorbitol, C12-C22 fatty alcohols and mixtures thereof.

[0092] Item 15: A reagent according to one of the preceding items, wherein the reagent contains less than 18% by weight, preferably up to 10% by weight, particularly preferably up to 5% by weight, and more preferably less than 1% by weight of ethanol.

[0093] Item 16: A reagent according to one of the preceding items, wherein the reagent comprises 0.05 to 3.0% by weight, particularly preferably 0.1 to 2% by weight, especially 0.1 to 1.0% by weight of adenosine.

[0094] Project 17: A method for preparing a sprayable aqueous adenosine formulation, wherein an aqueous adenosine solution is mixed with a finely dispersed emulsion of an oil component (A), wherein the oil component (A) has an average droplet diameter of less than 1 μm (measured using a device based on the principle of quasi-elastic light scattering (Zetasizer Nano ZS, 25°C, square polystyrene cuvette, 12 mm side length (model DTS0012), dilution: 0.025% w / w in water)), and its content is such that the formulation contains 1.5 to 20% by weight of the emulsified oil component (A), wherein the emulsion is adjusted to a phase transition temperature during or after emulsion preparation and before mixing with the adenosine solution, and urea and / or urea derivatives are added to the resulting mixture at room temperature.

[0095] Item 18: Use of sprayable aqueous formulations containing adenosine and urea and / or urea derivatives and with an ethanol content of less than 18% by weight for cosmetic treatment of the skin, especially the scalp.

[0096] Example: The following compositions are provided in the same manner: During production, the (co)emulsifier, oily components, and water (in a ratio of 1:2 to 1:3) are transferred to a PIT emulsion, wherein the emulsion is heated to the phase inversion temperature during or after emulsion preparation. An aqueous adenosine solution (1.5% to 2.5%) is then added. In this case, the temperature of the PIT emulsion is at most 35°C, and the temperature of the adenosine solution is at most 50°C. After cooling to room temperature (20°C), the fragrance (optional) is added first, followed by urea or urea derivatives, and stirred or dissolved. Optional ingredients such as pH adjusters and preservatives, and (if necessary) other excipients (e.g., 1,2-propanediol) are added via the adenosine solution.

[0097] 1 INCI: Glyceryl stearate (and) cetearyl alcohol polyether-20 (and) cetearyl alcohol polyether-12 (and) cetearyl alcohol (and) cetyl palmitate 2 INCI: Cetearyl alcohol polyether-12 3 INCI: Cocoyl octanoate / decanoate 4 INCI: Undecane (and) Tridecane 5 INCI: Hydroxyethylurea (Hydrovance: Preparation of Hydroxyethylurea) It has been demonstrated that PIT emulsions containing at least urea or hydroxyethyl urea can stabilize adenosine (E1-E8) and yield sprayable compositions with suitable viscosity.

Claims

1. A sprayable hair care product in the form of an oil-in-water emulsion, comprising at least one water-insoluble oil component (A), at least one nonionic emulsifier (B), at least one nonionic co-emulsifier (C), and water, wherein: Water content is 60-90% by weight The content of component (A) is 1.5-20% by weight, and The total content of components (B) and (C) is 1-12% by weight. The adenosine content is 0.01-3% by weight, and the total content of urea and / or urea derivatives is 1.0-25% by weight.

2. The reagent according to any one of the preceding claims, wherein the reagent comprises at least one excipient selected from glycols, glycol ethers and glycerol and / or the total content of the excipients is 1-20% by weight, preferably up to 15% by weight, particularly up to 10% by weight.

3. The reagent according to any one of the preceding claims, wherein the pH of the reagent at 20°C is 3.0 to 7.0, preferably 4.0 to 6.0, and particularly preferably 4.5 to 5.

5.

4. The reagent according to any one of the preceding claims, wherein the at least one water-soluble oil component (A) is selected from fatty acid esters with an alkyl chain length of C8 to C36, natural or synthetic triglycerides, hydrocarbons that are liquid at 20°C and 1013 mbar, and mixtures thereof.

5. The reagent according to any one of the preceding claims, wherein the at least one nonionic emulsifier (B) is selected from one or more representatives of: alkoxylated C8-C22 fatty alcohols, preferably alkoxylated C16-C22 fatty alcohols.

6. The reagent according to any one of the preceding claims, wherein the at least one nonionic co-emulsifier (C) is selected from one or more representatives of: C8-C22 monofatty acid esters of glycerol, C10-C18 monofatty acid esters of sorbitol, C12-C22 fatty alcohols, and mixtures thereof.

7. The reagent according to any one of the preceding claims, wherein the reagent contains less than 18% by weight, preferably up to 10% by weight, particularly preferably up to 5% by weight, and more preferably less than 1% by weight of ethanol.

8. The reagent according to any one of the preceding claims, wherein the reagent comprises 0.05-3.0% by weight, particularly preferably 0.1-2% by weight, especially 0.1-1.0% by weight of adenosine.

9. A method for preparing a sprayable aqueous adenosine formulation, wherein an aqueous adenosine solution is mixed with a finely dispersed emulsion of an oil component (A), wherein the oil component (A) has an average droplet diameter of less than 1 μm (measured using a device based on the principle of quasi-elastic light scattering (Zetasizer Nano ZS, 25°C, square polystyrene cuvette, 12 mm side length (model DTS0012), dilution: 0.025% w / w in water), the amount of the oil component (A) such that the formulation contains 1.5-20% by weight of the emulsified oil component (A), wherein the emulsion is brought to a phase transition temperature during or after emulsion preparation and before mixing with the adenosine solution, and urea and / or urea derivatives are added to the resulting mixture at room temperature.

10. Sprayable aqueous formulations containing adenosine and urea and / or urea derivatives and with an ethanol content of less than 18% by weight for use in cosmetic treatments of the skin, particularly the scalp.

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