An intraoral drug delivery device

Abstract

This application belongs to the field of medical devices and relates to an intraoral drug delivery device. The drug delivery device includes a substrate that can be disposed on a tooth crown. The substrate has a drug storage unit. When the substrate is disposed on the tooth crown, the drug storage unit can release drug outwards. Alternatively, the drug delivery device includes an adhesive layer that can adhere to the tooth crown, the adhesive layer containing a drug mixture. By disposing the substrate on the tooth crown and having the drug storage unit disposed therein, the drug can be released, providing therapeutic or nursing effects to the tooth crown, oral cavity, or body.

Description

Technical Field

[0001] This application belongs to the field of oral care and relates to an intraoral drug delivery device. Background Technology

[0002] Currently, the main way to take oral medications is by swallowing them directly. These medications are usually broken down and absorbed in the gastrointestinal tract to exert their effects.

[0003] However, direct swallowing can easily lead to the following problems: drug toxicity side effects may fluctuate, and gastrointestinal reactions may occur. This is especially true for drugs with short half-lives or those that require frequent administration, which may result in poor therapeutic effects on the mouth, throat, lungs, and other areas. Summary of the Invention

[0004] In order to improve the therapeutic effect of this drug delivery device on the oral cavity, pharynx, lungs, gastrointestinal tract and other parts, this application provides an oral cavity drug delivery device.

[0005] The oral cavity drug delivery device provided in this application adopts the following technical solution: An intraoral drug delivery device includes a substrate that can be disposed on a tooth crown, the substrate having a drug storage unit that can release a drug when the substrate is disposed on the tooth crown; or, the drug delivery device includes an adhesive layer that can adhere to the tooth crown, the adhesive layer being mixed with and doped with a drug.

[0006] By adopting the above technical solution, the substrate is placed on the crown, and the drug storage unit can release the drug into the crown or oral cavity, or adhere the drug-containing adhesive layer to the crown to play a therapeutic role in the crown or oral cavity. At the same time, if the drug is used to treat the lungs, throat, gastrointestinal tract, etc., it can also treat the throat, lungs, gastrointestinal tract, etc. Compared with direct swallowing, it can remain near the treatment site for a longer time, slowly releasing the drug components to improve the therapeutic effect.

[0007] Preferably, one side of the substrate is provided with an adhesive layer that can adhere to the tooth crown.

[0008] By adopting the above technical solution, the substrate can be fixed to the crown through the adhesive layer.

[0009] Preferably, the adhesive layer comprises a hydrated adhesive film disposed on the substrate.

[0010] By adopting the above technical solution, the hydrated mucosa can be activated and adhered to the teeth when it comes into contact with saliva or water, thus fixing the substrate to the crown.

[0011] Preferably, the drug storage unit includes a drug mixed and doped in the adhesive layer.

[0012] Preferably, both sides of the substrate have protrusions forming snap-fit ​​pieces, and a slot is formed between the two snap-fit ​​pieces to snap onto the tooth crown.

[0013] By adopting the above technical solution, the substrate is attached to the crown through a slot, making it detachable from the crown and suitable for single use or multiple uses.

[0014] Preferably, the substrate is connected to a hand-held rod, which extends outside the oral cavity when the substrate is placed on the crown.

[0015] By adopting the above technical solution, the user can hold the hand stick and place the base on the crown.

[0016] Preferably, the drug storage unit includes a drug cavity disposed on the substrate, the drug cavity being filled with drug, and the substrate being capable of breaking under the biting force of teeth.

[0017] By adopting the above technical solution, the user's teeth occlusion can cause the matrix to rupture, releasing the drug in the cavity to treat and care for the crown or oral cavity.

[0018] Preferably, the drug storage unit includes a drug cavity disposed on the substrate, and the substrate has a drug outlet hole communicating with the drug cavity.

[0019] By adopting the above technical solution, a drug outlet is provided, and the drug in the drug cavity can be released into the oral cavity through the drug outlet. If the matrix is ​​compressed, the drug release rate will be accelerated.

[0020] Preferably, a sealing sheet is provided at the drug outlet to seal the drug outlet, and the strength of the sealing sheet is less than the strength of the housing.

[0021] By adopting the above technical solution, after the substrate is subjected to force, since the strength of the substrate is greater than the strength of the sealing sheet, the sealing sheet will break preferentially under the pressure of the drug, allowing the drug to flow out from the drug outlet.

[0022] Preferably, the substrate is flat, and the medication cavity is located at the center of the corresponding tooth crown.

[0023] By adopting the above technical solution, the medication cavity is located at the center of the tooth crown, corresponding to the matrix, which can quickly release the medication to the center of the tooth crown and improve the treatment effect.

[0024] Preferably, when the matrix is ​​placed on the crown, a drug cavity is formed between the matrix and the crown, and the drug cavity constitutes a drug storage unit.

[0025] By adopting the above technical solution, a drug cavity is formed between the matrix and the crown, thereby reducing production costs.

[0026] Preferably, the drug storage unit includes an adsorbent capable of being impregnated with a drug solution, the adsorbent being disposed on the substrate.

[0027] By adopting the above technical solution, when the user bites down, the suction device is subjected to force that can squeeze out the liquid medicine to treat the oral cavity and other parts of the body.

[0028] Preferably, the drug storage unit includes a self-volatile drug layer sprayed onto the substrate.

[0029] By adopting the above technical solution, the matrix is ​​placed behind the crown, and the self-volatile drug layer slowly releases the drug to treat and care for the crown and other parts.

[0030] Preferably, the drug storage unit includes a carrier, one side of which is fixed to the substrate, and the other side of which is coated with a drug.

[0031] By adopting the above technical solution, the drug is first sprayed onto the carrier, and then the carrier is fixed onto the substrate. When the substrate is placed on the crown, treatment and care can be performed on the crown and other parts of the tooth.

[0032] Preferably, the substrate has several pieces, and a cavity is formed between two adjacent substrates. The cavity is a drug storage unit, and the cavity is filled with drug.

[0033] By adopting the above technical solution, the drug storage unit is directly designed as a cavity between the substrates. When the substrates are engaged, they rupture, and the drug in the cavity can be released.

[0034] Preferably, the drug storage unit can release at least one of the following drug formulations: liquid, solid, semi-solid, and gaseous.

[0035] By adopting the above technical solution, the drug storage unit can release a variety of drugs, thus adapting to different diseases.

[0036] Preferably, the substrate is made of a biodegradable material and the adhesive layer is made of a starch-based material.

[0037] By adopting the above technical solutions, both biodegradable materials and starch-based materials are environmentally friendly.

[0038] Preferably, when the matrix is ​​disposed on the crown, the matrix does not come into contact with the gingival tissue.

[0039] By adopting the above technical solution, the substrate does not come into contact with the gum tissue when placed on the crown, thus avoiding discomfort to the user.

[0040] Preferably, the color of the matrix includes at least one of red, orange, yellow, green, cyan, blue, purple, white, black, and colorless.

[0041] By adopting the above technical solution and using the above colors for the substrate, the overall aesthetic appeal can be improved.

[0042] In summary, this application includes at least one of the following beneficial technical effects: 1. The matrix is ​​equipped with a drug storage unit, which can release the drug to the crown or oral cavity, and play a role in the treatment and care of the crown and other parts. Attached Figure Description

[0043] Figure 1 This is a structural schematic diagram of Embodiment 1 of this application.

[0044] Figure 2 This is a structural schematic diagram of Embodiment 2 of this application.

[0045] Figure 3 This is a structural schematic diagram of Embodiment 3 of this application.

[0046] Figure 4 This is a schematic diagram of the structure of Embodiment 4 of this application.

[0047] Figure 5 This is a structural schematic diagram of Embodiment 5 of this application.

[0048] Figure 6 This is a structural schematic diagram of Embodiment Six of this application.

[0049] Figure 7 This is a structural schematic diagram of Embodiment Seven of this application.

[0050] Figure 8 This is a structural schematic diagram of Embodiment 8 of this application.

[0051] Figure 9 This is a structural schematic diagram of Embodiment Nine of this application.

[0052] Figure 10 This is a structural schematic diagram of Embodiment 10 of this application.

[0053] Figure 11 This is a schematic diagram of the structure of Embodiment Eleven of this application; Figure 12 This is a structural schematic diagram of Embodiment Twelve of this application.

[0054] Explanation of reference numerals in the attached drawings: 1. Substrate; 11. Connecting piece; 12. Slot; 13. Handheld rod; 14. Body; 15. Substrate; 2. Adhesive layer; 3. Drug storage unit; 31. Drug cavity; 312. Drug outlet; 313. Sealing sheet; 32. Adsorption element; 33. Self-volatile drug layer; 34. Carrier; 35. Cavity; 4. Drug; 5. Crown. Detailed Implementation

[0055] The following is in conjunction with the appendix Figure 1-12This application will be described in further detail.

[0056] Example 1: like Figure 1 As shown, the teeth whitening strip includes a substrate 1, which is made of a biodegradable material. Preferably, it is made of a biodegradable material that is elastic, wear-resistant, and safe and hygienic, such as biodegradable silicone, cotton, polyester, food materials, grains, soy protein, and edible cellulose, or composite materials made of any one or more of the above materials. The above materials can increase the softness and elasticity of the substrate 1.

[0057] The length of the base 1 can be designed to be greater than or equal to the length of one crown 5 for the corresponding crown 5, or it can be designed to be greater than or equal to the length of multiple crowns 5, so as to cover multiple crowns 5.

[0058] When the matrix 1 is placed on the crown 5, the matrix 1 does not come into contact with the gingiva, and the color of the matrix 1 includes at least one of red, orange, yellow, green, cyan, blue, purple, white, black, and colorless.

[0059] like Figure 1 As shown, an adhesive layer 2 capable of adhering to the crown 5 is provided on one side of the substrate 1.

[0060] The adhesive layer 2 can be made of starch-based materials.

[0061] In this embodiment, the adhesion layer 2 includes a hydrated mucosa disposed on the substrate 1. When the hydrated mucosa comes into contact with saliva or water, it can be activated and adhered to the tooth, fixing the substrate 1 to the crown 5.

[0062] Specifically, the hydrated mucosa comprises one or more water-soluble, orally acceptable polymers, such as those selected from hydrophilic cellulose ethers (e.g., carboxymethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose), polyvinyl acetate, carbomer (e.g., Carbopol 971P), polysaccharide gum (e.g., xanthan gum), modified edible starch, gelatin (e.g., animal or fish-based gelatin), crosslinked carboxyvinyl copolymers, crosslinked polyvinylpyrrolidone, polyethylene oxide (ak.a. Polyox), polyacrylic acid and polyacrylate, polyvinyl alcohol, alginate, casein, pullulan, and combinations thereof.

[0063] The adhesive layer 2 can also use food-grade or medical-grade adhesives, such as carrageenan, xanthan gum, guar gum, agar, gelatin, sodium alginate, locust bean gum, konjac gum, silicone adhesive layer, and composite adhesive layer; the composite adhesive layer can be made according to carboplatin, dextrin, and magnesium stearate.

[0064] like Figure 1 As shown, the substrate 1 is provided with a drug storage unit 3. When the substrate 1 adheres to the crown 5, the drug storage unit 3 can release the drug 4 to the crown 5 and other parts.

[0065] In this embodiment, the drug storage unit 3 includes a drug cavity 31 disposed on the substrate 1, the drug cavity 31 is filled with drug 4, and the substrate 1 can be broken under the biting force of the teeth.

[0066] In this embodiment, the substrate 1 is flat, and the medicated cavity 31 is located at the center of the tooth crown 5 corresponding to the substrate 1.

[0067] Preferably, the substrate 1 includes a body 14 and a substrate 15, with the medicated cavity 31 located on the body 14. The substrate 15 is connected to the body 14 and covers the medicated cavity 31. The connection between the substrate 15 and the body 14 can be achieved through the following methods: adhesive bonding, solvent bonding (referring to the solvent dissolving the surfaces of the body 14 and the substrate 15 to mix the materials between the surfaces, and forming a joint after the solvent evaporates), hot wire welding (using a wire to transfer heat between the surfaces of the body 14 and the substrate 15 to melt the surfaces, and applying a certain pressure to connect them together), hot melt method (heating the body 14 and the cover 15 to their melting point using a hot melt machine, and then pressing them together), and sewing method (sewing the edges of the body 14 and the substrate 15 together to form an integrated silicone product).

[0068] Preferably, the substrate 1 has a drug outlet 312 that communicates with the drug cavity 31, allowing the drug in the drug cavity 31 to flow out slowly from the drug outlet 312. Therefore, the size of the drug outlet 312 should not be too large.

[0069] As a further preferred embodiment, a sealing sheet 313 is provided at the drug outlet 312 to seal the drug outlet 312, and the strength of the sealing sheet 313 is less than the strength of the substrate 1. In this case, the size of the drug outlet 312 is not limited. When the substrate 1 is subjected to force, the sealing sheet 313 breaks before the substrate 1, and the drug flows out from the drug outlet 312.

[0070] In this embodiment, the drug outlet 312 and the adhesion layer 2 are located on the same side of the substrate 1.

[0071] When the substrate 1 adheres to the crown 5, the drug outlet 312 is aligned with the crown 5. After the substrate 1 is subjected to force, since the strength of the substrate 1 is greater than the strength of the sealing strip 313, the sealing strip 313 will break preferentially under the pressure of the drug 4, allowing the drug 4 to flow out from the drug outlet 312.

[0072] Preferably, the drug 4 that the drug storage unit 3 can release includes at least one of the following: Liquid dosage forms, such as aromatic aqueous solutions, solutions, injections, mixtures, and lotions; Oral sustained-release formulations; Solid dosage forms of medicines: tablets, capsules, pills, powders, and granules, etc.; Semi-solid dosage forms of pharmaceuticals: such as ointments, pastes, extracts, etc.; Gaseous formulations, such as aerosols and sprays.

[0073] The working principle of this embodiment is as follows: the dental strip is attached to the crown 5 through the adhesive layer 2. When the teeth bite, the base 1 can break, allowing the drug 4 to flow out from the drug outlet 312 to treat the crown 5 and other parts.

[0074] Example 2: like Figure 2 As shown, this embodiment is largely the same as embodiment one, except that in this embodiment, the drug outlet 312 is provided on the side and upper surface of the substrate 1. When the substrate 1 is engaged, the drug outlet 312 can release the drug 4.

[0075] Example 3: like Figure 3 As shown, this embodiment is largely the same as embodiment two, except that in this embodiment, both sides of the base 1 are raised to form snap-fit ​​pieces 11, and a slot 12 that can be snapped onto the crown 5 is formed between the two snap-fit ​​pieces 11.

[0076] The slot 12 can be attached to a single crown 5 or to an entire row of teeth, and the clip 11 does not come into contact with the gum tissue.

[0077] In this embodiment, no adhesive layer is required. Of course, as another option, an adhesive layer can be added to improve the connection stability.

[0078] Example 4: like Figure 4 As shown, this embodiment is largely the same as embodiment one, except that in this embodiment, the base 1 is connected to a hand-held rod 13, and when the base 1 is placed on the crown 5, the hand-held rod 13 extends to the outside of the oral cavity.

[0079] The handheld stick 13 and the base 1 can be connected in one piece or by means of adhesive.

[0080] Example 5: like Figure 5 As shown, this embodiment is largely the same as Embodiment 1, except that in this embodiment, the drug storage unit 3 includes an absorbent 32 capable of being soaked in the drug solution, and the absorbent 32 is disposed on the substrate 1. The absorbent 32 can be made of cotton wool or sponge, etc. In this embodiment, the absorbent 32 and the adhesive layer 2 are located on the same side of the dental veneer. As another option, the absorbent 32 can also be disposed on the side of the substrate 1 opposite to the adhesive layer 2.

[0081] When the base 1 is attached to the crown 5, the cotton wool is squeezed when the tooth strip is bitten, which squeezes out the medicine in the cotton wool to treat and care for the crown 5 and other areas.

[0082] Example 6: like Figure 6 As shown, this embodiment is largely the same as embodiment one, except that in this embodiment, the drug storage unit 3 includes a self-volatile drug layer 33 sprayed on the substrate 1. In this embodiment, the self-volatile drug layer 33 and the adhesion layer 2 are located on the same side of the dental strip. Alternatively, the self-volatile drug layer 33 can also be disposed on the side of the substrate 1 opposite to the adhesion layer 2.

[0083] After the matrix 1 adheres to the crown 5, the self-volatile drug layer 33 slowly releases the drug 4 to treat and care for the crown 5 and other areas.

[0084] Example 7: like Figure 7 As shown, this embodiment is largely the same as embodiment one, except that in this embodiment, the drug storage unit 3 includes a carrier 34, one side of which is fixed to the substrate 1. The carrier 34 and the substrate 1 can be fixed by means of pasting, sewing, etc. The drug storage unit 3 includes a drug 4 sprayed on the other side of the carrier 34.

[0085] First, the drug 4 is sprayed onto the carrier 34, and then the carrier 34 is fixed onto the base 1. When the base 1 is adhered to the crown 5, it can provide treatment and care for the crown 5 or the oral cavity.

[0086] Example 8: like Figure 8 As shown, this embodiment is largely the same as Embodiment 1, except that in this embodiment, the substrate 1 has several pieces, and a cavity 35 is formed between two adjacent substrates 1. The cavity 35 is the drug storage unit 3, and the cavity 35 is filled with drug 4. When biting, the substrate 1 breaks, and the drug 4 in the cavity 35 can be released.

[0087] Example 9: like Figure 9 As shown, this embodiment is largely the same as embodiment one, except that in this embodiment, when the base 1 is placed on the crown 5, a drug cavity 31 is formed between the base 1 and the crown 5, and the drug cavity 31 is filled with drug 4, and the drug cavity 31 constitutes a drug storage unit 3.

[0088] When using, place the drug 4 on the crown 5, and then attach or hold the base 1 to the crown 5 to form a drug cavity 31 that encapsulates the drug 4. The base 1 does not touch the crown 5, and the drug 5 is released slowly.

[0089] Example 10: like Figure 10As shown, this embodiment is largely the same as embodiment one, except that in this embodiment, the drug storage unit 3 includes a drug 4 mixed and doped in the adhesive layer 2. The drug is directly mixed in the adhesive layer 2 of the substrate 1, and then the substrate 1 is attached to the crown 5 through the adhesive layer 2, and the drug 4 is slowly released.

[0090] Example 11: like Figure 11 As shown, in this embodiment, the drug delivery device includes an adhesive layer 2 that can adhere to the crown 5. The adhesive layer 2 is mixed with drug 4. The drug 4 is mixed with the adhesive layer 2 and directly applied to the crown 5 without additional film.

[0091] Example 12: like Figure 12 As shown, this embodiment is largely the same as embodiment one, except that in this embodiment, a drug placement area for placing the drug 4 is provided on one side of the substrate 1. The drug placement area is the drug storage unit 3. The adhesive layer 2 is located on the same side of the substrate 1 as the drug placement area, and the adhesive layer 2 is located on the periphery of the substrate 1. A drug outlet hole 312 is provided on the other side of the substrate 1, and the drug outlet hole 312 extends to the drug placement area.

[0092] The substrate 1 can be a thin film or similar structure, and the drug 4 can be placed in the drug placement area by spraying, adhesion, or other methods. The substrate 1 is attached to the crown 5, and the drug 4 in the drug storage unit 3 can flow into the oral cavity through the drug outlet 312 for treatment.

[0093] The above are all preferred embodiments of this application, and are not intended to limit the scope of protection of this application. Therefore, all equivalent changes made in accordance with the structure, shape and principle of this application should be covered within the scope of protection of this application.

Claims

1. An intraoral drug delivery device, characterized in that, The device includes a substrate (1) which can be disposed on a crown (5) and a drug storage unit (3) which can release a drug (4) when the substrate (1) is disposed on the crown (5); or, the drug release device includes an adhesive layer (2) which can adhere to the crown (5) and the adhesive layer (2) contains a drug (4).

2. The intraoral drug delivery device according to claim 1, characterized in that, One side of the substrate (1) is provided with an adhesive layer (2) that can adhere to the crown (5).

3. The intraoral drug delivery device according to claim 2, characterized in that, The drug storage unit (3) includes a drug (4) mixed and doped in the adhesive layer (2).

4. The intraoral drug delivery device according to claim 1, characterized in that, Both sides of the base (1) are raised to form snap-fit ​​pieces (11), and a slot (12) is formed between the two snap-fit ​​pieces (11) to snap onto the crown (5).

5. The intraoral drug delivery device according to claim 1, 2, 3, or 4, characterized in that, The base (1) is connected to a hand-held rod (13), and when the base (1) is placed on the crown (5), the hand-held rod (13) extends outside the oral cavity.

6. The intraoral drug delivery device according to claim 1, characterized in that, The drug storage unit (3) includes a drug cavity (31) disposed on the substrate (1), the drug cavity (31) being filled with drug (4), and the substrate (1) being capable of breaking under the biting force of teeth; or the drug storage unit (3) includes a drug cavity (31) disposed on the substrate (1), and the substrate (1) having a drug outlet hole (312) communicating with the drug cavity (31).

7. The intraoral drug delivery device according to claim 1, 2, 3, or 4, characterized in that, When the substrate (1) is placed on the crown (5), a drug cavity (31) is formed between the substrate (1) and the crown (5), and the drug cavity (31) constitutes a drug storage unit (3); or the drug storage unit (3) includes an absorbent (32) capable of being impregnated with drug solution, and the absorbent (32) is placed on the substrate (1); or the drug storage unit (3) includes a self-volatile drug layer (33) sprayed on the substrate (1); or the drug storage unit (3) includes a carrier (34), one side of the carrier (34) is fixed on the substrate (1), and the other side of the carrier (34) is sprayed with drug (4); or the substrate (1) has several pieces, and a cavity (35) is formed between two adjacent substrates (1), and the cavity (35) is the drug storage unit (3), and the cavity (35) is filled with drug (4).

8. The intraoral drug delivery device according to claim 2, characterized in that, A drug placement area for placing drugs (4) is provided on one side of the substrate (1), which is a drug storage unit (3). The adhesive layer (2) is located on the same side of the substrate (1) as the drug placement area, and the adhesive layer (2) is located on the periphery of the substrate (1). A drug outlet hole (312) is provided on the other side of the substrate (1), and the drug outlet hole (312) extends to the drug placement area.

9. The intraoral drug delivery device according to claim 1, characterized in that, The drug storage unit (3) can release drugs (4) including at least one of liquid dosage form, solid dosage form, semi-solid dosage form and gas dosage form; the matrix (1) is made of a biodegradable material and the adhesive layer (2) is made of starch-based material.

10. The intraoral drug delivery device according to claim 1, characterized in that, When the substrate (1) is placed on the crown (5), the substrate (1) does not come into contact with the gingival tissue.

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