An anti-inflammatory and acne-removing composition for treating acne-prone and sensitive skin, its preparation method, and its application.

Abstract

This invention relates to the field of daily chemical formulations, and more particularly to an anti-inflammatory and acne-removing composition for treating acne-prone skin, its preparation method, and its application. The composition comprises the following components by weight percentage: 0.00001%~0.5% cationic antibacterial agent, 0.005%~7.5% plant extracts, and 92%~99.8% excipients; the plant extracts include Phellodendron bark extract and White willow bark extract; wherein the weight ratio of the Phellodendron bark extract to the White willow bark extract is 1:(1.5~5). This invention has good acne-removing and anti-inflammatory effects, effectively regulating sensitive skin and inhibiting acne recurrence.

Description

Technical Field

[0001] This invention relates to the field of daily chemical formulations, and in particular to an anti-inflammatory and acne-removing composition for treating acne-prone skin, its preparation method, and its application. Background Technology

[0002] With the fast pace of modern life and increasing environmental pollution, skin problems have become a growing concern for consumers, especially acne, inflammation, bacterial infections, and sensitive skin, which significantly impact people's quality of life and mental well-being. While traditional chemically synthesized skincare products can alleviate these symptoms to some extent, their potential side effects and irritation often deter consumers.

[0003] Natural plants are widely used in the skincare field due to their unique bioactivity and gentleness. Plant extracts are usually rich in a variety of active ingredients, such as alkaloids, flavonoids, and polyphenols. These ingredients perform well in inhibiting bacterial growth, reducing inflammatory responses, and promoting skin repair.

[0004] Among the acne-removing and anti-inflammatory products commonly available on the market, the most frequently used plant extract is Phellodendron bark extract. This extract contains various alkaloids, possessing antibacterial, anti-infective, anti-inflammatory, analgesic, heat-clearing, dampness-drying, and antioxidant properties. However, while Phellodendron bark extract alone can inhibit Propionibacterium acnes and reduce inflammation through alkaloids such as berberine, it lacks direct intervention in the core aspects of acne formation: abnormal follicular keratosis and excessive sebum secretion. Although it can quickly remove acne, sensitive skin is prone to recurring inflammation and acne breakouts, accelerating skin aging. Summary of the Invention

[0005] The purpose of this invention is to overcome the shortcomings of the prior art. This invention provides an anti-inflammatory and acne-removing composition for conditioning acne-prone skin, its preparation method, and its application. It has good acne-removing and anti-inflammatory effects, can effectively regulate sensitive skin, and inhibit acne recurrence.

[0006] To address the above problems, this invention proposes an anti-inflammatory and acne-removing composition for treating acne-prone and sensitive skin, comprising the following components by weight percentage: Cationic antibacterial agent 0.00001%~0.5%, plant extract 0.006%~7.5%, excipients 92%~99.8%; The plant extracts include Amur cork tree bark extract and white willow bark extract; wherein the weight ratio of the Amur cork tree bark extract and white willow bark extract is 1:(1.5~5).

[0007] As an improvement to the above technical solution, the plant extract is a plant extract nanomaterial obtained by loading glycyrrhizic acid self-assembled nanomicelles, and the particle size of the plant extract nanomaterial is 130nm~180nm.

[0008] As an improvement to the above technical solution, the PDI of the plant extract nanomaterial is 0.5~0.6, and the Zeta potential is -18.9mV~-20.1mV.

[0009] As an improvement to the above technical solution, the preparation method of the plant extract nanomaterial includes the following steps: (1) The bark extract of Phellodendron bark and the bark extract of Salix babylonica were weighed and mixed in a weight ratio of 1:(1.5~5), and 100~200 parts by volume of anhydrous ethanol were added to prepare a loading solution. A certain amount of glycyrrhizic acid was weighed and dissolved in deionized water to prepare a glycyrrhizic acid solution. (2) The solution to be loaded is added dropwise to the glycyrrhizic acid solution at a dropping rate of 0.1 ml / min to 0.3 ml / min and stirred in a sealed container. Then, it is subjected to ultrasonic treatment under ice bath conditions. After ultrasonic treatment, the plant extract nanomaterial is obtained by microporous membrane filtration.

[0010] As an improvement to the above technical solution, in step (1), the concentration of the glycyrrhizic acid solution is 1.3 mg / ml to 1.8 mg / ml, and the volume ratio of the loading solution to the glycyrrhizic acid solution is 1:(8.5~12).

[0011] As an improvement to the above technical solution, in step (2), the sealing stirring time is 2h~3.5h, the ultrasonic treatment time is 15min~30min, the ultrasonic treatment power is 180~230W, the ultrasonic treatment maintains a working interval of 2s on / 1s off, and the pore size of the microporous filter is 0.5μm~1.2μm.

[0012] As an improvement to the above technical solution, the excipients comprise the following components in parts by weight: 0.1-1 part solubilizer 5-15 parts moisturizer Preservative 0.1-1.5 parts The solubilizer is one or more of PEG-40 hydrogenated castor oil, propylene glycol, polysorbate-20, and ethylene glycol salicylate. The moisturizing agent includes one or more of glycerin, butylene glycol, allantoin, trehalose, and betaine; The preservatives include one or more of p-hydroxyacetophenone, phenoxyethanol, octanoyl hydroxamic acid, 1,2-pentanediol, and 1,2-hexanediol; The cationic antibacterial agent includes one or more of quaternary ammonium salt-73, hexamididine di(hydroxyethyl sulfonic acid) salt, and chlorhexidine gluconate.

[0013] Accordingly, the present invention also provides a method for preparing an anti-inflammatory and acne-removing composition for treating acne-prone and sensitive skin, comprising the following steps: Add 0.006%~7.5% of plant extract, cationic antibacterial agent, and excipients to the reaction vessel according to the weight ratio, mix and stir evenly to obtain the final product.

[0014] Accordingly, the present invention also provides the application of an anti-inflammatory and acne-removing composition for conditioning acne-prone skin in cosmetics.

[0015] As an improvement to the above technical solution, the cosmetic is a toner, facial cleanser, shower gel, lotion, serum, skin care oil, essential oil, cream, spray, gel, mask, or freeze-dried powder.

[0016] The implementation of this invention has the following beneficial effects: This invention provides an anti-inflammatory and acne-reducing composition for acne-prone skin, comprising plant extracts including Phellodendron bark extract and white willow bark extract in a weight ratio of 1:(2.5~5). First, a cationic antibacterial agent works to disrupt bacterial cell membranes, rapidly killing Propionibacterium acnes, the acne-causing bacteria. The Phellodendron bark extract contains active ingredients such as berberine, synergistically enhancing the antibacterial effect. Second, both Phellodendron bark extract and white willow bark extract possess potent anti-inflammatory properties. White willow bark extract provides natural salicin, which inhibits the release of inflammatory factors, quickly reducing stinging sensation and effectively reducing swelling. Finally, the specific ratio of Phellodendron bark extract and white willow bark extract dissolves dead skin cells and oil in a slow-release manner, unclogging hair follicles while ensuring gentleness and reducing the risk of irritation to sensitive skin from traditional acidic ingredients. Attached Figure Description

[0017] Figure 1 This is a test result image of acne removal in Embodiment 1 of the present invention. Detailed Implementation

[0018] To make the objectives, technical solutions, and advantages of the present invention clearer, the present invention will be further described in detail below with reference to the accompanying drawings.

[0019] This invention provides an anti-inflammatory and acne-removing composition for treating acne-prone and sensitive skin, comprising the following components by weight percentage: Cationic antibacterial agent 0.00001%~0.5%, plant extract 0.006%~7.5%, excipients 92%~99.8%; The plant extracts include Amur cork tree bark extract and white willow bark extract; wherein the weight ratio of the Amur cork tree bark extract and white willow bark extract is 1:(1.5~5).

[0020] Phellodendron bark extract contains alkaloids such as berberine, which can disrupt bacterial DNA replication and significantly inhibit pathogenic bacteria such as Propionibacterium acnes and Staphylococcus aureus. It has a direct relieving effect on redness and sores caused by skin infections and is clinically used in acne creams and topical anti-inflammatory preparations. By regulating sebaceous gland activity, it reduces excessive sebum secretion and improves the environment of oily skin. Its bitter and cold properties can clear damp-heat, relieving symptoms such as eczema and thick yellow leukorrhea caused by damp-heat. It accelerates the regeneration of damaged skin cells, reduces acne marks and scars, and aids in wound healing.

[0021] White willow bark extract contains active ingredients such as salicin, phenolic glycosides, and flavonoids, which quickly soothe the stinging sensation of sensitive skin with acne. Salicin is slowly released and converted into salicylic acid, dissolving pore oil and unclogging blockages, improving closed comedones and blackheads. It is gentler than synthetic salicylic acid, avoiding peeling and irritation to sensitive skin. It inhibits pathogenic bacteria such as Propionibacterium acnes and Staphylococcus aureus, reducing acne recurrence. Containing natural mucilage and cellulose, it enhances the stratum corneum's water-locking ability, maintaining skin hydration.

[0022] The weight ratio of Amur cork tree bark extract to white willow bark extract is 1:(1.5~5), providing dual-pathway anti-inflammatory effects and quickly relieving redness, swelling, and pain. Amur cork tree extract inhibits the protein kinase C pathway, reducing the release of inflammatory factors; white willow bark extract blocks cyclooxygenase activity, reducing prostaglandin production. It gently unclogs pores, reducing the risk of irritation for sensitive skin. White willow bark extract provides sustained-release salicylic acid, dissolving oil more efficiently than the salicylic acid in other products, with significantly reduced irritation; the mucilage component of Amur cork tree extract forms a protective film, reducing barrier damage during exfoliation. It synergistically inhibits bacteria and controls oil, reducing acne recurrence. Amur cork tree extract directly inhibits the activity of Propionibacterium acnes; white willow bark extract regulates sebaceous glands, significantly reducing sebum production. Examples of weight ratios of Amur cork tree bark extract to white willow bark extract include 1:2.5, 1:2.7, 1:3.2, 1:3.7, 1:4.5, and 1:5, but are not limited to these. If the proportion of white willow bark extract is less than 1.5, the anti-inflammatory pathway is not adequately covered, and COX enzyme activity cannot be effectively blocked, resulting in prolonged redness and swelling reduction time and an increased risk of acne scar residue. If the amount of phellodendron bark extract is too high, and its ratio with white willow bark extract is close to 1:1, excessive alkaloids stimulate keratinocytes, leading to redness, peeling, and delayed barrier repair.

[0023] Traditional formulas containing Phellodendron amurense extract and white willow bark extract have poor water solubility, making it difficult for them to penetrate deep into hair follicles, resulting in poor skin absorption. Free salicin and high concentrations of berberine can easily cause peeling and stinging, and their action on acne-causing bacteria is relatively short, leading to recurring acne-prone and sensitive skin.

[0024] Preferably, the plant extract is a plant extract nanomaterial obtained by loading glycyrrhizic acid self-assembled nanomicelles, and the particle size of the plant extract nanomaterial is 130nm~180nm. Exemplary particle sizes are 130nm, 140nm, 150nm, 160nm, and 170nm, but are not limited thereto.

[0025] Glycyrrhizic acid micelles feature a hydrophobic core that efficiently encapsulates lipid-soluble active ingredients, while a hydrophilic shell enhances transdermal absorption, targeting deep within the hair follicle to target acne lesions and significantly improving transdermal efficiency. With particle sizes controlled between 130nm and 180nm, they precisely match the hair follicle opening, achieving highly efficient drug accumulation and effectively improving bacterial inhibition rates. Glycyrrhizic acid self-assembled nanomicelles release drugs within the inflammatory microenvironment, avoiding sudden release that could irritate sensitive skin. Glycyrrhizic acid promotes filaggrin synthesis, enhancing stratum corneum cohesion; the micelle phospholipid layer mimics cell membrane structure, filling lipid gaps and reducing transepidermal water loss.

[0026] More preferably, the PDI of the plant extract nanomaterial is 0.5~0.6, and the Zeta potential is -18.9mV~-20.1mV. A PDI of 0.5~0.6 provides moderate particle dispersibility, avoiding precipitation or stratification due to excessive aggregation and ensuring uniform release of active ingredients in the formulation. A Zeta potential of -18.9~-20.1mV provides moderate electrostatic repulsion, preventing particle collision and aggregation and maintaining the integrity of the micelle structure. The negatively charged surface enhances interaction with the positively charged stratum corneum of the skin, promoting the penetration of the nanocarrier into the hair follicle. The PDI (0.5~0.6) balances particle size uniformity and drug loading, ensuring efficient enrichment of 130~180nm particles in acne lesions.

[0027] More preferably, the preparation method of the plant extract nanomaterial includes the following steps: (1) The bark extract of Phellodendron bark and the bark extract of Salix babylonica were weighed and mixed in a weight ratio of 1:(1.5~5), and 100~200 parts by volume of anhydrous ethanol were added to prepare a loading solution. A certain amount of glycyrrhizic acid was weighed and dissolved in deionized water to prepare a glycyrrhizic acid solution. Specifically, the concentration of the glycyrrhizic acid solution is 1.3 mg / ml to 1.8 mg / ml, and the volume ratio of the loading solution to the glycyrrhizic acid solution is 1:(8.5~12). Examples of glycyrrhizic acid solution concentrations are 1.3 mg / ml, 1.4 mg / ml, 1.5 mg / ml, 1.6 mg / ml, 1.7 mg / ml, and 1.8 mg / ml, but are not limited to these. A concentration of 1.3 mg / ml to 1.8 mg / ml reaches the critical micelle concentration for glycyrrhizic acid self-assembly, ensuring the formation of a complete micelle structure and avoiding micelle disintegration or drug loading failure due to insufficient concentration. This avoids the risk of pseudoaldosteronism caused by high concentrations of glycyrrhizic acid, while also preventing excessive micelle accumulation leading to particle sizes greater than 180 nm, which could clog pores.

[0028] Examples of glycyrrhizic acid solution volume ratios are 1:8.5, 1:9, 1:10, and 1:12, but are not limited to these. A volume ratio ≥1:8.5 ensures sufficient aqueous phase to maintain the integrity of the micelle's hydrophilic shell, avoids excessive ethanol damaging the micelle structure, and ensures stable particle size within 130 nm to 180 nm. A volume ratio ≤1:12 prevents excessive dilution of the active ingredient by the aqueous phase, leading to insufficient drug loading.

[0029] (2) The solution to be loaded is added dropwise to the glycyrrhizic acid solution at a dropping rate of 0.1 ml / min to 0.3 ml / min and stirred in a sealed manner. Then, it is subjected to ultrasonic treatment under ice bath conditions. After ultrasonic treatment, the plant extract nanomaterial is obtained by microporous membrane filtration. Specifically, the sealing and stirring time is 2h~3.5h, the ultrasonic treatment time is 15min~30min, the ultrasonic treatment power is 180~230W, the ultrasonic treatment is maintained at a working interval of 2s on / 1s off, and the pore size of the microporous filter is 0.5μm~1.2μm.

[0030] Examples of the dropping rates for the loading solution are 0.1 ml / min, 0.2 ml / min, 0.25 ml / min, and 0.3 ml / min, but not limited to these. Controlling the dropping rate prevents the instantaneous concentration of the loading solution from being too high, which could damage the hydrophilic shell of the glycyrrhizic acid micelles, prevents a sudden increase in particle size, and ensures that the active ingredient is gradually embedded into the hydrophobic core of the micelles.

[0031] Examples of sealed stirring times include 2 hours, 2.5 hours, 3 hours, and 3.5 hours, but are not limited to these. These sealed stirring times ensure that berberine and salicin fully diffuse into the micelle core. Furthermore, the sealed environment reduces ethanol evaporation, maintains a stable solvent ratio, and prevents the release of active components due to a decrease in ethanol concentration.

[0032] Examples of pore sizes for microfiltration are 0.5μm, 0.6μm, 0.8μm, 0.9μm, 1.1μm, and 1.2μm, but are not limited thereto.

[0033] It should be noted that the above correspondence between parts by weight and parts by volume is in g / ml.

[0034] Preferably, the excipients comprise the following components in parts by weight: 0.1-1 part solubilizer 5-15 parts moisturizer Preservative 0.1-1.5 parts The solubilizer is one or more of PEG-40 hydrogenated castor oil, propylene glycol, polysorbate-20, and ethylene glycol salicylate. The moisturizing agent includes one or more of glycerin, butylene glycol, allantoin, trehalose, and betaine; The preservatives include one or more of p-hydroxyacetophenone, phenoxyethanol, octanoyl hydroxamic acid, 1,2-pentanediol, and 1,2-hexanediol; The cationic antibacterial agent includes one or more of quaternary ammonium salt-73, hexamididine di(hydroxyethyl sulfonic acid) salt, and chlorhexidine gluconate.

[0035] Accordingly, the present invention also provides a method for preparing an anti-inflammatory and acne-removing composition for acne-prone and sensitive skin, comprising the following steps: Add 0.006%~7.5% of plant extract, cationic antibacterial agent, and excipients to the reaction vessel according to the weight ratio, mix and stir evenly to obtain the final product.

[0036] Accordingly, the present invention also provides the application of an anti-inflammatory and acne-removing composition for conditioning acne-prone skin in cosmetics.

[0037] Preferably, the cosmetic is a toner, lotion, serum, cream, ointment, mask, gel, or freeze-dried powder.

[0038] The present invention will be further described below with reference to specific embodiments.

[0039] Example 1 An anti-inflammatory and acne-removing composition for treating acne-prone and sensitive skin, characterized by comprising the following components by weight percentage: The composition includes 0.25% cationic antibacterial agent, 5% plant extract, and 94.75% excipients. The plant extracts include Amur cork tree bark extract and white willow bark extract; wherein the weight ratio of the Amur cork tree bark extract and white willow bark extract is 1:3.5. The excipients comprise the following components in parts by weight: 0.5 parts of solubilizer 10 parts moisturizer 1.5 parts preservative The solubilizer is polysorbate-20; The humectant is glycerin; The preservative is p-hydroxyacetophenone; The cationic antibacterial agent is chlorhexidine gluconate.

[0040] Example 2 The difference between this embodiment and Embodiment 1 is that: The plant extract is a plant extract nanomaterial obtained by loading glycyrrhizic acid self-assembled nanomicelles, and the particle size of the plant extract nanomaterial is 130 nm to 180 nm. The PDI of the plant extract nanomaterial is 0.5 to 0.6, and the Zeta potential is -18.9 mV to -20.1 mV. The preparation method of the plant extract nanomaterials includes the following steps: (1) The bark extract of Phellodendron bark and the bark extract of Salix babylonica were weighed and mixed in a weight ratio of 1:3.5, and 150 parts by volume of anhydrous ethanol were added to prepare a loading solution. A certain amount of glycyrrhizic acid was weighed and dissolved in deionized water to prepare a glycyrrhizic acid solution with a concentration of 1.5 mg / ml. The volume ratio of the loading solution to the glycyrrhizic acid solution was 1:10. (2) The solution to be loaded was added dropwise to the glycyrrhizic acid solution at a rate of 0.15 ml / min and stirred in a sealed container for 2.5 h. Then, it was subjected to ultrasonic treatment for 25 min under ice bath conditions. The ultrasonic treatment power was 200 W and the ultrasonic treatment was maintained at a working interval of 2 s on / 1 s off. After ultrasonic treatment, a microporous filter membrane with a pore size of 0.8 μm was used to filter and obtain the plant extract nanomaterial.

[0041] Example 3 The difference between this embodiment and Embodiment 1 is that: The weight ratio of Amur cork tree bark extract to white willow bark extract was 1:2.5.

[0042] Example 4 The difference between this embodiment and Embodiment 1 is that: The weight ratio of Amur cork tree bark extract to white willow bark extract is 1:5.

[0043] Comparative Example 1 The difference between this embodiment and Embodiment 1 is that: The plant extract contains only Amur cork tree bark extract.

[0044] Comparative Example 2 The difference between this embodiment and Embodiment 1 is that: The plant extract contains only white willow bark extract.

[0045] Comparative Example 3 The difference between this embodiment and Embodiment 1 is that: The weight ratio of the Amur cork tree bark extract to the white willow bark extract is 1:1.

[0046] After preparing anti-inflammatory and acne-removing compositions for acne-prone skin using Examples 1-4 and Comparative Examples 1-3, and testing them on test cases, the size of acne in the test cases was determined using facial image analysis (VISIA-CR) and the skin red pigment probe (Mexameter MX18). The experimental results are as follows.

[0047]

[0048] The anti-inflammatory and acne-removing compositions for acne-prone skin prepared in Examples 1 and 2 were compared. The efficacy of the compositions in the two examples was tested by observing the use of Examples 1 and 2 by 30 subjects with obvious acne in each group using VISIA-CR images. The test results are as follows.

[0049] Results of Example 1:

[0050] See Figure 1 As shown.

[0051] Significant effect: Acne is significantly reduced compared to 28 days ago, and redness is significantly reduced. Effective: Acne has slightly decreased compared to 28 days ago, and redness has decreased. Ineffective: No significant changes in acne or pigmentation. Results of Example 2:

[0052] Significant effect: Acne is significantly reduced compared to 28 days ago, and redness is significantly reduced. Effective: Acne has slightly decreased compared to 28 days ago, and redness has decreased. Ineffective: No significant changes in acne or pigmentation. This invention provides an anti-inflammatory and acne-reducing composition for acne-prone skin, comprising plant extracts including Phellodendron bark extract and white willow bark extract in a weight ratio of 1:(1.5~5). First, a cationic antibacterial agent works to disrupt bacterial cell membranes, rapidly killing Propionibacterium acnes, the acne-causing bacteria. The Phellodendron bark extract contains active ingredients such as berberine, synergistically enhancing the antibacterial effect. Second, both Phellodendron bark extract and white willow bark extract possess potent anti-inflammatory properties. White willow bark extract provides natural salicin, which inhibits the release of inflammatory factors, quickly reducing stinging sensation and effectively reducing swelling. Finally, the specific ratio of Phellodendron bark extract and white willow bark extract dissolves dead skin cells and oil in a slow-release manner, unclogging hair follicles while ensuring gentleness and reducing the risk of irritation to sensitive skin from traditional acidic ingredients.

[0053] The above description represents the preferred embodiments of the present invention. It should be noted that those skilled in the art can make various improvements and modifications without departing from the principles of the present invention, and these improvements and modifications are also considered to be within the scope of protection of the present invention.

Claims

1. An anti-inflammatory and acne-removing composition for treating acne-prone and sensitive skin, characterized in that, Includes the following components by weight percentage: Cationic antibacterial agent 0.00001%~0.5%, plant extract 0.006%~7.5%, excipients 92%~99.8%; The plant extracts include Amur cork tree bark extract and white willow bark extract; wherein the weight ratio of the Amur cork tree bark extract and white willow bark extract is 1:(1.5~5).

2. The anti-inflammatory and acne-removing composition for treating acne-prone and sensitive skin as described in claim 1, characterized in that, The plant extract is a plant extract nanomaterial obtained by loading glycyrrhizic acid self-assembled nanomicelles, and the particle size of the plant extract nanomaterial is 130nm~180nm.

3. The anti-inflammatory and acne-removing composition for treating acne-prone and sensitive skin as described in claim 2, characterized in that, The plant extract nanomaterial has a PDI of 0.5~0.6 and a Zeta potential of -18.9mV~-20.1mV.

4. The anti-inflammatory and acne-removing composition for treating acne-prone and sensitive skin as described in claim 2 or 3, characterized in that, The preparation method of the plant extract nanomaterials includes the following steps: (1) The bark extract of Phellodendron bark and the bark extract of Salix babylonica were weighed and mixed in a weight ratio of 1:(1.5~5), and 100~200 parts by volume of anhydrous ethanol were added to prepare a loading solution. A certain amount of glycyrrhizic acid was weighed and dissolved in deionized water to prepare a glycyrrhizic acid solution. (2) The solution to be loaded is added dropwise to the glycyrrhizic acid solution at a dropping rate of 0.1 ml / min to 0.3 ml / min and stirred in a sealed container. Then, it is subjected to ultrasonic treatment under ice bath conditions. After ultrasonic treatment, the plant extract nanomaterial is obtained by microporous membrane filtration.

5. The anti-inflammatory and acne-removing composition for treating acne-prone and sensitive skin as described in claim 4, characterized in that, In step (1), the concentration of the glycyrrhizic acid solution is 1.3 mg / ml to 1.8 mg / ml, and the volume ratio of the loading solution to the glycyrrhizic acid solution is 1:(8.5~12).

6. The anti-inflammatory and acne-removing composition for treating acne-prone and sensitive skin as described in claim 4, characterized in that, In step (2), the sealing and stirring time is 2h~3.5h, the ultrasonic treatment time is 15min~30min, the ultrasonic treatment power is 180~230W, the ultrasonic treatment is maintained at a working interval of 2s on / 1s off, and the pore size of the microporous filter is 0.5μm~1.2μm.

7. The anti-inflammatory and acne-removing composition for treating acne-prone and sensitive skin as described in claim 1, characterized in that, The excipients comprise the following components in parts by weight: 0.1-1 part solubilizer 5-15 parts moisturizer Preservative 0.1-1.5 parts The solubilizer is one or more of PEG-40 hydrogenated castor oil, propylene glycol, polysorbate-20, and ethylene glycol salicylate. The moisturizing agent includes one or more of glycerin, butylene glycol, allantoin, trehalose, and betaine; The preservatives include one or more of p-hydroxyacetophenone, phenoxyethanol, octanoyl hydroxamic acid, 1,2-pentanediol, and 1,2-hexanediol; The cationic antibacterial agent includes one or more of quaternary ammonium salt-73, hexamididine di(hydroxyethyl sulfonic acid) salt, and chlorhexidine gluconate.

8. A method for preparing an anti-inflammatory and acne-removing composition for conditioning acne-prone skin as described in any one of claims 1 to 7, characterized in that, Includes the following steps: Add 0.006%~7.5% of plant extract, cationic antibacterial agent, and excipients to the reaction vessel according to the weight ratio, mix and stir evenly to obtain the final product.

9. The use of an anti-inflammatory and acne-removing composition for conditioning acne-prone skin as described in any one of claims 1 to 7 in cosmetics.

10. The application as described in claim 9, characterized in that, The cosmetics mentioned are toners, facial cleansers, shower gels, lotions, serums, skin care oils, essential oils, creams, sprays, gels, masks, or freeze-dried powders.

Images