A traditional Chinese medicine external nasal powder for dredging collaterals and unblocking orifices and a preparation method thereof

Abstract

This invention discloses a traditional Chinese medicine nasal inhalation powder for facial meridian clearing and nasal closure, and its preparation method. The powder is prepared from the following raw materials in parts by weight: 5-10 parts musk, 12-17 parts angelica dahurica, 15-20 parts peppermint, 7-12 parts black sedge, 12-17 parts pearl, 15-20 parts asarum, and 10-30 parts soapberry. This traditional Chinese medicine nasal inhalation powder and its preparation method for facial meridian clearing and nasal closure exhibit multi-target synergistic effects. The effects of this invention are remarkable. The formula is scientific, with the various herbs working together. Musk and Asarum are the principal herbs, which have a strong effect of opening the orifices, refreshing the mind, dispelling wind and cold. Angelica dahurica and Gleditsia sinensis are the assistant herbs, which dispel wind and dry dampness and open the nasal passages. Zaocys dhumnades dispels wind and unblocks the meridians. Peppermint is cooling and dispersing. Pearl detoxifies and promotes tissue regeneration. Together, they assist the principal and assistant herbs in their effects. This combination can not only quickly relieve facial muscle spasms and numbness, but also improve local microcirculation and promote the recovery of nerve function. Nasal administration is fast-acting and takes effect by utilizing the rich vascular network and olfactory nerve pathway of the nasal mucosa.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine technology, specifically to a topical nasal powder for facial meridian clearing and nasal osmosis and its preparation method. Background Technology

[0002] Western medicine treatments for facial paralysis often employ glucocorticoids, antiviral drugs, and neurotrophic drugs. While these have some efficacy, long-term use carries the risk of side effects. Traditional Chinese medicine therapies such as acupuncture and moxibustion are highly effective, but require skilled practitioners, and some patients find them difficult to tolerate due to pain or fear. Furthermore, oral Chinese herbal decoctions have a slow onset of action and limited bioavailability. Traditional Chinese medicine theory holds that facial paralysis is often caused by insufficient vital energy (Qi) and empty meridians, allowing wind-cold or wind-heat pathogens to invade the facial meridians, leading to Qi and blood stagnation and malnourishment of the tendons and vessels. The treatment principle focuses on "dispelling wind, unblocking meridians, promoting blood circulation, and stopping spasms." The nose is the orifice of the lungs and is closely connected to the meridians throughout the body. Administering medication through the nasal cavity utilizes the aromatic and penetrating properties of the drugs to quickly reach the convergence of Yang meridians, achieving the effect of "opening the orifices and relieving stagnation." However, currently, there are few nasal inhaled Chinese herbal preparations for facial paralysis on the market, and many of them suffer from problems such as limited efficacy, poor permeability, or excessive irritation. Summary of the Invention

[0003] The technical problem to be solved by the present invention is to overcome the existing defects and provide a traditional Chinese medicine nasal powder for facial relaxation and nasal passage opening, and its preparation method. It is convenient to use, has a rapid onset of action, and achieves facial relaxation and nasal passage opening through nasal inhalation, which can effectively solve the problems in the background art.

[0004] To achieve the above objectives, the present invention provides the following technical solution:

[0005] A traditional Chinese medicine nasal powder for facial massage to soothe the meridians and clear the orifices is prepared from the following raw materials in parts by weight: 5-10 parts musk, 12-17 parts angelica dahurica, 15-20 parts peppermint, 7-12 parts black sedge, 12-17 parts pearl, 15-20 parts asarum, and 10-30 parts soapberry.

[0006] Preferably, the traditional Chinese medicine nasal powder for facial nasal inhalation is prepared from the following preferred parts by weight of raw materials: 7-9 parts of musk, 14-16 parts of angelica dahurica, 16-18 parts of peppermint, 8-10 parts of black sedge, 13-15 parts of pearl, 16-18 parts of asarum, and 15-20 parts of soapberry.

[0007] Preferably, the particle size of each raw material in the powder is 100-300 mesh, wherein the particle size of pearl is 300-500 mesh.

[0008] The preparation method of the traditional Chinese medicine nasal powder for facial meridian clearing and nasal discharge includes the following steps:

[0009] Step 1: Grind the pearls separately into an extremely fine powder (300 mesh or finer).

[0010] Step 2: Dry the musk, angelica, black snake, and asarum, then mix and pulverize them, and pass them through a 100-200 mesh sieve.

[0011] Step 3: Grind the peppermint and tooth soap at low temperature and pass them through a 100-200 mesh sieve;

[0012] Step four: Mix the above components evenly using the equal-volume incremental addition method to obtain the traditional Chinese medicine external powder.

[0013] Compared with the prior art, the beneficial effects of the present invention are:

[0014] 1. Multi-target synergy, significant effect of clearing the meridians. The formula of this invention is scientific. The combination of various drugs, musk and asarum are the principal drugs, which have a strong effect of opening the orifices and refreshing the mind, dispelling wind and cold. Angelica dahurica and soapberry are the assistant drugs, which dispel wind and dry dampness and clear the nasal passages. Zaocys dhumnades dispel wind and clear the meridians. Peppermint is cool and dispersing. Pearl detoxifies and promotes tissue regeneration. Together, they assist the principal and assistant drugs. This combination can not only quickly relieve facial muscle spasms and numbness, but also improve local microcirculation and promote the recovery of nerve function.

[0015] 2. Nasal administration has a rapid onset of action. Utilizing the rich vascular network of the nasal mucosa and the olfactory nerve pathway, the drug can be directly absorbed into the blood or directly reach the relevant nuclei of the central nervous system. This avoids the first-pass effect and digestive juice destruction of oral drugs, resulting in high bioavailability, short onset time, and rapid achievement of the purpose of "opening the nasal passages".

[0016] 3. Particle size control ensures safety and comfort. Through a specific preparation process, the pearl is pulverized to 300-500 mesh, while the remaining medicines are controlled to 100-300 mesh, ensuring the fineness of the powder. This not only increases the specific surface area of ​​the medicine, which is beneficial for mucosal adsorption and absorption, but also avoids physical irritation and damage to the nasal mucosa caused by coarse particles, resulting in a gentle user experience. Attached Figure Description

[0017] Figure 1 This is a schematic diagram of the method flow of the present invention. Detailed Implementation

[0018] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0019] Please see Figure 1 The present invention provides a technical solution:

[0020] A traditional Chinese medicine nasal powder for facial massage to soothe the meridians and clear the orifices is prepared from the following raw materials in parts by weight: 5-10 parts musk, 12-17 parts angelica dahurica, 15-20 parts peppermint, 7-12 parts black sedge, 12-17 parts pearl, 15-20 parts asarum, and 10-30 parts soapberry.

[0021] This traditional Chinese medicine nasal powder for facial massage and nasal inhalation is prepared from the following preferred parts by weight: 7-9 parts musk, 14-16 parts angelica dahurica, 16-18 parts peppermint, 8-10 parts black sedge, 13-15 parts pearl, 16-18 parts asarum, and 15-20 parts soapberry.

[0022] The particle size of each raw material in the powder is 100-300 mesh, and the particle size of pearl is 300-500 mesh.

[0023] All raw materials used in the powder are of high quality and are cleaned and processed before use.

[0024] The preparation method of a traditional Chinese medicine nasal inhalation powder for facial pore clearing and meridian clearing includes the following steps:

[0025] Step 1: Grind the pearls separately into an extremely fine powder (300 mesh or finer).

[0026] Step 2: Dry the musk, angelica, black snake, and asarum, then mix and pulverize them, and pass them through a 100-200 mesh sieve.

[0027] Step 3: Grind the peppermint and tooth soap at low temperature and pass them through a 100-200 mesh sieve;

[0028] Step four: Mix the above components evenly using the equal-volume incremental addition method to obtain the traditional Chinese medicine external powder.

[0029] Example 1: Preparation of nasal powder

[0030] According to the preferred formula, weigh the following raw materials: 8g of musk, 15g of angelica dahurica, 17g of peppermint, 9g of black snake, 14g of pearl, 17g of asarum, and 18g of soapberry.

[0031] The preparation steps are as follows:

[0032] 1. Pearl processing: The pearls are individually pulverized using ball milling, passed through a 300-mesh sieve to obtain extremely fine powder, and sealed for later use.

[0033] 2. Ordinary pulverization: Mix musk, angelica, black snake, and asarum, dry at 60℃ for 2 hours, pulverize and pass through a 150-mesh sieve.

[0034] 3. Low-temperature pulverization: Pre-cool the peppermint and tooth soap at -10℃ for 1 hour, then pulverize them at low temperature and pass them through a 150-mesh sieve (to prevent the loss of volatile components).

[0035] 4. Mixing: Using the equal-volume incremental method, first mix the powders from steps 2 and 3 evenly, then package them to obtain the finished product.

[0036] Example 2: Clinical application efficacy verification (controlled experiment)

[0037] To verify the therapeutic effect of the nasal powder of the present invention, a clinical controlled trial was conducted.

[0038] Subjects: Sixty patients diagnosed with peripheral facial paralysis in outpatient clinics were selected, with a disease course of 7-30 days.

[0039] Grouping: The patients were randomly divided into an experimental group (30 cases) and a control group (30 cases).

[0040] Treatment methods:

[0041] Experimental group: The nasal powder prepared in Example 1 of this invention was inhaled once each in the morning, noon and evening (each inhalation dose was about 10-20mg). Routine basic care was also provided.

[0042] Control group: Only received routine acupuncture treatment, once every other day.

[0043] Both treatment courses lasted for 2 weeks.

[0044] Evaluation criteria: Based on the "Standards for Evaluation of the Severity and Efficacy of Facial Paralysis", observe the improvement of House-Brackmann (HB) grading and the recovery time of symptoms (forehead wrinkles, eye fissures, nasolabial folds, and corners of the mouth) before and after treatment.

[0045] Experimental results:

[0046] Group Number of examples Average score before treatment Average score after treatment Overall efficiency Facial soothing onset time Experimental group (this invention) 30 2.8±0.5 1.2±0.4 93.3% Relatively fast (average 3 minutes) Control group (acupuncture) 30 2.7±0.6 1.8±0.5 80.0% Slower (average 24 hours)

[0047] Results analysis:

[0048] a. Significant therapeutic effect: The total effective rate of the experimental group (93.3%) was significantly higher than that of the control group (80.0%), indicating that the nasal powder of the present invention combined with basic nursing care has significant advantages in promoting the recovery of facial paralysis.

[0049] b. Rapid onset of action: Patients report that after inhaling the powder of this invention, they can feel nasal patency and facial tightness relieved within about 3 minutes, which is consistent with the mechanism of nasal administration acting directly on the nerve pathway.

[0050] c. Safety: No obvious adverse reactions were observed in the experimental group. Only a few patients experienced brief sneezing (which is a normal physiological reflex), indicating that the topical powder has high safety and good compliance.

[0051] In summary, the present invention is effective, rapid, and safe in treating facial paralysis, and has good application prospects.

[0052] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A traditional Chinese medicine nasal inhalation powder for facial meridian clearing and orifice unblocking, characterized in that, It is prepared from the following raw materials in parts by weight: 5-10 parts musk, 12-17 parts angelica dahurica, 15-20 parts peppermint, 7-12 parts black shad, 12-17 parts pearl, 15-20 parts asarum, and 10-30 parts soapberry.

2. The traditional Chinese medicine nasal powder for facial meridian clearing and nasal discharge according to claim 1, characterized in that, It is prepared from the following preferred parts by weight of raw materials: 7-9 parts of musk, 14-16 parts of angelica dahurica, 16-18 parts of peppermint, 8-10 parts of black sedge, 13-15 parts of pearl, 16-18 parts of asarum, and 15-20 parts of soapberry.

3. The traditional Chinese medicine nasal powder for facial meridian clearing and orifice unblocking as described in claim 1, characterized in that, The particle size of each raw material in the powder is 100-300 mesh, and the particle size of pearl is 300-500 mesh.

4. A method for preparing a traditional Chinese medicine nasal inhalation powder for facial meridian clearing and orifice unblocking as described in any one of claims 1 to 3, characterized in that, Includes the following steps: Step 1: Grind the pearls separately into an extremely fine powder (300 mesh or finer). Step 2: Dry the musk, angelica, black snake, and asarum, then mix and pulverize them, and pass them through a 100-200 mesh sieve. Step 3: Grind the peppermint and tooth soap at low temperature and pass them through a 100-200 mesh sieve; Step four: Mix the above components evenly using the equal-volume incremental addition method to obtain the traditional Chinese medicine external powder.

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