A specific structural lipase inhibitor for activating atgl and preparation method and application thereof

By optimizing the grape leaf extraction process, a lipase inhibitor with a specific structure was prepared, which solved the problem of unclear structure of lipase inhibitors in the existing technology. It achieved the dual effect of lipase inhibition and ATGL activation, effectively regulating lipid metabolism and weight control, improving blood lipids and blood sugar, and is suitable for industrial application.

CN122124161APending Publication Date: 2026-06-02OCEAN UNIV OF CHINA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
OCEAN UNIV OF CHINA
Filing Date
2026-04-14
Publication Date
2026-06-02

AI Technical Summary

Technical Problem

Existing technologies lack grape leaf-derived lipase inhibitors with well-defined structures, precise proportions, clear mechanisms, and well-defined functional targets. They cannot simultaneously achieve lipase inhibition, ATGL activation, lipid metabolism regulation, and appetite hormone balance, and do not involve human testing effects.

Method used

By optimizing the extraction process, a lipase inhibitor with a specific structure was extracted from grape leaves. The extraction was carried out using an organic solvent such as a mixture of n-hexane and ethanol. Combined with ultrasonic treatment and rotary evaporation, flavonoids, coumarins and phenolic acid compounds were selectively enriched to form an inhibitor with dual effects of lipase inhibition and ATGL activation.

Benefits of technology

It significantly improves lipase inhibitory activity, achieving a dual effect of lipase inhibition and ATGL activation, regulating lipid metabolism, controlling weight, improving blood lipids and stabilizing blood sugar, with high safety and suitable for industrial application.

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Abstract

This invention belongs to the field of biomedical technology and discloses a specific structural lipase inhibitor that promotes ATGL activation, its preparation method, and its application. The inhibitor is derived from grape leaves. Through optimized extraction processes, the lipase inhibitory activity is significantly improved. The compound composition and structural ratio of the inhibitor are directionally enriched and clarified, resulting in a product with stable activity and controllable quality. Experiments have confirmed that the lipase inhibitor described in this application can simultaneously inhibit fat absorption and activate ATGL, forming a dual mechanism of action of "inhibiting absorption" and "inhibiting storage." It reduces TG, TC, LDL-C, LP, and FFA, upregulates HDL-C, stabilizes leptin, reduces ghrelin, and increases CCK and PYY, thereby effectively regulating lipid metabolism, controlling weight, improving blood lipids, and stabilizing blood sugar, with high safety.
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