A traditional Chinese medicine composition for treating osteoporosis and a preparation method and application thereof

Abstract

This invention relates to a traditional Chinese medicine composition for treating osteoporosis, its preparation method, and its application. The composition is prepared from the following herbs: Astragalus membranaceus, Dioscorea opposita, Citrus medica, Angelica sinensis, Citrus reticulata peel, Codonopsis pilosula, Eucommia ulmoides leaf, Ophiopogon japonicus, Cistanche deserticola, Ziziphus jujuba seed, Poria cocos, and Ganoderma lucidum. The beneficial effects of this invention are: this formula not only focuses on "bones" but also emphasizes the regulation of overall function. By regulating spleen and kidney function and improving qi and blood status, it achieves a comprehensive effect of strengthening bones, relieving pain, and improving physical strength, reflecting the advantages of traditional Chinese medicine's "prevention of disease" and holistic view; all raw materials are selected from the list of medicinal and edible homologous substances published by the National Health Commission, ensuring high safety and suitability for long-term consumption; the drugs used in this invention are inexpensive, reducing the economic burden on patients.

Description

Technical Field

[0001] This invention relates to the field of osteoporosis treatment technology, and in particular to a traditional Chinese medicine composition for treating osteoporosis, its preparation method, and its application. Background Technology

[0002] Osteoporosis (OP) is a systemic bone disease characterized by decreased bone mass, damage to bone microstructure, increased bone fragility, and susceptibility to fractures. With the aging population, its incidence is rising annually, becoming a serious public health problem. Modern medical treatments often employ calcium supplements, vitamin D, and bisphosphonates, which, while effective to some extent, can cause side effects such as gastrointestinal reactions, kidney damage, and osteonecrosis of the mandible with long-term use, and are also costly.

[0003] Traditional Chinese medicine (TCM) has unique advantages in preventing and treating osteoporosis, including holistic regulation, multi-target intervention, and relatively high safety. Currently, some TCM compound formulas are used to treat osteoporosis, but most prescriptions contain herbs that are not food or medicinal materials, requiring caution for long-term use, and are also costly. Summary of the Invention

[0004] The purpose of this invention is to provide a traditional Chinese medicine composition for treating osteoporosis, its preparation method, and its application, thereby solving the aforementioned problems existing in the prior art.

[0005] The technical solution of the present invention to solve the above-mentioned technical problems is as follows: A traditional Chinese medicine composition for treating osteoporosis, the composition being prepared from the following traditional Chinese medicines: Astragalus membranaceus, Dioscorea opposita, Citrus medica, Angelica sinensis, Citrus reticulata peel, Codonopsis pilosula, Eucommia ulmoides leaf, Ophiopogon japonicus, Cistanche deserticola, Ziziphus jujuba seed, Poria cocos, and Ganoderma lucidum.

[0006] The beneficial effects of this invention are: this formula not only focuses on "bones" but also emphasizes the regulation of overall function. By regulating the function of the spleen and kidneys and improving the state of qi and blood, it achieves a comprehensive effect of strengthening bones, relieving pain, and improving physical strength, reflecting the advantages of traditional Chinese medicine in "prevention of disease" and holistic view; the raw materials are all selected from the list of food and medicine homology published by the National Health Commission, which is highly safe and suitable for long-term consumption; the drugs used in this invention are inexpensive, reducing the economic burden on patients.

[0007] Based on the above technical solution, the present invention can be further improved as follows.

[0008] Furthermore, the traditional Chinese medicine composition is in the form of capsules, pills, tablets, or granules.

[0009] The further beneficial effects of adopting the above are: when formulated into capsules, pills, tablets, granules, or health foods, they have an easy-to-accept taste, are convenient to take, and have good patient compliance.

[0010] Another technical solution of the present invention is as follows: A method for preparing a traditional Chinese medicine composition for treating osteoporosis, comprising the following steps: Step 1: Grind the following ingredients, weighed according to their weight percentages, into coarse powder: Astragalus membranaceus, Dioscorea opposita, Citrus medica, Angelica sinensis, Citrus reticulata peel, Codonopsis pilosula, Eucommia ulmoides leaf, Ophiopogon japonicus, Cistanche deserticola, Ziziphus jujuba seed, Poria cocos, and Ganoderma lucidum Step 2: Weigh out the coarse powder from Step 1 according to the weight proportions, add water and boil several times. After boiling for a period of time, filter and concentrate to obtain the extract. Step 3: Add ethanol to the extract obtained in Step 2, stir well, let stand for a period of time, and then filter. Step 4: Recover the ethanol from the filtrate of Step 3, concentrate it to obtain an extract, and dry the extract to obtain a dry extract; Step 5: Crush the dry extract from Step 4 into powder, add excipients, and prepare capsules, pills, tablets, or granules.

[0011] It is easy to prepare, requires no complicated extraction, has low cost, and is easy to industrialize.

[0012] Another technical solution of this invention is as follows: Application of a traditional Chinese medicine composition for treating osteoporosis: applying the traditional Chinese medicine composition for treating osteoporosis to drugs or health foods for the prevention or treatment of osteoporosis. Attached Figure Description

[0013] Figure 1 This is a flowchart illustrating the preparation method of a traditional Chinese medicine composition for treating osteoporosis according to the present invention. Detailed Implementation

[0014] The principles and features of the present invention are described below with reference to the accompanying drawings. The examples given are only for explaining the present invention and are not intended to limit the scope of the present invention.

[0015] Example 1 like Figure 1 As shown, a traditional Chinese medicine composition for treating osteoporosis is prepared from the following herbs: Astragalus membranaceus, Dioscorea opposita, Citrus medica, Angelica sinensis, Citrus reticulata peel, Codonopsis pilosula, Eucommia ulmoides leaf, Ophiopogon japonicus, Cistanche deserticola, Ziziphus jujuba seed, Poria cocos, and Ganoderma lucidum.

[0016] Traditional Chinese medicine (TCM) offers unique advantages in preventing and treating osteoporosis, including holistic regulation, multi-target intervention, and high safety. Osteoporosis falls under the TCM categories of "bone atrophy," "bone dryness," and "bone obstruction," with its root cause being deficiency of both the spleen and kidneys, accompanied by insufficient qi and blood, obstructed meridians, and invasion of external pathogens. The kidneys govern bones and produce marrow, while the spleen is the source of qi and blood, governing muscles and limbs. Spleen deficiency leads to insufficient qi and blood production, failing to nourish tendons and bones; kidney deficiency results in insufficient bone marrow production, depriving bones of nourishment. Qi stagnation and blood stasis, or deficiency of both qi and blood, can lead to insufficient local nutrient supply to the bones; invasion of wind, cold, and dampness by pathogens obstructs the flow of qi and blood in the body and meridians, preventing the bones from receiving warmth and nourishment for a long time, resulting in decreased bone density. Therefore, strengthening the spleen and replenishing qi, harmonizing the blood and unblocking obstructions are the fundamental principles of treatment.

[0017] Astragalus and Codonopsis are the principal herbs, invigorating qi and strengthening the spleen, consolidating the exterior and raising yang, addressing the root of acquired constitution by nourishing qi and blood to replenish innate constitution; Eucommia leaves and Cistanche deserticola tonify kidney yang, replenish essence and blood, and strengthen tendons and bones; Dioscorea and Ganoderma lucidum tonify qi and nourish yin, strengthen the spleen and benefit the lungs and kidneys; Angelica sinensis tonifies blood and invigorates blood, serving as assistant herbs to assist the principal herbs in strengthening the spleen and kidneys, invigorating qi and nourishing blood; Citrus medica and Citrus reticulata peel regulate qi and harmonize the middle jiao, dry dampness and resolve phlegm, ensuring that tonification is not stagnant; Ziziphus jujuba seed and Poria cocos calm the mind and soothe the nerves, strengthen the spleen and eliminate dampness; Ophiopogon japonicus nourishes yin and clears the heart, assisting in mitigating the warming and drying nature, serving as adjuvant herbs; the entire formula works synergistically to invigorate qi and strengthen the spleen, tonify the kidneys and replenish essence. This formula nourishes blood and qi, relieves pain, and strengthens bones, addressing the core pathogenesis of osteoporosis caused by spleen and kidney deficiency and insufficient qi and blood. It not only focuses on bones but also emphasizes the regulation of overall function. By regulating spleen and kidney function and improving qi and blood, it achieves a comprehensive effect of strengthening bones, relieving pain, and improving physical strength, reflecting the advantages of traditional Chinese medicine's "prevention of disease" and holistic approach. All ingredients are selected from the list of medicinal and edible homologous substances published by the National Health Commission, ensuring high safety and suitability for long-term consumption. The drugs used in this invention are inexpensive, reducing the economic burden on patients.

[0018] Example 2 This embodiment is a further improvement on embodiment 1, as detailed below: The traditional Chinese medicine composition is prepared from the following parts by weight of traditional Chinese medicine: Astragalus membranaceus 4-6 parts, Dioscorea opposita 2-4 parts, Citrus medica 1-2 parts, Angelica sinensis 2-4 parts, Citrus reticulata peel 2-4 parts, Codonopsis pilosula 2-4 parts, Eucommia ulmoides leaf 4-6 parts, Ophiopogon japonicus 1-2 parts, Cistanche deserticola 1-2 parts, Ziziphus jujuba var. spinosa 1-3 parts, Poria cocos 1-3 parts, Ganoderma lucidum 2-4 parts.

[0019] Astragalus: It has a sweet taste and slightly warm nature, and enters the spleen and lung meridians. It has the effects of strengthening the spleen and replenishing the middle jiao, raising yang and lifting prolapse, benefiting wei qi and consolidating the exterior, promoting diuresis and reducing swelling, and promoting tissue regeneration and detoxification. Modern medical research has proven that astragalus can resist oxidation, inflammation, and tumors, enhance immunity, and improve cardiovascular health.

[0020] Yam: Strengthens the spleen, nourishes the lungs, tonifies the kidneys, and benefits essence. It treats spleen deficiency diarrhea, chronic dysentery, consumptive cough, diabetes, seminal emission, leukorrhea, and frequent urination. It can nourish the spleen and stomach, promote body fluid production and benefit the lungs, and tonify the kidneys and astringe essence. Modern medical research has proven that yam has anti-aging, anti-tumor, anti-fatigue, and anti-harmful substance stimulation effects; it regulates metabolism, enhances immune function, promotes growth, regulates endocrine function, regulates kidney function, stimulates the hematopoietic system, and regulates the nervous system.

[0021] Buddha's Hand: It soothes the liver and regulates qi, harmonizes the stomach and relieves pain, and dries dampness and resolves phlegm. Modern medical research has proven that Buddha's Hand has antidepressant, antibacterial, anti-inflammatory, anticancer, antitumor, anti-aging, and blood pressure-lowering effects.

[0022] Angelica sinensis: It nourishes and invigorates blood, regulates menstruation and relieves pain, and moistens the intestines to relieve constipation. It is commonly used for blood deficiency and chlorosis, dizziness and palpitations, irregular menstruation, amenorrhea and dysmenorrhea, abdominal pain due to deficiency and cold, rheumatic pain, traumatic injuries, carbuncles and sores, and constipation due to intestinal dryness. Modern medical research has proven that Angelica sinensis has anti-anemic, peripheral circulation-improving, diuretic, analgesic, and liver-protective effects.

[0023] Citrus reticulata peel: It can resolve phlegm and relieve cough. It can also be used for symptoms such as spleen and stomach qi stagnation, abdominal distension, poor appetite, vomiting and diarrhea, indigestion, drying dampness and resolving phlegm, nausea and vomiting, heaviness in the limbs, increased vaginal discharge, cough and shortness of breath. However, it should be noted that those with weak constitution or lung heat should not take Citrus reticulata peel. Modern medical research has proven that Citrus reticulata peel has the effects of lowering blood lipids, anti-oxidation, anti-aging, anti-inflammation, anti-allergy, regulating immunity, and protecting the cardiovascular and cerebrovascular systems.

[0024] Codonopsis pilosula: It is sweet in taste and neutral in nature; it enters the spleen and lung meridians; it has the effects of strengthening the spleen and lungs, nourishing blood and promoting body fluids. Modern medical research has proven that Codonopsis pilosula also has a variety of pharmacological effects such as enhancing the body's immunity, protecting the gastrointestinal mucosa and resisting ulcers, promoting hematopoietic function, regulating blood sugar, and delaying aging; at the same time, Codonopsis pilosula is also a health product and can be added to the diet.

[0025] Eucommia ulmoides leaves: slightly pungent and warm in nature, they enter the liver and kidney meridians, and have the effects of tonifying the liver and kidneys, strengthening tendons and bones, and lowering blood pressure. They are mainly used to treat liver and kidney deficiency, lower back and knee weakness, and general weakness of tendons and bones. Modern medical research has proven that Eucommia ulmoides leaves are rich in nutrients, including vitamins B1 and E, β-carotene, 17 kinds of free amino acids, and 15 kinds of trace elements such as germanium and selenium. The crude protein content of Eucommia ulmoides leaves is higher than that of corn, millet, sorghum, and potatoes, and comparable to that of barley and wheat. Essential fatty acids are indispensable for maintaining normal metabolism; Eucommia ulmoides leaves contain 1.59% linoleic acid and 45.85% linolenic acid by mass. The active ingredients of Eucommia ulmoides leaves include flavonoids, iridoids, phenylpropanoids, lignans, polysaccharides, and Eucommia ulmoides rubber, etc. Its main pharmacological effects include lowering blood pressure, lowering blood lipids, lowering blood sugar, anti-inflammatory and antiviral effects, anti-fatigue effects, strengthening tendons and bones, and anti-aging effects.

[0026] Ophiopogon japonicus: It nourishes yin and generates fluids, moistens the lungs and clears the heart, relieves irritability and calms the mind. It can be used for symptoms such as irritability and palpitations caused by yin deficiency with heat in the heart. Modern medical research has proven that Ophiopogon japonicus contains a variety of saponins and high levels of isoflavones, which have the effects of nourishing yin and moistening the lungs, protecting the cardiovascular system, enhancing immune function, and lowering blood sugar.

[0027] Cistanche deserticola: It can treat symptoms such as kidney yang deficiency, depletion of essence and blood, cold pain in the lower back and knees, tinnitus, blurred vision, leukorrhea, frequent urination, metrorrhagia, infertility, and constipation. Modern medical research has proven that Cistanche deserticola contains phenylethanoid glycosides, iridoids, lignans, polysaccharides, more than a dozen amino acids, and various alkaloids, and is rich in trace elements needed by the human body. Among them, total phenylethanoid glycosides are the main active ingredients in Cistanche deserticola, which have functions such as improving male sexual function, treating female infertility due to cold uterus, anti-oxidation, anti-aging, improving immunity, and enhancing memory.

[0028] Sour jujube seed: Its main functions are to nourish the liver, calm the mind, soothe the nerves, and reduce sweating. It is used to treat insomnia due to deficiency and restlessness, palpitations, thirst, and night sweats. Its main pharmacological effects include analgesia, anticonvulsant, sedation, and hypnosis.

[0029] Poria cocos: Sweet and bland in taste, neutral in nature. It enters the heart, lung, spleen, and kidney meridians. It promotes diuresis and eliminates dampness, strengthens the spleen, and calms the mind. It is used for edema with scanty urine, phlegm retention with dizziness and palpitations, spleen deficiency with poor appetite, loose stools and diarrhea, restlessness, palpitations, and insomnia.

[0030] Reishi mushroom: It has the effects of tonifying qi and calming the mind, relieving cough and asthma. It is mainly used to treat restlessness, insomnia, palpitations, cough with excessive phlegm, and general weakness. The pharmacological effects of reishi mushroom include immune regulation, lowering blood sugar, lowering blood lipids, antioxidation, anti-aging, and anti-tumor effects; the triterpenoids in reishi mushroom can purify the blood and protect liver function; various preparations of reishi mushroom have sedative, anticonvulsant, cardiotonic, antiarrhythmic, antihypertensive, and antitussive and asthma-relieving effects; in addition, reishi mushroom also has anticoagulant, platelet aggregation inhibitory, and anti-allergic effects.

[0031] The traditional Chinese medicine composition is in the form of capsules, pills, tablets, or granules. Forming it into capsules, pills, tablets, or granules makes it palatable, convenient to take, and improves patient compliance.

[0032] Example 3 A method for preparing a traditional Chinese medicine composition for treating osteoporosis, comprising the following steps: Step 1: Grind the following ingredients, weighed according to their weight percentages, into coarse powder: Astragalus membranaceus, Dioscorea opposita, Citrus medica, Angelica sinensis, Citrus reticulata peel, Codonopsis pilosula, Eucommia ulmoides leaf, Ophiopogon japonicus, Cistanche deserticola, Ziziphus jujuba seed, Poria cocos, and Ganoderma lucidum Step 2: Weigh out the coarse powder from Step 1 according to the weight proportions, add water and boil several times. After boiling for a period of time, filter and concentrate to obtain the extract. Step 3: Add ethanol to the extract obtained in Step 2, stir well, let stand for a period of time, and then filter. Step 4: Recover the ethanol from the filtrate of Step 3, concentrate it to obtain an extract, and dry the extract to obtain a dry extract; Step 5: Crush the dry extract from Step 4 into powder, add excipients, and prepare capsules, pills, tablets, or granules.

[0033] It is easy to prepare, requires no complicated extraction, has low cost, and is easy to industrialize.

[0034] Step 2 specifically includes: weighing the coarse powder pulverized in Step 1 according to the weight proportions, adding water and decocting twice, each time adding water in an amount 12 times the total weight of the medicinal materials, each time decocting for 1.5 hours, filtering, concentrating the filtrate to obtain an extract with a relative density of 1.15 to 1.25 at 25°C; Step 3 specifically includes: adding 5 times the volume of 70% to 99% ethanol to the extract obtained in step 2 until the alcohol content of the precipitate is 50% to 80%, stirring well, letting stand for 8 to 16 hours, and filtering. Step 4 specifically includes: recovering the ethanol from the filtrate of step 3, concentrating the filtrate to obtain an extract with a relative density of 1.3 to 1.4 at 50 to 80°C, and drying the extract to obtain a dry extract.

[0035] Example 4 This embodiment is a further improvement on embodiment 3, as detailed below: Concentration includes vacuum membrane concentration, direct heating open-top concentration, single-effect concentrator concentration, or double-effect concentrator concentration.

[0036] Drying methods include hot air circulation drying, vacuum drying, fluidized bed drying, spray drying, or microwave drying.

[0037] Example 5 Application of a traditional Chinese medicine composition for treating osteoporosis: applying the traditional Chinese medicine composition for treating osteoporosis to drugs or health foods for the prevention or treatment of osteoporosis. Specific Implementation Example 1 Step 1: Select 9g of Astragalus membranaceus, 6g of Dioscorea opposita, 3g of Citrus medica, 6g of Angelica sinensis, 6g of Citrus reticulata peel, 6g of Codonopsis pilosula, 10g of Eucommia ulmoides leaf, 3g of Ophiopogon japonicus, 3g of Cistanche deserticola, 4g of Ziziphus jujuba seed, 4g of Poria cocos and 6g of Ganoderma lucidum, mix them together and grind them into coarse powder. Step 2: Weigh out the coarse powder from Step 1 according to the weight proportions, add water and decoct twice, each time adding water in an amount 12 times the total mass of the medicinal materials, and each decoction time is 1.5 hours. Filter, and concentrate the filtrate through a vacuum membrane to obtain an extract with a relative density of 1.15 at 25℃. Step 3: Add 5 times the volume of 99% ethanol to the extract obtained in Step 2 until the alcohol content of the precipitate is 50%, stir well, let stand for 16 hours, and filter. Step 4: Recover the ethanol from the filtrate of Step 3, concentrate the filtrate through a vacuum membrane to obtain an extract with a relative density of 1.4 at 50°C, and dry the extract by fluidized bed boiling to obtain a dry extract. Step 5: Crush the dry extract from Step 4 into powder, add dextrin, and make capsules. Specific Implementation Example 2 Step 1: Select 9g of Astragalus membranaceus, 6g of Dioscorea opposita, 3g of Citrus medica, 6g of Angelica sinensis, 6g of Citrus reticulata peel, 6g of Codonopsis pilosula, 10g of Eucommia ulmoides leaf, 3g of Ophiopogon japonicus, 3g of Cistanche deserticola, 4g of Ziziphus jujuba seed, 4g of Poria cocos and 6g of Ganoderma lucidum, mix them together and grind them into coarse powder. Step 2: Weigh the coarse powder from Step 1 according to the weight proportions, add water and decoct twice, each time adding water in an amount 12 times the total mass of the medicinal materials, and each decoction time is 1.5 hours. Filter, and concentrate the filtrate through a vacuum membrane to obtain an extract with a relative density of 1.25 at 25℃. Step 3: Add 5 times the volume of 70% ethanol to the extract obtained in Step 2 until the alcohol content of the precipitate is 60%. Stir well, let stand for 8 hours, and then filter. Step 4: Recover the ethanol from the filtrate of Step 3, concentrate the filtrate through a vacuum membrane to obtain an extract with a relative density of 1.3 at 80°C, and dry the extract by fluidized bed boiling to obtain a dry extract. Step 5: Crush the dry extract from Step 4 into powder, add microcrystalline cellulose, and make tablets.

[0040] Preliminary clinical observation In preliminary exploratory applications, it was found that osteoporosis patients taking this traditional Chinese medicine composition generally experienced relief from core symptoms such as lower back pain and weakness in the lower back and knees, and their physical functions improved. Patients with a confirmed diagnosis via imaging examinations showed particularly significant improvement in symptoms and subjective feelings, demonstrating the potential value of this composition in alleviating clinical symptoms of osteoporosis. The following are quantitative assessment data from 26 typical patients who completed full follow-up, clearly showing a consistent trend of improvement in both symptoms and function.

[0041] Table 1. General patient information and symptom and functional scores before and after medication (n=26) Note: The TCM syndrome score covers symptoms such as lower back pain, soreness and weakness in the lower back and knees, fatigue, and dizziness; the ODI (Oswestry Disability Index) is used to assess the impact of lower back pain on daily functioning, and the higher the score, the more severe the dysfunction.

[0042] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A traditional Chinese medicine composition for treating osteoporosis, characterized in that, The traditional Chinese medicine composition is prepared from the following traditional Chinese medicines: Astragalus membranaceus, Dioscorea opposita, Citrus medica, Angelica sinensis, Citrus reticulata peel, Codonopsis pilosula, Eucommia ulmoides leaf, Ophiopogon japonicus, Cistanche deserticola, Ziziphus jujuba seed, Poria cocos, and Ganoderma lucidum.

2. The traditional Chinese medicine composition for treating osteoporosis according to claim 1, characterized in that, The traditional Chinese medicine composition is prepared from the following traditional Chinese medicines in parts by weight: Astragalus membranaceus 4-6 parts, Dioscorea opposita 2-4 parts, Citrus medica 1-2 parts, Angelica sinensis 2-4 parts, Citrus reticulata peel 2-4 parts, Codonopsis pilosula 2-4 parts, Eucommia ulmoides leaf 4-6 parts, Ophiopogon japonicus 1-2 parts, Cistanche deserticola 1-2 parts, Ziziphus jujuba var. spinosa 1-3 parts, Poria cocos 1-3 parts, and Ganoderma lucidum 2-4 parts.

3. The traditional Chinese medicine composition for treating osteoporosis according to claim 1, characterized in that, The traditional Chinese medicine composition is in the form of capsules, pills, tablets, or granules.

4. A method for preparing a traditional Chinese medicine composition for treating osteoporosis, characterized in that, The preparation of the traditional Chinese medicine composition for treating osteoporosis as described in any one of claims 1 to 3 comprises the following steps: Step 1: Grind the following ingredients, weighed according to their weight percentages, into coarse powder: Astragalus membranaceus, Dioscorea opposita, Citrus medica, Angelica sinensis, Citrus reticulata peel, Codonopsis pilosula, Eucommia ulmoides leaf, Ophiopogon japonicus, Cistanche deserticola, Ziziphus jujuba seed, Poria cocos, and Ganoderma lucidum Step 2: Weigh out the coarse powder from Step 1 according to the weight proportions, add water and boil several times. After boiling for a period of time, filter and concentrate to obtain the extract. Step 3: Add ethanol to the extract obtained in Step 2, stir well, let stand for a period of time, and then filter. Step 4: Recover the ethanol from the filtrate of Step 3, concentrate it to obtain an extract, and dry the extract to obtain a dry extract; Step 5: Crush the dry extract from Step 4 into powder, add excipients, and prepare capsules, pills, tablets, or granules.

5. The method for preparing the traditional Chinese medicine composition for treating osteoporosis according to claim 4, characterized in that, Step 2 specifically includes: weighing the coarse powder pulverized in step 1 according to the weight proportions, adding water and decocting twice, each time adding water at a rate of 12 times the total weight of the medicinal materials, and each decoction time being 1.5 hours, filtering, concentrating the filtrate to obtain an extract with a relative density of 1.15 to 1.25 at 25°C. Step 3 specifically includes: adding 5 times the volume of 70% to 99% ethanol to the extract obtained in step 2 until the alcohol content of the precipitate is 50% to 80%, stirring well, letting stand for 8 to 16 hours, and filtering. Step 4 specifically includes: recovering the ethanol from the filtrate of step 3, concentrating the filtrate to obtain an extract with a relative density of 1.3 to 1.4 at 50 to 80°C, and drying the extract to obtain a dry extract.

6. The method for preparing the traditional Chinese medicine composition for treating osteoporosis according to claim 4, characterized in that, The concentration methods include vacuum film concentration, direct heating open-top concentration, single-effect concentrator concentration, or double-effect concentrator concentration.

7. The method for preparing the traditional Chinese medicine composition for treating osteoporosis according to claim 4, characterized in that, The drying process includes hot air circulation drying, vacuum drying, fluidized bed boiling drying, spray drying, or microwave drying.

8. The application of a traditional Chinese medicine composition for treating osteoporosis, characterized in that, The traditional Chinese medicine composition for treating osteoporosis as described in any one of claims 1 to 3 may be used in drugs or health foods for the prevention or treatment of osteoporosis.

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