Bacillus velezensis with broad-spectrum antibacterial activity and application thereof in prevention and treatment of necrotic enteritis of poultry

By screening and developing the Bacillus belysus GDG25CB056 strain, the problems of lack of broad-spectrum antibacterial activity and environmental tolerance in existing technologies have been solved, achieving efficient inhibition of Clostridium perfringens and improvement of intestinal health, thus promoting the green development of poultry farming.

CN122128164APending Publication Date: 2026-06-02SOUTH CHINA AGRICULTURAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SOUTH CHINA AGRICULTURAL UNIVERSITY
Filing Date
2026-03-18
Publication Date
2026-06-02

AI Technical Summary

Technical Problem

Existing technologies lack Bacillus belysus resources with broad-spectrum antibacterial activity, environmental tolerance, and high efficiency in antagonizing Clostridium perfringens, resulting in poor prevention and control of necrotic enteritis in poultry, and antibiotic use leads to drug residues and drug resistance problems.

Method used

A strain of Bacillus belyssus GDG25CB056 is provided, which has broad-spectrum antibacterial activity and high heat resistance. It can secrete a variety of enzymes, adapt to the gastrointestinal environment, and inhibit a variety of pathogens, especially Clostridium perfringens. It can be used to prepare microecological preparations and drugs.

Benefits of technology

It effectively inhibits Clostridium perfringens infection, alleviates intestinal inflammation, enhances intestinal barrier function, reduces the incidence of intestinal diseases, reduces antibiotic use, and promotes the green and sustainable development of animal husbandry.

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Abstract

This invention discloses a strain of *Bacillus belyceae* with broad-spectrum antibacterial activity and its application in the prevention and treatment of necrotic enteritis in poultry. The *Bacillus belyceae* strain provided by this invention (… Bacillus from Velez The genome of strain GDG25CB056 is approximately 3.91 Mb in size, contains no virulence factors, and is rich in gene clusters encoding non-ribosomal peptides and polyketide synthases. Studies have confirmed that this strain exhibits significant growth advantages, strong tolerance to high temperatures, gastric acid, and bile salts, which facilitates intestinal colonization. It can produce siderophores and various enzymes, and has overcome the technical bottleneck of a narrow antibacterial spectrum, possessing broad-spectrum antibacterial activity, especially strong specific antagonistic activity against Clostridium perfringens. In vivo experiments have shown that this strain can significantly reduce the Clostridium perfringens load in the cecum of chicks with necrotizing enterocolitis, alleviate intestinal congestion and swelling, repair damaged intestinal villi, and enhance mucosal barrier function, providing a safe and efficient strain resource for the prevention and treatment of bacterial enteric diseases.
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