Methods and compositions for topical expression of rna for administration

By administering RNA molecules systemically and utilizing the endogenous mechanisms of monocytes and macrophages to express them at sites of acute inflammation, the treatment challenges of acute inflammation sites have been solved, achieving effective healing and functional recovery of heart and brain tissues.

CN122139035APending Publication Date: 2026-06-02BIONTECH SE +2
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
BIONTECH SE
Filing Date
2024-09-06
Publication Date
2026-06-02

AI Technical Summary

Technical Problem

Existing technologies struggle to effectively deliver proteins to sites of acute inflammation. Local administration is difficult to achieve, and systemic administration may lead to drug diffusion or immune reactions, making it ineffective in treating acute inflammation in the heart or brain.

Method used

By administering RNA molecules systemically, they are expressed at sites of acute inflammation. The RNA molecules are then delivered to the site of inflammation using endogenous mechanisms of monocytes and macrophages, encoding therapeutic proteins to promote tissue repair and functional recovery.

Benefits of technology

It achieves effective expression of RNA molecules at the site of acute inflammation, enhances healing and organ function, reduces the side effects of systemic administration, and improves treatment efficacy.

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Abstract

This article discloses methods for local expression and administration of RNA molecules at sites of acute inflammation, methods for treating tissue or organ damage in subjects characterized by sites of acute inflammation in tissues or organs, methods for treating subjects with sites of acute inflammation in tissues or organs, methods for treating tissue damage in the heart or brain in subjects caused by local ischemia, and medical products or kits suitable for administration and local expression at sites of acute inflammation.
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