A lotion formulation for treating bone fracture trauma and a method of preparing the same

Abstract

The application provides a lotion formula for treating fracture trauma and a preparation method thereof. The lotion formula has the effects of activating blood, removing swelling, dispelling wind and dredging collaterals, can simultaneously play the synergistic effects of anti-inflammation, antibiosis, analgesia and circulation improvement, and compared with simple western medicine for anti-inflammation and analgesia, can promote trauma repair from the whole. Secondly, the external treatment method of traditional Chinese medicine has unique advantages. Local fumigation and washing can make the effective components of the medicine directly reach the disease site, the local concentration is high, the effect is rapid, and the stimulation of oral medicine on the gastrointestinal tract and the whole body reaction are avoided. For postoperative infection or inflammation, the method can be used as an effective auxiliary or replacement, and provides a replacement scheme with low recurrence rate and small side effects. Finally, the method also has good safety and compliance, has few adverse reactions, and is simple to operate, so that patients are more willing to adhere to it.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine lotions, and particularly to a lotion formula for treating fracture and trauma and its preparation method. Background Art

[0002] Fractures and related traumas are common and frequently-occurring diseases in orthopedic clinics, covering various types such as distal radius fractures, metacarpal fractures, tendon ruptures, joint ligament injuries, and peripheral nerve injuries. After surgery, patients often suffer from complications such as limb swelling, pain, joint stiffness, muscle atrophy, tissue adhesion, and limb dysfunction, which seriously affect the quality of life and rehabilitation process of patients.

[0003] At present, for the rapid rehabilitation treatment after fractures, oral non-steroidal anti-inflammatory analgesics and traditional Chinese patent medicines for promoting blood circulation and removing blood stasis are mainly used. Such treatment plans have many inevitable defects: First, oral medications are absorbed through the gastrointestinal tract to take effect. After being distributed throughout the body, the drug concentration at the local lesion is low, and the targeting of local rehabilitation after fractures is poor. The overall curative effect is limited, and it is difficult to quickly relieve core problems such as local swelling, stiffness, and adhesion. Second, long-term oral non-steroidal anti-inflammatory drugs are prone to cause adverse reactions such as nausea, vomiting, and gastrointestinal mucosal damage. Traditional Chinese patent medicines for promoting blood circulation and removing blood stasis are also likely to burden the liver and kidney functions, especially not suitable for the elderly, the weak, and patients with underlying gastrointestinal diseases. Third, the treatment course of oral medications is long and the treatment cost is high, increasing the economic burden and the risk of medication compliance of patients.

[0004] Most of the existing externally applied lotions in clinical use have problems such as single formula compatibility and insufficient efficacy targeting. They can only achieve basic detumescence and pain relief, and cannot meet the multiple requirements of relaxing tendons and activating collaterals, reconnecting tendons and bones, improving local circulation, relieving tissue adhesion, and promoting nerve and tendon repair. It is difficult to comprehensively solve various rehabilitation problems after fracture and trauma surgery. At the same time, the preparation process of existing traditional Chinese medicine external powders is extensive, and there is a lack of standardized design for the particle size of medicinal material pulverization, mixing uniformity, and sterilization method, resulting in low dissolution rate of active ingredients of the drug and poor efficacy stability between batches, unable to fully exert the compatibility advantages of traditional Chinese medicine compound prescriptions. The solubility problem of traditional Chinese medicine powders also directly affects the therapeutic effect of external fumigation and washing. Summary of the Invention

[0005] In order to solve the technical problems existing in the prior art, the present invention provides the following technical solutions: On the one hand, a lotion formula for treating fracture and trauma is provided, which includes the following traditional Chinese medicine raw material components by mass parts: 80 - 100 parts of lycopodium clavatum; 80 - 100 parts of herba divaricatae; 50 - 70 parts of schizonepeta tenuifolia; 50 - 70 parts of ledebouriella seseloides; 80 - 100 parts of homalomena occulta; 50 - 70 parts of clematis chinensis; 50 - 70 parts of bombyx batryticatus; 50 - 70 parts of eupolyphaga seu steleophaga.

[0006] On the other hand, a method for preparing a lotion formula for treating fracture injuries is provided, comprising the following steps: Step 1: Pre-treatment of medicinal materials. The following herbs are cleaned and selected separately: *Shenjincao*, *Tougucao*, *Jingjie*, *Fangfeng*, *Qiannianjian*, *Weilingxian*, *Jiangcan*, and *Dibiechong*. Impurities and non-medicinal parts are removed, and the herbs are dried at low temperature until the moisture content is ≤8%. Step 2: Grind and sieve. Grind each of the dried medicinal materials separately and pass them through an 80-100 mesh standard sieve. Collect the fine powder that passes through the sieve. Step 3: Weigh and mix. Weigh the fine powder of each herb according to the prescription weight ratio, place them in a mixer and mix for 30-45 minutes until the material has a uniform color. Step 4: Dispensing and sterilization. Dispense the well-mixed powder into sterile containers and seal them. Sterilize by ultraviolet irradiation for 30 minutes to obtain the finished powder product.

[0007] The beneficial effects of the technical solutions provided in the embodiments of the present invention include at least the following: 1. Targeted drug delivery provides rapid onset of action and completely avoids the systemic adverse reactions of oral medications. This invention uses an external fumigation and washing method for drug delivery. The active ingredients can penetrate the skin and act directly on the lesion, resulting in high drug concentration at the affected area, strong targeting, and rapid onset of action. It can quickly relieve symptoms such as local swelling, pain, and stiffness. At the same time, it completely avoids the gastrointestinal irritation of oral medications and the potential burden on liver and kidney function. There are no significant systemic adverse reactions, making it suitable for a wide range of people, especially the elderly, the frail, and patients with underlying gastrointestinal diseases. It solves the core defects of existing oral medications, such as large adverse reactions and poor targeting.

[0008] 2. Scientifically formulated and comprehensive, addressing post-fracture rehabilitation challenges through multiple targets. Based on traditional Chinese medicine orthopedic theory, this invention employs a combination of principal, assistant, and adjuvant herbs to not only achieve basic swelling and pain relief, but also to address multiple effects such as relaxing muscles and tendons, dispelling wind and dampness, promoting bone and tendon healing, and facilitating nerve and tendon repair. It can comprehensively resolve various complications after fracture surgery, including joint stiffness, tissue adhesions, limb numbness, and bone and tendon disconnection. Compared to existing topical washes with single formulas and limited efficacy, this invention offers more comprehensive treatment dimensions and a wider range of clinical applications, suitable for rehabilitation treatment of various orthopedic trauma conditions such as post-fracture surgery, tendon rupture repair, joint and ligament injuries, and peripheral nerve injuries.

[0009] 3. Standardized preparation process effectively solves the problems of poor solubility and unstable efficacy of traditional Chinese medicine powders. This invention employs a standardized preparation process including low-temperature drying, 80-100 mesh pulverization and sieving, three-dimensional mixing, and low-temperature ultraviolet sterilization. This ensures that the effective components of the medicinal materials are not destroyed by high temperatures, and by precisely controlling the particle size, the specific surface area of ​​the medicinal materials is increased, significantly improving the dissolution rate of the effective components and solving the industry pain point of insufficient solubility in traditional powders. At the same time, the standardized mixing and sterilization process ensures the stability of efficacy between batches, overcoming the shortcomings of existing crude and unstable efficacy preparation processes for external powders.

[0010] 4. Low treatment cost and excellent patient compliance. The ingredients in the formula of this invention are all commonly used Chinese herbal medicines, which are readily available and inexpensive. Compared with long-term oral medication, this significantly reduces the economic burden of treatment for patients. At the same time, the finished product of this invention is a portable powder, which is easy to use for fumigation and washing. Patients can complete the treatment at home without hospitalization or professional medical staff. The treatment method is convenient, and the patient's treatment compliance is significantly improved, which can ensure the continuity of rehabilitation treatment.

[0011] 5. The treatment is effective, with a low recurrence rate and good safety profile. Clinical cases have verified that the lotion formula of this invention, combined with functional exercises, can effectively promote the recovery of limb function after fracture surgery. It has significant improvement effects on joint stiffness, tissue adhesions, and sequelae of nerve damage, with a high overall effective rate. Moreover, no obvious adverse reactions occur during the treatment process, and the recurrence rate of symptoms after discontinuation of the medication is low. Compared with the symptomatic treatment of Western medicine, it can fundamentally improve the local pathological state, achieving both symptomatic and radical treatment. Attached Figure Description

[0012] To more clearly illustrate the technical solutions in the embodiments of the present invention, the accompanying drawings used in the description of the embodiments will be briefly introduced below. Obviously, the accompanying drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0013] Figure 1 This is a comparison of the postoperative rehabilitation effects of a patient with distal radius fracture before and after treatment with this formula, as described in Embodiment 4 of the present invention (the left side is the preoperative imaging image of the right wrist joint, and the right side is the postoperative imaging image of the right wrist joint). Figure 2 This is a comparison of the postoperative rehabilitation effects of metacarpal fracture patients before and after treatment with this formula, as described in Embodiment 5 of the present invention (the left side is the preoperative imaging image of the right hand, and the right side is the imaging image of the right hand 3 months after surgery). Figure 3This is a comparison image of the rehabilitation effect of the distal radioulnar joint injury of the patient before and after treatment with this formula as described in Embodiment 7 of the present invention (the left side is the magnetic resonance image of the right wrist joint before treatment, and the right side is the follow-up image of the right wrist joint after treatment). Figure 4 This is a recovery effect diagram of a patient with forearm crush injury and radial nerve injury after treatment with this formula, as described in Embodiment 8 of the present invention. Detailed Implementation

[0014] The technical solution of the present invention will now be described with reference to the accompanying drawings.

[0015] In embodiments of the present invention, words such as "exemplarily," "for example," etc., are used to indicate that something is an example, illustration, or description. Any embodiment or design described as "exemplary" in the present invention should not be construed as being more preferred or advantageous than other embodiments or designs. Specifically, the use of the word "exemplary" is intended to present the concept in a concrete manner. Furthermore, in embodiments of the present invention, the meaning expressed by "and / or" can be both, or either one.

[0016] In the embodiments of this invention, the terms "image" and "picture" may sometimes be used interchangeably. It should be noted that, without emphasizing the distinction between them, they convey the same meaning. Similarly, the terms "of," "corresponding (relevant)," and "corresponding" may sometimes be used interchangeably. It should be noted that, without emphasizing the distinction between them, they convey the same meaning.

[0017] In this embodiment of the invention, sometimes a subscript such as W1 may be mistakenly written as a non-subscript form such as W1. When the difference is not emphasized, the meaning they express is the same.

[0018] To make the technical problems, technical solutions and advantages of the present invention clearer, a detailed description will be given below in conjunction with the accompanying drawings and specific embodiments.

[0019] This invention provides a lotion formula and preparation method for treating fracture injuries. Through scientific compound formulation of traditional Chinese medicine and standardized preparation process, it achieves the core effects of promoting blood circulation, removing blood stasis, relaxing muscles and tendons, dispelling wind and dampness, and promoting bone healing. Local fumigation and washing deliver the medicine directly to the affected area, with rapid onset of action and no systemic adverse reactions. At the same time, the preparation process has a high degree of standardization, effectively solving the industry pain point of poor solubility of traditional Chinese medicine powders. The drug dissolution rate and efficacy stability are excellent, which can comprehensively solve the rehabilitation problems after fracture injury surgery.

[0020] I. Formula Composition The lotion formula for treating fracture injuries disclosed in this invention addresses the current shortcomings of oral medications for rapid rehabilitation after fracture surgery, which are expensive, have limited efficacy, and also cause adverse reactions such as gastrointestinal issues.

[0021] Now a lotion formula for accelerating the rehabilitation after fracture surgery is provided. Using traditional Chinese medicine decoction pieces as raw materials, by mass parts, it includes the following components: Lycopodium clavatum 80 - 100 parts; Speranskia tuberculata 80 - 100 parts; Schizonepeta tenuifolia 50 - 70 parts; Saposhnikovia divaricata 50 - 70 parts; Homalomena occulta 80 - 100 parts; Clematis chinensis 50 - 70 parts; Bombyx batryticatus 50 - 70 parts; Eupolyphaga seu Steleophaga 50 - 70 parts.

[0022] In the formula, the monarch drugs, Lycopodium clavatum and Speranskia tuberculata: expel wind and remove dampness, relax tendons and activate collaterals to relieve pain; the minister drugs, Homalomena occulta and Clematis chinensis: dispel wind-dampness, strengthen muscles and bones, and stop arthralgia pain; the assistant drugs, Schizonepeta tenuifolia and Saposhnikovia divaricata: expel wind, relieve exterior syndrome and pain, open the pores and remove cold-dampness; Bombyx batryticatus: dispel wind, resolve phlegm and dredge collaterals; Eupolyphaga seu Steleophaga: break blood stasis, disperse stasis and reconnect tendons and bones. The two insect drugs break phlegm stasis and promote qi and blood circulation. The whole formula takes promoting blood circulation to remove stasis, relaxing tendons and activating collaterals, expelling wind and removing dampness as the main treatment methods, aiming to promote local blood circulation, relieve muscle stiffness and tissue adhesion, promote fracture healing, and restore joint function.

[0023] The lotion formula for treating fracture trauma of the present invention is based on the core theory of fracture healing in traditional Chinese medicine of "removing stasis, generating new tissues, and bone union", with "promoting blood circulation to remove stasis, relaxing tendons and activating collaterals, expelling wind and removing dampness, reconnecting tendons and bones" as the core treatment methods, and is formulated strictly following the compatibility principle of monarch, minister, assistant, and courier drugs. The medicinal properties and compatibility mechanisms of each component are as follows: Monarch drugs: Lycopodium clavatum and Speranskia tuberculata, which are used in combination to form the core of the whole formula for treatment. Lycopodium clavatum is slightly bitter and pungent, warm in nature, and belongs to the liver, spleen, and kidney meridians. Its core efficacy is to expel wind and remove dampness, relax tendons and activate collaterals, especially good at relieving the spasm and limited flexion and extension of tendons and vessels, directly targeting the core pathogenesis of muscle stiffness, joint adhesion, and limited movement after fracture surgery; Speranskia tuberculata is pungent and sweet, warm in nature, and belongs to the liver and kidney meridians, with the effects of expelling wind and removing dampness, relaxing tendons and activating collaterals, and promoting blood circulation to relieve pain. Its medicinal power can penetrate into muscles and bones and reach the affected area, effectively relieving muscle and bone spasms and promoting local blood circulation. The combination of the two drugs achieves the effects of relaxing tendons and activating collaterals, promoting blood circulation to relieve pain, targeting the core symptoms of tendon spasm and joint stiffness after fracture trauma surgery, and laying the treatment foundation for the whole formula.

[0024] Minister drugs: Homalomena occulta and Clematis chinensis, assisting the monarch drugs to enhance the core curative effect and perfect the treatment dimension. Homalomena occulta is bitter and pungent, warm in nature, and belongs to the liver and kidney meridians, with the effects of expelling wind-dampness, strengthening muscles and bones, and stopping arthralgia pain. It can not only assist the monarch drugs to relax tendons and activate collaterals, but also tonify the liver and kidney, strengthen muscles and bones, fitting the pathogenesis characteristics of "long illness affecting the kidney and muscles and bones losing nourishment" after fracture surgery, and promoting the repair of muscle and bone tissues; Clematis chinensis is pungent, salty, and warm in nature, and belongs to the bladder meridian, with the effects of expelling wind-dampness, dredging collaterals, and stopping arthralgia pain. It is good at moving around and can dredge the twelve meridians, effectively dredging meridian stasis, relieving tendon spasm and limb numbness. For the symptoms of meridian blockage and limited movement after fracture surgery, it synergistically enhances the effects of relaxing tendons and activating collaterals, promoting blood circulation to relieve pain with the monarch drugs.

[0025] The adjuvant herbs—Schizonepeta tenuifolia, Saposhnikovia divaricata, Bombyx mori, and Eupolyphaga sinensis—each play their respective roles, achieving a comprehensive treatment that addresses both the symptoms and the root cause. Schizonepeta and Saposhnikovia are a classic pair of pungent and warm exterior-releasing herbs. Both are pungent and slightly warm in nature, and enter the lung and liver meridians. They have the effects of dispelling wind and relieving exterior symptoms, eliminating dampness and relieving pain. They can open the pores and dispel cold and dampness, opening up pathways for the transdermal absorption of the whole formula. At the same time, they can exert anti-inflammatory and antibacterial effects, reducing the risk of postoperative local infection. Bombyx mori is salty and pungent in taste, and neutral in nature. It enters the liver, lung and stomach meridians. It has the effects of dispelling wind and calming fright, resolving phlegm and dissipating nodules, and unblocking the meridians and relieving pain. It is good at treating numbness and difficulty in flexion and extension of limbs caused by meridian obstruction and wind-phlegm entering the meridians. It is especially suitable for postoperative rehabilitation of fractures combined with peripheral nerve damage. Eupolyphaga sinensis is salty and cold in nature, and enters the liver meridian. It has the core effects of breaking up blood stasis and promoting tendon and bone healing. It is a classic medicine in orthopedics. It can not only break up local blood stasis and eliminate swelling and pain, but also promote callus growth and tendon and bone healing. Targeting the core pathogenesis of blood stasis and tendon and bone failure after fracture surgery, it is combined with the principal herb to achieve both blood-activating and meridian-unblocking, pain relief and bone healing.

[0026] The formula is meticulously formulated, combining cold and warm properties, and regulating the ascending and descending functions. It focuses on relaxing muscles and tendons, promoting blood circulation and removing blood stasis, and using wind-dispelling and dampness-removing effects as supplementary measures. It aims to reconnect tendons and bones. The combined effects of the various herbs can synergistically exert multiple pharmacological effects, including anti-inflammatory, antibacterial, analgesic, improvement of local microcirculation, relief of muscle spasms and tissue adhesions, and promotion of fracture healing and nerve and tendon repair. It comprehensively addresses various rehabilitation challenges after fracture and trauma surgery from multiple targets and dimensions.

[0027] II. Preparation Process The reagents and equipment involved in this process can be implemented by referring to existing hospital lotion preparation processes.

[0028] This powder needs to be dissolved in water before it can be used effectively. The solubility of Chinese medicine powder is an issue, which is closely related to the technical process of grinding Chinese medicine into powder.

[0029] Therefore, the present invention also discloses a method for preparing the above-mentioned lotion formula for treating fracture injuries, specifically including the following steps: 1. Pre-treatment of medicinal materials: The eight medicinal materials, namely, *Shenjincao*, *Tougucao*, *Jingjie*, *Fangfeng*, *Qiannianjian*, *Weilingxian*, *Jiangcan*, and *Dibiechong*, are cleaned and selected to remove impurities, non-medicinal parts, and moldy or insect-infested parts. They are then placed in a hot air circulating drying oven and dried at a low temperature of 40-50℃ until the moisture content is ≤8%. This ensures the dryness of the medicinal materials while avoiding the destruction of volatile active ingredients by high temperature. 2. Grinding and sieving: After drying, each medicinal material is separately put into a universal grinder for grinding. After grinding, it is passed through an 80-100 mesh standard sieve. The fine powder under the sieve is collected and the coarse powder on the sieve is discarded. By precisely controlling the particle size, the specific surface area of ​​the medicinal materials is greatly increased, which solves the core problem of low dissolution rate of effective ingredients in Chinese medicine powders and ensures that the effective ingredients can be quickly and fully dissolved in water during the fumigation and washing process. 3. Weighing and mixing: Accurately weigh the fine powders of each medicinal material according to the mass ratio in the prescription, place them in a three-dimensional motion mixer, and mix for 30 - 45 minutes until the color of the mixed powder is uniform. After testing the mixing uniformity, the relative standard deviation RSD of the material is ≤ 2%, ensuring that the content of each component in the medicinal powder per unit dose is uniform and stable, and avoiding the efficacy differences between batches. 4. Subpackaging and sterilization: Pack the uniformly mixed medicinal powder into sterile aluminum foil bags or sealed medicinal containers according to the loading amount of 10 - 20 g per bag, and perform sealing treatment. Place the sealed finished product in an ultraviolet sterilization cabinet and irradiate it with ultraviolet light for 30 minutes. During the sterilization process, control the environmental temperature ≤ 25°C and the relative humidity ≤ 60%. While ensuring the aseptic level of the finished product, avoid the destruction of volatile active ingredients in traditional Chinese medicine by high-temperature sterilization, and finally obtain the finished powder preparation.

[0030] The effects of this formula are described below in combination with examples.

[0031] Example 1, Basic formula This example provides a lotion formula for treating fracture injuries. Calculated by mass份数, the components are: Lycopodium clavatum 80 parts; Speranskia tuberculata 80 parts; Schizonepeta tenuifolia Briq. 50 parts; Saposhnikovia divaricata (Turcz.) Schischk. 50 parts; Homalomena occulta 80 parts; Clematis chinensis Osbeck 50 parts; Bombyx batryticatus 50 parts; Eupolyphaga seu Steleophaga 50 parts.

[0032] Its preparation method includes the following steps: Step 1: Clean and select the above 8 medicinal materials respectively, remove impurities and non-medicinal parts, and place them in a hot air circulation drying oven at 45°C to dry until the moisture content is 7.2%. Step 2: Crush the dried medicinal materials respectively, pass through a 80-mesh standard sieve, and collect the fine powder under the sieve. Step 3: Weigh each medicinal powder according to the prescription amount, place it in a three-dimensional motion mixer and mix for 30 minutes until the color is uniform, and the mixing uniformity RSD is 1.6%. Step 4: Pack the mixed medicinal powder into sterile aluminum foil bags according to the loading amount of 10 g per bag, seal it, and irradiate it with ultraviolet light for 30 minutes to obtain the finished powder preparation.

[0033] Example 2, Preferred formula This example provides a lotion formula for treating fracture injuries. Calculated by mass份数, the components are: Lycopodium clavatum 90 parts; Speranskia tuberculata 90 parts; Schizonepeta tenuifolia Briq. 60 parts; Saposhnikovia divaricata (Turcz.) Schischk. 60 parts; Homalomena occulta 90 parts; Clematis chinensis Osbeck 60 parts; Bombyx batryticatus 60 parts; Eupolyphaga seu Steleophaga 60 parts.

[0034] Its preparation method includes the following steps: Step 1: Clean and select the above 8 medicinal materials respectively, remove impurities and non-medicinal parts, and place them in a hot air circulation drying oven at 40°C to dry until the moisture content is 6.8%. Step 2: Crush the dried medicinal materials respectively, pass through a 100-mesh standard sieve, and collect the fine powder under the sieve. Step 3: Weigh out each powder according to the prescription, place them in a three-dimensional motion mixer and mix for 40 minutes until the color is uniform and the mixing uniformity RSD is 1.2%; Step 4: Distribute the mixed powder into sterile aluminum foil bags at a rate of 20g per bag, seal them, and sterilize them by ultraviolet irradiation for 30 minutes to obtain the finished powder product.

[0035] Example 3, High-dose formulation This embodiment provides a lotion formula for treating fracture injuries, which, by weight, consists of: 100 parts of *Lycopodium clavatum*, 100 parts of *Clematis chinensis*, 70 parts of *Schizonepeta tenuifolia*, 70 parts of *Saposhnikovia divaricata*, 100 parts of *Homalomena occulta*, 70 parts of *Clematis chinensis*, 70 parts of *Bombyx mori*, and 70 parts of *Eupolyphaga sinensis*.

[0036] Its preparation method includes the following steps: Step 1: Clean and select the above 8 medicinal materials separately, remove impurities and non-medicinal parts, and dry them in a 50℃ hot air circulating drying oven until the moisture content is 7.5%; Step 2: Grind the dried medicinal materials into powder, pass them through a 90-mesh standard sieve, and collect the fine powder that passes through the sieve; Step 3: Weigh out each powder according to the prescription, place them in a three-dimensional motion mixer and mix for 45 minutes until the color is uniform and the mixing uniformity RSD is 1.4%; Step 4: Distribute the mixed powder into sterile aluminum foil bags at a rate of 15g per bag, seal them, and sterilize them by ultraviolet irradiation for 30 minutes to obtain the finished powder product.

[0037] The specific embodiments described above can be adjusted by the physician according to the patient's condition.

[0038] Example 4: Clinical Case of Postoperative Rehabilitation for Distal Radius Fracture The patient, Ms. Fang, 53 years old, suffered a distal radius fracture of the right wrist due to trauma on March 2, 2025, and underwent open reduction and internal fixation surgery at our hospital. Three months post-surgery, a follow-up examination revealed swelling and pain in the right wrist, with severely limited flexion, extension, and rotation of the wrist joint, significantly impacting her daily activities.

[0039] Treatment plan: Use the prepared lotion formula from Example 2 for external fumigation and washing treatment. Instructions: Take one packet (20g) of powder, add 1000ml of cold water and soak for 30 minutes. Bring to a boil over high heat, then simmer over low heat for another 30 minutes. First, use the hot steam to fumigate the wrist of the affected limb. When the temperature of the liquid drops to around 40℃, immerse the wrist of the affected limb in the liquid. Each fumigation and washing session should last 30 minutes, twice a day, morning and evening. Follow the fumigation and washing with wrist joint exercises.

[0040] As attached Figure 1The following are the preoperative and postoperative fracture imaging data of the patient: the left side is the preoperative imaging image of Fang XX's right wrist joint, and the right side is the postoperative imaging image of Fang XX's right wrist joint.

[0041] Treatment results: After one month of continuous external washing treatment, the swelling and pain in the patient's right wrist completely disappeared, and the range of motion of the wrist joint flexion, extension and rotation was significantly improved. Four months after the operation, the wrist joint function was basically restored and there was no obvious discomfort.

[0042] Example 5: Clinical Case of Postoperative Rehabilitation of Metacarpal Fractures Patient Cui XX, male, 20 years old, suffered a distal fracture of the right fifth metacarpal bone due to a fall in 2025. He underwent closed reduction and internal fixation with Kirschner wires to treat the fracture of the fifth metacarpal bone at our hospital. One month after the operation, a follow-up examination showed that the patient's right little finger had slightly limited flexion and extension, stiffness of the metacarpophalangeal joints, and incomplete fist clenching.

[0043] Treatment plan: Use the prepared lotion formula from Example 2 for external fumigation and washing treatment. Instructions: Take one packet of powder (20g), add 1000ml of cold water and soak for 30 minutes. Bring to a boil over high heat, then simmer over low heat for another 30 minutes. First, use the hot steam to fumigate the affected limb's palm. When the liquid temperature drops to around 40℃, immerse the affected limb's palm in the liquid. Each fumigation and washing session should last 30 minutes, twice a day, morning and evening. After fumigation and washing, perform finger flexion and extension, and fist clenching exercises.

[0044] like Figure 2 As shown, the relevant imaging data for this case are as follows: the left side is the preoperative imaging image of Cui XX's right hand, and the right side is the imaging image of Cui XX's right hand 3 months after surgery.

[0045] Treatment results: After two months of continuous treatment, the patient's right little finger flexion and extension range of motion improved significantly. At the follow-up examination three months after the operation, the finger function was fully restored, the fist could be clenched well, and there was no limitation of movement or pain or discomfort.

[0046] Example 6: Clinical Case of Postoperative Rehabilitation for Extensor Tendon Rupture Patient Xu XX, male, 53 years old, suffered a machine-related injury resulting in rupture of the extensor tendons of his right index and middle fingers. He underwent tendon suturing and plaster cast immobilization in our emergency department. The cast was removed three weeks post-surgery, and functional exercises were initiated. At a follow-up examination one month post-surgery, the patient's right middle finger extension was severely restricted, the metacarpophalangeal joint was stiff, and there was local swelling and pain.

[0047] Treatment plan: Use the ready-made lotion formula from Example 1 for external fumigation and washing treatment. Instructions: Take two packets (20g) of the powder, add 1000ml of cold water and soak for 30 minutes. Bring to a boil over high heat, then simmer over low heat for another 30 minutes. First, use the hot steam to fumigate the affected finger. When the liquid temperature drops to around 40℃, immerse the affected finger in the liquid. Each fumigation and washing session should last 30 minutes, twice a day, morning and evening. After fumigation and washing, perform finger extension exercises.

[0048] Treatment results: After one month of continuous treatment, the patient's right index and middle fingers showed significant improvement in extension, and the local swelling and pain disappeared; a follow-up examination three months after the operation showed no significant abnormalities in the flexion and extension functions of the right index and middle fingers, the tendons healed well, and there was no recurrence of adhesions.

[0049] Example 7: Clinical Case Study on Rehabilitation of Distal Radioulnar Joint Injury Patient Wang XX, female, 33 years old, presented to the hospital with pain and limited range of motion in her right wrist due to a fall while riding an electric scooter. An MRI confirmed a right distal radioulnar joint injury, and she was given conservative treatment with plaster cast immobilization. The cast was removed after 6 weeks, but the patient still experienced pain during right wrist rotation, wrist weakness, and limited forearm rotation.

[0050] Treatment plan: Use the prepared lotion formula from Example 3 for external fumigation and washing treatment. Instructions: Take one packet (15g) of powder, add 1000ml of cold water and soak for 30 minutes. Bring to a boil over high heat, then simmer over low heat for another 30 minutes. First, use the hot steam to fumigate the wrist of the affected limb. When the temperature of the liquid drops to around 40℃, immerse the wrist of the affected limb in the liquid. Each fumigation and washing session should last 30 minutes, twice a day, morning and evening. After fumigation and washing, perform wrist joint rotation and flexion / extension exercises.

[0051] like Figure 3 As shown, the relevant imaging data for this case are as follows: The left side shows the MRI image of Wang XX's right wrist joint before treatment, and the right side shows the follow-up image of Wang XX's right wrist joint after treatment.

[0052] Treatment results: After 6 weeks of continuous treatment, the patient's pain during right wrist rotation completely disappeared, and wrist joint strength was restored; a follow-up examination 2.5 months after the injury showed that the right wrist function had significantly improved, and there was no obvious pain during movement; a follow-up examination 3 months after the injury showed that there was no pain or restriction during wrist rotation, and joint function had fully recovered.

[0053] Example 8: Clinical Rehabilitation Case of Forearm Crush Injury with Radial Nerve Injury Patient Zhao XX, male, 28 years old, suffered a crush injury to his right forearm due to machinery, complicated by radial nerve injury and dorsal interosseous artery nerve injury in the right forearm. He underwent surgery in our hospital's emergency department. Postoperatively, the patient developed sequelae of radial nerve injury, with severely limited wrist dorsiflexion, weakness in the extension of all fingers of the right hand, and numbness in the forearm.

[0054] Treatment plan: Use the ready-made wash formula from Example 2 for external fumigation and washing treatment. Treatment begins one month post-surgery. The method of use is as follows: Take two packets of powder (40g), add 2000ml of cold water and soak for 30 minutes. After boiling over high heat, simmer over low heat for another 30 minutes. First, use the hot liquid to fumigate the right forearm and wrist. When the liquid temperature drops to about 40℃, immerse the right forearm in the liquid. Each fumigation and washing session lasts for a total of 30 minutes, once in the morning and once in the evening. After fumigation and washing, combine with wrist dorsiflexion and finger straightening exercises and neurotrophic therapy.

[0055] like Figure 4 As shown, after two months of continuous treatment, the patient's radial nerve injury sequelae improved significantly, the numbness in the forearm disappeared, and the strength of the wrist dorsiflexion muscle was significantly improved; a follow-up examination six months after the operation showed that the patient's right wrist dorsiflexion function had fully recovered to normal, there was no obvious limitation of movement in the fingers of the right hand, and the nerve function had basically recovered.

[0056] Based on the above applications, the upper limb wound washing formula provided by this invention is a traditional Chinese medicine compound. After the ingredients are combined, the entire formula has the effects of promoting blood circulation and reducing swelling, dispelling wind and unblocking meridians. It also exerts synergistic effects such as anti-inflammatory, antibacterial, analgesic, and circulation-improving effects. Compared with simple Western medicine anti-inflammatory and analgesic treatments, it can promote wound repair holistically. Secondly, the external treatment method of traditional Chinese medicine has unique advantages. Local fumigation and washing allows the effective components of the medicine to directly reach the affected area, resulting in high local concentrations and rapid onset of action, while avoiding the gastrointestinal irritation and systemic reactions associated with oral medications. Thirdly, for postoperative infections or inflammation, this method can serve as an effective adjunct or alternative, providing a solution with a low recurrence rate and few side effects. Finally, this method also has good safety and compliance, few adverse reactions, and is easy to operate, making it more acceptable to patients.

[0057] The above description is merely a specific embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any variations or substitutions that can be easily conceived by those skilled in the art within the technical scope disclosed in the present invention should be included within the scope of protection of the present invention. Therefore, the scope of protection of the present invention should be determined by the scope of the claims.

Claims

1. A lotion formula for treating fracture injuries, characterized in that, By mass parts, it includes the following traditional Chinese medicine raw material components: Lycopodium clavatum 80 - 100 parts; Speranskia tuberculata 80 - 100 parts; Schizonepeta tenuifolia 50 - 70 parts; Saposhnikovia divaricata 50 - 70 parts; Homalomena occulta 80 - 100 parts; Clematis chinensis 50 - 70 parts; Bombyx batryticatus 50 - 70 parts; Eupolyphaga sinensis 50 - 70 parts.

2. The lotion formula for treating fracture injuries according to claim 1, characterized in that, By mass parts, it includes the following traditional Chinese medicine raw material components: Lycopodium clavatum 90 parts; Speranskia tuberculata 90 parts; Schizonepeta tenuifolia 60 parts; Saposhnikovia divaricata 60 parts; Homalomena occulta 90 parts; Clematis chinensis 60 parts; Bombyx batryticatus 60 parts; Eupolyphaga sinensis 60 parts.

3. The lotion formulation for treating fracture injuries according to claim 1, characterized in that, The mass ratio of Lycopodium clavatum to Speranskia tuberculata is 1:

1.

4. The lotion formulation for treating fracture injuries according to claim 1, characterized in that, The mass ratio of Schizonepeta tenuifolia to Saposhnikovia divaricata is 1:

1.

5. The lotion formulation for treating fracture injuries according to claim 1, characterized in that, The mass ratio of Homalomena occulta to Clematis chinensis is (1.5 - 1.7):

1.

6. A method for preparing a lotion formulation for treating fracture injuries as described in any one of claims 1-5, characterized in that, It includes the following steps: Step 1: Pretreatment of medicinal materials. Lycopodium clavatum, Speranskia tuberculata, Schizonepeta tenuifolia, Saposhnikovia divaricata, Homalomena occulta, Clematis chinensis, Bombyx batryticatus, and Eupolyphaga sinensis are respectively subjected to impurity removal and non-medicinal part removal, and then dried at low temperature until the moisture content ≤ 8%. Step 2: Crushing and sieving. The dried medicinal materials are respectively crushed and passed through a 80 - 100 mesh standard sieve, and the fine powder under the sieve is collected. Step 3: Weighing and mixing. Weigh the fine powder of each medicinal material according to the prescription mass ratio, place it in a mixer and mix for 30 - 45 minutes until the color and luster of the material are uniform. [[ID=A]]Step 4: Sub-packaging and sterilization. The uniformly mixed medicinal powder is sub-packed into a sterile container and sealed, and then sterilized by ultraviolet irradiation for 30 minutes to obtain the finished powder.

7. The preparation method according to claim 6, characterized in that, The temperature of the low-temperature drying in Step 1 is 40 - 50 °C.

8. The preparation method according to claim 6, characterized in that, For the mixed material in Step 3, the relative standard deviation RSD of its mixing uniformity ≤ 2%.

9. The preparation method according to claim 6, characterized in that, The sub-packaging specification of the medicinal powder in Step 4 is 10 - 20 g per bag.

10. The lotion formulation for treating fracture injuries according to any one of claims 1-5, characterized in that, The usage method of the lotion formula is: for external use by fumigating and washing. Add the formula medicinal powder to cold water, soak and boil it. First, fumigate the affected area with the hot air of the medicinal liquid, and then soak the affected area after the medicinal liquid cools down. It should be noted that in the original text, there is an error in the item ID in the English translation of step 4. It should be instead of [[ID=A]]. The above translation has been corrected accordingly.

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