Asymmetric pentamethine cyanine compounds
By introducing asymmetric multi-carbon chain sulfonic acid groups or multi-carbon chain quaternary ammonium salts to the core structure of pentamethylcyanine dye, the self-quenching problem of pentamethylcyanine compounds was solved, the fluorescence quantum yield and water solubility were improved, and their application in the biomedical field was expanded.
CN122145367APending Publication Date: 2026-06-05BGI WUHAN +1
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- BGI WUHAN
- Filing Date
- 2024-12-04
- Publication Date
- 2026-06-05
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Figure CN122145367A_ABST
Abstract
The present application relates to the technical field of fluorescent dyes, in particular to an asymmetric pentamethine cyanine compound. The compound comprises a structure as shown in formula I. The compound provided by the present application has good water solubility, near-infrared absorption, high fluorescence quantum yield and good molar absorption coefficient, and can be used in nucleic acid labeling, DNA sequencing, cell imaging, protein labeling or specific recognition of amino acids.
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