An integrated bio-information sensing device detection system

Abstract

The application discloses an integrated biological information sensing device detection system, which comprises a double-layer integrated optical machine frame body with a longitudinal layered space arrangement configuration. The frame body comprises a displacement table supporting plate and an optical path system supporting plate arranged in parallel in space, wherein the optical path system supporting plate is located below the displacement table supporting plate. The displacement table supporting plate is used for carrying an actuator, and is provided with a multi-axis displacement table and a displacement table control system. The multi-axis displacement table is used for carrying a sensing substrate and is controlled by the displacement table control system to perform focal domain axial dynamic feedback compensation movement based on return signal strength feedback. The optical path system supporting plate is used for constructing an optical darkroom environment, and is integrated with a self-shielding folding excitation channel composed of a plurality of mounting clamping grooves with geometric tolerance constraints. The two are connected through a group of supporting columns to maintain the geometric stability of the frame. The application significantly improves the optical axis stability and detection signal-to-noise ratio of the system under complex working conditions.

Description

Technical Field

[0001] This invention relates to the fields of precision opto-mechatronics integrated manufacturing and bio-detection technology, specifically to an integrated bio-information sensing device detection system. This system achieves physical and mechanical separation between the motion execution end and the core sensing optical path through structured partitioning with vertical displacement. Furthermore, it achieves passive spatial pose precision locking of optical elements by utilizing an integrated positioning unit with geometrically limiting features. This system is suitable for high-sensitivity precision detection of molecular interaction characteristics in various complex environments. Background Technology

[0002] In the field of precision biochemical feature detection, capturing the signal response of the sensing substrate surface through optical means is the core path to achieving high-sensitivity detection. However, in the pursuit of compact structure, existing integrated detection devices often struggle to effectively balance the mutual interference between mechanical actuators and high-precision detection optical paths. Typically, the inertial loads and alternating mechanical stresses generated by the displacement mechanism responsible for performing the scanning task during high-speed movement directly act on the sensitive optical support end due to the lack of effective suppression structures with physical dimensions. This leads to unpredictable coaxiality drift of the optical axis, thereby reducing detection stability under complex operating conditions.

[0003] Furthermore, although the industry has attempted to introduce integrated manufacturing processes to simplify the cumbersome optical path adjustment procedures, polymer structural components are prone to microscopic creep misalignment due to limitations in material mechanical properties when bearing heavy loads on optical components over long periods. This can disrupt the geometrical conjugate correlation of the precision optical detection link. Meanwhile, within a limited physical space, overcoming manufacturing process deviations and achieving highly free-degree-of-freedom pose locking of multiple optical lenses and reflective devices without redundant adjustment components remains a major bottleneck restricting the industrial application of high signal-to-noise ratio portable detection platforms. Summary of the Invention

[0004] To address the challenges of optical axis stability being susceptible to interference from the load of the power actuator in bioinformatics detection missions, and the potential for material aging and structural evolution in an integrated body when bearing heavy-duty optical components, this invention provides an integrated bioinformatics sensing device detection system. This system aims to solve the defects of traditional detection platforms, such as structural redundancy, complex optical path alignment, and difficulty in resisting dynamic stress disturbances, through a vertically stacked physical partition layout and an inherent slot-type design. This enables the capture of biochemical signals with high sensitivity and high geometric determinism under complex working conditions.

[0005] To solve the above-mentioned technical problems, the technical solution adopted by the present invention is as follows: In a first aspect, the present invention provides an integrated bio-information sensing device detection system, the detection system comprising a double-layer integrated optomechanical frame body having a longitudinally layered spatial arrangement configuration, the frame body comprising a displacement stage support plate and an optical path system support plate arranged in parallel in space, wherein the optical path system support plate is located below the displacement stage support plate; The displacement stage support plate is used to support the actuator. It is equipped with a multi-axis displacement stage and a displacement stage control system. The multi-axis displacement stage is used to support the sensing substrate and is controlled by the displacement stage control system to perform dynamic feedback compensation movement of the focal region axis based on the feedback of the return signal strength. The optical path system support plate is used to construct the optical darkroom environment. It integrates a self-shielded folded excitation path consisting of multiple mounting slots with dimensional and positional tolerance constraints. The displacement stage support plate and the optical path system support plate are connected by a set of support columns to maintain the load-bearing skeleton and ensure the geometric stability of the frame.

[0006] Following the above technical solution, the main frame also includes a mounting base plate at the bottom layer; the support column is made of a hard metal material with high mechanical modulus, runs longitudinally through the support column mounting groove opened on the displacement stage support plate, and extends downward and is anchored to the mounting base plate, so as to transmit the torque generated by the load element on the displacement stage support plate to its geometric axis, so as to counteract the alternating mechanical stress generated by the multi-axis displacement stage and maintain the coaxiality of the optical axis of the self-shielded folding excitation path on the optical path system support plate.

[0007] Following the above technical solution, the mounting base plate is provided with multiple countersunk holes for rigid locking of fastening screws. The optical slot modules on the optical path system support plate are rigidly integrated with the mounting base plate by fastening screws, ensuring the geometric stability of the overall frame.

[0008] Following the above technical solution, the main frame also includes front and rear mounting plates arranged at the front and rear, and light-absorbing plates distributed on opposite sides, which together with the displacement stage support plate and the optical path system support plate constitute an optical darkroom environment.

[0009] According to the above technical solution, the preset functional area of ​​the displacement stage support plate is surrounded by a light-absorbing plate and a wiring light-absorbing plate, and the top is provided with an end cap. The upper part of the light-absorbing plate and the wiring light-absorbing plate is provided with an end cap limiting block that matches the edge of the end cap. The multi-axis displacement stage and the displacement stage control system are built into the preset functional area. The light-absorbing board has vertically penetrating signal lead holes for guiding the internal cables of the displacement stage control system to the outside of the frame body, enabling physical interconnection and communication with the external data processing and analysis terminal; the upper surface of the displacement stage support plate is an open operating platform for directly supporting the external data processing and analysis terminal.

[0010] According to the above technical solution, the self-shielded folding excitation path is arranged in sequence along the energy vector transfer direction as follows: laser emitter mounting slot, optical fiber path, half-wave plate mounting slot, lens mounting slot, first lens bending device mounting slot, second lens bending device mounting slot, cemented doublet lens mounting slot, and camera mounting slot; the first lens bending device mounting slot and the second lens bending device mounting slot are equipped with lens bending devices, and respectively set with a dichroic beam splitter and a plane mirror; The detection system also includes an objective lens. The displacement stage support plate has a light-transmitting hole, and the objective lens is set accordingly. The principal optical axis of the objective lens coincides with the vertical optical axis of the lens turning device in physical space. The probe light is emitted by the laser emitter in the laser emitter mounting slot, and then passes sequentially through the optical fiber path, the half-wave plate in the half-wave plate mounting slot, the lens in the lens mounting slot, the dichroic beam splitter in the first lens bending device mounting slot, and then deflected to a vertical direction by the plane mirror in the second lens bending device mounting slot before entering the objective lens. The objective lens then directs the light onto the sensing substrate mounted on the multi-axis displacement stage, generating a return signal carrying biological interaction information of the sample. The return signal is reflected sequentially by the objective lens and the plane mirror in the second lens bending device mounting slot to the dichroic beam splitter in the first lens bending device mounting slot. After being reflected by the dichroic beam splitter, the light passes through the cemented doublet lens in the cemented doublet mounting slot and enters the sensor photosensitive surface in the camera mounting slot.

[0011] According to the above technical solution, the objective lens is spatially positioned and suspended by the objective lens cage plate and the matching objective lens cage rod. The top and root of the objective lens cage rod are respectively inserted into and fixed in the cage rod mounting holes opened on the displacement stage support plate and the optical path system support plate.

[0012] Following the above technical solution, a power supply mounting slot is provided in the enclosed space on the right side of the optical path system support plate for accommodating the power supply and logic control module of the detection system.

[0013] Following the above technical solution, the inner wall of each mounting slot adopts an adaptive geometric alignment structure. An endogenous limiting groove ridge with a micro-elastic modulus is formed in the slot using additive manufacturing process. The spatial six-degree-of-freedom coordinates of the internal optical components are locked through tight tolerance clearance.

[0014] In a second aspect, the present invention provides an integrated bio-information sensing device, including the integrated bio-information sensing device detection system described in the first aspect.

[0015] In summary, compared with the prior art, the above-described technical solutions conceived by this invention can achieve the following beneficial effects: This invention achieves physical and mechanical separation between the power actuator and the core sensing optical path through a structured partitioning design with vertical displacement, significantly improving the system's optical axis coaxiality retention under dynamic scanning conditions. Secondly, utilizing endogenous limiting grooves with micro-elastic characteristics, the system achieves passive spatial pose locking of optical elements, greatly simplifying the construction process of high-precision optical paths and reducing reliance on discrete precision adjustment components. Furthermore, the rigid load-bearing skeleton constructed with hard metal support columns effectively suppresses geometric deviations caused by the aging of additive manufacturing materials, ensuring long-term geometric stability during biochemical tracing. Finally, combining a closed design with light-absorbing textures, this system constructs a high-quality detection darkroom within a compact physical space, significantly improving the signal-to-noise ratio for capturing weak biological interaction signals. Attached Figure Description

[0016] Figure 1 This is an external structural diagram of an integrated bio-information sensing device detection system according to an embodiment of the present invention; Figure 2 This is a schematic diagram of the optical path of an integrated bio-information sensing device detection system according to an embodiment of the present invention; Figure 3 This is a structural diagram of a displacement stage control system according to an embodiment of the present invention; Figure 4 This is a schematic diagram of a vertical fixing structure according to an embodiment of the present invention; Figure 5 This is a structural diagram of an optical path card slot system according to an embodiment of the present invention; Figure 6 This is a structural diagram of a lens turning device according to an embodiment of the present invention.

[0017] In the diagram: 1. Stage control system; 2. Front and rear mounting plates; 3. Stage support plate; 4. Optical path system support plate; 5. Mounting base plate; 6. Objective lens cage rod; 7. Lens reversing device; 8. Camera mounting slot; 9. Fastening screw; 10. Support column; 11. End cap; 12. End cap limit block; 13. Light-absorbing plate; 14. Cage rod mounting hole; 15. Multi-axis stage; 16. Cable-guided light-absorbing plate; 17. End cap handle; 18. Objective lens; 19. Objective lens cage plate; 20. Support column mounting slot; 21. Fastening screw mounting countersunk hole; 22. Laser emitter mounting slot; 23. Power supply mounting slot; 24. Half-wave plate mounting slot; 25. Lens mounting slot; 26. Lens reversing device mounting slot; 27. Cemented doublet lens mounting slot; 71. Lens mounting slot; 72. Light passage hole. Detailed Implementation

[0018] To make the objectives, technical solutions, and advantages of this invention clearer, the invention will be further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative and not intended to limit the invention. All other embodiments obtained by those skilled in the art based on the embodiments provided by this invention without inventive effort are within the scope of protection of this invention.

[0019] Obviously, the accompanying drawings described below are merely some examples or embodiments of the present invention. Those skilled in the art can apply the present invention to other similar scenarios based on these drawings without any inventive effort. Furthermore, it is understood that although the efforts made in this development process may be complex and lengthy, for those skilled in the art related to the content disclosed in this invention, modifications to design, manufacturing, or production based on the technical content disclosed in this invention are merely conventional technical means and should not be construed as insufficient disclosure of the present invention.

[0020] In this invention, the reference to "embodiment" means that a specific feature, structure, or characteristic described in connection with an embodiment may be included in at least one embodiment of the invention. The appearance of this phrase in various places in the specification does not necessarily refer to the same embodiment, nor is it a mutually exclusive, independent, or alternative embodiment. It will be explicitly and implicitly understood by those skilled in the art that the embodiments described in this invention may be combined with other embodiments without conflict.

[0021] Unless otherwise defined, the technical or scientific terms used in this invention shall have the ordinary meaning understood by one of ordinary skill in the art to which this invention pertains. The terms "a," "an," "an," "the," and similar words used in this invention do not indicate quantity limitation and may indicate singular or plural. The terms "comprising," "including," "having," and any variations thereof used in this invention are intended to cover non-exclusive inclusion; for example, a process, method, system, product, or device that includes a series of steps or modules (units) is not limited to the listed steps or units, but may also include steps or units not listed, or may include other steps or units inherent to these processes, methods, products, or devices. The terms "connected," "linked," "coupled," and similar words used in this invention are not limited to physical or mechanical connections, but may include electrical connections, whether direct or indirect. "A plurality" used in this invention refers to two or more. "And / or" describes the relationship between related objects, indicating that three relationships may exist; for example, "A and / or B" can represent: A alone, A and B simultaneously, and B alone. The character " / " generally indicates that the preceding and following objects have an "or" relationship. The terms "first," "second," and "third" used in this invention are merely to distinguish similar objects and do not represent a specific ordering of the objects.

[0022] This invention provides an integrated bio-information sensing device detection system. The system employs a vertically layered, dual-layer integrated precision optomechanical frame, consisting of a spatially parallel displacement stage support plate and a lower optical path system support plate. These two components are supported by high-modulus pillars to maintain spatial geometric stability. The upper surface of the displacement stage support plate houses a displacement stage control system and a multi-axis displacement stage, used to support a sensing substrate with periodic waveguide mode resonance characteristics and perform axial focal domain dynamic feedback compensation movement based on backhaul signal strength feedback. The upper surface of the displacement stage support plate serves as an open operating platform, directly supporting an external data processing and analysis terminal. The upper surface of the optical path system support plate integrates a self-shielded folded excitation path composed of a laser emitter, a half-wave plate, a collimating lens, a dichroic beam splitter, a plane mirror, and a lens deflection device. A power supply and logic control module are housed within a closed space on the right side of the optical path system support plate to achieve physical isolation between the energy hub and the precision optical detection link. Furthermore, the displacement stage support plate is equipped with a light-absorbing plate with wiring, utilizing its internal through-holes for signal leads to achieve cross-layer interconnection between the electrical sensing unit and the data processing and analysis terminal. Through ingenious spatial isolation layout and design, this invention achieves a compact structure while significantly improving the optical axis stability and detection signal-to-noise ratio of the system under complex operating conditions.

[0023] like Figure 1As shown, the integrated bioinformatics sensing device detection system of the present invention includes a dual-layer integrated precision optomechanical frame body with a longitudinally layered spatial arrangement. The frame body consists of a displacement stage support plate 3 arranged in parallel space to support the actuator, and an optical path system support plate 4 located below it to construct an optical darkroom environment. A multi-axis displacement stage 15 and a displacement stage control system 1 are mounted on the upper surface of the displacement stage support plate 3. The multi-axis displacement stage 15 is configured to support a sensing substrate with periodic waveguide mode resonance characteristics and is controlled by the displacement stage control system 1 to perform dynamic feedback compensation movement of the focal region axis based on the return signal intensity feedback. A self-shielded folded excitation path composed of multiple mounting slots with dimensional and positional tolerance constraints is integrated on the upper surface of the optical path system support plate 4, and a power supply mounting slot 23 is opened in the closed space on the right side of the optical path system support plate 4 for housing the power supply and logic control hub of the detection system. The preset functional area of ​​the displacement stage support plate 3 is equipped with a wiring light-absorbing plate 16. The center area of ​​the wiring light-absorbing plate 16 has a vertically penetrating signal lead through hole, which is used to guide the internal electrical sensing unit and drive unit cables to the outside of the frame body and realize physical interconnection and communication with the data processing and analysis terminal.

[0024] It should be noted that the data processing and analysis terminal can be a computer or the like, and the multi-axis displacement stage is controlled by the displacement stage control system to achieve dynamic feedback compensation movement of the focal domain axis based on the feedback of the return signal strength.

[0025] like Figure 1 and Figure 4 As shown, the displacement stage support plate 3 and the optical path system support plate 4 are connected by a set of support columns 10 with high mechanical modulus for stress-bearing skeleton. The support columns 10 extend longitudinally through the support column mounting groove 20 opened on the displacement stage support plate 3 and extend downward to be anchored to the mounting base plate 5. The rigid structure of the support columns 10 is configured to transmit the torque generated by the heavy load components to its axis to counteract the alternating mechanical stress generated by the multi-axis displacement stage 15 when performing large-area field image stitching scanning movement, and ensure that the coaxiality of the optical axis of the bottom folding excitation path does not drift due to the inertial load of the top layer.

[0026] like Figure 1 As shown, the enclosed space where the optical path system support plate 4 is located is edge-sealed by the front and rear mounting plates 2, and is provided with light-absorbing plates 13 distributed on opposite sides. The surface of the light-absorbing plate 13 is provided with micron-level scattering suppression texture to absorb parasitic stray light in the optical path system, thereby constructing a dark room detection space independent of external ambient light interference, which aims to improve the signal-to-noise ratio of the probe signal captured by the local field enhancement response on the sensing substrate surface.

[0027] like Figure 2 and Figure 5As shown, the self-shielded folded excitation path sequentially integrates the following components along the energy vector transfer direction: a laser emitter mounting slot 22, an optical fiber path for guiding coherent energy, a half-wave plate mounting slot 24, a lens mounting slot 25, a first lens bending device mounting slot, a cemented doublet lens mounting slot 27, a camera mounting slot 8, and a second lens bending device mounting slot for guiding beam steering. The inner walls of each mounting slot employ an adaptive geometric alignment structure, utilizing an endogenous limiting groove ridge with a micro-elastic modulus formed by additive manufacturing processes. This achieves spatial six-degree-of-freedom coordinate locking of the internal optical elements through tight tolerance clearance. A half-wave plate assembly is installed within the half-wave plate mounting slot 24, configured to define the initial polarization state vector rotation of the energy field output from the optical fiber path, matching its polarization direction with the dielectric structure mode at the bottom of the sensing substrate.

[0028] A lens reversing device 7 is installed within the lens reversing device mounting slot 26. The lens reversing device 7 in the first lens reversing device mounting slot has a dichroic beam splitter with spectrally selective transmission characteristics installed at an angle inside. This beam splitter is configured to allow light energy in the excitation band to pass through and enter the subsequent reversing optical path, while simultaneously reflecting the return coherent signal carrying sample biological interaction information to the photosensitive surface of the image sensor inside the camera mounting slot 8. The lens reversing device 7 in the second lens reversing device mounting slot contains a plane mirror with an inclination angle precisely defined at 45 degrees by the geometric tolerance of the lens mounting slot 71. Figure 6 As shown, the collimated beam after shaping is guided through the light-transmitting hole 72 of the lens turning device 7 vertically through the light-transmitting hole located at the center of the displacement stage support plate 3, thereby forming a locally enhanced energy-sensitive field distribution area on the surface of the sensing substrate.

[0029] like Figure 3 and Figure 4 As shown, the detection system also includes an objective lens 18 located above the vertical projection of the light-transmitting aperture 72 of the lens turning device 7. The objective lens 18 is spatially positioned and suspended by the objective lens cage plate 19 and its matching objective lens cage rod 6. The top of the objective lens cage rod 6 is inserted into and fixed in the cage rod mounting hole on the displacement stage support plate 3, and its root is inserted into and fixed in the cage rod mounting hole 14 on the optical path system support plate 4, ensuring that the principal optical axis of the objective lens 18 coincides with the vertical optical axis from the lens turning device 7 in physical space.

[0030] like Figure 2As shown, the probe light is emitted by the laser emitter in the laser emitter mounting slot 22, and then passes sequentially through the optical fiber path, the half-wave plate in the half-wave plate mounting slot 24, the lens in the lens mounting slot 25, the dichroic beam splitter in the first lens bending device mounting slot, and then deflected to the vertical direction by the plane mirror in the second lens bending device mounting slot and enters the objective lens 18. The objective lens then directs the light onto the sensing substrate mounted on the multi-axis displacement stage 15, generating a return signal carrying the biological interaction information of the sample. The return signal is reflected sequentially by the objective lens 18 and the plane mirror in the second lens bending device mounting slot to the dichroic beam splitter in the first lens bending device mounting slot. After being reflected by the dichroic beam splitter, the light passes through the cemented doublet lens in the cemented doublet mounting slot 27 and enters the sensor photosensitive surface in the camera mounting slot 8.

[0031] like Figure 3 As shown, the external part of the displacement stage control system 1 is provided with a physical protective barrier consisting of the displacement stage control system end cover 11 and the end cover limiting block 12 matching its edge. One side of the displacement stage control system end cover 11 is provided with an end cover handle 17 to facilitate manual pull-out maintenance of the internal actuator circuit. At the same time, multiple fastening screw mounting countersunk holes 21 for rigid locking are opened on the mounting base plate 5. The various optical card slot modules of the bottom layer and the optical path system support plate 4 are formed into a rigid whole by fastening screws 9.

[0032] As described above, the integrated bioinformatics sensing device detection system of the present invention comprises a core architecture consisting of a dual-layer integrated precision optomechanical frame with a vertically layered spatial arrangement. This frame consists of a displacement stage support plate arranged in parallel space to support the power actuator, and an optical path system support plate located below it to construct the optical darkroom detection environment. On the upper surface of the displacement stage support plate, the system integrates a multi-axis displacement stage and a displacement stage control system, used to support a sensing substrate with periodic waveguide mode resonance characteristics, and capable of performing dynamic feedback compensation movement of the focal region axial direction based on the return signal strength feedback. Furthermore, the support plate has a pre-set functional area with a light-absorbing plate for wiring, utilizing its internal through-holes for signal leads to achieve cross-layer physical link interconnection between the internal electrical sensing unit and drive cables and the external data processing and analysis terminal.

[0033] The lower-level optical path system support plate integrates a self-shielded folded excitation path composed of multiple mounting slots with dimensional and positional tolerance constraints. Along the energy vector transfer direction, this path sequentially integrates core components such as a laser emitter mounting slot, fiber optic path, half-wave plate mounting slot, lens mounting slot, first lens bending device mounting slot, second lens bending device mounting slot, cemented doublet lens mounting slot, and camera mounting slot. The inner walls of these mounting slots employ an adaptive geometric alignment structure, using additive manufacturing processes to create endogenous limiting ridges with a low elastic modulus. These ridges directly lock the six-degree-of-freedom spatial coordinates of the internal optical components using tight tolerances, thus avoiding random errors introduced by manual assembly. To ensure that the underlying precision optical link is not interfered with by the top-level power source, the displacement stage support plate and the optical path system support plate are connected by a set of support columns with high mechanical modulus to form a load-bearing framework. The support column runs longitudinally through and is anchored to the mounting base plate. Its rigid structure can guide the torque generated by the heavy-load components to the axis, effectively offsetting the alternating mechanical stress generated by the multi-axis displacement stage when performing large-area scanning movement, and preventing optical axis offset caused by material aging deformation.

[0034] In terms of ensuring optical detection performance, the enclosed space containing the optical path system is edge-sealed by front and rear mounting plates and equipped with a light-absorbing plate with micron-level scattering suppression texture on its surface to absorb parasitic stray light and create a darkroom space independent of external environmental interference. The system guides the beam vertically through the light-transmitting aperture at the center of the displacement stage support plate via a precisely defined plane mirror inside the lens deflection device, forming a locally enhanced energy-sensitive field on the sensing substrate surface. Simultaneously, the objective lens, positioned above the vertical projection of the light-transmitting aperture, is suspended and positioned by a cage system, ensuring that its principal optical axis coincides with the vertical excitation optical axis in physical space. The signal carrying sample interaction information is spectrally selectively separated by a dichroic beam splitter, allowing the return signal to be accurately reflected to the sensor's photosensitive surface within the camera mounting slot. Furthermore, a power supply mounting slot is located within the enclosed space on the right side of the optical path system support plate, achieving physical separation between the energy supply hub and the precision optical detection link. The displacement stage control system is also externally protected by a physical barrier consisting of end caps and limiting blocks, and each optical slot module is rigidly integrated with the support plate using fastening screws.

[0035] Through a structured partitioning design with vertical displacement, this detection system achieves physical and mechanical separation between the power actuator and the core sensing optical path, significantly improving the system's optical axis coaxiality retention under dynamic scanning conditions. Secondly, utilizing endogenous limiting grooves with micro-elastic characteristics, the system achieves passive spatial pose locking of optical elements, greatly simplifying the construction process of high-precision optical paths and reducing reliance on discrete precision adjustment components. Furthermore, the rigid load-bearing skeleton constructed with hard metal support columns effectively suppresses geometric deviations caused by the aging of additive manufacturing materials, ensuring long-term geometric stability during biochemical tracing. Finally, combining a closed design with light-absorbing textures, this system constructs a high-quality detection darkroom within a compact physical space, significantly improving the signal-to-noise ratio for capturing weak biological interaction signals.

[0036] In addition, the present invention also provides an integrated bio-information sensing device, which includes the aforementioned integrated bio-information sensing device detection system. For example... Figures 1 to 6 As shown, the physical architecture of this detection system is based on a vertically layered modular design, including a dual-layered integrated precision optomechanical frame with a vertically layered spatial arrangement. This frame consists of a displacement stage support plate 3 arranged in parallel space and an optical path system support plate 4 located below it. This spatial layout physically isolates the mechanical power components performing the scanning task from the optical links responsible for precision sensing. The displacement stage support plate 3 serves as an open operating platform, supporting the power actuators and providing physical support for the external data processing and analysis terminal. The optical path system support plate 4 is configured to create an optical anechoic chamber environment, protecting the internal detection optical path from interference from external ambient light.

[0037] In the mechanically supported structure, the displacement stage support plate 3 and the optical path system support plate 4 are connected by a set of support columns 10. These support columns 10 are made of a high-mechanical-modulus hard metal material, extending longitudinally through a support column mounting groove 20 on the displacement stage support plate 3, and downwards to be anchored to the bottom mounting base plate 5. The rigid structure of the support columns 10 is configured to transmit the torsional torque generated by the load elements on the displacement stage support plate 3 to its geometric axis, thereby counteracting the alternating mechanical stress generated by the multi-axis displacement stage 15 during large-area field scanning or frequent start-stop operations. Through this stress transmission path, the system can prevent coaxiality drift of the optical axis of the bottom-layer folded excitation path due to the material aging and structural evolution that may occur when the additive manufacturing material bears heavy loads. On the mounting base plate 5, the system has multiple countersunk holes 21 for rigid locking screws. These screws 9 form a rigid integral connection between the optical slot modules on the optical path system support plate 4 and the base plate, thus ensuring the geometric stability of the overall frame.

[0038] The arrangement of the displacement stage support plate 3 is as follows: Figure 1 and Figure 3 As shown, a multi-axis displacement stage 15 and a displacement stage control system 1 are mounted on its upper surface. The multi-axis displacement stage 15 is configured to support a sensing substrate with periodic waveguide mode resonance characteristics and performs dynamic axial compensation movement of the focal region based on feedback of the return signal strength under the command of the displacement stage control system 1. In order to achieve a regularized cable layout and suppress parasitic stray light, a cable light-absorbing plate 16 is installed in the preset functional area of ​​the displacement stage support plate 3. A vertically penetrating signal lead through hole is opened in the central area of ​​the cable light-absorbing plate 16. This through hole is configured to guide the cables of the internal electrical sensing units such as cameras and motors and drive units to the outside of the frame body to achieve physical connection with the data processing and analysis terminal. The displacement stage control system 1 is provided with a physical protective barrier consisting of the displacement stage control system end cover 11 and the end cover limiting block 12 on its edge. An end cover handle 17 is provided on one side of the end cover 11 to support manual pull-out maintenance of the internal circuit and substrate.

[0039] The optical path system support plate 4 integrates a self-shielded folded excitation path, the structural details of which are as follows: Figure 5 As shown, the pathway, arranged sequentially along the energy vector transfer direction, includes: a laser emitter mounting slot 22, an optical fiber path for guiding coherent energy, a half-wave plate mounting slot 24, a lens mounting slot 25, a first lens reversing device mounting slot, a second lens reversing device mounting slot, a cemented doublet lens mounting slot 27, and a camera mounting slot 8. The inner walls of all the aforementioned mounting slots employ an adaptive geometric alignment structure. Specifically, this structure utilizes an additive manufacturing process to create an endogenous limiting ridge with a micro-elastic modulus within the slot, achieving spatial six-degree-of-freedom coordinate locking of the internal optical elements through tight tolerance clearance. This passive pose locking mechanism replaces the traditional manual optical path adjustment process, directly transforming the centrality and coaxiality of the optical elements into the geometric properties of the camera body.

[0040] In the modulation sequence of the excitation optical path, a half-wave plate assembly is placed in the half-wave plate mounting slot 24. This assembly is configured to define the initial polarization state vector rotation of the coherent energy field output from the optical fiber path, matching its polarization direction with the dielectric structure mode at the bottom of the sensing substrate, thereby optimizing the excitation efficiency of the guided mode resonance effect. The enclosed space where the optical path system support plate 4 is located is physically sealed by the front and rear mounting plates 2, and equipped with a light-absorbing plate 13 with a micron-level scattering suppression texture on its surface. The light-absorbing plate 13 is configured to absorb parasitic stray light inside the system, thereby constructing a dark chamber detection space independent of external ambient light. Inside the conversion mirror and dichroic mirror mounting slot 71, a dichroic beam splitter with spectrally selective transmission characteristics is installed at an angle. This beam splitter is configured to allow light energy in the excitation band to pass through and enter the subsequent conversion optical path, while reflecting the return signal carrying sample biological interaction information to the photosensitive surface of the image sensor inside the camera mounting slot 8.

[0041] The vertical deflection of the optical path is achieved through the lens deflection device 7. For example... Figure 6 As shown, a lens reversing device 7 is anchored inside the lens reversing device mounting groove 26, and a plane mirror with an inclination angle limited to 45 degrees by the geometric tolerance of the mounting groove is provided inside. This plane mirror is used to guide the shaped collimated beam vertically upward through the light-transmitting hole located at the center of the displacement stage support plate 3, thereby forming a locally enhanced energy-sensitive field distribution area on the sensing substrate surface. Above the vertical projection of the light-transmitting hole, the system provides an objective lens 18, which is spatially positioned and suspended by an objective lens cage plate 19 and a matching objective lens cage rod 6. The root of the objective lens cage rod 6 is inserted into and fixed in the cage rod mounting hole 14 on the optical path system support plate 4, and its geometric relationship ensures that the principal optical axis of the objective lens 18 coincides with the vertical excitation optical axis from the lens reversing device 7 in physical space.

[0042] In the energy management and logic control structure, a power supply mounting slot 23 is provided in the enclosed space on the right side of the optical path system support plate 4, for housing the energy supply hub and logic control module of the detection system. This physical isolation design decouples the power supply from the precision optical detection link, reducing the impact of thermal effects or electromagnetic interference on detection accuracy. Through the aforementioned spatial geometric relationships and mechanical constraints, the various components of the entire system form an integrated biochemical sensing platform with structural self-compensation capabilities, maintaining a high detection signal-to-noise ratio and optical axis stability without relying on traditional heavy mechanical components.

[0043] In the actual assembly process, each optical element is pressed into its corresponding mounting slot, and the micro-elastic modulus of the slot ridge is used to achieve force anchoring. The signal captured by the imaging feedback link is converted into digital information by the sensor in the camera mounting slot 8. The displacement stage control system 1 drives the multi-axis displacement stage 15 to adjust the position of the sensing substrate according to the signal characteristics, thereby achieving a closed-loop detection feedback logic. Through this comprehensive approach of precision slot limitation, layered architecture isolation, and rigid frame reinforcement, the system solves the problem of optical axis misalignment caused by structural deformation of the body under high load.

[0044] During the construction of this system, the integral molding characteristics of additive manufacturing are utilized to integrate the functions of traditional discrete cage rods or guide rails into the intrinsic structure of the frame body. The spatial tolerance between the laser emitter mounting slot 22 and the half-wave plate mounting slot 24 and lens mounting slot 25 is directly limited by the geometric accuracy of the printing process, and the optical axes achieve the preset coaxiality requirements after static assembly. The objective lens cage rod 6 maintains the stable pose of the objective lens 18 in three-dimensional space through the cantilever support force provided by the cage rod mounting hole 14, enabling it to collect signals from the sensing substrate surface in real time. In addition, the surface texture configuration of the wiring light-absorbing plate 16 is designed to further consume incoherent photons generated by multiple reflections within the system, thereby improving the resolution purity of the local field enhancement response signal.

[0045] In summary, the detection system of this sensing device, through the parallel arrangement of the displacement stage support plate 3 and the optical path system support plate 4, utilizes the torque transmission characteristics of the support column 10 and is supplemented by the component locking capability of the adaptive geometric alignment structure, to construct a precision detection environment with physical isolation characteristics within a compact volume, which is suitable for portable biochemical tracing tasks.

[0046] It should be noted that, depending on the implementation needs, the various steps / components described in this invention can be broken down into more steps / components, or two or more steps / components or parts of the operation of steps / components can be combined into new steps / components to achieve the purpose of this invention.

[0047] Those skilled in the art will readily understand that the above are merely preferred embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of the present invention should be included within the scope of protection of the present invention.

Claims

1. An integrated bio-information sensing device detection system, characterized in that, The detection system includes a dual-layer integrated optomechanical frame body with a longitudinally layered spatial arrangement. The frame body includes a displacement stage support plate and an optical path system support plate arranged in parallel in space, wherein the optical path system support plate is located below the displacement stage support plate. The displacement stage support plate is used to support the actuator. It is equipped with a multi-axis displacement stage and a displacement stage control system. The multi-axis displacement stage is used to support the sensing substrate and is controlled by the displacement stage control system to perform dynamic feedback compensation movement of the focal region axis based on the feedback of the return signal strength. The optical path system support plate is used to construct the optical darkroom environment. It integrates a self-shielded folded excitation path consisting of multiple mounting slots with dimensional and positional tolerance constraints. The displacement stage support plate and the optical path system support plate are connected by a set of support columns to maintain the load-bearing skeleton and ensure the geometric stability of the frame.

2. The integrated bio-information sensing device detection system according to claim 1, characterized in that, The main frame also includes a mounting base plate at the bottom layer; the support column is made of a hard metal material with high mechanical modulus, and extends longitudinally through the support column mounting groove opened on the displacement stage support plate, and extends downward and is anchored to the mounting base plate, so as to transmit the torque generated by the load element on the displacement stage support plate to its geometric axis, so as to counteract the alternating mechanical stress generated by the multi-axis displacement stage and maintain the coaxiality of the optical axis of the self-shielded folding excitation path on the optical path system support plate.

3. The integrated bio-information sensing device detection system according to claim 2, characterized in that, The mounting base plate has multiple countersunk holes for rigid locking screws. The optical slot modules on the optical path system support plate are rigidly integrated with the mounting base plate by the locking screws, ensuring the geometric stability of the overall frame.

4. The integrated bio-information sensing device detection system according to claim 1, characterized in that, The main frame also includes front and rear mounting plates and light-absorbing plates distributed on opposite sides, which together with the displacement stage support plate and the optical path system support plate constitute an optical darkroom environment.

5. The integrated bio-information sensing device detection system according to claim 1, characterized in that, The preset functional area of ​​the displacement stage support plate is surrounded by a light-absorbing plate and a wiring light-absorbing plate, and the top is provided with an end cap. The upper part of the light-absorbing plate and the wiring light-absorbing plate is provided with an end cap limiting block that matches the edge of the end cap. The multi-axis displacement stage and the displacement stage control system are built into the preset functional area. The light-absorbing board has vertically penetrating signal lead holes for guiding the internal cables of the displacement stage control system to the outside of the frame body, enabling physical interconnection and communication with the external data processing and analysis terminal; the upper surface of the displacement stage support plate is an open operating platform for directly supporting the external data processing and analysis terminal.

6. The integrated bio-information sensing device detection system according to claim 2, characterized in that, The self-shielded folding excitation path is arranged along the energy vector transmission direction with a laser emitter mounting slot, an optical fiber path, a half-wave plate mounting slot, a lens mounting slot, a first lens bending device mounting slot, a second lens bending device mounting slot, a cemented doublet lens mounting slot, and a camera mounting slot. The first lens bending device mounting slot and the second lens bending device mounting slot are equipped with lens bending devices, and a dichroic beam splitter and a plane mirror are respectively installed. The detection system also includes an objective lens. The displacement stage support plate has a light-transmitting hole, and the objective lens is set accordingly. The principal optical axis of the objective lens coincides with the vertical optical axis of the lens turning device in physical space. The probe light is emitted by the laser emitter in the laser emitter mounting slot, and then passes sequentially through the optical fiber path, the half-wave plate in the half-wave plate mounting slot, the lens in the lens mounting slot, the dichroic beam splitter in the first lens bending device mounting slot, and then deflected to a vertical direction by the plane mirror in the second lens bending device mounting slot before entering the objective lens. The objective lens then directs the light onto the sensing substrate mounted on the multi-axis displacement stage, generating a return signal carrying biological interaction information of the sample. The return signal is reflected sequentially by the objective lens and the plane mirror in the second lens bending device mounting slot to the dichroic beam splitter in the first lens bending device mounting slot. After being reflected by the dichroic beam splitter, the light passes through the cemented doublet lens in the cemented doublet mounting slot and enters the sensor photosensitive surface in the camera mounting slot.

7. The integrated bio-information sensing device detection system according to claim 6, characterized in that, The objective lens is spatially positioned and suspended by an objective lens cage plate and a matching objective lens cage rod. The top and root of the objective lens cage rod are respectively inserted into and fixed in the cage rod mounting holes opened on the displacement stage support plate and the optical path system support plate.

8. The integrated bio-information sensing device detection system according to claim 6, characterized in that, A power supply mounting slot is provided in the enclosed space on the right side of the optical path system support plate for housing the power supply and logic control module of the detection system.

9. The integrated bio-information sensing device detection system according to any one of claims 6 to 8, characterized in that, The inner wall of each mounting slot adopts an adaptive geometric alignment structure. An endogenous limiting groove ridge with a micro-elastic modulus is formed in the slot using additive manufacturing process. The spatial six-degree-of-freedom coordinate locking of the internal optical components is achieved through tight tolerance clearance.

10. An integrated bio-information sensing device, characterized in that, The detection system includes the integrated bio-information sensing device according to any one of claims 1 to 9.

Images