Integrated intervention decision system of traditional Chinese and western medicine

Abstract

The present disclosure relates to the field of computer technology, and provides a traditional Chinese and Western medicine comprehensive intervention decision system, comprising a data acquisition module; a diagnosis reasoning module, configured to obtain analyzed traditional Chinese medicine syndrome information and analyzed Western medicine disease information according to traditional Chinese medicine and analyzed Western medicine physiological state data, and obtain traditional Chinese and Western medicine comprehensive diagnosis information; a multi-omics mapping module, configured to map pathological mechanism information according to the analyzed traditional Chinese medicine syndrome information; a fusion network module, configured to construct / call a fusion biological network corresponding to each preset traditional Chinese and Western medicine comprehensive diagnosis information; and an intervention decision module, configured to determine a recommended traditional Chinese and Western medicine comprehensive intervention scheme in an intervention scheme group associated with a target key target point / channel based on a prediction of a traditional Chinese and Western medicine collaborative intervention effect, and output the recommended traditional Chinese and Western medicine comprehensive intervention scheme. The present disclosure realizes the feature mapping and fusion of a Western medicine micro model and a traditional Chinese medicine macro model, so that a precise traditional Chinese and Western medicine comprehensive intervention scheme recommendation can be obtained, and the problems in the related art are effectively solved.

Description

Technical Field

[0001] This disclosure relates to the field of computer technology, and in particular to a decision-making system for integrated traditional Chinese and Western medicine intervention. Background Technology

[0002] With the development of medicine, relying solely on either Traditional Chinese Medicine (TCM) or Western medicine is no longer sufficient to meet the clinical needs of patients with complex diseases. Therefore, integrated TCM and Western medicine treatment (TCM-Western medicine combination) has gradually become an important strategy for many chronic and intractable diseases. TCM emphasizes a holistic approach and syndrome differentiation, focusing on regulating the body's Yin-Yang balance, improving symptoms, and enhancing quality of life. Western medicine, on the other hand, is based on clear pathophysiological mechanisms, directly intervening in the disease process through drugs or other means to quickly control the condition. Theoretically, combining the two can leverage their complementary advantages to achieve both symptomatic and root-cause treatment.

[0003] However, in actual clinical application, the effects of combined TCM and Western medicine treatment are not stable, and some diseases have not even shown the expected improvement in overall efficacy. On the one hand, the mechanisms of TCM and Western medicine lack systematic integration: TCM prescriptions are mostly multi-component, multi-target compound formulas, and their effective components and action networks are not yet fully understood; Western medicine treatment targets are clear, but the synergistic or antagonistic relationship between the two systems lacks systematic research, and combined treatment plans often rely on the physician's personal experience, lacking optimized design based on molecular mechanisms. On the other hand, different patients have significant differences in etiology, disease course, constitution, metabolic characteristics, and drug response, making it difficult to achieve precision with fixed TCM and Western medicine combined treatment plans.

[0004] Therefore, there is an urgent need for a systematic approach that integrates traditional Chinese medicine and Western medicine interventions / treatments to improve the stability and effectiveness of collaborative treatment between traditional Chinese medicine and Western medicine. Summary of the Invention

[0005] In view of the shortcomings of the prior art described above, the purpose of this disclosure is to provide a decision-making system for integrated traditional Chinese and Western medicine intervention to solve the problems in the related technologies.

[0006] This disclosure provides a comprehensive TCM-Western medicine intervention decision-making system, comprising: a data acquisition module for collecting physiological state data to be analyzed from a target user, the physiological state data to be analyzed including TCM physiological state data and Western medicine physiological state data; a diagnostic reasoning module for obtaining TCM syndrome information and Western medicine disease information to be analyzed based on the TCM physiological state data and Western medicine disease information, respectively, and obtaining comprehensive TCM-Western medicine diagnostic information for the target user by combining the TCM syndrome information and Western medicine disease information; and a multi-omics mapping module for forming a preset syndrome-pathology mapping relationship between preset pathological information representing preset TCM syndrome information and preset Western medicine disease information; wherein the preset syndrome-pathology mapping relationship is established based on the correlation between preset TCM syndrome information and preset pathological information in signs and / or symptoms; the preset TCM syndrome information is associated with each preset TCM intervention plan with intervention effect, and the preset pathological information corresponds to a target point. The pathway is associated with various preset Western medicine intervention schemes that have an intervention effect; the syndrome pathology mapping information is used to map the pathological mechanism information of the TCM syndrome information to be analyzed to the associated target / pathway fusion network module, which is used to construct / call the fusion biological network corresponding to each preset TCM and Western medicine integrated diagnostic information; wherein, the fusion biological network is obtained by the known biological network corresponding to the preset TCM and Western medicine integrated diagnostic information, and the association relationship between the target / pathway in the known biological network and the corresponding preset intervention scheme; the intervention decision module is used to respond to the target key target / channel matched in the fusion biological network according to the TCM and Western medicine integrated diagnostic information to be analyzed, and based on the prediction of the TCM and Western medicine synergistic intervention effect, to determine the recommended TCM and Western medicine integrated intervention scheme in the preset TCM intervention scheme group and the preset Western medicine intervention scheme group associated with the target key target / channel; the output module is used to output the recommended TCM and Western medicine integrated intervention scheme for determining the target TCM and Western medicine integrated intervention scheme for implementation by the target user.

[0007] In an embodiment of the first aspect, a quantization module is included, which quantizes the physiological state data to be analyzed and converts it into a standardized feature vector, and outputs it to the diagnostic inference module.

[0008] In the first aspect of the embodiment, the Western medical physiological state data to be analyzed includes at least one of the following: vital sign data of the target user collected by the physiological state sensor; Western medical examination / test index data; Western medical diagnostic result data; the Traditional Chinese Medicine physiological state data to be analyzed includes at least one of the following: data collected from the four diagnostic methods of Traditional Chinese Medicine; Traditional Chinese Medicine syndrome data.

[0009] In an embodiment of the first aspect, the data acquisition module is further configured to acquire physiological state data updated after the target integrated traditional Chinese and Western medicine intervention plan is implemented on the target user, so as to obtain an updated recommended integrated traditional Chinese and Western medicine intervention plan through the integrated traditional Chinese and Western medicine intervention decision system.

[0010] In an embodiment of the first aspect, constructing a fusion biological network includes: identifying a known biological network; establishing a correlation between a preset set of Western medicine intervention programs and a first set of targets / pathways with known effects in the known biological network; establishing a correlation between a preset set of traditional Chinese medicine intervention programs and a second set of targets / pathways with known effects in the known biological network; and integrating each of the correlations into the known biological network to obtain a fusion biological network.

[0011] In an embodiment of the first aspect, the intervention decision module includes: an intervention scheme determination module, configured to determine a set of preset traditional Chinese medicine intervention schemes and a set of preset Western medicine intervention schemes associated with the target key target / channel based on the fused biological network; a simulation implementation module, configured to obtain a set of preset traditional Chinese and Western medicine intervention scheme combinations selected from the set of preset traditional Chinese medicine intervention schemes and the set of preset Western medicine intervention schemes, and simulate the implementation of the set of preset traditional Chinese and Western medicine intervention scheme combinations on the target user; and an effect evaluation module, configured to evaluate the intervention effect based on the simulated intervention results, and determine a target set of preset traditional Chinese and Western medicine intervention scheme combinations based on the condition of better synergistic intervention effect, so as to obtain the recommended integrated traditional Chinese and Western medicine intervention scheme based on the target set of preset traditional Chinese and Western medicine intervention scheme combinations.

[0012] In the first aspect of the embodiment, the preset TCM intervention program group is obtained based on screening various preset TCM intervention programs that have synergistic effects with the preset Western medicine intervention program group on the target key target / pathway.

[0013] In an embodiment of the first aspect, determining the target preset combination of traditional Chinese and Western medicine intervention programs based on the condition of better synergistic intervention effect includes: 1) longitudinally comparing the intervention effect of the preset combination of traditional Chinese and Western medicine intervention programs with at least one historical combination of traditional Chinese and Western medicine intervention programs implemented by the target user; 2) horizontally comparing the preset combination of traditional Chinese and Western medicine intervention programs with at least one historical combination of traditional Chinese and Western medicine intervention programs implemented by other individual users / groups; wherein the other individual users / groups have the same syndrome combination type information as the target user.

[0014] In the embodiments of the first aspect, the preset TCM intervention group and / or preset Western medicine intervention group also include non-drug programs.

[0015] In the first aspect of the embodiment, the simulation implementation module is implemented based on a machine learning model; the integrated traditional Chinese and Western medicine intervention decision system further includes: a post-training module, used to obtain the actual intervention results of the target user implementing the target integrated traditional Chinese and Western medicine intervention plan, so as to form training data to train the simulation implementation module.

[0016] As described above, this disclosure relates to the field of computer technology and provides a comprehensive TCM-Western medicine intervention decision-making system, comprising: a data acquisition module for collecting physiological state data of a target user to be analyzed; a diagnostic reasoning module for obtaining TCM syndrome information and Western medicine disease information to be analyzed based on the TCM physiological state data and the Western medicine physiological state data to be analyzed, and obtaining comprehensive TCM-Western medicine diagnostic information; a multi-omics mapping module for mapping pathological mechanism information based on the TCM syndrome information to be analyzed; a fusion network module for constructing / calling a fusion biological network corresponding to each preset comprehensive TCM-Western medicine diagnostic information; an intervention decision-making module for determining a recommended comprehensive TCM-Western medicine intervention plan from a preset TCM intervention plan group and a preset Western medicine intervention plan group associated with the target key target / channel based on the prediction of the synergistic intervention effect of TCM and Western medicine; and an output module for outputting the recommended comprehensive TCM-Western medicine intervention plan. The system integrates the Western medicine micro-model and the TCM macro-model according to feature mapping, thereby obtaining a precise recommendation of a comprehensive TCM-Western medicine intervention plan, effectively solving problems in related technologies. Attached Figure Description

[0017] Figure 1 A schematic diagram of the modules of the integrated traditional Chinese and Western medicine intervention decision-making system in one embodiment of this disclosure is shown.

[0018] Figure 2 A schematic diagram of the intervention decision-making module described in one embodiment of this disclosure is shown.

[0019] Figure 3 A schematic diagram illustrating an application scenario of the integrated traditional Chinese and Western medicine intervention decision-making system in one embodiment of this disclosure.

[0020] Figure 4 This illustration shows a data flow diagram in an application scenario of the integrated traditional Chinese and Western medicine intervention decision-making system in one embodiment of this disclosure.

[0021] Figure 5 A schematic diagram of the structure of a computer device according to an embodiment of the present disclosure is shown. Detailed Implementation

[0022] The following specific examples illustrate the implementation of this disclosure. Those skilled in the art can easily understand other advantages and effects of this disclosure from the information disclosed herein. This disclosure can also be implemented or applied through other different specific embodiments, and various details in this disclosure can be modified or changed according to different viewpoints and application modules without departing from the spirit of this disclosure. It should be noted that, unless otherwise specified, the embodiments and features in the embodiments of this disclosure can be combined with each other.

[0023] The embodiments of this disclosure will now be described in detail with reference to the accompanying drawings, so that those skilled in the art to which this disclosure pertains can readily implement it. This disclosure may be embodied in many different forms and is not limited to the embodiments described herein.

[0024] In this disclosure, references to terms such as "one embodiment," "some embodiments," "example," "specific example," or "some examples," etc., indicate that a specific feature, structure, material, or characteristic represented in connection with that embodiment or example is included in at least one embodiment or example of this disclosure. Furthermore, the specific features, structures, materials, or characteristics represented may be combined in any suitable manner in any one or a group of embodiments or examples. Moreover, without contradiction, those skilled in the art can combine and integrate the different embodiments or examples represented in this disclosure, as well as the features of those different embodiments or examples.

[0025] Furthermore, the terms "first" and "second" are used for illustrative purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one of that feature. In the representation of this disclosure, "a set" means two or more, unless otherwise explicitly specified.

[0026] For the purpose of clarity, devices unrelated to the description are omitted, and the same or similar components throughout the specification are given the same reference numerals.

[0027] Throughout this specification, when it is said that a device is "connected" to another device, this includes not only "direct connection" but also "indirect connection" by placing other components in between. Furthermore, when it is said that a device "comprises" a certain constituent element, unless otherwise stated otherwise, this does not exclude other constituent elements, but rather implies that other constituent elements may be included.

[0028] While the terms first, second, etc., are used in some examples herein to refer to various elements, these elements should not be limited by these terms. These terms are used only to distinguish one element from another. For example, first interface and second interface, etc., are used. Furthermore, as used herein, the singular forms “a,” “an,” and “the” are intended to also include the plural forms unless the context indicates otherwise. It should be further understood that the terms “comprising,” “including,” indicate the presence of the stated feature, step, operation, element, module, item, kind, and / or group, but do not exclude the presence, occurrence, or addition of one or more other features, steps, operations, elements, modules, items, kinds, and / or groups. The terms “or” and “and / or” as used herein are interpreted as inclusive, or mean any one or any combination thereof. Thus, “A, B, or C” or “A, B, and / or C” means “any one of: A; B; C; A and B; A and C; B and C; A, B, and C.” Exceptions to this definition will only occur if the combination of elements, functions, steps, or operations is inherently mutually exclusive in some way.

[0029] The technical terms used herein are for reference only to specific embodiments and are not intended to limit the scope of this disclosure. The singular form used herein includes the plural form unless the statement explicitly indicates otherwise. The word "comprising" as used in this specification means to specify a particular characteristic, region, integer, step, operation, element, and / or component, and does not exclude the presence or addition of other characteristics, regions, integers, steps, operations, elements, and / or components.

[0030] Although not explicitly defined, all terms, including technical and scientific terms used herein, shall have the same meaning as commonly understood by one of ordinary skill in the art to which this disclosure pertains. Terms defined in commonly used dictionaries shall be further interpreted as having a meaning consistent with the information in relevant technical literature and the prompts to be analyzed, and shall not be over-interpreted as having an ideal or overly formulaic meaning unless otherwise defined.

[0031] With the development of medicine, relying solely on traditional Chinese medicine (TCM) or Western medicine treatments is no longer sufficient to meet the clinical needs of patients with complex diseases. Therefore, integrated TCM and Western medicine treatment (TCM-Western medicine combination therapy) has gradually become an important strategy for many chronic and intractable diseases. However, in actual clinical application, the effects of integrated TCM and Western medicine treatment are not stable, and some diseases have not even shown the expected improvement in overall efficacy. On the one hand, the mechanisms of TCM and Western medicine lack systematic integration: TCM prescriptions are mostly multi-component, multi-target compound formulas, and their effective components and action networks are not yet fully understood; Western medicine treatment targets are clear, but the synergistic or antagonistic relationship between the two systems lacks systematic research, and combined treatment plans often rely on the physician's personal experience, lacking optimized design based on molecular mechanisms. On the other hand, different patients have significant differences in etiology, disease course, constitution, metabolic characteristics, and drug responses, making it difficult to achieve precision with fixed integrated TCM and Western medicine plans. Therefore, there is an urgent need for a plan that can systematically integrate TCM and Western medicine interventions / treatments to improve the stability and effectiveness of integrated TCM and Western medicine treatment.

[0032] In view of this, this disclosure provides a decision-making system for integrated traditional Chinese and Western medicine intervention. By constructing a mapping relationship between traditional Chinese medicine "syndromes" and Western medicine "pathology", and using the mapping relationship as a channel, it is possible to select personalized and precise integrated traditional Chinese and Western medicine intervention plans that can synergistically act on overlapping target points / pathways, thereby effectively improving the accuracy, stability and intervention effect of integrated traditional Chinese and Western medicine treatment.

[0033] It should be noted that the user's physiological state data and the behavior of obtaining diagnostic results based on the physiological state data involved in the embodiments of this application are all legally obtained by entities authorized by the user, such as the medical institutions or health devices where the user seeks medical treatment.

[0034] like Figure 1 The diagram shows a module schematic of an integrated traditional Chinese and Western medicine intervention decision-making system in one embodiment of this disclosure.

[0035] exist Figure 1 The integrated Chinese and Western medicine intervention decision system includes: a data acquisition module 110, a diagnostic reasoning module 120, a multi-omics mapping module 130, an intervention decision module 140, and an output module 150.

[0036] The data acquisition module 110 is used to collect physiological state data of the target user to be analyzed, including traditional Chinese medicine physiological state data and Western medicine physiological state data to be analyzed.

[0037] In some embodiments, the Western medicine physiological state data to be analyzed includes at least one of the following: vital sign data of the target user collected by physiological state sensors; Western medicine examination / testing index data; and Western medicine diagnostic result data.

[0038] As an example, the physiological state sensor can be implemented as including vital sign sensors, including at least one of heart rate / pulse sensors, blood oxygen sensors, blood pressure sensors, respiration sensors, body temperature sensors, and electrocardiogram sensors. In some embodiments, the physiological state sensor can be implemented as including vital sign sensors, including at least one of accelerometers, gyroscopes, magnetometers, pressure sensors (placed on the sole of the foot to detect body posture), and electromyography (EMG) sensors. In some embodiments, the physiological state sensor can be implemented as including biochemical sign sensors, which can be invasive / minimally invasive and used to detect biochemical indicators in the body, including at least one of blood glucose sensors, sweat sensors, blood biochemistry sensors, hormone sensors, and breath sensors. In some embodiments, the physiological state sensor can be implemented as including auxiliary monitoring sensors, such as skin conductance sensors, sleep sensors, ultraviolet sensors, and humidity sensors. For example, the physiological state sensor can be mounted on different devices depending on its sensor type. For instance, sensors for measuring heart rate / pulse, blood oxygen, blood pressure, sleep, etc., can be mounted on wearable devices (such as smartwatches, wristbands, etc.); or they can be mounted on medical devices, such as blood pressure monitors, blood glucose meters, etc.

[0039] As an example, the Western medicine examination / testing data may include the results of blood tests, urine tests, biochemical tests, immune tests, and imaging / functional examinations for the target user. For example, results from at least one of the following tests or examinations: complete blood count, comprehensive biochemistry, kidney function, blood glucose / glycated glucose, blood lipids, routine urine test, immune / tumor markers, and imaging. For example, hypertension-related indicators such as ambulatory blood pressure monitoring, blood biochemistry (e.g., renin, angiotensin), and echocardiography.

[0040] As an example, the Western medicine diagnostic results data may be diagnostic data based on Western medicine diseases, and may include qualitative results of whether examination / test indicators are abnormal, such as hypertension, hyperglycemia, high cholesterol, hyperlipidemia, etc.

[0041] In some embodiments, the TCM physiological state data to be analyzed includes at least one of the following: data collected from the four diagnostic methods of TCM; and TCM syndrome data.

[0042] The data collected in the TCM four diagnostic methods include objective data collected from the four diagnostic methods of "inspection, auscultation and olfaction, inquiry, and palpation." Among them, the data obtained from "inspection" are the most direct objective signs and have the highest weight in diagnosis. Specifically, inspection first examines the whole body and then the local areas, with the core being spirit, complexion, shape, posture, and tongue appearance. Among these, tongue appearance is the core data of inspection and also the most easily objective indicator in the research of integrated TCM and Western medicine. Observation includes observing the spirit (consciousness, spirit, and eyes, obtaining observation data such as spirited / lack spirit / little spirit / dull spirit, bright / dull / listless eyes, etc.), observing the complexion (such as face color, lip color, nail color, etc., obtaining observation data such as pale / sallow / yellow / flushed / bluish / dull complexion; pale / deep red / bluish lips), observing the shape (such as body type and constitution, obtaining observation data such as fat / thin / medium build, strong / weak, obese with large abdomen / emaciated, etc.), observing the posture (such as body position, movements, and posture, obtaining observation data such as voluntary activity / limb contracture / hemiplegia; preferring to lie down / preferring to sit / restlessness), and observing the tongue (tongue color, tongue shape, tongue coating, and tongue posture, obtaining observation data such as pale red tongue color, large tongue shape, white / yellow / black tongue coating, soft / hard / crooked tongue posture, etc.). Auscultation includes listening to sounds and odors, obtaining data such as: a loud / weak voice, steady / short breathing, dry / clear / heavy cough, etc.; and odors such as: odorless / foul / sour breath, odorless / fishy sputum and nasal discharge, odorless / sour / fishy odor of urine and feces, etc. Inquiry involves asking the patient about chills / fever, sweating, head and body, bowel movements, urination, diet, chest and ribs, ears and eyes, sleep, emotions, menstruation / leukorrhea, etc., obtaining data such as: chills / shivering / heat intolerance / low-grade fever, spontaneous sweating / night sweats, headache / body aches / limb numbness, bowel and bladder function, appetite / taste / drinking water, sleep, and mood. Palpation, or pulse diagnosis, involves obtaining four elements: pulse location, pulse rate, pulse shape, and pulse strength to obtain pulse characteristics. Palpation data includes pulse location (floating / deep / hidden), pulse rate (slow / rapid / moderate / intermittent), pulse shape (bound / fine / slippery / hesitant / wiry / tight / soft), pulse strength (weak / full / bound / weak), and pulse rhythm (regular / irregular / intermittent).

[0043] The TCM syndrome data mentioned above are obtained through dialectical analysis and synthesis based on TCM syndrome data. The dialectical methods include syndrome differentiation based on the Eight Principles, Zang-Fu organs, Qi, Blood, and Body Fluids, exogenous diseases, and etiology and pathogenesis. Examples of syndromes include Qi deficiency, excessive heart fire, wind-cold invading the lungs, and wind-heat invading the lungs.

[0044] In some embodiments, the physiological state data to be analyzed may also include the target user's historical data, such as medical history and health history data from traditional Chinese medicine and Western medicine.

[0045] In some embodiments, the data acquisition module 110 may also be implemented as at least one of a communication interface, an input interface, an audio / video acquisition device, etc., to acquire (e.g., capture, record, receive / input) the Western medicine examination / test indicator data and Western medicine diagnostic result data in text / audio / video form.

[0046] In some embodiments, the integrated traditional Chinese and Western medicine intervention decision-making system may further include a quantification module for quantifying the physiological state data to be analyzed and converting it into a standardized feature vector, which is then output to the diagnostic reasoning module 120. In some embodiments, different elements in the standardized feature vector correspond to various types of items in the pre-determined physiological state data. For example, various Western medicine examination / testing indicator data listed above, and various traditional Chinese medicine diagnostic data collected through the four diagnostic methods.

[0047] As an example, for the physiological state data to be analyzed, the quantified elements represent the degree of good / badness of the physiological state indicated by a certain data point in traditional Chinese medicine or Western medicine. For example, the raw blood glucose and blood pressure values ​​in the Western medicine physiological state data are represented by feature values ​​at corresponding positions in the constructed standardized feature vector. The Western medicine diagnostic results data in the Western medicine physiological state data can be used to determine the severity level through semantic parsing and with the help of Western medicine clinical guidelines, such as grade 0 hypertension (i.e., no hypertension), grade 1 hypertension, grade 2 hypertension, and grade 3 hypertension, which correspond to indicator values ​​of 0, 1, 2, and 3, respectively. Alternatively, the raw values ​​can be used, such as a blood pressure value of 120 / 95. These values ​​can all be represented as feature values ​​in the standardized feature vector after being transformed from the raw values.

[0048] For example, data on physiological states in Traditional Chinese Medicine (TCM) can also be quantified. As an example, quantification can be achieved based on known physical quantities or levels corresponding to the severity. For instance, "red tongue" can be quantified by taking an image of the tongue and obtaining its value in a color space (such as the HSV three-channel). Furthermore, each syndrome can be quantified using a syndrome scoring scale. This scale assigns scores based on indicators such as primary symptoms, secondary symptoms, and tongue and pulse characteristics (e.g., 0 points = no symptoms, 3 points = severe symptoms) to form a total score, reflecting the severity of the syndrome and thus achieving quantification.

[0049] In some embodiments, the vectorization of the standardized feature vector can be achieved by directly arranging the original data of the TCM physiological state data in sequence to form a vector, or by performing vectorization processing (such as normalization or standardization), or by encoding it through a specific encoding method, such as heat extraction or deep learning methods (BERT, embedding, etc.). For example, after quantifying the data of several predetermined standard dimensions in the physiological state data to be analyzed, all indicators (whether Western medicine quantitative or TCM qualitative) are converted into unitless standardized values ​​(such as 0~1), resulting in age (0.5), systolic blood pressure (0.7), blood sugar (0.3), gender (1), blood type (0,1,0,0), disease severity (1), pneumonia (0.8), and tumor size (0.6). After concatenation, the standardized feature vector [0.5, 0.7, 0.3, 1, 0, 1, 0, 0, 1, 0.8, 0.6] is obtained.

[0050] The diagnostic reasoning module 120 is used to obtain the TCM syndrome information and the Western medicine disease information to be analyzed based on the TCM physiological state data and the Western medicine physiological state data to be analyzed, respectively, and to obtain the comprehensive TCM and Western medicine diagnostic information of the target user by combining the TCM syndrome information and the Western medicine disease information. Specifically, based on the standardized feature vector of the quantified physiological state data to be analyzed, the diagnostic reasoning module 120 can calculate and infer the corresponding TCM syndrome information and the Western medicine disease information to be analyzed.

[0051] The integrated diagnostic information from both traditional Chinese medicine and Western medicine to be analyzed is a comprehensive result of the analysis of TCM syndrome information and Western medicine disease information. For example, if the TCM syndrome information to be analyzed is liver yang hyperactivity and the Western medicine disease information to be analyzed is hypertension, then the integrated diagnostic information from both TCM and Western medicine to be analyzed is liver yang hyperactivity type hypertension. Taking hypertension as an example, in traditional Chinese medicine, it can also include types such as phlegm-dampness obstruction, yin deficiency with yang hyperactivity, qi and blood deficiency, and kidney essence deficiency.

[0052] In some embodiments, the reasoning rules of the diagnostic reasoning module 120 can be derived from knowledge graphs obtained by structuring data based on relevant Chinese and Western medicine diagnostic logic. For example, computational rules extracted / summarized / learned from Chinese medicine dialectical knowledge graphs and Western medicine diagnostic knowledge graphs can be used for inferring syndromes / diseases. The reasoning rules quantify and transform the semantic relationships between Chinese and Western medicine pathological state data and Chinese medicine syndrome and Western medicine disease information into computational logic, satisfying the reasoning requirements of syndrome integration and pathological integration, while ensuring the interpretability and clinical consistency of the rules.

[0053] In some embodiments, TCM syndrome information can be quantitatively characterized based on methods such as syndrome scores / syndrome indices.

[0054] For example, based on the principles of Traditional Chinese Medicine (TCM) syndrome differentiation, symptom characteristic values, clinical weights, and syndrome calculation rules can be constructed. These contents are presented in the form of a TCM syndrome differentiation rule table, which includes syndrome type identifiers, symptom names, symptom characteristic values ​​(X), clinical weights (W), primary and secondary correction coefficients (K), and syndrome integral calculation formulas. A syndrome type identifier might be, for example, Liver Yang Rising. Symptoms might include flushed face and red eyes, dizziness and headache, irritability, and a red tongue with little saliva. Symptom characteristic values ​​can be represented as values ​​between [0,1], corresponding to the severity of the symptoms. Clinical weights quantify the importance of clinical elements such as symptoms / signs in diagnostic judgment. The primary and secondary correction coefficients are used to assign importance to primary symptoms, secondary symptoms, and concurrent symptoms; primary symptoms have higher weights, secondary symptoms have lower weights, and concurrent symptoms have even lower weights. The result of each syndrome integral is calculated as X*W*K*a preset multiple, where the preset multiple is selected according to expression habits. By summing the scores of various symptoms (e.g., X*W*multiple), quantitative information on TCM syndromes is obtained, such as syndrome type: Liver Yang Rising, score (i.e. confidence level): 0.85, etc.

[0055] In some embodiments, Western medicine disease information can be quantitatively represented based on methods such as disease scores / indices. "Disease" can include a disease or a sub-healthy state / functional impairment that does not reach the level of a disease. The quantitative representation of Western medicine disease information can be achieved using scale scores or indices based on quantitative indicators of Western medicine psychological state data, similar to the principles described above. For example, the score calculation for acute ischemic stroke uses age (e.g., scores from low to high for those under 60 and over 60), blood pressure (scores from low to high for those below and above standard blood pressure), clinical characteristics (scores from low to high based on the number and / or importance of characteristic manifestations of stroke), symptom duration (scores are positively correlated with duration), and diabetes (scores from low to high based on presence / absence), etc., as indicators. The scores of these indicators are summed to obtain the score for acute ischemic stroke. Examples of indices include Body Mass Index (BMI), Skeletal Muscle Index (SMU), and Basal Metabolic Rate (BMR); another example is the "Systemic Lupus Erythematosus Activity Index-2000 (SLEDAI-2K)" for lupus, which covers the following: Nervous system: epilepsy, psychiatric symptoms, cerebrovascular disease, etc.; Kidney damage: proteinuria, hematuria, cylindruria; Skin and mucous membranes: rash, oral ulcers, hair loss; Other systems: arthritis, serositis, fever, etc.; Laboratory indicators: decreased complement, positive anti-dsDNA antibody, thrombocytopenia, etc. These are just examples and not exhaustive.

[0056] For example, based on the principles of Western medical pathology diagnosis, target feature values, pathological weights, and pathological calculation rules can be constructed. These contents are presented in the form of a Western medical pathology diagnosis rule table, which includes disease identifiers, target / pathway names, target / pathway feature values ​​(X), pathological weights (W), activation thresholds (T), and integral calculation formulas (such as X*W*multiples). As an example, a disease identifier might be hypertension, target / pathway names might include Ang II, AT1R receptor, RAAS pathway, ACE, etc., and target / pathway feature values ​​might be [0, 1]. The activation threshold indicates whether the target / pathway is allowed to participate in the calculation under the current disease identifier (a binary term, 0 or 1). By summing the integrals of each target / pathway (such as X*W*multiples), quantified Western medical disease information is obtained.

[0057] Of course, if the physiological state data to be analyzed directly contains information about syndromes and diseases (such as prior diagnoses from physicians), it can be directly used in the diagnostic reasoning module 120. Specifically, the knowledge graph transforms the entity attributes (such as the incidence rate of diseases, the duration of symptoms, and the properties of Chinese medicine) and relationships between entities (such as "coughing is a symptom of pneumonia" and "spleen deficiency leads to loss of appetite") of diagnostic and treatment entities (such as indicators, syndromes, and diseases) in both traditional Chinese and Western medicine into a graph network, i.e., a knowledge graph, according to a unified knowledge representation framework (such as RDF / OWL, Label-Property Graph, a commonly used industrial graph database). This allows the graph network to enable machines to understand the relationships between nodes. Among them, the indicators, syndromes, and diseases of various physiological state data can be used as nodes in the graph, and the associations between them are "edges," which can have edge weights to represent the degree of association. Thus, based on the physiological state data to be analyzed, the TCM syndrome information and Western medicine disease information with the highest probability are determined through knowledge graph navigation. In the Western medicine diagnostic knowledge graph, the edges and their weights between nodes can be set based on Western medicine diagnostic rules (such as evidence-based medicine guidelines, clinical pathways, authoritative consensus, etc.). Similarly, the edges and their weights between nodes in the Traditional Chinese Medicine (TCM) syndrome differentiation knowledge graph can be set based on syndrome differentiation rules. For example, a patient with severe chills, mild fever, no sweating, nasal congestion with clear runny nose, cough with white phlegm, pale red tongue with thin white coating, and a floating and tight pulse can be identified as having a high probability of contracting the common cold – wind-cold exterior syndrome – through the nodes in the graph.

[0058] The multi-omics mapping module 130 is used to form a preset syndrome-pathology mapping relationship between preset pathological information representing preset TCM syndrome information and preset Western medicine disease information. Multi-omics, also known as ensemble omics, pan-omics, and cross-omics, is a research method that comprehensively utilizes two or more omics technologies. Its core lies in "integration" and "systematicity," aiming to comprehensively reveal the biological characteristics of organisms and their dynamic changes under different conditions by integrating data from different omics levels (such as genomics, transcriptomics, proteomics, metabolomics, etc.), thereby systematically analyzing the interactions and functional mechanisms at different molecular levels in biological systems. Multi-omics reveals the full picture of complex biological problems by jointly analyzing data from different molecular levels. Multi-omics encompasses various omics technologies, including but not limited to: Genomics: focusing on the structure, function, variation, and evolutionary laws of the genome, using techniques such as whole-genome sequencing to study gene mutations, individual genetic diversity, and other issues. Transcriptomics: analyzing the types, quantities, and expression levels of RNA in cells to reveal dynamic changes in gene expression; its techniques include RNA-seq, etc. Proteomics: Studies the types, structures, modifications, and functions of proteins in cells, tissues, or organisms, using techniques such as mass spectrometry. Metabolomics: Reflects the real-time physiological state of an organism, reveals the relationship between metabolic disorders and diseases, and discovers biomarkers.

[0059] The preset syndrome-pathology mapping relationship is established based on the correlation between preset TCM syndrome information and preset pathological information in terms of signs and / or symptoms. Taking liver yang hyperactivity-hypertension as an example, common symptoms / signs include facial flushing, headache, dizziness, irritability, strong and forceful pulse, and red tongue with little saliva. Among these, facial flushing, headache, and dizziness in liver yang hyperactivity may correspond to the Western medical pathology of hypertension, such as persistently elevated blood pressure (especially increased systolic blood pressure / pulse pressure) and increased cerebrovascular resistance. Existing technologies provide relevant experimental evidence, showing that the SBP / DBP in the liver yang hyperactivity group are higher than those in the age-matched healthy group and are positively correlated with symptom scores, which can serve as supporting evidence. Irritability and a strong and forceful pulse correspond to the Western medical pathology of increased sympathetic nerve excitability, faster heart rate, and elevated blood catecholamine levels. Existing technologies provide relevant evidence for this, showing that patients with liver yang hyperactivity-type hypertension have significantly higher plasma norepinephrine (NE) and epinephrine (E) levels than those without this syndrome type, which can also serve as supporting evidence. A red tongue with little saliva corresponds to elevated levels of oxidative stress, increased free radical production, and decreased antioxidant capacity in the body. There is supporting evidence for this in existing research; patients with this syndrome type show significantly elevated serum malondialdehyde (MDA) and decreased superoxide dismutase (SOD). Therefore, it is evident that a possible mapping relationship exists between TCM syndromes and Western medical pathology. However, this mapping relationship may manifest as a complex interplay between the multidimensional combination of symptoms / signs in TCM syndromes and the multidimensional indicators of Western medical pathology, rather than a simple one-to-one relationship.

[0060] Therefore, despite the complexity, the analysis focuses on the relationship between the pre-defined TCM syndrome information and the pre-defined pathological information to establish the pre-defined syndrome-pathological mapping relationship. In some optional embodiments, firstly, methods such as correlation analysis based on the aforementioned relationship can be used to screen out characteristic pathologies highly correlated with the syndrome, thereby eliminating pathological noise unrelated to the syndrome. Further, quantified syndrome information (such as syndrome score / index) can be used as the dependent variable / label, and the screened characteristic pathologies as independent variables. By constructing a mapping relationship model, the quantitative correlation patterns between the two can be explored, and the reliability of these patterns can be verified through external sample sets, clinical validation, and other methods, ultimately forming a stable pre-defined syndrome-pathological mapping relationship.

[0061] For example, by pre-setting a syndrome-pathology mapping relationship, it can be used to clarify which core pathological molecular features of a certain syndrome are significantly correlated with a certain Western medicine disease. For instance, "Liver Yang Rising Syndrome (hypertension) is significantly correlated with elevated serum oxidative stress metabolites (such as MDA and ROS), upregulated angiotensin II (Ang II) expression, and differential miR-155 expression," thus finding a specific microscopic material basis for macroscopic syndrome mapping. More specifically, the pre-set syndrome-pathology mapping relationship can be expressed quantitatively. For example, by fitting, regression, or machine learning models, a quantitative calculation formula / association threshold between syndrome quantitative indicators (integral / index) and pathological information can be approximated, such as the calculation relationship between the increase in the Liver Yang Rising Syndrome score and the increase in serum Ang II concentration and the average increase in MDA concentration.

[0062] The following is a simple example of obtaining the mapping relationship between "hypertension and liver yang hyperactivity syndrome". The multi-omics mapping module 130 inputs preset liver yang hyperactivity syndrome information (which may come from a unified syndrome scoring table or the score of liver yang hyperactivity syndrome in the diagnostic criteria) and preset pathological information of hypertension (which may come from the diagnostic criteria of grade x hypertension in Western medicine) (such as serum metabolomics and peripheral blood transcriptomics detection data). The multi-omics mapping module 130 performs standardized preprocessing on syndrome scores, blood pressure values, and multi-omics data, and screens out differentially expressed metabolites (such as Ang II, MDA) and differentially expressed genes (such as ACE, Nox4) between patients with hypertension and liver yang hyperactivity syndrome, non-liver yang hyperactivity syndrome patients, and healthy individuals.

[0063] Using the liver-yang hyperactivity syndrome score as a label, a mapping model was used to explore the quantitative correlation between the score and the expression levels of differentially expressed metabolites / genes, thereby outputting a pre-defined syndrome-pathology mapping relationship. For example, the liver-yang hyperactivity syndrome score was positively correlated with Ang II expression (r=0.78, P<0.001) and positively correlated with MDA expression (r=0.72, P<0.001). When Ang II ≥ X ng / L and MDA ≥ Y μmol / L, the sensitivity and specificity for diagnosing liver-yang hyperactivity syndrome were 85% and 82%, respectively.

[0064] In some embodiments, the mapping relationship model can be implemented as a statistical model (such as a regression model, clustering model) or a machine learning model (such as a random forest, SVM, deep neural network, etc.). Preferably, the mapping relationship model can be implemented as a deep neural network model, such as a fully connected neural network (FCNN / DNN), or a multilayer perceptron and attention mechanism (MLP-Attention) model, an autoencoder (AE) / variable autoencoder (VAE), or a graph neural network (GNN / GCN) combined with a fully connected neural network (FCNN / DNN), etc.

[0065] For example, a fully connected neural network (FCNN / DNN) includes an input layer, hidden layers, and an output layer. A training dataset is constructed, such as serum metabolomic markers (e.g., Ang II, MDA, NO) and peripheral blood transcriptomic genes (ACE, Nox4) labeled as syndrome scores for liver yang hyperactivity syndrome in hypertensive patients. This training dataset is input into the input layer of the fully connected neural network. The model parameters are iteratively optimized based on the loss between the predicted syndrome scores regressed from the output layer and the labeled syndrome scores. Once training is complete, a mapping relationship model is obtained.

[0066] MLP-Attention+DNN is similar to the training method of fully connected neural networks (the training dataset, model initialization, and loss function settings can be the same), except that an attention layer is added to further extract features from the input, assign attention weights to each feature before proceeding to subsequent calculations, and the mapping relationship model can be obtained after training is completed.

[0067] The training method of AE / VAE + DNN (autoencoder combined with fully connected network) first extracts core features from high-dimensional pathological data through autoencoder (unsupervised learning), and then uses DNN to train the association between core features and syndrome integrals.

[0068] The training approach using GNN / GCN (Graph Neural Network) + DNN constructs pathological data into a "graph structure." For example, pathological molecules (metabolites / genes) are first constructed as a "molecular interaction graph" (nodes = molecules, edges = molecular interactions). This molecular interaction graph can be filtered from known biological networks (such as DisGeNET, GeneMANIA, etc.) to obtain the edges between the nodes (metabolites / genes) required in the study. Then, GCN learns the global features of the molecular interaction graph through "graph convolution," and finally outputs the predicted syndrome integral through a fully connected layer. The training process still involves backpropagation to optimize parameters, but the data transfer is based on the results of convolution operations on the graph structure.

[0069] The preset TCM syndrome information is associated with various preset TCM intervention programs that have an interventional effect, and the target / pathway corresponding to the preset pathological information is associated with various preset Western medicine intervention programs that have an interventional effect. The syndrome-pathology mapping information is used to map the TCM syndrome information to be analyzed to the associated target / pathway indicated by the pathological mechanism information. In some embodiments, the preset TCM syndrome information and its associated preset TCM intervention programs, as well as the preset Western medicine intervention programs associated with the target / pathway corresponding to the preset pathological information, can all be obtained through authoritative literature / guidelines, public databases, clinical research data, classical theoretical systems, and other scientific evidence in related technologies.

[0070] Taking hypertension with liver yang hyperactivity as an example, the system pre-sets TCM syndrome information (liver yang hyperactivity syndrome), pre-set TCM intervention plans (such as Tianma Gouteng Decoction, Zhengan Xifeng Decoction, Taichong / Baihui acupuncture, etc., all of which have the effect of calming the liver and suppressing yang), pre-set pathological information (hypertension abnormal metabolism / gene expression), corresponding targets / pathways (such as RAS pathway, oxidative stress pathway, targets ACE, AT1R, Nox4), and corresponding pre-set Western medicine intervention plans (such as ACE inhibitors such as captopril, AT1R antagonists such as losartan, Nox4 inhibitors such as apocynin, etc., all of which have the effect of targeted intervention).

[0071] The fusion network module is used to construct / call a fusion biological network 160 corresponding to each preset integrated traditional Chinese and Western medicine diagnostic information. The fusion biological network 160 is obtained from known biological networks and the association relationships between targets / pathways in the known biological networks and corresponding preset intervention schemes. Exemplarily, this disclosure provides an example of constructing the fusion biological network 160. First, known biological networks are identified, including but not limited to one or more combinations of protein-protein interaction networks (PPINetwork), signaling pathway networks (Signaling Pathway Network), gene co-expression networks (GCN), and metabolic networks (Metabolic Network). Further, the association relationship between the preset Western medicine intervention scheme set and its first set of targets / pathways with known effects in the known biological networks is established. Specifically, the effects of the Chinese and Western medicine intervention programs on the targets / channels in the above-mentioned known biological network are determined based on credible evidence supported by experimental / clinical evidence (such as legally obtained clinical data). The correlation is then quantified according to the degree of effect, thereby obtaining the "edges" and "edge weights" between "nodes" (elements in the target and intervention program, such as components), thus forming the fusion biological network 160.

[0072] The intervention decision module 140 is used to respond to the target key target / channel matched in the fused biological network 160 based on the integrated TCM and Western medicine diagnostic information to be analyzed, and to determine the recommended integrated TCM and Western medicine intervention plan from the preset TCM intervention plan group and the preset Western medicine intervention plan group associated with the target key target / channel based on the prediction of the TCM and Western medicine synergistic intervention effect.

[0073] It is understandable that after constructing the fusion biological network 160, the network can be used to navigate to key targets / pathways of interest through at least one of the following methods: network topology analysis, weighted summation of TCM and Western medicine features, and clinical evidence screening, based on integrated TCM and Western medicine diagnostic information. This allows for the determination of pre-defined TCM and Western medicine intervention plans with high correlation (corresponding edge weights). For example, taking hypertension of the liver-yang hyperactivity type as an example, the fusion biological network 160 can be cross-screened from several dimensions: Western medicine pathology, TCM syndrome type, fusion correlation, and clinical basis, eliminating irrelevant / weakly correlated nodes to obtain key targets / pathways. For instance, according to Western medicine pathology, core hypertension pathways (RAAS, sympathetic nervous system, etc.) can be enriched and a set of candidate targets / pathways can be mapped. According to TCM syndrome type, a set of candidate targets / pathways strongly correlated with the core pathogenesis / syndrome of liver-yang hyperactivity can be screened, extracting a set of candidate targets / pathways with strong cross-domain correlation (fusion edges / nodes) between TCM and Western medicine. This is then validated through patient omics / clinical indicators to ensure that the candidate targets / pathways are genuinely abnormally expressed. The criticality score is calculated for the above candidate targets / pathways, which is the weighted sum of scores in three aspects: Western medicine pathology, TCM syndrome type, and fusion association. The critical targets / pathways are then determined from the candidate targets / pathways according to the criticality score.

[0074] In some embodiments, the preset intervention plan can be a treatment plan, which can be divided into traditional Chinese medicine intervention plans and Western medicine intervention plans, depending on whether drugs are used. It can also be divided into drug intervention plans or non-drug intervention plans. Non-drug intervention plans include, but are not limited to, one or more of acupuncture / moxibustion interventions, massage / tuina, exercise / qigong, and emotional regulation.

[0075] Specifically, corresponding to pre-set integrated TCM and Western medicine diagnostic information, such as "liver yang hyperactivity type hypertension," a fusion biological network 160 is constructed. Based on the original biological network of hypertension containing "gene-protein-pathway-pathology," the associated syndrome types are obtained based on the pre-set syndrome-pathology mapping relationship. Combined with known pathological and syndrome types and pre-set intervention plans, a fusion biological network 160 is determined, defining "gene-protein (i.e., corresponding target)-pathway (target constitutes pathway)-pathology-syndrome type," as well as pre-set intervention plans (such as TCM and Western medicine drugs or non-drug interventions) that can act on the corresponding targets / pathways associated with the pathology and syndrome types. The correlation between different components in TCM and Western medicine potentially acting on different targets / channels can also be reflected in the fusion biological network 160. Therefore, it can be understood that by establishing the fusion biological network 160, when selecting integrated TCM and Western medicine intervention plans, the overlapping synergistic effects of the selected pre-set TCM intervention plan and the pre-set Western medicine / TCM plan on the same targets / channels can be considered. In other words, more broadly speaking, whether a synergistic effect is achieved along the "neuro-endocrine-immune regulation" pathway.

[0076] Taking the fusion biological network 160 corresponding to hypertension of the liver-yang hyperactivity type as an example, the fusion biological network 160 can include, for example, "ACEI / ARB-type Western medicine → target ACE" and "Gastrodia elata and Uncaria rhynchophylla - containing rhynchophylline / Eucommia ulmoides → target ACE", forming a bidirectional association of "Western medicine → ACE ← Chinese medicine components, ACE regulates the RAAS pathway". Therefore, by combining ACEI / ARB-type Western medicine with Gastrodia elata and Uncaria rhynchophylla decoction to act on ACE, a synergistic effect can be achieved in blocking RAAS activation and cross-module transmission to the sympathetic nervous system and inflammation (including the target inflammasome NLRP3).

[0077] Therefore, it can be understood that the intervention decision module 140, by utilizing the fusion biological network 160, can determine a comprehensive intervention plan of traditional Chinese and Western medicine that can accurately block the core pathological links of the disease, thereby achieving a synergistic effect of precise blocking by Western medicine combined with multi-dimensional regulation by traditional Chinese medicine.

[0078] In some embodiments, the target key point / channel can be obtained based on the physiological state data of the target user to be analyzed. For example, for target users with hypertension due to liver yang hyperactivity, the sensitivity of some traditional Chinese medicine and Western medicine indicators to the drugs used can be determined based on their medical history and health history in the physiological state data to be analyzed. This can be determined by physicians or by machine statistical analysis. Taking hypertension due to liver yang hyperactivity as an example, if the analysis highlights the key role of the RAAS system, the RAAS (renin-angiotensin-aldosterone system) is the core pathway for blood pressure regulation and water and electrolyte metabolism, and it is also the core pathological target of hypertension and cardiovascular diseases. Its key intervention targets are all protein / receptor molecules that play a core regulatory role in the pathway. The core regulatory pathway is the classic angiotensin pathway (main pathway), and it also includes the aldosterone pathway (downstream extension pathway). The two work together to constitute the complete functional system of the RAAS. The classic angiotensin pathway includes renin → angiotensinogen (AGT) → angiotensin I (Ang I) → ACE → angiotensin II (Ang II) → AT1R / AT2R. The aldosterone pathway includes Ang II (AT1R activation) → adrenal cortex → MR (mineralocorticoid receptor) → aldosterone (ALD) secretion. The intervention targets for RAAS are selected around the key regulatory nodes of the above two pathways. Among them, ACE, AT1R, renin, and MR are the key target targets (the most mature clinical intervention and the most sufficient evidence), while AT2R and ACE2 are auxiliary regulatory targets (cutting-edge research hotspots, playing an antagonistic / balancing role in RAAS). All targets are protein targets (the core targets of RAAS have no metabolites / nucleic acids).

[0079] In the basic principle of the intervention decision module 140, navigation based on the fused biological network 160 can determine integrated TCM and Western medicine intervention programs that are highly correlated with key target points / channels. Specifically, integrated TCM and Western medicine ACEI / ARB drugs directly block the catalytic core (ACE) and effector core (AT1R) of the RAAS, respectively. Therefore, ACEI / ARB drugs can be preferentially recommended, especially for treating liver yang hyperactivity. Furthermore, in the preset TCM intervention program for liver yang hyperactivity, the gastrodin, rhubarb alkaloid, and baicalin in the Tianma Gouteng Decoction can significantly reduce serum Ang II levels, inhibit ACE activity, and downregulate AT1R expression, thus blocking the RAAS pathway from both upstream (ACE) and downstream (Ang II / AT1R). This forms a target-superimposed inhibition with ACEI / ARB drugs, resulting in a more stable antihypertensive effect. In addition to drug intervention, for patients with hypertension due to liver yang hyperactivity, which is characterized by "liver stagnation transforming into fire and liver yang disturbing the upper body," leading to excitation of the central sympathetic nerve center (nucleus tractus solitarius in the medulla oblongata), non-drug intervention can be implemented by "maintaining regular sleep patterns, avoiding emotional excitement, and using methods to soothe and relax emotions" to reduce / block the triggers for sympathetic excitation. In summary, a theoretical TCM intervention plan and a Western medicine intervention plan can be derived for this type of hypertension, forming a comprehensive TCM-Western medicine intervention plan.

[0080] However, the integrated traditional Chinese and Western medicine intervention plan obtained directly from the fusion biological network 160 is only a theoretically optimal plan. Due to individual differences in physical constitution, the actual implementation may vary for different target users. Therefore, in some embodiments, the intervention decision module 140 can simulate the intervention plan group obtained from the fusion biological network 160 and apply it to the target user to obtain simulated intervention results. Based on these simulated intervention results, the intervention effect can be judged, and thus, a recommended integrated traditional Chinese and Western medicine intervention plan can be formed by selecting the optimal plan from the traditional Chinese medicine intervention plan group and the Western medicine intervention plan group obtained from the fusion biological network 160.

[0081] It should be noted that in other embodiments, if the analysis highlights the key role of the sympathetic nervous system, the corresponding Chinese and Western medicine intervention plans of the intervention decision module 140 will change.

[0082] like Figure 2 The present invention provides a schematic diagram of the intervention decision module 140 in one embodiment of the present disclosure.

[0083] The intervention decision-making module 140 includes an intervention plan determination module 141, a simulation implementation module 142, and an effect evaluation module 143.

[0084] The intervention program determination module 141 is used to determine, based on the fusion biological network 160, a set of preset traditional Chinese medicine (TCM) intervention programs and a set of preset Western medicine intervention programs associated with the target key target / pathway. As previously exemplified, by navigating the fusion biological network 160, preset TCM intervention program groups and preset Western medicine intervention program groups highly associated with the target key target / pathway can be determined. In some embodiments, the preset TCM intervention program groups are obtained by screening various preset TCM intervention programs that have synergistic effects with the preset Western medicine intervention program groups on the target key target / pathway, i.e., those that have overlapping effects on the same target key target / pathway.

[0085] The simulation implementation module 142 is used to acquire a preset combination of traditional Chinese medicine and Western medicine intervention plans selected from the preset traditional Chinese medicine intervention plan group and the preset Western medicine intervention plan group, and to simulate the intervention results of implementing the preset combination of traditional Chinese medicine and Western medicine intervention plans on the target user. In some embodiments, the simulation implementation module 142 may include or invoke an intervention result prediction model. The intervention result prediction model may be implemented as a traditional regression or neural network model.

[0086] For example, the intervention outcome prediction model can be implemented as a traditional regression model, including multiple linear regression (MLR), ridge regression / lasso regression (Lasso / Ridge), random forest regression (RFR), gradient boosting regression (XGBoost / LightGBM / CatBoost), or support vector regression (SVR). The training principle of these models is to learn the explicit association between features and labels from the data, optimize the model parameters by minimizing the prediction error, and finally obtain reusable prediction rules. Training data may include actual pre- and post-intervention physiological state data, as well as traditional Chinese medicine and Western medicine intervention plans.

[0087] As an example, the physiological state data before / after intervention in Western medicine includes, but is not limited to, basic physiological indicators, laboratory test indicators, pathological target indicators, and clinical history indicators. The physiological state data before / after intervention in Traditional Chinese Medicine includes, but is not limited to, syndrome indicators, constitution / tongue and pulse indicators, and TCM medical history indicators. The characteristics of the intervention plan include, for example, the characteristics of the Western medicine plan, the characteristics of the TCM plan, and the characteristics of the combination of Western and TCM.

[0088] Specifically, MLR learns a linear prediction formula, such as post-intervention systolic blood pressure = a × pre-intervention systolic blood pressure + b × protocol intensity + constant term. Using mean squared error (MSE) as the core loss function, the coefficients (a, b, etc.) and constant term in the linear formula are solved using least squares or gradient descent to minimize the loss function, thus obtaining the model. Ridge regression / lasso regression, based on multiple linear regression, addresses feature multicollinearity (such as the high correlation between RAAS targets and sympathetic targets) and overfitting, while preserving the interpretability of linear predictions. Random forest regression uses bootstrap sampling to extract multiple subsets of samples from the training set. During training of each decision tree, only a subset of features (not all features) are randomly selected for splitting, ensuring the diversity between decision trees. Training is completed by building individual decision trees to form a random forest. Training other models can refer to relevant techniques; only some are exemplified here.

[0089] For example, the intervention result prediction model can be implemented as a deep neural network model, including but not limited to multilayer perceptrons (MLP), fully connected neural networks (DNN), convolutional neural networks (CNN), and multilayer perceptrons / convolutional neural networks with attention mechanisms. The training of the deep neural network model also follows the input of training data to obtain the predicted output, calculates the difference loss between the predicted output and the label, adjusts the model parameters based on the loss through backpropagation, and finally completes the training.

[0090] For example, the intervention outcome prediction model can also be implemented as a dedicated optimization model more suitable for the heterogeneous characteristics of traditional Chinese medicine and Western medicine. For instance, a rule-embedded fully connected neural network (Rule-Embedded DNN). That is, clinical rules from both traditional Chinese and Western medicine (such as "Gastrodia and Uncaria Decoction + ARB synergistic regulation of the RAAS pathway") are embedded into the model's loss function. In a specific embodiment, these clinical rules can be transformed into quantifiable constraints and added as an additional loss term (rule loss) to the original mean squared error loss function of an MLP, forming a new total loss function. For example, total loss = mean squared error loss (original loss function) + rule loss weight × rule loss. This avoids the model's prediction results from deviating from clinical logic during training.

[0091] The effect evaluation module 143 is used to evaluate the intervention effect based on the simulated intervention results, and determine the target preset combination of traditional Chinese and Western medicine intervention schemes based on the condition that the synergistic intervention effect is better, so as to obtain the recommended integrated traditional Chinese and Western medicine intervention scheme based on the target preset combination of traditional Chinese and Western medicine intervention schemes.

[0092] In some embodiments, the estimated intervention effect can be determined by longitudinally comparing the pre-intervention indicators of the same target user with the simulated post-intervention indicators of a simulated combination of pre-defined traditional Chinese and Western medicine intervention programs, to identify the more effective target pre-defined combination of traditional Chinese and Western medicine intervention programs. Thus, by horizontally comparing the target pre-defined traditional Chinese medicine intervention program and the target pre-defined Western medicine intervention program combination with the best simulated intervention effect, a target pre-defined combination of traditional Chinese and Western medicine intervention programs can be obtained, thereby forming a comprehensive traditional Chinese and Western medicine intervention program.

[0093] For example, taking hypertension of the liver-yang hyperactivity type as an example, if the intervention goal is blood pressure control and relief of TCM syndromes, the intervention effect can be quantitatively evaluated by the difference in indicator improvement or its improvement rate before and after the intervention. In one example, for Western medicine indicators, criteria for judging the improvement value can be set, such as the improvement rate being the ratio of the reduction in systolic / diastolic blood pressure to the pre-intervention systolic / diastolic blood pressure. An improvement rate ≥20% is considered "significant effect," 10%~20% is "good effect," 5%~10% is "moderate effect," and <5% is "ineffective," etc. In another example, for TCM syndromes, the intervention effect can be evaluated based on the improvement value / improvement rate of the score.

[0094] For example, the regulatory effect of the intervention on the pathological mechanism can be evaluated by comparing the levels of core targets (such as ACE, AT1R, and β1 receptors) and the activity of core pathways (such as the RAAS pathway and the sympathetic pathway) before and after the intervention.

[0095] For example, the above assessment methods can be transformed into a unified comprehensive intervention effect score through methods such as weighted summation. For example, the comprehensive intervention effect score = blood pressure improvement effect score (40%) + syndrome improvement effect score (30%) + target regulation effect score (15%) + safety score (15%), etc.

[0096] In other embodiments, a horizontal comparison can be made between the preset combination of traditional Chinese and Western medicine intervention programs and at least one historical combination of traditional Chinese and Western medicine intervention programs implemented by other individual users / groups. These other individual users / groups have the same disease combination type information as the target user.

[0097] For example, target users A and B both have hypertension due to liver yang hyperactivity and have similar physiological data (such as gender, age, weight, blood pressure level, etc.). The improvement rate of target user A before and after the implementation of the preset combination of traditional Chinese and Western medicine intervention plan C1 is A1, and the improvement rate of target user B before and after the implementation of the historical combination of traditional Chinese and Western medicine intervention plan C2 is A2. Since A2>A1, C2 can be used as a reference for target user A. By simulating the implementation of C2 in A, the improvement rate A3 can be obtained. Then, it is determined whether A3>A2. Therefore, compared with simply relying on the search of the preset combination of traditional Chinese and Western medicine intervention plan, the efficiency of obtaining the optimal solution can be improved.

[0098] In some embodiments, as previously exemplified, the simulation implementation module 142 can be implemented using a machine learning model (such as a traditional learning model or a deep neural network model), the accuracy of which depends on the number of accurate training samples. In a further embodiment, the integrated traditional Chinese and Western medicine intervention decision-making system may further include a post-training module 170, which is used to obtain the actual intervention results (such as post-intervention indicators) of the target user implementing the target integrated traditional Chinese and Western medicine intervention plan, in order to form training data to train the simulation implementation module 142. As an example, the post-training module may be connected to the data acquisition module 110 to obtain the actual intervention results from the communication interface, input interface, or audio / video acquisition device of the data acquisition module 110.

[0099] Back Figure 1 The output module 150 is used to output the recommended integrated traditional Chinese and Western medicine intervention plan, so as to determine the target integrated traditional Chinese and Western medicine intervention plan for implementation by the target user. In some embodiments, there may be one or more recommended integrated traditional Chinese and Western medicine intervention plans. When there are multiple plans, they can be displayed in a list, and the user can select one of them as the target integrated traditional Chinese and Western medicine intervention plan.

[0100] In some embodiments, such as Figure 3 As shown, the integrated traditional Chinese and Western medicine intervention decision-making system can be mounted on a cloud device such as a server 310, and connected to the user terminal 320 via local or remote network communication to display a human-computer graphical interface on the monitor of the user terminal 320. The recommended integrated traditional Chinese and Western medicine intervention plans can be displayed on the human-computer interface for the user to select a target integrated traditional Chinese and Western medicine intervention plan. The user can be a physician or a patient seeking medical treatment. In some embodiments, the user terminal 320 can be implemented as a desktop computer or a mobile terminal, including but not limited to laptops, smartphones, or tablets.

[0101] In some embodiments, after the recommended integrated traditional Chinese and Western medicine intervention program is first implemented on the target user, the data acquisition module can periodically acquire updated physiological state data of the target user after the intervention, so as to obtain an updated recommended integrated traditional Chinese and Western medicine intervention program through the integrated traditional Chinese and Western medicine intervention decision system. In this way, the new recommended integrated traditional Chinese and Western medicine intervention program can be dynamically adjusted according to the user's physiological state, improving the intervention effect and efficiency for the target user.

[0102] To illustrate the above principles more intuitively, please refer to... Figure 4 The diagram illustrates the data flow in an application scenario of the integrated traditional Chinese and Western medicine intervention decision-making system in one embodiment of this disclosure.

[0103] exist Figure 4 The example demonstrates the collection of "physiological state data to be analyzed" from target users. This "physiological state data to be analyzed" includes both "Western medicine physiological state data to be analyzed" and "Traditional Chinese medicine physiological state data to be analyzed." The "physiological state data to be analyzed" can be converted into a "standardized feature vector" form through quantization and semantic analysis methods mentioned in previous examples.

[0104] Based on the standardized feature vectors and the corresponding "reasoning rules" obtained through the TCM dialectical knowledge graph and Western medicine diagnostic knowledge graph, "TCM syndrome information to be analyzed" and "Western medicine disease information to be analyzed" are derived. The "TCM syndrome information to be analyzed" can be quantified as "syndrome type and its integral or index" (or "syndrome index"), and the "Western medicine disease information to be analyzed" can be quantified as "disease type and its integral or index". Combining the "Western medicine disease information to be analyzed" and the "TCM syndrome information to be analyzed" yields "integrated TCM and Western medicine diagnostic information to be analyzed".

[0105] Based on the "integrated Chinese and Western medicine diagnostic information to be analyzed", highly correlated "target key points / channels" are identified in the "fusion biological network", and "preset Western medicine intervention program group" and "preset Chinese medicine intervention program group" with high correlation with the "target key points / channels" are identified.

[0106] The simulation results of various "preset combinations of traditional Chinese and Western medicine interventions" formed by the "preset Western medicine intervention group" and the "preset traditional Chinese medicine intervention group" are implemented on target users. The "simulated intervention effect" is determined based on the simulated intervention results. One or more "targeted preset combinations of traditional Chinese and Western medicine interventions" are selected based on the "simulated intervention effect" to form a corresponding number of "recommended integrated traditional Chinese and Western medicine intervention programs". The selection method based on the "simulated intervention effect" includes, but is not limited to, the longitudinal comparison and / or horizontal comparison mentioned in the previous embodiments.

[0107] Output "Recommended Integrated Traditional Chinese and Western Medicine Intervention Plans" for selecting "Target Integrated Traditional Chinese and Western Medicine Intervention Plan".

[0108] Updated physiological state data of target users after the implementation of the "Target Integrated Traditional Chinese and Western Medicine Intervention Program" is collected. The above process is repeated based on the updated physiological state data to obtain an updated recommended integrated traditional Chinese and Western medicine intervention program. Optionally, the "updated physiological state data" is used as the actual intervention result, and the improvement is compared with the pre-intervention physiological state data to obtain the "actual intervention effect" for reference. Furthermore, the pre- and post-intervention physiological state data and the "Target Integrated Traditional Chinese and Western Medicine Intervention Program" can be used to construct training data for the model implementing the above simulation.

[0109] It should be noted that, in Figure 1 , Figure 2 The various functional modules in the embodiments can be implemented, in whole or in part, by software, hardware, firmware, or any combination thereof. When implemented in software, they can be implemented, in whole or in part, in the form of a computer program or instruction product. A computer program or instruction product includes one or more computer programs or instructions. When a computer program or instruction is loaded and executed on a computer, it produces, in whole or in part, the flow or function according to this disclosure. The computer can be a general-purpose computer, a special-purpose computer, a computer network, or other programmable device. The computer program or instructions can be stored in a computer-readable storage medium or transferred from one computer-readable storage medium to another.

[0110] Furthermore, in Figure 1 , Figure 2 In practice, other module division methods can be used to achieve this. The device embodiments shown above are merely illustrative. For example, the module division described is only a logical functional division. In actual implementation, there may be other division methods. For example, a group of modules or modules may be combined or dynamically integrated into another system, or some features may be ignored or not executed. Furthermore, the coupling or direct coupling or communication connection shown or discussed may be through some interfaces. The indirect coupling or communication connection between devices or modules may be electrical or other forms.

[0111] In addition, Figure 1 , Figure 2 The functional modules and sub-modules in the embodiments can be dynamically integrated within a single processing unit, or each module can exist physically independently, or two or more modules can be dynamically integrated within a single unit. These dynamic units can be implemented in hardware or as software functional modules. If these dynamic units are implemented as software functional modules and sold or used as independent products, they can also be stored in a computer-readable storage medium. This storage medium can be a read-only memory, a hard disk, or an optical disk, etc.

[0112] like Figure 5 The diagram shown illustrates the structure of a computer device according to an embodiment of the present disclosure.

[0113] The computer device 500 may be exemplified as a processing terminal, such as a server, desktop computer, laptop computer, tablet computer, smartphone, or other terminal.

[0114] The computer device 500 includes a bus 501, a processor 502, and a memory 503. The processor 502 and the memory 503 can communicate with each other via the bus 501. The memory 503 can store computer programs or instructions. The processor 502 implements the functions of the functional modules in the integrated traditional Chinese and Western medicine intervention decision-making system of this embodiment by running the computer programs or instructions in the memory 503.

[0115] Bus 501 can be a Peripheral Component Interconnect (PCI) bus or an Extended Industry Standard Architecture (EISA) bus, etc. Buses can be categorized as address buses, data buses, control buses, etc. For ease of representation, although only one thick line is used in the diagram, this does not indicate that there is only one bus or one type of bus.

[0116] In some embodiments, processor 502 may be implemented as a central processing unit (CPU), microprocessor unit (MCU), system on chip (System on Chip), or field-programmable array (FPGA). Memory 503 may include volatile memory for temporary data storage during program execution, such as random access memory (RAM).

[0117] The memory 503 may also include non-volatile memory for data storage, such as read-only memory (ROM), flash memory, hard disk drive (HDD), or solid-state disk (SSD).

[0118] In some embodiments, the computer device 500 may further include a communicator 504. The communicator 504 is used for communication with external devices. In specific examples, the communicator 504 may include one or more wired and / or wireless communication circuit modules. For example, the communicator 504 may include one or more of, such as a wired network card, a USB module, a serial interface module, etc. The wireless communication protocols followed by the wireless communication module include, for example, Nearfield Communication (NFC) technology, Infrared (IR) technology, Global System for Mobile Communications (GSM), General Packet Radio Service (GPRS), Code Division Multiple Access (CDMA), Wideband Code Division Multiple Access (WCDMA), Time-Division Code Division Multiple Access (TD-SCDMA), Long Term Evolution (LTE), Bluetooth (BT), Global Navigation Satellite System (GNSS), etc.

[0119] This disclosure also provides a computer-readable storage medium storing a computer program or instructions, which, when executed, implements the functions of the functional modules in the integrated traditional Chinese and Western medicine intervention decision-making system of this disclosure.

[0120] That is, the method steps in the above embodiments are implemented as software or computer code that can be stored in a recording medium (such as CD ROM, RAM, floppy disk, hard disk or magneto-optical disk), or implemented as computer code that is originally stored in a remote recording medium or a non-transitory machine-readable medium and will be stored in a local recording medium after being downloaded via a network, so that the method represented herein can be stored in such software processing on a recording medium using a general-purpose computer, a special processor or programmable or special hardware (such as ASIC or FPGA).

[0121] This disclosure may also provide a computer program product, one or more computer programs or instructions, which, when run, perform all or part of the functions of the functional modules in the integrated traditional Chinese and Western medicine intervention decision-making system of this disclosure. The computer program product includes one or more computer programs or instructions.

[0122] Computer programs or instructions can be stored in a readable storage medium or transferred from one readable storage medium to another. For example, the computer program or instructions can be transferred from one website, computer, server, or data center to another website, computer, server, or data center via wired or wireless means. The readable storage medium can be any available medium capable of access, or a data storage device such as a server or data center that integrates one or more available media. The available medium can be a magnetic medium, such as a floppy disk, hard disk, or magnetic tape; an optical medium, such as a digital video optical disc; or a semiconductor medium, such as a solid-state drive. The computer-readable storage medium can be a volatile or non-volatile storage medium, or it can include both volatile and non-volatile types of storage media.

[0123] In summary, this disclosure relates to the field of computer technology and provides a comprehensive TCM-Western medicine intervention decision-making system, comprising: a data acquisition module for collecting physiological state data of a target user to be analyzed; a diagnostic reasoning module for obtaining TCM syndrome information and Western medicine disease information based on the TCM physiological state data and Western medicine pathological state data to be analyzed, and obtaining comprehensive TCM-Western medicine diagnostic information; a multi-omics mapping module for mapping pathological mechanism information based on the TCM syndrome information to be analyzed; a fusion network module for constructing / calling a fusion biological network corresponding to each preset comprehensive TCM-Western medicine diagnostic information; an intervention decision-making module for determining a recommended comprehensive TCM-Western medicine intervention plan from preset TCM intervention plan groups and preset Western medicine intervention plan groups associated with the target key target / channel based on the prediction of the synergistic intervention effect of TCM and Western medicine; and an output module for outputting the recommended comprehensive TCM-Western medicine intervention plan. The system integrates the Western medicine micro-model and the TCM macro-model according to feature mapping, thereby obtaining a precise recommendation of comprehensive TCM-Western medicine intervention plan, effectively solving the problems in related technologies.

[0124] The above embodiments are merely illustrative of the principles and effects of this disclosure and are not intended to limit this disclosure. Any person skilled in the art can modify or alter the above embodiments without departing from the spirit and scope of this disclosure. Therefore, all equivalent modifications or alterations made by those skilled in the art without departing from the spirit and technical concept disclosed in this disclosure should still be covered by the protection scope of this disclosure.

Claims

1. A decision-making system for integrated traditional Chinese and Western medicine intervention, characterized in that, include: The data acquisition module is used to collect physiological state data of the target user to be analyzed, including traditional Chinese medicine physiological state data and Western medicine physiological state data to be analyzed. The diagnostic reasoning module is used to obtain the TCM syndrome information and the Western medicine disease information to be analyzed based on the TCM physiological state data and the Western medicine physiological state data to be analyzed, respectively, and to obtain the TCM and Western medicine comprehensive diagnostic information of the target user by combining the TCM syndrome information and the Western medicine disease information. A multi-omics mapping module is used to form a preset syndrome-pathology mapping relationship between preset pathological information representing preset TCM syndrome information and preset Western medicine disease information; wherein, the preset syndrome-pathology mapping relationship is established based on the correlation between preset TCM syndrome information and preset pathological information in terms of signs and / or symptoms; the preset TCM syndrome information is associated with each preset TCM intervention program with intervention effect, and the target / pathway corresponding to the preset pathological information is associated with each preset Western medicine intervention program with intervention effect. The fusion network module is used to construct / call a fusion biological network corresponding to each preset integrated traditional Chinese and Western medicine diagnostic information; wherein, the fusion biological network is obtained from the known biological network corresponding to the preset integrated traditional Chinese and Western medicine diagnostic information, and the association between the target / pathway in the known biological network and the corresponding preset intervention plan; The intervention decision module is used to respond to the target key target / channel matched in the fused biological network based on the integrated TCM and Western medicine diagnostic information to be analyzed, and to determine the recommended integrated TCM and Western medicine intervention plan from the preset TCM intervention plan group and the preset Western medicine intervention plan group associated with the target key target / channel based on the prediction of the TCM and Western medicine synergistic intervention effect. The output module is used to output the recommended integrated traditional Chinese and Western medicine intervention plan, so as to determine the target integrated traditional Chinese and Western medicine intervention plan for implementation by the target user.

2. The integrated traditional Chinese and Western medicine intervention decision-making system according to claim 1, characterized in that, The Western medicine physiological state data to be analyzed includes at least one of the following: vital sign data of the target user collected by physiological state sensors; Western medicine examination / test index data; Western medicine diagnostic result data; The TCM physiological state data to be analyzed includes at least one of the following: data collected from the four diagnostic methods of TCM; and TCM syndrome data.

3. The integrated traditional Chinese and Western medicine intervention decision-making system according to claim 1, characterized in that, include: The quantization module is used to quantify the physiological state data to be analyzed and convert it into a standardized feature vector, which is then output to the diagnostic reasoning module.

4. The integrated traditional Chinese and Western medicine intervention decision-making system according to claim 1, characterized in that, include: The data acquisition module is also used to acquire the physiological state data updated after the target integrated traditional Chinese and Western medicine intervention plan is implemented on the target user, so as to obtain the updated recommended integrated traditional Chinese and Western medicine intervention plan through the integrated traditional Chinese and Western medicine intervention decision system.

5. The integrated traditional Chinese and Western medicine intervention decision-making system according to claim 1, characterized in that, Constructing integrated biological networks, including: Identify known biological networks; Establish the association between a pre-defined set of Western medicine intervention protocols and its first set of targets / pathways with known effects in the known biological network; Establish the association between a pre-defined set of TCM intervention protocols and a second set of targets / pathways with known functions in known biological networks; By integrating the aforementioned relationships into the known biological network, a fused biological network is obtained.

6. The integrated traditional Chinese and Western medicine intervention decision-making system according to claim 1, characterized in that, The intervention decision-making module includes: The intervention plan determination module is used to determine, based on the fused biological network, a set of preset traditional Chinese medicine intervention plans and a set of preset Western medicine intervention plans associated with the target key target / channel; The simulation implementation module is used to obtain a preset combination of traditional Chinese medicine and Western medicine intervention schemes selected from the preset group of traditional Chinese medicine intervention schemes and the preset group of Western medicine intervention schemes, and to simulate the results of implementing the preset combination of traditional Chinese medicine and Western medicine intervention schemes on the target user. The effect evaluation module is used to evaluate the intervention effect based on the simulated intervention results, and determine the target preset combination of traditional Chinese and Western medicine intervention schemes based on the condition that the synergistic intervention effect is better, so as to obtain the recommended integrated traditional Chinese and Western medicine intervention scheme based on the target preset combination of traditional Chinese and Western medicine intervention schemes.

7. The integrated traditional Chinese and Western medicine intervention decision-making system according to claim 6, characterized in that, The pre-set TCM intervention program group was obtained based on screening various pre-set TCM intervention programs that showed synergistic effects with the pre-set Western medicine intervention program group on key target points / pathways.

8. The integrated traditional Chinese and Western medicine intervention decision-making system according to claim 6, characterized in that, The method for determining the target pre-set combination of traditional Chinese and Western medicine interventions based on the condition of better synergistic intervention effects includes: 1) Conduct a longitudinal comparison of the intervention effects of the preset combination of traditional Chinese and Western medicine intervention programs with at least one historical combination of traditional Chinese and Western medicine intervention programs already implemented by the target user; 2) Compare the preset combination of traditional Chinese and Western medicine intervention programs with at least one historical combination of traditional Chinese and Western medicine intervention programs implemented by other individual users / groups; the other individual users / groups have the same disease combination type information as the target user.

9. The integrated traditional Chinese and Western medicine intervention decision-making system according to claim 6, characterized in that, The preset TCM intervention group and / or preset Western medicine intervention group also include non-drug programs.

10. The integrated traditional Chinese and Western medicine intervention decision-making system according to claim 6, characterized in that, The simulation implementation module is implemented based on a machine learning model; The integrated traditional Chinese and Western medicine intervention decision-making system also includes a post-training module, which is used to obtain the actual intervention results of the target user implementing the target integrated traditional Chinese and Western medicine intervention plan, so as to form training data to train the simulation implementation module.

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