A gynecological tumor tissue separation and recovery device
By employing a closed collection hood with suction cups and a three-stage separation technique in the gynecological tumor tissue separation and recovery device, the problems of complex structure and sample loss of existing devices have been solved, achieving efficient and safe tumor tissue collection and separation, which is suitable for minimally invasive surgery.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- FOURTH MILITARY MEDICAL UNIVERSITY
- Filing Date
- 2026-02-05
- Publication Date
- 2026-06-09
AI Technical Summary
Existing gynecological tumor tissue separation and recovery devices are complex in structure and cumbersome to operate. They lack a closed collection structure that can directly adhere to the surgical wound, making it impossible to avoid the splashing and diffusion of tumor tissue fragments and cells, resulting in the loss of pathological samples. Furthermore, their ability to capture small tissue fragments and tumor cells is limited, making it difficult to coordinate with minimally invasive surgical instruments.
The system uses a collection hood with suction cups that fits snugly against the wound to form a closed collection space. It combines a three-stage separation method of filtration, centrifugation, and atomization, and achieves closed collection and efficient separation of tumor tissue through negative pressure suction and a power component. It has a high degree of integration and is suitable for minimally invasive surgery.
It significantly reduces the risk of tumor cell splashing and spread, improves sample purity and recovery rate, simplifies the operation process, and enables synergistic use with minimally invasive surgical instruments to meet clinical needs.
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Figure CN122163295A_ABST
Abstract
Description
Technical Field
[0001] This invention relates to the field of medical device technology, specifically to a device for separating and recovering gynecological tumor tissue. Background Technology
[0002] Gynecologic oncology surgery is a core medical approach for treating gynecologic tumors such as uterine fibroids, ovarian cysts, and cervical cancer. Its core objective is to maximize the removal of tumor tissue while preserving the patient's reproductive function and normal physiological structure, reducing the risk of tumor recurrence and metastasis. With the rapid development of minimally invasive medical techniques, laparoscopy, hysteroscopy, and transvaginal minimally invasive surgery have become the mainstream surgical methods for treating gynecologic tumors. These surgeries have significant advantages such as smaller incisions, less bleeding, and faster postoperative recovery, greatly reducing surgical trauma and the risk of postoperative complications. During minimally invasive gynecologic oncology surgery, the collection and recovery of tumor tissue is a crucial prerequisite for subsequent pathological examination, disease diagnosis, and optimization of treatment plans. During surgery, doctors typically use energy instruments such as ultrasonic scalpels to cut the tumor tissue. This cutting process generates a large amount of tumor tissue fragments, along with blood exudate and tissue fluid, forming a mixture of tumor tissue and fluid. If this mixture is not collected promptly and effectively, it can lead to tumor cell splatter and spread, increasing the risk of iatrogenic implantation and threatening postoperative recovery. Furthermore, it can cause the loss of tumor tissue samples, affecting the accuracy and completeness of subsequent pathological examinations, potentially leading to misdiagnosis and impacting treatment outcomes.
[0003] Application No. 202210682991.0 discloses a gynecological tumor tissue separation and recovery device, comprising a separation and recovery main body, an outer cylinder, a rotating shaft, a connecting ring, a primary filtration mechanism, a drain switch, multiple fan blade groups, a control mechanism, and an unlocking mechanism. Each fan blade group includes an inner fan blade and an outer fan blade. When stirring is required, the outer cylinder is filled with water, the water level exceeding the multiple fan blade groups. When the fan blade groups rotate counterclockwise, they descend due to water resistance, stirring and rinsing the tumor. The unlocking mechanism is configured to release the control mechanism's restriction on the inner fan blades during drainage after stirring and rinsing, allowing the inner fan blades to rotate about a horizontal axis extending radially along the connecting ring. Subsequently, when the connecting ring rises to a preset position, the control mechanism releases the restriction on the outer fan blades, allowing the outer fan blades to rotate about a horizontal axis extending radially along the connecting ring.
[0004] The aforementioned scheme has a complex overall structure and cumbersome operation steps. It also lacks a closed collection structure that directly adheres to the surgical wound, making it impossible to prevent the splashing and diffusion of tumor tissue fragments and cells at the source, resulting in the loss of a large number of valuable pathological samples. Moreover, the scheme mainly relies on stirring, rinsing, and filtration for separation, which has limited ability to capture small tissue fragments and tumor cells, resulting in unsatisfactory sample purity and recovery rate. In addition, the device is large in size and has low integration, making it inconvenient for real-time use in minimally invasive surgery and difficult to coordinate with instruments such as laparoscopes and hysteroscopes, thus limiting its widespread application in clinical settings. Summary of the Invention
[0005] To address the aforementioned problems, this invention aims to provide a gynecological tumor tissue separation and recovery device. This device can effectively collect and isolate tumor tissue mixtures from the wound site during minimally invasive gynecological surgery, preventing the splashing and diffusion of tumor tissue fragments and cells from the source and improving tissue collection rates. It enables efficient separation and recovery of tumor tissue, significantly improving sample purity and the accuracy of pathological examination. Furthermore, it can be used in conjunction with minimally invasive surgical instruments such as laparoscopes and hysteroscopes to achieve real-time, continuous tissue processing during surgery, meeting clinical requirements for high efficiency, safety, and reliability in tumor tissue separation and recovery.
[0006] The main idea of the technical solution adopted in this invention is as follows: This invention achieves intraoperative closed collection of tumor tissue mixtures by setting up a closed collection mechanism that fits in close to the surgical wound, avoiding the splashing and diffusion of tumor cells; at the same time, a multi-stage separation method combining filtration, centrifugation and nebulization capture is adopted in the separation and recovery mechanism to separate and recover tumor tissue step by step, improving sample purity and recovery rate; and through the coordinated setting of power components and drainage components, automated centrifugation, drainage and nebulization processing are realized, simplifying the operation process and improving the integration and clinical applicability of the device.
[0007] To achieve the above objectives, the technical solution adopted by the present invention is as follows: A device for separating and recovering gynecological tumor tissue, comprising: The collection device fits snugly against the wound; The separation and recovery mechanism, connected to the collection mechanism, is used to separate and recover the inhaled tumor tissue liquid mixture.
[0008] Furthermore, based on the above technical solutions, the collection mechanism includes: The collection cover has a collection port at the bottom, and suction cups are provided on the periphery of its lower surface; The collection chamber is located inside the collection hood, with a ring of liquid inlets in the middle; The flushing pipe is installed inside the collection hood.
[0009] Furthermore, based on the above technical solutions, the separation and recycling mechanism further includes: The outer cylinder has a negative pressure pump installed at the top and a filter plate installed inside. The inner cylinder is rotatably installed inside the outer cylinder, and its interior contains a power assembly and a drainage assembly. A centrifuge tube is fixedly installed on the inner cylinder, and its side wall has multiple centrifugation holes; The atomizing component is located at the bottom of the centrifuge cylinder and is slidably connected to the inner cylinder.
[0010] Furthermore, based on the above technical solutions, the power component further includes: The drive motor is located on the bottom surface of the outer cylinder; The support rod is connected to the output shaft of the drive motor at one end and to a displacement plate at the other end. The limiting rod is fixedly connected to the support rod, and its two ends are slidably connected to the limiting groove opened on the inner wall of the inner cylinder; The connecting rod is positioned above the displacement plate and is slidably connected to the support rod.
[0011] Furthermore, based on the above technical solutions, the drainage component further includes: A drain pipe is connected and installed below the displacement plate; The flexible hose is connected to the drain pipe at one end and passes through the inner cylinder at the other end. The outer ring is located on the inner bottom side of the flexible hose; The inner ring is located on the inner top side of the telescopic hose and is configured to cooperate with the outer ring.
[0012] Furthermore, based on the above technical solutions, the atomizing component further includes: The atomizing tube is fitted onto the outside of the inner tube, and multiple capturing plates are installed on its inner wall; An atomizing plate is located above the atomizing cylinder, and multiple atomizers are mounted on it; The atomizing curve is located between the atomizing cylinder and the inner cylinder.
[0013] The beneficial effects of this invention are: This invention, by setting up a collection hood with suction cups, can form a closed collection space with the wound surface, blocking the splashing of tumor tissue fragments and cells from the source, reducing the risk of iatrogenic implantation. Furthermore, the combination of the guide slope and flushing tube inside the collection hood and negative pressure suction can thoroughly flush the wound and the inner wall of the collection hood, fully collecting small tissue fragments and significantly reducing sample loss.
[0014] This invention employs a three-stage progressive separation process—filtration, centrifugation, and nebulization—to recover tumor tissue. First, a filter plate pre-filters the mixture, intercepting larger tissue debris to prevent clogging and improve subsequent separation efficiency. Then, a centrifuge cylinder rotates at high speed driven by a power unit, utilizing the density difference between tumor tissue and liquid to eject and collect heavier tumor tissue fragments through the centrifuge orifices, achieving efficient liquid-solid separation. Finally, the nebulization unit atomizes the high-concentration cytoplasm obtained from centrifugation, using inertial impaction to adhere tiny tumor cells to a capture plate, achieving precise capture of small tissue fragments and cells. This improves sample purity and recovery rate, reduces sample loss, and provides more complete and reliable tissue samples for pathological examination.
[0015] The collection mechanism and separation and recovery mechanism of this invention are connected by a drainage tube. It is small in size and has a reasonable layout, making it easy to move and operate in the limited space of the operating room. It can also be used in conjunction with minimally invasive surgical instruments such as laparoscopes and hysteroscopes to achieve real-time and continuous tissue collection and separation during surgery. Attached Figure Description
[0016] Figure 1 This is a schematic diagram of the overall structure of the present invention; Figure 2 This is a schematic diagram showing the cooperation relationship between the ultrasonic scalpel and the collection mechanism of the present invention; Figure 3 This is a schematic cross-sectional view of the collection mechanism of the present invention; Figure 4 This is a schematic cross-sectional view of the separation and recovery mechanism of the present invention; Figure 5 This is a schematic diagram of the separation and recycling mechanism of the present invention without the outer cylinder; Figure 6 This is a schematic diagram showing the connection relationship between the centrifuge cylinder and the inner cylinder of the present invention; Figure 7 For the present invention Figure 6 A schematic diagram of the cross-sectional structure; Figure 8 This is a schematic diagram showing the cooperation relationship between the power component and the drainage component of the present invention; Figure 9 This is a schematic diagram showing the connection relationship between the outer ring and the inner ring of the present invention; Figure 10 For the present invention Figure 9 Another perspective structural diagram; Figure 11 This is a schematic diagram of the atomizing component structure of the present invention; Figure 12 This is a schematic diagram of the internal structure of the atomizing cylinder of the present invention.
[0017] The components include: 1. Collection mechanism; 11. Collection hood; 111. Collection port; 112. Suction cup; 113. Connection port; 12. Collection chamber; 121. Liquid inlet; 122. Liquid outlet; 123. Drainage pipe; 13. Flushing pipe; 131. Flushing hole; 2. Separation and recovery mechanism; 3. Outer cylinder; 31. Negative pressure pump; 32. Filter plate; 4. Inner cylinder; 41. Limiting groove; 5. Power assembly; 51. Drive motor; 52. Support rod; 53. Displacement plate; 54. Limiting rod; 55. Connecting rod; 6. Drainage assembly; 61. Drainage pipe; 62. Telescopic hose; 63. Outer ring; 64. Inner ring; 65. Drainage chamber; 66. Water outlet pipe; 7. Centrifuge cylinder; 71. Centrifuge hole; 72. Centrifuge plate; 8. Atomizing assembly; 81. Atomizing cylinder; 811. Capture plate; 82. Atomizing plate; 821. Atomizer; 83. Atomizing bend. Detailed Implementation
[0018] To make the objectives, technical solutions, and advantages of the embodiments of this application clearer, the technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, and not all embodiments. The components of the embodiments of this application described and shown in the accompanying drawings can generally be arranged and designed in various different configurations.
[0019] The inventors discovered that existing gynecological tumor tissue separation and recovery devices have complex overall structures and cumbersome operation steps. They also lack a closed collection structure that directly adheres to the surgical wound, making it impossible to prevent the splashing and diffusion of tumor tissue fragments and cells at the source, resulting in the loss of a large number of valuable pathological samples. Moreover, the above-mentioned methods mainly rely on stirring, rinsing, and filtering for separation, which has limited ability to capture small tissue fragments and tumor cells, resulting in unsatisfactory sample purity and recovery rate. In addition, the device is large in size and has low integration, making it inconvenient for real-time use in minimally invasive surgery and difficult to coordinate with instruments such as laparoscopes and hysteroscopes, thus limiting its widespread application in clinical settings.
[0020] Based on the above findings, this application proposes a gynecological tumor tissue separation and recovery device, which can enclose and collect tumor tissue mixtures at the wound site during minimally invasive gynecological surgery, avoiding the splashing and diffusion of tumor tissue fragments and cells from the source and improving the tissue collection rate; it can achieve efficient separation and recovery of tumor tissue, significantly improving sample purity and the accuracy of pathological examination; it can be used in conjunction with minimally invasive surgical instruments such as laparoscopes and hysteroscopes to achieve real-time and continuous tissue processing during surgery, meeting the clinical requirements for high efficiency, safety and reliability in tumor tissue separation and recovery. Example
[0021] See Figures 1-7This application discloses a gynecological tumor tissue separation and recovery device, used in gynecological minimally invasive surgeries, such as laparoscopy, hysteroscopy, or transvaginal minimally invasive surgery, to collect, separate, and recover the mixture of tumor tissue and irrigation fluid / exudate at the wound site for subsequent pathological examination and processing. The gynecological tumor tissue separation and recovery device described in this embodiment includes a collection mechanism 1 and a separation and recovery mechanism 2.
[0022] The collection mechanism 1 is designed to fit into the wound to form a relatively enclosed collection space, thereby preventing tumor tissue fluid from splashing out during surgery and collecting it. It includes a collection cover 11, a collection chamber 12, and an irrigation tube 13.
[0023] Specifically, the collection cover 11 has a conical structure with a collection port 111 at the bottom for aligning with the wound area. Multiple suction cups 112 are arranged around the lower surface of the collection cover 11. These suction cups 112 are preferably annular silicone suction cups, which form a sealed fit when the collection cover 11 is pressed against the body surface or the surface of the cavity tissue, reducing air and fluid leakage and ensuring the stability of subsequent negative pressure suction. A connection port 113 is also provided at the top of the collection cover 11 for inserting surgical instruments, such as an ultrasonic scalpel or an irrigation tube 13.
[0024] The collection hood 11 has a ring of guide slope inside, which together with the inner wall of the collection hood 11 form a collection cavity 12. The collection cavity 12 has multiple liquid inlets 121 on the side near the collection port 111, and a liquid outlet 122 on one side of the collection cavity 12. The liquid outlet 122 is connected to the separation and recovery mechanism 2 through a guide pipe 123 to transport the collected mixture to the separation and recovery mechanism 2 for subsequent processing.
[0025] The irrigation tube 13 is inserted inside the collection hood 11. One end of the tube can extend into the collection chamber 12 near the wound, and the other end can be connected to an external irrigation fluid source, such as a saline bag or an infusion pump. The irrigation tube 13 is used to deliver irrigation fluid to the wound area to moisten the tissue, reduce the risk of tissue adhesion, and form an aspirable mixture with the detached tumor tissue fragments along with the irrigation fluid.
[0026] Preferably, multiple flushing holes 131 are provided above and below the outlet end of the flushing tube 13. The flushing hole 131 located above is used to spray the flushing liquid in a diffused manner to flush the tumor tissue fragments that splashed onto the inner wall of the collection hood 11 during the operation. The flushing hole 131 located below is used to flush the lesion site. The flushed liquid and tissue fragments enter the collection chamber 12 together through the inlet 121.
[0027] It should be noted that during surgery, the collection port 111 is aligned with the target wound area, and the collection cover 11 is pressed to make the suction cup 112 adhere to the tissue surface, forming a locally enclosed collection space. Then, the ultrasonic scalpel used to cut the tumor is inserted through the connection port 113 of the collection cover 11 to cut the tumor tissue. When the fluid and tissue fragments generated during cutting splash, the collection cover 11 can effectively block and collect them, preventing the spread of tumor cells and improving the tissue collection rate.
[0028] After the surgery, when it is necessary to clean the wound, the ultrasonic scalpel is removed, and the irrigation tube 13 is inserted into the collection cover 11 through the connection port 113, with its outlet end near the wound. Then, the external irrigation fluid source is activated, and the irrigation fluid is sprayed out through the irrigation hole 131 of the irrigation tube 13 to thoroughly rinse the wound surface and the inner wall of the collection cover 11, bringing residual tumor tissue fragments, blood, and exudate into the collection chamber 12.
[0029] Next, the separation and recovery mechanism 2 is connected to the collection mechanism 1 through the drainage tube 123, and is used to separate and recover the inhaled mixture and tumor tissue. It includes an outer cylinder 3, an inner cylinder 4, a centrifuge cylinder 7, a power component 5, a drainage component 6, and an atomizing component 8.
[0030] The outer cylinder 3 is a cylindrical hollow cavity with three triangularly distributed support legs at its bottom. A cover is mounted on top of the outer cylinder 3, and a negative pressure pump 31 is bolted to the outside of the cover. The negative pressure pump 31 is a miniature oil-free vacuum pump. One end of the negative pressure pump 31 is connected to the drainage pipe 123, and the other end is connected to the inside of the outer cylinder 3 through a negative pressure pipeline. This provides negative pressure driving force for the entire device, allowing the mixture to be drawn from the collection mechanism 1 into the outer cylinder 3 through the inlet 121. A negative pressure gauge and a pressure regulating valve are installed on the negative pressure pipeline for real-time monitoring and adjustment of the negative pressure value inside the outer cylinder.
[0031] A filter plate 32 is horizontally installed in the upper middle part of the outer cylinder 3 via an installation rod. The filter plate 32 is integrally formed and connected to the cover via the installation rod, and is slidably connected to the inner wall of the outer cylinder 3. Multiple filter holes are evenly opened on the filter plate 32 for preliminary filtration of the separated liquid and interception of larger tissue debris impurities.
[0032] The inner cylinder 4 is a cylindrical hollow cavity, coaxially rotatable inside the outer cylinder 3, and located below the filter plate 32. A rotating bushing is provided at the center of the bottom of the inner cylinder 4, which is rotatably connected to the bottom surface of the outer cylinder 3 through a bearing to achieve stable rotation of the inner cylinder 4.
[0033] The centrifuge cylinder 7 is a cylindrical structure with an open top and a closed bottom. Its lower end is fixedly fitted onto the upper middle part of the inner cylinder 4, arranged coaxially with the inner cylinder 4, and rotates synchronously with it. The centrifuge cylinder 7 is located below the filter plate 32 and is used to receive the filtered liquid and further centrifuge it. Preferably, the side wall of the centrifuge cylinder 7 has a plurality of square centrifuge holes 71 evenly distributed, and centrifuge plates 72 are hinged to the centrifuge holes 71. When the inner cylinder 4 drives the centrifuge cylinder 7 to rotate, because tumor tissue is heavier than liquid, the resultant force of centrifugal force acting on the tumor fragments and liquid is significantly different. The centrifugal inertial force on the tumor fragments is much greater than that on the liquid, which in turn pushes the centrifuge plate 72 at the centrifuge hole 71 to flip outward, opening the centrifuge hole 71. The tumor fragments are thrown out through the opened centrifuge hole 71 and fall into the gap between the centrifuge cylinder 7 and the outer cylinder 3. The liquid, being lighter, does not experience enough centrifugal force to open the centrifuge plate 72 and remains inside the centrifuge cylinder 7. As the centrifugation process continues, the tumor fragments are continuously separated and collected, resulting in a high concentration of cell plasma. After centrifugation, the inner cylinder 4 stops rotating, the centrifuge plate 72 automatically resets, and the centrifuge hole 71 is resealed to prevent residual liquid in the centrifuge cylinder 7 from flowing out of the centrifuge hole 71.
[0034] Furthermore, the power assembly 5 is disposed inside the inner cylinder 4 and is used to provide power for the rotation and centrifugal force of the inner cylinder 4. It includes a drive motor 51, a support rod 52, a displacement plate 53, a limiting rod 54, and a connecting rod 55.
[0035] Specifically, the drive motor 51 is a stepper motor, model 57HS22, which is mounted on the center of the bottom surface of the outer cylinder 3 via a motor bracket, with the motor output shaft facing upwards and coaxially arranged with the inner cylinder 4.
[0036] The support rod 52 is a cylindrical hollow rod. One end is splinedly connected to the output shaft of the drive motor 51 via a coupling, and the other end is fixedly connected to the center of the bottom surface of the displacement plate 53 via bolts, thus transmitting power. It is worth noting that because the support rod 52 is splinedly connected to the drive motor 51, the support rod 52 can undergo a certain degree of axial displacement relative to the output shaft of the drive motor 51. The displacement plate 53 is located at the top of the support rod 52, and a connecting rod 55 extends through it. One end of the connecting rod 55 is fixedly connected to the inner top wall of the inner cylinder 4, and the other end is slidably connected to the support rod 52.
[0037] The limiting rods 54 are symmetrically fixedly connected to both sides of the support rod 52. Two oblique limiting grooves 41 are symmetrically opened on the upper and lower sides of the inner wall of the inner cylinder 4. The two ends of the limiting rods 54 that are far apart from each other are embedded in the limiting grooves 41 on the inner wall of the inner cylinder 4 and are slidably connected with the limiting grooves 41. When the drive motor 51 rotates, the support rod 52 and the inner cylinder 4 are rotated synchronously, and the support plate 52 and the displacement plate 53 are guided to move axially along the inner cylinder 4.
[0038] Furthermore, the drainage assembly 6 is disposed inside the inner cylinder 4 and is used to discharge the liquid after centrifugal separation. It includes a drain pipe 61, a telescopic hose 62, an outer ring 63, and an inner ring 64.
[0039] One end of the drain pipe 61 is connected to the bottom of the displacement plate 53, and the other end is fixed to the bottom of the inner cylinder 4. The bottom of the inner cylinder 4 and the bottom surface of the outer cylinder 3 together form a drain cavity 65. The bottom of the drain cavity 65 is provided with a water outlet for connecting to the water outlet pipe 66 to drain the water inside the drain cavity 65.
[0040] The flexible hose 62 is made of corrugated pipe, which has good elasticity and corrosion resistance. One end of the flexible hose 62 is sealed to the upper end of the drain pipe 61 by a clamp, and the other end is installed through the top of the inner cylinder 4.
[0041] The outer ring 63 is a solid circle structure and is fixedly installed on the inner top side of the telescopic hose 62. The inner ring 64 is an annular structure and is fixedly installed on the inner bottom side of the telescopic hose 62. The two are configured to cooperate with each other. When the telescopic hose 62 is in the contracted state, the inner ring 64 and the outer ring 63 are tightly fitted to achieve a seal on the telescopic hose 62. When the telescopic hose 62 is in the extended state, the inner ring 64 and the outer ring 63 are separated, and the liquid can pass through smoothly. This is used to prevent liquid from being discharged during centrifugation and to drain the liquid when centrifugation is finished.
[0042] Furthermore, the atomizing component 8 is disposed at the bottom of the centrifuge cylinder 7 and is slidably connected to the inner cylinder 4, and is used to atomize the tumor tissue mixture separated by centrifugation to improve the tissue recovery rate. It includes an atomizing cylinder 81, an atomizing plate 82, and an atomizing bend 83.
[0043] Specifically, the atomizing cylinder 81 is a cylindrical sleeve structure, coaxially sleeved on the outside of the inner cylinder 4, and slidably connected to the inner cylinder 4. Multiple capture plates 811 are evenly arranged on the inner wall of the atomizing cylinder 81, and the capture plates 811 are fixed to the inner wall of the atomizing cylinder by adhesive bonding for adsorbing and capturing tumor tissue.
[0044] The atomizing plate 82 is horizontally positioned above the atomizing cylinder 81. Multiple atomizers 821 are evenly distributed on the atomizing plate 82. The atomizers 821 are ultrasonic atomizers, model MY-300. The atomizing plate 82 also has atomizing holes, with gas membranes at these holes allowing only atomized tissue particles to pass through. When the atomizer 821 atomizes the high-concentration cell plasma generated by centrifugation, the atomized gas-liquid mixture can pass through the gas membrane into the atomizing cylinder 81 and be captured by the capturing plate 811. The atomizing bend 83 is located in the gap between the atomizing cylinder 81 and the inner cylinder 4, forming a continuous S-shaped bend structure to guide the atomized gas-liquid mixture along a preset trajectory.
[0045] It is worth noting that when the high-concentration cytoplasm is atomized and enters the cell interception area, it passes through the chamber of multi-level baffles and curved channels. Due to their large mass and inertia, the cell particles cannot make sharp turns with the airflow and directly collide with and adhere to the special cell capture plate 811. The cell capture plate 811 and the gas membrane are integrated in the atomizing cylinder 81. After the process is completed, the atomizing cylinder 81 can be removed as a whole for testing. This process can transform the cell components from a liquid state into a solid sample that can be directly analyzed for pathology, thus completing the final dry-wet separation.
[0046] Application Examples This embodiment takes hysteroscopic myomectomy as an example of minimally invasive surgery. During the operation, the splashed fluid and tissue fragments are collected and processed. The steps are as follows: 1. Initial intraoperative data collection First, after completing the hysteroscopic puncture and establishing the operating channel, the surgeon precisely aligns the collection port 111 at the bottom of the collection cover 11 of the collection mechanism 1 with the wound area. Then, the ultrasonic scalpel used for tumor cutting is inserted into the collection space through the connection port 113 on the top of the collection cover 11 until it reaches the location of the uterine fibroid lesion. During the operation, the surgeon activates the ultrasonic scalpel to cut the uterine fibroid tissue. During the cutting process, tumor tissue fragments, blood exudate, and a small amount of tissue fluid will splash, and the splashed mixture is effectively blocked by the collection cover 11.
[0047] 2. Postoperative irrigation After the uterine fibroid tissue is cut off, the ultrasonic scalpel is turned off and removed from the connection port 113 of the collection cover 11. Then, the flushing tube 13 is inserted into the collection cover 11 through the connection port 113. The external infusion pump is started, and physiological saline is delivered to the outlet end through the flushing tube 13. It is sprayed out in a divergent manner through the upper and lower sets of flushing holes 131 to flush the lesion and the tumor tissue fragments splashed on the inner wall of the collection cover 11. The flushed mixture enters the collection chamber 12 through the inlet 121, and is then transported to the separation and recovery mechanism 2 through the drainage tube 123 under negative pressure.
[0048] 3. Preliminary filtration and centrifugal separation The mixture transported from the collection mechanism 1 to the outer cylinder 3 is first pre-filtered by the filter plate 32 before entering the centrifuge cylinder 7. The drive motor 51 is started, which drives the support rod 52 to rotate. At the same time, the limiting rod 54 slides obliquely in the limiting groove 41, thereby causing the support rod 52 to generate a certain axial displacement upward. At this time, the displacement plate 53 drives the telescopic hose 62 to shorten, so that the inner ring 64 in the telescopic hose 62 and the outer ring 63 are engaged and locked, and the liquid in the centrifuge cylinder 7 cannot be drained. Under the action of centrifugal force, the tumor tissue fragments inside the centrifuge cylinder 7 push open the centrifuge plate 72 and are discharged into the cylinder gap to form a high-concentration slurry, and the liquid remains inside the centrifuge cylinder 7.
[0049] 4. Atomization capture The nebulizer 821 atomizes high-concentration cell plasma. The atomized gas-liquid mixture enters the nebulizer cylinder 81 through the atomizing plate 82 and flows along a preset trajectory under the guidance of the S-shaped continuous bend of the atomizing curve 83. Because tumor cell particles have large mass and inertia, they cannot make sharp turns with the airflow and directly collide with and adhere to the capture plate 811 on the inner wall of the nebulizer cylinder 81.
[0050] 5. Drainage and tissue recovery After centrifugation and atomization, the drive motor 51 rotates in the opposite direction, causing the support rod 52 to drive the displacement plate 53 to reset. The telescopic hose 62 extends, causing the inner ring 64 and outer ring 63 inside the telescopic hose 62 to separate. The liquid in the centrifuge cylinder 7 enters the drain pipe 61 through the telescopic hose 62 to begin drainage. The liquid flows into the drain chamber 65 through the drain pipe 61 and is finally discharged from the device through the water outlet pipe 66 at the bottom of the drain chamber 65.
[0051] Then, each component is disassembled and the nebulizer 81 is taken out. At this time, the solid tumor tissue sample adsorbed on the capture plate 811 can be directly used for subsequent pathological sections, immunohistochemistry and other examinations to complete the final tumor tissue recovery.
[0052] The foregoing has shown and described the basic principles, main features, and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited to the above embodiments. The embodiments and descriptions in the specification are merely illustrative of the principles of the invention. Various changes and modifications can be made to the invention without departing from its spirit and scope, and all such changes and modifications fall within the scope of the present invention as claimed. The scope of protection of this invention is defined by the appended claims and their equivalents.
Claims
1. A device for separating and recovering gynecological tumor tissue, characterized in that, include: Collection mechanism (1), which is attached to the wound; The separation and recovery mechanism (2), connected to the collection mechanism (1), is used to separate and recover the inhaled tumor tissue liquid mixture.
2. The gynecological tumor tissue separation and recovery device according to claim 1, characterized in that, The collection mechanism (1) includes: The collection cover (11) has a collection port (111) at the bottom and a suction cup (112) on the periphery of its lower surface. The collection chamber (12) is located inside the collection cover (11), and a ring of liquid inlets (121) is opened in the middle of it. The flushing pipe (13) is installed inside the collection hood (11).
3. The gynecological tumor tissue separation and recovery device according to claim 2, characterized in that, The separation and recovery mechanism (2) includes: The outer cylinder (3) is equipped with a negative pressure pump (31) on top and a filter plate (32) inside it. The inner cylinder (4) is rotatably installed inside the outer cylinder (3), and a power assembly (5) and a drainage assembly (6) are installed inside it. Centrifuge tube (7) is fixedly installed on inner tube (3), and its side wall is provided with multiple centrifuge holes (71); The atomizing component (8) is located at the bottom of the centrifuge tube (7) and is slidably connected to the inner tube (4).
4. The gynecological tumor tissue separation and recovery device according to claim 3, characterized in that, The power assembly (5) includes: The drive motor (51) is located on the bottom surface of the outer cylinder (3); The support rod (52) is connected to the output shaft of the drive motor (51) at one end and to the displacement plate (53) at the other end. The limiting rod (54) is fixedly connected to the support rod (52), and its two ends are slidably connected to the limiting groove (41) opened on the inner wall of the inner cylinder (4); The connecting rod (55) is located above the displacement plate (53) and is slidably connected to the support rod (52).
5. The gynecological tumor tissue separation and recovery device according to claim 4, characterized in that, The drainage assembly (6) includes: A drain pipe (61) is connected to the bottom of the displacement plate (53); The flexible hose (62) is connected to the drain pipe (61) at one end and passes through the inner cylinder (4) at the other end. The outer ring (63) is located on the inner bottom side of the telescopic hose (62); The inner ring (64) is located on the inner top side of the telescopic hose (62) and is configured in conjunction with the outer ring (63).
6. The gynecological tumor tissue separation and recovery device according to claim 5, characterized in that, The atomizing component (8) includes: Atomizing tube (81) is fitted on the outside of inner tube (4), and multiple capturing plates (811) are provided on its inner wall. Atomizing plate (82) is located above atomizing cylinder (81), and multiple atomizers (821) are installed on it. The atomizing bend (83) is located between the atomizing cylinder (81) and the inner cylinder (4).
Citation Information
Patent Citations
A device for separating and recovering gynecological tumor tissue
CN114768356B