A whitening and freckle-removing composition containing white tomato and its preparation method and application

Abstract

This invention discloses a whitening and freckle-removing composition containing white tomato and *Gynostemma pentaphyllum*, its preparation method, and its application, belonging to the field of food technology. The whitening and freckle-removing composition consists of white tomato powder and *Gynostemma pentaphyllum* powder in a weight ratio of 1-3:2-7. The preparation method includes the following steps: (1) white tomato is pulped, separated, concentrated, and dried to obtain white tomato powder; (2) *Gynostemma pentaphyllum* is soaked in acidic water, and the solid and liquid are separated. The resulting clear liquid is concentrated and dried to obtain *Gynostemma pentaphyllum* powder; (3) white tomato powder and *Gynostemma pentaphyllum* powder are mixed. This invention utilizes the combination of white tomato and *Gynostemma pentaphyllum*, and through improvements in the preparation process of *Gynostemma pentaphyllum*, the two produce a synergistic effect in inhibiting tyrosinase activity and melanin production.

Description

Technical Field

[0001] This invention belongs to the field of food technology, specifically relating to a whitening and freckle-removing composition containing white tomato and licorice root, its preparation method, and its application. Background Technology

[0002] White tomatoes are rich in colorless carotenoids (such as phytoene, hexahydrolycopene, and ζ-carotenoids), which have powerful antioxidant, anti-UV, and skin-whitening effects. Compared to regular tomatoes, the carotenoids in white tomato extract are colorless and will not deposit as pigment in the skin. Furthermore, they have stronger photostability and can effectively reduce UV-induced melanin production, thus being widely used in skincare, health supplements, and nutritional supplements.

[0003] Melanin production is driven by a series of complex biochemical processes, among which tyrosinase is the key rate-limiting enzyme. The activity of tyrosinase directly affects the production and deposition of melanin. Excessive melanin deposition not only causes aesthetic problems such as skin pigmentation, but is also associated with various skin conditions, such as melasma and age spots.

[0004] In existing technologies, there is still room for improvement in the inhibition of tyrosinase activity by white tomatoes, especially in the synergistic design of extraction processes and compound systems. Chinese Patent CN120154667A (publication date June 17, 2025) discloses a method for preparing freeze-dried white tomato exosome powder. This method uses an ultrasonic-cellulase synergistic disruption process to gently and efficiently disrupt cells, reducing damage to exosome structures and improving exosome release efficiency and activity; it can significantly inhibit melanin production in zebrafish embryos. Chinese Patent CN120130626A (publication date June 13, 2025) discloses a method for preparing water-soluble freeze-dried white tomato powder, introducing an enzymatic hydrolysis step to enzymatically hydrolyze the insoluble fiber and pectin contained in white tomatoes. The resulting freeze-dried white tomato powder has good antioxidant and whitening effects. Chinese patent CN120959402A (publication date November 18, 2025) discloses a white tomato fermentation extract, which is prepared by fermentation of fresh white tomatoes and golden top pine mushroom powder with yeast. The obtained white tomato fermentation extract can be used to remove oxygen free radicals and inhibit the formation of tyrosinase.

[0005] Penthorum chinense Pursh is a perennial herb belonging to the genus Penthorum in the family Saxifragaceae. It is a new resource food containing a large amount of flavonoids, organic acids, terpenes, and other active ingredients, and has antioxidant, anti-inflammatory, and liver-protective effects.

[0006] Currently, there are no reports on the use of white tomatoes and *Gynostemma pentaphyllum* to enhance the tyrosinase inhibitory activity of white tomatoes. Therefore, how to rationally combine the two to develop a composition with high tyrosinase inhibitory activity to meet the market demand for whitening and freckle-removing products is a technical problem that urgently needs to be solved. Summary of the Invention

[0007] To address the aforementioned technical problems, this invention provides a whitening and freckle-removing composition containing white tomato and licorice root, along with its preparation method and application.

[0008] Terminology Explanation: Unless otherwise defined, all technical terms used herein have the same meanings as commonly understood by one of ordinary skill in the art. Unless otherwise stated, all patents, patent inventions, and publications cited in this document are incorporated herein by reference in their entirety. If multiple definitions exist for terms, the definition provided in this chapter shall prevail.

[0009] It should be understood that the above brief description and the following detailed description are exemplary and for illustrative purposes only, and do not limit the subject matter of the invention in any way. In this invention, the singular is used in conjunction with the plural unless otherwise specifically stated. It should also be noted that, unless otherwise stated, the use of “or” or “or” means “and / or”. Furthermore, the use of the term “comprising” and other forms such as “including,” “containing,” and “contains” are not limiting.

[0010] Unless specifically defined herein, the use of all commercially available products herein employs standard techniques. For example, it may be carried out using the manufacturer's instructions for use with the kit, or in accordance with methods known in the art or the description of this invention. The techniques and methods described herein can generally be implemented according to conventional methods well known in the art, based on the descriptions in the various summary and more specific documents cited and discussed in this specification.

[0011] The terms “optional / arbitrary” or “optionally / arbitrarily” mean that the event or situation described below may or may not occur, including both the occurrence and non-occurrence of the event or situation.

[0012] The term "white tomato" (scientific name: *Solanum lycopersicum*) used in this article refers to an annual or perennial herbaceous plant belonging to the genus *Solanum* in the family Solanaceae. This plant grows to a height of 2.5-4 meters, with stems that easily lodge. Its branches and trunks have sticky glandular hairs and emit a strong odor. It has pinnate compound leaves and flowers in autumn and winter (the calyx and corolla are radiate). The fruit is oblate or nearly spherical, turning creamy white or pale yellow when ripe, weighing 150-200 grams per fruit. It is firm and stores well. This variety is indeterminate, contains almost no lycopene, but is rich in various vitamins and colorless carotenoids such as phytoene and hexahydrolycopene.

[0013] The term "Ganhuangcao" used in this article refers to the stems and leaves of Penthorum chinense Pursh, a plant belonging to the genus Penthorum in the family Saxifragaceae. The production process involves selecting, cleaning, moistening, cutting, and drying the stems and leaves of artificially cultivated Ganhuangcao.

[0014] The term "pulping" used in this article refers to the conventional operation of breaking down the tissue morphology of pretreated fruit and vegetable raw materials through physical forces such as mechanical grinding and crushing, so as to break down the raw materials and form a uniform slurry fluid. It is a basic process for achieving solid-liquid dispersion of fruit and vegetable raw materials and providing uniform materials for subsequent separation and concentration processes, including but not limited to mechanical stirring pulping, colloid milling, homogenizing pulping and other methods.

[0015] The term "concentration" as used in this article refers to a process that uses physical or chemical methods to remove solvents (such as water) from materials, thereby increasing the concentration and reducing the volume of the effective components in the materials. In this invention, the enrichment of effective components in the crushed white tomato materials and the extract of *Gynura divaricata* can be achieved using conventional concentration methods in the field, such as vacuum concentration, spray concentration, etc.

[0016] The term "solid-liquid separation" as used in this article refers to the process of separating the solid phase and the liquid phase in a solid-liquid mixture. In this invention, it is used to process the mixture after heating and extracting *Gynostemma pentaphyllum*. The separated clear liquid is used for subsequent concentration and drying. Conventional solid-liquid separation methods in the art, such as filtration (atmospheric pressure filtration, vacuum filtration), centrifugation, and pressing, can be used.

[0017] The term "drying" as used in this article refers to the conventional operation of removing moisture from liquid mixtures or solid components to obtain dried products, including but not limited to vacuum freeze drying, low-temperature drying, spray drying, and hot air drying.

[0018] In a first aspect, the present invention provides a whitening and freckle-removing composition containing white tomato and ginseng, which is composed of white tomato powder and ginseng powder.

[0019] The white tomato of this invention is rich in active ingredients such as phytoene, hexahydrolycopene, and ζ-carotene, all colorless carotenoids. It is a natural whitening ingredient that can directly inhibit tyrosinase activity in skin pigment metabolism, blocking melanin synthesis at its source. It can also resist UV damage and reduce photo-induced pigmentation. *Gynostemma pentaphyllum* can effectively scavenge free radicals and regulate the balance between the oxidative and antioxidant systems. Furthermore, studies have found that ethanol-extracted *Gynostemma pentaphyllum* substances not only have antioxidant properties but can also induce autophagy to block photoaging reactions and inhibit melanin production.

[0020] In some embodiments, the weight ratio of the white tomato powder to the *Gynostemma pentaphyllum* powder is 1-3:2-7; for example, 1.0:2.0, 1.0:2.5, 1.0:3.0, 1.0:3.5, 1.0:4.0, 1.0:4.5, 1.0:5.0, 1.0:5.5, 1.0:6.0, 1.0:6.5, 1.0:7.0, 1.2:2.0, 1.2:2.5, 1.2:3.0, 1.2:3.5, 1.2:4.0, 1.2:4.5, 1.2:5.0, 1.2:5.5, 1.2:6.0, 1.2:6.5, 1.2:7.0, 1.4:2.0, 1.4:2.5, 1.4:3.0, 1.4:3.5, 1.4:4.0 1.4:4.5, 1.4:5.0, 1.4:5.5, 1.4:6.0, 1.4:6.5, 1.4:7.0, 1.6:2.0, 1.6:2.5, 1.6:3.0, 1.6:3.5, 1.6:4.0, 1.6:4.5, 1.6:5.0, 1.6:5.5, 1.6:6.0, 1.6: 6.5, 1.6:7.0, 1.8:2.0, 1.8:2.5, 1.8:3.0, 1.8:3.5, 1.8:4.0, 1.8:4.5, 1.8:5.0, 1.8:5.5, 1.8:6.0, 1.8:6.5, 1.8:7.0, 2.0:2.0, 2.0:2.5, 2.0:3.0, 2 .0:3.5, 2.0:4.0, 2.0:4.5, 2.0:5.0, 2.0:5.5, 2.0:6.0, 2.0:6.5, 2.0:7.0, 2.2:2.0, 2.2:2.5, 2.2:3.0, 2.2:3.5, 2.2:4.0, 2.2:4.5, 2.2:5.0, 2.2:5. 5, 2.2:6.0, 2.2:6.5, 2.2:7.0, 2.4:2.0, 2.4:2.5, 2.4:3.0, 2.4:3.5, 2.4:4.0, 2.4:4.5, 2.4:5.0, 2.4:5.5, 2.4:6.0, 2.4:6.5, 2.4:7.0, 2.6:2.0, 2.6 2.5, 2.6:3.0, 2.6:3.5, 2.6:4.0, 2.6:4.5, 2.6:5.0, 2.6:5.5, 2.6:6.0, 2.6:6.5, 2.6:7.0, 2.8:2.0, 2.8:2.5, 2.8:3.0, 2.8:3.5, 2.8:4.0, 2.8:4.5 2.8:5.0, 2.8:5.5, 2.8:6.0, 2.8:6.5, 2.8:7.0, 3.0:2.0, 3.0:2.5, 3.0:3.0, 3.0:3.5, 3.0:4.0, 3.0:4.5, 3.0:5.0, 3.0:5.5, 3.0:6.0, 3.0:6.5, 3.0:7.The range of 0 or its derivatives.

[0021] In some embodiments, the weight ratio of the white tomato to *Gynura divaricata* is preferably 1.4-2.6:3-6.

[0022] In some embodiments, the weight ratio of the white tomato to *Gynura divaricata* is further preferably 1.8-2.2:4-5.5.

[0023] Secondly, the present invention provides a method for preparing the above-mentioned composition, comprising the following steps: (1) White tomatoes are pulped, separated, concentrated and dried to obtain white tomato powder; (2) Soaking the herb in acidic water and separating the solid and liquid, the resulting clear liquid is concentrated and dried to obtain herb powder; (3) Mix white tomato powder and ginseng powder together.

[0024] In some implementations, the *Ganhuangcao* mentioned in step (2) is at least one of the stems and leaves of *Ganhuangcao*.

[0025] In some embodiments, the acidic water in step (2) is an acidic aqueous solution with a mass fraction of 0.1%-0.3%; for example, the mass fraction of the acidic aqueous solution may be 0.1%, 0.2%, 0.3%, or a range derived therefrom.

[0026] In some embodiments, the acid is at least one selected from citric acid, acetic acid, malic acid, tartaric acid, and sodium malate.

[0027] In some implementations, the soaking in step (2) is performed at a temperature of 85-100°C for a time of 0.5-3 hours. For example, the temperature can be selected from 85°C, 86°C, 87°C, 88°C, 89°C, 90°C, 91°C, 92°C, 93°C, 94°C, 95°C, 96°C, 97°C, 98°C, 99°C, 100°C, or a range derived therefrom; the time can be selected from 0.5 hours, 0.6 hours, 0.7 hours, 0.8 hours, 0.9 hours, 1.0 hours, 1.1 hours, 1.2 hours, 1.3 hours, 1.4 hours, 1.5 hours, 1.6 hours, 1.7 hours, 1.8 hours, 1.9 hours, 2.0 hours, 2.1 hours, 2.2 hours, 2.3 hours, 2.4 hours, 2.5 hours, 2.6 hours, 2.7 hours, 2.8 hours, 2.9 hours, 3.0 hours, or a range derived therefrom.

[0028] Thirdly, the present invention provides the application of the above-described composition or the composition prepared by the above-described preparation method in the preparation of whitening and freckle-removing products.

[0029] The composition of this invention uses white tomato and Gynostemma pentaphyllum as its core active ingredients, which can effectively inhibit tyrosinase activity, scavenge free radicals, regulate the balance of the oxidation and antioxidant system, accelerate the metabolism and excretion of melanin, and at the same time soothe skin inflammation and optimize the internal environment of the skin, achieving the dual effect of reducing melanin production from the root and fading existing pigmentation from the surface.

[0030] In some implementations, the product is food, health products, medicine, or cosmetics.

[0031] The amount of the composition described in this invention can be adjusted according to the dosage form and usage requirements of the product. Those skilled in the art can combine the composition with corresponding excipients and carriers according to the industry preparation standards for food, health products, pharmaceuticals or cosmetics to prepare products in different forms, which are suitable for people with corresponding skin problems.

[0032] Fourthly, the present invention provides a whitening and freckle-removing product, comprising the above-mentioned composition or the composition prepared by the above-mentioned preparation method, and excipients acceptable in food or health products.

[0033] The present invention has at least the following beneficial effects: 1. This invention improves the preparation process by using acidic water extraction, which promotes the dissolution of water-soluble components in *Gynostemma pentaphyllum*, thus ensuring efficient retention of active ingredients. Compared with conventional *Gynostemma pentaphyllum* extraction processes, the *Gynostemma pentaphyllum* powder prepared by this invention, when combined with white tomato powder, has a better effect on inhibiting tyrosinase activity and melanin production.

[0034] 2. Experiments have shown that the present invention utilizes a combination of white tomato powder and *Gynostemma pentaphyllum* powder, and through improvements to the preparation process of *Gynostemma pentaphyllum*, the two produce a synergistic effect in inhibiting tyrosinase activity and melanin production.

[0035] 3. The product prepared by this invention, which combines white tomato powder and ginseng powder, can effectively inhibit tyrosinase activity, scavenge free radicals, regulate the balance of the oxidation and antioxidant system, accelerate the metabolism and excretion of melanin, and at the same time soothe skin inflammation and optimize the internal environment of the skin, thus achieving the dual effect of reducing melanin production from the root and fading existing pigmentation from the surface. Detailed Implementation

[0036] The following non-limiting embodiments are intended to enable those skilled in the art to gain a more comprehensive understanding of the present invention, but do not limit the invention in any way. The following content is merely an exemplary description of the scope of protection claimed by the present invention, and those skilled in the art can make various changes and modifications to the present invention based on the disclosed content, and such changes should also fall within the scope of protection claimed by the present invention.

[0037] The present invention will be further described below by way of specific embodiments. Unless otherwise specified, all instruments, devices, equipment, reagents, products, etc., used in the embodiments of the present invention are obtained through conventional commercial means.

[0038] All numerical values ​​or expressions relating to component amounts, process conditions, etc., used in this invention should be understood to be modified by "about" in all cases. When referring to a quantity or range of values, the quantity or range is an approximation within experimental variability (or within statistical experimental error). In this invention, the term "about" should have the meaning of being within 10%, preferably within 5%, of a specified value or range. The drying described in this embodiment and comparative example is to make the moisture content of the dried material, such as white tomato powder or *Gynostemma pentaphyllum* powder, approximately 4 wt%.

[0039] Unless otherwise specified, the temperature mentioned in this invention is room temperature (20-25℃), the solvent is water, and the percentage (%) is a mass percentage.

[0040] Example 1 A whitening and freckle-removing composition containing white tomato and ginseng, which is made by mixing white tomato powder and ginseng powder in a weight ratio of 1:2; The preparation method of the white tomato powder is as follows: remove the stems from the white tomatoes, wash them, cut them into pieces and pulp them, filter them through a membrane (200nm), and dry the filtrate under vacuum at low temperature (temperature 40℃, vacuum degree -0.09MPa). The preparation method of the *Ganhuangcao* powder is as follows: the leaves of *Ganhuangcao* are soaked in a 0.3% citric acid aqueous solution at 85℃ for 1 hour, filtered, and the resulting clear liquid is concentrated and spray-dried at an inlet temperature of 90℃ and an outlet temperature of 45℃ to obtain *Ganhuangcao* powder.

[0041] Example 2 A whitening and freckle-removing composition containing white tomato and ginseng, which is made by mixing white tomato powder and ginseng powder in a weight ratio of 3:7; The preparation method of the white tomato powder is as follows: remove the stems from the white tomatoes, wash them, cut them into pieces and pulp them, filter them through a membrane (200nm), and dry the filtrate under vacuum at low temperature (temperature 40℃, vacuum degree -0.09MPa). The preparation method of the *Ganhuangcao* powder is as follows: the leaves of *Ganhuangcao* are soaked in a 0.1% citric acid aqueous solution at 100℃ for 3 hours, filtered, and the resulting clear liquid is concentrated and spray-dried at an inlet temperature of 90℃ and an outlet temperature of 45℃.

[0042] Example 3 A whitening and freckle-removing composition containing white tomato and ginseng, which is made by mixing white tomato powder and ginseng powder in a weight ratio of 2:5; The preparation method of the white tomato powder is as follows: remove the stems from the white tomatoes, wash them, cut them into pieces and pulp them, filter them through a membrane (200nm), and dry the filtrate under vacuum at low temperature (temperature 40℃, vacuum degree -0.09MPa). The preparation method of the *Ganhuangcao* powder is as follows: the leaves of *Ganhuangcao* are soaked in a 0.2% citric acid aqueous solution at 90℃ for 2 hours, filtered, and the resulting clear liquid is concentrated and spray-dried at an inlet temperature of 90℃ and an outlet temperature of 45℃.

[0043] Comparative Example 1 The difference between this comparative example and Example 3 is that it does not contain *Gynostemma pentaphyllum* powder.

[0044] Specifically, a whitening and freckle-removing composition containing white tomato and licorice is white tomato powder; The preparation method of the white tomato powder is as follows: remove the stems from the white tomatoes, wash them, cut them into pieces and pulp them, filter them through a membrane (200nm), and dry the filtrate under vacuum at low temperature (temperature 40℃, vacuum degree -0.09MPa).

[0045] Comparative Example 2 The difference between this comparative example and Example 3 is that it does not contain white tomato powder.

[0046] Specifically, a whitening and freckle-removing composition containing white tomato and ginseng is ginseng powder; The preparation method of the *Ganhuangcao* powder is as follows: soak the leaves of *Ganhuangcao* in water at 90℃ for 2 hours, filter, concentrate the resulting clear liquid and spray dry it at an air inlet temperature of 90℃ and an air outlet temperature of 45℃.

[0047] Comparative Example 3 The difference between this comparative example and Example 3 is that the preparation method of *Ganhuangcao* is different.

[0048] Specifically: a whitening and freckle-removing composition containing white tomato and ginseng, which is made by mixing white tomato powder and ginseng powder in a weight ratio of 2:5; The preparation method of the white tomato powder is as follows: remove the stems from the white tomatoes, wash them, cut them into pieces and pulp them, filter them through a membrane (200nm), and dry the filtrate under vacuum at low temperature (temperature 40℃, vacuum degree -0.09MPa). The preparation method of the *Ganhuangcao* powder is as follows: soak the leaves of *Ganhuangcao* in water at 90℃ for 2 hours, filter, concentrate the resulting clear liquid and spray dry it at an air inlet temperature of 90℃ and an air outlet temperature of 45℃.

[0049] Detection Example 1 Tyrosinase inhibitory activity test At 25°C, 2.5 mmol / L L-DOPA solution and sample solution were added sequentially to a 96-well plate, and the volume was adjusted to 0.1 mol / L, pH 6.8 phosphate-buffered saline (PBS), and incubated for 10 min. Then, 1000 U / mL tyrosinase solution was added, and incubation continued for another 10 min. The absorbance of the reaction solution was measured at 475 nm using a multi-mode microplate reader. Three replicates were prepared for each group.

[0050] Formula for calculating tyrosinase inhibition rate: Inhibition rate (%) = (A blank control group - A sample group) / A blank control group × 100%, In the formula, sample A is the absorbance value after sample addition, control A is the blank absorbance value without sample addition, and 0.03 mg / mL kojic acid is used as a positive control.

[0051] The results are shown in Table 1.

[0052] Table 1

[0053] The results showed that the compositions prepared in Examples 1-3 of the present invention had good inhibitory activity against tyrosinase, with an inhibition rate of 80.8%-83.1%.

[0054] Meanwhile, according to Comparative Examples 1 and 2, the inhibitory activity of single white tomato powder and *Gynostemma pentaphyllum* powder on tyrosinase was poor, with an inhibition rate of only 29.3%-44.2%. This indicates that the combination of tomato powder and *Gynostemma pentaphyllum* powder has a synergistic effect in inhibiting tyrosinase activity.

[0055] Comparison Example 3 shows that the tyrosinase inhibition rate of the compound of *Gynostemma pentaphyllum* powder obtained by conventional water soaking and tomato powder is only 43.0%, indicating that the compound of *Gynostemma pentaphyllum* powder prepared by conventional extraction process and tomato powder does not have the above-mentioned synergistic effect.

[0056] Detection Example 2 The culture medium was DMEM complete medium (containing 10% FBS by volume).

[0057] B16-F10 cells were used at a rate of 5 × 10⁻⁶ 4 Inoculate at a density of cells / well in 96-well plates and incubate overnight in a 37°C, 5% CO2 incubator. Discard the supernatant after incubation.

[0058] The cells were divided into a sample group and a cell control group, with three replicates in each group.

[0059] Sample group: Add 20 μL of culture medium containing the sample (1.00 mg / mL); Cell control group: Add 20 μL of culture medium; After culturing for another 48 hours, the cells were collected into sterile EP tubes and centrifuged at 2500 rpm for 5 min. The supernatant was discarded, and the cells were washed three times with PBS buffer. 150 μL of 1 mmol / L NaOH (containing 10 wt% DMSO) was added to each EP tube. The mixture was then pipetted and transferred to a 96-well plate. The absorbance at 475 nm was measured using a microplate reader. The plate was zeroed with a blank (containing only culture medium and no cells or samples). The ratio of absorbance between the sample group and the cell control group was the melanin content.

[0060] The results are shown in Table 2.

[0061] Table 2

[0062] The results showed that, compared with the cell control group, the absorbance values ​​of the sample groups in Examples 1-3 of the present invention were significantly different (P < 0.05), and the melanin content was reduced in all groups. This indicates that the compositions prepared in Examples 1-3 of the present invention can inhibit melanin production.

[0063] Meanwhile, according to Comparative Examples 1, 2, and 3, the combination of single white tomato powder, *Gynostemma pentaphyllum* powder, and *Gynostemma pentaphyllum* powder obtained by conventional water soaking with tomato powder showed poor ability to inhibit melanin production, with no significant difference in absorbance values ​​compared to the cell control group (P > 0.05). This indicates that the combination of tomato powder and *Gynostemma pentaphyllum* powder obtained by the specific preparation process of this invention has a synergistic effect in inhibiting melanin production.

[0064] Finally, it should be noted that the above content is only used to illustrate the technical solution of the present invention, and is not intended to limit the scope of protection of the present invention. Simple modifications or equivalent substitutions made by those skilled in the art to the technical solution of the present invention do not depart from the essence and scope of the technical solution of the present invention.

Claims

1. A whitening and freckle-removing composition containing white tomato and licorice root, characterized in that, It consists of white tomato powder and ginseng powder in a weight ratio of 1-3:2-7; The powder of Ganhuangcao is made by soaking Ganhuangcao in acidic water, separating the solid and liquid, and concentrating and drying the resulting clear liquid.

2. The whitening and freckle-removing composition according to claim 1, characterized in that, The weight ratio of the white tomato powder to the *Gynostemma pentaphyllum* powder is 1.4-2.6:3-6.

3. The whitening and freckle-removing composition according to claim 1, characterized in that, The weight ratio of the white tomato powder to the *Gynostemma pentaphyllum* powder is 1.8-2.2:4-5.

5.

4. The whitening and freckle-removing composition according to claim 1, characterized in that, The weight ratio of the white tomato powder to the *Gynostemma pentaphyllum* powder is 2:

5.

5. A method for preparing the whitening and freckle-removing composition according to any one of claims 1-4, characterized in that, Includes the following steps: (1) White tomatoes are pulped, separated, concentrated and dried to obtain white tomato powder; (2) Soaking the herb in acidic water and separating the solid and liquid, the resulting clear liquid is concentrated and dried to obtain herb powder; (3) Mix white tomato powder and ginseng powder together.

6. The preparation method according to claim 5, characterized in that, The acidic water mentioned in step (2) is an acidic aqueous solution with a mass fraction of 0.1%-0.3%.

7. The preparation method according to claim 6, characterized in that, The acid mentioned in step (2) is at least one of citric acid, acetic acid, malic acid, tartaric acid and sodium malate.

8. The preparation method according to claim 5, characterized in that, The soaking in step (2) is carried out at a temperature of 85-100℃ for a time of 0.5-3h.

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