A lung-clearing and cough-stopping herbal dispersant, and a preparation method and application thereof

Abstract

This invention provides a lung-clearing and cough-relieving herbal remedy, which, based on the total weight percentage of the dried plant materials used to prepare the remedy, comprises the following main components: 8-10% *Corydalis yanhusuo*, 8-10% *Gnaphalium affine*, 8-10% *Citrus reticulata* peel, 7-10% *Houttuynia cordata*, 7-10% *Trichosanthes kirilowii*, 7-9% *Houttuynia cordata*, 7-9% *Polygonum cuspidatum*, 7-9% *Sarcandra glabra*, 6-8% *Adenophora stricta*, 6-8% *Fritillaria cirrhosa*, and 5-7% *Perilla frutescens*. This invention utilizes 11 medicinal herbs... Among the list of items that are both food and medicine, this product is precisely formulated according to the theories of "four qi and five flavors" and meridian tropism. It is rich in natural active ingredients such as fritillary alkaloids, fritillary alkaloid A and B, hesperidin, and houttuynia cordata. It has both dietary and medicinal properties, and is extremely safe. In the first stage, it targets and detoxifies, clears blood vessels and eliminates the root cause of the disease. In the second stage, it reduces inflammation and kills bacteria, repairs damaged alveoli and promotes regeneration. This progressive treatment can not only dissipate pulmonary ground-glass nodules and solid nodules, but also inhibit density transformation and prevent recurrence.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine preparation technology, and in particular to a herbal remedy for clearing the lungs and relieving cough, its preparation method, and its application. Background Technology

[0002] The lungs are an extremely important respiratory organ in the human body. In recent years, epidemiological data have shown that the detection rate of pulmonary nodules in my country has reached as high as 20%-40%, meaning that about one in five people will be diagnosed with pulmonary nodules.

[0003] Meanwhile, there are 358 million asthma patients and about 328 million COPD patients worldwide, exhibiting epidemiological characteristics of high morbidity and high mortality.

[0004] A new generation of technologies focusing on the prevention and treatment of lung diseases is emerging, but existing traditional Chinese medicine formulas for clearing the lungs, dispersing nodules, and relieving coughs have significant shortcomings: I. The Chinese medicinal herbs used in the existing products are mostly not "food and medicine homology" plants, and contain strong or toxic components. They can only temporarily relieve symptoms and are not suitable for patients to take for a long time to achieve root-cause conditioning. Second, existing technologies are insufficient to meet the multi-dimensional maintenance needs of lung diseases, and cannot effectively repair damaged lung tissue and promote alveolar regeneration, thus only treating the symptoms and not the root cause. III. Traditional Chinese medicine compound preparations rely heavily on the addition of chemical preservatives such as sodium benzoate to prevent fermentation and spoilage during preparation and storage. Long-term intake poses potential health risks. Therefore, a lung-clearing and cough-relieving herbal compound preparation, along with its preparation method and application, is proposed. Summary of the Invention

[0005] In view of this, embodiments of the present invention provide a herbal remedy for clearing the lungs and relieving cough, along with its preparation method and application, to solve or alleviate the technical problems existing in the prior art, and at least provide a beneficial alternative.

[0006] The technical solution of this invention is implemented as follows: A lung-clearing and cough-relieving herbal remedy, based on the total weight percentage of the dried plant raw materials used to prepare the herbal remedy, comprises the following main components: Cat's Claw Grass 8-10%, Gnaphalium affine 8-10%, Citrus reticulata peel 8-10%, Toad Grass 7-10%, Trichosanthes kirilowii 7-10%, Houttuynia cordata 7-9%, Polygonum aviculare 7-9%, Sargassum fusiforme 7-9%, Adenophora stricta 6-8%, Fritillaria cirrhosa 6-8%, and Perilla frutescens 5-7%; The auxiliary materials include 1-2% steviol glycosides and 1-2% pineapple flavoring, based on a percentage of the total weight of the dried plant raw materials. In addition, purified water is added as an extraction solvent and final formulation carrier, and the mixture is extracted and concentrated to produce an oral liquid formulation.

[0007] In some embodiments, the preferred proportions of the main ingredients, based on the total weight percentage of the dried plant raw materials, are as follows: Cat's Claw Grass 9%, Gnaphalium affine 9%, Citrus reticulata peel 9%, Toad Grass 8.5%, Trichosanthes kirilowii 8.5%, Houttuynia cordata 8%, Polygonum multiflorum 8%, Coral Root 8%, Adenophora stricta 7%, Fritillaria cirrhosa 7%, and Perilla frutescens 6%; The amount of stevioside added is 1.5% of the total weight of the dried raw materials, and the amount of pineapple flavor added is 1.5% of the total weight of the dried raw materials.

[0008] In some embodiments, the finished product of the herbal granulation agent is a clear, brownish-brown liquid with a sweet and slightly bitter taste, and no chemical preservatives are added.

[0009] A method for preparing a lung-clearing and cough-relieving herbal remedy, as described above, includes the following detailed steps: S1. Take the following dried plant products in the prescribed amounts: cat's claw grass, cudweed, tangerine peel, toad grass, trichosanthes, houttuynia cordata, angelica sinensis, coral grass, glehnia littoralis, fritillaria cirrhosa, and perilla seeds. Grind them into coarse powder. Use percolation method with 57% ethanol as solvent. After soaking for 24 hours, slowly percolate at a rate of 1 ml per minute and collect about 6000 ml of percolate. S2. The collected filtrate is depressurized to recover ethanol and concentrated to a volume of about 1400 ml. The concentrate is then removed and 800 ml of purified water is added. The mixture is boiled for 30 minutes and allowed to stand for 48 hours to allow impurities to precipitate. The filtrate and residue are filtered. The residue is washed with a small amount of purified water to obtain the washing liquid. The washing liquid is then added to the combined filtrate. S3. Concentrate the combined filtrate under reduced pressure to about 1000 ml, add the formula amount of steviol glycosides and pineapple flavoring, stir well, let stand for 24 hours, filter, add purified water to adjust to the final total volume and stir well to obtain the prepared medicine solution. S4. Heat the prepared medicine solution to a slight boiling point, quickly fill it into a clean, sterilized resin thermos bottle preheated to 80°C, immediately seal the bottle opening, and after cooling, a semi-vacuum state will be formed in the upper space of the bottle opening, thus obtaining the medicine.

[0010] In some embodiments, the semi-vacuum physical environment formed by hot filling and cooling in S4 replaces chemical preservatives, so that the finished product can be stored under sealed and cool conditions for one year without fermentation, mold growth, or rancidity.

[0011] The application of a herbal formula for clearing the lungs and relieving cough, as described above, in the preparation of drugs that have the functions of clearing the lungs and relieving cough, relieving cough and expectoration, and repairing damaged alveolar function.

[0012] In some embodiments, the drug is used to treat symptoms of coughing up purulent and hemoptysis caused by pulmonary ground-glass nodules, solid nodules, multiple nodules, infectious nodules, COPD, pulmonary heart disease, chronic bronchitis, and lung abscess.

[0013] The embodiments of the present invention have the following advantages due to the adoption of the above technical solutions: I. This invention utilizes 11 Chinese medicinal herbs, all of which are listed as both food and medicine. Following the principles of "four natures and five flavors" and meridian tropism, the herbs are precisely formulated and rich in natural active ingredients such as fritillary alkaloids, fritillary alkaloid A and B, hesperidin, and houttuynia cordata. It possesses both dietary and medicinal properties, ensuring extremely high safety. The first stage targets and detoxifies, clears blood vessels to eliminate the root cause of the disease, while the second stage promotes anti-inflammatory and antibacterial effects and repairs damaged alveoli for regeneration. This progressive treatment not only dissipates pulmonary ground-glass nodules and solid nodules but also inhibits density transformation and prevents recurrence.

[0014] Second, this invention completely abandons the traditional sodium benzoate preservation process and adopts a micro-boiling hot filling method. It utilizes the semi-vacuum state formed by filling and sealing the bottle at 80°C and then cooling it to inhibit the growth of microorganisms and ensure that the product has a shelf life of up to one year.

[0015] Third, this invention effectively masks the fishy and bitter odor of houttuynia cordata, toad grass, etc., through the synergistic effect of a specific ratio of steviol glycosides and pineapple flavoring, and significantly improves patients' medication compliance.

[0016] The above overview is for illustrative purposes only and is not intended to be limiting in any way. Detailed Implementation

[0017] In the following description, only certain exemplary embodiments are briefly described. As those skilled in the art will recognize, the described embodiments can be modified in various ways without departing from the spirit or scope of the invention.

[0018] It is important to note that terms such as "first," "second," "symmetric," "array," "set in," and "set with" are used only to distinguish between descriptive and positional descriptions and should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features indicated. Therefore, features specified with terms such as "first" or "symmetric" may explicitly or implicitly include one or more of that feature; similarly, when the quantity of certain features is not limited by words such as "two" or "three," it should be noted that such features also explicitly or implicitly include one or more features.

[0019] In this invention, unless otherwise explicitly specified and limited, terms such as “installation,” “connection,” and “fixation” should be interpreted broadly; for example, they can be fixed connections, detachable connections, or integral moldings; they can be mechanical connections, direct connections, welding, or indirect connections through an intermediate medium; they can be internal connections between two components or the interaction between two components.

[0020] This invention provides a herbal remedy for clearing the lungs and relieving cough, which consists of the following main components based on the total weight percentage of the dried plant materials used to prepare the remedy: Cat's Claw Grass 8-10%, Gnaphalium affine 8-10%, Citrus reticulata peel 8-10%, Toad Grass 7-10%, Trichosanthes kirilowii 7-10%, Houttuynia cordata 7-9%, Polygonum aviculare 7-9%, Sargassum fusiforme 7-9%, Adenophora stricta 6-8%, Fritillaria cirrhosa 6-8%, and Perilla frutescens 5-7%; The auxiliary materials, based on the percentage of the total weight of the dried plant raw materials, include 1-2% steviol glycosides and 1-2% pineapple flavoring; In addition, purified water is added as an extraction solvent and final formulation carrier, and the mixture is extracted and concentrated to produce an oral liquid formulation.

[0021] In this embodiment, specifically, the preferred ratio of the main ingredients, based on the total weight percentage of the dried plant raw materials, is as follows: Cat's Claw Grass 9%, Gnaphalium affine 9%, Citrus reticulata peel 9%, Toad Grass 8.5%, Trichosanthes kirilowii 8.5%, Houttuynia cordata 8%, Polygonum multiflorum 8%, Coral Root 8%, Adenophora stricta 7%, Fritillaria cirrhosa 7%, and Perilla frutescens 6%; The amount of steviol glycosides added is 1.5% of the total weight of the dried raw materials, and the amount of pineapple flavor added is 1.5% of the total weight of the dried raw materials.

[0022] In this embodiment, specifically, the finished product of Baicao Sanjie is a clear, brownish-brown liquid with a sweet and slightly bitter taste, and no chemical preservatives are added.

[0023] A method for preparing a lung-clearing and cough-relieving herbal remedy, as described above, includes the following detailed steps: S1. Take the following dried plant products in the prescribed amounts: cat's claw grass, cudweed, tangerine peel, toad grass, trichosanthes, houttuynia cordata, angelica sinensis, coral grass, glehnia littoralis, fritillaria cirrhosa, and perilla seeds. Grind them into coarse powder. Use percolation method with 57% ethanol as solvent. After soaking for 24 hours, slowly percolate at a rate of 1 ml per minute and collect about 6000 ml of percolate. S2. The collected filtrate is depressurized to recover ethanol and concentrated to a volume of about 1400 ml. The concentrate is then removed and 800 ml of purified water is added. The mixture is boiled for 30 minutes and allowed to stand for 48 hours to allow impurities to precipitate. The filtrate and residue are filtered. The residue is washed with a small amount of purified water to obtain the washing liquid. The washing liquid is then added to the combined filtrate. S3. Concentrate the combined filtrate under reduced pressure to about 1000 ml, add the formula amount of steviol glycosides and pineapple flavoring, stir well, let stand for 24 hours, filter, add purified water to adjust to the final total volume and stir well to obtain the prepared medicine solution. S4. Heat the prepared medicine solution to a slight boiling point, quickly fill it into a clean, sterilized resin thermos bottle preheated to 80°C, immediately seal the bottle opening, and after cooling, a semi-vacuum state will be formed in the upper space of the bottle opening, thus obtaining the medicine.

[0024] In this embodiment, specifically, in S4, the semi-vacuum physical environment formed by hot filling and cooling is used to replace chemical preservatives, so that the finished product can be stored under sealed and cool conditions for one year without fermentation, mold growth, or rancidity.

[0025] The application of a herbal formula for clearing the lungs and relieving cough, as described above, in the preparation of drugs that have the functions of clearing the lungs and relieving cough, relieving cough and expectoration, and repairing damaged alveolar function.

[0026] In this embodiment, the drug is specifically used to treat symptoms of coughing up purulent and hemoptysis caused by pulmonary ground-glass nodules, solid nodules, multiple nodules, infectious nodules, COPD, pulmonary heart disease, chronic bronchitis, and lung abscess.

[0027] In this embodiment, specifically, a herbal remedy for clearing the lungs and relieving cough, calculated per 100g of dried raw material: Cat's Claw Grass 9g, Gnaphalium affine 9g, Citrus reticulata peel 9g, Toad Grass 8.5g, Trichosanthes kirilowii 8.5g, Houttuynia cordata 8g, Polygonum multiflorum 8g, Coralwort 8g, Adenophora stricta 7g, Fritillaria cirrhosa 7g, Perilla frutescens 6g.

[0028] Ingredients: 1.5g steviol glycosides, 1.5g pineapple flavoring, and appropriate amount of purified water.

[0029] In this embodiment, specifically, I. Anti-inflammatory effect experiment (xylene-induced mouse ear swelling model) Experimental methods: Fifty mice were randomly divided into 5 groups (blank group, model group, positive drug dexamethasone group, low-dose group of the present invention, and high-dose group of the present invention). The mice were administered the drug by gavage for 7 consecutive days. After the last administration, xylene was applied to both sides of the right ear of the mice to induce inflammation, and the left ear was used as a control. One hour later, both ears were cut off, and ear pieces were removed with a punch and weighed. The degree of swelling (right ear weight - left ear weight) and the swelling inhibition rate were calculated. Detailed data: Swelling level in the control group: 0mg Swelling degree in the model group: 18.45 ± 2.31 mg Swelling degree in the positive drug group: 6.12±1.05mg (inhibition rate 66.8%) The swelling level in the low-dose group of this invention was 10.34 ± 1.87 mg (inhibition rate 43.9%). The swelling level in the high-dose group of this invention was 7.25 ± 1.22 mg (inhibition rate 60.7%). The high-dose group of this invention has a highly significant inhibitory effect on acute inflammation induced by xylene (P<0.01 compared with the model group), with an inhibition rate as high as 60.7%, which is close to the positive control level of Western medicine, proving that it has definite effects of clearing heat and detoxifying and anti-inflammatory.

[0030] II. Experiment on antitussive and expectorant effects Experimental methods: The cough suppression test used concentrated ammonia water spray to induce coughing, and the cough latency and the number of coughs within 2 minutes were recorded in mice; the expectoration test used the phenol red excretion method in mice to determine the amount of phenol red excreted from the trachea (μg / mL). Detailed data: The high-dose group of this invention can prolong the cough latency period to near normal levels, significantly reduce the number of coughs, and significantly increase the amount of phenol red secreted in the respiratory tract, confirming that the combination of tangerine peel, fritillaria cirrhosa, perilla seed and other ingredients in the formula produces a very strong synergistic effect of relieving cough and expectoration.

[0031] III. Experiment on the mechanism of nodule dissipation and alveolar repair (bleomycin-induced rat pulmonary fibrosis / nodule model) Experimental methods: A pulmonary nodule and fibrosis model was established by intratracheal instillation of bleomycin in rats. After 28 days of gavage administration, lung tissue was collected for HE staining and pathological scoring (0-4 points, the higher the score, the more severe the nodules and fibrosis). Immunohistochemistry was used to detect the positive expression rates of α-SMA (smooth muscle actin, reflecting the process of alveolar epithelial damage repair and fibrosis) and TGF-β1 (transforming growth factor, the core factor promoting fibrosis) in lung tissue. Detailed data: The model group rats developed a large number of solid nodules in their lungs, and TGF-β1 and α-SMA were highly expressed. The high-dose group of this invention not only reduced the pathological score to near normal (1.1 points, indicating that the nodular lesions have basically disappeared), but also suppressed the expression levels of TGF-β1 and α-SMA to about 10% at the molecular level. This scientifically confirms the mechanism of action of the invention, which is to "eliminate inflammation and bacteria in the second stage, eliminate lung inflammation, and repair and regenerate damaged alveoli," namely, to reverse nodular lesions from the root by downregulating the pro-fibrosis pathway.

[0032] IV. Long-term stability study with zero preservatives Experimental methods: The finished product prepared in Example 1 (without any preservatives) was placed in a cool place (temperature 20±2℃), and samples were taken at 0, 3, 6, 9 and 12 months to test the microbial limits (total number of aerobic bacteria, total number of molds and yeasts) and sensory characteristics. Detailed data: Accelerated and long-term stability studies over a period of 12 months show that even without the addition of preservatives such as sodium benzoate, the product's bacterial count is far below the safety limits of the National Pharmacopoeia thanks to the unique hot-filling semi-vacuum process of this invention, and there is no rancidity or off-odor. This completely solves the technical pain point of traditional Chinese medicine compound preparations relying on preservatives.

[0033] In this embodiment, specifically, the low-dose group of the present invention is 2.0g crude drug / kg body weight; In this invention, the dosage group is 4.0 g of crude drug per kg of body weight. The high-dose group of this invention: 6.0g crude drug / kg body weight.

[0034] In this embodiment, a typical clinical application case is specifically provided. Case 1: Multiple pulmonary ground-glass nodules with intractable dry cough Ms. Wang, 52 years old, was found to have multiple ground-glass nodules in both lungs (maximum diameter 8mm) during a physical examination. She had been suffering from recurrent dry cough for more than three months, which worsened at night. After ruling out malignant signs, she was given this preparation orally (50ml each time, three times a day, after meals).

[0035] Therapeutic effect observation: After the first course of treatment (7 days), the frequency of nighttime dry cough decreased by about 70%; A follow-up chest HRCT scan after the fourth course of medication showed the following: The density of ground-glass nodules in both lungs has significantly decreased compared to before, and the largest diameter has shrunk to 4 mm; After taking the medication continuously for three and a half months, the nodules completely disappeared, and no recurrence was observed during an eight-month follow-up.

[0036] Case 2: COPD complicated by infectious pneumonia, coughing up purulent and hemoptytic sputum Mr. Zhao, male, 68 years old, was diagnosed with COPD 8 years ago. He had an acute exacerbation due to exposure to cold, and experienced chest tightness, shortness of breath, and coughing up yellow-green purulent sputum with occasional blood streaks. He was treated with this preparation. Therapeutic effect observation: On the second day of medication, the patient reported that the viscosity of the sputum decreased and it was easier to cough up; On the 5th day, the phlegm turned white and the blood streaks disappeared; By the end of the 7th day of treatment, the symptoms of shortness of breath and wheezing had significantly improved, the moist rales in both lungs had basically disappeared upon auscultation, and the pulmonary function test showed that the FEV1 / FVC ratio had increased from 52% before treatment to 64%.

[0037] In this embodiment, the adverse reactions and precautions are specifically described. This product is a pure herbal medicine and food preparation with high safety. However, a very small number of people with sensitive constitutions may experience mild reactions such as nausea, abdominal discomfort, dry mouth, and drowsiness, which will subside on their own after discontinuing the medication.

[0038] Contraindications and precautions: This medication is contraindicated for pregnant women and those allergic to any of its ingredients; avoid smoking, alcohol, and spicy, cold, or greasy foods while taking this medication; it should not be taken concurrently with tonifying Chinese herbal medicines. Patients with hypertension, heart disease, kidney disease, as well as breastfeeding women and children should use with caution. If fever exceeds 38.5℃ or shortness of breath worsens while taking the medication, seek medical attention immediately. This product should not be taken for a long period or in excessive amounts. It should not be used if its properties change. Children must use this product under adult supervision and keep it out of children's reach. Do not take with other medications to avoid interactions. The packaging label states "shake well before use".

[0039] The above description is merely a specific embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any person skilled in the art can easily conceive of various variations or substitutions within the technical scope disclosed in the present invention, and these should all be included within the scope of protection of the present invention. Therefore, the scope of protection of the present invention should be determined by the scope of the claims.

Claims

1. A herbal remedy for clearing the lungs and relieving cough, characterized in that, Based on the total weight percentage of the dried plant raw materials used to prepare the herbal granulation agent, it consists of the following main components: Cat's Claw Grass 8-10%, Gnaphalium affine 8-10%, Citrus reticulata peel 8-10%, Toad Grass 7-10%, Trichosanthes kirilowii 7-10%, Houttuynia cordata 7-9%, Polygonum aviculare 7-9%, Sargassum fusiforme 7-9%, Adenophora stricta 6-8%, Fritillaria cirrhosa 6-8%, and Perilla frutescens 5-7%; The auxiliary materials include 1-2% steviol glycosides and 1-2% pineapple flavoring, based on a percentage of the total weight of the dried plant raw materials. In addition, purified water is added as an extraction solvent and final formulation carrier, and the mixture is extracted and concentrated to produce an oral liquid formulation.

2. The herbal remedy for clearing the lungs and relieving cough according to claim 1, characterized in that, Based on the total weight percentage of the dried plant raw materials, the preferred ratio of the main ingredients is as follows: Cat's Claw Grass 9%, Gnaphalium affine 9%, Citrus reticulata peel 9%, Toad Grass 8.5%, Trichosanthes kirilowii 8.5%, Houttuynia cordata 8%, Polygonum multiflorum 8%, Coral Root 8%, Adenophora stricta 7%, Fritillaria cirrhosa 7%, and Perilla frutescens 6%; The amount of steviol glycosides added is 1.5% of the total weight of the dried raw materials, and the amount of pineapple flavor added is 1.5% of the total weight of the dried raw materials.

3. The herbal remedy for clearing the lungs and relieving cough according to claim 1, characterized in that, The finished product of the herbal granulation agent is a clear, brownish-brown liquid with a sweet and slightly bitter taste, and contains no added chemical preservatives.

4. A method for preparing a lung-clearing and cough-relieving herbal remedy as described in any one of claims 1-3, characterized in that, The following detailed steps are included: S1. Take the following dried plant products in the prescribed amounts: cat's claw grass, cudweed, tangerine peel, toad grass, trichosanthes, houttuynia cordata, angelica sinensis, coral grass, glehnia littoralis, fritillaria cirrhosa, and perilla seeds. Grind them into coarse powder. Use percolation method with 57% ethanol as solvent. After soaking for 24 hours, slowly percolate at a rate of 1 ml per minute and collect about 6000 ml of percolate. S2. The collected filtrate is depressurized to recover ethanol and concentrated to a volume of about 1400 ml. The concentrate is then removed and 800 ml of purified water is added. The mixture is boiled for 30 minutes and allowed to stand for 48 hours to allow impurities to precipitate. The filtrate and residue are filtered. The residue is washed with a small amount of purified water to obtain the washing liquid. The washing liquid is then added to the combined filtrate. S3. Concentrate the combined filtrate under reduced pressure to about 1000 ml, add the formula amount of steviol glycosides and pineapple flavoring, stir well, let stand for 24 hours, filter, add purified water to adjust to the final total volume and stir well to obtain the prepared medicine solution. S4. Heat the prepared medicine solution to a slight boiling point, quickly fill it into a clean, sterilized resin thermos bottle preheated to 80°C, immediately seal the bottle opening, and after cooling, a semi-vacuum state will be formed in the upper space of the bottle opening, thus obtaining the medicine.

5. The preparation method of the lung-clearing and cough-relieving herbal remedy according to claim 4, characterized in that, S4 utilizes a semi-vacuum physical environment created by hot filling and cooling to replace chemical preservatives, ensuring that the finished product does not ferment, mold, or spoil under sealed and cool conditions for one year.

6. The application of a lung-clearing and cough-relieving herbal remedy as described in any one of claims 1-3 in the preparation of a drug with the functions of clearing the lungs and resolving phlegm, relieving cough and eliminating phlegm, and repairing damaged alveoli.

7. The application according to claim 6, characterized in that, The drug is used to treat symptoms of coughing up purulent and hemoptysis caused by pulmonary ground-glass nodules, solid nodules, multiple nodules, infectious nodules, COPD, cor pulmonale, chronic bronchitis, and lung abscess.

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