Traditional Chinese medicine composition for preventing, alleviating or treating alzheimer's disease and pharmaceutical use thereof
By combining traditional Chinese medicines such as Cistanche deserticola in a "principal, assistant, adjuvant, and guide" configuration, the problems of excessive warming, excessive blood-activating, and excessive tonifying herbs in existing traditional Chinese medicine formulas for Alzheimer's disease have been solved. This has achieved effective prevention and treatment of Alzheimer's disease and improved cognitive function and neuronal state in mouse models.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- TIANSHENG PHARMA GROUP
- Filing Date
- 2026-04-15
- Publication Date
- 2026-06-09
AI Technical Summary
Existing traditional Chinese medicine formulas for Alzheimer's disease have problems such as excessive warming and tonifying, excessive blood-activating and tonifying, and imbalance of warming and cooling, resulting in significant side effects, limited efficacy, and inability to effectively improve the symptoms of Alzheimer's patients.
A combination of traditional Chinese medicines, including Cistanche deserticola, Polygonatum sibiricum, ginseng, Astragalus membranaceus, Angelica sinensis, Ligustrum lucidum, Salvia miltiorrhiza, and Panax notoginseng, is formulated according to the principle of "principal, assistant, adjuvant, and guide" in combination with the pathological characteristics of Alzheimer's disease. The resulting formulation is prepared in the form of extracts or granules for the prevention and treatment of Alzheimer's disease.
It significantly improves the novel object recognition index, spatial cognition ability and neuronal function in Alzheimer's disease mouse models, alleviates or prevents Alzheimer's disease-related symptoms, has few side effects, and is suitable for Alzheimer's disease in various individuals and with various symptoms.
Smart Images
Figure CN122163720A_ABST
Abstract
Claims
1. A traditional Chinese medicine composition for the prevention, relief or treatment of Alzheimer's disease, comprising 8-12 parts of Cistanche deserticola, 8-12 parts of Polygonatum sibiricum, 8-12 parts of ginseng, 12-18 parts of Astragalus membranaceus, 12-18 parts of Angelica sinensis, 12-18 parts of Ligustrum lucidum, 8-12 parts of Salvia miltiorrhiza, and 8-10 parts of Panax notoginseng, all by weight.
2. The traditional Chinese medicine composition according to claim 1, comprising 10 parts of Cistanche deserticola, 10 parts of Polygonatum sibiricum, 10 parts of ginseng, 15 parts of Astragalus membranaceus, 15 parts of Angelica sinensis, 15 parts of Ligustrum lucidum, 10 parts of Salvia miltiorrhiza, and 9 parts of Panax notoginseng, all by weight.
3. The traditional Chinese medicine composition according to claim 1 or 2, further comprising 12-18 parts of Acorus tatarinowii, 8-12 parts of Polygala tenuifolia, 1-2 parts of Styrax tinctoria, 8-12 parts of Alpinia oxyphylla, 8-12 parts of Poria cocos, 10-15 parts of Citrus medica, 8-10 parts of Perilla frutescens, 8-12 parts of Paeonia suffruticosa, 8-10 parts of Paeonia lactiflora, 12-18 parts of Ginkgo biloba, 4-6 parts of Leonurus japonicus, and 8-12 parts of Polygonatum odoratum, all by weight.
4. The traditional Chinese medicine composition according to claim 3, comprising 15 parts of Acorus tatarinowii, 10 parts of Polygala tenuifolia, 1 part of Styrax benzoin, 15 parts of Alpinia oxyphylla, 10 parts of Poria cocos, 12 parts of Citronella foenum-graecum, 9 parts of Perilla frutescens, 10 parts of Paeonia suffruticosa, 9 parts of Paeonia lactiflora, 15 parts of Ginkgo biloba, 5 parts of Leonurus japonicus, and 10 parts of Polygonatum odoratum, all in parts by weight.
5. A traditional Chinese medicine preparation for the prevention, relief or treatment of Alzheimer's disease, wherein the active ingredient is the traditional Chinese medicine composition as described in any one of claims 1-4.
6. The traditional Chinese medicine preparation according to claim 5, wherein the preparation is an extract, granule, decoction, pill, powder, oral solution, capsule, tablet, syrup, compound preparation or tea prepared by conventional methods.
7. The traditional Chinese medicine preparation according to claim 6, wherein the preparation is a granule obtained from an extract.
8. The method for preparing the traditional Chinese medicine preparation according to claim 7 includes mixing the weight parts of the medicine other than styrax with water to make an extract, grinding styrax into powder, mixing them, and then adding excipients to make granules.
9. Use of the traditional Chinese medicine composition according to any one of claims 1-4 or the traditional Chinese medicine preparation according to any one of claims 5-7 in the preparation of a medicament for the prevention, mitigation or treatment of Alzheimer's disease.