A circulating solid-phase reaction column system based on inductive heating and a method for performing a reaction

Abstract

The present application relates to a kind of cyclic solid-phase reaction column systems based on induction heating and its operating method.The system includes reaction column, liquid inlet pipeline, liquid outlet pipeline, circulation pipeline and diaphragm pump or plunger pump or plunger pump and valve arranged in each pipeline, reaction column is filled with solid beads or particles inside, copper induction coil is arranged on its outside, and is electrically connected with induction heating module.Circulation diaphragm pump or plunger pump or plunger pump is started under the condition that liquid inlet valve and liquid outlet valve are closed, to make aqueous solution form closed circulation in reaction column, utilize induction heating module to heat reaction column, realize the uniform circulation and heating of solution in reaction column.It can complete cleaning, reaction and product collection operation in the same reaction column, diaphragm pump or plunger pump can form fluid block in stop working state, with the function of pump and valve.The present application is simple in structure, high in heating efficiency, flexible in operation, and suitable for various solid-phase and aqueous reaction process.

Description

Technical Field

[0001] This invention relates to a chemical reaction apparatus in the field of chemistry, and more particularly to a circulating solid-phase reaction column system based on induction heating and its operation method. Background Technology

[0002] Currently, solid-phase reaction columns have wide applications in chemical synthesis, biochemical engineering, and materials preparation. Existing solid-phase reaction systems typically employ mechanical stirring, external heating jackets, or continuous flow reactor structures, which have the following shortcomings: 1. Mechanical stirring has a complex structure, which is prone to wear and introduces contamination; 2. External heating methods suffer from uneven heating and low thermal efficiency; 3. In multi-step or repeated reaction processes, cleaning of the reaction column, reaction and product collection often require frequent switching of pipelines or disassembly of equipment, which is cumbersome. 4. The existing system is highly dependent on valves and control components, resulting in high system complexity and failure rate.

[0003] In view of the shortcomings of the existing technology, there is an urgent need for a reaction system that is simple in structure, heats uniformly, operates flexibly, and can complete cleaning, reaction and product collection in the same reaction column. After continuous research, design and repeated trial production and improvement, the inventors have finally created this invention with practical value. Summary of the Invention

[0004] The purpose of this invention is to overcome the shortcomings of existing technologies and provide a novel circulating solid-phase reaction column system based on induction heating and its operation method. The technical problem to be solved is to enable it to form a closed loop under closed inlet and outlet conditions, thereby achieving the following objectives: 1. Uniform circulation of the aqueous phase solution within the reaction column; 2. Induction heating cyclic chemical reaction under induction heating conditions; 3. Achieve multiple cycles of cleaning, multiple cycles of induction heating chemical reactions, and multiple product collections within the same reaction column; 4. By utilizing diaphragm pumps or plunger pumps, which combine the functions of pumps and valves, the structure is simplified, the operation is easy, and the cost is reduced.

[0005] Compared with the prior art, the present invention has at least the following beneficial effects: 1. This invention achieves rapid and uniform heating of the reaction column through induction heating of the heating film block using a copper induction coil; 2. This invention does not require mechanical stirring. It achieves multiple induction heating cyclic chemical reactions within the reaction column using only a diaphragm pump or plunger pump and a copper induction coil induction heating module. This allows the molecules on the surface of the solid microspheres to fully contact the active molecules in the aqueous solution, further promoting a more complete induction heating cyclic chemical reaction and resulting in high-quality products.

[0006] 3. This invention uses a diaphragm pump or plunger pump that combines the functions of a pump and a valve, reducing the number of valves in the system, simplifying the structure, reducing pollution risks, and making it more environmentally friendly.

[0007] The objective of this invention and the technical problem it solves are achieved by the following technical solutions.

[0008] According to the present invention, a circulating solid-phase reaction column system based on induction heating is characterized by comprising: an inlet pipeline, an outlet pipeline, a first circulation pipeline, a second circulation pipeline, a copper induction coil, a reaction column, an induction heating module, an inlet diaphragm pump or a plunger pump, a circulation diaphragm pump or a plunger pump, and an outlet diaphragm pump or a plunger pump, and further comprising an inlet valve and an outlet valve, wherein: A copper induction coil is wound around the outside of the reaction column; the inside of the reaction column is filled with solid beads or particles; the upper part of the reaction column has a reaction column inlet, and the lower part of the reaction column has a reaction column outlet; the copper induction coil is electrically connected to the induction heating module. One end of the inlet pipeline is connected to the storage tank, and the other end of the inlet pipeline is connected in sequence to the inlet valve and one end of the inlet diaphragm pump or plunger pump. The other end of the inlet diaphragm pump or plunger pump is connected to the inlet of the reaction column through the second circulation pipeline. One end of the liquid outlet line is connected to the outlet of the reaction column, and the other end of the liquid outlet line is connected in sequence to the liquid outlet diaphragm pump or plunger pump and the liquid outlet valve. The outlet of the reaction column is connected to one end of the first circulation pipeline, the other end of the first circulation pipeline is connected to one end of the circulation diaphragm pump or plunger pump, and the other end of the circulation diaphragm pump or plunger pump is connected to the second circulation pipeline; one end of the second circulation pipeline is connected to the inlet of the reaction column. With the inlet and outlet valves closed, the system is driven and reversed by a circulating diaphragm pump or plunger pump. The aqueous solution in the column forms a closed loop, and an induction heating cyclic chemical reaction takes place in the reaction column under the action of the induction heating module.

[0009] Furthermore, a filter structure is provided at the outlet of the reaction column to prevent the solid beads or particles from flowing out with the liquid.

[0010] Furthermore, the filtration structure is a sand core filter plate.

[0011] Furthermore, it also includes a feeder for adding reaction materials into the reaction column, the feeder being connected to the inlet of the reaction column.

[0012] Furthermore, the inlet pipeline, the second circulation pipeline, the first circulation pipeline, and the outlet pipeline are made of polytetrafluoroethylene (PTFE) pipes.

[0013] Furthermore, the induction heating module is a zero-voltage switch (ZVS) induction heating module.

[0014] Furthermore, it also includes adding an aqueous solution into the reaction column. The aqueous solution must be conductive, specifically an aqueous solution containing metal ions or salt ions as a chemical reaction medium, so that the high-frequency current passing through the induction coil can generate a heating effect on the reaction column.

[0015] Furthermore, the inlet diaphragm pump or plunger pump, the circulation diaphragm pump or plunger pump, and the outlet diaphragm pump or plunger pump can all form a fluid blockage when they are not in operation, thereby serving as a valve shut-off function.

[0016] The objectives of this invention and the technical problems it addresses are further achieved through the following technical measures.

[0017] A method for carrying out a reaction based on an induction-heated circulating solid-phase reaction column system according to the present invention is characterized by comprising the following steps: Step 1: Packing: Pre-fill the reaction column with solid beads or particles; Step 2: Reaction column cleaning: With the circulating diaphragm pump or plunger pump and the outlet diaphragm pump or plunger pump off, the inlet diaphragm pump or plunger pump pumps the aqueous solution in the storage tank into the reaction column through the inlet pipeline and the second circulation pipeline. After the reaction column is filled with aqueous solution, the circulating diaphragm pump or plunger pump is turned off, and the passage of the inlet pipeline is also closed. Start the inlet diaphragm pump or plunger pump. The aqueous solution is pumped into the inlet line through the inlet valve and the second circulation line before entering the reaction column inlet, allowing the aqueous solution to enter the reaction column. After the reaction column is filled with aqueous solution, the inlet diaphragm pump or plunger pump is then turned off, which also closes the inlet line. Start the circulating diaphragm pump or plunger pump to circulate the aqueous solution multiple times in the reaction column. After the reaction column has been cleaned multiple times, turn off the circulating diaphragm pump or plunger pump, open the outlet valve and start the outlet diaphragm pump or plunger pump to draw the aqueous solution that has been cleaned multiple times out of the outlet of the reaction column and discharge it through the outlet pipeline and outlet valve. The direction of the circulating flow of the aqueous solution each time is the same as in step 3.4. Step 3: Induction heating cyclic chemical reaction Step 3.1: Add aqueous solution: With the circulating diaphragm pump or plunger pump and the outlet diaphragm pump or plunger pump closed, the inlet diaphragm pump or plunger pump pumps the aqueous solution in the storage tank into the reaction column through the inlet pipeline and the second circulation pipeline. After the reaction column is filled with aqueous solution, the circulating diaphragm pump or plunger pump is turned on, and the passage of the inlet pipeline is closed at the same time. Step 3.2: While the circulating diaphragm pump or plunger pump is running, start the heating module induced by the copper induction coil to microwave heat the reaction column; Step 3.3: Adding reactants: With the inlet diaphragm pump or plunger pump and the outlet diaphragm pump or plunger pump off, start the circulating diaphragm pump or plunger pump. At the start of each induction heating circulating chemical reaction, slowly add the required reactants into the reaction column and maintain this for the predetermined reaction time. The reactants are added to the reaction column through the feeder. Step 3.4: Perform multiple induction heating cyclic chemical reactions: The activated circulating diaphragm pump or plunger pump draws the aqueous solution from the reaction column outlet at the bottom of the reaction column, and then sequentially transports it to the reaction column inlet through the first and second circulating inlet lines. The aqueous solution undergoes induction heating cyclic chemical reactions as it flows from the top to the bottom of the reaction column. Afterward, the aqueous solution is drawn out from the reaction column outlet through the circulating diaphragm pump or plunger pump. Thus, the aqueous solution is repeatedly transported to the reaction column through the first and second circulating inlet lines to undergo multiple induction heating cyclic chemical reactions, ensuring that the molecules on the surface of the solid microspheres are in full contact with the active molecules in the aqueous solution, further promoting the induction heating cyclic chemical reactions. Step 4: Waste liquid removal: After the multiple induction heating cycle chemical reactions are completed, stop the circulating diaphragm pump or plunger pump and the induction heating module, and at the same time start the liquid discharge diaphragm pump or plunger pump to extract the various waste liquids in the reaction column through the reaction column outlet, and discharge them through the liquid discharge pipeline, liquid discharge diaphragm pump or plunger pump and hydraulic valve. After completing steps 1-4, repeat steps 2, 3, and 4, doing this multiple times, but with different reactants added each time. Step 5: Product Collection Step: After all induction heating cyclic chemical reactions are completed, add a pyrolysis reagent or extraction solution into the reaction column to break the bonds between the synthetic molecular products generated on the surface of the solid beads or particles during multiple induction heating cyclic chemical reactions and the surface of the solid beads or particles. This releases the synthetic molecular products from the surface of the solid beads or particles and dissolves them in the aqueous solution. At this time, stop the circulating diaphragm pump or plunger pump and the induction heating module, and simultaneously start the outlet diaphragm pump or plunger pump to extract the aqueous solution containing the synthetic molecular products in the reaction column through the outlet of the reaction column. The solution is discharged and collected through the outlet pipeline, outlet diaphragm pump or plunger pump and outlet hydraulic valve. Step 5 of product collection is repeated at least twice.

[0018] Furthermore, the reaction raw materials are various amino acids or other chemical molecular groups, such as 20 different amino acids, or nucleotides, or monosaccharides.

[0019] Furthermore, the solid beads or particles are solid-phase chemical reaction carriers, and the solid beads or particles are ion exchange resins, agarose microspheres, or cellulose.

[0020] Furthermore, the solid-phase chemical reaction carrier is used for solid-phase peptide synthesis or other solid-phase chemical reactions. The solid-phase chemical reaction carrier uses molecular groups on the surface of solid beads or particles as the reaction starting point, and uses multiple amino acids or other chemical molecular groups as reaction groups. Each induction heating cycle chemical reaction adds one amino acid or other chemical molecular group as a reaction group, and multiple induction heating cycle chemical reactions are carried out.

[0021] The above description is merely an overview of the technical solution of the present invention. In order to better understand the technical means of the present invention and to implement it in accordance with the contents of the specification, and to make the above and other objects, features and advantages of the present invention more apparent and understandable, preferred embodiments are described below in detail with reference to the accompanying drawings. Attached Figure Description

[0022] Figure 1 This is a schematic diagram of the combined structure of the present invention.

[0023] Explanation of icon numbers in: 1: Raw material feeder 2: Liquid inlet line 3: Second circulation pipeline; 4: Reaction column inlet 5: Copper induction coil; 6: Reaction column 7: Sand core filter plate; 8: Induction heating module 9: Discharge line 10: Inlet diaphragm pump or plunger pump 11: Inlet valve; 12: Circulating diaphragm pump or plunger pump 13: Discharge diaphragm pump or plunger pump 14: Reaction column outlet 15: Discharge valve 16: Storage tank 17: First circulation pipeline Detailed Implementation

[0024] To further illustrate the technical means and effects adopted by the present invention to achieve the intended purpose, the following, in conjunction with the accompanying drawings and preferred embodiments, details the specific implementation, structure, method (manufacturing method, processing method), steps, features and effects of a circulating solid-phase reaction column system based on induction heating and its operation method proposed according to the present invention.

[0025] Please see Figure 1 As shown, a preferred embodiment of the present invention is a circulating solid-state heating system based on induction heating. The reaction column system mainly includes: a reaction column 6 filled with solid beads or particles. The reaction column 6 includes a copper induction coil 5 wound around its exterior, an induction heating module 8 electrically connected to the copper induction coil 5, an inlet diaphragm pump or plunger pump 10 and an inlet pipeline 2, a circulation diaphragm pump or plunger pump 12 and a first circulation pipeline 17 and a second circulation pipeline 3, an outlet diaphragm pump or plunger pump 13 and an outlet pipeline 9, a filter structure 7, and a raw material feeder 1. It also includes an inlet valve 11 and an outlet valve 15. Wherein: A copper induction coil 5 is wound around the reaction column 6; the upper part of the reaction column 6 is provided with a reaction column inlet 4, and the lower part of the reaction column 6 is provided with a reaction column outlet 14; One end of the liquid inlet pipeline 2 is connected to the liquid storage tank 16, and the other end of the liquid inlet pipeline 2 is connected in sequence to the inlet valve 11 and one end of the liquid inlet diaphragm pump or plunger pump 10. The other end of the liquid inlet diaphragm pump or plunger pump 10 is connected to the reaction column inlet 4 through the second circulation pipeline 3. One end of the liquid outlet line 9 is connected to the outlet 14 of the reaction column, and the other end of the liquid outlet line 9 is connected in sequence to the liquid outlet diaphragm pump or plunger pump 13 and the liquid outlet valve 15. The reaction column outlet 14 is connected to one end of the first circulation line 17, the other end of the first circulation line 17 is connected to one end of the circulation diaphragm pump or plunger pump 12, and the other end of the circulation diaphragm pump or plunger pump 12 is connected to the second circulation line 3; one end of the second circulation line 3 is connected to the reaction column inlet 4. With inlet valve 11 and outlet valve 15 closed, the pump is driven by a circulating diaphragm pump or plunger pump. The aqueous solution in the reaction column 6 and the moving 12 form a closed loop, and an induction heating cyclic chemical reaction is carried out in the reaction column 6 under the action of the induction heating module 8.

[0026] The filter structure 7 is located at the outlet 14 of the reaction column to prevent the solid beads or particles from flowing out with the liquid. This filter structure 7 is a sand core filter plate. The raw material feeder 1 is connected to the inlet 4 of the reaction column and is used to add the reaction raw materials into the reaction column 6.

[0027] The inlet pipeline 2, outlet pipeline 9, second circulation pipeline 3, and first circulation pipeline 17 are all made of polytetrafluoroethylene (PTFE) pipes. The induction heating module 8 is a zero-voltage switch (ZVS) induction heating module.

[0028] The aqueous solution added to the reaction column 6 must be conductive, specifically an aqueous solution containing metal ions or salt ions as a chemical reaction medium, so that the high-frequency current passing through the induction coil 5 can generate a heating effect on the reaction column 6.

[0029] The inlet diaphragm pump or plunger pump 10, the circulation diaphragm pump or plunger pump 12, and the outlet diaphragm pump or plunger pump 13 can all form a fluid blockage when they are not in operation, thereby serving as a valve shut-off function.

[0030] A preferred embodiment of the present invention provides a method for carrying out a reaction using a circulating solid-phase reaction column system based on induction heating, which mainly includes the following steps: Step 1: Packing material: Pre-fill the reaction column 6 with solid beads or particles; Step 2: Cleaning of reaction column 6: With the circulating diaphragm pump or plunger pump 12 and the outlet diaphragm pump or plunger pump 13 closed, the inlet diaphragm pump or plunger pump 10 pumps the aqueous solution in the storage tank 16 into the reaction column 6 through the inlet line 2 and the second circulation line 3. After the reaction column 6 is filled with aqueous solution, the circulating diaphragm pump or plunger pump 12 is closed, and the passage of the inlet line 2 is also closed. The aqueous solution is pumped into the inlet line 2 through the inlet diaphragm pump or plunger pump 10, and then sequentially enters the reaction column inlet 4 through the inlet valve 11 and the second circulation line 3, so that the aqueous solution enters the reaction column 6. After the reaction column 6 is filled with aqueous solution, the inlet diaphragm pump or plunger pump 10 is then turned off, and the passage of the inlet line 2 is also closed. Start the circulating diaphragm pump or plunger pump 12 to circulate and clean the aqueous solution multiple times in the reaction column 6. After the reaction column 6 has been cleaned multiple times, turn off the circulating diaphragm pump or plunger pump 12, open the outlet valve 15 and start the outlet diaphragm pump or plunger pump 13 to draw the aqueous solution that has been cleaned multiple times out of the reaction column outlet 14 and discharge it through the outlet pipeline 9 and outlet valve 15; the direction of the aqueous solution circulation flow is the same as in step 3.4 each time. Step 3: Induction heating cyclic chemical reaction Step 3.1: Add aqueous solution: With the circulating diaphragm pump or plunger pump 12 and the outlet diaphragm pump or plunger pump 13 closed, the inlet diaphragm pump or plunger pump 10 pumps the aqueous solution in the storage tank 16 into the reaction column 6 through the inlet line 2 and the second circulation line 3. After the reaction column 6 is filled with aqueous solution, the circulating diaphragm pump or plunger pump 12 is turned on, and the passage of the inlet line 2 is closed at the same time. Step 3.2: While the circulating diaphragm pump or plunger pump 12 is running, start the heating module 8 induced by the copper induction coil 5 to microwave heat the reaction column 6; Step 3.3: Adding reaction materials: With the inlet diaphragm pump or plunger pump 10 and the outlet diaphragm pump or plunger pump 13 off, start the circulation diaphragm pump or plunger pump 12. At the start of each induction heating cyclic chemical reaction, slowly add the required reaction materials into the reaction column 6 and maintain this until the predetermined reaction time; the reaction materials are added to the reaction column 6 through the material feeder 1. Step 3.4: Perform multiple induction heating cyclic chemical reactions: The activated circulating diaphragm pump or plunger pump 12 draws the aqueous solution from the reaction column outlet 14 at the bottom of the reaction column 6, and then sequentially delivers it to the reaction column inlet 4 of the reaction column 6 through the first circulating inlet line 17 and the second circulating line 3. Then, as the aqueous solution flows from the top to the bottom of the reaction column 6, it undergoes an induction heating cyclic chemical reaction. Finally, the circulating diaphragm pump or plunger pump 12 draws the aqueous solution from the reaction column outlet 14 within the reaction column 6. Thus, the aqueous solution is repeatedly delivered to the reaction column 6 through the first circulating inlet line 17 and the second circulating line 3 for multiple induction heating cyclic chemical reactions, ensuring sufficient contact between the molecules on the surface of the solid microspheres and the active molecules in the aqueous solution, further promoting the induction heating cyclic chemical reaction. Step 4: Waste liquid removal: After the multiple induction heating cycle chemical reactions are completed, stop the circulating diaphragm pump or plunger pump 12 and the induction heating module 8, and at the same time start the liquid discharge diaphragm pump or plunger pump 13 to extract the various waste liquids in the reaction column 6 through the reaction column outlet 14, and discharge them through the liquid discharge pipeline 9, the liquid discharge diaphragm pump or plunger pump 13 and the hydraulic valve 15. After completing steps 1-4 above, repeat steps 2, 3 and 4, and repeat the process multiple times, but each time different reaction raw materials are added.

[0031] Step 5: Product Collection Step: After all induction heating cyclic chemical reactions are completed, a pyrolysis reagent or extraction solution is added to the reaction column 6 to break the bonds between the synthetic molecular products generated on the surface of the solid beads or particles during multiple induction heating cyclic chemical reactions and the surface of the solid beads or particles. This releases the synthetic molecular products from the surface of the solid beads or particles and dissolves them in the aqueous solution. At this time, the circulating diaphragm pump or plunger pump 12 and the induction heating module 8 are stopped. At the same time, the liquid discharge diaphragm pump or plunger pump 13 is started to draw the aqueous solution containing the synthetic molecular products in the reaction column 6 through the reaction column outlet 14. The solution is then discharged and collected through the liquid discharge line 9, the liquid discharge diaphragm pump or plunger pump 13 and the liquid discharge valve 15. Step 5 of product collection is repeated at least twice.

[0032] The reaction raw materials used in this invention are various amino acids or other chemical molecular groups, such as 20 kinds of amino acids, or nucleotides, or monosaccharides. The solid beads or particles used are ion exchange resins, or agarose microspheres, or cellulose.

[0033] The solid beads or particles in this invention serve as solid-phase chemical reaction carriers. These carriers are used for solid-phase peptide synthesis or other solid-phase chemical reactions. The solid-phase chemical reaction carriers use the molecular groups on the surface of the solid beads or particles as the reaction initiation point and various amino acids or other chemical molecular groups as the reaction groups. Each induction heating cycle of chemical reaction adds one amino acid or another chemical molecular group as the reaction group, and multiple induction heating cycles of chemical reaction are carried out.

[0034] Specific embodiment: For example, a polypeptide containing 10 amino acids requires a reaction method based on an induction heating cyclic solid-phase reaction column system: it needs to perform step 1 once, step 2 multiple times, step 3.1 once, step 3.2 slowly adding the reaction raw materials ten times, and step 3.3 performing ten induction heating cyclic chemical reactions. In each induction heating cyclic chemical reaction, one amino acid is added. After the tenth induction heating cyclic chemical reaction is completed, a cleavage reagent or extraction solution is added to cause the molecule of the polypeptide containing 10 amino acids to cleave from the surface of the solid particles, enter the solution, and be discharged.

[0035] This invention is applicable to, but not limited to, solid-phase chemical synthesis (including peptides, oligonucleotides, etc.), adsorption and desorption reactions on solid supports, aqueous-phase catalytic reactions, and biomaterial processing.

[0036] The three diaphragm pumps or plunger pumps of this invention should not operate simultaneously. Their operating principle is as follows: 1. With the circulating diaphragm pump or plunger pump 12 and the outlet diaphragm pump or plunger pump 13 closed, the circulating diaphragm pump or plunger pump 12 is a water supply pump. The circulating diaphragm pump or plunger pump 12 pumps the aqueous solution in the storage tank 16 through the inlet pipeline 2 and the second circulation pipeline 3 to the reaction column 6. After the reaction column 6 is filled with aqueous solution, the circulating diaphragm pump or plunger pump 12 is closed, and the passage of the circulation pipeline 2 is also closed.

[0037] 2. With the inlet diaphragm pump or plunger pump 10 and the outlet diaphragm pump or plunger pump 13 closed, start the circulating outlet diaphragm pump or plunger pump 12. The outlet diaphragm pump or plunger pump 12 draws the aqueous solution from the bottom of the reaction column 6 through the reaction column outlet 14, and then sequentially through the first circulation line 17 and the second circulation line 3 to the reaction column inlet 4 of the reaction column 6. The flow direction of the aqueous solution is as follows: from the reaction column outlet 14 through the first circulation line 17 to the circulating diaphragm pump or plunger pump 12, then to the second circulation line 3, through the second circulation line 3 to the reaction column inlet 4, and then through the reaction column 6 to the reaction column outlet 14. This circulation circulates the water in the reaction column 6, which ensures that the molecules on the surface of the solid microspheres in the reaction column come into full contact with the active molecules in the water, promoting the chemical reaction.

[0038] 3. After the chemical reaction is completed, with the inlet diaphragm pump or plunger pump 10 and the circulation diaphragm pump or plunger pump 12 closed, start the outlet diaphragm pump or plunger pump 13. At the same time, add cleaning liquid or elution liquid to the raw material feeder 1. The reaction products on the surface of the solid microspheres will be eluted and drawn out by the outlet diaphragm pump or plunger pump 13.

[0039] Furthermore, the above examples include sequential exemplary steps, but these steps need not be performed in the order shown. Performing these steps in different orders is within the scope of this invention. Within the spirit and scope of the embodiments of this invention, these steps may be added, substituted, changed in order, and / or omitted as appropriate.

[0040] Although the present invention has been disclosed above with reference to embodiments, it is not intended to limit the scope of the invention. Any person skilled in the art can make various modifications and refinements without departing from the spirit and scope of the invention. Therefore, the scope of protection of the present invention shall be determined by the claims.

Claims

1. A circulating solid-phase reaction column system based on induction heating, characterized in that, include: The system includes an inlet pipeline (2), an outlet pipeline (9), a first circulation pipeline (17), a second circulation pipeline (3), a copper induction coil (5), a reaction column (6), an induction heating module (8), an inlet diaphragm pump or plunger pump (10), a circulation diaphragm pump or plunger pump (12), and an outlet diaphragm pump or plunger pump (13), and also includes an inlet valve (11) and an outlet valve (15), wherein: A copper induction coil (5) is placed on the outside of the reaction column (6) and wound around the reaction column (6); the inside of the reaction column (6) is filled with solid beads or particles; the upper part of the reaction column (6) is provided with a reaction column inlet (4) and the lower part of the reaction column (6) is provided with a reaction column outlet (14); the copper induction coil (5) is electrically connected to the induction heating module (8). One end of the liquid inlet pipeline (2) is connected to the liquid storage tank (16), and the other end of the liquid inlet pipeline (2) is connected to the liquid inlet valve (11) and the liquid inlet diaphragm pump or plunger pump (10) in sequence. The other end of the liquid inlet diaphragm pump or plunger pump (10) is connected to the reaction column inlet (4) through the second circulation pipeline (3). One end of the liquid outlet line (9) is connected to the outlet (14) of the reaction column, and the other end of the liquid outlet line (9) is connected to the liquid outlet diaphragm pump or plunger pump (13) and the liquid outlet valve (15) in sequence. The reaction column outlet (14) is connected to one end of the first circulation line (17), the other end of the first circulation line (17) is connected to one end of the circulation diaphragm pump or plunger pump (12), and the other end of the circulation diaphragm pump or plunger pump (12) is connected to the second circulation line (3); one end of the second circulation line (3) is connected to the reaction column inlet (4). With the inlet valve (11) and outlet valve (15) closed, the circulating diaphragm pump or plunger pump drives (12) to form a closed loop with the aqueous solution in the reaction column (6), and the induction heating circulating chemical reaction is carried out in the reaction column (6) under the action of the induction heating module (8).

2. The circulating solid-phase reaction column system based on induction heating according to claim 1, characterized in that, A filter structure (7) is provided at the outlet of the reaction column (6) to prevent the solid beads or particles from flowing out with the liquid.

3. The circulating solid-phase reaction column system based on induction heating according to claim 2, characterized in that: The filter structure (7) is a sand core filter plate.

4. The circulating solid-phase reaction column system based on induction heating according to claim 1, characterized in that, It also includes a feeder (1) for adding reaction raw materials to the reaction column (6), and the feeder (1) is connected to the inlet (4) of the reaction column.

5. A circulating solid-phase reaction column system based on induction heating according to claim 1, characterized in that, The inlet pipeline (2), the second circulation pipeline (3), the first circulation pipeline (17), and the outlet pipeline (9) are made of polytetrafluoroethylene pipes.

6. A circulating solid-phase reaction column system based on induction heating according to claim 1, characterized in that, The induction heating module (8) is a zero-voltage switch (ZVS) induction heating module.

7. A circulating solid-phase reaction column system based on induction heating according to claim 1, characterized in that, It also includes an aqueous solution added to the reaction column (6). The aqueous solution must be conductive. Specifically, it is an aqueous solution containing metal ions or salt ions as a chemical reaction medium so that the high-frequency current passing through the induction coil (5) can generate a heating effect on the reaction column (6).

8. A circulating solid-phase reaction column system based on induction heating according to claim 1, characterized in that, The inlet diaphragm pump or plunger pump (10), the circulation diaphragm pump or plunger pump (12), and the outlet diaphragm pump or plunger pump (13) can all form a fluid blockage when they are not in operation, thereby serving as a valve shut-off function.

9. A method for carrying out a reaction using a circulating solid-phase reaction column system based on induction heating as described in any one of claims 1-8, characterized in that, Includes the following steps: Step 1: Filler: Pre-fill the reaction column (6) with solid beads or particles; Step 2: Cleaning of the reaction column (6): With the circulating diaphragm pump or plunger pump (12) and the outlet diaphragm pump or plunger pump (13) closed, the inlet diaphragm pump or plunger pump (10) pumps the aqueous solution in the storage tank (16) into the reaction column 6 through the inlet pipeline (2) and the second circulation pipeline (3). After the reaction column (6) is filled with aqueous solution, the circulating diaphragm pump or plunger pump (12) is closed, and the passage of the inlet pipeline (2) is also closed. Start the inlet diaphragm pump or plunger pump (10). Pump the aqueous solution into the inlet line (2) through the inlet valve (11) and the second circulation line (3) in sequence, and then into the reaction column inlet (4) so ​​that the aqueous solution enters the reaction column (6). After the reaction column (6) is filled with aqueous solution, turn off the inlet diaphragm pump or plunger pump (10), and at the same time close the passage of the inlet line (2). Start the circulating diaphragm pump or plunger pump (12) to circulate the aqueous solution multiple times in the reaction column (6). After the reaction column (6) has been cleaned multiple times, turn off the circulating diaphragm pump or plunger pump (12), open the outlet valve (15) and start the outlet diaphragm pump or plunger pump (13) to draw the aqueous solution after multiple cleanings out of the outlet (14) of the reaction column and discharge it through the outlet pipeline (9) and outlet valve (15); the direction of the circulating flow of the aqueous solution each time is the same as in step 3.

4. Step 3: Induction heating cyclic chemical reaction Step 3.1: Add aqueous solution: With the circulating diaphragm pump or plunger pump (12) and the outlet diaphragm pump or plunger pump (13) closed, the inlet diaphragm pump or plunger pump (10) pumps the aqueous solution in the storage tank (16) into the reaction column (6) through the inlet pipeline (2) and the second circulation pipeline (3). After the reaction column (6) is filled with aqueous solution, the circulating diaphragm pump or plunger pump (12) is turned on, and the passage of the inlet pipeline (2) is closed at the same time. Step 3.2: While the circulating diaphragm pump or plunger pump (12) is running, start the heating module (8) induced by the copper induction coil (5) to microwave heat the reaction column (6); Step 3.3: Adding reaction raw materials: With the inlet diaphragm pump or plunger pump (10) and outlet diaphragm pump or plunger pump (13) closed, start the circulation diaphragm pump or plunger pump (12). At the start of each induction heating cyclic chemical reaction, slowly add the required reaction raw materials into the reaction column (6) and maintain this until the predetermined reaction time. The reaction raw materials are added to the reaction column (6) through the raw material feeder (1). Step 3.4: Perform multiple induction heating cyclic chemical reactions: The activated circulating diaphragm pump or plunger pump (12) draws the aqueous solution from the reaction column outlet (14) at the bottom of the reaction column (6), and then sequentially transports it to the reaction column inlet (4) of the reaction column (6) through the first circulating inlet line (17) and the second circulating line (3). After the aqueous solution flows from the upper part to the lower part of the reaction column (6) to perform an induction heating cyclic chemical reaction, the aqueous solution in the reaction column (6) is drawn out from the reaction column outlet (14) through the circulating diaphragm pump or plunger pump (12). Thus, the aqueous solution is repeatedly transported to the reaction column (6) through the first circulating inlet line (17) and the second circulating line (3) to perform multiple induction heating cyclic chemical reactions, so that the molecules on the surface of the solid microspheres are in full contact with the active molecules in the aqueous solution, which further promotes the induction heating cyclic chemical reaction. Step 4: Waste liquid removal: After the multiple induction heating cycle chemical reactions are completed, stop the circulating diaphragm pump or plunger pump (12) and the induction heating module (8), and at the same time start the liquid discharge diaphragm pump or plunger pump (13) to extract the various waste liquids in the reaction column (6) through the reaction column outlet (14), and discharge them through the liquid discharge pipeline (9), the liquid discharge diaphragm pump or plunger pump (13) and the hydraulic valve (15); After completing steps 1-4, repeat steps 2, 3, and 4, doing this multiple times, but with different reactants added each time. Step 5: Product collection step: After all the induction heating cycle chemical reactions are completed, add the pyrolysis reagent or extraction solution into the reaction column (6) to break the linkage bond between the synthetic molecular product generated on the surface of the solid beads or particles during the multiple induction heating cycle chemical reactions and the surface of the solid beads or particles, thereby releasing the synthetic molecular product from the surface of the solid beads or particles and dissolving it in the aqueous solution. At this time, stop the circulation diaphragm pump or plunger pump (12) and the induction heating module (8), and start the liquid outlet diaphragm pump or plunger pump (13) to extract the aqueous solution containing the synthetic molecular product in the reaction column (6) through the reaction column outlet (14), and discharge and collect it through the liquid outlet pipeline (9), the liquid outlet diaphragm pump or plunger pump (13) and the liquid outlet valve (15). The product collection step 5 is repeated at least twice.

10. A method for carrying out a reaction using a circulating solid-phase reaction column system based on induction heating according to claim 9, characterized in that: The reaction raw materials are various amino acids or other chemical molecular groups, such as 20 different amino acids, or nucleotides, or monosaccharides.

11. A method for carrying out a reaction using a circulating solid-phase reaction column system based on induction heating according to claim 10, characterized in that: The solid beads or particles are solid-phase chemical reaction carriers, and the solid beads or particles are ion exchange resins, agarose microspheres, or cellulose.

12. A method for carrying out a reaction using a circulating solid-phase reaction column system based on induction heating according to claim 11, characterized in that: The solid-phase chemical reaction carrier is used for solid-phase peptide synthesis or other solid-phase chemical reactions. The solid-phase chemical reaction carrier uses the molecular groups on the surface of solid beads or particles as the reaction starting point, and uses a variety of amino acids or other chemical molecular groups as reaction groups. Each induction heating cycle chemical reaction adds one amino acid or another chemical molecular group as a reaction group, and multiple induction heating cycle chemical reactions are carried out.

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