A compound of pyrrolopyridine structure, preparation method and medical use

CN122167421APending Publication Date: 2026-06-09NANJING LINGNUO BIOMEDICAL TECH RES INST CO LTD
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Patent Information

Application Number
CN202411802362.2
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-12-09
Publication Date
2026-06-09

AI Technical Summary

Technical Problem

Existing JAK inhibitor drugs have limited efficacy in treating various diseases such as autoimmune diseases and myeloproliferative disorders, and there is a lack of highly effective JAK protein kinase inhibitors.

Method used

To develop a compound with a pyrrolopyridine structure and its synthetic method, and to treat related diseases by inhibiting JAK protein kinase.

Benefits of technology

This compound exhibits excellent JAK protein kinase inhibitory activity, and can effectively treat or alleviate a variety of immune diseases, myeloproliferative disorders, and inflammatory diseases of the central nervous system.

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Patent Text Reader

Abstract

This invention discloses a compound with a pyrrolopyridine structure, its preparation method, and its pharmaceutical uses. This invention provides a novel compound with a pyrrolopyridine structure and a method for synthesizing this series of compounds. Activity studies show that the compound with the pyrrolopyridine structure possesses excellent JAK protein kinase inhibitory activity. Those skilled in the art know that JAK protein kinase plays an important role in the occurrence and development of various diseases, such as various immune diseases, myeloproliferative disorders, and central nervous system inflammatory diseases; inhibiting JAK can treat or alleviate these diseases. Therefore, the compound with the pyrrolopyridine structure provided by this invention has the potential for development into a JAK inhibitor drug and for treating or alleviating diseases by inhibiting JAK.
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