Preparation method of 3-(pyridine-2-yl) imidazo [1, 5-a] pyridine
The method of preparing 3-(pyridin-2-yl)imidazo[1,5-a]pyridine under mild conditions via a one-step process using an inexpensive copper salt catalyst and di-tert-butyl peroxide solves the problems of excessive raw materials and harsh conditions in existing technologies, and achieves a highly efficient and clean preparation process.
Patent Information
- Application Number
- CN202610368214.7
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2026-03-24
- Publication Date
- 2026-06-09
AI Technical Summary
The existing methods for preparing 3-(pyridin-2-yl)imidazo[1,5-a]pyridine require two raw materials, have harsh reaction conditions, require large amounts of reagents, cause heavy pollution, have poor atom economy, and require a variety of additives.
3-(pyridin-2-yl)imidazo[1,5-a]pyridine was prepared by a one-step process under mild conditions using a cheap copper salt catalyst such as cuprous iodide to oxidize dimethylpyridinium amine with di-tert-butyl peroxide. The reaction temperature was 100 °C, the solvent was fluorobenzene, the amount of catalyst was 0.4 times that of dimethylpyridinium amine, and the amount of oxidant was 3.0 times that of dimethylpyridinium amine.
It achieves a simple, efficient, and clean preparation process, reduces the amount of additives used, simplifies the operation process, and is suitable for laboratory pilot tests and industrial exploration.